@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0090: (2017-12-15 )
MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSLGVLTSLPLLMFTLFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLMVGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGLILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFYTVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVSLAGVIGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGLSQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL
Atome Classification :
(20 SA)
------------------.........10.-.......20........30..-..------.------.----.--------.--------------40-------------.........50........60.......-.70.....---...80........90------------------.-----.------------.-.-------.------....100...---....110.......120.-.---.....130.......140.......150---------.-----.--------------------------.--------------..-------------..160.......170......---.----------..-180.--------.--------.-------.-.----.-------------------------------.--190---------------------------------------------------.--.-----.----...----...200--.....----------....210....-----...------220.....-.-..230.----...----.----------....---240.......250.......260.......----270--.......--..280......-----.--------290-----.....-.---...300.......310.......320-------.....-----------------....-330.......-340.-.....-.350..------...-..360.......370.....----------..380-----......--------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------MKKQ
S
L
F
FVPG
I
-
I
L
I
G
V
SLRTP
F
T
V
L
P
I
I
L
GNI-SQ------G------
L
----
E
--------
V
--------------
E
--------------
V
S
SL
G
V
L
T
S
L
P
L
L
M
F
T
LFS
P
F
S
T
Q
L
A
Q
K
-
I
G
L
E
H
L
F
T
---
Y
S
L
F
F
L
T
I
G
S
L
I
R
L
-------------------I-----N------------
L
-
P
-------
L
------
L
Y
L
G
T
L
M
VG
A
---
S
V
A
V
I
N
V
L
L
P
S
L
I
QANQP-K---K
I
G
F
L
T
T
L
Y
V
TS
M
G
I
A
T
A
L
A
S
Y
L
AVPIT---------Q-----A--------------------------S--------------SW-------------
K
G
L
I
L
L
L
T
L
L
C
L
A
--
T
F
L
V
WL---P----------NH-RYNH--------R--------L-------A-P----Q-------------------------------T--K-----------------------------------------------------
Q
--
K
-----
S
----
Q
I
K
----
V
M
RN----K
Q
V
W
A
----------
I
I
I
F
S
G
F
Q
S
L
I
-----
F
Y
T
------
V
M
-
T
WLPT-
M
-
S
I
H--A----GLS----S----------
H
E
A
G
---
L
L
T
S
I
L
S
L
ISIPFSMTIPSLTTSLSTRN
R
Q
----
L
----
M
L
T
L
V
S
L
--
A
G
V
I
G
I
S
M
L
F
F
-----
P
--------
I
-------
N
N
F
I
Y
-
W
---
L
A
I
H
L
L
I
G
T
A
T
S
A
L
F
P
Y
L
M
V
N
F
S
L---------KTSAP-----------------E
K
T
A
-
Q
LSGLSQTG
G
-
Y
I
L
A
-AFGPT-LFG
Y
S
F
------
D
L
F
-
H
S
W
V
P
S
V
A
A
L
L
L
I
D
I
L
M
T
V
A
----------
L
F
T
VD-----RADKIL--------------------------------------------
6
HHSearch
77.98
15%
-128
- C5 -
-
4ZP0
3
MDFA_ECOLI
A:
[4-368]
-------------------
G
R
Q
A
L
L
F
P
L
C
L
-
V
L
Y
E
F
S
T
Y
I
G
N
D
M
I
Q
P
G
M
L
A
V
-
V
E
------
Q
------
Y
----
Q
--------
A
--------------
G
--------------
I
D
W
V
P
T
S
M
T
A
Y
L
A
G
G
M
F
L
Q
W
L
L
G
P
L
S
D
R
-
I
G
R
R
P
V
M
L
---
A
G
V
V
W
F
I
V
T
C
L
A
I
L
L
------------------
A
-----
Q
N-----------
I
-
E
-------
Q
------
F
T
L
L
R
F
L
Q
G
I
---
S
L
C
F
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
A
---
V
C
I
K
I
T
A
L
M
A
N
V
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
---------
H
-----
V
--------------------------
L
--------------
P
W
-------------
E
G
M
F
V
L
F
A
A
L
A
A
I
--
S
F
F
G
L
Q
---
R
----------
A
M
-
P
E
T
A
--------
T
--------
R
I------
G
-
E
----
K
L
S
L
K
---------------------------
E
--
L
-----------------------------------------------------
G
--
R
-----
D
----
Y
K
L
----
V
L
K
N
----
G
R
F
V
A
----------
G
A
L
A
L
G
F
V
S
L
P
-----
L
L
A
------
W
I
-
A
Q
S
P
I
-
I
-
I
I
T
G-
E
----
Q
L
S
----
S
----------
Y
E
Y
G
---
L
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
L
L
A
R
L
T
S
R
R
T
-
V
R
S
-----
L
----
I
I
M
G
G
-
W
--
P
I
M
I
G
L
L
V
A
A
A
A
----
T
V
I
S-----
S
-------
H
A
Y
L
W
-
M
---
T
A
G
L
S
I
Y
A
F
G
I
G
L
A
N
A
G
L
V
-
R
L
T
L
---------
F
A
-
S
D
-----------------
M
S
K
G
-
T
V
S
A
A
M
G
M
L
Q
-
M
L
I
F
-
T
V
G
I
E
-
I
S
K
H
A
W
------
L
N
G
-
G
-----------------------------------------------------------------------------------------
21
HHSearch
76.66
17%
-138
- C5 -
-
4U4T
7
NARK_ECOLI
A:
[52-448]
-----------------------------------------
W
M
L
F
S
A
V
A
V
N
L
P
K
V
------
G
------
F
----
N
--------
F
--------------
T
--------------
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
-
F
G
G
R
R
W
T
A
---
F
S
T
G
I
L
I
I
P
C
V
W
L
G
F
------------------
A
V
Q
D
TS
T
P-----------
Y
-
S
-------
V
------
F
I
I
I
S
L
L
C
G
F
---
A
G
A
N
-
F
A
S
S
M
A
N
I
S
F
F
F
P
K
Q
---
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
A
P
L
V
V
---------
S
LSIFA
V
--------------------------
F
--------------
G
S
Q
G
V
K
Q
PDGTELY
L
A
N
A
S
W
I
W
V
P
F
L
A
I
--
F
T
I
A
A
W
---
F
----------
G
M
-
N
D
L
A
--------
T
------------------------------------------------------------------------------------------------------------------------------
Q
L
P
----
V
L
K
R
----
G
H
L
W
I
----------
M
S
L
L
Y
L
A
T
F
G
S
-----
F
I
G
------
F
S
-
A
G
F
A
M
-
L
-
S
K
---
T
----
Q
F
P
----
D
----------
V
Q
I
L
---
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
-
G
T
R
-----
V
----
T
L
V
N
F
-
I
--
L
M
A
I
F
S
G
L
L
F
L
TLPT-
D
--------
G
QG-----
G
S
F
M
A
F
F
A
V
F
L
A
L
F
L
T
A
G
L
G
S
G
S
T
F
Q
M
I
S
V
I
F
R
K
---------
L
T
-
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
-
A
A
L
G
F
I
S
A
I
G
-
A
I
G
G
-
F
F
I
P
K
-
A
F
G
S
S
L
------
A
L
T
-
G
S
P
V
G
A
M
K
V
F
L
I
F
Y
I
A
--------------------------------------------------------------------------
7
HHSearch
74.10
13%
-141
- C5 -
-
1PW4
-
GLPT_ECOLI
A:
[25-431]
--------------------
R
L
R
W
Q
I
F
L
G
I
-
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
-------
E
------
Q
----
G
--------
F
--------------
S
--------------
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
-
S
N
P
R
V
F
L
P
---
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
------------------
V
P
W
A
T
S
S
------------
I
-
A
-------
V
------
M
F
V
L
L
F
L
C
G
W
---
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
---
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
---------
A
-----
W
F-------------------------
N
--------------
D
W
-------------
H
A
A
L
Y
M
P
A
F
C
A
I
L
--
V
A
L
F
A
F
---
A
----------
M
M
-
R
D
T
P
--------
Q
--------
S
CGLPPIE
E
-
Y
----
K
ND------------------------------------------------------------------------------------------TAK
Q
I
F
----
M
Q
Y
----
V
L
P
N
----
K
L
L
W
Y
----------
I
A
I
A
N
V
F
V
Y
L
L
-----
R
Y
G
------
I
L
-
D
W
S
P
T
-
Y
-
L
K
E
--
V
K---
H
F
A
----
L
----------
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
-
R
G
N
-----
R
----
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N----
P
--------
A
-------
G
N
P
T
V
-
D
---
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
---------
L
A
-
P
K
-----------------
K
A
A
G
-
T
A
A
G
F
T
G
L
F
G
-
Y
L
G
G
S
V
A
A
S
A
-
I
V
G
Y
T
V
------
D
F
F
-
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
----------
L
-----------------------------------------------------------
22
HHSearch
74.08
17%
-137
- C5 -
-
4U4V
6
NARK_ECOLI
A:
[52-448]
-----------------------------------------
W
M
L
F
S
A
V
A
V
N
L
P
K
V
------
G
------
F
----
N
--------
F
--------------
T
--------------
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
P
I
-
F
G
G
R
R
W
T
A
---
F
S
T
G
I
L
I
I
P
C
V
W
L
G
F
------------------
A
V
Q
D
TS
T
P-----------
Y
-
S
-------
V
------
F
I
I
I
S
L
L
C
G
F
---
A
G
A
N
-
F
A
S
S
M
A
N
I
S
F
F
F
P
K
Q
---
K
Q
G
G
A
L
G
L
N
G
G
L
G
N
M
G
V
S
V
M
Q
L
V
A
P
L
V
V
---------
S
LSIFA
V
--------------------------
F
--------------
G
S
Q
G
V
K
Q
PDGTELY
L
A
N
A
S
W
I
W
V
P
F
L
A
I
--
F
T
I
A
A
W
---
F
----------
G
M
-
N
D
L
A
--------
T
-------------------------------------------------------------------------------------------------------------------------------
L
P
----
V
L
K
R
----
G
H
L
W
I
----------
M
S
L
L
Y
L
A
T
F
G
S
-----
F
I
G
------
F
S
-
A
G
F
A
M
-
L
-
S
K
---
T
----
Q
F
P
----
D
----------
V
Q
I
L
---
Q
Y
A
F
F
G
P
F
I
G
A
L
A
R
S
A
G
G
A
L
S
D
R
L
G
-
G
T
R
-----
V
----
T
L
V
N
F
-
I
--
L
M
A
I
F
S
G
L
L
F
L
T
LPT-
D
---------QG-----
G
S
F
M
A
F
F
A
V
F
L
A
L
F
L
T
A
G
L
G
S
G
S
T
F
Q
M
I
S
V
I
F
R
K
---------
L
T
-
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
A
T
D
T
A
-
A
A
L
G
F
I
S
A
I
G
-
A
I
G
G
-
F
F
I
P
K
-
A
F
G
S
S
L
------
A
L
T
-
G
S
P
V
G
A
M
K
V
F
L
I
F
Y
I
A
--------------------------------------------------------------------------
23
HHSearch
72.28
14%
-141
- C5 -
-
4GBY
5
XYLE_ECOLI
A:
[9-458]
---------------------
Y
I
F
S
I
T
L
V
A
-
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
T
------
V
------
F
----
V
APQNLS
E
S
A
--------------
A
--------------
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
G
R
R
D
S
L
K
---
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVYL
A
-----
G
Y-----------
V
-
P
-------
E
------
F
V
I
Y
R
I
I
G
G
I
---
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
---
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
---------
R
-----
S
GD
A
S
W
L
N
T
------------------
D
--------------
G
W
-------------
R
Y
M
F
A
S
E
C
I
P
A
L
L
--
F
L
M
L
L
Y
---
T
----------
V
P
-
E
S
P
R
--------
W
--------
L
M
S
-----
R
-
G
----
K
Q
------------------------------
E
--
Q
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
------------------------------------
V
--
Q
-----
E
I
K
H
S
L
D
H
----
G
R
K
T
----
G
G
R
L
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-----
I
N
V
------
V
L
-
Y
Y
A
P
E
-
V
-
F
K
T
--
L
----
G
A
S
----
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
-
R
K
P
-----
L
----
Q
I
I
G
A
-
L
--
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
--
T
Q-------
A
-------
P
G
I
V
A
-
L
---
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
---------
I
F
-
P
N
-----------------
A
I
R
G
-
K
A
L
A
I
A
V
A
A
Q
-
W
L
A
N
-
Y
F
V
S
W
-
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
-
H
-
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
----------------------------------------------------------------------
28
Fugue
71.62
18%
-100
- C5 -
-
3WDO
-
?
A:
[3-455]
---------------DYK
M
T
P
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
-
M
A
------
L
------
Q
----
G
--------
A
--------------
S
--------------
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
-
I
G
R
K
P
L
I
V
---
G
G
L
A
V
F
A
A
G
S
V
I
A
A
-------------------
L
SD---
S
------------
I
-
W
-------
G
------
I
I
L
G
R
A
L
Q
G
S
G
AI
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
-
K
---
A
M
A
F
I
G
V
----
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
---------
H
-----
K
--------------------------
L
--------------
G
L
-------------
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
---
V
----------
P
N
-
S
S
T
H
--------
V
--------
L
-------
N
-
R
----
E
-------------------------------
S
GM
V
-----------------------------------------------------
K
--
G
-----
S
----
F
S
K
----
V
L
A
E
----
P
R
L
L
K
----------
L
N
F
G
I
M
C
L
H
M
L
-----
L
M
S
------
T
F
-
V
A
L
P
G
-
Q
-
L
A
D
--
A
----
G
F
P
----------------
A
A
E
---
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
----
Q
----
V
F
V
F
C
-
V
--
G
L
I
V
V
A
E
I
V
L
W
-----
N
--------
A
-------
Q
T
Q
F
W
-
Q
---
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
---------
K
E
S
P
A
-----------------
G
Y
K
G
-
T
A
M
G
V
Y
S
T
S
Q
-
F
L
G
V
-
A
I
G
G
S
-
L
G
G
W
I
D
------
G
M
F
-
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
MKEPP
Y
V
S
S
L
R
I
E
IPADI
A
A
N
E
A
L
K
V
R
L
L
E
TEGVK
E
V
L
I
AEEEH
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL
24
HHSearch
70.25
14%
-142
- C5 -
-
4GC0
5
XYLE_ECOLI
A:
[9-458]
---------------------
Y
I
F
S
I
T
L
V
A
-
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
T
------
V
------
F
----
V
APQNLS
E
S
A
--------------
A
--------------
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
G
R
R
D
S
L
K
---
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVYL
A
-----
G
Y-----------
V
-
P
-------
E
------
F
V
I
Y
R
I
I
G
G
I
---
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
---
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
---------
R
-----
S
GD
A
S
W
L
N
T
------------------
D
--------------
G
W
-------------
R
Y
M
F
A
S
E
C
I
P
A
L
L
--
F
L
M
L
L
Y
---
T
----------
V
P
-
E
S
P
R
--------
W
--------
L
M
S
-----
R
-
G
----
K
Q
------------------------------
E
--
Q
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
------------------------------------
V
--
Q
-----
E
----
I
K
H
S
L
D
H
G
R
K
T
----
G
G
R
L
L
M
F
GVG
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-----
I
N
V
------
V
L
-
Y
Y
A
P
E
-
V
-
F
K
T
--
L
----
G
A
S
----
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
-
R
K
P
-----
L
----
Q
I
I
G
A
-
L
--
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
--
T
Q-------
A
-------
P
G
I
V
A
-
L
---
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
---------
I
F
-
P
N
-----------------
A
I
R
G
-
K
A
L
A
I
A
V
A
A
Q
-
W
L
A
N
-
Y
F
V
S
W
-
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
-
H
-
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
----------------------------------------------------------------------
30
Fugue
69.37
15%
-128
* C5 *
-
4QIQ
-
XYLE_ECOLI
A:
[7-470]
---------S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
-
A
V
I
S
G
T
V
E
S
L
N
T
V
F
---
V
A
P
Q
-
N
L
------
S
------
E
----
S
--------
A
--------------
A
--------------
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
-
F
G
R
R
D
S
L
K
---
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTS-----------
I
-----
N
PDNTVPVYLAGY
V
-
P
-------
E
------
F
V
I
Y
R
I
I
G
G
I
---
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
-
A
---
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
SGD
A
S
W
L
N
-----
T
--------------------------
D
--------------
G
W
-------------
R
Y
M
F
A
S
E
C
I
P
A
L
L
--
F
L
M
L
L
Y
T
VP
E
----------
S
P
-
R
W
L
M
--------
T
--------
L
-------
A
-
T
----
Q
-------------------------------
A
--
V
-----------------------------------------------------
Q
--
E
-----
I
----
K
H
S
----
L
D
R
L
----
L
M
F
G
V
----------
G
V
I
V
I
G
V
M
L
S
I
-----
F
Q
Q
F
V
G
I
N
V
V
L
-
Y
Y
A
P
E
-
V
-
F
K
T
--
L
----
G
A
S
----
T
----------
D
I
A
L
---
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
----
I
----
I
G
A
L
G
M
A
--
I
G
M
F
S
L
G
T
A
F
Y
T
----
Q
--------
A
-------
P
G
I
V
A
-
L
---
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
PNA
I
R
G
K
A
L
A
I
A
-----------------
V
A
A
Q
-
W
L
A
N
Y
F
V
S
W
T
-
F
P
M
M
-
D
K
N
S
W
-
L
V
A
H
F
H
------
N
G
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
----------
P
E
T
K
G
-----
K
T
L
-----------------------------------------------
26
Fugue
69.33
11%
-119
- C5 -
-
1PW4
-
GLPT_ECOLI
A:
[5-451]
FKPAPHKARLPAAEI
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
-
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-
V
E
-------------
Q
----
G
--------
F
--------------
S
--------------
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
-
S
N
P
R
V
F
L
P
---
A
G
L
I
L
A
A
A
V
M
L
F
M
G
-------------------
F
-----
V
------------
P
-
W
-------
A
T
S
SIAV
M
F
V
L
L
F
L
C
G
W
---
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
---
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
---------
A
-----
W
F-------------------------
N
--------------
D
W
-------------
H
A
A
L
Y
M
P
A
F
C
A
I
L
--
V
A
L
F
A
F
---
A
M
MRDTPQSCG
L
P
-
P
I
E
E
--------
Y
--------
K
-------
N
-
D
----
T
-------------------------------
A
--
K
-----------------------------------------------------
Q
--
I
-----
F
----
M
Q
Y
----
V
L
P
N
----
K
L
L
W
Y
----------
I
A
I
A
N
V
F
V
Y
L
L
-----
R
Y
G
------
I
L
-
D
W
S
P
T
Y
L
-
K
E
V
--
K
----
H
F
A
----
L
----------
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
----
A
----
T
G
V
F
F
M
T
--
L
V
T
I
A
T
I
V
Y
W
M
-----
N
--------
P
-------
A
G
N
P
T
-
V
---
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
---------
E
L
A
P
K
-----------------
K
A
A
G
-
T
A
A
G
F
T
G
L
F
G
-
Y
L
G
G
-
S
V
A
A
S
-
A
I
V
G
Y
T
------
V
D
F
-
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
----------
L
I
V
V
M
-----
I
G
E
K
R
R
H
E
Q
LLQELVP----------------------------------
25
HHSearch
68.17
12%
-107
- C5 -
-
5EQH
1
GTR1_HUMAN
A:
[13-430]
-----------------------
M
L
A
V
G
G
A
-
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
-
E
E
------
F
------
Y
----
N
--------
Q
--------------
T
W
V
H
R
YGESIL
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
-
F
G
R
R
N
S
M
L
---
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
------------------
S
KLG--
K
S-----------
F
-
E
-------
M
------
L
I
L
G
R
F
I
I
G
V
---
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
---
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
MG-------
N
-----
K
--------------------------
D
--------------
L
W
-------------
P
L
L
L
S
I
I
F
I
P
A
L
L
--
Q
C
I
V
L
P
---
F
----------
C
P
-
E
S
P
R
--------
F
L
L
INRN--
E
-------
E
-
N
----
R
A
K
S
V
L
K
K
L
RGTADV
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R-
E
--
K
-----------------------------------------------------
K
--
V
-----
T
----
I
L
E
----
L
F
R
S
----
P
A
Y
R
Q
----------
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
LSG
I
N
A
------
V
F
-
Y
Y
S
T
S
-
I
-
F
E
K
--
A
----
G
------
V
----------
Q
Q
P
V
---
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
E
R
A
G
-
R
R
T
-----
L
----
H
L
I
G
L
-
A
--
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
--------
Q
LPW----
M
S
Y
L
S
-
I
---
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
---------
L
F
-
S
Q
-----------------
G
P
R
P
-
A
A
I
A
V
A
G
F
S
N
-
W
T
S
N
-
F
I
V
G
M
-
C
F
Q
Y
V
E
------
Q
L
C
-
G
-----------------------------------------------------------------------------------------
20
HHSearch
67.69
10%
-139
- C5 -
-
4J05
-
?
B:
[33-501]
----------------------
Q
I
K
L
V
L
L
A
-
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
-
A
Q
------
V
------
Y
FPKT
G
--------
L
--------------
P
--------------
A
Q
R
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
-
F
G
R
K
F
V
Y
G
---
K
E
L
I
L
I
I
V
A
T
I
F
Q
M
S------------------
A
-----
P
S-----------
H
-
W
DGNRVLT
W
------
I
T
I
C
R
V
F
L
G
I
---
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
---
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
S
F
V
G
S
L
V
T
I
V
T
I
---------
S
-----
G
--------------------------
F
KHRLKSGHTHDVDK
A
W
-------------
R
I
L
I
G
L
S
L
I
P
A
F
G
--
T
L
Y
Q
R
-----------------------------------------------------------------------------------------------------------------------------------------------
W
--
Q
-----
E
----
F
V
A
----
Y
F
S
T
WNHF
R
N
L
L
G
----------
S
M
L
G
W
F
L
V
D
I
A
-----
F
Y
G
------
I
N
-
L
N
Q
S
V
-
V
-
L
A
Q
--
I
----
G
F
A
----
G
KTGDVYDKLF
Q
L
A
T
---
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
V
G
-
R
K
K
-----
L
----
Q
F
M
G
F
-
I
--
M
S
G
L
F
L
A
I
L
A
G
EI---
D
H-------
I
-------
G
K
G
P
L
-
L
---
A
C
F
T
F
M
Q
F
F
F
N
F
G
A
N
T
T
T
F
I
V
A
A
E
---------
L
F
-
P
T
-----------------
R
I
R
A
-
S
A
H
G
I
S
A
A
A
G
-
K
C
G
A
-
I
L
S
S
L
-
V
F
N
Q
L
K
------
A
K
I
-
G
-
T
S
A
V
L
W
I
F
F
S
T
C
I
L
G
F
I
S
----------
T
F
L
I
--------------------------------------------------------
16
HHSearch
65.13
15%
-114
- C5 -
-
3WDO
-
?
A:
[28-388]
-----------------------------------------
M
F
M
V
L
P
V
L
T
T
Y
-
G
M
A-----
L
------
Q
----
G
--------
A
--------------
S
--------------
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
-
I
G
R
K
P
L
I
V
---
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
------------------
S
-----
D
S-----------
I
-
W
-------
G
------
I
I
L
G
R
A
L
Q
G
S
---
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
---
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
---------
H
-----
K
--------------------------
L
--------------
G
L
-------------
H
A
L
F
W
M
I
A
I
L
A
T
T
--
G
I
A
L
T
I
---
W
----------
V
V
-
P
N
S
S
--------
T
--------
H
-------
V
-
L
----
N
R
E
SG---------------------------
M
--
V
-----------------------------------------------------
K
--
G
-----
S
----
F
S
K
----
V
L
A
E
----
P
R
L
L
K
----------
L
N
F
G
I
M
C
L
H
M
L
-----
L
M
S
------
T
F
-
V
A
L
P
G
-
Q
-
L
A
D
--
A
----
G
F
P
----
A
----------
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
-
Q
V
F
----------
V
F
C
V
G
-
L
--
I
-
V
V
A
E
I
V
L
W
N
A----
Q
--------
T
-------
Q
F
W
Q
L
-
V
----
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
---------
E
S
-
P
A
-----------------
G
Y
K
G
-
T
A
M
G
V
Y
S
T
S
Q
-
F
L
G
V
-
A
I
G
G
S
-
L
G
G
W
I
D
------
G
M
F
-
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
----------
A
S
T
M
--------------------------------------------------------
29
Fugue
64.95
11%
-158
- C5 -
-
2GFP
-
EMRD_ECOLI
A:
[9-383]
---------------------
L
L
L
M
L
V
L
L
V
-
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
-----
R
------
D
------
L
----
N
--------
V
--------------
R
--------------
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
-
V
G
R
R
P
V
I
L
---
V
G
M
S
I
F
M
L
A
T
L
V
A
V
-------------------
T
-----
T
------------
S
-
S
-------
L
TVL---
I
A
A
S
A
M
Q
G
M
G
---
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
-
T
---
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
---------
T
-----
M
--------------------------
W
--------------
N
W
-------------
R
A
C
Y
L
F
L
L
V
L
C
A
G
--
V
T
F
S
M
A
---
R
----------
W
M
-
P
E
T
R
--------
P
--------
V
-------
D
-
A
----
P
-------------------------------
R
--
T
-----------------------------------------------------
R
LL
T
-----
S
----
Y
K
T
----
L
F
G
N
----
S
G
F
N
C
----------
Y
L
L
M
L
I
G
G
L
A
G
-----
I
A
A
------
F
E
-
A
C
S
G
V
-
L
M
G
A
V
--
L
----
G
L
S
----
S
----------
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
----
S
----
V
I
C
C
L
L
A
--
G
L
L
M
W
I
P
D
W
F
G
-----
V
--------
M
-------
N
V
W
T
L
-
L
---
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
------------
P
F
P
-----------------
F
L
A
G
-
T
A
G
A
L
V
G
G
L
Q
-
N
I
G
S
-
G
V
L
A
S
-
L
S
A
---------------
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
----------
L
L
I
V
L
-----
C
W
L
P
L
---------------------------------------------
4
HHSearch
64.90
11%
-133
- C5 -
-
3O7Q
1
FUCP_ECOLI
A:
[42-435]
-----------------------------------------
N
N
L
N
D
I
L
L
P
Q
F
-
Q
Q
------
A
------
F
----
T
--------
L
--------------
T
--------------
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
-
L
S
Y
K
A
G
I
I
---
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
------------------
A
A
E
I
--
M
N-----------
Y
-
T
-------
L
------
F
L
V
G
L
F
I
I
A
A
---
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
---
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
---------
L
-----
S
NVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
--------------
S
V
-------------
Q
T
P
Y
M
I
I
V
A
I
V
L
L
--
V
A
L
L
I
M
---
L
----------
T
K
F
P
A
L
Q
--------
S
--------
D
-------
N
H
S
----
D
AKQG---------------------------
S
--
F
-----------------------------------------------------
S
--
A
-----
S
----
L
S
R
----
L
A
R
I
----
R
H
W
R
W
----------
A
V
L
A
Q
F
C
Y
V
G
A
-----
Q
T
A
------
C
W
-
S
Y
L
I
R
-
Y
-
A
V
E
--
E
IP--
G
M
T
----
A
----------
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
-
P
H
K
-----
V
----
L
A
A
Y
A
-
L
--
I
A
M
A
L
C
L
I
S
A
F
-----
A
--------
G
-------
G
H
-
V
G
-
L
----
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
---------
N
L
G
Q
D
-----------------
T
K
Y
G
---
S
S
F
I
-
V
M
T
-
I
I
G
G
-
G
I
V
T
P
-
V
M
G
F
V
S
------
D
A
A
-
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
----------
A
R
F
R
S
-----
Q
T
------------------------------------------------
8
HHSearch
62.66
12%
-150
- C5 -
-
2GFP
-
EMRD_ECOLI
A:
[24-377]
-----------------------------------------
Q
T
I
Y
I
P
A
I
A
D
M
-
A
R
------
D
------
L
----
N
--------
V
--------------
R
--------------
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
-
V
G
R
R
P
V
I
L
---
V
G
M
S
I
F
M
L
A
T
L
V
A
V
T
------------------
T
-----
S
S-----------
L
-
T
-------
V
------
L
I
A
A
S
A
M
Q
G
M
---
G
T
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
---
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
---------
T
-----
M
--------------------------
W
--------------
N
W
-------------
R
A
C
Y
L
F
L
L
V
L
C
A
G
--
V
T
F
S
M
A
---
R
----------
W
M
-
P
E
T
R
--------
P
--------
V
-------
D
A
P
R
---
T
-------------------------------
R
--
L
-----------------------------------------------------
L
--
T
-----
S
----
Y
K
T
----
L
F
G
N
----
S
G
F
N
C
----------
Y
L
L
M
L
I
G
G
L
A
G
-----
I
A
A
------
F
E
-
A
C
S
G
V
-
L
-
M
G
A
--
V
L
---
G
L
S
----
S
----------
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
-
T
L
M
-----
W
----
Q
S
V
I
C
-
C
--
L
L
A
G
L
L
M
W
I
P
D
W
----
F
G
-------
V
-------
M
N
V
W
T
-
L
---
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
---------
P
F
-
P
------------------
F
L
A
G
-
T
A
G
A
L
V
G
G
L
Q
-
N
I
G
S
-
G
V
L
A
S
-
L
S
A
M
L
P
------
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
---------------------------------------------------------------------------
15
HHSearch
62.16
12%
-109
- C5 -
-
4ZW9
4
GTR3_HUMAN
A:
[30-451]
--------------------
P
A
L
I
F
A
I
T
V
A
-
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
-
K
E
------
F
------
I
----
T
--------
K
T
L
T
D
K
GNAPPS
E
V
L
L
--------------
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
-
F
G
R
R
N
S
M
L
---
I
V
N
L
L
A
V
T
G
G
C
F
M
G
L
CKV---------------
A
-----
K
S-----------
V
-
E
-------
M
------
L
I
L
G
R
L
V
I
G
L
---
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
---
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
LG-------
S
-----
E
--------------------------
E
--------------
L
W
-------------
P
L
L
L
G
F
T
I
L
P
A
I
L
--
Q
S
A
A
L
P
---
F
----------
C
P
-
E
S
P
R
--------
F
--------
L
L
INR---
K
E
E
----
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
--
K
-----------------------------------------------------
Q
--
V
-----
T
----
V
L
E
----
L
F
R
V
----
S
S
Y
R
Q
----------
P
I
I
I
S
I
V
L
Q
L
S
-----
Q
Q
L
------
S
G
I
N
A
V
F
Y
-
Y
-
S
T
G
I
F
K
----
D
A
G
----
V
----------
Q
E
P
I
---
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
-
R
R
T
-----
L
----
H
M
I
G
L
-
G
--
G
M
A
F
C
S
T
L
M
T
V
-----
S
L
L
L
KDNY
N
G
-------
M
S
F
V
C
-
I
---
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
---------
L
F
-
S
Q
-----------------
G
P
R
P
-
A
A
M
A
V
A
G
C
S
N
-
W
T
S
N
-
F
L
V
G
L
-
L
F
P
S
A
A
------
H
Y
L
-
G
A
----------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.97
21%
-161
- C5 -
-
1PW4
-
GLPT_ECOLI
A:
[249-439]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
P
N
----
K
L
L
W
Y
----------
I
A
I
A
N
V
F
V
Y
L
L
-----
R
Y
G
------
I
L
-
D
W
S
P
T
Y
L
-
K
E
V
--
K
----
H
F
A
----
L
----------
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
----
F
M
T
L
V
T
I
--
A
T
I
V
---
Y
W
M
N
-----
P
--------
A
-------
G
N
P
T
V
-
D
---
M
I
C
M
I
V
I
G
F
L
I
Y
G
--
P
V
M
L
I
G
L
H
A
---------
L
E
L
A
P
-----------------
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
-
Y
L
G
G
-
S
V
A
A
S
A
I
V
G
Y
T
V
------
D
F
F
--
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
----------
L
I
V
V
M
-----
I
G
E
K
----------------------------------------------
14
HHSearch
60.15
11%
-130
- C5 -
-
4IKY
8
?
A:
[39-480]
-----------------------------------------
Y
Y
G
M
R
A
I
L
V
Y
Y
-
M
Y
YEVSKG
G
------
L
----
G
--------
L
--------------
D
--------------
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
---
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
I
------------------
P
-----
G
G-----------
V
-
A
-------
A
------
L
F
V
S
M
A
L
I
V
L
---
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
-
P
GDD
R
R
D
A
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
L
A
P
L
V
V
G
T
A
G
---------
M
-----
K
--------------------------
Y
--------------
N
F
-------------
H
L
G
F
G
L
A
A
V
G
M
F
L
--
G
L
V
V
F
V
---
A
----------
T
R
-
K
K
N
L
GLAGTYVP
N
--------
P
-------
L
-
T
----
P
A
E
K
----------------------------
K
--
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
NGWFT
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
SP
K
--
T
-----
T
----
A
E
E
----
R
S
R
V
----
I
A
Y
I
P
----------
L
F
V
A
S
A
M
F
W
A
I
-----
Q
Q
Q
------
G
S
-
T
I
L
A
N
-
Y
-
A
D
K
--
R
T---
Q
L
D
VAG
I
H
----------
L
S
P
A
---
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
-
K
R
Q
-----
P
T
I
P
Q
K
F
A
L
G
L
L
--
F
A
G
L
S
F
I
V
I
L
V
P
----
G
--------
H
L
S
GGGLV
H
P
-
I
W
-
L
---
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
---------
L
A
P
-
A
-----------------
A
F
S
A
-
Q
T
M
S
L
W
F
L
S
N
-
A
A
A
Q
-
A
I
N
A
Q
-
L
V
R
F
Y
T
------
P
E
N
---
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
----------------------------------------------------------------------
19
HHSearch
59.94
11%
-131
- C5 -
-
4IKV
9
?
A:
[39-480]
-----------------------------------------
Y
Y
G
M
R
A
I
L
V
Y
Y
-
M
Y
------
Y
EVSKGG
L
----
G
--------
L
--------------
D
--------------
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
D
R
V
F
G
T
S
R
A
V
F
---
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
I
------------------
P
-----
G
G-----------
V
-
A
-------
A
------
L
F
V
S
M
A
L
I
V
L
---
G
T
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
K
-
P
GDD
R
R
D
A
G
F
S
I
F
Y
M
G
I
N
L
G
A
F
L
A
P
L
V
V
G
T
A
G
---------
M
-----
K
--------------------------
Y
--------------
N
F
-------------
H
L
G
F
G
L
A
A
V
G
M
F
L
--
G
L
V
V
F
V
---
A
----------
T
R
-
K
K
N
L
--------
G
LAGTYVP
N
P
-------
L
-
T
----
P
A
------------------------------
E
K
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
GWFT
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
SP
K
--
T
-----
T
----
A
E
E
----
R
S
R
V
----
I
A
Y
I
P
----------
L
F
V
A
S
A
M
F
W
A
I
-----
Q
E
Q
------
G
S
-
T
I
L
A
N
-
Y
-
A
D
K
--
R
T---
Q
L
D
VAG
I
H
----------
L
S
P
A
---
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
V
K
L
G
-
K
R
Q
-----
P
T
I
P
Q
K
F
A
L
G
L
L
--
F
A
G
L
S
F
I
V
I
L
V
P
----
G
--------
H
L
S
GGGLV
H
P
-
I
W
-
L
---
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
---------
L
A
P
-
A
-----------------
A
F
S
A
-
Q
T
M
S
L
W
F
L
S
N
-
A
A
A
Q
-
A
I
N
A
Q
-
L
V
R
F
Y
T
------
P
E
N
---
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
----------------------------------------------------------------------
12
HHSearch
59.18
12%
-135
- C5 -
-
2CFQ
-
LACY_ECOLI
A:
[23-396]
-----------------------------------------
M
G
A
Y
F
P
F
F
P
I
W
-
L
H
------
D
------
I
N---
H
--------
I
--------------
S
--------------
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
------------------
G
-----
P
L
-----------
L
Q
Y
-------
N
------
I
L
V
G
S
I
V
G
G
I
---
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
-
K
V
S
R
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
---------
T
--------------------------------
I
--------------
N
N
-------------
Q
F
V
F
W
L
G
S
G
C
A
L
I
--
L
A
V
L
L
F
---
F
----------
A
K
-
T
D
A
P
--------
S
--------
S
-------
A
-
T
VANA
V
GAN
H
S
A
-------------------------
F
--
S
-----------------------------------------------------
L
--
K
-----
L
----
A
L
E
----
L
F
R
Q
----
P
K
L
W
F
----------
L
S
L
Y
V
I
G
V
S
C
T
-----
Y
D
V
------
F
D
-
Q
Q
F
A
N
-
F
-
F
T
S
--
F
FAT
G
E
Q
G
----
T
----------
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
-
G
K
N
-----
A
----
L
L
L
-
A
G
T
--
I
M
S
V
R
I
I
G
S
S
F
-----
A
--------
T
-------
S
A
L
E
V
-
V
----
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
---------
Q
F
E
-
V
-----------------
R
F
S
A
-
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
-
L
A
G
N
M
Y
------
E
S
I
-
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
----------
S
-----------------------------------------------------------