@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0046: (2017-12-14 )
MMDKRIFVEKKADFQVKSESLVRELQHNLGLSSLKSIRIVQVYDVFDLAEDLFAPAEKHIFSEQGTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQEALLLLGSSSDVTVNTAQLYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFSESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMATIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDTFVAECNKENIDAVVVATVTEKPNLVMHWNGETIVDLERRFLDINGVRVVVDAKVVDKDVKLPEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEASVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEATARLVAAGANWSKARFSYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLVAFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEASQADHKVTSASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGGFVFTSPEEIAGVEKIGQTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKEKVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDKTNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVKSGLLPYGNFEDANNTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVSHGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQIIGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK
Atome Classification :
(20 SA)
---.........10....-....20........----30....--....40..---....--..50........60........70........80........90.........100.......110.......120.......130.......140------.......150.......160.......170.......180..-.....190.......200...-....210.......220.......230....----...240.......250.......260.......270.......280.--......290.......300.......310.......320.......330.......340......---------.--------350.-..---..--------..360.......370.......380......-----.390.......400.--......410.......420..----.....430.-..------------....440---...-----....450........460.......470....--...480.......490---........500.......510.......520----.----......530.......540....-...550.......560.......570.......580....------....590.--......600.......610.......620.------......630.......640...-..----..650..-.....660.......670.......680.......690-....-.....700...--....--710----........720.......730----------.......740...-....750..-.....760.......770..-.....780....--------...790--.......--800.......--810....----------------.---..820--......---...----830------.------.----------.------------------.----------.---..840..-------.--------.-------.-...850..-.-------....860-........870.......-880.---....-----..--------------------890-------------------------------------.-------------------------------------..--..----------....900.......--------------910----.-------------......920......--.---..930.........940.......950........960..----------.....970------.......980....--------...990.......1000......1010....--..1020......1030......1040......1050......1060......1070-......-1080........-1090--.......1100......1110......1120......1130......1140......1150.....-.1160......1170......1180......1190......1200......1210......1220......1230......1240
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MMD
K
R
I
F
V
EKKAD
F
Q
-V
K
S
E
S
L
V
R
E
L
Q
H
NL----GL
S
S
L
K
--
S
I
R
I
V
Q
V
Y
---
D
V
F
D
--
L
A
E
D
L
FA
P
A
E
K
H
I
FSEQGT
D
H
V
L
D
E
V
S
V
Q
A
D
L
A
N
Y
A
F
F
A
I
E
SL-PG
Q
F
D
Q
R
AASSQ
E
A
L
L
L
LGSSS
D
V
T
V
N
T
A
Q
L
Y
L
V
NKDI
D
A
T
E
L
E
A
V
K
N
Y
LLN------P
V
D
S
R
F
K
D
I
T
T
G
I
A
K
Q
E
FSESDKTI
P
K
L
T
F
F
E
SY
T
A
E
D
F
A
R
Y
-
K
A
EQGMAME
V
D
D
L
L
F
I
Q
D
Y
F
K
-
S
IGRVPTET
E
L
K
V
L
D
T
Y
W
SDHCRHT
T
F
E
T
E
L
----
K
HIDF
S
A
S
K
F
Q
K
Q
L
Q
S
T
Y
D
K
Y
I
A
M
R
E
ELGRSEK
P
Q
T
L
M
D
M
A
T
I
F
G
R
Y
--ERANGRLDDMEVSDEIN
A
C
S
V
E
I
E
V
DVDGVKE
P
W
L
L
M
F
KNETHNHPTEIEPFG
G
A
A
T
C
I
G
G
A
IRD---------P--------LS
G
R
-
S
Y
---
V
Y
--------
Q
A
M
RISGAGDITAPISETRAGKL
P
Q
Q
V
I
S
K
T
-----
A
AHG
Y
S
SYGNQI
G
L
A
--
T
T
Y
V
R
E
YFH
P
G
F
V
A
K
R
M
EL
G
A
----
V
VGAAPKGN-VV------------REKPEAG---
D
V
I
-----
I
L
LGGK-TGRDGVGGATGSS
K
V
Q
T
V
E
S
V
E
TAG--AEVQKGN
A
I
E
E
R
K
I
Q
----
R
L
F
RNGN
V
T
R
L
I
KKSNDFGAG
G
V
C
V
A
I
G
E
LA----D----G
L
E
I
DLNKV
P
L
K
Y
QGLNG
T
E
I
A
I-SESQ
E
R
M
A
V
V
VRPE
D
V
D
T
F
V
A
ECNKENI
D
A
V
V
V
A
-
T
VTEK------P
N
L
V
M
H
WN--G
E
T
I
V
D
L
E
R
R
FLDIN
G
V
R
V
V
V
D
A
K
VVDKDV------KL
P
E
E
RQT
S
A
E
TLES
D
T
L
T
V
L
S
-
D
L
----
N
H
A
S
Q
K
G
-
L
Q
T
I
F
DCSVGRSTVNHPLGG
R
Y
Q
LTPTEA
S
V
Q
KL
P
V
---QHGV-
T
H
T
A
S
V
I
A
QGF--NPYV--AE-----WSPYH
G
A
A
Y
A
V
I
E
A
T
A
R
L
V
AA----------GANW
S
K
ARF
S
Y
Q
E
-
Y
F
E
R
M
D
K
Q
A
-
E
RFG
Q
P
V
A
A
L
L
G
S
I
E
A
Q
I
Q
L-GLPSIGGKDSMS--------G
T
F
E
EL--TVPP
T
L
V
--
A
F
GVTTADSR--KVL
S
P
E
F
----------------
K
---
A
VG----E
N
I
Y
Y
I---PGQ----ALS------A------E----------I------------------
D
----------
F
---
D
L
I
-
K
K
N
-------
F
--------
A
-------
Q
-FEASQADH-K-------VTSASA--VKYG
G
V
V
E
S
L
A
L
A
T
F
GNY-IGA
E
---
V
T
L
P
-----
E
L
--------------------
K
---------------------------------------
T
-------------------------------------
A
L
--
T
A
----------QLG
G
F
V
FT
S
P
E
E
I
A
--------------
G
V
E
----
K
-------------IGQTKA
D
--
F
T
L
T
V
N
--
G
---
V
K
L--D
G
H
KL
D
S
A
F
Q
G
T
L
E
EVYPTEF-
T
Q
A
K
E
L
E
EVPAV
A
----------
S
D
V
V
I
K
A
K
------EKVEK
P
V
V
Y
I
PVFP--------GTNSEYD
S
A
K
A
F
E
KEGA
E
V
N
L
V
P
F
V
T
L
N
E
E
A
--
I
V
K
S
V
E
T
M
V
DNIDKT
N
I
L
F
F
AGGFSAADEPDGSA
K
F
I
V
N
I
LLNE
K
V
R
V
A
I
D
S
F
I
AR-G
G
L
I
I
G
-I--C
N
G
F
Q
A
L
V
K-SGL---LPYGNFEDANNTS
P
T
L
F
YND
A
N
Q
H
V
A
K
M
V
E
T
R
IANTNSP
W
L
A
G
V
Q
VG
D
I
H
A
I
PVSHGE
G
K
F
V
V
T
A
E
-
E
F
A
E
L
RDN
G
Q
I
F
S
Q
Y
VDFNGKPSMDSKYNPNG
S
V
H
A
I
EGITSKN
G
Q
I
I
G
KMGH
S
E
R
Y
EDGLFQNIPGNK
D
Q
H
L
F
A
S
A
V
K
H
FTGK
1
PsiBlast_PDB
72.25
24%
25
- C5 -
-
3UGJ
1
PUR4_SALTY
A:
[187-1271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
-
K
L
G
R
N
P
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
I
F
N
A
D
W
I
I
DG
K
P
Q
P
K
S
L
F
K
M
I
K
N
T
F
E
T
T
P
D
Y
V
-----
L
S
A
Y
K
D
N
A
A
V
M
E
G
S
A
V
-
G
R
Y
F
A
D
H
N
T
G
R
Y
D
F
H
Q
--------------------
E
P
A
H
I
L
M
K
V
E
T
H
N
H
P
T
A
I
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
TGR
G
A
K
P
--------
K
A
G
L
V
G
F
---
S
V
--------
S
N
L
R
I
P
G
---
F
E
Q
P
W
E
E
D
-
F
G
K
-
P
E
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
F
N
N
E
F
G
R
P
AL
T
G
Y
F
R
T
Y
E
E
K
V
N
S
H
N
G
E
E
L
R
G
Y
HK
P
I
M
L
A
G
G
I
G
N
-
I
R
------------
A
D
H
V
Q
K
G
---
E
I
V
VGA
K
L
I
V
L
G
G
P
-
A
M
N
I
G
L
-----------------
D
F
--
A
S
V
Q
R
D
N
P
E
M
E
R
R
C
Q
E
V
I
D
R
C
W
Q
L
G
D
A
N
P
I
L
-
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
----
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
G
M
S
P
L
E
I
W
C
-
N
E
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
E
R
A
P
Y
A
V
I
G
-
D
A
T
E
E
------
Q
H
L
S
L
H
D
N
HF
D
N
Q
P
I
D
L
P
L
D
V
L
L
G
K
T
P
K
M
T
R
D
V
Q
T
----
L
------
K
A
K
G
D
A
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
-
H
L
----
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
T
G
M
V
A
R
D
Q
M
V
G
P
W
Q
V
P
V
A
D
C
A
V
T
T
A
S
L
---
D
----
S
Y
Y
G
E
A
M
S
I
G
E
--
R
A
P
V
--
A
L
-----
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
QIGDIKR
I
K
L
S
A
N
W
M
A
A
A
G
H
P
G
E
-
D
A
G
L
Y
D
A
---------
V
K
A
V
G
E
E
L
C
P
Q
L
G
L
-
T
I
P
V
--
G
K
D
S
M
S
M
K
T
R
W
Q
EG--
Q
R
E
M
--
T
S
P
L
S
L
V
I
S
A
F
-
A
R
V
E
D
V
R
--
H
T
L
T
P
Q
L
STED
N
A
L
L
L
IDLGKGH
N
---
A
L
G
AT
A
L
A
Q
V
Y
R
Q
---
L
G
D
----
K
P
A
------
D
------
V
----------
R
------------------
D
----------
V
---
A
Q
L
-
K
G
F
-------
Y
--------
D
-------
A
-
M
Q
A
L
V
A
A
R
-
K
-------
L
L
A
W
H
D
--
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
-
C
G
V
Q
---
V
D
I
A
ALGDD
H
L
--------------------
A
---------------------------------------
A
-------------------------------------
L
F
--
N
E
----------
E
L
G
G
V
I
Q
V
R
A
E
D
R
D
--------------
A
V
E
----
A
L
L
A
Q
Y
GLADCVHY
L
G
Q
A
L
A
G
D
R
F
V
I
T
A
N
------------
D
Q
T
V
F
S
E
S
R
T
T
L
R
V
W
W
A
E
T
T
-
W
Q
M
Q
R
L
R
D
N
P
Q
C
A
D
Q
E
H
E
A
K
A
ND
T
D
P
G
L
N
V
K
L
SFDIN
E
D
I
A
A
P
Y
I
A
T
G
A
R
P
K
V
A
VLREQ
G
V
N
S
H
V
E
M
A
A
A
F
H
R
A
G
F
D
A
I
D
V
H
M
S
D
L
L
G
G
R
--
I
---------
G
L
G
N
F
H
A
L
V
A
C
G
G
F
S
Y
G
D
V
L
G
A
G
E
G
W
A
K
S
I
L
F
N
H
R
V
R
D
E
F
E
T
F
F
H
R
P
Q
T
L
A
L
G
-
V
--
C
N
G
C
Q
M
M
S
N
L
R
E
L
---
I
P
------
G
S
E
L
W
P
R
F
V
R
N
H
S
D
R
F
E
A
R
F
S
L
V
E
V
T
Q
S
P
S
L
L
L
Q
G
M
-
V
G
S
Q
M
P
I
A
V
S
H
G
E
G
R
V
E
V
R
D
D
A
H
L
A
A
L
E
S
K
G
L
V
A
L
R
Y
V
D
N
F
G
K
V
T
E
T
Y
P
A
N
P
N
G
S
P
N
G
I
T
A
V
T
T
E
N
G
R
V
T
I
M
M
P
H
P
E
R
----------------------------
14
HHSearch
53.09
24%
24
- C5 -
-
2HS3
1
PURL_THEMA
A:
[5-597]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
N
I
L
K
E
K
L
G
R
E
P
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
H
T
K
K
Y
I
----
R
R
L
------------------------------
P
K
T
------------------------
G
F
E
G
-
N
A
G
V
V
N
L
-------
D
D
Y
Y
S
V
A
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
---------
V
--------
L
A
M
G
-
A
R
---
P
T
--------
A
I
F
D
S
L
H
M
--
S
R
---------------
I
I
D
G
-----
I
I
E
G
I
A
D
Y
G
N
S
I
G
V
P
--
T
V
G
G
E
L
R
I
S
S
L
Y
A
H
N
P
L
V
N
V
L
----
A
A
G
V
V
R
N
D
M
L
V
D
------------
S
K
A
S
R
P
G
---
Q
V
I
-----
V
I
F
G
G
A
-
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
L
T
G
D
--
K
A
T
K
--
L
S
I
Q
V
G
D
P
F
A
E
K
M
L
I
----
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
----
G
A
I
V
H
L
D
R
V
P
L
R
E
P
D
M
E
P
W
E
I
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
-
E
V
I
E
E
------
P
V
Y
R
V
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
-
V
E
Y
T
P
G
K
--------
I
---
P
E
F
K
R
-----------
V
-
E
F
----
E
E
V
N
A
R
E
-
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
P
--------
G
F
G
A
A
V
M
R
I
K
R
---------
D
G
G
Y
S
L
V
T
H
S
--
R
A
D
L
--
A
L
-----
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
----------
G
A
E
P
L
A
I
T
--
N
C
V
-
N
Y
G
D
P
D
V
-
D
-
P
V
G
--
L
S
A
M
M
T
A
L
K
N
A
C
E
F
S
-
G
V
P
V
A
S
G
N
A
S
L
Y
--------
N
T
Y
Q
G
K
--
P
I
P
P
T
L
V
--
V
G
M
L
G
K
V
N
P
Q
--
K
V
A
K
-----------------------
P
K
P
----
S
K
V
F
A
V
---
G
W
N
----
D
--------------------------
F
------------------
E
----------
L
---
E
R
E
-
K
E
L
-------
W
--------
R
-------
A
-
I
R
K
L
S
E
E
G
A
F
-------
I
L
S
S
S
Q
--
L
----
L
T
R
T
H
V
E
T
F
R
--
E
-
Y
G
L
K
---
I
E
V
K
-----
L
P
--------------------
E
VRPAHQ
M
V
-------------------------------
L
-------------------------------------
V
F
--
S
E
----------
R
T
P
--
V
V
D
V
P
V
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.79
26%
16
- C5 -
-
3VIU
1
PURL_THET8
A:
[74-647]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
E
G
W
A
V
A
F
K
I
E
S
H
N
H
P
S
A
V
E
P
F
Q
G
A
A
T
G
V
G
G
I
L
R
D
---------
I
--------
M
S
M
G
-
A
R
PI
A
L
L
--------
D
S
L
R
F
-------
G
P
P
E
E
A
R
S
R
Y
L
L
K
G
V
V
S
----------
G
I
A
F
Y
G
N
A
I
G
V
P
--
T
V
G
G
D
L
Y
F
H
E
G
Y
R
E
N
P
L
V
N
A
M
----
C
L
G
L
L
R
E
E
H
-
L
K
------------
R
S
R
A
S
L
G
---
R
P
I
-----
Y
Y
A
G
A
K
-
T
G
R
D
G
I
-------------------------
V
G
D
P
F
L
G
K
L
L
M
----
E
A
T
L
E
A
I
E
L
D
L
V
E
G
V
Q
D
M
G
A
A
G
L
T
S
S
L
S
E
L
A
----
H
K
S
G
L
G
V
E
L
H
L
D
L
V
P
T
R
E
E
G
M
T
P
E
E
L
L
L
-
S
E
S
Q
E
R
M
V
L
V
P
K
E
G
K
E
K
A
L
E
E
V
F
G
R
W
G
L
D
C
V
P
V
A
R
T
I
P
E
R
------
V
F
R
V
L
-
F
R
--
G
E
V
V
A
E
V
P
T
E
A
L
----
A
E
A
P
T
Y
V
R
V
G
R
E
D
P
------
E
V
R
R
L
R
E
T
P
I
P
P
L
E
A
D
P
Q
E
V
L
R
-
R
L
L
A
SP
N
L
A
S
R
E
A
-
V
Y
E
R
Y
D
---------
H
Q
V
G
T
R
T
A
L
L
P
G
K
G
D
A
A
V
L
W
I
---
K
G
T
R
-
L
G
V
A
A
K
V
D
Q
----
N
P
R
Y
--
S
R
-----
L
H
P
R
L
G
A
M
H
A
L
A
E
A
C
R
N
V
S
V
V
----------
G
A
K
----
P
L
A
Y
T
D
-
G
L
N
L
G
S
P
E
T
P
E
G
Y
H
E
L
A
E
T
I
A
G
L
K
E
A
S
E
A
L
-
G
V
P
V
V
S
G
N
V
S
L
Y
--------
N
E
S
G
G
K
--
R
I
P
P
T
A
M
--
V
G
V
V
G
V
L
E
V
D
--
K
R
A
E
M
G
F
----------------
R
---
R
P
G
----
E
V
L
L
L
I
G
EE
R
G
E
----
L
G
A
------
S
------
E
----------
V
------------------
L
----------
Y
---
L
L
T
-
G
K
E
-------
F
G
H
PPRLD
L
G
-------
R
-
E
K
A
V
Q
E
A
I
-
R
D
L
I
Q
R
GL
T
R
T
A
H
D
--
V
A
E
G
G
L
L
L
A
L
A
E
M
T
F
P
Y
G
-
V
G
A
T
---
V
E
V
R
-----
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
49.82
25%
20
- C5 -
-
2HRY
1
PURL_THEMA
A:
[67-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
E
S
A
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
---------
V
--------
L
A
-----------------------
M
G
A
R
P
-
T
A
I
F
D
S
L
H
M
S
R
I
I
D
G
I
I
----------
E
G
I
A
D
Y
G
N
S
I
G
V
P
--
T
-----------
V
G
G
E
L
R
I
S
S
----
L
Y
A
H
N
P
L
V
N
-
V
L
A
A
G
V
V
R
NDMLVD
S
K
A
S
R
P
G
---
Q
V
I
-----
V
I
F
G
G
A
-
T
G
R
D
G
I
-------------------------
V
G
D
P
F
A
E
K
M
L
I
----
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
----
A
K
G
NL
G
A
I
V
H
L
D
R
V
P
L
R
E
P
D
M
E
P
W
E
I
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
-
E
V
I
E
E
------
P
V
Y
R
V
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
----------
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
--
E
V
N
A
R
E
V
F
E
-
Q
Y
----
D
H
--
M
V
G
-
T
D
T
V
V
P
P
G
F
G
A
A
V
M
R
I
K
R
D
G
G
Y
S
L
------------------
V
-
T
H
S
R
A
D
L
A
L
-----------------
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
----------
G
A
E
----
P
L
A
I
T
N
-
C
V
N
Y
G
D
P
D
V
-
D
P
V
G
--
L
S
A
M
M
T
A
L
K
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
Y
--------
N
T
Y
Q
G
K
--
P
I
P
P
T
L
V
--
V
G
M
L
G
K
V
N
P
Q
--
K
V
A
K
P
K
P
----------------
S
K
V
F
A
V
G
----
W
N
------------------------------------------------------------
D
----------
F
---
E
L
E
-
R
E
K
---------------------------
E
L
W
R
A
I
R
-
K
-------
L
S
E
E
G
A
F
I
L
S
S
S
Q
L
L
T
R
T
H
V
E
T
F
R
E
Y
G
L
K
I
E
---
V
K
L
P
-----
E
V
--------------------
R
---------------------------------------
P
-------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.17
25%
21
- C5 -
-
2HS3
1
PURL_THEMA
A:
[67-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
---------
V
--------
L
A
-----------------------
M
G
A
R
P
-
T
A
I
F
D
S
L
H
M
S
R
I
I
D
G
I
I
----------
E
G
I
A
D
Y
G
N
S
I
G
V
P
--
T
-----------
V
G
G
E
L
R
I
S
S
----
L
Y
A
H
N
P
L
V
N
-
V
L
A
A
G
V
V
R
NDMLVD
S
K
A
S
R
P
G
---
Q
V
I
-----
V
I
F
G
G
A
-
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
L
T
G
D
--
K
A
T
K
--
L
S
I
Q
V
G
D
P
F
A
E
K
M
L
I
----
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
----
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
D
M
E
P
W
E
I
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
-
E
V
I
E
E
------
P
V
Y
R
V
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
----------
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
--
E
V
N
A
R
E
V
F
E
-
Q
Y
----
D
H
--
M
V
G
-
T
D
T
V
V
P
P
G
F
G
A
A
V
M
R
I
K
R
D
G
G
Y
S
L
------------------
V
-
T
H
S
R
A
D
L
A
L
-----------------
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
----------
G
A
E
----
P
L
A
I
T
N
-
C
V
N
Y
G
D
P
D
V
-
D
P
V
G
--
L
S
A
M
M
T
A
L
K
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
Y
--------
N
T
Y
Q
G
K
--
P
I
P
P
T
L
V
--
V
G
M
L
G
K
V
N
P
Q
--
K
V
A
K
P
K
P
----------------
S
K
V
F
A
V
G
----
W
N
------------------------------------------------------------
D
----------
F
---
E
L
E
-
R
E
K
---------------------------
E
L
W
R
A
I
R
-
K
-------
L
S
E
E
G
A
F
I
L
S
S
S
Q
L
L
T
R
T
H
V
E
T
F
R
E
Y
G
L
K
I
E
---
V
K
L
P
-----
E
V
--------------------
R
---------------------------------------
P
-------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.15
25%
19
- C5 -
-
2HRU
1
PURL_THEMA
A:
[67-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
E
S
A
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
---------
V
--------
L
A
-----------------------
M
G
A
R
P
-
T
A
I
F
D
S
L
H
M
S
R
I
I
D
G
I
I
----------
E
G
I
A
D
Y
G
N
S
I
G
V
P
--
T
-----------
V
G
G
E
L
R
I
S
S
----
L
Y
A
H
N
P
L
V
N
-
V
L
A
A
G
V
V
R
NDMLVD
S
K
A
S
R
P
G
---
Q
V
I
-----
V
I
F
G
G
A
-
T
G
R
D
G
I
-------------------------
V
G
D
P
F
A
E
K
M
L
I
----
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
----
A
K
G
NL
G
A
I
V
H
L
D
R
V
P
L
R
E
P
D
M
E
P
W
E
I
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
-
E
V
I
E
E
------
P
V
Y
R
V
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
----------
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
--
E
V
N
A
R
E
V
F
E
-
Q
Y
----
D
H
--
M
V
G
-
T
D
T
V
V
P
P
G
F
G
A
A
V
M
R
I
K
R
D
G
G
Y
S
L
------------------
V
-
T
H
S
R
A
D
L
A
L
-----------------
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
----------
G
A
E
----
P
L
A
I
T
N
-
C
V
N
Y
G
D
P
D
V
-
D
P
V
G
--
L
S
A
M
M
T
A
L
K
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
Y
--------
N
T
Y
Q
G
K
--
P
I
P
P
T
L
V
--
V
G
M
L
G
K
V
N
P
Q
--
K
V
A
K
P
K
P
----------------
S
K
V
F
A
V
G
----
W
N
------------------------------------------------------------
D
----------
F
---
E
L
E
-
R
E
K
---------------------------
E
L
W
R
A
I
R
-
K
-------
L
S
E
E
G
A
F
I
L
S
S
S
Q
L
L
T
R
T
H
V
E
T
F
R
E
Y
G
L
K
I
E
---
V
K
L
P
-----
E
V
--------------------
R
---------------------------------------
P
-------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.71
25%
20
- C5 -
-
2HS0
2
PURL_THEMA
A:
[67-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
---------
V
--------
L
A
-----------------------
M
G
A
R
P
-
T
A
I
F
D
S
L
H
M
S
R
I
I
D
G
I
I
----------
E
G
I
A
D
Y
G
N
S
I
G
V
P
--
T
-----------
V
G
G
E
L
R
I
S
S
----
L
Y
A
H
N
P
L
V
N
-
V
L
A
A
G
V
V
R
ND
M
L
V
D
S
K
A
S
R
P
G
---
Q
V
I
-----
V
I
F
G
G
A
-
T
G
R
D
G
I
-----------------------
I
Q
V
G
D
P
F
A
E
K
M
L
I
----
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
----
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
D
M
E
P
W
E
I
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
-
E
V
I
E
E
------
P
V
Y
R
V
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
----------
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
--
E
V
N
A
R
E
V
F
E
-
Q
Y
----
D
-----
G
-
T
D
T
V
V
P
P
G
F
G
A
A
V
M
R
I
K
R
D
G
G
Y
S
L
------------------
V
-
T
H
S
R
A
D
L
A
L
-----------------
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
----------
G
A
E
----
P
L
A
I
T
N
-
C
V
N
Y
G
D
P
D
V
-
D
P
V
G
--
L
S
A
M
M
T
A
L
K
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
Y
--------
N
T
Y
Q
G
K
--
P
I
P
P
T
L
V
--
V
G
M
L
G
K
V
N
P
Q
--
K
V
A
K
P
K
P
----------------
S
K
V
F
A
V
G
----
W
N
------------------------------------------------------------
D
----------
F
---
E
L
E
-
R
E
K
---------------------------
E
L
W
R
A
I
R
-
K
-------
L
S
E
E
G
A
F
I
L
S
S
S
Q
L
L
T
R
T
H
V
E
T
F
R
E
Y
G
L
K
I
E
---
V
K
L
P
-----
E
V
--------------------
R
---------------------------------------
P
-------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.68
25%
20
- C5 -
-
2HS4
2
PURL_THEMA
A:
[67-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
I
E
S
H
N
H
P
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
---------
V
--------
L
A
-----------------------
M
G
A
R
P
-
T
A
I
F
D
S
L
H
M
S
R
I
I
D
G
I
I
----------
E
G
I
A
D
Y
G
N
S
I
G
V
P
--
T
-----------
V
G
G
E
L
R
I
S
S
----
L
Y
A
H
N
P
L
V
N
-
V
L
A
A
G
V
V
R
NDMLVD
S
K
A
S
R
P
G
---
Q
V
I
-----
V
I
F
G
G
A
-
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
L
T
G
D
--
K
A
T
K
--
L
S
I
Q
V
G
D
P
F
A
E
K
M
L
I
----
E
A
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
----
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
D
M
E
P
W
E
I
L
I
-
S
E
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
F
G
D
V
V
A
-
E
V
I
E
E
------
P
V
Y
R
V
M
Y
R
--
N
D
L
V
M
E
V
P
V
Q
L
L
----------
A
N
A
P
E
E
D
I
V
E
Y
T
P
G
K
I
P
E
F
K
R
V
E
F
E
--
E
V
N
A
R
E
V
F
E
-
Q
Y
----
D
H
--
M
V
G
-
T
D
T
V
V
P
P
G
F
G
A
A
V
M
R
I
K
R
D
G
G
Y
S
L
------------------
V
-
T
H
S
R
A
D
L
A
L
-----------------
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
----------
G
A
E
----
P
L
A
I
T
N
-
C
V
N
Y
G
D
P
D
V
-
D
P
V
G
--
L
S
A
M
M
T
A
L
K
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
Y
--------
N
T
Y
Q
G
K
--
P
I
P
P
T
L
V
--
V
G
M
L
G
K
V
N
P
Q
--
K
V
A
K
P
K
P
----------------
S
K
V
F
A
V
G
----
W
N
------------------------------------------------------------
D
----------
F
---
E
L
E
-
R
E
K
---------------------------
E
L
W
R
A
I
R
-
K
-------
L
S
E
E
G
A
F
I
L
S
S
S
Q
L
L
T
R
T
H
V
E
T
F
R
E
Y
G
L
K
I
E
---
V
K
L
P
-----
E
V
--------------------
R
---------------------------------------
P
-------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
42.31
16%
-28
- C5 -
-
2HS3
1
PURL_THEMA
A:
[50-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
G
N
A
G
V
V
N
L
D
D
---------
Y
Y
S
V
A
F
K
I
E
S
--
H
N
H
P
--
S
A
-----
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
V
L
A
M
----------
G
A
R
P
--
T
A
I
F
D
S
L
-
H
M
S
R
----------
I
I
D
G
I
I
E
G
I
A
D
Y
G
N
S
I
-
G
V
P
T
V
G
G
E
L
R
I
S
--------
S
L
Y
A
-----
H
N
P
L
V
N
--
V
L
A
A
G
V
V
R
N
D
--
M
L
V
D
S
K
A
----------------
S
---
R
P
G
----
Q
V
I
V
I
F
---
G
G
A
TGRD
G
I
H
G
A
S
F
A
S
E
DLT---
G
DKATKLS
I
Q
V
G
------------------
D
----------
P
---
F
A
E
-
K
M
L
-------
I
--------
E
-------
A
-
F
L
E
M
V
E
E
G
-
L
-------
V
E
G
A
Q
D
--
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
-
L
G
A
I
---
V
H
L
D
-----
R
V
--------------------
P
LREPDME
P
W
E
-----------------------------
I
-------------------------------------
L
I
--
S
E
----------
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
H
L
L
--
F
G
D
----
V
-------------
V
A
E
V
I
E
E
--
P
V
Y
R
V
M
Y
R
N
DLV
M
E
V
--
P
V
Q
L
L
A
N
A
P
E
E
D
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
37.86
17%
29
- C4 -
-
5IJL
-
DP2L_PYRAB
A:
[9-1044]
---
P
K
E
M
E
E
Y
F
E
M
L
Q
R
E
I
-
D
K
A
Y
E
I
A
K
K
A
R
A
Q
-----
G
K
D
P
S
L
--
D
V
E
I
P
Q
A
T
---
D
M
A
G
--
R
V
E
S
L
V
G
P
P
--------
G
V
A
K
R
I
R
E
L
V
K
E
Y
G
K
E
I
A
A
L
K
I
V
D
E
I
I
E
G
K
F
G
------------------------------------
D
L
G
S
R
E
K
Y
A
E
Q
------
A
V
R
T
A
L
A
I
L
T
E
G
I
V
----
S
A
P
I
E
G
I
A
N
V
K
I
K
R
N
T
W
A
-----------------
D
N
S
E
Y
L
A
L
Y
Y
A
-
G
P
I
R
S
S
-
G
G
T
A
Q
A
L
S
V
L
V
G
D
Y
V
R
R
K
L
G
L
D
R
F
----
K
P
S
E
K
H
I
E
R
M
V
E
E
V
D
L
Y
H
R
A
V
T
R
L
Q
Y
H
P
S
-
P
E
E
V
R
L
A
M
R
N
I
P
I
------
E
I
T
G
E
A
T
D
D
V
E
V
S
H
R
----------
D
V
P
G
V
E
T
N
Q
L
R
----------------
G
G
A
I
L
V
L
A
E
G
V
L
Q
---------
K
--------
A
K
K
L
-
V
K
---
Y
I
--------
D
K
M
G
I
E
G
W
E
W
L
K
E
F
V
E
A
K
E
K
G
V
--------------------
D
M
G
F
Y
Y
S
L
Y
--
Q
K
F
K
E
E
P
L
F
S
D
----------------
P
S
K
P
G
G
F
-
R
L
------------
R
Y
G
R
S
W
G
IN
P
A
T
M
-----
I
L
V
G
A
V
V
T
P
V
T
T
I
E
G
P
I
V
K
L
K
D
G
S
V
L
R
V
D
D
------
Y
N
L
A
L
K
V
R
E
D
V
E
E
----
I
L
Y
L
G
D
A
V
I
A
F
G
D
Q
T
L
L
P
A
N
Y
C
E
E
W
W
I
L
E
F
V
----
K
----
A
L
K
-
E
I
Y
E
V
H
L
E
P
F
T
E
N
-
E
E
E
S
I
-
E
E
A
S
D
Y
L
E
I
--
D
P
E
F
L
K
E
M
L
R
D
P
L
R
V
K
P
P
V
E
L
A
I
-
H
F
S
E
V
LGIPLH
P
Y
Y
T
L
Y
W
N
--
S
V
E
P
K
D
V
E
K
L
W
R
L
L
K
N
Y
A
E
I
E
W
S
N
F
--
R
G
I
------
K
F
A
K
K
I
V
I
S
Q
E
K
L
G
D
S
K
R
T
L
E
L
L
G
L
----
P
H
T
V
R
D
G
--
N
V
I
V
D
Y
P
W
A
A
A
L
L
T
-
P
L
G
N
L
-------------------------------------------
N
-----
W
E
F
M
A
K
P
L
Y
A
T
I
D
I
I
N
E
N
---------------
N
E
I
K
L
R
-----------
D
R
G
I
-
S
W
I
G
K
P
P
V
Q
V
L
------
F
P
I
-
G
L
A
G
G
S
S
R
D
I
K
K
--------
A
A
E
E
G
K
--
V
A
E
V
E
I
A
--
F
F
K
C
P
K
C
G
H
V
GP
E
H
L
C
P
N
C
----------------
G
---
T
R
K
----
E
L
L
W
V
C
---
P
--------------------------------------------------------------------------------------------------------
R
C
N
A
-
E
-------
Y
P
E
S
Q
A
--
E
G
Y
N
Y
T
C
P
K
C
N
V
-
K
L
R
P
Y
-
A
K
R
K
---
I
R
P
S
-----
E
L
--------------------
L
---------------------------------------
N
-------------------------------------
R
A
--
M
E
----------
N
V
K
V
Y
G
V
D
K
L
K
G
V
M
--------------
G
M
T
SGWK
M
-------------
P
E
P
L
E
K
G
--
L
L
R
A
K
N
--
D
---
V
Y
V
F
K
D
G
T
I
R
F
D
A
T
D
A
P
I
T
H
F
R
P
R
E
I
G
V
S
V
E
K
L
R
E
L
G
-----------------------------------
Y
T
H
D
F
E
--------
G
--------
K
P
L
V
S
E
D
Q
I
V
E
L
K
P
Q
D
I
I
L
S
K
E
--
A
G
R
Y
L
L
K
V
A
K
F
V
D
D
L
L
E
K
F
Y
--
G
L
P
R
F
Y
N
A
E
K
M
E
D
L
I
G
H
L
V
I
G
L
A
P
H
T
S
---------
A
G
I
V
G
-
R
--
I
I
G
F
V
D
A
L
V
-
G
Y
A
---
H
P
Y
--
F
H
A
A
K
R
R
N
C
-----
D
G
D
E
D
A
V
M
L
L
L
D
A
L
L
N
F
S
R
Y
Y
L
P
E
K
R
G
G
K
M
D
A
P
--------
L
V
I
T
T
------------------------
R
L
D
P
R
Y
----------------------------
Y
P
L
E
F
Y
E
A
T
Y
E
L
K
S
P
K
E
L
V
G
V
I
E
R
V
E
D
-
46
Fugue
35.02
18%
43
- C4 -
-
4W8J
-
CR1AC_BACTK
A:
[33-1178]
-YT
P
I
D
I
S
L
S
L
T
Q
F
L
L
S
E
F
V
P
G
A
G
F
V
L
G
L
V
D
I
I
WGIF
G
P
S
Q
W
D
--
A
F
-
L
V
Q
I
E
---
Q
L
I
N
QR
I
E
E
F
A
R
N
Q
A
I
S
R
L
E
G
L
S
N
L
Y
Q
I
Y
A
E
S
F
R
E
W
E
A
D
P
T
N
P
A
L
R
E
E
M
-
R
I
Q
F
N
D
M
N
S
A
L
T
T
A
I
P
L
L
-
A
V
Q
N
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Q
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P
L
L
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V
Y
V
Q
A
A
N
L
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L
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V
L
R
D
V
S
V
F
G
Q
R
WGFD
A
A
T
I
N
S
R
Y
N
D
L
T
R
L
I
G
N
Y
T
D
Y
A
V
R
W
Y
N
T
G
L
E
R
V
W
G
P
D
S
R
D
W
V
R
Y
N
Q
F
R
R
E
L
T
L
T
V
L
D
I
V
A
L
F
P
N
Y
D
-
S
-
R
R
Y
P
I
R
T
V
S
Q
L
T
R
E
I
Y
T
N
P
V
L
E
N
-
F
D
G
S
F
----
R
G
---
S
A
Q
G
I
E
R
S
I
---------------
R
S
P
H
L
M
D
I
L
N
S
I
T
I
Y
T
D
A
--
H
R
G
----
Y
Y
Y
W
S
G
H
Q
I
M
A
S
P
V
G
F
S
G
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--
E
F
T
F
P
L
Y
G
T
M
G
N
A
A
P
Q
Q
R
I
V
A
Q
L
G
Q
G
V
Y
R
T
L
S
S
T
L
Y
R
---------
R
P
F
NQ
Q
L
S
V
L
D
G
T
-
E
F
---
A
Y
G
T
S
S
N
L
P
S
A
V
Y
R
K
S
G
T
V
D
S
L
D
E
I
P
P
Q
N
N
N
V
P
P
R
Q
G
F
S
H
R
-----
L
S
H
V
S
M
F
R
S
G
F
V
S
I
I
--
R
A
P
M
F
S
W
I
H
R
------------------
S
A
E
V
N
N
-
I
I
-----------------
A
S
---
D
S
I
-----
T
Q
I
P
--------------------------------
A
V
K
G
N
-------------
F
L
F
N
G
S
V
I
S
--------
G
P
G
--------
F
T
----
G
----
G
D
L
V
R
L
N
S
S
N
I
Q
N
R
G
Y
I
E
V
P
I
H
F
-
P
S
T
S
T
R
Y
R
V
R
V
R
Y
A
S
V
T
P
------------------------------------------
I
H
L
N
V
N
W
G
N
S
S
I
F
S
N
T
V
P
A
T
A
T
S
L
D
-------
N
L
Q
S
S
D
F
G
Y
F
E
S
A
N
A
F
T
G
N
I
V
G
-
V
R
----
N
F
S
G
T
A
G
---
V
I
I
D
-
R
F
E
F
I
P
V
T
A
T
L
E
A
E
Y
N
L
E
R
A
Q
K
A
V
N
A
L
F
T
STN
Q
L
G
L
K
T
N
V
T
D
Y
H
I
D
Q
V
--
S
N
L
V
--
T
Y
-----
L
S
D
E
F
S
--
L
D
E
K
R
E
L
S
E
K
V
K
H
----------
A
K
R
L
S
D
E
R
N
L
L
Q
D
S
N
F
K
D
I
N
R
E
R
-
G
W
G
G
S
T
---------------
G
I
T
I
Q
G
G
D
D
V
F
K
--------
E
N
Y
V
T
L
S
G
T
F
D
E
S
Y
P
--
T
Y
L
Y
Q
K
I
D
E
S
--
K
L
K
A
------------------------------
F
T
R
Y
Q
L
---
R
G
Y
----
I
E
D
------
S
------
Q
D---------
L
------------------
E
----------
I
---
Y
L
I
-
R
Y
N
----------------
A
-------
K
-
H
E
T
V
N
V
P
G
-
T
-------
G
S
S
A
H
H
--
S
H
H
F
S
L
D
I
D
V
G
S
T
D
L
N
E
D
-
L
G
V
W
---
V
I
F
K
-----
I
K
--------------------
T
---------------------------------------
Q
-------------------------------------
D
G
--
H
A
----------
R
L
G
N
L
E
F
L
E
E
K
P
L
V
--------------
G
--------------------------------------------------------
E
A
L
A
R
V
K
R
A
E
K
-
K
W
R
D
K
R
E
K
L
E
W
E
T
----------
N
I
V
Y
K
E
A
K
------
E
S
V
D
A
L
F
V
----------------
N
S
Q
Y
D
Q
L
Q
A
------
D
T
N
I
A
M
I
H
A
A
D
K
R
V
H
S
I
R
E
A
Y
L
P
E
L
S
V
I
P
G
V
N
-------------------
A
A
I
F
E
E
L
E
G
R
I
F
T
A
F
S
L
Y
D
A
R
-
N
V
I
K
N
G
D
F
--
N
N
G
L
S
S
W
N
V
-
K
G
H
---
V
---
D
V
E
E
Q
N
N
Q
R
S
V
L
V
V
P
E
W
E
A
E
V
S
Q
E
V
R
---
V
S
P
G
R
G
Y
I
L
R
V
T
A
Y
K
E
-----
G
Y
G
E
G
S
V
T
I
H
E
I
-
E
N
---
N
T
D
E
L
K
F
S
N
P
V
G
Y
---
V
T
K
E
L
E
Y
F
P
E
T
--------------------------
D
K
V
W
I
E
I
G
E
T
E
G
T
F
I
V
D
S
V
E
L
L
L
M
E
E
26
HHSearch
33.45
16%
-20
- C5 -
-
2YYE
2
SELD_AQUAE
B:
[50-343]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
D
D
A
G
V
Y
E
H
N
----------
G
I
I
W
V
Y
T
V
D
I
--
I
T
P
V
---
V
-----
N
D
P
Y
L
W
G
A
I
S
T
A
N
A
L
S
D
V
Y
A
M
----------
G
G
I
P
V
N
A
--
L
A
I
S
-
C
F
N
N
C
E
L
-
D
-
I
--
E
I
F
R
E
V
I
R
G
A
L
D
K
L
R
E
A
-
K
T
V
L
L
G
G
H
T
I
D
D
--------
K
---------
E
P
K
F
G
--
L
S
V
A
G
I
C
P
E
G
--
K
Y
I
T
Q
S
G
----------------
A
---
Q
V
G
----
Q
L
L
I
L
T
---
K
P
I
----
G
T
G
I
L
I
K
--
G
L
K
E
G--
I
----------
L
------------------
K
----------
E
---
E
D
I
-
N
E
A
-------
I
--------
E
N
M
L
ALN
D
K
-
A
R
N
L
M
L
S
L
-
D
-------
A
T
A
C
T
D
--
V
T
G
F
G
L
L
G
H
A
W
N
I
C
K
N
S
N
-
I
G
A
R
---
I
F
F
E
-----
K
V
--------------------
P
Y
Y
Q
L
S
E
N
L
V
K
K
KIYPK
G
A
I
E
N
L
N
F
V
KNYLKSNLD
N
W
K
L
I
L
-------------------------------------
L
S
--
D
P
V---------
T
S
G
G
L
L
F
T
I
N
K
E
K
L
EK
I
D
E
T
A
K
E
L
E
V
--
N
Y
W
----
I
-------------
I
G
E
T
I
A
E
--
N
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
32.96
15%
5
- C4 -
-
4MT1
-
?
A:
[2-1040]
A
K
F
F
I
D
R
P
I
F
A
W
V
I
S
I
F
I
-
I
A
A
G
I
F
G
I
K
S
L
P
V
S
----
Q
Y
P
S
V
A
A
P
T
I
T
L
H
A
I
Y
PGA
S
A
Q
V
--
M
E
G
S
V
L
S
V
I
E
R
N
M
N
G
V
E
G
----
L
D
Y
M
S
T
S
A
D
S
S
G
S
G
S
V
S
L
T
F
T
-
P
D
T
--
D
E
N
L
A
Q
V
E
V
Q
N
K
L
S
E
V
L
S
T
L
P
A
T
V
Q
Q
Y
G
V
--
T
V
S
K
A
R
S
N
F
L
M
I
V
M
L
S
------
S
-
D
V
Q
S
T
E
E
M
N
D
Y
A
Q
R
N
V
V
P
E
L
Q
R
I
E
G
V
G
Q
V
R
L
F
G
A
Q
R
A
M
R
I
-
W
V
D
P
K
K
L
Q
N
Y
N
--
L
S
F
A
D
V
G
S
-
A
L
S
A
Q
N
I
Q
I
S
A
G
S
I
G
S
L
P
A
V
R
G
Q
T
V
T
A
T
V
T
A
----
Q
G
Q
L
G
T
A
E
E
F
G
N
---------
V
I
L
R
A
N
--
T
D
G
S
N
I
Y
L
K
D
V
A
K
V
G
L
G
M
--
E
D
Y
S
S
------------------
S
T
R
L
N
G
V
N
T
T
G
M
A
V
M
L
S
N
S
G
N
A
M
A
T
A
K
A
V
K
E
R
L
A
V
L
E
K
Y
F
P
Q
---------
G
--------
M
S
W
K
-
T
---------------------------
P
Y
D
T
S
K
F
V
E
I
S
I
E
K
V
I
H
T
-----
L
I
E
A
M
V
L
V
F
V
V
M
Y
L
F
--
L
Q
N
I
R
Y
T
L
I
P
T
I
V
V
P
I
S
L
L
G
G
----
F
A
F
I
S
Y
M
G
M
---------------
S
I
N
V
L
T
M
---
F
A
M
-----
I
L
V
I
G
I
-
V
V
D
D
A
I
V
V
V
E
N
V
E
R
I
M
A
G
E
G
L
P
P
K
E
--
A
T
K
K
A
M
G
Q
I
S
G
A
V
I
G
----
I
T
A
V
L
I
S
V
F
V
P
L
A
M
F
S
----
G
A
A
G
N
I
Y
K
Q
F
A
----
L
----
T
M
A
S
S
I
A
F
S
A
F
L
A
L
T
L
T
P
A
L
C
A
T
G
F
F
G
W
F
N
K
K
F
D
S
W
T
H
G
Y
E
G
R
V
A
K
V
L
R
K
T
F
R
M
M
V
V
Y
-
I
G
L
A
V
------
V
G
V
F
L
F
M
R
--------
L
P
T
S
F
L
P
T
E
------
D
Q
G
F
V
M
V
S
V
------
Q
L
P
A
----------------------------------------
G
A
T
K
E
R
T
D
A
T
L
A
Q
V
T
Q
L
A
K
S
I
P
E
I
E
N
I
I
T
---
V
S
G
F
-
S
F
S
G
S
----------------------------------------------------
G
Q
N
M
A
M
G
F
A
I
F
K
D
-
W
N
E
R
T
A
S
------
G
S
D
A
V
A
V
A
G
K
L
T
G
M
M
M
G
-
T
L
K
-----------------
D
G
F
G
I
A
--
V
V
P
P
P
I
L
--
E
L
G
S
-----------
G
L
S
I
----------------
N
---
L
Q
D
----
R
N
------------------------------
N
----------
T
------------------
G
----------
H
---
T
A
L
-
L
A
K
-------
R
--------
N
-------
E
-
L
I
Q
K
M
R
A
S
-
G
-------
L
F
D
P
S
T
--
V
R
A
G
G
L
E
D
S
P
Q
L
K
I
D
I
N
R
-
A
A
A
A
A
QG
I
S
F
A
-----
D
I
--------------------
R
---------------------------------------
T
-------------------------------------
A
L
--
A
S
----------
A
L
S
S
-----------------------------------------------
S
Y
V
S
D
--
F
P
-----------------------
N
Q
G
R
L
Q
R
V
M
V
Q
A
D
-
E
D
A
R
M
---
Q
P
A
D
I
----------
L
N
L
T
V
P
N
K
------
S
G
V
A
V
P
L
S
T
I
A
T
V
S
--------
W
E
N
G
T
E
Q
S
V
R
F
N
G
Y
P
S
M
K
L
S
A
S
P
A
T
G
V
S
T
G
Q
--
A
M
E
A
V
Q
K
M
V
D
E
L
G
G
-
G
Y
S
F
E
W
G
G
Q
S
S
E
E
A
K
G
G
S
Q
T
L
I
L
Y
G
L
A
V
A
A
V
F
L
V
L
A
A
L
Y
E
S
-
W
S
I
P
L
A
-
V
I
L
V
I
P
L
G
L
I
G
A
-
A
A
G
---
V
T
G
R
N
L
F
E
G
L
L
G
S
V
P
S
F
A
N
D
I
Y
F
Q
V
G
F
V
T
V
M
G
L
S
A
K
N
A
I
L
I
I
E
F
A
K
D
L
Q
A
Q
------
G
K
S
A
V
E
A
A
L
-
E
A
A
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
L
Y
I
A
A
G
A
S
S
A
S
Q
R
A
I
G
T
T
V
F
W
G
M
L
V
G
T
L
L
S
V
F
L
V
--------------
P
L
F
Y
V
V
V
R
K
F
F
--
21
HHSearch
32.07
16%
-3
- C5 -
-
5CM7
4
?
A:
[9-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
E
F
S
I
-
I
D
Q
Y
F
N
R
Q
S
H
P
D
V
A
--
L
G
I
------
G
D
D
S
A
L
I
T
P
P
P
---------
N
Q
Q
L
V
I
C
A
D
T
L
V
A
G
R
H
FP
L
E
-----
T
S
P
H
A
I
G
W
K
S
V
A
V
N
L
S
D
I
A
A
M
----------
G
A
K
P
H
--
S
I
L
L
A
I
-
S
L
P
Q
V
---
D
-
H
E
W
--
L
E
G
F
S
Q
G
I
Y
D
C
C
N
Q
F
-
G
V
A
L
I
G
G
D
T
T
Q
G
--------
P
---------
H
L
T
I
T
--
V
T
A
M
G
W
I
E
T
G
--
K
A
V
L
R
S
G
----------------
A
---
K
V
G
----
D
Y
V
C
V
S
---
G
Q
I
----
G
D
A
A
Y
----
G
------
L
Q
H
--------
L
------------------
G
----------
H
---
S
L
Q
-
Q
R
L
D
Y
PTPR-
C
--------
K
-------
L
-
G
E
E
L
--
K
G
-
L
-------
A
S
S
M
I
D
--
V
S
D
-
G
L
A
Q
D
L
G
H
I
L
K
A
S
K
-
V
G
A
R
---
L
I
L
E
-----
K
L
--------------------
P
VD
P
V
L
Q
Q
IE
E
Q
Q
R
W
Q
Y
-----------------------
A
-------------------------------------
L
A
--
G
G
----------
D
D
Y
E
L
C
F
T
I
T
P
Q
N
Y
E
K
L
L
Q
KQLD
V
----
K
I
T
----
M
-------------
I
G
Q
I
V
E
Q
--
T
K
L
T
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
31.67
14%
-5
- C4 -
-
1L5J
1
ACNB_ECOLI
A:
[1-862]
---
M
L
E
E
Y
R
K
H
V
A
E
R
A
A
E
-------------
G
I
----
A
P
K
P
L
D
--
A
N
Q
M
A
A
L
V
---
E
L
L
K
--
N
P
P
A
G
E
E
E
F
L
L
D
L
L
T
N
R
V
P
------
P
G
V
D
E
A
A
Y
V
K
A
G
F
L
A
A
I
A
-
K
G
E
A
K
S
P
L
L
T
P
E
K
A
I
E
L
L
G
T
M
Q
G
------------------------
G
Y
N
I
H
------
P
L
I
D
A
L
D
D
------
A
K
L
A
P
I
A
A
K
A
L
S
H
T
L
L
M
F
D
N
F
Y
D
V
E
E
K
A
-
K
A
G
N
E
Y
A
K
Q
V
M
Q
S
W
A
D
A
E
W
F
L
-
N
R
P
A
L
A
E
K
L
T
V
T
V
F
K
V
T
G
-------------------------------
E
T
N
T
D
D
L
S
P
A
P
D
A
W
S
R
P
D
I
P
L
H
A
L
A
M
------------------------
L
K
N
A
R
E
G
I
E
P
D
Q
P
G
V
V
G
P
I
K
Q
I
E
A
L
Q
Q
K
G
F
P
---------
L
A
Y
V
G
D
V
V
G
T
---------
G
--------
S
S
R
K
-
S
A
---
T
N
--------
S
V
L
W
F
M
G
D
D
I
P
H
V
P
-
N
K
R
G
G
G
L
C
L
G
G
K
I
A
P
I
-----
F
F
N
T
M
E
D
A
G
A
-
L
P
I
E
--
V
D
-----------
V
S
N
L
N
M
G
D
----
V
I
D
V
Y
P
Y
K
G
-
E
V
------------
R
N
H
E
T
-
G
---
E
L
L
-----
A
T
F
---------------
E
L
K
T
D
V
L
I
D
E
V
R
A
G
G
R
I
P
L
I
I
G
R
G
L
T
T
K
A
R
E
----
A
L
G
L
P
H
S
D
V
F
R
Q
A
K
D
V
A
E
S
D
R
G
F
S
L
A
Q
K
M
V
G
----
R
----
A
C
G
V
K
--------
G
I
R
P
G
A
Y
C
E
P
---------------------------
K
M
T
S
V
G
S
Q
-
D
T
T
------------
G
P
M
T
--
R
D
E
L
K
D
L
A
C
L
G
F
S
A
D
L
V
M
Q
S
F
C
H
T
A
A
Y
P
K
P
------
V
D
V
N
T
H
H
T
L
P
D
F
I
M
N
R
G
G
V
S
L
R
-
P
G
----
D
G
V
I
H
S
W
-
L
N
R
M
-------------------
L
L
P
D
T
V
G
T
G
---------
G
D
-
S
H
T
R
F
P
I
G
I
S
F
--
P
---------------------
A
G
S
G
L
V
A
F
A
A
A
T
----------
G
V
M
P
L
D
M
P
E
S
V
L
V
-
R
F
K
G
K
M
Q
P
G
-
I
T
L
R
D
L
V
H
A
I
P
L
Y
A
I
K
Q
G
L
L
-
T
V
E
K
K
G
K
K
N
I
F
S
--------
G
R
I
L
E
I
--
E
G
L
P
D
L
--------
K
V
E
Q
A
--
F
E
L
T
D
A
S
----------------
A
---
E
R
S
----
A
A
G
C
T
I
---
K
-------
L
N
------
K
------
E
----------
P
------------------
I
----------
I
---
E
Y
L
-
N
S
N
-------
I
--------
V
-------
L
-
L
K
W
M
I
A
E
G
-
Y
-------
G
D
R
R
T
L
--
E
R
R
I
Q
G
M
E
K
W
L
A
N
P
E
L
L
E
-
A
D
A
D
---
A
E
Y
A
-----
A
V
--------------------
I
---------------------------------------
D
-------------------------------------
I
D
--
L
A
----------
D
I
K
E
P
I
L
C
A
P
N
D
P
D
--------------
D
A
R
----
P
-------------
L
S
A
V
Q
----------------------
G
E
K
I
D
E
V
F
I
G
S
C
-----------
M
T
N
I
G
H
F
R
A
A
G
----------
K
--
L
L
D
A
H
------
K
G
--
Q
L
P
T
R
L
W
V
A
P
--------
P
T
R
M
D
A
A
Q
L
T
E
---------------------------
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
--------------------
M
G
N
Q
A
R
V
A
D
-
G
A
T
V
V
S
-
T
--
S
T
R
-----------------
N
F
P
N
R
L
G
T
G
A
N
V
F
L
A
S
A
E
L
A
A
V
A
A
L
I
G
K
L
P
T
-------------------------
P
E
E
Y
Q
T
-
Y
V
A
Q
V
D
K
T
A
V
D
T
Y
R
Y
L
N
F
N
Q
L
-----------------------------
S
Q
Y
T
E
K
A
D
G
V
I
F
Q
---------------------
28
HHSearch
31.65
13%
-4
- C5 -
-
3WJP
8
?
A:
[41-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
G
A
T
I
P
F
G
----------
D
K
H
I
V
F
T
I
D
G
--
H
T
V
K
P-
L
F
-----
F
P
G
G
D
I
G
R
L
A
V
S
G
T
V
N
D
L
A
V
M
----------
G
A
E
P
--
I
A
L
A
N
S
M
-
I
I
G
E
G
L
--
D
-
M
--
E
V
L
K
R
V
L
K
S
M
D
E
T
A
R
E
V
-
P
V
P
I
V
T
G
D
T
K
V
V
--------
E
D
K
I
------
E
M
F
V
I
--
T
A
G
I
G
I
A
E
----
H
P
V
S
D
A
G
----------------
A
---
K
V
G
----
D
A
V
L
V
S
---
G
T
I
----
G
D
H
------
G
I
A
L
M
S
H
R
E
GIA------
F
------------------
E
TELKSD----
V
---
A
P
I
-
W
D
V
-------
V
--------
K
-------
A
-
V
A
E
T
I
G
W
E
-
N
-------
I
H
A
M
K
D
--
P
T
R
A
G
L
S
N
A
L
N
E
I
A
R
K
S
N
-
V
G
I
L
---
V
R
E
A
-----
D
I
--------------------
P
IR
P
E
V
----------------------------------
R
-------------------------------------
A
A
--
S
E
M
L
GISPYD
V
A
N
E
G
K
V
V
M
V
V
A
R
E
Y
A
E
E
A
L
E
A
M
R
K
TEKGR
N
A
A
----
I
-------------
I
G
E
V
I
A
D
YR
G
K
V
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
31.60
36%
-137
- C3 -
-
3OPY
-
PFKA1_PICPA
A:
[613-669]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
A
T
R
V
A
T
L
N
S
L
A
K
-
G
H
R
V
F
A
-
I
--
R
N
G
F
A
G
L
I
R
-
H
G
A
V
R
E
L
N
W
I
D
V
E
D
W
H
N
T
-------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
31.38
11%
-17
- C5 -
-
5VK4
2
?
B:
[49-342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
A
L
V
E
I
G
K
-----
K
Y
-
Q
N
P
V
L
V
S
G
T
D
G
--
V
G
T
K
--
L
K
L
A
F
D
W
D
K
H
D
T
V
G
I
D
L
V
A
M
S
V
N
D
I
L
V
Q
----------
G
A
E
P
--
L
F
F
L
D
Y
F
-
A
C
G
K
L
---
D
-
V
--
P
R
A
T
D
V
I
K
G
I
A
Q
G
C
E
E
S
-
G
C
A
L
I
G
G
E
T
A
E
M
--------
P
G
M
Y
-
P
--
V
G
E
Y
D
L
A
--
G
F
A
V
G
V
V
E
K
E
--
N
V
I
T
G
L
S
----------------
V
---
G
A
G
----
D
M
V
L
G
L
---
A
S
N
----
G
A
H
SN----
G
------
Y
----------
S
L
I
R
K
I
I
E
R
DNPDLDAEFD
N
----------
G
---
K
T
L
-
R
E
A
V
I
APTRL
Y
V
-------
K
-------
P
-
I
L
A
A
L
E
K
F
-
T
-------
I
K
G
M
A
H
--
I
T
G
G
G
I
T
E
N
V
P
R
V
L
P
K
-
N
-
T
V
A
Q
---
I
D
A
E
-----
S
W
ELP
K
L
F
Q
W
L
Q
K
A
G
NVE
T
Q
E
M
Y
---------------------------------------
R
-------------------------------------
T
F
--
N
C
----------
G
I
-
G
M
V
V
I
V
A
A
E
D
A
D
A
V
R
S
F
L
S
G
Q
G
E
--
T
V
Y
----
R
-------------
L
G
C
I
R
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
31.37
15%
-30
- C5 -
-
3U0O
-
SELD_ECOLI
A:
[49-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
D
A
A
V
Y
D
L
G
N
---------
G
T
S
V
I
S
T
T
D
F
--
F
M
P
---
I
V
-----
D
N
P
F
D
F
G
R
I
A
A
T
N
A
I
S
D
I
F
A
M
----------
G
G
K
P
I
M
A
--
I
A
I
L
-
G
W
P
I
N
K
L
-
S
-
P
--
E
I
A
R
E
V
T
E
G
G
R
Y
A
C
R
Q
A
-
G
I
A
L
A
G
G
H
S
I
D
A
--------
P
---------
E
P
I
F
G
--
L
A
V
T
G
I
V
P
T
E
--
R
V
K
K
N
S
T
----------------
A
---
Q
A
G
----
C
K
L
F
L
T
---
K
P
L
----
G
I
G
V
L
----
T
T
A
E
K
K
S
L
----------
L
------------------
K
----------
P
EHQ
G
L
A
-
T
E
V
M
C
R----
M
--------
N
-------
I
A
G
A
S
F
A
N
I
E
-
G
-------
V
K
A
M
T
D
--
V
T
G
F
G
L
L
G
H
L
S
E
M
C
Q
G
A
G
-
V
Q
A
R
---
V
D
Y
E
-----
A
I
--------------------
P
---------------------------------------
K
L
PG
V
E
E
Y
I
KLGAVP
G
G
T
E
R
N
F
A
S
YGHLMGEMP
R
E
V
R
D
L
L
C
D
P
Q
----------
T
S
G
G
L
L
L
A
V
M
P
E
A
E
N
E
V
K
A
T
A
A
E
F
G
I
--
E
L
T
----
A
-------------
I
G
E
L
V
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
30.23
13%
-38
- C5 -
-
3FD5
2
SPS1_HUMAN
B:
[69-379]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
D
T
C
V
I
P
L
R
H
--------
G
G
L
S
L
V
Q
T
T
D
Y
--
I
Y
P
I
---
V
-----
D
D
P
Y
M
M
G
R
I
A
C
A
N
V
L
S
D
L
Y
A
M
----------
G
V
T
E
C
D
N
-
M
L
M
L
L
-
G
V
S
N
K
M
T
D
R
-
E
R
D
K
V
M
P
L
I
I
Q
G
F
K
D
A
A
E
E
A
-
G
T
S
V
T
G
G
Q
T
V
L
N
--------
P
---------
W
I
V
L
G
--
G
V
A
T
T
V
C
Q
P
N
--
E
F
I
M
P
D
N
----------------
A
---
V
P
G
----
D
V
L
V
L
T
---
K
P
L
----
G
T
Q
V
A
----
V
A
V
----
H
Q
W
L
D
I
P
E
K
--
W
------------------
N
K
IKLVVT
Q
E
D
V
---
E
L
A
Y
Q
E
A
-------
M
M
N
M
A
RLN-
R
-------
T
-
A
A
G
L
M
H
T
F
-
N
-------
A
H
A
A
T
D
--
I
T
G
F
G
I
L
G
H
A
Q
N
L
A
K
Q
Q
R
-
N
E
V
S
---
F
V
I
H
-----
N
L
--------------------
P
V
LAK
M
A
A
V
S
K
A
C
GNMFGLMH-------------------
G
-------------------------------------
T
C
--
P
E
----------
T
S
G
G
L
L
I
C
L
P
R
E
Q
A
A
R
F
C
A
E
I
K
S
PE
G
H
-
Q
A
W
----
I
-------------
I
G
I
V
E
K
G
N-
R
T
A
R
I
I
D-
K
P
R
I
I
E
V
--
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------