@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0057: (2017-12-14 )
MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTENQPTIHTVSDSPQSSENRTEETPKAELQPEAPKTVETETPATDKVASLPKTEEKPQEEVSSTPSDKAEVVTPTSAEKETANKKEEEASPKKEEAKEVDSKESNTDKTDKDKPAKKDEAKAEADKPETETGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTDLHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTDLINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKKSARTVDLDNEQAVAFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYEKFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVASSKLLAEKGHQILNTNDAWCYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIPIIGGMVAAWADTPSARYSPSHLFKLMRHFANANAEYFAADYESAEQALNEVPKDLNRYTAESVAAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEAQKEEEAKREVEKLAKNKVISIDAGRKYFTLDQLKRIVDKASELGYSDVHLLLGNDGLRFLLNDMTITANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSPGHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKIFNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYEDKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYVIGNHKQDEAYPLSKAVENSGKVPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFADHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTLVANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAGQENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGSPVTHKGDESGLAPTTEVKPRLDIQEEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADGKEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPAEESKALPQDPAPVVTEKKLPETGTHDSAELVVAGLMSTLAAYGLTKRKED
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500-........510.......520.----......530.......540...--....550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
H
E
K
Q
Q
R
F
S
I
R
K
YAV
G
A
A
S
V
L
I
G
F
A
F
Q
A
Q
T
VAADGVTPTTTENQ
P
T
I
H
TVSDSPQSSENRTEETPKAELQPEAPKTVETETPATDKVASLPKTEEK
P
Q
E
E
VSSTPSDK
A
E
V
VTPTSAEKETANKKEEEASP
K
K
E
E
A
K
E
VDSKESNTDKTDKDKPAKKDEAKAEADKPETETGK
E
R
A
A
T
V
N
E
K
L
A
K
K
K
I
V
S
IDAGRKYF
S
P
E
Q
L
K
E
I
I
D
K
A
KHYGY
T
D
L
H
L
L
VGNDG
L
R
F
M
L
DD
M
S
I
TANGKTY
A
S
D
D
V
K
R
A
I
E
KGTNDYYNDPNGNHL
T
E
S
Q
M
T
D
L
I
N
Y
A
K
DKG
I
G
LIPTVNSPG
H
M
D
A
I
L
N
A
M
K
ELGIQNPNFSYFGKKSA
R
T
VDLDN
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
AKK
T
E
I
F
N
I
G
L
D
EYANDATDAKG
W
S
V
L
Q
ADKYYPNEGYPV
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
SHGLK
P
M
AFND
G
I
Y
YNSDTSFGSFDK
D
I
I
V
S
M
WTGGWGGYDV
A
S
S
K
L
L
A
E
KG
H
Q
ILNTND
A
W
C
Y
V
L
GRNADGQGWY
N
L
D
Q
GLNGIKNTPITSVPK--TEGADIPIIGG
M
V
AAWADTPSA----RY
S
P
S
H
L
F
K
L
M
R
H
F
ANANA
E
Y
F
--A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
A
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
NNLTLTP
E
A
Q
K
E
E
E
A
K
R
E
V
E
K
L
AKN
K
V
I
S
IDAG
R
K
Y
F
T
L
D
Q
L
K
R
I
V
D
K
A
S
ELGY
S
D
V
H
L
L
LGND
G
L
R
F
L
LND
M
T
I
TANGKTY
A
S
D
D
V
K
K
A
I
I
EGT
K
A
Y
YDDPNGTA
L
T
Q
A
E
V
T
E
L
I
E
Y
A
KSKDI
G
L
IPAINSPG
H
M
D
A
M
L
V
A
M
E
K
LGIKN
P
Q
A
H
F
D
K
V
S
K
T
T
MDLK
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
FAGK
T
K
I
F
NFGTDEYANDATSAQ
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
ERGLQPMAFNDGFYYEDKDDVQF
D
K
D
V
L
I
S
Y
WSK
G
W
WGYNLA
S
P
Q
Y
L
A
SKG
Y
K
F
LNTNG
D
W
Y
Y
V
IGNHKQDEAYP
L
S
K
A
VENSGKV
P
F
N
Q
LASTKYPEVDLP
T
V
G
S
M
L
S
I
WADRPSAE
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
DHN
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
KIPTNLEGY
S
K
E
S
L
E
A
L
D
A
A
K
T
A
LNYNLNRN
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
QGLKPAATHSGSLD
E
N
E
VAANVETR
P
E
L
I
T
R
T
EEI
P
F
E
V
I
KKENPNLPAGQE
N
I
I
TAGVKGE
R
T
H
Y
I
S
V
L
TENGK
T
T
E
T
V
L
D
S
Q
V
T
K
E
V
I
N
Q
V
V
EVGSPVTHKGDESGLAPTTEVKPRLDIQEEEIP
F
T
T
VTREN
P
L
L
LKGK
T
Q
V
I
TKGVNGHRS
N
F
Y
S
VSTSAD
G
K
E
V
K
T
L
V
N
S
V
V
A
Q
E
A
V
T
Q
I
V
E
V
G
T
M
V
T
HVGDENGQAAIAEEKPKLEIPSQPAPSTAPA
E
E
SKALPQDPAPVVTEKKLPETGTH
D
S
A
E
L
V
V
A
G
L
M
S
T
L
A
A
YGLTKRKED
1
PsiBlast_PDB
95.31
98%
-73
- C3 -
-
3RPM
2
?
A:
[6-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
C
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
H
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
A
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
P
E
A
Q
K
E
E
E
A
K
R
E
V
E
K
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.15
99%
-76
- C3 -
-
4AZ5
5
STRH_STRPN
A:
[1-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.05
99%
-76
- C3 -
-
4AZ7
7
STRH_STRPN
A:
[1-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.91
98%
-75
- C3 -
-
2YLL
3
STRH_STRPN
A:
[19-454]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
94.88
99%
-75
- C3 -
-
4AZ6
5
STRH_STRPN
A:
[3-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
94.58
99%
-75
- C3 -
-
2YL8
4
STRH_STRPN
A:
[1-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
Q
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.37
99%
-74
- C3 -
-
2YL6
11
STRH_STRPN
A:
[1-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
L
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
92.54
96%
-76
- C3 -
-
4AZC
1
STRH_STRPN
B:
[7-421]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
T
N
L
E
G
Y
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
G
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
92.44
95%
-81
- C3 -
-
2YL9
7
D:
[20-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
Q
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.39
95%
-77
- C3 -
-
4AZC
1
D:
[3-417]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
T
--
E
G
Y
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
92.34
95%
-83
- C3 -
-
2YL9
16
STRH_STRPN
A:
[20-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
Q
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
92.16
95%
-77
- C3 -
-
2YLA
12
STRH_STRPN
B:
[3-417]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
Q
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
T
N
L
E
G
Y
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
90.84
95%
-77
- C3 -
-
4AZH
6
STRH_STRPN
A:
[4-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
T
N
L
E
G
Y
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
G
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
90.83
95%
-81
- C3 -
-
2YL5
4
D:
[3-417]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
-------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.81
95%
-78
- C3 -
-
4AZG
6
STRH_STRPN
A:
[4-418]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
-------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
90.66
95%
-76
- C3 -
-
4AZC
4
STRH_STRPN
C:
[3-418]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
T
N
--
G
Y
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
90.64
95%
-80
- C3 -
-
2YLA
3
D:
[3-417]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
Q
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
-------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
90.55
95%
-82
- C3 -
-
2YL9
4
STRH_STRPN
B:
[20-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
Q
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
-------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
90.53
95%
-77
- C3 -
-
2YLA
6
STRH_STRPN
C:
[3-417]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
Q
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
-------
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
90.24
95%
-77
- C3 -
-
4AZH
3
STRH_STRPN
B:
[4-420]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
Y
Y
L
K
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
E
D
G
G
G
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
T
K
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
K
D
Y
F
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
P
T
N
L
E
G
Y
S
K
E
S
L
E
A
L
D
A
A
K
T
A
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.08
98%
-65
- C3 -
-
4AZB
6
STRH_STRPN
A:
[1-425]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
L
A
K
K
K
I
V
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
G
G
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
----
R
Y
S
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
-----------------
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
87.93
93%
-59
- C3 -
-
2YL6
11
STRH_STRPN
A:
[2-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
A
K
K
K
I
V
-
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
RYS
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
----
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
87.50
93%
-60
- C3 -
-
4AZ6
5
STRH_STRPN
A:
[2-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
N
E
K
L
A
K
K
K
I
V
-
S
I
D
A
G
R
K
Y
F
S
P
E
Q
L
K
E
I
I
D
K
A
K
H
Y
G
Y
T
D
L
H
L
L
V
G
N
D
G
L
R
F
M
L
D
D
M
S
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
R
A
I
E
K
G
T
N
D
Y
Y
N
D
P
N
G
N
H
L
T
E
S
Q
M
T
D
L
I
N
Y
A
K
D
K
G
I
G
L
I
P
T
V
N
S
P
G
H
M
D
A
I
L
N
A
M
K
E
L
G
I
Q
N
P
N
F
S
Y
F
G
K
K
S
A
R
T
V
D
L
D
N
E
Q
A
V
A
F
T
K
A
L
I
D
K
Y
A
A
Y
F
A
K
K
T
E
I
F
N
I
G
L
D
E
Y
A
N
D
A
T
D
A
K
G
W
S
V
L
Q
A
D
K
Y
Y
P
N
E
G
Y
P
V
K
G
Y
E
K
F
I
A
Y
A
N
D
L
A
R
I
V
K
S
H
G
L
K
P
M
A
F
N
D
G
I
Y
Y
N
S
D
T
S
F
G
S
F
D
K
D
I
I
V
S
M
W
T
G
G
W
G
G
Y
D
V
A
S
S
K
L
L
A
E
K
G
H
Q
I
L
N
T
N
D
A
W
Y
Y
V
L
G
R
N
A
D
G
Q
G
W
Y
N
L
D
Q
G
L
N
G
I
K
N
T
P
I
T
S
V
P
K
--
T
E
G
A
D
I
P
I
I
G
G
M
V
A
A
W
A
D
T
P
S
A
RYS
P
S
R
L
F
K
L
M
R
H
F
A
N
A
N
A
E
Y
F
--
A
A
----
D
Y
E
S
A
E
Q
A
L
N
E
V
P
K
D
L
N
R
Y
T
A
E
S
V
T
A
V
K
E
A
E
K
A
I
R
S
L
D
S
N
L
S
R
A
Q
Q
D
T
I
D
Q
A
I
A
K
L
Q
E
T
V
N
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
78.05
51%
-53
* C3 *
-
4AZI
6
B:
[3-417]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
K
L
A
K
N
K
V
I
-
S
I
D
A
G
R
K
Y
F
T
L
N
Q
L
K
R
I
V
D
K
A
S
E
L
G
Y
S
D
V
H
L
L
L
G
N
D
G
L
R
F
L
L
D
D
M
T
I
T
A
N
G
K
T
Y
A
S
D
D
V
K
K
A
I
I
E
G
T
K
A
Y
Y
D
D
P
N
G
T
A
L
T
Q
A
E
V
T
E
L
I
E
Y
A
K
S
K
D
I
G
L
I
P
A
I
N
S
P
G
H
M
D
A
M
L
V
A
M
E
K
L
G
I
K
N
P
Q
A
-
H
F
D
K
V
S
K
T
T
M
D
L
K
N
E
E
A
M
N
F
V
K
A
L
I
G
K
Y
M
D
F
F
A
G
K
T
K
I
F
N
F
G
T
D
E
Y
A
N
D
A
T
S
A
Q
G
W
--------
Y
Y
L
K
--
W
Y
Q
L
Y
G
K
F
A
E
Y
A
N
T
L
A
A
M
A
K
E
R
G
L
Q
P
M
A
F
N
D
G
F
Y
Y
E
D
K
-
D
D
V
Q
F
D
K
D
V
L
I
S
Y
W
S
K
G
W
W
G
Y
N
L
A
S
P
Q
Y
L
A
S
K
G
Y
K
F
L
N
T
N
G
D
W
Y
Y
I
L
G
Q
K
P
-
E
D
G
W
Y
F
L
K
K
A
I
E
N
T
G
K
T
P
F
N
Q
L
A
S
TK
Y
P
E
V
D
L
P
T
V
G
S
M
L
S
I
W
A
D
R
P
S
A
----
E
Y
K
E
E
E
I
F
E
L
M
T
A
F
A
D
H
N
--
K
D
YF
R
A
N
Y
N
A
L
R
E
E
L
A
K
I
---------
E
S
L
E
A
L
D
A
A
K
T
A
---
L
N
Y
N
L
N
R
N
K
Q
A
E
L
D
T
L
V
A
N
L
K
A
A
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------