@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0044: (2017-12-14 )
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGTSLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELSLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGTLLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
Atome Classification :
(20 SA)
--------....--.....10...--.....20....-------------....30-------.-----------.......40.....----...50........60-------........70........80...--...----------..90........100...-----------------.--...110.......120.......--130.---------..-----.-...140------........150.----------......160.......-170.......180...-..--.---.---190.......--.200.......210.......220......-----.-230....--------------...240.......250..-----------.....260....----------------------------...270..---------.....280----.......-----------.290.......--300.....--..310.....------------------..320....-...330...---.--...340.......350...---------....360....----..---------.370-........380...--....390.......400---.......410.......420-.......430--------..---.......440.......--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------M
K
P
E
--
F
L
E
S
A
E
F
Y
N
R
--
R
YHNFS
S
S
V
I
V
-------------
P
M
A
L
L
L
-------
V
-----------
F
L
L
G
F
A
T
V
A
E
K
EMS----LSTRATV
E
P
S
R
I
L
A
N
-------
I
QSTSN
N
R
I
L
V
N
HLEENKLVKKG--
D
L
L
----------
V
Q
YQEGAEGV
Q
A
E
S
Y
A
S
Q
-----------------
L
--
D
M
L
K
D
Q
K
K
Q
L
E
Y
L
Q
K
S
L
QEGENH--FPEE---------DK-----F-G
Y
Q
A
T
-------
F
R
D
Y
I
S
QAGSLR----------ASTSQQNETIASQNAA-A
S
Q
T
Q
A
E
I
G
N
L
I
S
Q
T
E
-
A
K
--
I
---
R
---
D
Y
-
Q
T
A
K
S
A
I
--ETGTSLA
G
Q
N
L
A
Y
S
L
Y
Q
S
Y
K
SQGEEN
P
Q
T
K
-----
V
-
Q
A
V
A
Q
V
E
--------------
A
Q
I
S
Q
L
E
S
S
L
A
T
Y
R
V
Q
YA-----------GSG
T
Q
Q
A
Y
A
S
G
L
----------------------------
S
S
Q
L
E
S
L
K
---------
S
Q
H
L
A
K
V
-----
G
Q
E
L
S
L
L
-----------
A
Q
K
I
L
E
AESGK--KVQGNLLD--KGKITASED
G
------------------
V
L
H
LNPETS-DSS
M
V
A
E
G
T
---
L
--
L
A
Q
L
Y
P
S
L
EREGK
A
K
L
T
A
Y
---------LSSK
D
V
A
R
I
KV----GD---------
S
V
R
--
Y
T
TTHDAG
N
Q
L
F
LD--STITSIDATATKTEKG
N
---
F
F
K
I
E
AETNL
T
S
E
Q
A
E
K
L
R
Y-GVE
G
R
L
Q
M
----------IT---G
K
K
S
Y
L
R
Y
Y
L
D
Q
F
LNKE--
36
Fugue
67.17
17%
-70
- C8 -
-
4TKO
2
?
B:
[3-349]
----------------------
H
R
--
I
E
Y
A
I
T
N
A
V
F
V
-------------
K
A
--------------------------------
D
E
L
S
Y
----
L
S
F
R
V
S
----------------------
G
K
V
I
E
V
Y
K
D
L
G
D
Y
V
K
R
G
--
E
A
L
----------
A
K
L
D
P
T
Y
Y
E
L
E
K
R
T
L
E
K
K
-----------------
M
--
S
A
L
L
E
K
K
K
A
L
E
I
K
I
Q
K
L
E
K
G
-------------------------------------------------
L
H
----------
I
S
L
S
A
K
K
L
K
V
E
S
L
K
K
K
-
R
E
A
L
R
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K
L
L
Q
V
E
E
K
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K
-
L
V
--
K
---
L
---
D
W
-
E
R
Y
K
S
L
F
--
Q
K
G
L
----------
I
P
R
R
K
F
E
E
V
D
T
N
L
K
V
L
-----
L
-
H
E
R
E
Y
L
E
--------------
K
S
I
Q
E
I
N
T
E
I
K
R
A
K
K
G
I
E
-----------
N
A
R
N
E
F
K
T
I
E
E
L
----------------------------
K
K
E
L
S
S
L
E
----------------------
E
E
I
K
S
L
-----------
K
E
R
I
K
T
A
E
Q
K
I
--
K
---------
D
T
V
L
I
A
P
F
D
G
------------------
V
V
A
K
R
F
I
S
R
-
G
D
V
V
R
A
G
Q
P
---
A
--
F
A
L
V
-----
N
P
E
S
F
Y
V
E
V
L
---------
L
E
E
T
K
L
K
G
V
K
V
----
G
N
---------
K
A
Y
--
V
R
L
--
D
A
Y
P
D
I
L
F
E
--
G
V
V
E
E
I
S
P
V
Q
------------
R
I
P
V
K
I
K
I
T
K
G
D
L
S
L
L
R
V
-
G
M
G
G
E
V
E
I
----------
R
R
---
T
------------------
13
HHSearch
67.09
14%
-78
- C8 -
-
4TKO
2
?
B:
[3-349]
-----------------------------------------------------------------------------------
H
R
I
E
Y
A
----
I
T
N
A
V
F
V
K
A
D
-
E
L
S
Y
-------
L
S
F
R
V
S
G
K
V
I
E
V
Y
K
D
L
G
D
Y
V
K
R
G
--
E
A
L
----------
A
K
L
D
P
T
Y
Y
E
L
E
K
R
T
L
E
K
K
-----------------
M
--
S
A
L
L
E
K
K
K
A
L
E
I
K
I
Q
K
L
E
K
G
L
H
I
--
S
----------------------------------------
L
S
A
-----------------
K
K
L
K
V
E
S
L
K
K
K
-
R
E
A
L
R
E
K
L
L
Q
V
E
E
K
I
K
-
L
V
--
K
---
L
---
D
W
-
E
R
Y
K
S
L
F
--
Q
K
G
L
I
P
R
-----------------
R
K
F
E
E
V
-----
D
-
T
N
L
K
V
L
L
--------------
H
E
R
E
Y
L
E
K
S
I
Q
E
I
N
T
E
I
K
-----------
R
A
K
K
G
I
E
---
N
A
----------------------------
R
N
E
F
--------------
K
T
I
E
E
L
-----
K
K
E
L
S
S
L
-----------
E
E
E
I
K
S
L
K
E
R
I
--
K
T
A
E
Q
K
I
K
--
D
T
V
L
I
A
P
F
D
G
------------------
V
V
A
K
R
F
-
I
S
-
R
G
D
V
V
R
A
G
Q
---
P
--
A
F
A
L
V
N
P
----
E
S
F
Y
V
E
V
L
---------
L
E
E
T
K
L
K
G
V
K
V
----
G
N
---------
K
A
Y
--
V
R
L
D
A
Y
P
D
--
I
L
F
E
--
G
V
V
E
E
I
S
P
-------
V
Q
---
R
I
P
V
K
I
K
I
T
K
G
--
D
L
S
L
L
R
V
-
G
M
G
G
E
V
E
I
----------
R
R
---
T
------------------
37
Fugue
63.36
16%
39
- C3 -
-
5IWZ
-
SYCP2_MOUSE
A:
[4-397]
------M
P
V
R
P
D
--
L
Q
Q
L
E
K
C
I
D
D
--
A
L
R
K
N
D
F
K
P
L
L
-------------
A
L
L
Q
I
D
-------
I
CED
V
K
I
K
C
S
KQ
F
L
R
K
L
D
D
L
I
C
R
E
L
N
----
K
K
D
I
Q
T
V
--
S
S
I
L
I
S
-------
I
G
R
C
S
K
N
I
F
I
L
G
Q
A
G
L
Q
T
M
I
K
Q
G
L
V
Q
K
M
----------
V
S
W
F
E
N
S
K
E
I
I
L
N
Q
D
E
A
V
-----------------
M
--
N
M
I
E
D
L
F
D
L
L
M
V
I
Y
D
I
S
D
E
G
K
N
Q
--
V
L
E
S
---------
F
I
-----
P
-
Q
I
C
A
L
-------
V
I
D
S
-------
R
----------
V
N
F
C
I
Q
Q
E
A
L
K
K
M
N
L
M
-
L
D
R
I
N
Q
E
M
L
T
L
M
S
N
M
G
-
E
R
--
I
---
L
DVG
D
Y
-
E
L
Q
V
G
I
V
--
E
A
L
C
R
M
T
T
E
K
R
R
Q
E
L
A
Y
E
W
---------------------------------------------------
F
S
M
D
F
I
-----------
A
N
A
F
K
E
I
K
D
C
E
F
----------------------------
E
T
D
C
R
I
F
L
---------
N
L
V
N
G
I
L
-----
G
D
K
R
R
V
Y
-----------
T
F
P
C
L
S
A
F
L
G
K
--
Y
E
----
L
Q
--
I
P
S
D
E
K
L
E
E
F
------------------
W
I
D
F
N
L
G
S
H
------------------------------
T
L
S
F
Y
---------
I
E
A
V
T
V
P
E
E
K
-----------------
V
Q
--
M
Y
N
I
E
V
R
E
S
K
K
L
L
T
--
L
T
L
K
N
I
V
K
I
S
K
K
E
G
K
E
L
---
L
F
Y
F
D
-
E
S
L
E
I
T
N
V
T
K
K
V
F
G
-
G
L
E
H
H
-------------------------------------
39
Fugue
61.57
20%
58
- C1 -
-
4MTK
-
?
A:
[5-640]
R
L
V
Q
V
D
C
P
L
G
P
D
VL
L
L
Q
R
M
E
G
R
E
E
L
G
R
L
F
A
Y
E
L
H
L
V
S
ENPNLPLEQLLG
K
P
M
S
L
S
L
E
L
PGG
S
R
R
-----------
F
F
H
G
I
V
A
R
C
S
Q
V
A
G
H
G
Q
F
A
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Y
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L
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Q
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Q
V
F
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N
L
G
F
S
D
F
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--
D
A
L
T
R
P
Y
R
E
W
EYC
V
Q
Y
R
E
T
S
F
D
F
I
S
R
L
M
E
Q
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G
I
Y
Y
W
F
R
H
E
QK
R
H
I
L
V
L
S
--
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A
Y
G
A
H
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S
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G
G
Y
A
S
V
P
Y
Y
P
P
T
L
G
--
H
R
E
R
---------
D
H
-----
F
-
F
D
W
Q
M
-------
A
R
E
V
--
Q
P
G
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L
T
L
N
D
Y
D
FQRPG
A
R
L
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R
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I
A
R
P
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D
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---
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---
N
R
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I
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A
I
Q
A
Q
--
H
E
R
V
R
L
R
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V
V
R
G
I
G
A
G
H
L
F
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L
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G
Y
P
R
D
D
Q
N
R
E
Y
L
V
V
-
G
A
E
Y
R
V
V
--------------
Q
E
L
S
Q
F
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S
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L
D
C
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D
A
S
Q
S
F
R
L
L
PQT
P
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V
V
V
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I
W
T
D
QYG
R
V
K
V
H
F
HWDRHDQSNEN
S
S
C
W
I
R
V
S
Q
AWAGKNW
G
S
M
Q
I
P
R
I
-----
G
Q
E
V
I
V
S
F
L
EGDPD
R
P
I
I
T
G
R
V
Y
N
A
E
Q
T
V
PY
E
L
P
A
N
A
T
Q
--
S
G
M
K
S
R
S
S
K
G
GTPA
N
F
N
E
I
R
M
E
DKKGA
E
Q
L
Y
I
H
A
E
R
N
-
Q
D
N
L
V
E
N
D
A
---
S
--
L
S
V
G
H
D
R
N
K
S
I
G
H
D
E
L
A
R
I
G
N
N
R
T
R
A
V
K
L
N
D
T
L
L
V
G
G
A
K
----
S
D
---------
S
V
T
--
G
T
Y
L
I
E
A
G
A
Q
I
R
L
V
C
G
K
S
V
V
E
F
N
A
D
G
T
I
N
I
S
G
S
---
A
F
N
L
Y
A
S
G
N
G
N
I
D
T
G
G
R
L
D
L
-
N
S
G
G
A
S
E
V
----------
D
A
KGK
G
V
Q
G
T
I
D
G
Q
V
Q
A
M
F
P
P
P
--
14
HHSearch
60.67
16%
13
- C8 -
-
5NIK
-
?
G:
[47-302]
--------------------------------------------------------------------------------------
Q
Q
S
----
V
L
A
T
G
K
L
D
A
L
R
-
K
V
D
-------
V
G
A
Q
V
S
G
Q
L
K
T
L
S
V
A
I
G
D
K
V
K
K
D
--
Q
L
L
----------
G
V
I
D
P
E
Q
A
E
N
Q
I
K
E
V
E
A
T
-----------------
L
--
M
E
L
R
A
Q
R
Q
Q
A
E
A
---------------------------------------------------------------------------------------------------
E
L
K
-
L
A
--
R
---
V
---
T
Y
-
S
R
Q
Q
R
L
A
--
Q
T
Q
A
V
S
Q
------------------------------
Q
D
L
D
N
A
A
--------------
T
E
M
A
V
K
Q
--------------------------------------------------------------------------------------------
A
Q
I
G
T
I
-----------
D
A
Q
I
K
R
N
Q
A
S
L
--
D
T
A
K
T
N
L
D
--
Y
T
R
I
V
A
P
M
A
G
------------------
E
V
T
Q
I
T
-
T
L
-
Q
G
Q
T
V
I
A
A
Q
QAP
N
--
I
L
T
L
A
D
M
----
S
A
M
L
V
K
A
Q
---------
V
S
E
A
D
V
I
H
L
K
P
----
G
Q
---------
K
A
W
--
F
T
V
L
G
D
Q
L
--
T
R
Y
E
--
G
Q
I
K
D
V
L
P
T
P
E
K
V
N
D
A
I
---
F
Y
Y
A
R
F
E
V
P
N
P
---
N
G
L
L
R
L
-
D
M
T
A
Q
V
H
I
----------
Q
L
---
T
D
-----------------
15
HHSearch
59.80
16%
4
- C8 -
-
3FPP
-
MACA_ECOLI
B:
[43-302]
----------------------------------------------------------------------------------
P
G
D
L
Q
Q
S
----
V
L
A
T
G
K
L
D
A
L
R
-
K
V
D
-------
V
G
A
Q
V
S
G
Q
L
K
T
L
S
V
A
I
G
D
K
V
K
K
D
--
Q
L
L
----------
G
V
I
D
P
E
Q
A
E
N
Q
I
K
E
V
E
A
T
-----------------
L
--
M
E
L
R
A
Q
R
Q
Q
A
E
A
---------------------------------------------------------------------------------------------------
E
L
K
-
L
A
--
R
---
V
---
T
Y
-
S
R
Q
Q
R
L
A
--
Q
T
Q
A
V
S
Q
------------------------------
Q
D
L
D
N
A
A
--------------
T
E
M
A
V
K
Q
--------------------------------------------------------------------------------------------
A
Q
I
G
T
I
-----------
D
A
Q
I
K
R
N
Q
A
S
L
--
D
T
A
K
T
N
L
D
--
Y
T
R
I
V
A
P
M
A
G
------------------
E
V
T
Q
I
T
-
T
L
-
Q
G
Q
T
V
I
A
A
Q
Q
A
P
N
--
I
L
T
L
A
D
M
----
S
A
M
L
V
K
A
Q
---------
V
S
E
A
D
V
I
H
L
K
P
----
G
Q
---------
K
A
W
--
F
T
V
L
G
D
Q
L
--
T
R
Y
E
--
G
Q
I
K
D
V
L
P
T
P
E
K
V
N
D
A
I
---
F
Y
Y
A
R
F
E
V
P
N
P
---
N
G
L
L
R
L
-
D
M
T
A
Q
V
H
I
----------
Q
L
---
T
D
-----------------
42
Fugue
59.60
12%
-44
* C6 *
-
4RP9
8
ULAA_ECOLI
A:
[6-456]
---------------
N
I
F
T
V
F
F
N
Q
--
V
M
T
N
------
A
-------------
P
L
L
L
G
I
-------
V
-----------
T
C
L
G
Y
I
L
L
-
R
K
S
V
S
----
V
I
I
K
G
T
I
K
T
I
I
G
F
M
L
-------
L
Q
A
G
S
G
I
L
T
S
T
F
K
P
V
V
A
K
M
S
E
V
Y
--
G
I
---------------
N
G
A
I
S
D
T
Y
A
S
M
M
A
T
-----------------
I
--
D
R
M
G
D
A
Y
S
W
V
G
Y
A
V
L
L
A
L
A
L
N
I
C
--
Y
V
L
L
---------
R
R
-----
I
T
G
I
R
T
I
MLT
G
H
I
M
F
Q
Q
A
G
L
I
A
V
T
L
F
----------
I
F
G
Y
S
M
W
T
T
I
I
C
T
A
I
L
-
V
S
L
Y
W
G
I
T
S
N
M
M
Y
K
P
T
-
Q
E
--
V
---
T
---
D
G
-
C
G
F
S
I
G
H
QQ
Q
F
A
S
W
I
A
Y
K
V
A
P
F
L
G
K
K
E
E
S
V
E
D
L
K
L
P
G
W
L
-----
N
-
I
F
H
D
N
I
V
--------------
S
T
A
I
V
M
T
I
F
F
G
A
I
L
L
S
F
------------
G
I
D
T
V
Q
A
M
A
G
K
V
----------------------------
H
W
T
V
Y
I
L
Q
---------
T
G
F
S
F
A
V
-----
A
I
F
I
I
T
Q
-----------
G
V
R
M
F
V
A
E
L
S
E
--
A
F
N
G
I
S
Q
R
LI
P
G
A
V
L
A
I
D
C
A
------------------
A
I
Y
S
F
A
P
N
A
-
V
V
W
G
F
M
W
G
T
---
I
--
G
Q
L
I
A
V
G
I
L
V
A
C
G
S
S
I
L
I
I
P
G
-------
F
I
P
M
F
F
S
N
A
T
I
----
G
V
---------
F
A
N
--
H
F
G
G
W
R
A
A
L
K
I
C
L
V
--
M
G
M
I
E
I
F
G
C
V
W
A
V
K
L
T
G
MSA
W
M
G
M
A
D
W
S
I
L
A
P
P
M
M
Q
G
F
F
S
I
G
I
A
F
M
A
V
I
----------
I
V
---
I
A
L
A
Y
M
F
F
A
G
R
A
L
R
A
E
E
D
A
35
Fugue
56.45
16%
75
- C8 -
-
3FPP
-
MACA_ECOLI
A:
[43-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
D
-
L
Q
Q
S
V
L
A
T
G
K
L
D
A
L
R
K
-
V
D
--
V
G
A
Q
V
---
S
G
-
Q
L
K
T
L
S
V
--
A
I
G
D
K
V
K
K
D
Q
L
L
G
V
I
D
---
P
E
Q
A
E
N
Q
I
K
E
V
-----
E
-
A
T
L
M
E
L
R
--------------
A
Q
R
Q
Q
A
E
A
E
L
K
L
A
R
V
T
Y
S
-----------
R
Q
Q
R
L
A
Q
-
T
Q
A
V
----------------------------
S
Q
Q
D
L
D
N
A
---------
A
T
E
M
A
V
K
-----
Q
A
Q
I
G
T
I
-----------
D
A
Q
I
K
R
N
Q
A
S
L
--
D
T
A
K
T
N
L
D
--
Y
T
R
I
V
A
P
M
A
G
------------------
E
V
T
Q
I
T
T
L
Q
-
G
Q
T
V
I
A
A
Q
Q
-------
A
P
N
I
L
T
L
A
D
M
S
A
M
L
V
K
A
Q
---------
V
S
E
A
D
V
I
H
L
K
P
----
G
Q
---------
K
A
W
--
F
T
V
L
G
D
Q
L
T
R
Y
--
E
--
G
Q
I
K
D
V
L
P
T
P
E
K
V
N
D
A
I
---
F
Y
Y
A
R
F
E
V
P
N
P
N
G
---
L
L
R
L
-
D
M
T
A
Q
V
H
I
----------
Q
L
---
T
D
V
K
N
V
L
T
-----------
16
HHSearch
55.52
16%
-17
- C8 -
-
2F1M
-
ACRA_ECOLI
D:
[54-297]
---------------------------------------------------------------------------------------------
T
E
L
P
G
R
T
S
A
Y
R
-
I
A
E
-------
V
R
P
Q
V
S
G
I
I
L
K
R
N
F
K
E
G
S
D
I
E
A
G
--
V
S
L
----------
Y
Q
I
D
P
A
T
Y
Q
A
T
Y
D
S
A
K
G
D
-----------------
L
--
A
K
A
Q
A
A
A
N
-----------------------------------------------------------------------------------------------------------
I
A
--
Q
---
L
---
T
V
-
N
R
Y
Q
K
L
L
--
G
T
Q
Y
I
S
K
------------------------------
Q
E
Y
D
Q
A
L
--------------
A
D
A
Q
---------------------------------------------------------------------------------------------------
Q
A
-----------
N
A
A
V
T
A
A
K
A
A
V
--
E
T
A
R
I
N
L
A
--
Y
T
K
V
T
S
P
I
S
G
------------------
R
I
G
K
S
N
-
V
T
-
E
G
A
L
V
Q
N
G
Q
AT-
A
--
L
A
T
V
Q
Q
L
----
D
P
I
Y
V
D
V
T
---------
Q
S
--------------
G
---------
K
A
K
--
V
S
L
I
T
S
D
G
I
K
F
P
Q
D
--
G
T
L
E
F
S
D
V
T
V
D
Q
T
--
T
G
---
S
I
T
L
R
A
I
F
P
N
P
---
D
H
T
M
M
P
-
G
M
F
V
R
A
R
L
----------------------------------
44
Fugue
54.51
15%
-74
- C6 -
-
5DOQ
1
?
B:
[1-330]
-------------------------------
M
T
L
E
V
I
-------------
G
I
S
V
L
W
-------
L
-----------
F
L
F
G
Y
I
I
V
A
S
I
D
F
G
----
A
G
F
F
S
V
Y
S
H
W
----
A
-------
N
Q
Q
H
I
L
H
R
I
I
Q
R
Y
L
S
P
V
W
E
V
T
N
V
--
F
L
V
----------
F
F
F
V
G
I
V
G
F
F
P
K
T
A
Y
Y
Y
G
-----------------
S
--
I
L
L
V
P
A
S
I
A
I
V
L
L
A
I
R
G
S
Y
Y
A
F
H
--
T
----------------------
Y
G
E
T
-------
E
R
N
W
Y
L
L
A
Y
G
L
T
----------
G
L
F
I
P
A
S
L
S
I
V
L
T
I
S
E
-
G
G
F
V
E
E
N
A
A
G
-
V
A
L
D
Y
-
G
K
--
L
---
F
---
A
S
-
P
L
S
W
S
V
V
--
L
L
S
V
T
S
V
L
Y
I
S
A
V
F
L
T
Y
Y
A
D
A
A
G
D
E
Q
A
R
A
L
-----
L
-
R
R
Y
A
L
L
W
--------------
S
G
P
T
M
L
S
A
L
L
I
I
Y
Q
L
R
Y
H
----------------------------------------------------------
N
---------
P
E
H
Y
D
N
L
-----
W
N
V
A
W
M
L
-----------
V
I
S
F
L
F
F
V
I
T
V
--
W
L
L
G
R
-----------------------------------------
Q
-
R
R
F
G
W
A
F
I
A
---
L
--
L
F
Q
Y
A
F
A
F
Y
A
Y
G
I
S
H
Y
P
Y
L
---------
L
--------------------------
Y
P
--
Y
L
T
I
Y
D
G
F
T
-------------------------------------
N
E
T
M
A
M
A
L
I
V
-
A
F
I
A
G
L
L
L
----------
L
I
---
P
S
L
Y
L
L
M
R
L
---
F
L
F
N
K
--
21
HHSearch
54.47
15%
-2
- C8 -
-
1VF7
-
MEXA_PSEAE
J:
[26-260]
--------------------------------------------------------------------------------------
T
L
N
----
T
E
L
P
G
R
T
N
A
F
-
R
I
A
E
-------
V
R
P
Q
V
N
G
I
I
L
K
R
L
F
K
E
G
S
D
V
K
A
G
--
Q
Q
L
----------
Y
Q
I
D
P
A
T
Y
E
A
D
Y
Q
S
A
Q
A
N
-----------------
L
--
A
S
T
Q
E
--------------------------------------------------------------------------------------------------------------------------
Q
A
-
Q
R
Y
K
L
L
V
--
A
D
Q
A
V
S
K
------------------------------
Q
Q
Y
A
D
------------------------------------------------------------------------------------------------------------------------
A
-----------
N
A
A
Y
L
Q
S
K
A
A
V
--
E
Q
A
R
I
N
L
R
--
Y
T
K
V
L
S
P
I
S
G
------------------
R
I
G
R
S
A
-
V
T
-
E
G
A
L
V
T
N
G
Q
---
A
NA
M
A
T
V
Q
Q
L
----
D
P
I
Y
V
D
V
T
---------
Q
P
S
T
A
L
L
R
L
R
R
ELAS
G
Q
LERAGDNAA
K
V
S
--
L
K
L
E
D
G
S
Q
--
Y
P
L
E
--
G
R
L
E
F
S
E
V
S
V
D
E
G
--
T
G
---
S
V
T
I
R
A
V
F
P
N
P
---
N
N
E
L
L
P
-
G
M
F
V
H
A
Q
L
----------
Q
-----------------------
28
HHSearch
53.48
16%
-112
* C8 *
-
4KKS
-
?
A:
[94-209]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
V
R
A
P
I
S
G
------------------
Y
I
L
N
I
T
-
K
K
-
I
G
E
T
V
N
P
Q
S
---
N
--
I
A
V
V
G
R
I
----
D
T
K
Q
I
L
T
Y
---------
V
S
E
K
Y
I
S
N
I
K
V
----
G
N
---------
D
A
I
--
I
E
V
G
A
Y
S
N
--
E
K
F
K
--
A
K
V
S
E
I
S
P
I
L
D
S
K
S
--
R
---
T
I
E
V
Y
L
T
P
I
G
S
--
N
L
D
K
L
I
I
-
G
M
F
S
K
I
K
L
----------
I
T
---
K
R
-----------------
38
Fugue
50.19
20%
28
- C2 -
-
4KRT
2
?
A:
[7-353]
--------
H
H
H
H
--
H
M
Q
S
--------
R
N
N
N
N
L
K
G
I
D
V
--------------------------------------------------------------------------------
S
N
W
K
G
N
I
N
F
E
S
V
K
N
D
--------
G
V
E
----------
V
V
Y
I
K
A
T
E
G
-----------------------------
N
Y
F
K
D
K
-----
Y
A
K
Q
N
Y
E
G
A
K
E
Q
--
G
L
------------
S
-----
V
-
G
F
Y
H
F
-------
F
R
-------
A
N
K
----------
G
A
K
D
Q
A
N
F
F
I
D
Y
L
N
E
I
G
A
V
N
Y
D
C
K
L
A
L
D
I
E
T
T
E
G
V
G
--
V
---
R
---
D
L
T
S
M
C
I
E
F
L
--
E
E
V
K
R
L
T
G
K
E
V
V
V
Y
T
Y
T
S
F
A
N
N
N
----------------------------------------
L
D
S
R
L
G
N
Y
P
V
W
I
A
-----------
H
Y
G
V
N
T
P
G
A
N
N
I
----------------------------
W
S
S
W
V
G
F
Q
---------
Y
S
E
N
G
S
V
A
GVN
G
G
C
D
M
N
E
F
-----------
T
E
E
I
F
I
D
S
S
--------
N
F
N
L
--
D
N
A
T
T
K
N
V
S
T
------------------
K
L
N
I
R
A
K
G
T
-
T
N
S
--------------------------
K
I
I
G
S
---------
I
P
A
G
E
T
F
K
I
K
W
----
V
D
---------
E
D
Y
LG
W
Y
Y
V
E
Y
N
G
V
V
G
Y
V
N
--
A
D
Y
V
E
K
L
Q
M
A
T
T
Y
N
V
S
T
---
F
L
N
V
R
E
E
G
S
L
N
S
R
I
V
D
K
I
N
S
-
G
D
I
F
R
I
D
W
VDSDFIGWYR
I
T
---
T
K
N
G
K
V
G
F
V
N
A
E
F
V
K
K
L
--
27
HHSearch
47.75
16%
-91
- C- -
-
4KKU
-
?
A:
[115-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
V
R
A
P
I
S
G
------------------
Y
I
L
N
I
T
-
K
K
-
I
G
E
T
V
N
P
Q
S
---
N
--
I
A
V
V
G
R
I
----
D
T
K
Q
I
L
T
Y
---------
V
S
E
K
Y
I
S
N
I
K
V
----
G
N
---------
D
A
I
--
I
E
V
G
A
Y
S
N
--
E
K
F
K
--
A
K
V
S
E
I
S
P
I
L
D
S
K
S
--
R
---
T
I
E
V
Y
L
T
P
I
G
S
--
N
L
D
K
L
I
I
-
G
-
F
S
K
I
K
L
----------
I
T
---
K
R
-----------------
26
HHSearch
47.37
15%
-116
- C8 -
-
3T53
-
CUSB_ECOLI
C:
[127-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
T
--
R
F
T
L
K
A
P
I
D
G
------------------
V
I
T
A
F
D
-
L
R
-
A
G
M
N
I
A
K
D
N
---
V
--
V
A
K
I
Q
G
M
----
D
P
V
W
V
T
A
A
---------
I
P
E
S
I
A
W
L
V
K
D
----
A
S
---------
Q
F
T
--
L
T
V
P
A
R
P
D
--
K
T
L
T
--
I
R
K
W
T
L
L
P
G
V
D
A
A
--
T
R
---
T
L
Q
L
R
L
E
V
D
N
A
---
D
E
A
L
K
P
-
G
M
N
A
W
L
Q
L
----------
N
T
---
A
S
-----------------
24
HHSearch
46.57
12%
28
- C8 -
-
5C22
-
HLYDC_ECOLX
B:
[3-268]
---------------------------------------------------------------------------------------------------------
S
K
E
-------
I
K
P
I
E
N
S
I
V
K
E
I
I
V
K
E
G
E
S
V
R
K
G
--
D
V
L
----------
L
K
L
T
A
L
G
A
E
A
D
--
T
L
K
T
Q
-----------------
S
--
S
L
L
Q
T
R
L
E
Q
T
R
Y
Q
I
L
S
R
S
I
E
L
N
K
LP
E
L
K
L
PDEPYFQNV
S
E
-----
E
-
E
V
L
R
L
-------
T
S
L
I
K
E
Q
F
S
T
W
Q
----------
N
Q
K
Y
Q
K
E
L
N
L
D
K
K
R
A
E
-
R
L
T
I
L
A
R
I
N
R
Y
E
N
L
S
R
-
V
E
--
K
---
S
---
R
L
-
D
D
F
R
S
L
L
--
H
K
Q
A
I
A
K
-----------------
H
A
V
L
E
Q
-----
E
-
N
K
Y
V
E
A
A
--------------
N
E
L
R
V
Y
K
S
Q
L
E
Q
I
E
S
E
I
L
-----------
S
A
K
--------------------------------------
E
E
Y
Q
L
V
T
---------
R
L
F
K
N
E
I
-----
L
D
K
L
R
Q
T
-----------
T
D
N
I
E
L
L
T
L
E
L
--
E
K
N
E
E
R
Q
Q
--
A
S
V
I
R
A
P
V
S
G
------------------
K
V
Q
Q
L
K
-
V
H
T
E
G
G
V
V
T
T
A
E
---
T
--
L
M
V
I
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
45.12
21%
87
- C8 -
-
3VKG
-
?
A:
[1907-2227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
N
E
K
R
D
Q
L
E
E
E
Q
L
H
L
N
I
G
-----------------------------
L
K
K
-------
L
R
D
T
E
A
Q
V
K
D
L
Q
----------
V
S
L
A
Q
K
N
R
E
L
D
V
K
N
E
Q
-
A
N
Q
K
L
K
Q
M
--
V
Q
D
Q
Q
A
-
A
E
--
I
---
K
------
Q
K
D
A
R
E
L
--
Q
V
Q
L
D
V
R
N
K
E
I
A
V
Q
K
V
K
A
Y
A
D
L
-------
P
-----
L
R
E
E
V
E
Q
L
E
N
A
A
N
E
L
K
L
K
Q
D
E
I
V
A
T
I
T
A
L
E
K
S
I
A
T
Y
K
E
E
Y
A
-----------
T
L
I
R
E
-----------------------------------
T
E
Q
I
K
T
E
S
---------
S
K
V
K
N
K
V
-----
D
R
S
I
A
L
L
-----------
D
N
--
L
N
S
E
R
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
42.68
17%
-113
- C8 -
-
2EJM
-
A:
[2-47]
---------------------------------------------------------------------------------------------
S
S
G
S
S
G
V
S
S
Q
E
T
Q
G
G
-------
P
L
A
P
M
T
G
T
I
E
K
V
F
V
K
A
G
D
K
V
K
A
G
--
D
S
L
----------
M
V
M
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
41.56
21%
-120
- C8 -
-
2K7V
-
B:
[45-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
P
F
A
G
------------------
V
V
K
E
L
K
-
V
N
-
V
G
D
K
V
K
T
G
S
---
L
--
I
M
I
F
E
V
E
----
G
A
A
P
A
A
A
P
---------
A
K
--------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
38.64
27%
53
- C7 -
-
4FZ4
-
?
A:
[33-129]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
Y
S
Y
Q
K
A
-----------------
L
W
E
E
F
L
R
I
G
K
D
N
M
D
Y
A
S
K
--
M
K
A
D
D
K
--
F
F
H
K
---------
V
K
G
D
L
N
D
F
-
K
Y
Q
I
K
-------
V
E
N
Y
I
R
Q
V
A
E
L
R
----------
K
K
Y
P
G
D
N
T
I
E
E
E
Y
N
A
H
-
L
K
Q
D
E
G
K
--
S
I
A
S
Q
E
G
-
A
T
--
L
---
R
---
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------