@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0124: (2017-12-15 )
MIYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMIDEILVEDGKAVGVRTATHQEYAAKAVIVTTGTALRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTEIQPGDEVPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGLENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGINAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMRLTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTDAVTAKEFLRRPEVSYQDVVAFIGPAAEELDDKIIELIETEIKYEGYISKAMDQVAKMKRMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEGKNRSISKTLQKSK
Atome Classification :
(20 SA)
.........10........20........30........40....----------....50.....----...60........70........80........90........100.......110.......120-.......130.......140.......150.......160.......170.....-..180.-......190........200.......210.......220.......230....-----...-----240......--.250.......260.......270.......280......------.-------------290.......300.......310.......320.......330.......340.......350..-.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......-----470.......480.......490.......500.......510.......520.......---530.-----....--..540.......550.......560.......570.......580.......590.......600.......610.......620.......630.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
Y
H
FTEEY
D
I
I
V
I
GAGHAG
V
E
A
S
L
A
A
S
RMG
C
K
V
L
L
A
T
I
N
I
E
M
L
A
----------FMPCNPSIGGS----AK
G
I
V
V
R
E
V
D
A
LG
G
E
M
A
K
T
I
D
K
T
Y
I
Q
M
K
M
LNTGK
G
P
A
V
R
A
L
R
A
QA
D
K
E
L
Y
S
K
E
M
R
K
T
VENQENL
T
L
-
R
Q
T
M
I
D
E
I
L
VEDG
K
A
V
G
V
R
TAT
H
Q
E
YA
A
K
A
V
I
V
TTGT
A
L
R
G
E
I
I
I
G
D
L
K
YSSGPN-H
S
L
A
S
I
-
N
L
A
D
N
L
K
E
-LGLEIGRFKTGTPP
R
V
K
ASSINYDVTEIQPGDEVPNHFSYTSR
D
E
-----
D
Y
V
-----
K
DQV
P
C
W
L
T
--YTNGT
S
H
E
I
I
Q
NNLHRA
P
M
F
T
G
V
VKGVGPRYCP
S
I
E
D
K
I
V
------
R
-------------
F
A
DKER
H
Q
L
F
LEPEGR
N
T
E
E
V
Y
V
QGLSTSL
P
E
D
V
Q
R
D
L
V
H
S
I
KGL
E
N
A
E
M
M
RTG
Y
A
I
E
Y
DMV
L
P
H
-
Q
L
R
A
T
L
E
TKKI
S
G
L
F
TAGQTNGTSG
Y
E
E
AAGQ
G
I
I
AGI
N
A
A
L
K
IQGK
P
E
L
I
L
KRSD
G
Y
I
G
V
M
I
D
D
L
VTKGTI
E
P
Y
R
L
L
TSRA
E
Y
R
L
I
L
R
HDNAD
M
R
L
T
E
MGREIGLVDDE
R
W
A
R
F
-----
E
I
K
K
N
Q
F
D
N
E
M
K
R
L
D
SIKLKPVKETNA
K
V
E
EMGFKPL
T
D
A
V
T
A
K
E
F
L
RRPEV
S
Y
Q
D
V
V
A
F
---IG
P
A
-----
A
E
E
L
--
D
D
K
I
I
E
L
I
E
T
E
I
K
Y
E
G
Y
I
S
K
A
M
D
Q
V
A
K
M
K
R
M
E
E
KRIPANI
D
W
D
D
I
D
S
I
A
T
E
A
R
Q
K
FKLI
N
P
E
TIGQASRISGVNPA
D
I
S
I
L
M
V
Y
L
EGKN
R
S
I
S
K
T
L
QKSK
4
PsiBlast_PDB
68.87
47%
-3
- C2 -
-
3CP8
1
MNMG_CHLTE
A:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
----
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
V
-----
A
N
------
R
N
L
V
S
C
Y
L
T
--
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
------
R
-------------
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
-
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
-----
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
S
V
R
S
A
-----
A
E
E
L
C
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
---------------
26
PsiBlast_CBE
68.83
47%
-7
- C2 -
-
3CP8
1
MNMG_CHLTE
C:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
----
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
V
-----
A
N
------
R
N
L
V
S
C
Y
L
T
--
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
------
R
-------------
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
-
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
-----
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
SLS
V
R
S
A
-----
A
E
E
L
CN
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
---------------
27
PsiBlast_CBE
68.65
47%
-4
- C2 -
-
3CP8
1
MNMG_CHLTE
B:
[22-639]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
----
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
V
-----
A
N
------
R
N
L
V
S
C
Y
L
T
--
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
------
R
-------------
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
-
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
-----
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
SLS
V
R
S
A
-----
A
E
E
L
CN
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
---------------
118
HHSearch
68.40
47%
-3
* C2 *
-
3CP8
1
MNMG_CHLTE
B:
[20-639]
------
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
----
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
-
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
V
-----
A
-
N
-----
R
N
L
V
S
C
Y
L
T
--
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
------
R
-------------
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
-
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
-----
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
E
-
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
---
S
L
S
V
RSAAE
E
L
C
N
--
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
---------------
24
PsiBlast_CBE
67.80
49%
8
- C2 -
-
2ZXH
1
MNMG_AQUAE
B:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
-----
G
S
Y
WFPKG
K
E
Q
V
N
C
W
I
T
--
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
V
------
K
-------------
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
-
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
KELER
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
---------
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
---------------------------
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
---------------
3
PsiBlast_PDB
67.23
49%
8
- C2 -
-
2ZXH
1
MNMG_AQUAE
A:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
-----
G
S
Y
WFPKG
K
E
Q
V
N
C
W
I
T
--
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
I
V
------
K
-------------
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
-
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
---------
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
---------------------------
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
---------------
22
PsiBlast_CBE
66.53
49%
5
- C2 -
-
2ZXI
1
MNMG_AQUAE
C:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
-----
G
S
Y
WFPKG
K
E
Q
V
N
C
W
I
T
--
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
V
------
K
-------------
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
-
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
-
S
V
A
V
G
--
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
---------------------------
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
---------------
23
PsiBlast_CBE
66.47
49%
5
- C2 -
-
2ZXI
1
MNMG_AQUAE
B:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
-----
G
S
Y
WFPKG
K
E
Q
V
N
C
W
I
T
--
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
I
V
------
K
-------------
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
-
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
-
S
V
A
V
G
G
D
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
---------------------------
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
---------------
21
PsiBlast_CBE
66.06
49%
4
- C2 -
-
2ZXI
1
MNMG_AQUAE
D:
[26-633]
------
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
-
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
-----
G
S
Y
WFPKG
K
E
Q
V
N
C
W
I
T
--
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
V
------
K
-------------
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
-
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
KELER
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
-
S
V
A
V
G
G
D
T
R
S
Y
S
V
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
---------------------------
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
---------------
119
HHSearch
65.49
49%
34
- C2 -
-
2ZXI
1
MNMG_AQUAE
D:
[22-635]
--
A
W
V
V
D
E
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
A
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
-
E
N
L
Y
I
K
Q
E
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
-
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
V
GSYWF
P
K
G
-----
K
E
Q
V
N
C
W
I
T
--
Y
T
T
P
K
T
H
E
I
I
R
K
N
L
H
R
--------------
Y
C
P
S
I
E
D
K
I
V
------
K
-------------
F
P
D
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
P
T
-
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
Q
Y
K
L
V
-----
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
A
V
---------
G
G
--
D
T
R
S
Y
S
V
A
T
L
M
T
-
M
N
Y
T
L
D
D
V
K
E
K
---
F
G
Y
------
E
V
P
Q
--
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-------------
25
PsiBlast_CBE
63.81
47%
-9
- C2 -
-
3CP8
1
MNMG_CHLTE
D:
[22-580]
--------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
----
A
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
-
L
Q
D
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
V
-----
A
N
------
R
N
L
V
S
C
Y
L
T
--
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
I
S
------
R
-------------
F
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
P
W
-
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
-----
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
A
-
E
I
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
SLS
V
R
S
A
-----
A
E
E
L
CN
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
--------------------------------------------------------------------------
5
PsiBlast_PDB
63.00
51%
-65
- C2 -
-
3G05
-
MNMG_ECO57
A:
[29-576]
----
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
-
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
-----
Q
H
P
-----
Q
-
Q
V
P
C
Y
I
T
--
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
M
------
R
-------------
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
-
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
-----
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
---
T
P
F
A
-----
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------------
121
HHSearch
62.86
51%
-64
- C2 -
-
3G05
-
MNMG_ECO57
A:
[28-576]
---
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
-
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
------
Q
H
-----
P
Q
Q
V
P
C
Y
I
T
--
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
P
--------------
P
S
I
E
D
K
V
M
------
R
-------------
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
-
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
-----
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
---
T
P
F
A
-----
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.43
50%
-69
- C- -
-
3CES
-
MNMG_ECOLI
A:
[3-550]
----
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
-
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
-----
Q
H
P
-----
Q
-
Q
V
P
C
Y
I
T
--
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
---------------
P
S
I
E
D
K
V
M
------
R
-------------
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
-
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
-----
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
---
T
P
F
A
-----
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------------
117
HHSearch
61.32
49%
-71
- C- -
-
3CES
-
MNMG_ECOLI
B:
[1-550]
--
M
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
-
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
------
Q
H
-----
P
Q
Q
V
P
C
Y
I
T
--
H
T
N
E
K
T
H
D
V
I
R
S
N
L
-------------------
S
I
E
D
K
V
M
------
R
-------------
F
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
-
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
-----
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
---
T
P
F
A
-----
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
------------------------------------------------------------------------------------
1
PsiBlast_PDB
60.42
50%
-68
- C2 -
-
3CP2
-
MNMG_ECOLI
A:
[23-573]
----
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
----
G
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
-
F
Q
Q
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
-----------------------
I
-
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
-----
Q
H
P
-----
Q
-
Q
V
P
C
Y
I
T
--
H
T
N
-----------------------------------------------------------
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
P
R
-
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
-----
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
S
A
E
A
A
A
E
V
N
A
H
L
T
A
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
---
T
P
F
A
-----
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
Y
I
A
---------------------------------------------------------------------------------
46
PsiBlast_CBE
33.16
47%
-172
- C3 -
-
2VOJ
1
DHA_MYCTU
A:
[167-204]
------
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
D
I
N
I
D
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
32.72
47%
-180
- C3 -
-
2VHV
1
DHA_MYCTU
B:
[167-204]
------
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
D
I
N
I
D
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
32.68
24%
10
- C2 -
-
3G5S
6
TRMFO_THET8
A:
[1-407]
-------
M
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
V
P
V
R
L
F
E
M
R
-
P
K
R
M
TPAHGTDRFA
E
I
V
C
S
N
S
L
G
G
E
GETN
A
K
G
L
L
Q
A
E
M
R
R
A
G
S
L
V
M
E
A
A
D
L
A
------------
R
V
P
A
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
P
L
L
E
V
-
V
R
E
E
V
R
E
I
------------------
P
P
G
I
T
V
L
A
T
G
P
L
T
S
E
----------------------
A
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
----------------------------
Y
L
N
C
P
M
T
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
P
H
----------
F
E
A
C
V
P
V
E
E
L
A
R
R
GYQ
T
L
L
F
G
PMKPVGLVDPR
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
V
E
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
-
P
P
V
A
P
P
E
E
S
M
L
G
G
L
V
R
Y
L
A
T
-----------
A
N
------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
G
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
32.62
47%
-181
- C3 -
-
2VHX
1
DHA_MYCTU
E:
[167-204]
------
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
D
I
N
I
D
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------