@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0035: (2017-12-14 )
MDLTKRFNKQLDKIQVSLIRQFDQVISEIPGVLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPATFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA
Atome Classification :
(26 SA)
.........10........20...----.....30........40........50........60........70........80........90........100.......110.......120.......130...-..--..140..-..-...150.......160.......170.......180.......190.......200.......210....----...220-..--.---.....230.......240.......250.......260.......270.......280.---..--..--..290.......300.......310........320.....-..-330.-......340..------.....350......--.360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
D
L
T
K
R
F
N
K
Q
L
D
K
I
Q
V
S
L
I
R
Q
F
D
Q
----
V
I
S
EIP
G
V
L
R
L
TLGEPDFT
T
P
D
H
V
K
E
A
A
K
R
A
IDQNQ
S
Y
Y
T
G
M
S
G
L
L
T
L
R
Q
A
A
S
D
F
V
K
E
K
Y
QLDYAPEN
E
I
L
V
T
IG
A
T
E
A
L
S
A
T
L
T
A
I
L
EEG
D
K
V
L
L
PAPAYP
G
Y
E
P
I
V
N
LV-G
A
--
E
I
V
E
I
DT-TE-N
G
F
V
L
T
P
E
M
L
E
K
A
I
L
EQGD
K
L
K
A
V
I
L
NYPANPTGITY
S
R
E
Q
L
E
A
L
A
A
V
L
R
KY
E
I
F
V
V
C
D
E
V
Y
SELTYTGE----
A
H
V
S
L
--
G
T
--
M
---LRD
Q
A
I
I
I
NGLSKSHAM
T
G
W
R
L
G
L
I
FA
P
A
T
F
T
A
Q
L
I
KSH
Q
Y
L
V
T
A
A
N
T
M
A
Q
H
A
A
V
E
A
L
T---AG--KN--D
A
E
P
M
K
K
E
Y
I
Q
R
R
D
Y
I
I
E
K
M
T
AL-G
F
E
I
IKPDG
A
F
Y
I
F
A
KI-PA-GYNQ-
D
S
F
A
F
L
K
D
F
A
Q------KK
A
V
A
FIPGAAFGR--YG
E
G
Y
V
R
L
S
Y
A
A
S
M
E
T
I
K
E
A
M
K
R
L
E
E
Y
M
REA
64
HHSearch
96.88
77%
-59
- C1 -
-
4MY5
-
?
A:
[1-388]
M
D
L
S
K
R
F
N
K
N
L
N
K
I
E
V
S
M
I
R
Q
F
D
Q
----
S
I
S
D
I
P
D
V
L
K
L
T
L
G
E
P
D
F
A
T
P
K
H
I
K
E
A
A
K
R
A
I
D
A
D
E
S
H
Y
T
G
M
A
G
L
L
A
L
R
Q
A
A
S
A
F
V
K
E
K
Y
H
L
T
Y
N
P
D
N
E
I
L
V
T
I
G
A
T
E
A
L
S
A
S
L
T
A
I
L
E
P
G
D
K
V
L
L
P
A
P
A
Y
P
G
Y
E
P
V
V
N
L
V
-
G
A
--
E
V
V
E
I
D
T
-
R
S
-
N
D
F
V
L
T
P
E
M
L
E
E
A
I
L
K
E
G
E
A
L
K
A
V
I
L
N
Y
P
T
N
P
T
G
V
T
Y
S
R
Q
Q
I
K
N
L
A
E
V
L
K
K
Y
P
I
F
V
I
S
D
E
V
Y
A
E
L
T
Y
T
G
E
S---
H
-
V
S
I
A
-
E
Y
--
L
---
P
-
D
Q
T
I
L
I
S
G
L
S
K
S
H
A
M
T
G
W
R
L
G
L
I
F
A
P
A
V
L
T
A
Q
L
I
K
S
H
Q
Y
L
V
T
A
A
T
T
S
V
Q
F
A
A
I
E
A
L
T
---
N
G
--
K
D
--
D
A
L
P
M
K
E
E
Y
I
K
R
R
D
Y
I
I
E
K
M
E
A
M
-
K
F
K
I
I
K
P
D
G
A
F
Y
I
F
A
K
I
-
P
V
-
A
Q
G
Q
-
D
S
F
K
F
L
Q
D
F
A
K
------
E
K
A
V
A
F
I
P
G
V
A
F
G
K
--
Y
G
E
G
Y
L
R
I
S
Y
A
A
S
M
E
T
I
K
E
A
M
K
R
L
K
E
F
M
E
Q
-
63
HHSearch
73.13
38%
-45
* C1 *
-
1GDE
4
?
A:
[2-385]
-----
A
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
----
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
-
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
---
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
---
H
-
Y
S
I
A-
S
L
DG
M
---
F
-
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
R
S
W
K
--
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
-
R
D
T
G
L
T
S
---
K
K
F
S
E
L
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
-
23
PsiBlast_CBE
71.90
37%
-29
- C1 -
-
1GD9
2
?
B:
[3-385]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
----
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
Y
E
E
-
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
H
Y
S
I
--
A
S
--
L
DG-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
--
R
S
WK
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
L
T
S
-
K
K
F
S
E
L
--
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
-
3
PsiBlast_PDB
71.61
37%
-29
- C1 -
-
1GD9
2
?
A:
[3-385]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
----
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
Y
E
E
-
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
H
Y
S
I
--
A
S
--
L
DG-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
--
R
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
L
T
S
-
K
K
F
S
E
L
--
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
-
2
PsiBlast_PDB
71.07
37%
-29
- C1 -
-
1GDE
4
?
A:
[3-385]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
----
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
Y
E
E
-
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
H
Y
S
I
--
A
S
--
L
DG-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
--
R
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
L
T
S
-
K
K
F
S
E
L
--
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
-
22
PsiBlast_CBE
70.44
37%
-29
- C1 -
-
1GDE
4
?
B:
[3-385]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
----
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
Y
E
E
-
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
H
Y
S
I
--
A
S
--
L
DG-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
--
R
S
WK
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
L
T
S
-
K
K
F
S
E
L
--
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
-
17
PsiBlast_PDB
66.86
29%
-76
- C1 -
-
2X5D
1
?
A:
[39-396]
-----------------------------------
I
I
D
L
S
M
G
N
P
D
G
P
T
P
P
H
I
V
E
K
L
C
T
V
A
--------
T
S
R
G
I
P
R
L
R
R
A
I
S
H
W
Y
R
D
R
Y
D
V
Q
I
D
P
E
S
E
A
I
V
T
I
G
S
K
E
G
L
A
H
L
M
L
A
T
L
D
H
G
D
T
I
L
V
P
N
P
S
Y
P
I
H
I
Y
G
A
V
I
A
-
G
A
--
Q
V
R
S
V
P
L
-
V
P
--
G
I
D
F
F
N
E
-
L
E
R
A
I
R
E
S
I
P
K
P
R
M
M
I
L
G
F
P
S
N
P
T
A
Q
C
V
E
L
D
F
F
E
R
V
V
A
L
A
K
Q
Y
D
V
M
V
V
H
D
L
A
Y
A
D
I
V
Y
D
G
W
----
K
A
P
S
I
--
M
Q
--
V
PG-
A
K
D
I
A
V
E
F
F
T
L
S
-
S
Y
N
M
A
G
W
R
I
G
F
M
V
G
N
P
E
L
V
S
A
L
A
R
I
K
S
Y
H
D
Y
G
T
F
T
P
L
Q
V
A
A
I
A
A
L
E
---
G
D
--
Q
Q
--
C
V
R
D
I
A
R
Q
Y
Q
Q
R
R
D
V
L
V
K
G
L
R
E
A
-
G
W
M
V
E
N
P
K
A
S
M
Y
V
W
A
K
I
-
P
E
-
P
Y
A
H
L
G
S
L
E
F
A
K
K
L
L
Q
------
D
A
K
V
S
V
S
P
G
I
G
F
G
D
--
Y
G
D
D
H
V
R
F
A
L
I
E
N
R
D
R
L
R
Q
A
V
R
G
I
K
A
M
F
R
--
1
PsiBlast_PDB
65.36
37%
-30
- C1 -
-
1DJU
2
?
A:
[2-384]
------
L
S
D
R
L
E
L
V
S
A
-----------------
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
Y
E
E
-
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
H
Y
S
I
--
A
S
--
L
DG-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
--
R
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
L
T
S
-
K
K
F
S
E
L
--
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
-
21
PsiBlast_CBE
65.31
37%
-34
- C1 -
-
1DJU
2
?
B:
[2-384]
------
L
S
D
R
L
E
L
V
S
-------------------
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
--
K
P
V
E
V
P
T
Y
E
E
-
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
----
R
H
Y
S
I
--
A
S
--
L
DG-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
E
--
R
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
L
T
S
-
K
K
F
S
E
L
--
M
L
K
------
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
-
14
PsiBlast_PDB
64.97
33%
-50
- C1 -
-
1J32
2
?
A:
[32-385]
-----------------------------------
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
D
N
-
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
--
P
V
I
L
P
T
T
-
V
E
-
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
---
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
----
Q
H
L
S
I
--
G
A
--
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
---
N
S
--
Q
D
--
C
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
--
A
-
K
T
G
R
-
S
S
L
D
F
C
S
E
L
L
D
------
Q
H
Q
V
A
T
V
P
G
A
A
F
G
----
A
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
--
45
PsiBlast_CBE
64.03
33%
-49
- C1 -
-
1J32
2
?
B:
[32-385]
-----------------------------------
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
D
N
-
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
--
P
V
I
L
P
T
T
-
V
E
-
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
---
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
----
Q
H
L
S
I
--
G
A
--
A
SPE
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
---
N
S
--
Q
D
--
C
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
--
A
-
K
T
G
R
-
S
S
L
D
F
C
S
E
L
L
D
------
Q
H
Q
V
A
T
V
P
G
A
A
F
G
----
A
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
--
18
PsiBlast_PDB
63.23
29%
-68
- C1 -
-
1U08
2
YBDL_ECOLI
A:
[22-385]
--------------
Q
M
S
A
L
A
Q
Q
H
Q
----
A
I
N
-------
L
S
Q
G
F
P
D
F
D
G
P
R
Y
L
Q
E
R
L
A
H
H
V
A
Q
G
A
N
Q
Y
A
P
M
T
G
V
Q
A
L
R
E
A
I
A
Q
K
T
E
R
L
Y
G
Y
Q
P
D
A
D
S
D
I
T
V
T
A
G
A
T
E
A
L
Y
A
A
I
T
A
L
V
R
N
G
D
E
V
I
C
F
D
P
S
Y
D
S
Y
A
P
A
I
A
L
S
-
G
G
--
I
V
K
R
M
A
L
-
Q
P
-
P
H
F
R
V
D
W
Q
E
F
-
A
A
L
L
S
E
R
T
R
L
--
V
I
L
N
T
P
H
N
P
S
A
T
V
W
Q
Q
A
D
F
A
A
L
W
Q
A
I
A
G
H
E
I
F
V
I
S
D
E
V
Y
E
H
I
N
F
S
Q
Q
----
G
H
A
S
V
LA
H
P
--
Q
---
L
R
E
R
A
V
A
V
S
S
F
G
K
T
Y
H
M
T
G
W
K
V
G
Y
C
V
A
P
A
P
I
S
A
E
I
R
K
V
H
Q
Y
L
T
F
S
V
N
T
P
A
Q
L
A
L
A
D
M
L
R
---
A
E
--
P
E
--
H
Y
L
A
L
P
D
F
Y
R
Q
K
R
D
I
L
V
N
A
L
N
E
S
-
R
L
E
I
L
P
C
E
G
T
Y
F
L
L
V
D
Y
-
S
A
-
V
S
T
L
-
D
D
V
E
F
C
Q
W
L
T
Q
------
E
H
G
V
A
A
I
P
L
S
V
F
C
A
DP
F
P
H
K
L
I
R
L
C
F
A
K
K
E
S
T
L
L
A
A
A
E
R
L
R
Q
-----
26
PsiBlast_CBE
63.02
36%
-37
- C1 -
-
5BJ3
2
AAT_THET8
B:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
24
PsiBlast_CBE
62.89
36%
-37
- C1 -
-
5BJ3
2
AAT_THET8
D:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
4
PsiBlast_PDB
62.85
36%
-37
- C1 -
-
5BJ3
2
AAT_THET8
A:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
8
PsiBlast_PDB
62.10
36%
-38
- C1 -
-
1GCK
4
AAT_THET8
A:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
25
PsiBlast_CBE
62.05
36%
-37
- C1 -
-
5BJ3
2
AAT_THET8
C:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
9
PsiBlast_PDB
61.95
36%
-36
- C1 -
-
1B5P
2
AAT_THET8
A:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
7
PsiBlast_PDB
61.78
36%
-37
- C1 -
-
5BJ4
2
AAT_THET8
A:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
39
PsiBlast_CBE
61.53
36%
-39
- C1 -
-
1B5P
2
AAT_THET8
B:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
27
PsiBlast_CBE
61.23
36%
-37
- C1 -
-
5BJ4
2
AAT_THET8
B:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
38
PsiBlast_CBE
60.21
36%
-37
- C1 -
-
1GCK
4
AAT_THET8
B:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
40
PsiBlast_CBE
59.60
36%
-35
- C1 -
-
1B5O
2
AAT_THET8
B:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
AAERLL
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
10
PsiBlast_PDB
59.45
36%
-38
- C1 -
-
1B5O
2
AAT_THET8
A:
[36-382]
--------------------------------------
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
--
V
V
V
E
V
E
T
L
P
E
-
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
---
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
-----
H
F
S
P
--
G
R
--
V
---
A
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
A
--
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
----------
M
-
D
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
--
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
44
PsiBlast_CBE
59.20
34%
-3
- C1 -
-
1O4S
2
AAT_THEMA
B:
[15-386]
-------
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
-
G
G
T
V
N
V
V
E
T
F
M
-
S
K
-
N
---
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
-
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
FTSI
L
D
V
S
E
--
G
F
--------
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
---
V
-------
D
N
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
-
R
G
------
D
D
V
K
F
C
E
R
L
L
E
------
E
K
K
V
A
L
V
P
G
S
A
F
L
K
----
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
---
12
PsiBlast_PDB
56.54
34%
1
- C1 -
-
1O4S
2
AAT_THEMA
A:
[15-386]
-------
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
-
G
G
T
V
N
V
V
E
T
F
M
-
S
K
-
N
---
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
-
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
FTSI
L
D
V
S
E
--
G
F
--------
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
---
V
-------
D
N
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
-
R
G
------
D
D
V
K
F
C
E
R
L
L
E
------
E
K
K
V
A
L
V
P
G
S
A
F
L
K
----
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
---