@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0083: (2017-12-15 )
MIFIEYKIITLFISLKIKKGVFIMKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIKMYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAFADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQNFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPVANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQDTWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEKSMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNWILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINTGTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70...-.-.--...80........90.........100-.-......110.......120...----...----.-130.......140.......150.....---.---.160..-.-....170....-..---.180------.........190.......200.......210.......220-------.------.......230..-.--.....-.240.--.---...--.----------...250.......260.......270.......280.......290---.-----.------.---.....300....--.-...310.--...--...-320.......330..--.-.-.------.-------.-------340....---.....350.......360.......370.......380.....----..390....-..-.400.--..---.-.----.-..--.---410-.-------....------...-420-..-.-.....430------....----.-.-..440......-..-----450-.----........460.......470--.......480.......490...-....500.......510..--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
F
I
E
Y
K
I
I
T
L
F
I
S
L
K
IKK
G
V
F
I
MKNW
K
K
YAFA
S
A
S
V
V
A
L
A
A
G
L
A
A
CGNLTGNSKKAADSGDK
P
V
I
K
M
Y
QIGDK-P-D--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
KVG
A
K
L
D
I
Q
Y
L
-G-WGDYG
K
K
M
S
V
I
TSSGE
N
Y
D
I
A
F----AD
N
----
Y
-
I
V
NAQKGA
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
ALD---P---
A
Y
IKGN-T-VN
G
K
I
Y
A
V
P
V
A
-AN---VA--------SSQ
N
F
A
FN
G
T
L
L
A
K
YGIDISGVT
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
KAPD--------V------VPF
A
I
G
K
V
--
F
I-P--SDNFD-YP--V--A---NGL--
P
----------
F
V
I
DLEG
D
T
T
K
V
V
N
RYEV
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
EAGYIPKDVATSD----T-----S------F---DLQQ
D
T
W
-
F
V
RE--E-TVGP
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
ANK
D
I
Q
I
K
P
I
T
N
F
--
I
-K-K------N-------Q-------T--
T
Q
V
A
---
N
F
V
ISNNSKN
K
E
K
S
M
E
I
L
N
L
LNT
N
P
E
L
L
N
G
L
V
YGPEGKNWEKI----EGKE
N
R
V
R
V
-
L
D-GY--K--GN---T-H----M-GG--W---N-T-G-------N
N
W
I
------
L
Y
I-N-E-NV-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-AKE-SPA
L
G
F
I
-FN-----T---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
AIN--TGTVD
P
D
K
A
I
P
E
L
M
E
K
L
K
SEG
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
LKNKK--
3
PsiBlast_PDB
84.36
100%
-62
- C1 -
-
5SUO
-
?
A:
[1-452]
--------------------------------------------------------------
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
------------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
K
--
52
Fugue
83.89
100%
-55
- C1 -
-
5SWB
6
?
A:
[17-470]
--------------------------------------------------------------
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
K
LE
21
PsiBlast_CBE
83.84
99%
-54
- C1 -
-
5SWB
10
?
G:
[17-468]
--------------------------------------------------------------
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
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A
G
Y
I
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K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
K
--
23
PsiBlast_CBE
83.56
99%
-56
- C1 -
-
5SWB
5
?
C:
[18-468]
---------------------------------------------------------------
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
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A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
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D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
K
--
24
PsiBlast_CBE
83.51
99%
-56
- C1 -
-
5SWA
2
?
B:
[17-466]
--------------------------------------------------------------
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
----
1
PsiBlast_PDB
83.33
99%
-60
- C1 -
-
5SWA
2
?
A:
[17-466]
--------------------------------------------------------------
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
--
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
----
2
PsiBlast_PDB
83.03
99%
-55
- C1 -
-
5SWB
6
?
A:
[17-468]
--------------------------------------------------------------
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
K
--
4
PsiBlast_PDB
78.96
98%
-75
- C1 -
-
5MLT
-
?
A:
[3-454]
-------------------------------------------------------------
D
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
------
F
---
D
L
Q
Q
D
T
W
-
F
V
R
E
--
E
-
T
V
G
P
A
D
Y
--
G
N
S
--
L
L
S
-
R
V
A
N
K
D
I
Q
I
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
A
Y
-
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
---
33
HHSearch
75.57
94%
-7
- C1 -
-
5SUO
-
?
A:
[2-452]
---------------------------------------------------------------
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
------FDLQQD
T
---
W
F
V
R
E
E
T
V
G
P
A
D
-----
Y
G
N
S
-
L
--
L
S
R
--
V
---
A
N
K
D
I
Q
I
--
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
-
A
Y
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
K
--
32
HHSearch
70.86
94%
-20
- C1 -
-
5MLT
-
?
A:
[3-454]
-------------------------------------------------------------
D
K
P
V
I
K
M
Y
Q
I
G
D
K
-
P
-
D
--
N
L
D
E
L
L
A
N
A
N
K
I
I
E
-
E
K
V
G
A
K
L
D
I
Q
Y
L
-
G
-
W
G
D
Y
G
K
K
M
S
V
I
T
S
S
G
E
N
Y
D
I
A
F
----
A
D
N
----
Y
-
I
V
N
A
Q
K
G
A
Y
A
D
L
T
E
L
Y
K
K
E
G
K
D
L
Y
K
A
L
D
---
P
---
A
Y
I
K
G
N
-
T
-
V
N
G
K
I
Y
A
V
P
V
A
-
A
N
---
V
A
--------
S
S
Q
N
F
A
F
N
G
T
L
L
A
K
Y
G
I
D
I
S
G
V
T
S
Y
E
T
L
E
P
V
L
K
Q
I
K
E
K
A
P
D
--------
V
------
V
P
F
A
I
G
K
V
--
F
I
-
P
--
S
D
N
F
D
-
Y
P
--
V
--
A
---
N
G
L
--
P
----------
F
V
I
D
L
E
G
D
T
T
K
V
V
N
R
Y
E
V
P
R
F
K
E
H
L
K
T
L
H
K
F
Y
E
A
G
Y
I
P
K
D
V
A
T
S
D
----
T
-----
S
F
D
LQQD
T
---
W
F
V
R
E
E
T
V
G
P
A
D
-----
Y
G
N
S
L
L
---
S
R
--
V
---
A
N
K
D
I
Q
I
--
K
P
I
T
N
F
--
I
-
K
-
K
------
N
-------
Q
-------
T
--
T
Q
V
A
---
N
F
V
I
S
N
N
S
K
N
K
E
K
S
M
E
I
L
N
L
L
N
T
N
P
E
L
L
N
G
L
V
Y
G
P
E
G
K
N
W
E
K
I
----
E
G
K
E
N
R
V
R
V
-
L
D
-
G
Y
--
K
--
G
N
---
T
-
H
----
M
-
G
G
--
W
---
N
-
T
-
G
-------
N
N
W
I
------
L
Y
I
-
N
-
E
-
N
V
-
T
-
D
Q
Q
I
E
N
-
S
------
K
K
E
L
----
A
-
E
-
A
K
E
-
S
P
A
L
G
F
I
-
F
N
-----
T
---
D
----
N
V
K
S
E
I
S
A
I
A
N
T
M
Q
Q
F
D
T
A
I
N
--
T
G
T
V
D
P
D
K
A
I
P
E
L
M
E
K
L
K
S
E
G
-
A
Y
E
K
V
L
N
E
M
Q
K
Q
Y
D
E
F
L
K
N
K
---
29
PsiBlast_CBE
41.21
37%
-164
- C2 -
-
4XTC
1
?
Q:
[465-516]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
T
Y
M
Y
E
M
G
Q
A
W
V
--
M
G
T
K
D
V
D
K
T
W
D
E
Y
Q
R
Q
L
K
L
R
G
L
Y
-
Q
-
V
L
Q
M
M
Q
Q
A
Y
D
R
Q
Y
K
N
----
53
Fugue
39.08
17%
45
- C1 -
-
1KWH
-
?
A:
[1-492]
------------------------------------------------------
K
E
A
T
W
V
T
D
K
P
L
T
L
K
I
H
M
H
F
R
-
D
-
K
--
W
V
W
D
E
N
W
P
V
A
K
E
S
F
-
R
L
T
N
V
K
L
Q
S
V
A
N
K
A
-
A
T
N
S
Q
E
Q
F
N
L
M
M
A
S
G
D
L
P
D
V
V
G
G
D
NL
K
D
K
----
F
-
I
Q
Y
G
Q
E
G
A
F
V
P
L
N
K
L
I
D
Q
Y
A
P
H
I
K
A
F
F
K
S
H
P
E
---
V
E
R
A
I
K
-
A
-
P
D
G
N
I
Y
F
I
P
Y
V
-
P
D
---
G
V
--------
V
A
R
G
Y
F
I
R
E
D
W
L
K
K
L
N
L
K
--
P
P
Q
N
I
D
E
L
Y
T
V
L
K
A
F
K
E
K
D
P
N
GNGKADEV
P
------
F
I
D
R
H
P
D
E
--
V
F
-
R
--
L
V
N
F
W
-
G
A
--
R
--
S
---
S
G
S
--
D
----------
N
Y
M
D
F
Y
I
D
N
G
R
V
K
H
P
W
A
E
T
A
F
R
D
G
M
K
H
V
A
Q
W
Y
K
E
G
L
I
D
K
E
I
F
T
R
K
AKAR
E
-----
Q
------
M
---
F
G
G
N
L
G
G
-
F
T
H
D
--
W
-
F
A
S
T
M
T
F
--
N
E
G
--
L
A
K
-
T
V
P
G
F
K
L
I
P
I
A
P
P
T
N
--
S
-
K
-
G
------
Q
-------
R
WEEDSRQ
K
--
V
R
P
D
---
G
W
A
I
T
V
K
N
K
N
P
V
E
T
I
K
F
F
D
F
Y
-
F
S
R
P
G
R
D
I
S
N
F
G
V
P
G
V
T
Y
D
I
K
----
N
G
K
A
V
F
K
D
S
-
V
L
-
K
S
--
P
--
Q
P
---
V
-
N
----
N
-
Q
L
--
Y
---
D
-
M
-
G
-------
A
Q
I
P
I
G
F
W
Q
D
Y
D
Y
-
E
-
R
-
Q
W
-
T
-
T
P
E
A
Q
A
-
G
------
I
D
M
Y
----
V
-
K
-
G
K
Y
-
V
M
P
G
F
E
G
-
V
N
M
T
R
E
E
R
---
A
----
I
Y
D
K
Y
W
A
D
V
R
T
Y
M
Y
E
M
G
Q
A
W
V
--
M
G
T
K
D
V
D
K
T
W
D
E
Y
Q
R
Q
L
K
L
R
G
-
L
-
Y
Q
V
L
Q
M
M
Q
Q
A
Y
D
R
Q
Y
K
N
----
36
HHSearch
37.86
19%
50
- C1 -
-
1J1N
1
?
B:
[8-491]
------------------------------------------------------------
D
K
P
L
T
L
K
I
H
M
H
F
R
D
-
K
-
W
--
V
W
D
E
N
W
P
V
A
K
E
S
F
R
-
L
-
T
N
V
K
L
Q
S
V
A
N
-
K
A
A
T
N
S
Q
E
Q
F
N
L
M
M
A
S
G
D
L
P
D
V
V
G
----
G
D
N
LKD-
K
F
I
Q
Y
G
Q
E
G
A
F
V
P
L
N
K
L
I
D
Q
Y
A
P
H
I
-
K
A
F
F
KSH
P
---
E
V
E
R
A
I
-
K
A
P
D
G
N
I
Y
F
I
P
Y
V
-
P
D
---
G
V
--------
V
A
R
G
Y
F
I
R
E
D
W
L
K
K
L
N
L
K
P
--
P
Q
N
I
D
E
L
Y
T
V
L
K
A
F
K
E
K
D
P
N
GNGKAD--
E
------
V
P
F
I
D
R
H
P
--
D
E
-
V
--
F
R
L
V
N
-
F
W
GA
R
--
S
---
S
G
S
--
D
----------
N
Y
M
D
F
Y
I
D
N
G
R
V
K
H
P
W
A
E
T
A
F
R
D
G
M
K
H
V
A
Q
W
Y
K
E
G
L
I
D
K
E
I
F
T
R
K
----
A
KA---
R
------
E
---
Q
M
F
G
G
N
L
-
G
G
F
T
--
H
-
D
W
F
A
S
T
M
--
T
F
N
EG
L
A
K
-
T
V
P
G
F
K
L
I
P
I
A
P
P
T
N
--
S
K
G
-
Q
RWEEDS
R
-------
Q
-------
K
--
V
R
P
D
---
G
W
A
I
T
V
K
N
K
N
P
V
E
T
I
K
F
F
D
F
Y
F
S
R
-
P
G
R
D
I
S
N
F
G
V
P
G
V
T
Y
D
I
K
----
N
G
K
A
V
-
F
---
K
D
-
S
V
--
L
--
K
S
---
P
-
Q
----
P
V
N
N
--
Q
---
L
-
Y
-
D
MGAQIPI
G
F
W
Q
------
D
Y
D
-
Y
-
E
R
Q
W
-
T
T
P
E
A
Q
A
G
-
I
------
D
M
Y
V
----
K
G
K
-
Y
V
M
-
P
G
F
E
G
V
N
-
M
T
-----
R
EER
A
----
I
Y
D
K
Y
W
A
D
V
R
T
Y
M
Y
E
M
G
Q
A
W
V
--
M
G
T
K
D
V
D
K
T
W
D
E
Y
Q
R
Q
L
K
L
R
G
-
L
-
Y
Q
V
L
Q
M
M
Q
Q
A
Y
D
R
Q
Y
K
-----
30
PsiBlast_CBE
37.59
37%
-131
- C2 -
-
4XIG
1
?
Q:
[465-516]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
T
Y
M
Y
E
M
G
Q
A
W
V
--
M
G
T
K
D
V
D
K
T
W
D
E
Y
Q
R
Q
L
K
L
R
G
L
Y
-
Q
-
V
L
Q
M
M
Q
Q
A
Y
D
R
Q
Y
K
N
----
35
HHSearch
37.41
16%
33
- C1 -
-
3A09
1
?
A:
[7-489]
-----------------------------------------------------------
T
E
K
P
L
T
L
K
I
H
M
H
F
R
D
-
K
-
W
--
V
W
-
D
E
N
W
P
V
A
R
E
V
A
-
R
L
T
N
V
K
L
V
G
V
A
N
R
A
-
A
T
N
S
Q
E
Q
F
N
L
M
M
A
S
G
Q
L
P
D
I
V
G
----
G
D
N
L
K
D
-
K
F
I
R
Y
G
M
E
G
A
F
I
P
L
N
K
L
I
D
Q
N
A
P
N
L
-
K
A
F
F
K
T
H
P
---
E
V
Q
R
A
I
T
A
-
P
D
G
N
I
Y
Y
L
P
Y
V
-
P
D
---
G
L
--------
V
S
R
G
Y
F
I
R
Q
D
W
L
D
K
L
H
L
K
T
--
P
Q
T
V
D
E
L
Y
T
V
L
K
A
F
K
E
K
D
P
N
GNGKAD--
E
------
I
P
F
I
N
R
D
P
--
E
E
----
V
F
R
L
V
-
N
F
--
W
--
G
ARS
T
G
S
--
N
----------
T
W
M
D
F
Y
V
E
N
G
K
I
K
H
P
F
A
E
V
A
F
K
D
G
I
K
H
V
A
Q
W
Y
K
E
G
L
I
D
P
E
I
F
T
R
K
----
A
-----
R
------
S
REQ
T
F
G
N
N
I
G
-
G
M
T
H
--
D
--
W
F
A
S
T
A
L
F
N
D
A
--
L
S
K
-
N
I
P
G
F
K
L
V
P
M
A
P
P
I
N
--
S
K
G
Q
R
WEEDA-
R
-------
Q
-------
I
--
P
R
P
D
---
G
W
A
I
T
A
T
N
K
N
P
V
E
T
I
K
L
F
D
F
Y
F
G
P
-
K
G
R
E
L
S
N
F
G
V
P
G
L
T
Y
D
I
K
----
N
G
-
K
P
V
Y
K
--
D
--
T
V
--
L
--
K
A
AQP
V
-
N
----
N
-
Q
M
--
Y
D
I
G
A
Q
I
P
I
-------
G
F
W
Q
------
D
Y
E
Y
E
-
R
-
Q
W
-
T
-
N
D
V
A
L
Q
G
I
------
D
M
Y
I
----
K
N
K
-
Y
V
L
-
P
Q
F
T
G
V
N
-
L
T
-----
V
E
E
R
E
----
I
Y
D
K
Y
W
P
D
V
K
T
Y
M
F
E
M
G
Q
S
W
V
--
M
G
T
K
D
P
E
K
T
W
N
D
Y
Q
Q
Q
L
K
N
R
G
-
F
-
Y
Q
V
M
I
V
M
Q
K
A
Y
D
R
Q
-------
34
HHSearch
37.17
19%
67
- C1 -
-
3OMB
-
?
A:
[33-535]
-----------------------------------------------------
T
T
---
T
A
D
G
K
P
I
V
T
V
L
V
K
K
N
A
-
N
Q
E
KM
A
N
M
Q
W
A
K
D
L
E
-----
A
D
C
D
C
K
I
E
W
Q
E
V
-
T
-
R
E
A
W
A
Q
Q
K
N
A
T
L
A
S
G
D
I
A
D
V
N
L
----
N
G
Y
G---
A
V
E
A
Y
Q
Y
P
G
M
F
E
D
L
S
K
D
L
D
K
L
-
P
N
V
-
K
A
F
F
---
K
Q
K
P
D
A
K
K
M
S
T
D
-
S
K
G
R
I
Y
A
I
A
D
G
-
R
G
KAY
S
G
--------
T
G
Q
H
M
L
I
N
K
A
W
L
D
K
L
G
L
Q
V
--
P
T
T
W
D
E
L
E
N
V
L
K
A
F
K
T
Q
D
P
N
--------
G
NGQADE
I
P
M
N
I
K
K
L
--
E
G
S
Y
--
F
T
W
Y
S
P
M
L
--
L
LN
S
---
T
G
I
--
V
T
G
FNKGVSEY
G
F
Y
--
A
-
K
N
G
V
V
K
S
F
L
T
S
D
E
Y
K
E
V
I
K
Y
Y
H
K
L
I
S
E
G
L
I
P
A
E
W
A
T
K
D
----
D
-----
D
A
Y
N
A
--
D
---
Q
I
S
D
G
K
T
-
A
K
T
G
VV
F
-
G
W
S
P
S
-----
D
N
--
F
G
K
---
L
K
D
Q
Y
I
A
M
P
V
P
S
A
--
P
G
V
-
S
PD----
Q
TVWDGSS
S
-------
E
--
L
S
P
A
---
G
L
S
I
S
S
H
A
A
N
K
D
A
A
L
K
L
A
N
L
L
Y
S
E
-
K
Y
S
V
Q
Q
F
L
G
S
F
G
K
A
I
T
K
T
----
G
E
H
E
Y
--
T
V
-
D
N
D
K
L
--
S
Q
L
T
G
D
NQ
Y
-
P
G---
L
-
S
E
LL
V
---
G
-
W
-
I
-------
P
D
-
E
------
A
T
I
-
K
G
D
-
T
H
-
A
-
D
E
L
I
E
V
-
N
K
V
Y
EEQ
R
S
H
F
----
D
-
P
V
K
D
Y
I
P
D
Y
V
N
M
D
N
M
D
-----
P
---
S
----
D
A
T
K
L
N
T
N
N
A
E
I
F
N
T
T
M
Q
K
T
A
T
W
M
S
K
G
G
I
D
E
E
W
D
A
Y
C
K
Q
L
D
S
I
G
-
L
-
Q
E
S
T
K
I
W
Q
K
W
Y
D
T
Y
T
K
-----
31
PsiBlast_CBE
36.87
37%
-131
* C2 *
-
4TQU
1
?
Q:
[465-516]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
T
Y
M
Y
E
M
G
Q
A
W
V
--
M
G
T
K
D
V
D
K
T
W
D
E
Y
Q
R
Q
L
K
L
R
G
L
Y
-
Q
-
V
L
Q
M
M
Q
Q
A
Y
D
R
Q
Y
K
N
----
55
Fugue
34.65
12%
1
- C1 -
-
2B3F
1
?
A:
[1-392]
---
M
K
L
E
I
F
S
W
W
A
G
D
E
G
P
A
L
E
A
L
I
R
L
Y
K
Q
K
-
Y
P
G
V
E
V
I
N
A
T
V
T
G
G
A
G
V
N
A
R
A
V
L
K
T
R
M
L
G
G
D
P
P
D
T
F
Q
V
H
A
G
----------
M
E
L
I
G
T
-----------------------------------------------------------
W
V
V
A
N
R
M
E
D
L
S
A
L
F
R
Q
E
G
--
W
L
Q
A
F
P
---
K
---
G
L
I
D
L
I
-
S
-
Y
K
G
G
I
W
S
V
P
V
---
N
---
I
H
--------
R
S
N
V
M
W
Y
L
P
A
K
L
K
G
W
G
V
N
--
P
P
R
T
W
D
K
F
L
A
T
C
Q
T
L
K
Q
K
--
G
--------
L
------
E
A
P
L
A
L
G
E
--
N
W
-
T
--
Q
Q
H
L
W
-
E
S
--
V
--
A
---
L
A
V
L
G
P
----------
D
D
W
N
N
L
W
N
G
K
L
K
F
T
D
P
K
A
V
R
A
W
E
V
F
G
R
V
L
D
C
A
N
K
D
A
A
G
L
S
W
Q
Q
A
V
----
D
-----
R
------
V
---
V
Q
G
K
A
A
F
-
N
I
---------
M
G
D
W
--
A
A
G
--
Y
M
T
-
T
T
L
K
L
K
P
G
T
D
F
A
W
A
P
--
S
-
P
-
G
------
T
-------
Q
-------
G
--
V
F
M
M
L
S
D
S
F
G
L
P
K
G
A
K
N
R
Q
N
A
I
N
W
L
R
L
V
-
G
S
K
E
G
Q
D
T
S
N
P
L
K
G
--------------------------------------------------------------------
S
------
I
A
A
-
R
-
L
-
D
S
-
D
-
P
S
K
Y
N
A
-
Y
------
G
Q
S
A
----
M
-
R
-
D
W
R
-
S
N
R
I
V
G
S
-
L
V
-----
H
---
G
----
A
----------------------
V
A
P
E
S
F
M
S
Q
F
G
T
V
M
E
I
F
L
Q
T
R
N
P
-
Q
A
A
A
N
A
A
Q
A
I
A
D
Q
V
G
L
G
R
L
--
37
HHSearch
33.91
18%
56
- C1 -
-
5G5Y
1
?
B:
[2-494]
--------------------------------------------------------------
P
K
T
L
K
F
M
T
A
S
S
P
-
L
-
S
--
P
K
D
P
N
E
K
L
I
L
Q
R
L
E
-
K
E
T
G
V
H
I
D
W
T
N
Y
-
Q
--
S
D
F
A
E
K
R
N
L
D
I
S
S
G
D
L
P
D
A
I
H
----
N
D
G
ASDV
D
L
M
N
W
A
K
K
G
V
I
I
P
V
E
D
L
I
D
K
Y
M
P
N
L
K
K
I
L
D
EK-
P
---
E
Y
K
A
L
M
T
A
-
P
D
G
H
I
Y
S
F
P
W
I
-
E
E
---
L
G
DGKESIHS
V
N
D
M
A
W
I
N
K
D
W
L
K
K
L
G
L
E
M
--
P
K
T
T
D
D
L
I
K
V
L
E
A
F
K
N
G
D
P
N
GNGEAD--
E
------
I
P
F
S
F
I
S
G
--
N
G
-
N
ED
F
K
F
L
F
-
A
A
--
F
--
G
---
I
G
D
ND
D
----------
H
L
V
--
V
G
N
D
G
K
V
D
F
T
A
D
N
D
N
Y
K
E
G
V
K
F
I
R
Q
L
Q
E
K
G
L
I
D
K
E
A
F
E
H
D
----
W
-----
N
------
S
YIA
K
G
H
D
Q
K
F
-
G
V
Y
F
--
T
--
W
D
K
N
N
V
--------
T
G
-
S
--
N
E
S
Y
D
V
L
P
V
L
A
G
PS
G
-
Q
-
K
H-----
V
-------
A
RTNGM--
G
--
F
A
R
D
---
K
M
V
I
T
S
V
N
K
N
L
E
L
T
A
K
W
I
D
A
Q
Y
A
P
-
L
Q
S
V
Q
N
N
W
G
T
Y
G
D
D
K
Q
Q
N
IFEL
D
Q
A
S
N
S
L
K
H
L
P
L
-
N
G
TA
P
--
A
E
---
L
R
Q
KTEV
G
-
G
P
--
L
---
A
-
I
-
L
-------
D
S
Y
Y
------
G
K
V
-
T
T
M
-
P
D
D
A
-
K
W
R
L
D
L
-
I
------
K
E
Y
Y
VPYM
S
-
N
-
V
N
N
-
Y
P
---
R
V
-
F
M
-----
T
---
Q
EDLD
K
I
A
H
I
E
A
D
M
N
D
Y
I
Y
R
K
R
A
E
W
I
--
V
N
G
-
N
I
D
T
E
W
D
D
Y
K
K
E
L
E
K
Y
G
-
L
-
S
D
Y
L
A
I
K
Q
K
Y
Y
D
Q
Y
Q
A
N
K
N
--
39
HHSearch
32.94
19%
16
* C1 *
-
3VXC
1
?
A:
[38-355]
----------------------------------------------------------------
T
I
T
A
M
V
Y
G
D
D
A
V
-
K
--
V
Q
D
K
A
A
S
R
F
N
A
S
A
E
A
K
K
A
N
A
K
V
K
M
E
R
I
-
P
-
A
S
D
Y
P
A
K
L
R
T
A
M
G
S
P
N
A
P
D
I
F
F
----
N
W
G
GG--
S
I
K
A
Y
K
E
A
G
Q
L
V
D
L
T
D
V
I
K
S
D
E
-
V
L
S
T
G
F
L
---
P
---
S
V
V
A
A
G
-
S
-
L
D
G
H
E
Y
G
I
P
M
R
G
M
Q
--------------
P
V
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
T
P
--
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
G
----------
V
------
T
P
F
A
L
G
G
V
EI
W
P
-
E
--
L
M
W
L
E
-
Y
L
--
V
D
-
R
---
I
G
G
--
P
----------
Q
V
F
D
K
-
I
R
N
G
D
A
-
S
G
W
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
V
D
E
G
A
F
G
K
G
F
S
S
V
S
----
Y
NNG
G
A
P
------
A
---
L
L
A
K
G
K
A
-
G
M
H
L
--
M
G
S
W
E
Y
S
T
Q
--
L
G
K
--
F
P
D
F
A
K
K
D
L
G
W
C
A
F
P
S
F
E
G
--
G
-
A
G
D
I-----
R
-------
N
-------
V
V
G
N
P
C
N
---
Y
W
S
V
N
A
R
T
G
N
K
D
G
A
I
A
F
L
R
D
C
A
S
E
A
Y
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------