@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0103: (2017-12-15 )
MAKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESEKIQVGLKELLEELEAGQLDFDIANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDMHLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHLQHAQPISFAYHLMAYYNMFQRDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILEFLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTGRVYGHLFGLLTVMKSLPLAYNKDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIKSAKNLQDWTLEELQTYHSLITEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70....-..-..80........90........100.......110.......120.......130.......140.......150--.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAKNTKLWGGRFEG
T
V
E
D
W
V
E
R
FGASIS
F
D
Q
K
L
A
K
F
D
V
I
G
S
L
A
H
V
Q
M
LGQTGILSLEE
S
E
K
I
Q
V
G
L
K
E
L
L
E
E
L
EA-GQ-
L
D
F
DIANE
D
I
H
M
N
M
E
V
L
L
TEKIG
P
L
A
G
K
L
HTARSRNDQ
V
A
T
D
M
H
L
Y
L
K
E
Q
L
G
Y
V
L
D
K
L
A
H
L
K
G
V
L
L
D
L
A
E
N
H
V
A
T
--IMPGYTHLQHAQ
P
I
S
F
A
Y
H
L
M
A
Y
Y
N
M
F
QRD
S
E
RFEFNQKHTDLCPL
G
A
A
A
LAGTTFP
I
D
R
Q
L
S
S
D
L
L
E
F
KQPYTNSLDAVS
D
R
D
F
I
L
E
F
L
SN
A
S
I
L
M
M
H
M
S
R
F
C
E
E
M
I
N
WCS
F
E
Y
Q
F
I
T
LSD
T
F
TIGSSIMPQKKNP
D
M
A
E
L
I
RGKT
G
R
V
Y
G
H
L
F
G
L
L
T
V
M
K
SLPLAYNK
D
L
Q
E
D
K
E
G
M
F
D
T
V
E
T
I
L
N
S
L
D
V
L
A
G
M
L
S
S
L
QV
N
K
E
K
M
Q
E
S
T
E
KDFS
N
A
T
E
L
A
D
Y
L
AGKGL
P
F
R
E
A
H
E
V
V
G
R
L
V
L
D
S
I
K
SAKNLQDW
T
L
E
E
L
Q
T
Y
H
S
L
I
T
E
D
I
Y
V
Y
LQP
K
T
A
V
Q
R
RNSLGGTGF
D
Q
V
E
Y
Q
I
A
V
AKKANEAKK
41
HHSearch
74.93
50%
25
- C4 -
-
2E9F
1
ARLY_THET8
B:
[13-460]
--------------
G
P
D
A
L
A
A
R
F
N
A
S
L
A
F
D
R
A
L
W
R
E
D
L
W
Q
N
R
V
H
A
R
M
L
H
A
V
G
L
L
S
A
E
E
L
E
A
I
L
K
G
L
D
R
I
E
E
E
I
E
A
-
G
T
-
F
P
W
R
E
E
L
E
D
V
H
M
N
L
E
A
R
L
T
E
L
V
G
P
P
G
G
K
L
H
T
A
R
S
R
N
D
Q
V
A
T
D
L
R
L
Y
L
R
G
A
I
D
E
L
L
A
L
L
L
A
L
R
R
V
L
V
R
E
A
E
K
H
L
D
P
L
Y
V
L
P
G
Y
T
H
L
Q
R
A
Q
P
V
L
L
A
H
W
F
L
A
Y
Y
E
M
L
K
R
D
A
G
R
L
E
D
A
K
E
R
L
N
E
S
P
L
G
A
A
A
L
A
G
T
G
F
P
I
D
R
H
F
T
A
R
E
L
G
F
K
A
P
M
R
N
S
L
D
A
V
A
S
R
D
F
A
L
E
V
L
S
A
L
N
I
G
M
L
H
L
S
R
M
A
E
E
L
I
L
Y
S
T
E
E
F
G
F
V
E
V
P
D
A
F
A
T
G
S
S
I
M
P
Q
K
K
N
P
D
I
L
E
L
I
R
A
K
A
G
R
V
L
G
A
F
V
G
L
S
A
V
V
K
G
L
P
L
A
Y
N
K
D
L
Q
E
D
K
E
P
L
L
D
A
L
A
T
Y
R
D
S
L
R
L
L
A
A
L
L
P
G
L
K
W
R
R
E
R
M
W
R
A
A
E
G
G
Y
T
L
A
T
E
L
A
D
Y
L
A
E
K
G
L
P
F
R
E
A
H
H
V
V
G
R
L
V
R
R
L
V
E
E
G
R
A
L
K
D
L
T
L
E
E
L
Q
A
H
H
P
L
F
A
E
D
A
L
P
L
L
R
L
E
T
A
I
H
R
R
R
S
Y
G
G
T
A
P
E
A
V
R
E
R
L
E
E
A
K
K
E
V
G
---
21
PsiBlast_CBE
74.67
50%
15
- C4 -
-
2E9F
1
ARLY_THET8
D:
[13-457]
--------------
G
P
D
A
L
A
A
R
F
N
A
S
L
A
F
D
R
A
L
W
R
E
D
L
W
Q
N
R
V
H
A
R
M
L
H
A
V
G
L
L
S
A
E
E
L
E
A
I
L
K
G
L
D
R
I
E
E
E
I
E
A
-
G
T
-
F
P
W
R
E
E
L
E
D
V
H
M
N
L
E
A
R
L
T
E
L
V
G
P
P
G
G
K
L
H
T
A
R
S
R
N
D
Q
V
A
T
D
L
R
L
Y
L
R
G
A
I
D
E
L
L
A
L
L
L
A
L
R
R
V
L
V
R
E
A
E
K
H
L
D
P
LY
V
L
P
G
Y
T
H
L
Q
R
A
Q
P
V
L
L
A
H
W
F
L
A
Y
Y
E
M
L
K
R
D
A
G
R
L
E
D
A
K
E
R
L
N
E
S
P
L
G
A
A
A
L
A
G
T
G
F
P
I
D
R
H
F
T
A
R
E
L
G
F
K
A
P
M
R
N
S
L
D
A
V
A
S
R
D
F
A
L
E
V
L
S
A
L
N
I
G
M
L
H
L
S
R
M
A
E
E
L
I
L
Y
S
T
E
E
F
G
F
V
E
V
P
D
A
F
A
T
G
S
S
I
M
P
Q
K
K
N
P
D
I
L
E
L
I
R
A
K
A
G
R
V
L
G
A
F
V
G
L
S
A
V
V
K
G
L
P
L
A
Y
N
K
D
L
Q
E
D
K
E
P
L
L
D
A
L
A
T
Y
R
D
S
L
R
L
L
A
A
L
L
P
G
L
K
W
R
R
E
R
M
W
R
A
A
E
G
G
Y
T
L
A
T
E
L
A
D
Y
L
A
E
K
G
L
P
F
R
E
A
H
H
V
V
G
R
L
V
R
R
L
V
E
E
G
R
A
L
K
D
L
T
L
E
E
L
Q
A
H
H
P
L
F
A
E
D
A
L
P
L
L
R
L
E
T
A
I
H
R
R
R
S
Y
G
G
T
A
P
E
A
V
R
E
R
L
E
E
A
K
K
------
39
HHSearch
74.52
46%
2
- C4 -
-
1TJ7
2
ARLY_ECOLI
A:
[3-457]
------
L
W
G
G
R
F
T
Q
A
A
D
Q
R
F
K
Q
F
N
D
S
L
R
F
D
Y
R
L
A
E
Q
D
I
V
G
S
V
A
W
S
K
A
L
V
T
V
G
V
L
T
A
E
E
Q
A
Q
L
E
E
A
L
N
V
L
L
E
D
V
R
A
-
R
P
Q
Q
I
L
E
S
D
A
E
D
I
H
S
W
V
E
G
K
L
I
D
K
V
G
Q
L
G
K
K
L
H
T
G
R
S
R
N
D
Q
V
A
T
D
L
K
L
W
C
K
D
T
V
S
E
L
L
T
A
N
R
Q
L
Q
S
A
L
V
E
T
A
Q
N
N
Q
D
A
--
V
M
P
G
Y
T
H
L
Q
R
A
Q
P
V
T
F
A
H
W
C
L
A
Y
V
E
M
L
A
R
D
E
S
R
L
Q
D
A
L
K
R
L
D
V
S
P
L
G
C
G
A
L
A
G
T
A
Y
E
I
D
R
E
Q
L
A
G
W
L
G
F
A
S
A
T
R
N
S
L
D
S
V
S
D
R
D
H
V
L
E
L
L
S
A
A
A
I
G
M
V
H
L
S
R
F
A
E
D
L
I
F
F
N
T
G
E
A
G
F
V
E
L
S
D
R
V
T
S
G
S
S
L
M
P
Q
K
K
N
P
D
A
L
E
L
I
R
G
K
C
G
R
V
Q
G
A
L
T
G
M
M
M
T
L
K
G
L
P
L
A
Y
N
K
D
M
Q
E
D
K
E
G
L
F
D
A
L
D
T
W
L
D
C
L
H
M
A
A
L
V
L
D
G
I
Q
V
K
R
P
R
C
Q
E
A
A
Q
Q
G
Y
A
N
A
T
E
L
A
D
Y
L
V
A
K
G
V
P
F
R
E
A
H
H
I
V
G
E
A
V
V
E
A
I
R
Q
G
K
P
L
E
D
L
P
L
S
E
L
Q
K
F
S
Q
V
I
D
E
D
V
Y
P
I
L
S
L
Q
S
C
L
D
K
R
A
A
K
G
G
V
S
P
Q
Q
V
A
Q
A
I
A
F
A
Q
A
R
L
G
---
23
PsiBlast_CBE
74.00
50%
24
- C4 -
-
2E9F
1
ARLY_THET8
B:
[13-457]
--------------
G
P
D
A
L
A
A
R
F
N
A
S
L
A
F
D
R
A
L
W
R
E
D
L
W
Q
N
R
V
H
A
R
M
L
H
A
V
G
L
L
S
A
E
E
L
E
A
I
L
K
G
L
D
R
I
E
E
E
I
E
A
-
G
T
-
F
P
W
R
E
E
L
E
D
V
H
M
N
L
E
A
R
L
T
E
L
V
G
P
P
G
G
K
L
H
T
A
R
S
R
N
D
Q
V
A
T
D
L
R
L
Y
L
R
G
A
I
D
E
L
L
A
L
L
L
A
L
R
R
V
L
V
R
E
A
E
K
H
L
D
P
L
Y
V
L
P
G
Y
T
H
L
Q
R
A
Q
P
V
L
L
A
H
W
F
L
A
Y
Y
E
M
L
K
R
D
A
G
R
L
E
D
A
K
E
R
L
N
E
S
P
L
G
A
A
A
L
A
G
T
G
F
P
I
D
R
H
F
T
A
R
E
L
G
F
K
A
P
M
R
N
S
L
D
A
V
A
S
R
D
F
A
L
E
V
L
S
A
L
N
I
G
M
L
H
L
S
R
M
A
E
E
L
I
L
Y
S
T
E
E
F
G
F
V
E
V
P
D
A
F
A
T
G
S
S
I
M
P
Q
K
K
N
P
D
I
L
E
L
I
R
A
K
A
G
R
V
L
G
A
F
V
G
L
S
A
V
V
K
G
L
P
L
A
Y
N
K
D
L
Q
E
D
K
E
P
L
L
D
A
L
A
T
Y
R
D
S
L
R
L
L
A
A
L
L
P
G
L
K
W
R
R
E
R
M
W
R
A
A
E
G
G
Y
T
L
A
T
E
L
A
D
Y
L
A
E
K
G
L
P
F
R
E
A
H
H
V
V
G
R
L
V
R
R
L
V
E
E
G
R
A
L
K
D
L
T
L
E
E
L
Q
A
H
H
P
L
F
A
E
D
A
L
P
L
L
R
L
E
T
A
I
H
R
R
R
S
Y
G
G
T
A
P
E
A
V
R
E
R
L
E
E
A
K
K
------
40
HHSearch
73.96
50%
19
- C4 -
-
2E9F
1
ARLY_THET8
C:
[14-460]
---------------
P
D
A
L
A
A
R
F
N
A
S
L
A
F
D
R
A
L
W
R
E
D
L
W
Q
N
R
V
H
A
R
M
L
H
A
V
G
L
L
S
A
E
E
L
E
A
I
L
K
G
L
D
R
I
E
E
E
I
E
A
-
G
T
-
F
P
W
R
E
E
L
E
D
V
H
M
N
L
E
A
R
L
T
E
L
V
G
P
P
G
G
K
L
H
T
A
R
S
R
N
D
Q
V
A
T
D
L
R
L
Y
L
R
G
A
I
D
E
L
L
A
L
L
L
A
L
R
R
V
L
V
R
E
A
E
K
H
L
D
P
LY
V
L
P
G
Y
T
H
L
Q
R
A
Q
P
V
L
L
A
H
W
F
L
A
Y
Y
E
M
L
K
R
D
A
G
R
L
E
D
A
K
E
R
L
N
E
S
P
L
G
A
A
A
L
A
G
T
G
F
P
I
D
R
H
F
T
A
R
E
L
G
F
K
A
P
M
R
N
S
L
D
A
V
A
S
R
D
F
A
L
E
V
L
S
A
L
N
I
G
M
L
H
L
S
R
M
A
E
E
L
I
L
Y
S
T
E
E
F
G
F
V
E
V
P
D
A
F
A
T
G
S
S
I
M
P
Q
K
K
N
P
D
I
L
E
L
I
R
A
K
A
G
R
V
L
G
A
F
V
G
L
S
A
V
V
K
G
L
P
L
A
Y
N
K
D
L
Q
E
D
K
E
P
L
L
D
A
L
A
T
Y
R
D
S
L
R
L
L
A
A
L
L
P
G
L
K
W
R
R
E
R
M
W
R
A
A
E
G
G
Y
T
L
A
T
E
L
A
D
Y
L
A
E
K
G
L
P
F
R
E
A
H
H
V
V
G
R
L
V
R
R
L
V
E
E
G
R
A
L
K
D
L
T
L
E
E
L
Q
A
H
H
P
L
F
A
E
D
A
L
P
L
L
R
L
E
T
A
I
H
R
R
R
S
Y
G
G
T
A
P
E
A
V
R
E
R
L
E
E
A
K
K
E
V
G
---
2
PsiBlast_PDB
73.74
46%
1
- C4 -
-
1TJ7
2
ARLY_ECOLI
A:
[3-453]
------
L
W
G
G
R
F
T
Q
A
A
D
Q
R
F
K
Q
F
N
D
S
L
R
F
D
Y
R
L
A
E
Q
D
I
V
G
S
V
A
W
S
K
A
L
V
T
V
G
V
L
T
A
E
E
Q
A
Q
L
E
E
A
L
N
V
L
L
E
D
V
R
A
R
P
Q
-
Q
I
L
E
S
D
A
E
D
I
H
S
W
V
E
G
K
L
I
D
K
V
G
Q
L
G
K
K
L
H
T
G
R
S
R
N
D
Q
V
A
T
D
L
K
L
W
C
K
D
T
V
S
E
L
L
T
A
N
R
Q
L
Q
S
A
L
V
E
T
A
Q
N
N
Q
D
A
--
V
M
P
G
Y
T
H
L
Q
R
A
Q
P
V
T
F
A
H
W
C
L
A
Y
V
E
M
L
A
R
D
E
S
R
L
Q
D
A
L
K
R
L
D
V
S
P
L
G
C
G
A
L
A
G
T
A
Y
E
I
D
R
E
Q
L
A
G
W
L
G
F
A
S
A
T
R
N
S
L
D
S
V
S
D
R
D
H
V
L
E
L
L
S
A
A
A
I
G
M
V
H
L
S
R
F
A
E
D
L
I
F
F
N
T
G
E
A
G
F
V
E
L
S
D
R
V
T
S
G
S
S
L
M
P
Q
K
K
N
P
D
A
L
E
L
I
R
G
K
C
G
R
V
Q
G
A
L
T
G
M
M
M
T
L
K
G
L
P
L
A
Y
N
K
D
M
Q
E
D
K
E
G
L
F
D
A
L
D
T
W
L
D
C
L
H
M
A
A
L
V
L
D
G
I
Q
V
K
R
P
R
C
Q
E
A
A
Q
Q
G
Y
A
N
A
T
E
L
A
D
Y
L
V
A
K
G
V
P
F
R
E
A
H
H
I
V
G
E
A
V
V
E
A
I
R
Q
G
K
P
L
E
D
L
P
L
S
E
L
Q
K
F
S
Q
V
I
D
E
D
V
Y
P
I
L
S
L
Q
S
C
L
D
K
R
A
A
K
G
G
V
S
P
Q
Q
V
A
Q
A
I
A
F
A
Q
-------
24
PsiBlast_CBE
73.72
46%
-1
- C4 -
-
1TJ7
1
ARLY_ECOLI
B:
[7-453]
----------
R
F
T
Q
A
A
D
Q
R
F
K
Q
F
N
D
S
L
R
F
D
Y
R
L
A
E
Q
D
I
V
G
S
V
A
W
S
K
A
L
V
T
V
G
V
L
T
A
E
E
Q
A
Q
L
E
E
A
L
N
V
L
L
E
D
V
R
A
R
P
Q
-
Q
I
L
E
S
D
A
E
D
I
H
S
W
V
E
G
K
L
I
D
K
V
G
Q
L
G
K
K
L
H
T
G
R
S
R
N
D
Q
V
A
T
D
L
K
L
W
C
K
D
T
V
S
E
L
L
T
A
N
R
Q
L
Q
S
A
L
V
E
T
A
Q
N
N
Q
D
A
--
V
M
P
G
Y
T
H
L
Q
R
A
Q
P
V
T
F
A
H
W
C
L
A
Y
V
E
M
L
A
R
D
E
S
R
L
Q
D
A
L
K
R
L
D
V
S
P
L
G
C
G
A
L
A
G
T
A
Y
E
I
D
R
E
Q
L
A
G
W
L
G
F
A
S
A
T
R
N
S
L
D
S
V
S
D
R
D
H
V
L
E
L
L
S
A
A
A
I
G
M
V
H
L
S
R
F
A
E
D
L
I
F
F
N
T
G
E
A
G
F
V
E
L
S
D
R
V
T
S
G
S
S
L
M
P
Q
K
K
N
P
D
A
L
E
L
I
R
G
K
C
G
R
V
Q
G
A
L
T
G
M
M
M
T
L
K
G
L
P
L
A
Y
N
K
D
M
Q
E
D
K
E
G
L
F
D
A
L
D
T
W
L
D
C
L
H
M
A
A
L
V
L
D
G
I
Q
V
K
R
P
R
C
Q
E
A
A
Q
Q
G
Y
A
N
A
T
E
L
A
D
Y
L
V
A
K
G
V
P
F
R
E
A
H
H
I
V
G
E
A
V
V
E
A
I
R
Q
G
K
P
L
E
D
L
P
L
S
E
L
Q
K
F
S
Q
V
I
D
E
D
V
Y
P
I
L
S
L
Q
S
C
L
D
K
R
A
A
K
G
G
V
S
P
Q
Q
V
A
Q
A
I
A
F
A
Q
-------
1
PsiBlast_PDB
73.70
50%
14
- C4 -
-
2E9F
1
ARLY_THET8
A:
[14-457]
---------------
P
D
A
L
A
A
R
F
N
A
S
L
A
F
D
R
A
L
W
R
E
D
L
W
Q
N
R
V
H
A
R
M
L
H
A
V
G
L
L
S
A
E
E
L
E
A
I
L
K
G
L
D
R
I
E
E
E
I
E
A
-
G
T
-
F
P
W
R
E
E
L
E
D
V
H
M
N
L
E
A
R
L
T
E
L
V
G
P
P
G
G
K
L
H
T
A
R
S
R
N
D
Q
V
A
T
D
L
R
L
Y
L
R
G
A
I
D
E
L
L
A
L
L
L
A
L
R
R
V
L
V
R
E
A
E
K
H
L
D
P
L
Y
V
L
P
G
Y
T
H
L
Q
R
A
Q
P
V
L
L
A
H
W
F
L
A
Y
Y
E
M
L
K
R
D
A
G
R
L
E
D
A
K
E
R
L
N
E
S
P
L
G
A
A
A
L
A
G
T
G
F
P
I
D
R
H
F
T
A
R
E
L
G
F
K
A
P
M
R
N
S
L
D
A
V
A
S
R
D
F
A
L
E
V
L
S
A
L
N
I
G
M
L
H
L
S
R
M
A
E
E
L
I
L
Y
S
T
E
E
F
G
F
V
E
V
P
D
A
F
A
T
G
S
S
I
M
P
Q
K
K
N
P
D
I
L
E
L
I
R
A
K
A
G
R
V
L
G
A
F
V
G
L
S
A
V
V
K
G
L
P
L
A
Y
N
K
D
L
Q
E
D
K
E
P
L
L
D
A
L
A
T
Y
R
D
S
L
R
L
L
A
A
L
L
P
G
L
K
W
R
R
E
R
M
W
R
A
A
E
G
G
Y
T
L
A
T
E
L
A
D
Y
L
A
E
K
G
L
P
F
R
E
A
H
H
V
V
G
R
L
V
R
R
L
V
E
E
G
R
A
L
K
D
L
T
L
E
E
L
Q
A
H
H
P
L
F
A
E
D
A
L
P
L
L
R
L
E
T
A
I
H
R
R
R
S
Y
G
G
T
A
P
E
A
V
R
E
R
L
E
E
A
K
K
------
36
HHSearch
73.43
41%
-92
- C4 -
-
1K62
-
ARLY_HUMAN
B:
[6-462]
----
G
K
L
W
G
G
R
F
V
G
A
V
D
P
I
M
E
K
F
N
A
S
I
A
Y
D
R
H
L
W
E
V
D
V
Q
G
S
K
A
Y
S
R
G
L
E
K
A
G
L
L
T
K
A
E
M
D
Q
I
L
H
G
L
D
K
V
A
E
E
W
A
Q
-
G
T
-
F
K
L
N
S
N
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
A
T
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
R
L
W
M
R
Q
T
C
S
T
L
S
G
L
L
W
E
L
I
R
T
M
V
D
R
A
E
A
E
R
D
V
--
L
F
P
G
Y
T
H
L
Q
R
A
Q
P
I
R
W
S
H
W
I
L
S
H
A
V
A
L
T
R
D
S
E
R
L
L
E
V
R
K
R
I
N
V
L
P
L
G
S
G
A
I
A
G
N
P
L
G
V
D
R
E
L
L
R
A
E
L
N
F
G
A
I
T
L
N
S
M
D
A
T
S
E
R
D
F
V
A
E
F
L
F
W
R
S
L
C
M
T
H
L
S
R
M
A
E
D
L
I
L
Y
C
T
K
E
F
S
F
V
Q
L
S
D
A
Y
S
T
G
S
S
L
M
P
R
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
C
A
G
L
L
M
T
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
E
V
S
D
T
M
S
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
H
Q
E
N
M
G
Q
A
L
S
-
P
D
M
L
A
T
D
L
A
Y
Y
L
V
R
K
G
M
P
F
R
Q
A
H
E
A
S
G
K
A
V
F
M
A
E
T
K
G
V
A
L
N
Q
L
S
L
Q
E
L
Q
T
I
S
P
L
F
S
G
D
V
I
C
V
W
D
Y
R
H
S
V
E
Q
Y
G
A
L
G
G
T
A
R
S
S
V
D
W
Q
I
R
Q
V
R
A
L
L
Q
A
Q
-
38
HHSearch
73.21
46%
1
- C4 -
-
1TJ7
1
ARLY_ECOLI
B:
[7-457]
----------
R
F
T
Q
A
A
D
Q
R
F
K
Q
F
N
D
S
L
R
F
D
Y
R
L
A
E
Q
D
I
V
G
S
V
A
W
S
K
A
L
V
T
V
G
V
L
T
A
E
E
Q
A
Q
L
E
E
A
L
N
V
L
L
E
D
V
R
A
-
R
P
Q
Q
I
L
E
S
D
A
E
D
I
H
S
W
V
E
G
K
L
I
D
K
V
G
Q
L
G
K
K
L
H
T
G
R
S
R
N
D
Q
V
A
T
D
L
K
L
W
C
K
D
T
V
S
E
L
L
T
A
N
R
Q
L
Q
S
A
L
V
E
T
A
Q
N
N
Q
D
A
--
V
M
P
G
Y
T
H
L
Q
R
A
Q
P
V
T
F
A
H
W
C
L
A
Y
V
E
M
L
A
R
D
E
S
R
L
Q
D
A
L
K
R
L
D
V
S
P
L
G
C
G
A
L
A
G
T
A
Y
E
I
D
R
E
Q
L
A
G
W
L
G
F
A
S
A
T
R
N
S
L
D
S
V
S
D
R
D
H
V
L
E
L
L
S
A
A
A
I
G
M
V
H
L
S
R
F
A
E
D
L
I
F
F
N
T
G
E
A
G
F
V
E
L
S
D
R
V
T
S
G
S
S
L
M
P
Q
K
K
N
P
D
A
L
E
L
I
R
G
K
C
G
R
V
Q
G
A
L
T
G
M
M
M
T
L
K
G
L
P
L
A
Y
N
K
D
M
Q
E
D
K
E
G
L
F
D
A
L
D
T
W
L
D
C
L
H
M
A
A
L
V
L
D
G
I
Q
V
K
R
P
R
C
Q
E
A
A
Q
Q
G
Y
A
N
A
T
E
L
A
D
Y
L
V
A
K
G
V
P
F
R
E
A
H
H
I
V
G
E
A
V
V
E
A
I
R
Q
G
K
P
L
E
D
L
P
L
S
E
L
Q
K
F
S
Q
V
I
D
E
D
V
Y
P
I
L
S
L
Q
S
C
L
D
K
R
A
A
K
G
G
V
S
P
Q
Q
V
A
Q
A
I
A
F
A
Q
A
R
L
G
---
22
PsiBlast_CBE
73.01
50%
18
- C4 -
-
2E9F
1
ARLY_THET8
C:
[14-457]
---------------
P
D
A
L
A
A
R
F
N
A
S
L
A
F
D
R
A
L
W
R
E
D
L
W
Q
N
R
V
H
A
R
M
L
H
A
V
G
L
L
S
A
E
E
L
E
A
I
L
K
G
L
D
R
I
E
E
E
I
E
A
-
G
T
-
F
P
W
R
E
E
L
E
D
V
H
M
N
L
E
A
R
L
T
E
L
V
G
P
P
G
G
K
L
H
T
A
R
S
R
N
D
Q
V
A
T
D
L
R
L
Y
L
R
G
A
I
D
E
L
L
A
L
L
L
A
L
R
R
V
L
V
R
E
A
E
K
H
L
D
P
LY
V
L
P
G
Y
T
H
L
Q
R
A
Q
P
V
L
L
A
H
W
F
L
A
Y
Y
E
M
L
K
R
D
A
G
R
L
E
D
A
K
E
R
L
N
E
S
P
L
G
A
A
A
L
A
G
T
G
F
P
I
D
R
H
F
T
A
R
E
L
G
F
K
A
P
M
R
N
S
L
D
A
V
A
S
R
D
F
A
L
E
V
L
S
A
L
N
I
G
M
L
H
L
S
R
M
A
E
E
L
I
L
Y
S
T
E
E
F
G
F
V
E
V
P
D
A
F
A
T
G
S
S
I
M
P
Q
K
K
N
P
D
I
L
E
L
I
R
A
K
A
G
R
V
L
G
A
F
V
G
L
S
A
V
V
K
G
L
P
L
A
Y
N
K
D
L
Q
E
D
K
E
P
L
L
D
A
L
A
T
Y
R
D
S
L
R
L
L
A
A
L
L
P
G
L
K
W
R
R
E
R
M
W
R
A
A
E
G
G
Y
T
L
A
T
E
L
A
D
Y
L
A
E
K
G
L
P
F
R
E
A
H
H
V
V
G
R
L
V
R
R
L
V
E
E
G
R
A
L
K
D
L
T
L
E
E
L
Q
A
H
H
P
L
F
A
E
D
A
L
P
L
L
R
L
E
T
A
I
H
R
R
R
S
Y
G
G
T
A
P
E
A
V
R
E
R
L
E
E
A
K
K
------
6
PsiBlast_PDB
72.81
43%
-95
- C4 -
-
1TJV
-
ARLY2_ANAPL
A:
[19-454]
---------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
-----------
13
PsiBlast_PDB
72.80
42%
-92
- C4 -
-
1K62
-
ARLY_HUMAN
A:
[15-452]
-------------
G
A
V
D
P
I
M
E
K
F
N
A
S
I
A
Y
D
R
H
L
W
E
V
D
V
Q
G
S
K
A
Y
S
R
G
L
E
K
A
G
L
L
T
K
A
E
M
D
Q
I
L
H
G
L
D
K
V
A
E
E
W
A
Q
-
G
T
-
F
K
L
N
S
N
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
A
T
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
R
L
W
M
R
Q
T
C
S
T
L
S
G
L
L
W
E
L
I
R
T
M
V
D
R
A
E
A
E
R
D
V
--
L
F
P
G
Y
T
H
L
Q
R
A
Q
P
I
R
W
S
H
W
I
L
S
H
A
V
A
L
T
R
D
S
E
R
L
L
E
V
R
K
R
I
N
V
L
P
L
G
S
G
A
I
A
G
N
P
L
G
V
D
R
E
L
L
R
A
E
L
N
F
G
A
I
T
L
N
S
M
D
A
T
S
E
R
D
F
V
A
E
F
L
F
W
R
S
L
C
M
T
H
L
S
R
M
A
E
D
L
I
L
Y
C
T
K
E
F
S
F
V
Q
L
S
D
A
Y
S
T
G
S
S
L
M
P
R
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
C
A
G
L
L
M
T
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
E
V
S
D
T
M
S
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
H
Q
E
N
M
G
Q
A
L
S
P
D
M
L
-
A
T
D
L
A
Y
Y
L
V
R
K
G
M
P
F
R
Q
A
H
E
A
S
G
K
A
V
F
M
A
E
T
K
G
V
A
L
N
Q
L
S
L
Q
E
L
Q
T
I
S
P
L
F
S
G
D
V
I
C
V
W
D
Y
R
H
S
V
E
Q
Y
G
A
L
G
G
T
A
R
S
S
V
D
W
Q
I
-----------
5
PsiBlast_PDB
72.68
43%
-98
- C4 -
-
1TJU
-
ARLY2_ANAPL
A:
[19-454]
---------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
S
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
-----------
14
PsiBlast_PDB
72.15
42%
-95
- C4 -
-
1XWO
-
ARLY_ANSAN
A:
[17-452]
---------------
T
D
P
I
M
Q
M
L
S
T
S
M
S
T
E
Q
R
L
S
E
V
D
I
Q
A
S
I
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
T
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
N
T
G
R
S
R
N
E
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
V
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
R
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
D
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
V
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
S
T
D
L
A
L
Y
L
V
R
K
G
M
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
N
L
T
L
E
D
L
K
S
I
S
P
L
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
M
G
G
T
A
K
S
S
V
T
T
Q
I
-----------
7
PsiBlast_PDB
72.08
43%
-92
- C4 -
-
1TJW
2
ARLY2_ANAPL
A:
[19-454]
---------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
-----------
4
PsiBlast_PDB
71.90
43%
-96
- C4 -
-
1HY1
-
ARLY2_ANAPL
A:
[17-452]
---------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
-----------
30
PsiBlast_CBE
71.75
43%
-95
- C4 -
-
1TJW
2
ARLY2_ANAPL
B:
[20-454]
----------------
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
-----------
28
PsiBlast_CBE
71.73
43%
-96
- C4 -
-
1TJW
2
ARLY2_ANAPL
D:
[19-454]
---------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
-----------
8
PsiBlast_PDB
71.70
43%
-94
- C4 -
-
1AUW
-
ARLY2_ANAPL
A:
[17-452]
---------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
-
G
V
-
F
V
V
K
Q
S
D
E
D
I
N
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
--
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
D
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
P
E
M
L
-
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
-----------