@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0064: (2017-12-14 )
MLHYTKEDLLELGAEITTREIYQQPDVWREAFEFYQAKREEIAAFLQEIADKHDYIKVILTGAGTSAYVGDTLLPYFKEVYDERKWNFNAIATTDIVANPATYLKKDVATVLVSFARSGNSPESVATVDLAKSLVDELYQVTITCATDGKLALQAHGDDRNLLLLQPAVSNDAGFAMTSSFTSMMLTALLVFDPTEFAVKSERFEVVSSLARKVLDKAEDVKELVDLDFNRVIYLGAGPFFGLAHEAQLKILELTAGQVATMYESPVGFRHGPKSLINDNTVVLVFGTTTDYTRKYDLDLVREVAGDQIARRVVLLSDQAFGLENVKEVALGCGGVLNDIYRVFPYIVYAQLFALLTSLKVENKPDTPSPTGTVNRVVQGVIIHEYQK
Atome Classification :
(20 SA)
.........10........20........30......------.----.40-----..---.......50.........60........70........80.........90........100........110.......120.......130.-.....-.140.......150.......160....--...-170-.......180.......190.....-------.---------.---200.......210--....-..-..220...--.---...230.......240...-....250....--...260....-....270.......280.......290.......300..-.....310.......320.-.--.....330...----.----..------.340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLHY
T
K
E
D
L
L
E
LGAE
I
T
T
R
E
I
YQQ
P
D
V
W
R
E
A
F
E
F
Y
Q
A
------
K
----
R
E
------
E
I
---
A
A
F
L
Q
E
I
A-DKH
D
Y
I
K
V
I
L
TGAGTSAYVG
D
T
L
L
P
Y
F
K
E
V
-
Y
DERKWNF
N
A
I
A
T
TDIVA
N
P
A
-
T
Y
L
K
K
D
V
A
T
V
L
V
S
F
A
RSGNSPES
V
A
T
V
D
L
A
K
S
-
L
V
D
E
L
-
Y
Q
V
T
I
T
C
ATD
G
K
L
A
L
Q
AHGDDR
N
L
L
L
LQ--PAV-SND-AG
F
A
M
T
S
S
F
T
S
M
M
L
T
A
L
L
V
FDPTEF-------
A
---------
V
---
K
S
E
R
F
E
V
V
S
S
L
A
---
R
K
V
L
-
D
K
-
A
E
D
V
K
E
L
V
--D---LDFN
R
V
I
Y
LGAGPFFGLAH-E
A
Q
L
K
I
L
E
LTA--GQ
V
A
-
T
M
YES-PVGFRHG
P
K
S
LINDN
T
V
V
L
V
F
GTTTDYTRKY
D
L
D
L
V
R
E
V
-
A
G
D
Q
I
A
R
R
V
V
L
LSDQAF
G
L
-
E
--
N
V
K
E
V
A
LGC
G
G
----
V
----
L
N
------
D
I
Y
R
V
F
P
Y
I
V
Y
A
Q
L
F
A
L
L
T
S
LKVENKPDTPSPT
G
T
V
N
R
V
V
Q
G
V
I
I
HEYQK
1
PsiBlast_PDB
97.90
98%
-113
- C2 -
-
3I0Z
10
?
A:
[3-388]
-
L
H
Y
T
K
E
D
L
L
E
L
G
A
E
I
T
T
R
E
I
Y
Q
Q
P
D
V
W
R
E
A
F
E
F
Y
Q
A
------
K
----
R
E
------
E
I
---
A
A
F
L
Q
E
I
A
-
D
K
H
D
Y
I
K
V
I
L
T
G
A
G
T
S
A
Y
V
G
D
T
L
L
P
Y
F
K
E
V
-
Y
D
E
R
K
W
N
F
N
A
I
A
T
T
D
I
V
A
N
P
A
-
T
Y
L
K
K
D
V
A
T
V
L
V
S
F
A
R
S
G
N
S
P
E
S
L
A
T
V
D
L
A
K
S
-
L
V
D
E
L
-
Y
Q
V
T
I
T
C
A
A
D
G
K
L
A
L
Q
A
H
G
D
D
R
N
L
L
L
L
Q
--
P
A
V
-
S
N
D
-
A
G
F
A
M
T
S
S
F
T
S
M
M
L
T
T
L
L
V
F
D
P
T
E
F
-------
A
---------
V
---
K
S
E
R
F
E
V
V
S
S
L
A
---
R
K
V
L
-
D
K
-
A
E
D
V
K
E
L
V
--
D
---
L
D
F
N
R
V
I
Y
L
G
A
G
P
F
F
G
L
A
H
-
E
A
Q
L
K
I
L
E
L
T
A
--
G
Q
V
A
-
T
M
Y
E
S
-
P
V
G
F
R
H
G
P
K
S
L
I
N
D
N
T
V
V
L
V
F
G
T
T
T
D
Y
T
R
K
Y
D
L
D
L
V
R
E
V
-
A
G
D
Q
I
A
R
R
V
V
L
L
S
D
Q
A
F
G
L
-
E
--
N
V
K
E
V
A
L
G
C
G
G
----
V
----
L
N
------
D
I
Y
R
V
F
P
Y
I
V
Y
A
Q
L
F
A
L
L
T
S
L
K
V
E
N
K
P
D
T
P
S
P
T
G
T
V
N
R
V
V
Q
G
V
I
I
H
E
Y
Q
-
21
HHSearch
90.22
98%
-62
- C2 -
-
3I0Z
10
?
A:
[2-388]
M
L
H
Y
T
K
E
D
L
L
E
L
G
A
E
I
T
T
R
E
I
Y
Q
Q
P
D
V
W
R
E
A
F
E
F
Y
Q
A
------
K
----
R
E
------
E
I
---
A
A
F
L
Q
E
I
A
D
K
H
-
D
Y
I
K
V
I
L
T
G
A
G
T
S
A
Y
V
G
D
T
L
L
P
Y
F
K
E
V
-
Y
D
E
R
K
W
N
F
N
A
I
A
T
T
D
I
V
A
N
P
A
-
T
Y
L
K
K
D
V
A
T
V
L
V
S
F
A
R
S
G
N
S
P
E
S
L
A
T
V
D
L
A
K
S
-
L
V
D
E
L
-
Y
Q
V
T
I
T
C
A
A
D
G
K
L
A
L
Q
A
H
G
D
D
--
R
N
L
L
L
L
Q
P
A
V
-
S
N
D
-
A
G
F
A
M
T
S
S
F
T
S
M
M
L
T
T
L
L
V
F
D
P
T
E
F
-------
A
---------
V
---
K
S
E
R
F
E
V
V
S
S
L
A
---
R
K
V
L
-
D
K
-
A
E
D
V
K
E
L
V
--
D
---
L
D
F
N
R
V
I
Y
L
G
A
G
P
F
F
G
L
A
H
-
E
A
Q
L
K
I
L
E
L
T
A
--
G
Q
V
A
-
T
M
Y
E
S
-
P
V
G
F
R
H
G
P
K
S
L
I
N
D
N
T
V
V
L
V
F
G
T
T
T
D
Y
T
R
K
Y
D
L
D
L
V
R
E
V
-
A
G
D
Q
I
A
R
R
V
V
L
L
S
D
Q
A
F
G
L
-
E
--
N
V
K
E
V
A
L
G
C
G
G
----
V
----
L
N
------
D
I
Y
R
V
F
P
Y
I
V
Y
A
Q
L
F
A
L
L
T
S
L
K
V
E
N
K
P
D
T
P
S
P
T
G
T
V
N
R
V
V
Q
G
V
I
I
H
E
Y
Q
-
2
PsiBlast_PDB
76.21
41%
-86
- C2 -
-
3ODP
2
?
A:
[5-392]
L
L
G
Y
S
E
D
Y
L
K
E
R
K
G
Y
I
T
A
K
E
I
C
N
Q
P
K
L
W
R
E
T
Y
E
I
I
L
S
------
Q
----
R
E
------
K
L
---
K
S
F
L
D
N
F
A
-
K
K
P
N
-
A
K
I
V
I
T
G
A
G
S
S
A
F
V
G
N
S
V
V
S
Y
L
N
A
----
K
E
N
I
K
I
E
A
I
A
T
T
D
I
V
S
H
P
F
-
Y
Y
L
K
K
D
E
P
T
L
L
I
S
C
A
R
S
G
N
S
P
E
S
T
A
A
V
T
L
A
E
K
-
I
V
D
D
I
-
S
H
L
I
I
T
C
N
S
E
G
K
L
A
L
H
A
K
R
N
Y
N
S
F
L
L
L
M
--
P
E
E
-
S
N
D
-
K
G
F
A
M
T
G
S
F
S
T
M
L
L
S
C
L
L
I
F
N
L
D
K
L
-------
E
---------
S
---
I
G
K
Q
I
E
S
I
S
M
Q
G
---
E
K
V
L
V
N
N
-
V
E
L
M
K
K
I
V
--
G
---
E
K
F
K
R
T
V
Y
L
G
A
A
N
A
F
G
L
A
K
-
E
S
A
L
K
V
L
E
L
T
A
--
G
K
I
A
-
T
L
Y
D
T
-
P
L
G
F
R
H
G
P
K
S
I
I
D
D
E
T
L
I
V
I
F
F
S
N
D
T
Y
A
R
E
Y
E
Y
D
L
L
K
E
V
-
Y
S
Q
N
G
N
H
K
V
L
A
I
S
E
Y
E
D
K
L
I
E
--
D
N
S
D
Y
F
I
A
I
N
K
E
E
Q
E
Y
----
E
D
------
D
S
F
L
S
L
D
Y
L
L
N
A
Q
M
Y
A
F
I
N
S
M
E
L
G
I
G
P
D
N
P
C
P
T
G
E
V
N
R
V
V
K
G
V
I
I
H
D
Y
--
22
HHSearch
74.89
43%
-76
- C2 -
-
3ODP
2
?
A:
[6-392]
-
L
G
Y
S
E
D
Y
L
K
E
R
K
G
Y
I
T
A
K
E
I
C
N
Q
P
K
L
W
R
E
T
Y
E
I
I
L
S
------
Q
----
R
E
------
K
L
---
K
S
F
L
D
N
F
A
-
K
K
-
P
N
A
K
I
V
I
T
G
A
G
S
S
A
F
V
G
N
S
V
V
S
Y
L
N
A
K
-
E
N
---
I
K
I
E
A
I
A
T
T
D
I
V
S
H
P
F
-
Y
Y
L
K
K
D
E
P
T
L
L
I
S
C
A
R
S
G
N
S
P
E
S
T
A
A
V
T
L
A
E
K
-
I
V
D
D
I
-
S
H
L
I
I
T
C
N
S
E
G
K
L
A
L
H
A
K
R
N
Y
N
S
F
L
L
L
M
--
P
E
E
-
S
N
D
-
K
G
F
A
M
T
G
S
F
S
T
M
L
L
S
C
L
L
I
F
N
L
D
K
L
-------
E
---------
S
---
I
G
K
Q
I
E
S
I
S
M
Q
G
---
E
K
V
L
-
V
N
N
V
E
L
M
K
K
I
V
--
G
---
E
K
F
K
R
T
V
Y
L
G
A
A
N
A
F
G
L
A
K
-
E
S
A
L
K
V
L
E
L
T
A
--
G
-
K
I
-
A
T
L
Y
D
T
P
L
G
F
R
H
G
P
K
S
I
I
D
D
E
T
L
I
V
I
F
F
S
N
D
T
Y
A
R
E
Y
E
Y
D
L
L
K
E
V
-
Y
S
Q
N
G
N
H
K
V
L
A
I
S
E
Y
E
D
K
L
I
E
--
D
N
S
D
Y
F
I
A
I
N
K
----
E
E
Q
E
Y
E
D
------
D
S
F
L
S
L
D
Y
L
L
N
A
Q
M
Y
A
F
I
N
S
M
E
L
G
I
G
P
D
N
P
C
P
T
G
E
V
N
R
V
V
K
G
V
I
I
H
D
Y
--
24
HHSearch
61.42
43%
-129
- C2 -
-
3C3J
-
AGAS_ECOLI
A:
[5-383]
-----
Y
T
P
A
A
A
A
T
G
T
W
T
E
E
E
I
R
H
Q
P
R
A
W
I
R
S
L
T
N
I
D
A
------
L
----
R
S
------
A
L
---
N
N
F
L
E
P
L
L
-
R
K
-
E
N
L
R
I
I
L
T
G
A
G
T
S
A
F
I
G
D
I
I
A
P
W
L
A
S
H
-
T
G
---
K
N
F
S
A
V
P
T
T
D
L
V
T
N
P
M
-
D
Y
L
N
P
A
H
P
L
L
L
I
S
F
G
R
S
G
N
S
P
E
S
V
A
A
V
E
L
A
N
Q
-
F
V
P
E
C
-
Y
H
L
P
I
T
C
N
E
A
G
A
L
Y
Q
N
A
I
N
S
D
N
A
F
A
L
L
M
--
P
A
E
-
T
H
D
-
R
G
F
A
M
T
S
S
I
T
T
M
M
A
S
C
L
A
V
F
A
P
-
E
T
-------
I
---------
N
----
S
Q
T
F
R
D
V
A
D
R
C
---
Q
A
I
L
-
T
S
L
G
D
F
S
E
G
V
F
--
G
Y--
A
P
W
K
R
I
V
Y
L
G
S
G
G
L
Q
G
A
A
R
-
E
S
A
L
K
V
L
E
L
T
A
--
G
-
K
L
A
A
F
Y
D
S
-
P
T
G
F
R
H
G
P
K
S
L
V
D
D
E
T
L
V
V
V
F
V
S
S
H
P
Y
T
R
Q
Y
D
L
D
L
L
A
E
L
-
R
R
D
N
Q
A
M
R
V
I
A
I
A
A
E
S
S
D
I
-
V
---
A
A
G
P
H
I
I
L
P
P
----
S
RH--
F
I
------
D
V
E
Q
A
F
C
F
L
M
Y
A
Q
T
F
A
L
M
Q
S
L
H
M
G
N
T
P
D
T
P
-----------
G
V
I
I
H
P
W
Q
-
3
PsiBlast_PDB
58.96
43%
-129
- C2 -
-
3C3J
-
AGAS_ECOLI
A:
[16-383]
----------------
T
E
E
E
I
R
H
Q
P
R
A
W
I
R
S
L
T
N
I
D
A
------
L
----
R
S
------
A
L
---
N
N
F
L
E
P
L
L
-
R
K
E
N
-
L
R
I
I
L
T
G
A
G
T
S
A
F
I
G
D
I
I
A
P
W
L
A
S
H
-
T
G
K
---
N
F
S
A
V
P
T
T
D
L
V
T
N
P
M
-
D
Y
L
N
P
A
H
P
L
L
L
I
S
F
G
R
S
G
N
S
P
E
S
V
A
A
V
E
L
A
N
Q
-
F
V
P
E
C
-
Y
H
L
P
I
T
C
N
E
A
G
A
L
Y
Q
N
A
I
N
S
D
N
A
F
A
L
L
M
--
P
A
E
-
T
H
D
-
R
G
F
A
M
T
S
S
I
T
T
M
M
A
S
C
L
A
V
F
A
P
E
---------
T
---------
I
---
N
S
Q
T
F
R
D
V
A
D
R
C
---
Q
A
I
L
-
T
S
-
L
G
D
F
S
E
G
V
FG
Y
---
A
P
W
K
R
I
V
Y
L
G
S
G
G
L
Q
G
A
A
R
-
E
S
A
L
K
V
L
E
L
T
A
--
G
K
L
A
-
A
F
Y
D
S
-
P
T
G
F
R
H
G
P
K
S
L
V
D
D
E
T
L
V
V
V
F
V
S
S
H
P
Y
T
R
Q
Y
D
L
D
L
L
A
E
L
-
R
R
D
N
Q
A
M
R
V
I
-----
A
I
A
A
-
E
--
S
S
D
I
V
A
A
G
P
H
I
----
I
----
L
P
PSRHFI
D
V
E
Q
A
F
C
F
L
M
Y
A
Q
T
F
A
L
M
Q
S
L
H
M
G
N
T
P
D
T
P
-----------
G
V
I
I
H
P
W
Q
-
44
HHSearch
52.30
21%
-49
- C2 -
-
2DEC
2
?
A:
[1-324]
--------------
M
K
T
L
I
E
I
K
Q
T
P
D
G
I
I
K
A
D
K
V
F
N
K
--------------------
V
------
K
D
K
-
I
-
S
--
L
P
N
R
I
L
Y
L
G
C
G
S
S
H
F
L
S
K
L
L
A
M
V
T
N
M
H
--
G
---
G
L
G
I
A
L
P
C
S
E
F
L
Y
S
K
E
T
Y
P
I
--
G
E
V
E
L
A
V
G
I
S
R
S
G
E
T
T
E
I
L
L
A
L
E
K
I
N
------
V
-
K
K
L
G
I
T
T
-
R
E
S
S
L
T
R
M
C
D
-----
Y
S
L
V
V
--
P
A
I
--
E
E
--
S
V
V
M
T
H
S
F
T
S
F
Y
F
A
Y
L
Q
L
L
R
Y
S
Y
G
-------
L
---------
P
---
P
-
L
N
A
G
E
I
S
K
A
T
---
E
K
S
L
-
E
Y
-
E
R
Y
I
R
E
I
V
--
E
S
--
F
D
F
Q
N
I
I
F
L
G
S
G
L
L
Y
P
V
A
L
-
E
A
S
L
K
M
K
E
M
S
I
----
F
W
-
S
E
A
Y
P
-
T
F
E
V
R
H
G
F
K
A
I
A
D
E
K
T
L
V
V
L
M
V
E
E
P
---
F
E
W
H
E
K
L
V
K
E
F
-
K
N
Q
G
--
A
K
V
L
V
I
S
N
S
P
Q
D
L
-----
G
Q
D
Y
S
I
E
L
P
-----
R
----
L
S
------
K
D
A
N
P
I
P
Y
L
P
I
V
Q
L
L
S
Y
Y
K
A
V
S
R
G
L
N
P
D
N
P
R
F
L
D
K
V
V
R
------------
43
HHSearch
51.66
21%
-48
- C2 -
-
2E5F
3
?
B:
[2-324]
---------------
K
T
L
I
E
I
K
Q
T
P
D
G
I
I
K
A
D
K
V
F
N
K
--------------------
V
------
K
D
K
-
I
-
S
--
L
P
N
R
I
L
Y
L
G
C
G
S
S
H
F
L
S
K
L
L
A
M
V
T
N
M
H
--
G
---
G
L
G
I
A
L
P
C
S
E
F
L
Y
S
K
E
T
Y
P
I
--
G
E
V
E
L
A
V
G
I
S
R
S
G
E
T
T
E
I
L
L
A
L
E
K
I
N
------
V
-
K
K
L
G
I
T
T
-
R
E
S
S
L
T
R
M
C
D
-----
Y
S
L
V
V
--
P
A
I
--
E
E
--
S
V
V
M
T
H
S
F
T
S
F
Y
F
A
Y
L
Q
L
L
R
Y
S
Y
G
-------
L
---------
P
---
P
-
L
N
A
G
E
I
S
K
A
T
---
E
K
S
L
-
E
Y
-
E
R
Y
I
R
E
I
V
--
E
S
--
F
D
F
Q
N
I
I
F
L
G
S
G
L
L
Y
P
V
A
L
-
E
A
S
L
K
M
K
E
M
S
I
----
F
W
-
S
E
A
Y
P
-
T
F
E
V
R
H
G
F
K
A
I
A
D
E
K
T
L
V
V
L
M
V
E
E
P
---
F
E
W
H
E
K
L
V
K
E
F
-
K
N
Q
G
--
A
K
V
L
V
I
S
N
S
P
Q
D
L
-----
G
Q
D
Y
S
I
E
L
P
-----
R
----
L
S
------
K
D
A
N
P
I
P
Y
L
P
I
V
Q
L
L
S
Y
Y
K
A
V
S
R
G
L
N
P
D
N
P
R
F
L
D
K
V
V
R
------------
35
HHSearch
50.61
17%
-60
- C2 -
-
3G68
5
?
B:
[2-340]
--------------
M
T
I
Q
D
Y
M
L
E
T
P
V
R
M
R
E
I
I
S
N
A
D
S
------
L
-------------
F
---
N
E
V
-
K
--
R
-
T
--
N
L
K
K
I
I
I
T
G
S
G
T
S
Y
H
S
G
V
Q
V
Q
P
Y
L
Q
N
L
-
L
D
---
I
D
V
V
K
M
Y
P
F
M
I
T
E
D
T
F
-
K
F
D
--
N
E
N
T
L
V
V
G
V
S
Q
G
G
S
S
Y
S
T
Y
N
A
M
K
L
A
E
D
-
K
--
G
C
-
K
I
A
S
M
A
G
C
K
N
A
L
I
D
E
I
S
D
-----
Y
I
L
T
V
--
N
C
G
--
E
E
-
K
S
G
A
K
T
K
G
Y
Y
C
T
K
L
N
L
M
L
L
G
L
Q
I
A
R
EKGIISS
E
---------
K
---
Y
N
E
E
I
N
K
I
L
D
A
I
NRF
E
A
V
Y
-
K
L
S
K
Q
W
I
E
R
N
K
--
E
KL-
V
N
S
K
E
I
R
I
I
G
H
S
D
I
Y
G
D
T
L
-
E
A
A
L
K
L
L
E
T
M
R
----
I
P
-
V
T
G
Y
E
-
F
E
E
F
I
H
G
I
Y
N
A
I
N
S
D
S
T
I
F
I
L
D
T
G
K
E
-
P
--
R
V
T
K
M
I
D
V
L
-
S
G
W
T
--
E
N
V
F
A
I
G
R
D
V
T
E
-------
N
D
K
N
L
K
I
D
I
----
T
----
D
N
------
P
Y
Y
Q
T
F
N
F
I
V
P
I
Q
L
I
C
G
E
I
P
T
L
R
G
V
D
P
S
V
P
K
D
T
R
----------------
27
HHSearch
50.49
17%
-68
- C2 -
-
3FJ1
-
?
D:
[4-333]
-----------
Q
H
I
T
R
M
R
R
E
I
D
E
I
P
E
A
V
Q
R
L
L
D
H
G
A
Q
------
D
----
V
A
------
R
V
---
A
A
V
L
R
--
L
-
R
--
D
P
S
F
V
A
T
V
A
R
G
S
S
D
H
V
C
T
Y
L
S
Y
A
A
E
L
L
-
L
G
---
L
P
V
A
S
L
G
P
S
V
A
S
V
Y
D
A
-
R
L
R
--
L
D
R
A
L
C
L
A
V
S
Q
S
G
K
S
P
D
I
V
A
M
T
R
N
A
G
R
-
D
--
G
A
-
L
C
V
A
L
T
N
D
A
A
S
P
L
A
G
V
S
A
-----
H
T
I
D
I
--
H
A
--
G
P
E
-
L
S
V
A
A
T
K
T
F
V
T
S
A
V
A
G
L
M
L
L
A
D
W
A
E
D------
D
---------
G
---
L
R
A
A
L
G
N
L
P
E
T
L
---
A
A
A
S
-
R
I
--
D
W
-
P
E
M
R
VA
I
---
G
A
R
P
S
L
F
T
L
G
R
G
T
S
L
A
V
S
N
-
E
A
A
L
K
F
K
E
T
C
Q
----
L
H
-
A
E
S
Y
S
-
S
A
E
V
L
H
G
P
V
S
I
V
E
E
G
F
P
V
L
G
F
A
A
G
D
A
-
A
E
A
P
L
A
E
I
A
D
Q
I
-
A
A
K
G
--
A
T
V
F
A
T
T
G
R
V
T
R
--------
A
R
V
L
E
H
V
R
----
S
----
G
H
------
A
L
T
D
P
L
S
L
I
V
S
F
Y
S
M
V
E
A
F
A
S
E
R
G
I
D
P
D
A
---------------------
40
HHSearch
48.96
14%
-35
- C2 -
-
2AML
1
?
A:
[12-358]
-----------
H
M
K
P
T
M
M
T
Y
I
N
E
E
E
E
M
C
R
V
I
L
A
D
F
Q
T
------
N
----
A
E
------
K
L
------
E
S
L
-
V
-
K
N
-
G
A
K
E
W
L
I
L
A
T
G
S
S
L
N
A
A
Q
S
A
K
Y
Y
I
E
N
L
-
A
D
---
V
R
I
T
I
E
E
P
F
N
H
L
Y
Y
E
--
K
L
S
--
S
H
L
D
L
V
I
G
I
S
Q
S
G
Q
S
T
S
T
I
S
A
L
E
R
V
K
K
E
A
--
S
V
-
P
V
V
A
L
T
S
D
V
T
S
E
I
A
E
F
A
D
-----
I
T
L
D
I
--
G
S
G
--
K
E
-
R
V
G
Y
V
T
K
G
F
T
A
T
V
L
T
L
M
L
T
G
L
H
F
A
Y
-------
K
T
VQID
E
T
--
R
F
N
N
E
I
S
A
F
S
R
A
I
D
A
I
---
P
A
T
I
-
A
E
T
E
A
F
Y
E
R
W
Q
--
E
EF-
A
T
A
P
K
F
T
A
I
G
Y
G
P
T
V
G
T
C
K
-
E
F
E
T
K
F
S
E
T
V
R
----
V
P
-
S
Q
G
L
D
-
L
E
A
F
M
H
G
P
Y
L
E
V
N
P
Q
H
R
I
F
F
L
E
T
A
S
A
-
V
T
E
R
L
V
L
L
R
D
Y
E
-
S
K
Y
T
--
P
F
T
Y
T
V
K
F
G
K
G
-------
E
D
D
R
T
L
V
I
P
T
----
D
----
L
D
------
E
Y
Q
A
P
F
L
M
I
L
P
F
Q
I
L
A
H
H
I
A
E
L
K
G
N
K
L
T
E
R
I
Y
T
D
----------------
39
HHSearch
47.54
14%
-32
- C2 -
-
2AML
1
?
B:
[13-358]
------------
M
K
P
T
M
M
T
Y
I
N
E
E
E
E
M
C
R
V
I
L
A
D
F
Q
T
------
N
----
A
E
------
K
L
------
E
S
L
-
V
-
K
N
-
G
A
K
E
W
L
I
L
A
T
G
S
S
L
N
A
A
Q
S
A
K
Y
Y
I
E
N
L
-
A
D
---
V
R
I
T
I
E
E
P
F
N
H
L
Y
Y
E
--
K
L
S
--
S
H
L
D
L
V
I
G
I
S
Q
S
G
Q
S
T
S
T
I
S
A
L
E
R
V
K
K
E
A
--
S
V
-
P
V
V
A
L
T
S
D
V
T
S
E
I
A
E
F
A
D
-----
I
T
L
D
I
--
G
S
G
--
K
E
-
R
V
G
Y
V
T
K
G
F
T
A
T
V
L
T
L
M
L
T
G
L
H
F
A
Y
-------
K
T
VQID
E
T
--
R
F
N
N
E
I
S
A
F
S
R
A
I
D
A
I
---
P
A
T
I
-
A
E
T
E
A
F
Y
E
R
W
Q
--
E
EF-
A
T
A
P
K
F
T
A
I
G
Y
G
P
T
V
G
T
C
K
-
E
F
E
T
K
F
S
E
T
V
R
----
V
P
-
S
Q
G
L
D
-
L
E
A
F
M
H
G
P
Y
L
E
V
N
P
Q
H
R
I
F
F
L
E
T
A
S
A
-
V
T
E
R
L
V
L
L
R
D
Y
E
-
S
K
Y
T
--
P
F
T
Y
T
V
K
F
G
K
G
-------
E
D
D
R
T
L
V
I
P
T
----
D
----
L
D
------
E
Y
Q
A
P
F
L
M
I
L
P
F
Q
I
L
A
H
H
I
A
E
L
K
G
N
K
L
T
E
R
I
Y
T
D
----------------
45
HHSearch
46.95
18%
-5
- C2 -
-
1JXA
1
GLMS_ECOLI
C:
[241-607]
-----
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
------
H
GQVD
L
S
------
E
L
---
G
P
N
A
D
E
L
L
-
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
-
A
G
---
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
--
S
A
V
--
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
-
L
--
G
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
-----
L
A
L
M
T
--
N
A
G
--
T
E
-
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
-------
L
KGLDASIEH
D
---
I
V
H
G
L
Q
A
L
P
S
R
I
---
E
Q
M
L
-
S
Q
-
D
K
R
I
E
A
L
A
--
E
DF-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
-
E
G
A
L
K
L
K
E
I
S
Y
----
I
H
-
A
E
A
Y
A
-
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
-
L
L
E
K
L
K
S
N
I
E
E
V
-
R
A
R
G
--
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
--
S
D
N
M
H
I
I
E
M
P
-----
H
----
V
E
------
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
-----------
33
HHSearch
46.72
18%
-23
- C2 -
-
4S1W
1
?
B:
[3-347]
---------
K
G
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
A
V
M
R
R
I
I
Q
E
Y
Q
D
------
A
----
E
G
------
N
L
KID
Q
D
I
I
N
D
-
V
-
K
--
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
W
-
A
G
---
V
P
T
E
V
H
V
A
S
E
F
V
Y
N
M
--
P
L
L
--
S
E
K
P
L
F
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
-
L
--
G
H
-
K
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
-----
H
T
L
L
L
--
H
A
G
--
P
E
-
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
HEAD--
I
---------
D
---
L
L
R
E
L
A
K
V
T
T
A
I
---
E
A
I
V
-
D
D
-
A
P
I
M
E
Q
I
A
--
T
D
FL
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
-
E
G
A
L
K
L
K
E
I
S
Y
----
I
Q
-
A
E
G
F
A
-
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
-
V
N
L
S
I
R
G
N
V
K
E
V
-
V
A
R
G
--
A
H
P
C
I
I
S
M
E
G
L
E
K
------
E
G
D
T
Y
V
I
P
-----
H
----
V
H
------
E
L
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
L
D
V
D
K
---------------------
8
PsiBlast_PDB
46.28
24%
-70
- C2 -
-
2E5F
1
?
A:
[124-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
--
P
A
I
---
E
-
E
S
V
V
M
T
H
S
F
T
S
F
Y
F
A
Y
L
Q
L
L
R
-
Y
S
Y
-------
G
---------
L
---
P
P
L
N
A
G
E
I
S
K
A
T
---
E
K
S
L
-
E
Y
-
E
R
Y
I
R
E
I
V
--
E
S
--
F
D
F
Q
N
I
I
F
L
G
S
G
L
L
Y
P
V
A
L
-
E
A
S
L
K
M
K
E
M
S
I
FW
S
E
A
Y
-
P
T
F
E
-----
V
R
H
G
F
K
A
I
A
D
E
K
T
L
V
V
L
M
---
V
E
E
P
F
E
W
H
E
K
L
V
K
E
F
-
K
N
Q
G
A
K
V
L
V
I
S
N
S
P
Q
D
L
G
Q
-
D
--
Y
S
I
E
L
P
R
-------------
L
S
------
K
D
A
N
P
I
P
Y
L
P
I
V
Q
L
L
S
Y
Y
K
A
V
S
R
G
L
N
P
D
N
P
--------------------
6
PsiBlast_PDB
45.85
24%
-73
- C2 -
-
2DEC
1
?
A:
[124-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
--
P
A
I
---
E
-
E
S
V
V
M
T
H
S
F
T
S
F
Y
F
A
Y
L
Q
L
L
R
-
Y
S
Y
-------
G
---------
L
---
P
P
L
N
A
G
E
I
S
K
A
T
---
E
K
S
L
-
E
Y
-
E
R
Y
I
R
E
I
V
--
E
S
--
F
D
F
Q
N
I
I
F
L
G
S
G
L
L
Y
P
V
A
L
-
E
A
S
L
K
M
K
E
M
S
I
FW
S
E
A
Y
-
P
T
F
E
-----
V
R
H
G
F
K
A
I
A
D
E
K
T
L
V
V
L
M
---
V
E
E
P
F
E
W
H
E
K
L
V
K
E
F
-
K
N
Q
G
A
K
V
L
V
I
S
N
S
P
Q
D
L
G
Q
-
D
--
Y
S
I
E
L
P
R
-------------
L
S
------
K
D
A
N
P
I
P
Y
L
P
I
V
Q
L
L
S
Y
Y
K
A
V
S
R
G
L
N
P
D
N
P
--------------------
7
PsiBlast_PDB
45.72
24%
-70
- C2 -
-
2DF8
3
?
A:
[124-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
--
P
A
I
---
E
-
E
S
V
V
M
T
H
S
F
T
S
F
Y
F
A
Y
L
Q
L
L
R
-
Y
S
Y
-------
G
---------
L
---
P
P
L
N
A
G
E
I
S
K
A
T
---
E
K
S
L
-
E
Y
-
E
R
Y
I
R
E
I
V
--
E
S
--
F
D
F
Q
N
I
I
F
L
G
S
G
L
L
Y
P
V
A
L
-
E
A
S
L
K
M
K
E
M
S
I
FW
S
E
A
Y
-
P
T
F
E
-----
V
R
H
G
F
K
A
I
A
D
E
K
T
L
V
V
L
M
---
V
E
E
P
F
E
W
H
E
K
L
V
K
E
F
-
K
N
Q
G
A
K
V
L
V
I
S
N
S
P
Q
D
L
G
Q
-
D
--
Y
S
I
E
L
P
R
-------------
L
S
------
K
D
A
N
P
I
P
Y
L
P
I
V
Q
L
L
S
Y
Y
K
A
V
S
R
G
L
N
P
D
N
P
--------------------
26
HHSearch
44.10
16%
6
- C2 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[11-374]
--------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
FDDYTV
N
----
L
G
------
G
L
---
K
D
H
I
K
E
-
I
-
Q
--
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
-
T
E
---
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
-
P
-
V
--
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
-
R
--
G
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
-----
C
G
V
H
I
--
N
A
--
G
P
E
-
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
-------
D
RISM
Q
E
R
R
K
E
---
I
M
L
G
L
K
R
L
P
D
L
I
---
K
E
V
L
-
S
M
-
D
D
E
I
Q
K
L
A
--
T
E
L
-
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
-
E
G
A
L
K
I
K
E
I
T
Y
----
M
H
-
S
E
G
I
L
-
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
-
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
--
R
P
V
V
I
C
D
K
E
D
T
E
T
-
I
--
K
N
T
K
R
T
I
K
V
P
H
---------
S
V
------
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
-----------
42
HHSearch
43.86
16%
-40
- C2 -
-
3FKJ
-
?
A:
[39-346]
-------------------------------------------------------------------------
N
I
E
R
V
W
F
V
G
C
G
G
S
L
T
G
F
W
P
G
K
Y
F
L
D
C
E
A
S
K
---
L
A
V
G
Y
I
T
S
N
E
F
V
H
A
T
P
-
K
A
L
--
G
K
N
S
V
V
I
L
A
S
Q
Q
G
N
T
A
E
T
V
A
A
A
R
V
A
R
E
-
K
--
G
A
-
A
T
I
G
L
V
Y
Q
P
D
T
P
L
C
E
Y
S
D
-----
Y
I
I
E
Y
--
Q
W
A
R
Y
P
E
T
V
D
P
A
Q
Q
K
A
A
Y
S
L
W
L
A
L
E
I
L
A
Q
T
E
G
Y
AQ
Y
----
D
---------
E
---
L
V
S
A
F
G
R
F
S
D
V
V
---
H
G
A
Q
-
R
Q
V
Q
E
D
A
Q
R
F
A
--
A
E
W
-
K
D
E
K
V
V
Y
M
M
G
S
G
P
S
F
G
A
A
H
Q
E
S
I
C
I
L
L
E
M
Q
W
----
I
N
-
S
A
S
I
H
-
S
G
E
Y
F
H
G
P
F
E
I
T
E
P
G
T
P
F
I
L
L
Q
S
S
G
R
-
T
R
P
L
D
D
R
A
I
R
F
I
-
E
R
Y
Q
--
G
K
L
Q
L
I
D
A
D
K
L
G
--------
I
--
Q
D
L
S
T
----
D
----
V
G
------
E
Y
F
C
G
L
L
H
N
C
V
L
D
V
Y
N
L
A
L
A
T
A
R
N
H
P
L
T
T
R
R
Y
M
W
K
V
E
-------------
30
HHSearch
43.29
16%
2
- C2 -
-
2PUT
2
GFA1_CANAL
B:
[4-355]
-----------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
S
A
F
N
T
M
R
G
R
I
D
------
F
----
E
N
C
V
V
T
L
G
G
L
---
K
S
W
L
S
T
-
I
-
R
--
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
-
T
E
---
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
S
-
P
-
V
--
F
R
D
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
-
R
--
G
A
-
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
-----
C
G
V
H
I
--
N
A
G
--
P
E
-
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
-------
D
SISR
K
G
R
H
E
E
---
I
I
K
G
L
Q
K
I
P
E
Q
I
---
K
Q
V
L
-
K
L
-
E
N
K
I
K
D
L
C
--
N
SSL
N
D
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
-
E
G
A
L
K
I
K
E
I
S
Y
----
M
H
-
S
E
G
V
L
-
A
G
E
L
K
H
G
I
L
A
L
V
D
E
D
L
P
I
I
A
F
A
T
R
D
S
-
L
F
P
K
V
M
S
A
I
E
Q
V
-
T
A
R
D
--
G
R
P
I
V
I
C
N
E
G
D
A
I
-
I
SN
D
K
V
H
T
T
L
E
V
P
E
---------
T
V
------
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
----------------------