@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0034: (2017-12-14 )
MSFLSKNGAGILACLLISILSWYLGGFFPVIGAPVFAIFIGMLLHPFLSSYKQLDAGLTFSSKKLLQYAVVLLGFGLNISQVFAVGQSSLPVILSTISIALIIAYLFQRFFALDTKLATLVGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVLAALIFPTLGTWLHLSNEGFALFAGTAVNDTSSVTAAASAWDSLYQSNTLESATIVKLTRTLAIIPITLFLSYWQSRQQENKQSLQLKKVFPLFILYFILASLLTTLLTSLGVSSSFFTPLKQLSKFLIVMAMSAIGLKTNLVAMVKSSGKSILLGAICWIAIILTTLGMQTLIGIF
Atome Classification :
(20 SA)
--------------------------------------.........10.......------.20--..---..----..-..-.-----30------------.-----.......40..-----------------..--..---------..50-....-.--..----.-.-----60....----..----..70.----...-....---80-.....-.--..--.90.---------------------.-..-....100----.........-110-....--...------..120--.---------.----.....130.........----140-...---...-.-.-.150----...------.----....160..------...-------..----170.......----180------------.....-...---190----.-..----....200..----.....210-----....--...----.220..------.....230---------------.........240....-...250.--------......260--.......------.270.......280..----.------..----..290...------..-..300.....--..310------..---.....320--.--------------------------------......330....------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------MSFLSKNG
A
G
I
L
A
C
L
L
I
S
------
I
L
---
S
W
---
Y
L----G
G
-
F
F
-
P
-----VI------------G-----
A
P
V
F
A
I
F
I
G
M
L
-----------------
L
H
--
P
F
---------
L
S
S
--
Y
K
Q
L
-D--AG----L-T-----
F
S
S
K
K
L
----
L
Q
----
Y
A
V
V
L
----
L
GF-GL
N
I
---
S
--
Q
V
F
A
V-G--QS--S
L
P
V
---------------------
I
-
L
S
-
T
I
S
I
A
------
L
I
I
A
Y
L
F
Q
R
-
F
---
F
A
L
D
--
T
K
L
------
A
T
L
V
G--V---------G----SSICGG--SAIAATA
P
V
----
I
---H
A
K
---
E
K
E
-
V
-
A
-
Q
A
I
-----
S
V
I
------
F
----
F
F
N
V
L
A
A
L
I
------
F
PT-------L
G
----
T
W
L
H
LSNE
G
F
----
A
L
-------------
F
A
GTA-VND---TS
S
----
V
-
T
A
----
A
A
S
A
W
D
S
L
Y
----QSNTLES------
A
T
I
V
--
K
L
T
----
R
T
L
A
I
I
------
P
I
T
L
F
L
-----------------
S
Y
W
Q
S
R
Q
QE
N
K
Q
S
L
Q
L
-
K
K
V
F
P
L
F
--------
I
L
Y
F
I
L
A
S
---
L
L
T
T
L
L
T
------SLGVS
S
S
F
F
T
P
L
K
Q
L
S
----
K
------
F
L
----
I
V
M
A
M
S
A
I------GL-K
T
N
L
V
A
M
V
K
S--SGK
S
I
------
L
L
---
G
A
I
C
W
I
A
I
--
I
--------------------------------
L
T
T
L
G
M
Q
T
L
IGIF------------------------------------
33
Fugue
71.48
17%
-149
* C5 *
-
3WZM
-
?
A:
[15-278]
--------------------------------------
M
R
T
R
S
T
I
S
T
P
-------
N
------
G
I
---
T
W
---
Y
Y
----
E
Q
-
E
G
-
T
-------------------
G
-----
P
D
V
V
L
V
P
D
G
----------------------------------
L
G
E
--
C
Q
M
F
-
D
--
S
S
----
V
-
S
-----
Q
I
A
A
Q
G
----
F
R
----
V
T
T
F
D
----
M
-
P
-
G
M
S
R
---
S
--
A
---------
K
--
A
P
P
E
---------------------
T
-
Y
T
-
E
V
T
A
Q
------
K
L
A
S
Y
V
I
S
V
-
L
---
D
A
L
D
--
I
K
H
------
A
T
V
W
G
--
C
---------
A
------------
S
G
A
S
T
V
V
A
L
----
L
---
L
G
Y
---
P
D
R
-
I
-
R
-
N
A
M
-----
C
H
E
------
L
----
P
T
K
L
L
---------------------------------------------------------------------------------------
D
H
L
S
----
N
T
A
V
L
E
D
------
E
E
I
S
--
K
I
L
----
A
N
V
M
L
N
------
D
V
S
G
G
S
-----------------
E
A
W
Q
A
--
M
G
D
E
V
H
A
R
L
-
H
K
N
Y
P
V
W
--------
A
R
G
Y
P
--------
R
T
I
P
P
------
S
A
P
V
K
D
-----
L
E
A
L
R
GKP
L
D
------
W
T
----
V
G
A
A
T
P
T
E
------
S
F
-
F
D
N
I
V
T
A
T
K
A
--
G
V
N
I
G
------
L
L
---
P
G
M
H
F
P
Y
V
--
S
--------------------------------
H
P
D
V
F
A
K
Y
V
V
E
T
T
Q
K
H
L--------------------------------
38
Fugue
61.79
15%
-35
- C2 -
-
4X4W
3
TRNT1_HUMAN
A:
[1-409]
-----------------------------------M
F
T
M
K
L
Q
S
P
E
F
Q
S
L
F
T
E
G
L
K
S
------
L
T
---
E
L
---
F
V
K
E
--
N
H
-
E
L
-
R
-----
I
A
------------
G
-----
G
A
V
R
D
L
L
N
G
V
K
-----------------
P
Q
D
I
D
F
---------
A
T
T
--
A
T
P
T
-
Q
--
M
K
----
E
-
M
-----
F
Q
S
A
G
I
----
R
M
I
NG
T
I
T
A
R
L
----
H
E
E
-
N
F
E
I
---
T
--
T
L
R
I
D
-
V
--
T
T
--
D
G
A
E
---------------------
V
-
E
F
-
T
T
D
W
Q
------
K
D
A
E
R
---
R
-
D
---
L
T
I
N
--
S
M
F
------
L
G
F
D
G
--
T
---------
L
----
F
D
Y
F
N
G
--
Y
E
D
L
K
N
K
K
V
----
R
FVG
H
A
K
---
Q
R
I
-
Q
-
E
-
D
Y
L
-----
R
I
L
------
R
----
Y
F
R
F
Y
G
R
I
V
DKPGDH
D
P
E
-------
T
L
----
E
A
I
A
E
N
A
K
G
L
----
A
G
-------------
I
S
G
E
R
-
I
W
V
---
E
L
K
----
K
-
I
L
V
GNH
V
N
H
L
I
H
L
I
Y
----
D
L
D
V
A
P
Y
IGLPAN
A
S
L
E
--
E
F
D
----
K
V
S
K
N
V
DGFSPK
P
V
T
L
L
A
-----------------
S
L
F
K
V
Q
D
D
V
T
K
L
D
L
R
L
-
K
I
A
K
E
E
K
--------
N
L
G
L
F
I
V
K
---
N
R
K
D
L
I
K
------
A
T
D
S
S
D
----
P
L
K
P
Y
Q
----
D
------
F
I
----
I
-----
D
S
------
D
A
-
T
T
R
V
C
E
L
L
K
Y
--
Q
G
E
H
C
------
L
L
---
K
E
M
Q
Q
W
S
I
PP
F
--------------------------------
P
V
S
G
H
D
I
R
K
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
GYQME
K
D
E
L
L
S
Y
I
K
K
T
L
10
HHSearch
61.59
14%
-131
- C4 -
-
5A1S
4
?
D:
[55-375]
------------------------------------------------
F
A
L
M
F
V
M
G
------
A
I
---
F
G
---
E
I
----
G
K
-
R
L
-
P
I
F
N
--
K
Y
I-----------
G
G----
A
P
V
M
I
F
L
V
A
A
Y
-----------------
F
V
--
Y
A
---------
G
I
F
--
T
Q
K
E
-
I
--
D
A
----
I
S
N
V
M
DKS
N
F
L
N
L
F
----
I
A
----
V
L
I
T
G
----
A
I
L
-
S
V
N
R
---
K
--
L
L
L
K
S
-
L
--
L
G
--
Y
I
P
T
---------------------
I
-
L
A
-
G
I
V
G
A
------
S
L
F
G
I
V
I
G
L
-
C
---
F
G
I
P
--
V
D
R
------
I
M
M
L
Y
--
V
---------
L
----
P
I
M
G
G
G
NG
A
G
A
V
P
L
S
E
I
Y
H
S
V
T
---
G
R
S
---
R
E
E
Y
Y
-
S
-
T
A
I
-----
A
I
L
------
T
----
I
A
N
I
F
A
I
I
F
------
A
A
L
-------
L
D
----
M
V
G
K
K
Y
T
--------
W
-------------
L
S
G
E
G
E
L
V
R
---
K
A
S
----
F
-
K
-----
T
---
E
D
--------
D
E
K
A
G
Q
------
I
T
H
R
--
E
T
A
----
V
G
M
V
L
S
------
T
T
C
F
L
L
-----------------
A
Y
V
V
A
K
K
I
L
-
P
--
S
I
G
-
G
V
S
I
H
Y
F
--------
A
W
M
V
L
I
V
A
---
A
L
N
A
S
G
L
---------
C
S
P
E
I
K
A
G
A
K
R
L
S
----
D
------
F
F
S
K
QL
L
W
V
L
M
V
G
V
------
G
V
C
Y
T
D
L
Q
E
I
I
D
A
L-
T
F
A
N
V
------
V
I
---
A
A
I
I
V
V
G
A
--
V
--------------------------------
V
------------------------------------------------
11
HHSearch
58.47
14%
-128
- C4 -
-
5A1S
3
?
C:
[55-375]
------------------------------------------------
F
A
L
M
F
V
M
G
------
A
I
---
F
G
---
E
I
----
G
K
-
R
L
-
P
IFN--
K
Y
I-----------
G
G----
A
P
V
M
I
F
L
V
A
A
Y
-----------------
F
V
--
Y
A
---------
G
I
F
--
T
Q
K
E
-
I
--
D
A
----
I
S
N
V
M
DKS
N
F
L
N
L
F
----
I
A
----
V
L
I
T
G
----
A
I
L
-
S
V
N
R
---
K
--
L
L
L
K
S
-
L
--
L
G
--
Y
I
P
T
---------------------
I
-
L
A
-
G
I
V
G
A
------
S
L
F
G
I
V
I
G
L
-
C
---
F
G
I
P
--
V
D
R
------
I
M
M
L
Y
--
V
---------
L
----
P
I
M
G
G
G
NG
A
G
A
V
P
L
S
E
I
Y
H
S
V
T
---
G
R
S
---
R
E
E
Y
Y
-
S
-
T
A
I
-----
A
I
L
------
T
----
I
A
N
I
F
A
I
I
F
------
A
A
L
-------
L
D
----
M
V
G
K
K
Y
T
--------
W
-------------
L
S
G
E
G
E
L
V
R
---
K
A
S
--------------------------
D
E
K
A
G
Q
------
I
T
H
R
--
E
T
A
----
V
G
M
V
L
S
------
T
T
C
F
L
L
-----------------
A
Y
V
V
A
K
K
I
L
-
P
--
S
I
G
-
G
V
S
I
H
Y
F
--------
A
W
M
V
L
I
V
A
---
A
L
N
A
S
G
L
---------
C
S
P
E
I
K
A
G
A
K
R
L
S
----
D
------
F
F
S
K
QL
L
W
V
L
M
V
G
V
------
G
V
C
Y
T
D
L
Q
E
I
I
D
A
L-
T
F
A
N
V
------
V
I
---
A
A
I
I
V
V
G
A
--
V
--------------------------------
V
------------------------------------------------
30
Fugue
52.95
21%
-47
* C3 *
-
2I3O
-
?
D:
[2-516]
-------------FRSRPNALSQRSVIASSSELASLAG
R
D
I
L
K
R
G
G
N
I
F
D
A
A
L
A
V
S
------
A
L
CVT
Q
N
---
N
L
CGLG
G
D
-
L
F
-
A
-----
L
I
RDENGQIDLNGS
G
-----
Q
A
S
R
A
V
S
I
D
Y
Y
ESGLTKIPERGPYAAIT
V
P
--
G
I
---------
A
G
S
--
W
D
E
I
-
F
--
R
K
----
F
-
A
-----
T
D
I
A
D
I
----
L
E
----
P
A
I
R
T
----
A
S
A
-
G
F
P
I
---
T
--
Q
N
Y
S
D
-
S
I-
A
R
--
S
A
P
V
IGQYRGWSSIFPNGSVPVAGE
I
-
L
K
-
Q
P
D
L
A
------
E
S
F
R
L
S
E
E
G
-
F
R--
S
F
Y
D
--
G
S
L
------
A
D
I
I
I
--
A
---------
G
LEGT
G
S
P
L
S
D
--
R
D
L
R
V
Y
R
P
L
----
I
---
G
K
P
---
V
F
T
-
D
-
L
-
D
E
F
-----
R
I
Y
ETSPNS
Q
----
G
I
T
V
I
E
W
I
R
------
G
E
S
-------
H
G
YDSR
T
W
E
A
K
I
E
D
I
F
ETEE
A
Y
-------------
D
K
R
R
K
-
I
T
D
---
P
S
Y
----
N
-
I
A
----
Q
H
D
S
A
N
G
K
G
LPKR
D
H
N
D
I
G
D
------
T
T
Y
F
--
S
I
S
DSEG
R
S
V
S
I
I
------
Q
S
N
Y
G
F
GSGIVPKGTGFVLQNRG
S
Y
F
-
T
L
Q
R
D
H
P
N
A
L
P
G
-
K
R
T
F
H
T
L
AACVEKEH
D
L
Y
A
S
L
G
S
GGD
I
Q
P
Q
V
Q
Q
------
I
L
E
I
L
K
D
N
T
D
P
Q
A
I
L
D
----
K
PRWTEP
Y
T
----
I
Y
E
A
P
G
A
V
------
Y
V
E
S
E
E
L
Y
R
N
V
S
K
QI
S
G
R
K
V
------
V
L
RDV
S
Q
E
F
G
T
A
Q
--
I
--------------------------------
T
T
L
I
R
G
D
V
V
V
G
A
A
DPRGDGIAIPYS------------------------
35
Fugue
51.27
14%
-70
- C1 -
-
4XGC
-
ORC5_DROME
E:
[1-458]
M
E
A
I
C
S
S
L
E
PLFPCR
E
A
A
I
E
T
L
G
E
L
IGDSSETYPS
A
I
Y
L
F
G
H
S
G
T
G
K
T
A
L
T
R
A
F
L
K
------
E
C
---
G
K
RQN
V
R
----
T
A
-
H
L
-
N
-----
A
I
------------
E
-----
C
Y
T
T
K
I
M
L
E
I
L
-----------------
L
D
--
S
L
A
PDQGDALK
V
D
N
--
M
L
D
F
-
V
--
E
Q
----
L
-
R
-----
R
Q
A
A
T
R
----
V
E
----
D
Q
G
F
L
----
I
A
V
-
D
-
N
A
---
E
--
R
L
R
D
M
-
D
--
A
N
--
V
L
P
V
---------------------
L
-
L
R
-
L
Q
E
L
T
NLN
L
C
V
I
L
L
S
Q
L
P
F
E
-
K
---
F
Y
N
K
--
T
G
L
------
S
E
I
V
C
--
L
H
L
A
Q
YN
K
A
E
T
----
Q
R
I
L
G
S
--
D
F
Q
Q
V
R
N
Q
L
----
L
E
--
Q
K
K
---
R
L
E
-
I
-
C
-
Q
E
A
-----
V
T
E
------
D
----
F
Y
N
N
Y
L
N
L
F
------
L
S
V
F
YKACRD
V
P
----
E
L
Q
L
T
A
R
K
C
L
----
S
T
-------------
Y
L
E
P
V
-
L
D
G
---
T
S
R
----
L
W
R
H
----
I
A
G
P
L
R
S
A
L
----
T
Q
I
Y
M
R
I
------
E
S
L
E
--
L
P
Y
----
Y
A
K
F
L
L
------
I
A
A
F
L
A
-----------------
S
H
N
A
A
K
Q
D
K
R
L
F
S
T
T
L
G
P
K
S
F
S
I
D
--------
R
L
L
A
I
F
Y
A
---
I
L
E
E
---------
K
V
G
L
T
C
N
L
L
S
Q
I
S
T
L
V
----
H
------
L
N
----
L
L
S
F
V
S
G
E
------
Q
N
-
I
M
E
G
S
A
R
L
Q
C
--
T
---
I
------
G
L
---
E
F
V
L
Q
I
G
K
--
V
--------------------------------
V
G
F
N
V
R
Q
Y
L
C
D
--------------------------------------
37
Fugue
47.93
12%
-44
- C5 -
-
3R2U
-
?
A:
[23-370]
----------------------NA
M
F
F
K
Q
F
Y
D
KHLS
Q
A
S
Y
L
I
G
C
Q
K
T
G
E
A
M
I
I
D
P
I
------
R
D
---
L
S
---
S
Y
----
I
R
-
V
A
-
D
-----
E
E
------------
G
-----
L
T
I
T
H
A
A
E
T
H
I
-----------------
H
A
--
D
F
---------
A
S
G
--
I
R
D
V
-
A
--
I
K
LN
A
N
I
-
Y
-----
V
S
G
E
S
D
----
D
T
----
L
G
Y
K
N
----
M
P
N
-
H
T
H
F
VQH
N
--
D
D
I
Y
V
-
G
--
N
I
--
K
L
K
V
---------------------
L
-
H
T
-
P
G
H
T
P
------
E
S
I
S
F
L
L
T
D
-----
E
G
A
G
--
A
Q
V
------
P
M
G
L
F
--
S
---------
G
----
D
F
I
F
V
G
--
D
-
I
G
R
P
D
L
L
----
E
---
K
A
V
---
K
V
E
-
G
-
S
-
S
E
I
-----
G
A
K
------
Q
----
M
F
K
S
I
E
S
I
K
-------
D
L
-------
P
D
----
Y
I
Q
I
W
P
G
H
G
A
----
G
S
-------------
P
C
G
K
S
-
L
G
A
---
I
P
T
----
S
-
T
L
----
G
Y
E
K
Q
T
N
W
A
----
F
S
E
N
N
E
A
------
T
F
I
D
--
K
L
I
----
S
D
Q
P
A
P
------
P
--
H
H
F
-----------------
A
Q
M
K
K
I
N
Q
F
G
M
N
L
Y
Q
P
-
Y
T
V
Y
P
A
T
--------
N
T
N
R
L
T
F
D
---
L
R
S
K
E
A
Y
------
H
G
G
H
I
E
G
T
I
N
I
--
P
Y
D
----
K
------
N
F
----
I
N
Q
I
G
W
Y
L
------
N
Y
-
D
Q
E
I
N
L
I
G
D
---------------
Y
---
H
L
V
S
K
A
T
H
--
T
--------------------------------
L
Q
L
I
G
Y
D
D
I
A
G
Y
Q
L
P
Q---------------------------------
16
HHSearch
46.55
16%
-170
- C4 -
-
4CZ8
2
?
A:
[29-172]
-------------------------------------------------------------------------------------------
I
------------
S
-----
Y
V
P
I
F
I
L
T
G
L
V
-----------------
I
G
--
P
L
---------
L
K
L
I-
P
R
D
L
A
H
--
E
I
----
F
-
D
-----
F
V
R
V
F
G
----
L
V
----
I
I
L
F
T
----
E
G
H
-
N
L
S
W
---
R
--
L
L
K
K
N
-
M
--
P
T
--
I
V
T
L
---------------------
D
-
T
I
-
G
L
I
L
T
------
A
L
I
A
G
F
I
F
K
V
V
---
F
N
S
S
--
F
L
L
------
G
F
L
F
G
--
A
----------------
I
I
G
A
--
T
D
P
A
T
L
I
P
L
----
F
---
R
Q
Y
RV-
K
Q
D
-
I
E
T
-
V
I
V
-----
T
E
S
------
I
----
F
N
D
P
L
G
I
V
L
------
T
L
I
-------
A
I
----
S
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
46.53
15%
-172
- C4 -
-
3ZUY
6
?
A:
[15-150]
---------------------------------------------------------------------------------------------------------------
F
S
L
W
A
A
L
F
A
A
-----------------
A
A
--
F
F
---------
A
----
P
D
T
F
-
K
---
W
----
A
-
G
-----
P
Y
I
P
W
L
----
L
G
----
I
I
M
F
G
----
M
G
L
-
T
L
K
P
---
S
--
D
F
D
I
L
-
F
--
K
H
P
K
V
V
I
I
---------------------
G
-
V
I
A
Q
F
A
I
M
------
P
A
T
A
W
L
L
S
K
-
L
---
L
N
L
P
--
A
----------
E
I
A
--
V
---------
G
----
V
I
L
V
G
C
--
C
P
G
G
T
A
S
N
V
----
M
---
T
Y
L
A
--
R
G
N
-
V
-
A
-
L
S
V
-----
A
V
T
------
S
----
V
S
T
L
I
S
P
L
L
------
T
P
A
-------
I
F
----
L
M
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
46.43
19%
-137
- C4 -
-
4CZB
-
NAH1_METJA
A:
[29-175]
-------------------------------------------------------------------------------------------
I
------------
P
-----
D
I
P
L
L
L
L
L
G
L
I
-----------------
I
G
--
P
F
---------
L
Q
I
IP
S
D
S
A
-
M
--
E
I
----
F
-
E
-----
Y
A
G
P
I
G
----
L
I
----
F
I
L
L
G
----
G
A
F
-
T
M
R
I
---
S
--
L
L
K
R
V
-
I
--
K
T
--
V
V
R
L
---------------------
D
-
T
I
-
T
F
L
I
T
------
L
L
I
S
G
F
I
F
N
M
V
---
L
N
L
P
YT
S
P
V
------
G
Y
L
F
G
--
A
----------------
I
T
A
A
--
T
D
P
A
T
L
I
P
V
----
F
---
S
R
V
RT-
N
P
E
-
V
-
A
I
T
L
E
-----
A
E
S
------
I
----
F
N
D
P
L
G
I
V
S
------
T
S
V
-------
I
L
----
G
L
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
45.90
19%
-43
- C3 -
-
5CX8
5
?
A:
[10-481]
------------------------------DFQQPYTS
F
V
Q
T
K
Q
N
R
D
G
L
Y
A
L
L
R
N
T
ENPRMH
F
Y
---
Q
E
---
L
Q
----
S
D
M
Y
C
-
T
-----
T
I
------------
T
DGNSL
A
P
F
V
N
W
D
L
G
I
L
-----------------
N
D
--
H
G
---------
R
A
D
--
E
D
E
V
-
S
G
I
A
G
----
Y
-
Y
-----
F
V
Y
N
R
L
----
N
Q
----
Q
A
N
A
F
----
V
N
N
-
T
E
A
A
---
L
Q
N
Q
V
Y
K
N
-
S
--
T
E
--
I
A
N
A
---------------------
K
-
S
F
-
L
A
E
G
K
------
V
L
Q
A
L
A
I
W
R
-
L
M
D
R
F
S
F
H
--
E
S
V
TEVNSG
A
K
D
L
G
--
V
ILLKEYN--
P
----
G
Y
I
G
P
R
--
A
T
K
A
Q
C
Y
D
Y
----
I
---
L
S
R
---
L
S
E
-
A
-
I
-
E
V
L
PENRE
S
V
L
------
Y
VS
R
D
Y
A
Y
A
L
R
A
R
I
------
Y
L
A
-------
L
G
----
E
Y
G
K
A
A
A
D
A
K
M
---
V
V
DKYPLIGAAD
A
S
E
F
E
N
I
Y
-
R
S
D
---
A
N
N
PEII
F
-
R
G
----
F
A
S
A
T
L
G
S
F
----
T
A
T
T
L
N
G
------
A
A
P
A
GK
D
I
K
----
Y
N
P
S
A
V
------
P
F
Q
W
V
V
-----------------
D
L
Y
E
N
--
E
D
F
R
K
S
V
Y
I
-
A
K
V
V
K
K
D
--------
K
G
Y
L
V
N
K
F
---
L
E
D
K
A
Y
R
DVQDKP
N
L
K
V
G
A
R
Y
F
S
----
V
A
----
E
------
V
Y
----
L
I
L
V
E
S
A
L
Q
T
GD
T
P
T
A
-
E
K
Y
L
K
A
L
S
K
A
--
R
G
A
E
V
SVVN
M
E
A
L
---
Q
A
E
R
T
R
E
L
--
I
GEGS
R
L
R
D
M
V
R
W
SIPNNHDAFETQPGLEGFAN
T
T
P
L
K
A
Q
A
P
V
G
F
Y
AYTWEFP
Q
R
D
R
Q
T
N
PQ
L
I
K
N
W
PI-------------
20
HHSearch
45.06
15%
-142
- C4 -
-
4N7W
1
?
A:
[31-145]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
P
Y
V
G
P
L
----
L
M
----
L
I
M
F
A
----
M
G
V
-
T
L
R
L
---
D
--
D
F
K
R
V
-
L
S
R
P
A
--
P
V
A
A
---------------------
A
T
F
L
-
H
Y
L
I
M
------
P
L
T
A
W
I
L
A
M
-
L
---
F
R
M
P
--
P
D
L
----------
S
--
A
---------
G
----
M
V
L
V
G
S
--
V
A
S
G
T
A
S
N
V
----
M
---
I
Y
L
A
--
K
G
D
-
V
-
A
-
L
S
V
-----
T
I
S
------
A
----
V
S
T
L
V
G
V
F
A
------
T
P
L
-------
L
T
----
R
L
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
43.81
19%
-137
- C4 -
-
4D0A
-
NAH1_METJA
B:
[29-175]
-------------------------------------------------------------------------------------------
I
------------
P
-----
D
I
P
L
L
L
L
L
G
L
I
-----------------
I
G
--
P
F
---------
L
Q
I
IP
S
D
S
A
-
M
--
E
I
----
F
-
E
-----
Y
A
G
P
I
G
----
L
I
----
F
I
L
L
G
----
G
A
F
-
T
M
R
I
---
S
--
L
L
K
R
V
-
I
--
K
T
--
V
V
R
L
---------------------
D
-
T
I
-
T
F
L
I
T
------
L
L
I
S
G
F
I
F
N
M
V
---
L
N
L
P
YT
S
P
V
------
G
Y
L
F
G
--
A
----------------
I
T
A
A
--
T
D
P
A
T
L
I
P
V
----
F
---
S
R
V
RT-
N
P
E
-
V
-
A
I
T
L
E
-----
A
E
S
------
I
----
F
N
D
P
L
G
I
V
S
------
T
S
V
-------
I
L
----
G
L
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
43.63
17%
-148
- C4 -
-
3ZUX
6
?
A:
[43-155]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
I
P
W
L
----
L
G
----
I
I
M
F
G
----
M
G
L
-
T
L
K
P
---
S
--
D
F
D
I
L
-
F
K
H
P
K
--
V
V
I
I
G
--------------------
V
-
I
A
-
Q
F
A
I
M
------
P
A
T
A
W
C
L
S
K
-
L
---
L
N
L
P
--
A
E
----------
I
A
--
V
---------
G
----
V
I
L
V
G
C
--
C
P
G
G
T
A
S
N
V
----
M
---
T
Y
L
A
--
R
G
N
-
V
-
A
-
L
S
V
-----
A
V
T
------
S
----
V
S
T
L
T
S
P
L
L
------
T
P
A
-------
I
F
----
L
M
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
42.57
16%
-122
- C4 -
-
5BZ3
4
?
A:
[28-169]
-------------------------------------------------------------------------------------------
Q
------------
P
-----
V
V
I
G
E
V
L
A
G
V
L
-----------------
V
G
--
P
A
---------
L
L
----
G
L
V
-
H
--
E
-----
G
-------
E
I
L
E
F
L
----
A
E
----
L
G
A
V
F
L
L
F
M
V
G
L
-
E
T
R
L
---
K
--
D
I
L
A
V
-
G
--
K
E
--
A
F
L
V
---------------------
A
-
V
L
-
G
V
A
L
P
------
F
L
G
G
Y
L
Y
G
L
-
E
---
I
G
F
E
--
T
L
P
------
A
L
F
L
G
--
T
---------------
A
L
V
A
T
--
S
V
G
-
I
T
A
R
V
----
L
---
Q
E
L
GVL
S
R
P
Y
S
-
R
-
I
I
L
-----
G
A
A
------
V
----
I
D
D
V
L
G
L
I
V
------
L
A
C
-------
V
N
----
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
37.95
15%
-161
- C4 -
-
2L9U
-
ERBB3_HUMAN
A:
[637-676]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
G
R
T
H
L
T
M
------
A
L
T
V
--
I
A
G
----
L
V
V
I
F
M
------
M
L
G
G
T
F
-----------------
L
Y
W
R
G
R
R
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
36.76
11%
-126
- C4 -
-
5A1S
2
?
C:
[269-431]
---------------------------------------------
A
V
G
M
V
L
S
T
T
C
F
------
L
L
---
A
Y
---
V
V
----
A
K
-
K
I
L
P
SIGG
V
S
I
------------
H
-----
Y
F
A
W
M
V
L
I
V
A
A
-----------------
L
N
A
S
G
L
---------
C
----
S
P
E
I
-
K
--
A
G
----
A
-
K
-----
R
L
S
D
F
F
S
K
QL
L
W
----
V
L
M
V
G
----
V
G
V
C
Y
T
D
L
---
Q
--
E
I
I
D
A
L
T
--
F
A
--
N
V
V
I
---------------------
A
-
A
I
-
I
V
V
G
A
------
V
V
G
A
A
I
G
G
W
-
L
---
I
G
F
Y
--
P
I
E
------
S
S
I
T
A
GL
C
---------
M
----
A
N
R
G
G
S
--
G
D
L
E
V
L
S
A
C
----
N
-----
R
---
M
N
L
-
I
-
S
-
Y
A
Q
-----
I
S
S
------
R
----
L
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
35.38
18%
-132
- C4 -
-
5BZ3
2
?
A:
[234-338]
-------------------------------------------------------------------------------------------
L
------------
A
-----
P
I
V
G
A
F
L
G
G
M
L
-----------------
L
S
--
E
V
---------
R
E
K
---
Y
R
L
-
E
--
E
P
----
I
-
F
-----
A
I
E
S
F
L
----
A
P
----
I
F
F
A
M
----
V
G
V
-
R
L
E
L
---
S
--
A
L
A
S
P
-
V
V
L
V
A
--
G
T
V
V
---------------------
T
-
V
I
-
A
I
L
G
K
------
V
L
G
G
F
L
G
A
L
------
T
Q
G
--
V
R
S
------
A
L
T
V
G
--
C
---------
G
----
M
A
P
R
G
E
--
V
G
L
I
V
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
34.71
40%
-34
- C6 -
-
2YVQ
-
CPSM_HUMAN
A:
[1375-1432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
----
V
A
E
Q
L
H
N
E
G
F
----
K
L
-------------
F
A
T
E
A
-
T
S
D
W
L
N
A
N
N
----
V
-
P
A
----
T
P
V
A
W
P
S
Q
E
---------
L
S
-------
S
I
R
--
K
L
I
----
R
D
G
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
33.94
11%
-132
- C4 -
-
5A1S
4
?
D:
[269-431]
---------------------------------------------
A
V
G
M
V
L
S
T
T
C
F
------
L
L
---
A
Y
---
V
V
----
A
K
-
K
I
L
P
SIGG
V
S
I
------------
H
-----
Y
F
A
W
M
V
L
I
V
A
A
-----------------
L
N
A
S
G
L
---------
C
----
S
P
E
I
-
K
--
A
G
----
A
-
K
-----
R
L
S
D
F
F
S
K
QL
L
W
----
V
L
M
V
G
----
V
G
V
C
Y
T
D
L
---
Q
--
E
I
I
D
A
L
T
--
F
A
--
N
V
V
I
---------------------
A
-
A
I
-
I
V
V
G
A
------
V
V
G
A
A
I
G
G
W
-
L
---
I
G
F
Y
--
P
I
E
------
S
S
I
T
A
GL
C
---------
M
----
A
N
R
G
G
S
--
G
D
L
E
V
L
S
A
C
----
N
-----
R
---
M
N
L
-
I
-
S
-
Y
A
Q
-----
I
S
S
------
R
----
L
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------