@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0100: (2017-12-15 )
MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLLNLLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLMLALKYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLILADEPTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK
Atome Classification :
(30 SA)
.........10-.--...----..--...20........30........40........50........60...---------.....70...-..--...80........90........100.---......110--------.........120.--......130.....-...140.......150.......160.......170.......180..-..-...190....-...200.-.-......210.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MI
E
L
K
N
I
T
K
T
--I--GG
K
----
V
I
--
L
DN
L
S
L
R
IDQG
D
L
V
A
I
V
GKSGS
G
K
S
T
L
L
N
L
L
G
LIDGDYSG
R
Y
E
I
F
GQ
T
---------
N
L
A
VNSA
K
S
Q
-
T
I
--
I
R
E
H
I
S
Y
L
F
Q
N
F
ALIDDET
V
E
Y
N
L
M
L
A
---
L
K
Y
VKLP----------
K
K
D
K
L
K
K
V
E
E
I
L
E
--
R
VGL
S
A
T
L
-
H
Q
R
V
S
-
E
LSGG
E
Q
Q
R
I
A
V
A
R
A
ILKP
S
Q
L
I
L
ADEPTGSLDPE
N
R
D
L
V
L
K
F
L
L
E
MN-RE-G
K
T
V
I
I
V
TH
D
-
A
Y
V
A
Q
-
Q
-
C
-
H
R
V
I
ELGEGK
2
PsiBlast_PDB
94.26
41%
0
- C- -
-
5NIL
-
?
J:
[4-239]
L
L
E
L
K
D
I
R
R
S
--
Y
--
P
A
G
DEQV
E
V
--
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
Q
D
---------
V
A
T
L
D
A
D
A
L
A
-
Q
L
--
R
R
E
H
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
E
V
P
---
A
V
Y
A
G
L
E
----------
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
--
R
L
G
L
E
D
R
T
-
E
Y
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
-
D
R
-
G
H
T
V
I
I
V
T
H
D
-
P
Q
V
A
A
-
Q
-
A
-
E
R
V
I
E
I
R
D
G
E
1
PsiBlast_PDB
94.26
41%
0
- C- -
-
5NIK
-
?
J:
[4-239]
L
L
E
L
K
D
I
R
R
S
--
Y
--
P
A
G
DEQV
E
V
--
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
Q
D
---------
V
A
T
L
D
A
D
A
L
A
-
Q
L
--
R
R
E
H
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
E
V
P
---
A
V
Y
A
G
L
E
----------
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
--
R
L
G
L
E
D
R
T
-
E
Y
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
-
D
R
-
G
H
T
V
I
I
V
T
H
D
-
P
Q
V
A
A
-
Q
-
A
-
E
R
V
I
E
I
R
D
G
E
125
HHSearch
83.04
37%
-111
- C1 -
-
2PCL
5
LOLD_AQUAE
A:
[4-216]
I
L
R
A
E
N
I
K
K
V
--
I
--
R
G
Y
----
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
---------
V
D
Y
T
N
E
K
E
L
S
-
L
L
--
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
---
M
L
K
M
G
K
P
----------
K
K
E
A
K
E
R
G
E
Y
L
L
S
--
E
L
G
L
G
D
K
L
-
S
R
K
P
Y
-
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
E
-
L
-
T
-
H
R
T
L
E
M
K
D
G
K
18
PsiBlast_PDB
79.82
33%
-73
- C1 -
-
4U00
1
?
A:
[4-215]
I
I
R
I
R
N
L
H
K
W
--
F
--
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
D
R
A
L
-
R
E
--
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
--
M
R
V
R
R
W
P
----------
R
E
K
A
E
K
K
A
L
E
L
L
E
--
R
V
G
I
L
D
Q
A
-
R
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
V
A
-
D
R
V
V
F
M
D
G
G
Q
4
PsiBlast_PDB
78.77
37%
-101
- C1 -
-
2PCL
5
LOLD_AQUAE
A:
[8-216]
----
E
N
I
K
K
V
--
I
--
R
G
Y
----
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
---------
V
D
Y
T
N
E
K
E
L
S
-
L
L
--
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
---
M
L
K
M
G
K
P
----------
K
K
E
A
K
E
R
G
E
Y
L
L
S
--
E
L
G
L
G
D
K
L
-
S
R
K
P
Y
-
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
E
-
L
-
T
-
H
R
T
L
E
M
K
D
G
K
19
PsiBlast_PDB
78.57
33%
-71
- C1 -
-
4U02
-
?
A:
[4-215]
I
I
R
I
R
N
L
H
K
W
--
F
--
G
P
L
----
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
D
R
A
L
-
R
E
--
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P--
M
R
V
R
R
W
P
----------
R
E
K
A
E
K
K
A
L
E
L
L
E
--
R
V
G
I
L
D
Q
A
-
R
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
V
A
-
D
R
V
V
F
M
D
G
G
Q
109
HHSearch
77.44
30%
-135
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[4-211]
-
V
Q
L
Q
N
V
T
K
A
--
W
--
G
E
V
----
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
---------
M
N
D
T
P
-------
P
--
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
---
L
K
L
A
G
A
K
----------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
--
V
L
Q
L
A
H
L
L
-
D
R
K
P
K
-
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
-
K
R
L
G
R
T
M
I
Y
V
T
H
D
-
Q
V
E
A
M
T
L
-
A
-
D
K
I
V
V
L
D
A
G
R
60
PsiBlast_CBE
77.42
33%
-121
- C1 -
-
2YYZ
1
?
A:
[4-211]
-
I
R
V
V
N
L
K
K
Y
--
F
--
G
K
V
----
K
A
--
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
--
E
I
Y
F
D
----------
D
V
L
V
N
D
I
P
P
K
-----
Y
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
---
L
R
A
R
R
I
S
----------
K
D
E
V
E
K
R
V
V
E
I
A
R
--
K
L
L
I
D
N
L
L
-
D
R
K
P
T
-
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
-
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
-
M
-
A
-
S
R
I
A
V
F
N
Q
G
K
110
HHSearch
76.49
31%
-122
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[5-215]
-
L
H
I
G
H
L
S
K
S
--
F
--
Q
N
T
----
P
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
---------
I
F
S
K
N
T
N
L
---
P
V
--
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
---
L
G
N
G
K
G
R
----------
T
A
Q
E
R
Q
R
I
E
A
M
L
E
--
L
T
G
I
S
E
L
A
-
G
R
Y
P
H
-
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
-
R
E
E
A
L
Q
Y
-
A
-
D
R
I
A
V
M
K
Q
G
-
3
PsiBlast_PDB
76.43
37%
-98
- C1 -
-
2PCJ
-
LOLD_AQUAE
A:
[8-216]
----
E
N
I
K
K
V
--
I
--
R
G
Y
----
E
I
--
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
---------
V
D
Y
T
N
E
K
E
L
S
-
L
L
--
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
---
M
L
K
M
G
K
P
----------
K
K
E
A
K
E
R
G
E
Y
L
L
S
--
E
L
G
L
G
D
K
L
-
S
R
K
P
Y
-
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
E
-
L
-
T
-
H
R
T
L
E
M
K
D
G
K
108
HHSearch
75.94
30%
-126
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[4-211]
-
V
Q
L
Q
N
V
T
K
A
--
W
--
G
E
V
----
V
V
--
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
---------
M
N
D
T
P
-------
P
--
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
---
L
K
L
A
G
A
K
----------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
--
V
L
Q
L
A
H
L
L
-
D
R
K
P
K
-
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
-
K
R
L
G
R
T
M
I
Y
V
T
H
D
-
Q
V
E
A
M
T
L
-
A
-
D
K
I
V
V
L
D
A
G
R
118
HHSearch
71.97
32%
-117
- C1 -
-
2YYZ
1
?
A:
[4-211]
-
I
R
V
V
N
L
K
K
Y
--
F
--
G
K
V
----
K
A
--
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
---------
V
N
D
I
P
P
---------
K
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
---
L
R
A
R
R
I
S
----------
K
D
E
V
E
K
R
V
V
E
I
A
R
--
K
L
L
I
D
N
L
L
-
D
R
K
P
T
-
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
-
Q
E
L
G
I
T
S
V
Y
V
T
H
D
-
Q
A
E
A
M
T
M
-
A
-
S
R
I
A
V
F
N
Q
G
K
46
PsiBlast_CBE
71.83
34%
-37
- C1 -
-
4YMU
1
?
A:
[1-212]
M
I
F
V
N
D
V
Y
K
N
--
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------------
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P--
V
K
V
K
K
M
N
----------
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
K
-
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
D
D
G
-
22
PsiBlast_CBE
71.74
37%
26
- C1 -
-
1L2T
3
Y796_METJA
B:
[1-222]
M
I
K
L
K
N
V
T
K
T
YK
M
--
G
E
E
----
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---------
T
N
D
L
D
D
D
E
L
T
-
K
I
--
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-------
L
L
T
A
---
L
E
N
V
E
L
P
LIFKYRGAMS
G
E
E
R
R
K
R
A
L
E
C
L
K
--
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
10
PsiBlast_PDB
71.32
35%
-49
- C1 -
-
2OUK
-
?
A:
[24-225]
M
I
D
V
H
Q
L
K
K
S
--
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-
D
F
D
E
G
E
I
I
I
D
G
I
---------
N
L
---
K
A
K
D
T
-
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
K
W
P
----------
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
-----------
20
PsiBlast_PDB
70.92
34%
-34
- C1 -
-
4YMS
-
?
J:
[1-212]
M
I
F
V
N
D
V
Y
K
N
--
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------------
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P--
V
K
V
K
K
M
N
----------
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
K
-
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
D
D
G
-
44
PsiBlast_CBE
70.78
34%
-41
- C1 -
-
4YMV
1
?
A:
[1-212]
M
I
F
V
N
D
V
Y
K
N
--
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------------
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P--
V
K
V
K
K
M
N
----------
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
K
-
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
D
D
G
-
45
PsiBlast_CBE
70.57
34%
-37
- C1 -
-
4YMU
1
?
J:
[1-212]
M
I
F
V
N
D
V
Y
K
N
--
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------------
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P--
V
K
V
K
K
M
N
----------
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
K
-
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
D
D
G
-
5
PsiBlast_PDB
70.41
37%
23
- C1 -
-
1L2T
3
Y796_METJA
A:
[1-222]
M
I
K
L
K
N
V
T
K
T
Y
K
M
--
G
E
E
----
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---------
T
N
D
L
D
D
D
E
L
T
-
K
I
--
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-------
L
L
T
A
---
L
E
N
V
E
L
P
LIFKYR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
--
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
43
PsiBlast_CBE
70.34
34%
-36
- C1 -
-
4YMV
1
?
J:
[1-212]
M
I
F
V
N
D
V
Y
K
N
--
F
--
G
S
L
----
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------------
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P--
V
K
V
K
K
M
N
----------
K
K
E
A
E
E
L
A
V
D
L
L
A
--
K
V
G
L
L
D
K
K
-
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
G
D
R
V
I
F
M
D
D
G
-
29
PsiBlast_CBE
70.12
35%
-43
- C1 -
-
2OLK
1
?
D:
[24-225]
M
I
D
V
H
Q
L
K
K
S
--
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-
D
F
D
E
G
E
I
I
I
D
G
I
---------
N
L
---
K
A
K
D
T
-
N
L
NK
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P--
M
K
V
R
K
W
P
----------
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
-----------
23
PsiBlast_CBE
70.11
36%
26
- C1 -
-
3TIF
4
Y796_METJA
B:
[1-222]
M
V
K
L
K
N
V
T
K
T
YK
M
--
G
E
E
----
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---------
T
N
D
L
D
D
D
E
L
T
-
K
I
--
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-------
L
L
T
A
---
L
E
N
V
E
L
P
LIFKYRGAMS
G
E
E
R
R
K
R
A
L
E
C
L
K
--
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
31
PsiBlast_CBE
69.71
35%
-47
- C1 -
-
2OLK
2
?
B:
[24-225]
M
I
D
V
H
Q
L
K
K
S
--
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-
D
F
D
E
G
E
I
I
I
D
G
I
---------
N
L
---
K
A
K
D
T
-
N
L
NK
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P--
M
K
V
R
K
W
P
----------
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
-----------
6
PsiBlast_PDB
68.38
36%
23
- C1 -
-
3TIF
4
Y796_METJA
A:
[1-222]
M
V
K
L
K
N
V
T
K
T
Y
K
M
--
G
E
E
----
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---------
T
N
D
L
D
D
D
E
L
T
-
K
I
--
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-------
L
L
T
A
---
L
E
N
V
E
L
P
LIFKYR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
--
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
61
PsiBlast_CBE
68.27
33%
-5
- C1 -
-
1B0U
1
HISP_SALTY
A:
[11-230]
-----
D
L
H
K
R
--
Y
--
G
G
H
----
E
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDG
Q
L
K
V
A
D
K
N
Q
L
-
R
L
--
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P--
I
Q
V
L
G
L
S
----------
K
H
D
A
R
E
R
A
L
K
Y
L
A
--
K
V
G
I
D
E
R
A
-
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
-
E
E
-
G
K
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
H
V
S
-
S
H
V
I
F
L
H
Q
G
K
7
PsiBlast_PDB
67.65
37%
33
- C1 -
-
1F3O
1
Y796_METJA
A:
[2-222]
-
I
K
L
K
N
V
T
K
T
--
Y
K
M
G
E
E
----
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
---------
T
N
D
L
D
D
D
E
L
T
-
K
I
--
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-------
L
L
T
A
---
L
E
N
V
E
L
P
L
I
F
K
YRGAMS
G
E
E
R
R
K
R
A
L
E
C
L
K
--
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
14
PsiBlast_PDB
67.39
35%
-45
- C1 -
-
3C41
2
?
J:
[3-204]
M
I
D
V
H
Q
L
K
K
S
--
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-
D
F
D
E
G
E
I
I
I
D
G
I
---------
N
L
---
K
A
K
D
T
-
N
L
NK
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P--
M
K
V
R
K
W
P
----------
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
-----------
33
PsiBlast_CBE
67.07
35%
-48
- C1 -
-
3C41
2
?
K:
[3-204]
M
I
D
V
H
Q
L
K
K
S
--
F
--
G
S
L
----
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
-
D
F
D
E
G
E
I
I
I
D
G
I
---------
N
L
---
K
A
K
D
T
-
N
L
NK
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P--
M
K
V
R
K
W
P
----------
R
E
K
A
E
A
K
A
M
E
L
L
D
--
K
V
G
L
K
D
K
A
-
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
-
M
G
F
A
R
-
E
-
V
-----------
64
PsiBlast_CBE
51.35
31%
-26
- C1 -
-
2FF7
1
A:
[23-220]
----------------------
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
----------
D
L
A
L
---
A
D
P
-
N
W
--
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
-
N
I
S
L
A
NPG
M
S
V
E
K
V
I
----------
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
-
G
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
-
K
--
G
R
T
V
I
I
I
A
H
R
-
L
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
E
K
G
K
66
PsiBlast_CBE
49.88
31%
-28
- C1 -
-
2PMK
1
A:
[19-216]
----------------------
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
----------
D
L
A
L
---
A
D
P
-
N
W
--
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
-
N
I
S
L
A
NPG
M
S
V
E
K
V
I
----------
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
-
G
E
Q
G
A
-
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
-
K
--
G
R
T
V
I
I
I
A
H
R
-
L
S
T
V
K
-
N
-
A
-
D
R
I
I
V
M
E
K
G
K