@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0032: (2017-12-14 )
MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVAEFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNMSSADVAEGLDFTIVDQISQDMLSEESIFHFELFGENYHTDNLVGFAWSCGDQLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIVVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDNVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340-.........350.--------......360.--..--....370.......380-.......390.......400...-.-...410...--....420.......430.......440.......450........460....-...470.......480.......490.......500.......510.......520.......530.......540.......550-........560.......570.......580.......590.....-..600........610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDK
K
K
L
L
L
IDGS
S
V
A
F
R
A
F
F
A
L
Y
Q
Q
L
D
R
F
K
N
AAGLHTN
A
I
Y
G
F
Q
L
M
L
S
H
L
L
E
RVEPS
H
I
L
V
A
FDAGK
T
T
F
R
T
E
M
Y
A
DYKGGRAK
T
P
D
E
F
R
E
Q
F
P
F
I
R
E
L
L
D
HMGIRH
Y
E
L
A
QY
E
A
D
D
I
I
G
T
L
D
K
L
A
EQDG
F
D
I
T
I
VSGD
K
D
L
I
Q
LTDE
H
T
V
V
E
I
S
KKGV
A
E
F
EAF
T
P
D
Y
L
M
E
E
MGL
T
P
A
Q
F
I
D
L
K
A
LMGDKSDNIPGVTKVGEKT
G
I
K
L
L
LEHGSL
E
G
I
Y
E
NIDGM
K
T
S
K
M
K
E
N
LIN
D
K
E
Q
A
F
L
S
K
T
L
A
TIDTKA
P
I
A
IG
L
E
D
LVYSGP
D
V
E
N
L
G
K
F
Y
D
E
M
G
F
K
Q
L
K
Q
A
LNMS
S
A
D
V
AEGLD
F
T
I
V
D
Q
I
S
Q
D
M
LSEE
S
I
F
H
F
E
L
FGENYHTD
N
L
V
G
F
A
WS---CGDQLYA
T
D
K
L
E
L
--------
L
Q
D
P
I
F
K
D
F
L
--
E
K--TS
L
R
V
Y
D
F
K
K
V
K
V
L
L
Q
R
-FGVDLQAP
A
F
D
I
R
L
A
K
Y
L
L
S
TVE-D-N
E
I
A
T
I
A
S
L--YG
Q
T
Y
L
VDDETFYGK
G
V
K
K
AI
P
E
R
E
K
F
L
E
H
L
A
C
K
L
A
-
V
L
VETE
P
I
L
L
E
K
LSE-NG
Q
L
E
L
L
YDMEQ
P
L
A
F
V
L
A
K
M
E
I
A
G
I
V
V
K
K
E
T
L
L
E
MQAE
N
E
L
V
I
E
K
L
T
Q
E
I
Y
E
LAGEEFNVN
S
P
K
Q
L
G
V
L
L
F
E
K
LGLP
L
E
Y
TKKT--KTGY
S
T
A
V
D
V
L
E
R
LA
P
I
A
P
I
V
K
K
I
L
D
Y
R
Q
I
A
K
IQ
S
T
Y
V
I
G
L
Q
D
WIL-ADGK-
I
H
T
R
Y
V
Q
D
L
T
QTGRLSSVDP
N
L
Q
N
I
P
A
R
L
E
Q
G
R
L
I
R
K
A
FVPEWED
S
V
L
LSSDYS
Q
I
E
L
R
V
L
A
H
ISK
D
E
H
L
I
K
A
F
Q
EGADIHTS
T
A
M
R
V
F
GIERPDNVTANDRRN
A
K
A
V
N
F
G
V
V
Y
G
I
SDFGLSNNLGI
S
R
K
E
A
K
A
Y
I
D
T
Y
F
E
RFP
G
I
K
N
Y
M
D
E
V
V
R
E
A
RDK
G
Y
V
E
T
L
F
K
R
R
RELPDINSR
N
F
N
I
R
G
F
AERTAINSPIQG
S
A
A
D
I
L
K
I
A
M
I
Q
L
D
K
A
L
VAGGY
Q
T
K
M
L
L
Q
VH
D
E
I
V
LEV
P
K
S
E
L
V
E
M
K
K
L
V
K
Q
T
M
E
E
A
I
Q
LSV
P
L
I
ADENEGATWYEAK
43
PsiBlast_CBE
86.82
50%
-14
- C3 -
-
1L5U
4
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
98
PsiBlast_CBE
86.63
50%
-13
- C3 -
-
3PV8
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
30
PsiBlast_CBE
86.42
50%
-14
- C3 -
-
1NKC
1
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
6
PsiBlast_PDB
86.41
50%
-16
- C3 -
-
1UA0
2
?
A:
[2-580]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
33
PsiBlast_CBE
86.30
50%
-15
- C3 -
-
1NK8
3
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
17
PsiBlast_PDB
86.22
50%
-14
- C3 -
-
2HHU
5
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
47
PsiBlast_CBE
86.20
50%
-13
- C3 -
-
1L3S
4
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
3
PsiBlast_PDB
86.17
50%
-14
- C3 -
-
1U48
1
DPO1_GEOSE
A:
[2-580]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
20
PsiBlast_PDB
86.15
50%
-16
- C3 -
-
2HW3
4
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
68
PsiBlast_CBE
86.12
50%
-16
- C3 -
-
2XY6
4
?
A:
[4-581]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
63
PsiBlast_CBE
86.11
50%
-17
- C3 -
-
4B9S
3
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
49
PsiBlast_CBE
86.11
50%
-16
- C3 -
-
4DSI
5
?
A:
[4-581]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
74
PsiBlast_CBE
86.09
50%
-14
- C3 -
-
4F4K
3
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
32
PsiBlast_CBE
86.01
50%
-15
- C3 -
-
1NK9
2
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
16
PsiBlast_PDB
86.01
50%
-12
- C3 -
-
2HHT
4
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
1
PsiBlast_PDB
86.00
50%
-13
- C3 -
-
1U45
1
DPO1_GEOSE
A:
[2-580]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
29
PsiBlast_CBE
85.99
50%
-14
- C3 -
-
1NKE
3
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
18
PsiBlast_PDB
85.98
50%
-14
- C3 -
-
2HHV
4
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
15
PsiBlast_PDB
85.95
50%
-15
- C3 -
-
2HHS
4
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
76
PsiBlast_CBE
85.86
50%
-13
- C3 -
-
4F2S
4
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
66
PsiBlast_CBE
85.86
50%
-15
- C3 -
-
4B9L
3
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
45
PsiBlast_CBE
85.86
50%
-14
- C3 -
-
1L3U
4
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
31
PsiBlast_CBE
85.86
50%
-14
- C3 -
-
1NKB
2
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
56
PsiBlast_CBE
85.84
50%
-13
- C3 -
-
4DQI
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
67
PsiBlast_CBE
85.80
50%
-17
- C3 -
-
2XO7
2
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
90
PsiBlast_CBE
85.79
50%
-12
- C3 -
-
3THV
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
65
PsiBlast_CBE
85.80
50%
-16
- C3 -
-
4B9M
2
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
82
PsiBlast_CBE
85.78
50%
-14
- C3 -
-
4EZ6
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
38
PsiBlast_CBE
85.79
50%
-17
- C3 -
-
1NK0
2
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
77
PsiBlast_CBE
85.78
50%
-13
- C3 -
-
4F2S
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
78
PsiBlast_CBE
85.74
50%
-13
- C3 -
-
4F2R
4
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
57
PsiBlast_CBE
85.72
50%
-12
- C3 -
-
4DQI
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
11
PsiBlast_PDB
85.72
50%
-14
- C3 -
-
3TAQ
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
58
PsiBlast_CBE
85.67
50%
-16
- C3 -
-
2XY7
3
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
73
PsiBlast_CBE
85.63
50%
-13
- C3 -
-
4F4K
4
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
9
PsiBlast_PDB
85.63
50%
-11
- C3 -
-
3TAN
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
10
PsiBlast_PDB
85.62
50%
-14
- C3 -
-
3TAP
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
69
PsiBlast_CBE
85.61
50%
-13
- C3 -
-
3EYZ
3
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
103
PsiBlast_CBE
85.54
50%
-11
- C3 -
-
2HVI
5
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
81
PsiBlast_CBE
85.53
50%
-16
- C3 -
-
4EZ9
3
?
A:
[15-591]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-
75
PsiBlast_CBE
85.52
50%
-14
- C3 -
-
4F3O
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
41
PsiBlast_CBE
85.51
50%
-16
- C3 -
-
1NJX
3
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
54
PsiBlast_CBE
85.47
50%
-12
- C3 -
-
4DQP
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
44
PsiBlast_CBE
85.47
50%
-13
- C3 -
-
1L3V
4
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
13
PsiBlast_PDB
85.43
50%
-17
- C3 -
-
4DQS
3
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
--------
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
99
PsiBlast_CBE
85.41
50%
-15
- C3 -
-
3PV8
3
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
48
PsiBlast_CBE
85.42
50%
-13
- C3 -
-
4DWI
6
?
A:
[4-581]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
14
PsiBlast_PDB
85.42
50%
-15
- C3 -
-
2HHQ
5
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
86
PsiBlast_CBE
85.40
50%
-13
- C3 -
-
4DSE
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
55
PsiBlast_CBE
85.41
50%
-15
- C3 -
-
4DQP
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
----
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
40
PsiBlast_CBE
85.40
50%
-13
- C3 -
-
1NJY
3
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
79
PsiBlast_CBE
85.32
50%
-11
- C3 -
-
4F2R
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
84
PsiBlast_CBE
85.31
50%
-12
- C3 -
-
4DSF
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
62
PsiBlast_CBE
85.32
50%
-17
- C3 -
-
4B9T
2
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
59
PsiBlast_CBE
85.31
50%
-14
- C3 -
-
2XY5
4
?
A:
[1-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
80
PsiBlast_CBE
85.30
50%
-13
- C3 -
-
4EZ9
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
53
PsiBlast_CBE
85.28
50%
-13
- C3 -
-
4DS4
2
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
19
PsiBlast_PDB
85.24
50%
-19
- C3 -
-
2HHX
4
DPO1_BACCA
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
-------
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
60
PsiBlast_CBE
85.22
50%
-17
- C3 -
-
4B9V
2
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
92
PsiBlast_CBE
85.20
50%
-11
- C3 -
-
3PX6
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
51
PsiBlast_CBE
85.18
50%
-13
- C3 -
-
4DS5
2
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
88
PsiBlast_CBE
85.15
50%
-11
- C3 -
-
3TI0
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
93
PsiBlast_CBE
85.14
50%
-12
- C3 -
-
3PX6
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
28
PsiBlast_CBE
85.09
50%
-15
- C3 -
-
1XC9
2
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
96
PsiBlast_CBE
85.02
50%
-13
- C3 -
-
3PX0
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
42
PsiBlast_CBE
85.02
50%
-14
- C3 -
-
1NJW
2
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
70
PsiBlast_CBE
84.99
50%
-15
- C3 -
-
4UQG
3
?
A:
[2-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
26
PsiBlast_CBE
84.98
50%
-13
- C3 -
-
4O0I
3
?
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
61
PsiBlast_CBE
84.97
50%
-18
- C3 -
-
4B9U
2
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
12
PsiBlast_PDB
84.96
50%
-13
- C3 -
-
3TAR
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
94
PsiBlast_CBE
84.93
50%
-11
- C3 -
-
3PX4
3
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
23
PsiBlast_CBE
84.89
50%
-13
- C3 -
-
4DSK
3
?
A:
[2-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
------
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
72
PsiBlast_CBE
84.81
50%
-13
- C3 -
-
4F8R
2
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
64
PsiBlast_CBE
84.81
50%
-15
- C3 -
-
4B9N
3
?
A:
[42-619]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
S
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
46
PsiBlast_CBE
84.80
50%
-12
- C3 -
-
1L3T
3
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
91
PsiBlast_CBE
84.78
50%
-13
- C3 -
-
3THV
3
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
89
PsiBlast_CBE
84.77
50%
-13
- C3 -
-
3TI0
3
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
100
PsiBlast_CBE
84.76
50%
-12
- C3 -
-
3EZ5
4
DPO1_GEOSE
D:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
102
PsiBlast_CBE
84.74
50%
-12
- C3 -
-
2HVI
4
?
D:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
22
PsiBlast_CBE
84.61
50%
-12
- C3 -
-
4DSL
2
?
A:
[2-579]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
21
PsiBlast_CBE
84.37
50%
-11
- C3 -
-
1LV5
4
DPO1_GEOSE
B:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
8
PsiBlast_PDB
84.36
50%
-11
- C3 -
-
1LV5
4
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
-
P
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
101
PsiBlast_CBE
84.26
50%
-11
- C3 -
-
3EZ5
4
DPO1_GEOSE
A:
[3-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
-
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
50
PsiBlast_CBE
83.98
50%
-12
- C3 -
-
4DS5
2
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
---------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
52
PsiBlast_CBE
83.71
50%
-13
- C3 -
-
4DS4
2
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
---------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
71
PsiBlast_CBE
83.54
50%
-16
- C3 -
-
4F8R
2
?
D:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
GD
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
---------------------------
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
97
PsiBlast_CBE
83.25
50%
-14
- C3 -
-
3PX0
4
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
-----------------------
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
95
PsiBlast_CBE
82.69
50%
-14
- C3 -
-
3PX4
3
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
-------------------------------
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
85
PsiBlast_CBE
80.59
50%
-14
- C3 -
-
4DSF
2
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
--------------------------------
N
Y
G
---
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
87
PsiBlast_CBE
80.05
50%
-13
- C3 -
-
4DSE
2
?
A:
[15-592]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
---
N
E
H
G
R
F
F
L
R
P
E
T
A
--------
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
--
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
-
G
V
D
D
V
A
A
A
A
K
M
--
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
-
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
--
L
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
--------------------------------
N
Y
G
---
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
110
HHSearch
76.35
51%
13
* C3 *
-
2HW3
4
?
A:
[23-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
--
E
H
G
R
F
F
L
R
P
E
T
A
---------
L
A
D
P
Q
F
V
A
W
L
--
G
D
ET
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
G
V
-
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
K
G
A
K
--
R
A
V
P
D
E
P
V
L
-
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
--
K
K
T
--
K
T
G
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
-
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
-
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
111
HHSearch
63.61
42%
31
- C3 -
-
4BWJ
3
DPO1_THEAQ
A:
[9-539]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
E
G
A
F
V
G
F
V
L
S
RKE
P
M
W
A
D
L
L
A
L
A
A
A
R
GG
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
--------
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
-
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
T
P
E
G
V
A
R
R
--
Y
G
G
E
----------------------
W
-
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
M
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
--
G
K
T
E
K
T
G
K
R
S
T
R
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
-
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
-
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
F
H
T
E
T
A
S
W
M
F
G
V
P
-
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
--
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K