@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0106: (2017-12-15 )
MVLHSIKRNSKFYVADPASGIRKMSSDELGEIYQGITLFMVPNSDFERGKLKGKGLLDLFGRLIFNQKGLISTVILASFVLSIIGILSSLFSKVIMDEVIPYALKNSLYMFLIVFGIVSFLQTLLSAFRQHVLLFLSRKIDIPVLMGYYDHIIHLPYSFFGSRRVGDVLTRFQDAMTIKNVFTSVSISLVMDITLSVISAVVLWTINQSLFLILVFMVIVNIILIYCFKKPYKKINHEQMEANGLLNSQLIESIRNIDTIKSQHDEEQRLNKIEEKFVHTLEIGYKEGVLQNIQSTISSMTSTMGGLLFMGVGALFIIDGKMTIGDLLVFQTLSQYFTEPIQNLVGLQLTFQEVQVAVSRLQELMEVDREDIALDYSIRDFTLCDDIEFKDVTFAYGSRPPVIKNFNLRIKQGEKIAFVGESGAGKSTLVRLLLRFINPNEGKICIGANDLSDLDYGKLRKKISYIPQTIELFTGTIIDNLKIGNPSVTYEDMVRVCRIVGIHDTIQRLQNRYGSFVEEGGQNFSGGEKQRLAIARALLSKADLYIFDEATSNLDSFSEQIIQDLIFNKIMDKTTIVVAHRLSTILRCDKICFLENGTIVEYGTHEELMAKNGKYARMVGLQSVQVNQQIQSQAVLDTEEVTYG
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100..-------.-------....110........120.......130.......140.......150.......160.......170.-.-......180.......190.......200..--......210.......220.......230.......240......---.250.......260.......270.......-280.......290......--.300.----......310....--...320.......330.......340-.......350........---360.......370-......-.-..380-........390....-..-------.--400...-......410.......420.......430.......440.......450.......460.......470.......480-..-...---..490.......500.......510.......520.......530.......540.-......550.......560.......570.......580.......590.......600.......610.-.......620.......630.......640..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
L
H
SIKRNS
K
F
Y
V
AD
P
A
S
G
I
R
KM
S
S
D
E
L
G
E
I
YQ
G
I
T
L
F
M
VPNSDFERGKLKGK
G
L
L
D
L
F
G
R
L
I
FNQK
G
L
I
S
T
V
I
L
A
S
F
V
L
S
I
I
G
I
L
S
S
L
F
S
K
V
I
M
D
E
V
I
P
Y
A
L
-------
K
-------
N
S
L
Y
M
F
-
L
I
V
F
G
I
V
S
F
L
Q
T
L
L
S
A
F
R
Q
H
V
L
L
F
L
SRKIDI
P
V
L
M
G
Y
Y
D
H
I
I
H
L
P
Y
S
F
FGSR
R
V
G
D
V
L
T
R
-
F
-
Q
-
D
A
M
T
I
K
N
V
F
T
S
V
S
I
S
L
V
M
D
I
T
L
S
V
I
S
A
-
V
V
L
--
W
TI
N
Q
S
L
F
L
I
L
V
F
M
V
I
V
N
I
I
L
I
Y
C
FK
K
P
Y
K
KI
N
H
E
Q
M
E
ANGL
L
N
S
---
Q
L
I
E
S
I
R
N
I
D
T
I
K
SQ
H
D
E
E
Q
R
L
N
K
I
E
E
K
F
V
H
-
T
L
E
I
G
Y
K
E
G
V
L
Q
N
I
Q
S
T
I
S
--
S
M
T
S
T
----
M
G
G
L
L
F
MG
V
G
A
L
F
--
I
IDGK
M
T
I
G
D
L
L
V
F
Q
T
L
S
Q
Y
F
T
E
P
I
Q
-
N
L
VG
L
Q
L
T
-
F
Q
E
V
Q
V
A
V
S
---
R
L
Q
E
L
M
E
V
D
R
E
---D
I
A
L
D
Y-S-IR
D
F
--
T
LCDDIEF
K
D
V
T
F
AY-GS-------R--P--
P
V
I-KNF
N
L
R
I
KQG
E
K
I
A
F
V
GESGA
G
K
S
T
L
V
R
L
L
L
R
FINPNE
G
K
I
C
IGANDLSDL
D
Y
G
K
L
R
K
K
I
S
YI
P
Q
T
I
E
L
F
T
G
T
I
IDNLK-IG-NPS---V
T
Y
E
D
M
V
R
V
C
R
I
VG
I
H
D
T
I
Q
R
L
Q
N
R
Y
G
S
F
V
E
EGGQNFSG
G
E
K
Q
R
L
A
I
A
R
A
L
LSKA
D
-
L
Y
I
FDEATS
N
L
D
S
F
S
E
Q
I
I
Q
D
L
I
F
N
K
IMDK
T
T
I
V
V
A
H
R
L
S
T
I
L
RCD
K
I
C
F
LENG
T
I
V
EYG
T
H
E
E
L
M
AK-N-G
K
Y
A
R
M
V
G
L
Q
S
V
Q
V
N
Q
Q
I
Q
S
Q
AVLDTEEVTYG
91
HHSearch
85.34
37%
-
- C2 -
-
4RY2
-
?
A:
[101-720]
V
V
I
Y
S
I
K
-
N
R
I
I
T
V
A
D
P
G
K
G
I
V
R
Y
S
M
D
D
F
C
S
I
W
T
G
G
L
V
L
L
E
P
G
E
A
F
Q
K
G
D
Y
T
-
Q
N
M
M
V
K
F
A
G
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
L
H
I
I
-
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
-
F
-
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
--
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
---
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
-
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
--
G
I
V
A
G
----
L
G
G
I
V
I
L
W
A
G
A
Y
N
--
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
-
N
L
I
D
L
Q
P
L
-
I
Q
T
A
V
V
A
S
N
---
R
L
G
E
I
L
E
L
A
T
E
---
K
E
L
---------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
-------
R
--
K
--
P
V
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
-
L
G
-
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
-
G
C
Y
F
K
M
W
K
Q
-----------------------
90
HHSearch
85.29
37%
-
- C2 -
-
4RY2
-
?
B:
[101-720]
V
V
I
Y
S
I
K
-
N
R
I
I
T
V
A
D
P
G
K
G
I
V
R
Y
S
M
D
D
F
C
S
I
W
T
G
G
L
V
L
L
E
P
G
E
A
F
Q
K
G
D
Y
T
-
Q
N
M
M
V
K
F
A
G
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
L
H
I
I
-
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
-
F
-
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
--
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
---
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
-
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
--
G
I
V
A
G
----
L
G
G
I
V
I
L
W
A
G
A
Y
N
--
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
-
N
L
I
D
L
Q
P
L
-
I
Q
T
A
V
V
A
S
N
---
R
L
G
E
I
L
E
L
A
T
E
---
K
E
L
---------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
-------
R
--
K
--
P
V
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
-
L
G
-
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
-
G
C
Y
F
K
M
W
K
Q
-----------------------
1
PsiBlast_PDB
84.58
37%
-
- C2 -
-
4RY2
-
?
A:
[101-717]
V
V
I
Y
S
I
K
-
N
R
I
I
T
V
A
D
P
G
K
G
I
V
R
Y
S
M
D
D
F
C
S
I
W
T
G
G
L
V
L
L
E
P
G
E
A
F
Q
K
G
D
Y
T
-
Q
N
M
M
V
K
F
A
G
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
L
H
I
I
-
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
-
F
-
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
--
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
---
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
-
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
--
G
I
V
A
G
----
L
G
G
I
V
I
L
W
A
G
A
Y
N
--
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
-
N
L
I
D
L
Q
P
L
-
I
Q
T
A
V
V
A
S
N
---
R
L
G
E
I
L
E
L
A
T
E
---
K
-
E
L
--------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
-------
R
--
K
--
P
V
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
-
L
G
-
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
-
G
C
Y
F
K
M
--------------------------
21
PsiBlast_CBE
65.67
37%
-46
- C2 -
-
4S0F
2
?
B:
[161-720]
-----------------------------------------------------------
F
A
G
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
L
H
I
I
-
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
-
F
-
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
--
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
---
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
-
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
--
G
I
V
A
G
----
L
G
G
I
V
I
L
W
A
G
A
Y
N
--
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
-
N
L
I
D
L
Q
P
L
-
I
Q
T
A
V
V
A
S
N
---
R
L
G
E
I
L
E
L
A
T
E
---
K
-
E
L
R
E
-
D
-
S
D
D
F
VI
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
-------
R
--
K
--
P
V
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
-
L
G
-
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
-
G
C
Y
F
K
M
--------------------------
2
PsiBlast_PDB
65.43
37%
-45
* C2 *
-
4S0F
2
?
A:
[161-720]
-----------------------------------------------------------
F
A
G
F
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
-------
L
-------
N
D
L
H
I
I
-
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
-
F
-
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
--
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
---
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
-
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
--
G
I
V
A
G
----
L
G
G
I
V
I
L
W
A
G
A
Y
N
--
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
-
N
L
I
D
L
Q
P
L
-
I
Q
T
A
V
V
A
S
N
---
R
L
G
E
I
L
E
L
A
T
E
---
K
-
E
L
R
E
-
D
-
S
D
D
F
VI
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
-------
R
--
K
--
P
V
L
-
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
-
L
G
-
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
-
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
-
G
C
Y
F
K
M
--------------------------
110
HHSearch
63.60
25%
-60
- C2 -
-
5MKK
-
?
A:
[15-591]
---------------------------------------------------------
A
R
I
L
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
PR
P
L
A
E
R
F
-------
H
L
L
L
W
I
-
S
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
-
V
T
S
-
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
-
G
F
M
--
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
---
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
-
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
F
P
V
V
--
G
F
L
G
D
----
F
A
V
A
S
L
V
Y
Y
G
G
G
E
--
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
-
D
L
S
D
K
F
N
L
-
F
Q
G
A
M
A
S
A
E
---
R
I
F
G
V
L
D
T
E
E
E
---
L
K
D
P
E
D
-
P
-
T
P
I
R
--
G
F
R
G
E
V
E
F
R
D
V
W
L
A
Y
-
T
P
KGVEPTE
K
--
D
--
W
V
L
-
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
-
L
F
-
D
P
S
---
V
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
-
G
-
G
Y
Y
A
A
L
--------------------------
105
HHSearch
63.25
28%
-55
- C2 -
-
3QF4
1
Y288_THEMA
B:
[25-590]
--------------------------------------------------------
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
-
V
I
N
-
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
--
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
---
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
-
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
--
N
M
V
N
N
----
L
G
F
A
L
I
S
G
F
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
-
E
L
S
N
Q
F
N
M
-
I
Q
M
A
L
A
S
A
E
---
R
I
F
E
I
L
D
L
E
E
E
---
K
D
D
P
D
--
A
-
V
E
L
R
--
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
--
K
--
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
-
Y
G
-
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
----------------------
16
PsiBlast_PDB
61.01
30%
0
- C- -
-
4F4C
-
PGP1_CAEEL
A:
[161-704]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
-
L
-
F
-
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
--
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
---
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
----
E
R
Y
S
T
-
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
--
W
--
V
H
D
G
S
L
N
F
G
D
M
L
T
--
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
---
G
I
Y
E
V
L
--
D
R
K
PVI
D
S
S
S
K
A
-
G
-
R
K
D
M
--
K
I
K
G
D
I
T
V
E
N
V
H
F
T
Y
-
P
S
-------
R
--
P
DV
P
I
L
-
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
-
L
G
-
K
E
G
---
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
-
Q
-
G
L
Y
Y
D
L
V
T
A
Q
T
---------------------
98
HHSearch
59.78
30%
-30
- C2 -
-
4A82
-
Y1866_STAAM
B:
[4-575]
----------------------------------------------------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
-------
L
TTDEKVH
H
L
T
I
A
I
-
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
-
V
I
N
-
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
-
S
I
M
--
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
---
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
-
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
--
N
T
V
T
D
----
I
G
P
I
I
V
I
G
V
G
A
Y
L
--
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
-
R
L
V
A
S
F
T
T
-
L
T
Q
S
F
A
S
M
D
---
R
V
F
Q
L
I
D
E
D
Y
D
---
I
K
N
G
V
G
-
A
-
Q
P
I
E
--
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-------
N
E-
A
--
P
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
-
L
G
-
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
-
G
A
Y
E
H
L
Y
S
I
-----------------------
104
HHSearch
59.45
28%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[25-590]
--------------------------------------------------------
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
-
V
I
N
-
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
--
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
---
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
-
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
--
N
M
V
N
N
----
L
G
F
A
L
I
S
G
F
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
-
E
L
S
N
Q
F
N
M
-
I
Q
M
A
L
A
S
A
E
---
R
I
F
E
I
L
D
L
E
E
E
---
K
D
D
P
D
--
A
-
V
E
L
R
--
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
--
K
--
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
-
Y
G
-
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
Y
E
L
F
T
S
Q
----------------------
97
HHSearch
57.29
23%
-56
- C2 -
-
5MKK
-
?
B:
[9-570]
--------------------------------------------------------
L
R
R
L
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
G
-----------------
F
G
V
Y
-
A
L
A
I
V
A
S
A
A
L
S
G
L
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
-
L
N
T
-
D
L
S
A
V
R
E
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
-
L
S
M
--
Y
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
---
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
-
Y
V
E
K
S
L
A
L
A
R
V
E
G
P
L
H
A
L
L
--
G
F
L
M
G
----
F
A
F
L
T
V
L
W
A
G
G
A
M
--
V
V
R
G
E
L
S
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
-
G
L
G
W
V
M
A
L
-
Y
Q
R
G
L
T
S
L
R
---
R
L
F
E
L
L
D
E
K
P
A
---
I
R
D
E
D
P
L
P
-
L
A
L
E
--
D
L
S
G
E
V
R
F
E
G
V
G
L
K
R
-
D
G
----------
R
--
W
L
L
-
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
-
F
G
-
L
D
E
---
V
D
R
E
R
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
V
L
G
K
Q
T
T
L
L
I
S
H
R
T
A
A
L
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
A
-
G
-
G
L
Y
A
E
M
D
R
------------------------
99
HHSearch
57.08
25%
-
- C2 -
-
3B5X
-
MSBA_VIBCH
A:
[14-576]
---------------------------------------------------------
K
R
L
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
-------
S
-------
N
F
L
R
I
L
-
P
F
M
I
L
G
L
M
F
V
R
G
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
-
I
T
Y
-
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
-
T
L
M
--
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
---
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
-
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
--
Q
M
I
A
S
----
L
A
L
F
A
V
L
F
L
A
S
V
D
--
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
-
A
L
T
S
V
T
S
E
-
F
Q
R
G
M
A
A
C
Q
---
T
L
F
G
L
M
D
L
E
T
E
---
R
D
N
G
K
----
Y
E
A
E
--
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
-
Q
G
-------
K
E-
K
--
P
A
L
-
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
-
Y
A
-
A
E
G
E--
Y
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
-
D
-
G
A
Y
A
Q
L
H
-------------------------
94
HHSearch
56.94
25%
-27
- C2 -
-
4AYX
6
ABCBA_HUMAN
A:
[7-574]
--------------------------------------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
-------
V
DY
S
----
D
N
L
T
R
L
-
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
-
L
S
S
-
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
-
S
M
M
--
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
---
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
-
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
--
G
L
S
G
N
----
L
I
V
L
S
V
L
Y
K
G
G
L
L
--
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
-
G
L
S
S
F
Y
S
E
-
L
M
K
G
L
G
A
G
G
---
R
L
W
E
L
L
E
R
E
P
K
---
L
P
F
N
E
G
-
V
I
L
N
E
K
--
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
-------
R
PE
V
--
P
I
F
-
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
-
Y
G
-
A
D
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-
P
N
G
-------------------------------
17
PsiBlast_PDB
56.26
28%
-
- C2 -
-
3B5X
-
MSBA_VIBCH
A:
[49-579]
--------------------------------------------------------------------------------------------
K
P
L
L
D
E
G
F
G
N
A
E
-------
S
-------
N
F
L
R
I
L
P
F
M
I
L
G
L
M
-
F
V
R
G
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
-
I
-
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
-
G
A
S
I
I
G
L
-
L
T
L
MF
W
N
S
W
Q
-
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
SAE
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
--
S
L
A
------
L
F
A
V
L
F
L
A
--
S
V
D
--
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
-
A
L
T
S
V
T
S
E
-
F
Q
R
G
M
A
A
C
Q
---
T
L
F
G
L
M
D
L
E
T
E
---
R
D
N
G
K
Y
-
E
-
A
E
----
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
Q
G
K
-------
E
--
K
--
P
A
L
-
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
-
E
G
E
---
Y
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
-
D
-
G
A
Y
A
Q
L
H
R
I
Q
----------------------
8
PsiBlast_PDB
56.14
29%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[48-583]
-------------------------------------------------------------------------------
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
-
N
-
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
--
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
---
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
-
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
--
N
M
V
N
N
----
L
G
F
A
L
I
S
G
F
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
-
E
L
S
N
---
Q
-
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
---
K
D
D
P
D
--
A
-
V
E
L
R
--
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
--
K
--
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
-
Y
G
-
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
-----------------------------
6
PsiBlast_PDB
55.63
29%
-38
- C2 -
-
3QF4
1
Y288_THEMA
B:
[48-583]
-------------------------------------------------------------------------------
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
-
N
-
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
--
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
---
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
-
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
--
N
M
V
N
N
----
L
G
F
A
L
I
S
G
F
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
-
E
L
S
N
---
Q
-
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
---
K
D
D
P
D
--
A
-
V
E
L
R
--
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
--
K
--
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
-
Y
G
-
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
-----------------------------
11
PsiBlast_PDB
55.60
28%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[65-579]
-------------------------------------------------------------------------------------------------------------------------
L
W
M
P
-
L
V
V
I
G
L
M
-
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
-
I
-
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
-
I
M
M
--
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
---
R
L
Q
-
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
--
Q
L
I
A
S
----
L
A
-
L
A
F
V
L
Y
A
A
S
F
PS
V
M
D
-
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
-
S
L
T
N
V
N
A
Q
-
F
Q
R
G
M
A
A
C
Q
---
T
L
F
A
I
L
D
S
E
Q
E
---
K
D
E
G
K
R
-
V
-
I
D
R
A
--
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-------
R
--
E
V-
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
-
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
-
G
V
Y
A
Q
L
H
K
M
Q
----------------------
10
PsiBlast_PDB
55.48
28%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
A:
[65-579]
-------------------------------------------------------------------------------------------------------------------------
L
W
M
P
-
L
V
V
I
G
L
M
-
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
-
I
-
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
-
I
M
M
--
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
---
R
L
Q
-
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
--
Q
L
I
A
S
----
L
A
-
L
A
F
V
L
Y
A
A
S
F
PS
V
M
D
-
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
-
S
L
T
N
V
N
A
Q
-
F
Q
R
G
M
A
A
C
Q
---
T
L
F
A
I
L
D
S
E
Q
E
---
K
D
E
G
K
R
-
V
-
I
D
R
A
--
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-------
R
--
E
V-
P
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
-
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
-
G
V
Y
A
Q
L
H
K
M
Q
----------------------
7
PsiBlast_PDB
55.35
29%
-38
- C2 -
-
4Q4A
1
Y288_THEMA
B:
[48-583]
-------------------------------------------------------------------------------
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
-
N
-
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
--
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
---
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
-
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
--
N
M
V
N
N
----
L
G
F
A
L
I
S
G
F
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
-
E
L
S
N
---
Q
-
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
---
K
D
D
P
D
--
A
-
V
E
L
R
--
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
--
K
--
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
-
Y
G
-
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
-----------------------------
9
PsiBlast_PDB
55.33
28%
-38
- C2 -
-
4Q4J
-
Y288_THEMA
B:
[48-583]
-------------------------------------------------------------------------------
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
-------
D
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
-
N
-
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
--
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
---
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
-
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
--
N
M
V
N
N
----
L
G
F
A
L
I
S
G
F
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
-
E
L
S
N
---
Q
-
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
---
K
D
D
P
D
--
A
-
V
E
L
R
--
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
-------
K
--
K
--
P
V
L
-
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
-
Y
G
-
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
-
R
-
G
F
Y
-----------------------------
41
PsiBlast_CBE
39.93
41%
-29
- C2 -
-
2FGJ
2
HLYBP_ECOLX
C:
[7-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
A
-
N
P
G
---
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
---------------------
43
PsiBlast_CBE
38.59
41%
-28
- C2 -
-
2FGJ
2
HLYBP_ECOLX
A:
[7-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
-------
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
A
-
N
P
G
---
M
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
---------------------