@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0052: (2017-12-14 )
MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLELVNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKAFGPTRAAAELEWSKDFAKEIMVKYGVSTAAYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVAETVEQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFVNGDKFYIMPTAQDHKRAYDGDKGPNTGGMGAYAPVPHLPQSVVDTAVDTIVKPVLEGIIKEGRPYLGVIYAGLILTADGPKVIEFNSRFGDPETQIILPRLTSDFAQNITDILDGKEPNIMWTDKGVTLGVVVASKGYPLDYERGVELPAKTEGDVITYYAGAKFAENSRALLSNGGRVYMLVTTADTVKEAQASIYQELSQQKIEGLFYRTDIGSKAIK
Atome Classification :
(21 SA)
........-.10.-....-....20......-..30.-.-.-..-.---.-.-40..-.......50........60........70........80........90........100.......110.......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230.......-240.......-.-----250........260.......270.....-..-280.......290.......300.......310....--...-320--.-.......330..---.....340..-----.---.---..--.350--.----.---..----...---.-----------.360.......370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
L
L
V
VGS-GG-R-
E
H
A
I
-
A
K
K
L
L
E
SKDV
E
K
-
V
F
VAP-G-N-DG-
M
---
T
-L-D-
G
L
-
E
L
V
N
I
SISEH
S
K
L
I
D
F
AKTN
D
V
A
W
T
F
IGP
D
D
A
L
A
A
G
I
V
D
D
F
N
QA
G
L
K
AFGPTR
A
A
A
E
L
E
W
S
K
D
F
A
K
E
I
M
V
K
YGVSTAAYGT
F
S
D
F
E
E
A
K
A
Y
I
E
KHG
A
P
-
I
V
V
KADGLALGKG
V
V
V
A
E
T
V
E
Q
A
V
E
A
A
H
E
M
L
L
DNKFGDS
G
A
R
V
V
I
E
E
F
LEGE
E
F
S
L
F
A
F
VNG
D
K
F
Y
I
M
PTA
Q
D
H
K
RAYDGDKGPNTGGMGAYAPVPHL
P
-
Q
S
-
V
V
D
T
A
V
D
-
T
-----
I
-
V
K
P
V
L
E
G
I
I
KEGR
P
Y
L
G
V
I
Y
A
G
L
I
L
TA-DG-
P
K
V
I
E
FNSRFGDPE
T
Q
I
I
L
P
R
L
T
S
D
F
A
Q
N
I
T
D
I
LDGK--EP
N
-
I
-
M
--
W
-TDKG
V
T
L
G
V
V
V
A---SKGYPL
D
Y
E
R-----G---V---EL--PA----K----T---EG----
D
V
I
---
T
-----------
Y
YAGAKFAEN
S
R
A
L
L
SNG
G
R
V
Y
M
L
V
TT
A
D
T
V
K
E
A
Q
A
S
I
Y
Q
E
L
S
Q
Q
K
I
E
G
L
F
Y
RTDIGSKAIK
3
PsiBlast_PDB
86.42
53%
-81
- C1 -
-
2YS6
2
?
A:
[22-439]
M
N
V
L
V
I
G
R
-
G
G
-
R
-
E
H
A
I
-
A
W
K
A
A
Q
S
P
L
V
G
K
-
L
Y
V
A
P
-
G
-
N
-
P
G
-
I
---
A
---
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
D
E
-
M
M
D
A
A
L
E
-
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
D
G
K
--
E
L
E
-
L
-
E
--
W
-
T
D
E
A
V
-
L
G
V
V
L
A
---
A
K
G
Y
P
G
A
Y
E
R
-----
G
---
A
---
E
I
--
R
G
LD--
R
----
I
---
S
P
----
D
A
L
---
L
-----------
F
H
A
G
T
K
--
R
E
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
2
PsiBlast_PDB
85.85
53%
-81
- C1 -
-
2YRX
1
?
A:
[22-438]
M
N
V
L
V
I
G
R
-
G
G
-
R
-
E
H
A
I
-
A
W
K
A
A
Q
S
P
L
V
G
K
-
L
Y
V
A
P
-
G
-
N
-
P
G
-
I
---
A
---
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
D
E
-
M
M
D
A
A
L
E
-
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
D
G
K
--
E
L
E
-
L
-
E
--
W
-
T
D
E
A
V
-
L
G
V
V
L
A
---
A
K
G
Y
P
G
A
Y
E
R
-----
G
---
A
---
E
I
--
R
G
LD--
R
----
I
---
S
P
----
D
A
L
---
L
-----------
F
H
A
G
T
K
--
R
E
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
-
1
PsiBlast_PDB
84.42
53%
-83
- C1 -
-
2YRW
-
?
A:
[22-439]
M
N
V
L
V
I
G
R
-
G
G
-
R
-
E
H
A
I
-
A
W
K
A
A
Q
S
P
L
V
G
K
-
L
Y
V
A
P
-
G
-
N
-
P
G
-
I
---
A
---
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
------
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
D
E
-
M
M
D
A
A
L
E
-
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
D
G
K
--
E
L
E
-
L
-
E
--
W
-
T
D
E
A
V
-
L
G
V
V
L
A
---
A
K
G
Y
P
G
A
Y
E
R
-----
G
---
A
---
E
I
--
R
G
LD--
R
----
I
---
S
P
----
D
A
L
---
L
-----------
F
H
A
G
T
K
--
R
E
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
22
PsiBlast_CBE
83.30
48%
-67
- C1 -
-
2YW2
1
PUR2_AQUAE
B:
[1-420]
M
K
V
L
V
V
G
N
-
G
G
-
R
-
E
H
A
I
-
A
W
K
V
A
Q
S
P
L
V
K
E
-
L
Y
V
A
K
-
G
-
N
-
A
G
-
I
-----
W
-
E
-
I
A
-
K
R
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
T
P
V
I
N
-
E
E
-
V
E
K
R
I
R
E
-
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
E
G
K
--
D
V
H
-
I
-
K
----
E
D
E
R
Y
A
L
D
V
V
L
A
---
S
R
G
Y
P
E
K
P
E
T
-----
G
---
K
---
I
I
--
H
G
LDYL
K
----
S
---
M
E
----
D
V
V
---
V
-----------
F
H
A
G
T
K
--
K
E
G
N
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
8
PsiBlast_PDB
83.29
48%
-66
- C1 -
-
2YW2
1
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
-
G
G
-
R
-
E
H
A
I
-
A
W
K
V
A
Q
S
P
L
V
K
E
-
L
Y
V
A
K
-
G
-
N
-
A
G
-
I
-----
W
-
E
-
I
A
-
K
R
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
T
P
V
I
N
-
E
E
-
V
E
K
R
I
R
E
-
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
E
G
K
--
D
V
H
-
I
-
K
----
E
D
E
R
Y
A
L
D
V
V
L
A
---
S
R
G
Y
P
E
K
P
E
T
-----
G
---
K
---
I
I
--
H
G
L
D
Y
L
K
----
S
---
M
E
----
D
V
V
---
V
-----------
F
H
A
G
T
K
--
K
E
G
N
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
5
PsiBlast_PDB
82.75
53%
-59
- C1 -
-
2XD4
1
PUR2_BACSU
A:
[1-418]
M
N
V
L
I
I
G
K
-
G
G
-
R
-
E
H
T
L
-
A
W
K
A
A
Q
S
S
L
V
E
N
-
V
F
A
A
P
-
G
-
N
-
D
G
-
M
---
A
-
A
-
S
-
A
--
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
E
E
-
T
V
R
H
A
V
E
-
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
D
D
K
--
E
V
D
-
L
-
R
--
W
-
K
D
T
A
-
A
V
S
V
V
L
A
---
S
E
G
Y
P
E
S
Y
A
K
-----
G
---
T
PIG
S
L
--
A
A
----
E
----
T
---
E
-----
Q
V
V
---
V
-----------
F
H
A
G
T
K
-
A
E
G
G
E
-
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
9
PsiBlast_PDB
82.43
48%
-68
- C1 -
-
2YYA
-
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
-
G
G
-
R
-
E
H
A
I
-
A
W
K
V
A
Q
S
P
L
V
K
E
-
L
Y
V
A
K
-
G
-
N
-
A
G
-
I
-----
W
-
E
-
I
A
-
K
R
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
T
P
V
I
N
-
E
E
-
V
E
K
R
I
R
E
-
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
E
G
K
--
D
V
H
-
I
-
K
----
E
D
E
R
Y
A
L
D
V
V
L
A
---
S
R
G
Y
P
E
K
P
E
T
-----
G
---
K
---
I
I
--
H
G
L
D
Y
L
K
----
S
---
M
E
----
D
V
V
---
V
-----------
F
H
A
G
T
K
--
K
E
G
N
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
6
PsiBlast_PDB
82.40
52%
-66
- C1 -
-
2XCL
1
PUR2_BACSU
A:
[3-418]
--
V
L
I
I
G
K
-
G
G
-
R
-
E
H
T
L
-
A
W
K
A
A
Q
S
S
L
V
E
N
-
V
F
A
A
P
-
G
-
N
-
D
G
-
M
---
A
-
A
-
S
-
A
--
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
E
E
-
T
V
R
H
A
V
E
-
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
D
D
K
--
E
V
D
-
L
-
R
--
W
-
K
D
T
-
A
A
V
S
V
V
L
A
---
S
E
G
Y
P
E
S
Y
A
K
-----
G
---
T
PIG
S
L
--
A
A
----
E
----
T
---
E
-----
Q
V
V
---
V
-----------
F
H
A
G
T
K
-
A
E
G
G
E
-
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
45
HHSearch
79.56
51%
7
- C1 -
-
2YRX
1
?
A:
[22-438]
M
N
V
L
V
I
G
R
-
G
G
-
R
E
H
A
I
A
-
W
K
A
A
Q
S
P
--
L
V
G
-
K
L
Y
V
A
P
G
-
N
-
P
G
-
I
-----
A
-
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
D
E
M
M
D
A
A
L
-
E
-
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
D
G
K
--
E
L
E
-
L
-
E
--
W
-
T
D
-
E
A
V
L
G
V
V
L
A
---
A
K
G
Y
P
G
A
Y
E
R
-----
G
---
A
---
E
I
--
R
G
----
L
----
D
RI-
S
P
----
D
A
L
---
L
-----------
F
H
A
G
T
K
R
E
--
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
-
12
PsiBlast_PDB
79.54
45%
-9
- C1 -
-
3MJF
6
PUR2_YERPE
A:
[5-427]
-
N
I
L
I
I
G
N
-
G
G
-
R
-
E
H
A
L
-
G
W
K
A
A
Q
S
P
L
A
D
K
-
I
Y
V
A
P
-
G
-
N
-
A
G
-
T
---
A
-
L
-
E
P
T
L
-
E
N
V
D
I
A
A
T
D
I
A
G
L
L
A
F
A
Q
S
H
D
I
G
L
T
I
V
G
P
E
A
P
L
V
I
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
A
R
H
N
I
P
S
A
E
Y
Q
N
F
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
F
G
D
A
G
H
R
I
V
V
E
E
F
L
D
G
E
E
A
S
F
I
V
M
V
D
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
V
G
D
G
D
T
G
P
N
T
G
G
M
G
A
Y
S
P
A
P
V
V
T
-
D
D
-
V
H
Q
R
V
M
D
-
Q
-----
V
-
I
W
P
T
V
R
G
M
A
A
E
G
N
I
Y
T
G
F
L
Y
A
G
L
M
I
S
A
-
D
G
Q
P
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
L
R
M
R
S
D
L
V
E
L
C
L
A
G
T
Q
G
K
LN
E
K
T
-
S
-
D
--
W
--
D
E
R
P
S
L
G
V
V
L
A
---
A
G
G
Y
P
A
D
Y
R
Q
-----
G
D
V
I
H
---
G
L
--
P
Q
----
Q
----
E
---
V
K
----
D
G
K
---
V
-----------
F
H
A
G
T
K
L
N
G
N
H
E
-
V
V
T
N
G
G
R
V
L
C
V
T
A
L
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
Q
W
E
G
V
F
C
R
K
D
I
G
Y
R
A
I
-
44
HHSearch
79.11
51%
10
- C1 -
-
2YS6
2
?
A:
[22-439]
M
N
V
L
V
I
G
R
-
G
G
-
R
E
H
A
I
A
-
W
K
A
A
Q
S
P
--
L
V
G
-
K
L
Y
V
A
P
G
-
N
-
P
G
-
I
-----
A
-
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
-
D
E
M
M
D
A
A
L
-
E
-
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
D
G
K
--
E
L
E
-
L
-
E
--
W
-
T
D
-
E
A
V
L
G
V
V
L
A
---
A
K
G
Y
P
G
A
Y
E
R
-----
G
---
A
---
E
I
--
R
G
----
L
----
D
RI-
S
P
----
D
A
L
---
L
-----------
F
H
A
G
T
K
R
E
--
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
7
PsiBlast_PDB
78.08
47%
-63
- C1 -
-
5VEV
8
?
A:
[9-430]
M
K
L
L
V
I
G
N
-
G
G
-
R
-
E
H
A
L
-
A
W
K
L
A
Q
S
P
K
V
E
T
-
V
F
V
A
P
-
G
-
N
-
A
G
-
T
---
A
-
I
-
E
-
S
--
K
L
Q
N
I
A
L
T
A
Y
Q
D
L
I
E
F
C
R
K
E
N
I
V
F
T
V
V
G
P
E
A
P
L
A
A
G
I
V
D
D
F
R
A
A
G
L
K
I
F
G
P
T
Q
Y
A
A
Q
L
E
S
S
K
D
F
A
K
A
F
M
V
K
Y
N
I
P
T
A
Q
Y
Q
T
F
E
N
A
D
A
A
H
D
Y
V
N
Q
K
G
A
P
-
I
V
I
K
A
--------
V
I
V
A
M
T
L
D
E
A
H
A
A
I
D
D
M
-----------
R
V
V
I
E
D
F
L
Q
G
E
E
A
S
F
I
V
M
V
D
G
N
H
V
L
P
M
A
T
S
Q
D
H
K
R
L
L
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
A
P
V
V
T
-
P
A
-
V
Y
E
R
A
M
N
-
E
-----
I
-
I
L
P
T
V
A
G
M
K
A
E
G
H
E
F
T
G
F
L
Y
A
G
L
M
I
D
Q
-
S
G
A
P
Y
T
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
S
R
L
N
S
D
L
A
D
L
V
E
A
A
I
D
G
R
--
L
D
S
-
V
-
K
A
E
W
-
N
P
Q
-
T
A
V
G
V
V
L
A
---
A
Q
N
Y
P
------------------
E
T
--
P
K
----
K
---------
G
----
D
V
I
---
S
GLDDVNRI
G
K
V
F
H
A
G
T
T
V
N
E
K
G
D
-
V
L
T
N
G
G
R
I
L
C
V
V
G
L
G
D
D
V
A
Q
A
K
A
K
A
Y
G
A
L
E
K
I
S
F
D
G
M
Q
Y
R
K
D
I
A
D
K
A
I
N
14
PsiBlast_PDB
78.02
42%
-73
- C1 -
-
2IP4
-
?
A:
[2-412]
-
K
V
L
V
V
G
S
-
G
G
-
R
-
E
H
A
L
-
L
W
K
A
A
Q
S
P
R
V
K
R
-
L
Y
A
A
P
-
G
-
N
-
A
G
-
M
---
E
-
A
-
L
-
A
--
E
L
V
P
W
N
-
G
D
V
E
A
L
A
D
W
A
L
A
E
G
I
D
L
T
L
V
G
P
E
A
P
L
V
E
G
I
A
D
A
F
Q
A
R
G
L
L
L
F
G
P
T
Q
K
A
A
M
I
E
G
S
K
A
F
A
K
G
L
M
E
R
Y
G
I
P
T
A
R
Y
R
V
F
R
E
P
L
E
A
L
A
Y
L
E
E
V
G
V
P
-
V
V
V
K
D
S
G
L
A
A
G
K
G
V
T
V
A
F
D
L
H
Q
A
K
Q
A
V
A
N
I
L
--
N
R
--
A
E
G
G
E
V
V
V
E
E
Y
L
E
G
E
E
A
T
V
L
A
L
T
D
G
E
T
I
L
P
L
L
P
S
Q
D
H
K
R
L
L
D
G
D
Q
G
P
M
T
G
G
M
G
A
V
A
P
Y
P
M
-
D
-
E
A
-
T
L
R
R
V
E
E
-
E
-----
I
-
L
G
P
L
V
R
G
L
R
A
E
G
V
V
Y
R
G
V
V
Y
A
G
L
M
L
T
R
-
E
G
-
P
K
V
L
E
F
N
A
R
F
G
D
P
E
A
Q
A
L
L
P
L
L
E
N
D
L
V
E
L
A
L
R
V
A
E
G
R
LA
G
T
R
-
L
-
S
--
W
-
K
E
-
G
A
A
A
C
V
V
L
A
---
A
P
G
Y
P
E
S
P
R
K
-----
G
---
I
---
P
L
H
V
P
E
----
P
----
P
---
E
G
-----
V
L
---
V
-----------
F
H
A
G
T
R
-
R
E
G
G
R
-
L
V
S
A
G
G
R
V
L
N
V
V
G
L
G
R
D
L
K
E
A
L
E
R
A
Y
A
Y
I
P
Q
V
G
F
P
G
A
V
Y
R
R
D
I
G
R
R
A
L
-
11
PsiBlast_PDB
78.01
44%
4
- C1 -
-
2QK4
3
PUR2_HUMAN
A:
[26-448]
-
R
V
L
I
I
G
S
-
G
G
-
R
-
E
H
T
L
-
A
W
K
L
A
Q
S
H
H
V
K
Q
-
V
L
V
A
P
-
G
-
N
-
A
G
-
T
---
A
-
C
S
E
-
K
I
-
S
N
T
A
I
S
I
S
D
H
T
A
L
A
Q
F
C
K
E
K
K
I
E
F
V
V
V
G
P
E
A
P
L
A
A
G
I
V
G
N
L
R
S
A
G
V
Q
C
F
G
P
T
A
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
P
A
L
V
V
K
A
S
G
L
---
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
V
Q
E
I
M
Q
E
-------
E
T
I
V
I
E
E
L
L
D
G
E
E
V
S
C
L
C
F
T
D
G
K
T
V
A
P
M
P
P
A
Q
D
H
K
R
L
L
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
P
A
P
Q
V
S
-
N
D
-
L
L
L
K
I
K
D
-
T
-----
V
-
L
Q
R
T
V
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
I
M
L
T
K
-
N
G
-
P
K
V
L
E
F
N
C
R
F
G
D
P
E
C
Q
V
I
L
P
L
L
K
S
D
L
Y
E
V
I
Q
S
T
L
D
G
L
--
L
C
T
-
S
-
L
P
V
W
-
L
E
N
H
T
A
L
T
V
V
M
A
---
S
K
G
Y
P
G
D
Y
T
K
-----
G
---
V
---
E
I
--
T
G
----
F
----
P
---
E
A
----
Q
A
L
G
L
E
V
-----------
F
H
A
G
T
A
L
-
K
N
G
K
-
V
V
T
H
G
G
R
V
L
A
V
T
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
G
L
A
A
I
K
F
E
G
A
I
Y
R
K
D
I
G
F
R
A
I
-
21
PsiBlast_CBE
77.21
47%
-63
- C1 -
-
5VEV
8
?
B:
[9-429]
M
K
L
L
V
I
G
N
-
G
G
-
R
-
E
H
A
L
-
A
W
K
L
A
Q
S
P
K
V
E
T
-
V
F
V
A
P
-
G
-
N
-
A
G
-
T
---
A
-
I
-
E
-
S
--
K
L
Q
N
I
A
L
T
A
Y
Q
D
L
I
E
F
C
R
K
E
N
I
V
F
T
V
V
G
P
E
A
P
L
A
A
G
I
V
D
D
F
R
A
A
G
L
K
I
F
G
P
T
Q
Y
A
A
Q
L
E
S
S
K
D
F
A
K
A
F
M
V
K
Y
N
I
P
T
A
Q
Y
Q
T
F
E
N
A
D
A
A
H
D
Y
V
N
Q
K
G
A
P
-
I
V
I
K
A
--------
V
I
V
A
M
T
L
D
E
A
H
A
A
I
D
D
M
L
---------
E
R
V
V
I
E
D
F
L
Q
G
E
E
A
S
F
I
V
M
V
D
G
N
H
V
L
P
M
A
T
S
Q
D
H
K
R
L
L
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
A
P
V
V
T
-
P
A
-
V
Y
E
R
A
M
N
-
E
-----
I
-
I
L
P
T
V
A
G
M
K
A
E
G
H
E
F
T
G
F
L
Y
A
G
L
M
I
D
Q
-
S
G
A
P
Y
T
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
S
R
L
N
S
D
L
A
D
L
V
E
A
A
I
D
G
R
--
L
D
S
-
V
-
K
A
E
W
-
N
P
Q
-
T
A
V
G
V
V
L
A
---
A
Q
N
Y
P
------------------
E
T
--
P
K
----
K
---------
G
----
D
V
I
---
S
GLDDVNRI
G
K
V
F
H
A
G
T
T
V
N
E
K
G
D
-
V
L
T
N
G
G
R
I
L
C
V
V
G
L
G
D
D
V
A
Q
A
K
A
K
A
Y
G
A
L
E
K
I
S
F
D
G
M
Q
Y
R
K
D
I
A
D
K
A
I
-
13
PsiBlast_PDB
75.18
39%
-11
- C1 -
-
3LP8
-
?
A:
[22-440]
M
N
V
L
V
I
G
S
-
G
G
-
R
-
E
H
S
M
-
L
H
H
I
R
K
S
T
L
L
N
K
-
L
F
I
A
P
-
G
-
R
-
E
G
-
M
---
S
-----
G
L
A
D
I
I
D
I
D
I
N
S
T
I
E
V
I
Q
V
C
K
K
E
K
I
E
L
V
V
I
G
P
E
T
P
L
M
N
G
L
S
D
A
L
T
E
E
G
I
L
V
F
G
P
S
K
A
A
A
R
L
E
S
S
K
G
F
T
K
E
L
C
M
R
Y
G
I
P
T
A
K
Y
G
Y
F
V
D
T
N
S
A
Y
K
F
I
D
K
H
K
L
P
-
L
V
V
K
A
D
G
L
A
Q
G
K
G
T
V
I
C
H
T
H
E
E
A
Y
N
A
V
D
A
M
L
V
H
H
K
F
G
E
A
G
C
A
I
I
I
E
E
F
L
E
G
K
E
I
S
F
F
T
L
V
D
G
S
N
P
V
I
L
G
V
A
Q
D
Y
K
T
I
G
D
N
N
K
G
P
N
T
G
G
M
G
S
Y
S
K
P
N
I
I
T
-
Q
E
-
M
E
H
I
I
I
Q
-
K
-----
I
-
I
Y
P
T
I
K
A
M
F
N
M
N
I
Q
F
R
G
L
L
F
A
G
I
I
I
K
K
-
N
E
-
P
K
L
L
E
Y
N
V
R
F
G
D
P
E
T
Q
S
I
L
P
R
L
N
S
D
F
L
K
L
L
S
L
T
A
K
G
K
--
L
G
N
E
S
-
V
--
E
-
L
S
K
K
A
A
L
C
V
V
V
A
---
S
R
G
Y
P
G
E
Y
K
K
N
S
I
I
N
G
---
I
---
E
N
--
I
E
----
K
----
L
---
P
-----
N
V
Q
---
L
-----------
L
H
A
G
T
R
R
E
G
N
N
--
W
V
S
D
S
G
R
V
I
N
V
V
A
Q
G
E
N
L
A
S
A
K
H
Q
A
Y
A
A
L
D
L
L
D
W
P
D
G
I
Y
R
Y
D
I
G
S
C
---
46
HHSearch
74.61
45%
12
- C1 -
-
3MJF
6
PUR2_YERPE
A:
[4-427]
M
N
I
L
I
I
G
N
-
G
G
-
R
-
E
H
A
L
G
W
K
A
A
Q
S
P
--
L
A
D
K
I
Y
V
A
P
-
G
-
N
-
A
G
-
T
---
A
L
E
-
P
-
T
L
-
E
N
V
D
I
A
A
T
D
I
A
G
L
L
A
F
A
Q
S
H
D
I
G
L
T
I
V
G
P
E
A
P
L
V
I
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
A
R
H
N
I
P
S
A
E
Y
Q
N
F
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
F
G
D
A
G
H
R
I
V
V
E
E
F
L
D
G
E
E
A
S
F
I
V
M
V
D
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
V
G
D
G
D
T
G
P
N
T
G
G
M
G
A
Y
S
P
A
P
V
V
T
-
D
D
-
V
H
Q
R
V
-
M
-
D
QV
I
W
P
T
-
V
R
G
M
A
A
E
G
---
N
I
-
Y
T
G
F
L
Y
A
G
L
M
I
S
A
D
G
Q
-
P
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
L
R
M
R
S
D
L
V
E
L
C
L
A
G
T
Q
G
K
--
L
N
E
-
K
-
T
S
D
W
-
D
E
-
R
P
S
L
G
V
V
L
A
---
A
G
G
Y
P
A
D
Y
R
Q
-----
G
---
D
---
V
I
--
H
G
----
L
----
P
QQE
V
K
----
D
G
K
---
V
-----------
F
H
A
G
T
K
L
N
-
G
N
H
E
V
V
T
N
G
G
R
V
L
C
V
T
A
L
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
Q
W
E
G
V
F
C
R
K
D
I
G
Y
R
A
I
-
39
HHSearch
74.56
46%
40
- C1 -
-
2YW2
1
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
-
G
G
R
E
-
H
A
I
A
-
W
K
V
A
Q
S
P
--
L
V
K
-
E
L
Y
V
A
-
K
-
G
N
A
G
-
I
---
W
-
E
-
I
-
A
K
-
R
V
-
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
T
P
V
I
N
-
E
E
-
V
E
K
R
I
-
R
E
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
E
G
K
--
D
V
H
-
I
-
K
--
E
-
D
E
-
R
Y
A
L
D
V
V
L
A
S
RG
Y
P
E
K
P
E
T
G
K
--------------
I
I
--
H
G
----
L
D
Y
L
K
S
---
M
E
----
D
V
V
---
V
-----------
F
H
A
G
-
T
K
K
-
E
G
N
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
38
HHSearch
74.04
49%
15
- C1 -
-
2XCL
1
PUR2_BACSU
A:
[1-418]
M
N
V
L
I
I
G
K
G
G
R
-
E
-
H
T
L
A
-
W
K
A
A
Q
S
S
--
L
V
E
-
N
V
F
A
A
-
P
G
N
-
D
G
-
M
-----
A
-
A
-
S
A
-
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
E
E
T
-
V
R
H
A
V
-
E
-
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
D
D
K
--
E
V
D
-
L
-
R
--
W
-
K
D
-
T
A
A
V
-
S
V
V
L
---
A
--
S
E
G
Y
P
E
--------------
S
Y
--
A
K
----
G
TPIG
S
---
L
A
AETE
Q
V
V
---
V
-----------
F
H
A
G
T
K
A
E
--
G
G
E
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
37
HHSearch
73.65
49%
19
- C1 -
-
2XD4
1
PUR2_BACSU
A:
[1-418]
M
N
V
L
I
I
G
K
G
G
R
-
E
-
H
T
L
A
-
W
K
A
A
Q
S
S
--
L
V
E
-
N
V
F
A
A
-
P
G
N
-
D
G
-
M
-----
A
-
A
-
S
A
-
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
P
V
P
Q
I
S
E
E
T
-
V
R
H
A
V
-
E
-
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
D
D
K
--
E
V
D
-
L
-
R
--
W
-
K
D
-
T
A
A
V
-
S
V
V
L
---
A
--
S
E
G
Y
P
E
--------------
S
Y
--
A
K
----
G
TPIG
S
---
L
A
AETE
Q
V
V
---
V
-----------
F
H
A
G
T
K
A
E
--
G
G
E
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
43
HHSearch
72.32
42%
39
* C1 *
-
2QK4
3
PUR2_HUMAN
A:
[25-448]
A
R
V
L
I
I
G
S
-
G
G
-
R
-
E
H
T
L
A
W
K
L
A
Q
S
H
--
H
V
K
-
Q
V
L
V
A
-
P
-
G
-
N
A
G
T
ACS
E
-
K
-
I
-
S
N
-
T
A
--
I
S
I
S
D
H
T
A
L
A
Q
F
C
K
E
K
K
I
E
F
V
V
V
G
P
E
A
P
L
A
A
G
I
V
G
N
L
R
S
A
G
V
Q
C
F
G
P
T
A
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
P
A
L
V
V
K
A
S
G
L
---
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
V
Q
E
I
M
Q
E
-------
E
T
I
V
I
E
E
L
L
D
G
E
E
V
S
C
L
C
F
T
D
G
K
T
V
A
P
M
P
P
A
Q
D
H
K
R
L
L
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
P
A
P
Q
V
S
-
N
D
-
L
L
L
K
I
-
K
-
D
-----
T
V
L
Q
R
T
V
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
I
M
L
T
K
-
N
G
-
P
K
V
L
E
F
N
C
R
F
G
D
P
E
C
Q
V
I
L
P
L
L
K
S
D
L
Y
E
V
I
Q
S
T
L
D
G
L
--
L
C
T
-
S
L
P
--
V
W
L
E
N
H
T
A
L
T
V
V
M
A
---
S
K
G
Y
P
G
D
Y
T
K
-----
G
---
V
---
E
I
--
T
G
----
F
----
P
E
A
Q
A
L
----
G
L
E
---
V
-----------
F
H
A
G
T
A
L
K
-
N
G
K
V
-
V
T
H
G
G
R
V
L
A
V
T
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
G
L
A
A
I
K
F
E
G
A
I
Y
R
K
D
I
G
F
R
A
I
-