@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0065: (2017-12-14 )
MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVAPDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNASNCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEISYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSIAPDGVPAKTPEANRDVVKHVYNGTLLKDIFAEEDEQIQLASGLDHSFALPAGHDNAGFLYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHSDLKGQVILKAGQTFTSKTRYELVVK
Atome Classification :
(20 SA)
.........10.--.--......20....-....30........40........50........60.....-...70-........80........90........100.......110.---......120.---......130----.......140.......150.......160..-..-...170.......180.......190.......200.----...-...210.-......220.......230-----.........240.......250.....--.----.260.----........270..------.....280.......290.-.-.-....300.......310.......320.......330.......340...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
A
Y
T
E
R
V
FGNV--E--GE
D
V
L
A
Y
R
F
ETD-G
G
Y
Q
L
E
V
M
TY
G
A
T
I
L
R
YVAPDKAG
N
F
A
N
V
I
L
GFD
D
F
D
S
YVG-NSPKH-GASVGPVAGRIAG
A
T
F
E
LN
G
K
T
Y
D
L
EVNNASNCNHSGSTGWD---SS
L
F
E
V
EEVS---DH
G
L
T
L
Y
T
E----RTDGTGGFPG
N
L
K
I
W
I
S
Y
H
LEETG
A
Y
E
I
S
Y
K
V
-TT-DQDTLVNPTNH
S
Y
F
N
LSG
D
F
T
Q
T
I
D
R
H
V
F
Q
LNTE
G
I
Y
----
S
IA-PDGVPAK-TPEA
N
R
D
V
V
K
H
V
YNG
T
L
-------
L
K
D
I
FAEED
E
Q
I
Q
LASGLDHSFALPAG--H----DN--A----
G
F
L
Y
DQNS
G
R
F
L
L
------
F
KTEA
P
C
F
V
V
Y
TANFVDE
S
-
V
-I-IGGQP
M
L
QHN
G
I
A
L
E
A
Q
A
L
P
D
A
I
H
SDLK
G
Q
V
I
L
KAGQTFTSK
T
R
Y
E
L
V
VK
26
HHSearch
77.99
33%
18
- C2 -
-
4RNL
2
?
A:
[7-342]
--
Q
V
S
R
E
P
F
G
T
L
D-
D
--
G
T
R
V
D
R
W
T
L
E
S
G
P
A
G
L
R
V
R
V
L
T
Y
G
G
I
V
Q
T
V
E
A
P
D
R
D
G
M
R
G
Q
L
A
L
G
F
A
D
L
A
S
Y
A
A
H
G
G
S
Y
F
-
G
A
L
V
G
R
Y
A
N
R
I
A
G
A
S
F
V
L
D
G
R
T
D
A
L
T
P
N
N
G
R
H
S
L
H
G
G
P
G
G
F
S
---
R
V
V
W
D
A
R
E
V
D
----
G
G
V
Q
L
H
R
V
----
S
P
D
G
E
E
G
F
P
G
A
L
D
V
R
V
T
Y
T
L
S
A
-
G
A
L
R
I
V
S
C
A
T
T
--
D
A
P
T
V
V
N
L
T
N
H
T
Y
L
N
L
G
G
D
G
S
G
S
A
A
G
H
E
L
R
L
A
A
S
R
Y
T
----
P
V
D
-
G
T
G
I
P
V
P
G
A
P
A
E
V
T
G
T
R
F
D
F
R
A
A
R
A
-------
V
A
-------------
G
A
Y
D
H
N
F
A
L
D
G
G
--
V
REAP
R
T
--
V
----
A
E
L
Y
D
P
R
S
G
R
A
L
A
------
L
A
T
T
E
P
G
L
Q
L
Y
T
A
D
H
L
D
G
T
L
T
-
G
-
T
S
G
V
P
Y
G
P
A
A
G
L
A
L
E
T
Q
H
F
P
D
S
P
N
R
P
D
F
P
S
T
V
L
R
P
G
E
S
Y
R
S
E
T
V
Y
A
F
S
V
-
2
PsiBlast_PDB
77.35
30%
15
- C2 -
-
1SO0
1
GALM_HUMAN
A:
[3-343]
M
A
S
V
T
R
A
V
F
G
E
L
--
P
SG
G
G
T
V
E
K
F
Q
L
Q
S
D
-
L
-
L
R
V
D
I
I
S
W
G
C
T
I
T
A
L
E
V
K
D
R
Q
G
R
A
S
D
V
V
L
G
F
A
E
L
E
G
Y
L
Q
-
K
Q
P
Y
F
-
G
A
V
I
G
R
V
A
N
R
I
A
K
G
T
F
K
V
D
G
K
E
Y
H
L
A
I
N
K
E
P
N
S
L
H
G
G
V
R
G
F
D
---
K
V
L
W
T
P
R
V
L
S
---
N
-
G
V
Q
F
S
R
I
----
S
P
D
G
E
E
G
Y
P
G
E
L
K
V
W
V
T
Y
T
L
-
D
G
G
E
L
I
V
N
Y
R
A
-
Q
A
-
S
Q
A
T
P
V
N
L
T
N
H
S
Y
F
N
L
A
G
Q
A
S
P
N
I
N
D
H
E
V
T
I
E
A
D
T
Y
L
P
V
D
E
T
L
I
-
P
T
G
E
V
A
P
-
V
Q
G
T
A
F
D
L
R
K
P
V
E
L
G
K
H
-------
L
Q
D
F
H
---------
L
N
G
F
D
H
N
F
C
L
K
G
S
--
K
----
E
K
HF
C
----
A
R
V
H
H
A
A
S
G
R
V
L
E
------
V
Y
T
T
Q
P
G
V
Q
F
Y
T
G
N
F
L
D
G
T
-
L
-
K
G
K
N
G
A
V
Y
P
K
H
S
G
F
C
L
E
T
Q
N
W
P
D
A
V
N
Q
P
R
F
P
P
V
L
L
R
P
G
E
E
Y
D
H
T
T
W
F
K
F
S
V
-
28
HHSearch
76.64
24%
-29
* C2 *
-
1LUR
-
?
B:
[12-337]
-------------------
S
G
F
I
E
I
A
N
K
--
Q
G
L
T
A
T
L
L
P
F
G
A
T
L
A
K
L
T
F
P
D
K
N
G
K
N
Q
D
L
V
L
G
F
D
T
I
D
E
F
E
K
-
D
A
A
S
I
-
G
K
T
V
G
R
V
A
N
R
I
K
N
S
T
L
H
F
D
G
K
Q
Y
T
M
T
P
N
N
G
P
H
Y
L
H
G
G
P
N
G
L
G
---
Y
R
K
W
E
V
V
R
H
A
---
P
E
S
V
S
F
S
V
R
----
A
N
E
Q
D
D
G
L
P
G
D
A
K
I
D
V
T
Y
T
V
N
D
R
N
Q
L
I
I
E
H
H
--
A
T
C
D
T
P
G
L
L
A
L
T
N
H
A
Y
W
N
L
D
G
S
D
--
T
V
A
E
H
F
L
E
M
E
A
D
E
F
V
----
E
V
D
-
D
T
F
C
P
T
G
-
A
I
R
S
V
T
D
T
G
F
D
F
R
S
G
K
Q
-------
L
K
E
S
G
K
D
A
E
E
----
L
L
D
L
D
N
D
L
V
I
T
K
K
--
T
P---
S
T
--
Y
----
L
R
F
W
S
E
K
S
G
I
E
L
S
------
I
T
T
S
Y
P
V
I
H
L
Y
A
S
K
F
L
D
C
K
-
G
---
K
K
G
E
H
Y
K
A
N
K
A
L
A
I
E
P
Q
F
H
S
A
A
P
N
F
D
H
F
P
D
V
S
L
R
P
G
D
H
Y
C
Q
E
I
V
Y
T
F
S
H
-
25
HHSearch
76.41
33%
19
- C2 -
-
4RNL
2
?
B:
[7-342]
--
Q
V
S
R
E
P
F
G
T
L
D-
D
--
G
T
R
V
D
R
W
T
L
E
S
G
P
A
G
L
R
V
R
V
L
T
Y
G
G
I
V
Q
T
V
E
A
P
D
R
D
G
M
R
G
Q
L
A
L
G
F
A
D
L
A
S
Y
A
A
H
G
G
S
Y
F
-
G
A
L
V
G
R
Y
A
N
R
I
A
G
A
S
F
V
L
D
G
R
T
D
A
L
T
P
N
N
G
R
H
S
L
H
G
G
P
G
G
F
S
---
R
V
V
W
D
A
R
E
V
D
----
G
G
V
Q
L
H
R
V
----
S
P
D
G
E
E
G
F
P
G
A
L
D
V
R
V
T
Y
T
L
S
A
-
G
A
L
R
I
V
S
C
A
T
T
--
D
A
P
T
V
V
N
L
T
N
H
T
Y
L
N
L
G
G
D
G
S
G
S
A
A
G
H
E
L
R
L
A
A
S
R
Y
T
----
P
V
D
-
G
T
G
I
P
V
P
G
A
P
A
E
V
T
G
T
R
F
D
F
R
A
A
R
A
-------
V
A
-------------
G
A
Y
D
H
N
F
A
L
D
G
G
--
V
REAP
R
T
--
V
----
A
E
L
Y
D
P
R
S
G
R
A
L
A
------
L
A
T
T
E
P
G
L
Q
L
Y
T
A
D
H
L
D
G
T
L
T
-
G
-
T
S
G
V
P
Y
G
P
A
A
G
L
A
L
E
T
Q
H
F
P
D
S
P
N
R
P
D
F
P
S
T
V
L
R
P
G
E
S
Y
R
S
E
T
V
Y
A
F
S
V
-
1
PsiBlast_PDB
76.09
30%
13
- C- -
-
1SNZ
-
GALM_HUMAN
A:
[1-341]
M
A
S
V
T
R
A
V
F
G
E
L
--
P
SG
G
G
T
V
E
K
F
Q
L
Q
S
D
-
L
-
L
R
V
D
I
I
S
W
G
C
T
I
T
A
L
E
V
K
D
R
Q
G
R
A
S
D
V
V
L
G
F
A
E
L
E
G
Y
L
Q
-
K
Q
P
Y
F
-
G
A
V
I
G
R
V
A
N
R
I
A
K
G
T
F
K
V
D
G
K
E
Y
H
L
A
I
N
K
E
P
N
S
L
H
G
G
V
R
G
F
D
---
K
V
L
W
T
P
R
V
L
S
---
N
-
G
V
Q
F
S
R
I
----
S
P
D
G
E
E
G
Y
P
G
E
L
K
V
W
V
T
Y
T
L
-
D
G
G
E
L
I
V
N
Y
R
A
-
Q
A
-
S
Q
A
T
P
V
N
L
T
N
H
S
Y
F
N
L
A
G
Q
A
S
P
N
I
N
D
H
E
V
T
I
E
A
D
T
Y
L
P
V
D
E
T
L
I
-
P
T
G
E
V
A
P
-
V
Q
G
T
A
F
D
L
R
K
P
V
E
L
G
K
H
-------
L
Q
D
F
H
---------
L
N
G
F
D
H
N
F
C
L
K
G
S
--
K
----
E
K
H
F
C
----
A
R
V
H
H
A
A
S
G
R
V
L
E
------
V
Y
T
T
Q
P
G
V
Q
F
Y
T
G
N
F
L
D
G
T
-
L
-
K
G
K
N
G
A
V
Y
P
K
H
S
G
F
C
L
E
T
Q
N
W
P
D
A
V
N
Q
P
R
F
P
P
V
L
L
R
P
G
E
E
Y
D
H
T
T
W
F
K
F
S
V
-
29
HHSearch
73.32
26%
22
- C2 -
-
3IMH
3
?
B:
[14-330]
--------------
D
--
N
K
D
L
C
E
I
T
L
E
N
D
-
A
G
M
A
V
K
V
L
N
Y
G
A
T
L
E
K
V
L
L
D
G
E
-----
N
M
I
L
S
L
N
S
P
E
D
Y
S
K
-
E
R
N
F
L
-
G
G
T
V
G
R
I
A
G
R
V
R
A
G
Q
W
K
H
G
N
E
I
H
Q
L
P
L
N
D
G
D
N
H
I
H
G
G
---
I
G
TD-
M
H
V
W
D
F
R
P
S
C
DSE
H
A
R
V
D
L
T
L
F
----
D
P
D
G
N
N
D
Y
P
G
N
L
K
L
H
A
R
Y
E
L
D
N
E
N
N
L
H
Y
L
L
E
A
V
S
--
D
K
L
T
I
F
N
P
V
N
H
T
Y
F
N
L
G
E
R
----
A
E
D
L
N
L
Q
M
N
A
D
Y
Y
L
----
P
V
D
-
E
A
G
L
P
D
R
-
G
M
A
E
V
A
G
T
A
F
D
F
R
K
T
K
R
-------
I
G
D
A
L
N
S
D
D
S
Q
I
K
L
R
N
G
L
D
H
P
F
I
L
N
G
N
--------
N
--
P
----
A
A
L
L
S
S
-
N
K
H
R
L
I
------
V
K
T
N
A
P
A
L
V
L
Y
A
G
N
H
F
N
H
T
-
G
----
I
V
N
N
I
G
Q
Y
D
G
I
T
F
E
A
Q
C
P
P
A
E
G
N
D
L
--
G
Q
I
T
L
L
P
F
E
K
F
K
R
T
V
D
W
K
F
E
--
24
HHSearch
72.61
29%
16
- C- -
-
1SNZ
-
GALM_HUMAN
A:
[1-341]
M
A
S
V
T
R
A
V
F
G
E
L
P
S
G
--
G
G
T
V
E
K
F
Q
L
Q
S
--
D
L
L
R
V
D
I
I
S
W
G
C
T
I
T
A
L
E
V
K
D
R
Q
G
R
A
S
D
V
V
L
G
F
A
E
L
E
G
Y
L
Q
-
K
Q
P
Y
F
-
G
A
V
I
G
R
V
A
N
R
I
A
K
G
T
F
K
V
D
G
K
E
Y
H
L
A
I
N
K
E
P
N
S
L
H
G
G
---
V
R
GFD
K
V
L
W
T
P
R
V
L
----
S
N
G
V
Q
F
S
R
I
----
S
P
D
G
E
E
G
Y
P
G
E
L
K
V
W
V
T
Y
T
L
D
G
-
G
E
L
I
V
N
Y
R
A
Q
A
--
S
Q
A
T
P
V
N
L
T
N
H
S
Y
F
N
L
A
G
Q
A
S
P
N
I
N
D
H
E
V
T
I
E
A
D
T
Y
L
----
P
V
D
-
E
T
L
I
P
T
G
-
E
V
A
P
V
Q
G
T
A
F
D
L
R
K
P
V
E
-------
L
G
K
H
L
Q
D
-----
F
H
L
N
G
F
D
H
N
F
C
L
K
G
S
K
E
K
----
H
F
--
C
----
A
R
V
H
H
A
A
S
G
R
V
L
E
------
V
Y
T
T
Q
P
G
V
Q
F
Y
T
G
N
F
L
D
G
T
-
L
K
G
-
K
N
G
A
V
Y
P
K
H
S
G
F
C
L
E
T
Q
N
W
P
D
A
V
N
Q
P
R
F
P
P
V
L
L
R
P
G
E
E
Y
D
H
T
T
W
F
K
F
S
V
-
27
HHSearch
72.45
26%
22
- C2 -
-
1NSU
1
?
B:
[2-338]
--
S
I
K
I
R
D
F
G
--------
L
G
S
D
L
I
S
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
-----
K
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
N
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
V
T
D
LGA
E
V
Q
V
K
F
S
L
V
----
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
V
----
P
L
K
D
Q
T
E
I
V
R
G
-
D
I
V
D
I
K
N
T
D
L
D
F
R
Q
E
K
Q
-------
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
D
Q
L
--
G
LD--
K
E
--
Q
----
A
R
L
T
L
D
--
D
T
S
I
S
------
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
-
16
PsiBlast_PDB
72.04
29%
22
- C2 -
-
1NS7
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
A
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
11
PsiBlast_PDB
72.04
29%
22
- C2 -
-
1NS0
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
Q
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
3
PsiBlast_PDB
71.95
33%
12
- C2 -
-
4RNL
2
?
A:
[33-343]
-------------------------------
G
L
R
V
R
V
L
T
Y
G
G
I
V
Q
T
V
E
A
P
D
R
D
G
M
R
G
Q
L
A
L
G
F
A
D
L
A
S
Y
A
A
-
H
G
G
S
Y
F
G
A
L
V
G
R
Y
A
N
R
I
A
G
A
S
F
V
L
D
G
R
T
D
A
L
T
P
N
N
G
R
H
S
L
H
G
G
P
G
G
F
S
---
R
V
V
W
D
A
R
E
V
----
D
G
G
V
Q
L
H
R
V
----
S
P
D
G
E
E
G
F
P
G
A
L
D
V
R
V
T
Y
T
L
-
S
A
G
A
L
R
I
V
S
C
A
-
T
T
-
D
A
P
T
V
V
N
L
T
N
H
T
Y
L
N
L
G
G
D
G
S
G
S
A
A
G
H
E
L
R
L
A
A
S
R
Y
T
----
P
V
D
-
G
T
G
I
P
---
V
P
G
A
P
A
E
V
T
G
T
R
F
D
F
R
A
-------
A
R
A
V
----------
A
G
A
Y
D
H
N
F
A
L
D
G
G
--
V
----
R
E
--
A
PRTV
A
E
L
Y
D
P
R
S
G
R
A
L
A
------
L
A
T
T
E
P
G
L
Q
L
Y
T
A
D
H
L
D
G
T
-
L
-
T
G
T
S
G
V
P
Y
G
P
A
A
G
L
A
L
E
T
Q
H
F
P
D
S
P
N
R
P
D
F
P
S
T
V
L
R
P
G
E
S
Y
R
S
E
T
V
Y
A
F
S
V
R
7
PsiBlast_PDB
71.29
29%
24
- C2 -
-
1MMX
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
5
PsiBlast_PDB
71.24
29%
20
- C2 -
-
1L7K
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
14
PsiBlast_PDB
70.98
29%
21
- C2 -
-
1NSR
-
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
N
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
19
PsiBlast_PDB
70.47
29%
23
- C2 -
-
1NSX
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
N
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
13
PsiBlast_PDB
70.46
29%
21
- C2 -
-
1NS8
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
N
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
6
PsiBlast_PDB
70.45
29%
21
- C2 -
-
1MMU
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
18
PsiBlast_PDB
70.09
29%
23
- C2 -
-
1NSV
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
N
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
17
PsiBlast_PDB
70.06
29%
24
- C2 -
-
1NSU
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
N
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
12
PsiBlast_PDB
70.02
29%
22
- C2 -
-
1NS4
1
?
A:
[11-339]
-----------------
G
S
D
L
I
S
--
L
T
N
K
-
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
-----
H
L
I
L
G
F
D
S
A
K
E
Y
L
E
-
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
---
T
K
L
W
T
Y
E
-
V
T
---
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
-
I
S
-
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
E
S
V
E
N
H
-------
G
L
R
----
L
A
A
-
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D
L
DFRQEKQ
L
S
N
A
F
N
S
N
M
E
Q
V
Q
L
V
K
G
I
D
H
P
F
L
L
----------
D
Q
--
L
----
G
L
--
D
K
E
Q
A
R
L
T
L
DD
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
-
T
-
L
-
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
Q
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
D
I
S
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K