@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0137: (2017-12-16 )
MYTIIKSNIKKFSLLTIFIVAGQLLLIYAATINALVLNELIAMNLERFLKLSIYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRNRVATDISNSTYQEFHSKSSGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLFSLMIMLLVPKIFASKMREVSLNLTNQNEAFLKSSETILNGFDVLASLNLLYVLPKKIKEAGILLKMVIQRKTTVETLAGAISFFLNIFFQISLVFLTGYLAIKGIVKIGTIEAIGALTGVIFTALGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPKEVNRDFPLYEAKNICYKYGDKEILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGFLRDYSGELRFCGDDIKKTSYLNMVSNVLYVDQKAYLFEGTIRDNILLEENYTDEEILQSLEQVGLSVKDFPNNILDYYVGDDGRLLSGGQKQKITLARGLIRNKKIVLIDEGTSAIDRRTSLAIERKILDREDLTVIIVTHAPHPELKQYFTKIYQFPKDFI
Atome Classification :
(20 SA)
-------.........10........20........30........40...-.--------.------------------.-------..50.----.....---..60.......---.70....-....80........90........100.......110.......120.......130.......140....-.-..150.......160........170.......180.......190......--.200...-....210------.......220.---......230.......240.......250.---...---...260..----.....270.......280.......290.......300------........310--...-...-.320.....---..330......---.--------340.--.......350.......360.......370.......380.......390.......400.......410.......420.--.--.-.----...430...--....440..--......---.450.......460.......470.......480........490.......500....-.---..510.....----------------------..520...---....530......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------M
Y
T
I
I
K
SNIKK
F
S
L
L
T
I
F
I
VAG
Q
L
L
L
I
Y
A
A
T
I
N
A
L
V
L
N
E
L
I
A
M
N
-
L
--------
E
------------------
R
-------
F
L
K
L
S
----
I
Y
Q
M
I
---
V
W
C
G
I
I
F
L
D
W
V
---
V
KNYQ
V
E
-
V
I
Q
E
F
N
L
E
I
R
N
R
V
ATDISN
S
T
Y
Q
E
F
HSKSSG
T
Y
L
S
W
LNN
D
V
Q
TL
N
D
Q
A
F
K
Q
L
F
L
V
I
KGIS
G
T
I
F
A
V
V
T
L
NH-
Y
-
H
W
S
L
T
V
A
T
L
F
S
L
M
I
-
M
L
L
V
P
K
I
F
A
S
K
M
R
E
V
S
L
NLTNQ
N
E
A
F
L
KS
S
E
T
I
L
N
G
F
--
D
V
L
A
S
L
N
-
L
L
Y
V
L
P
K
------
K
I
K
E
A
G
I
L
L
K
M
---
V
I
QRK
T
T
V
E
T
L
A
G
A
I
S
F
F
L
N
I
F
F
Q
I
S
L
V
F
L
---
T
G
Y
---
L
A
I
K
G
I
V
K
----IG
T
I
E
A
I
G
A
L
T
G
V
I
F
T
A
L
G
E
L
G
G
Q
L
S
S
I
IGTK
P
I
F
L
K
-------
L
Y
S
INPIESNK--MND-I
E
P
-
K
EVNRDFP
L
---
Y
E
A
K
N
I
C
Y
KYG---
D
--------
K
E
-
I
--
L
K
N
L
N
F
C
F
QRNE
K
Y
L
I
L
GESGS
G
K
S
T
L
L
K
L
L
N
G
F
L
R
DYSG
E
L
R
FCGD
D
I
K
K
T
S
Y
L
N
M
V
S
N
V
L
Y
VDQ
K
A
Y
L
F
EGTIRD
N
I
L
L--E--E-N----Y
T
D
E
E
I
L
Q
S
--
L
E
Q
VG--
L
S
--
V
K
DFPN---
N
I
L
D
Y
Y
VGDDGRLLSGGQ
K
Q
K
I
T
L
A
R
G
LIRN
K
K
-
I
V
L
IDEGT
S
A
I
D
R
R
T
S
L
A
I
E
R
K
ILD-R---ED
L
T
V
I
I
V
TH----------------------AP
H
P
E
L
K
Q
---
Y
F
T
K
I
Y
QF
P
K
DFI
1
PsiBlast_PDB
73.95
23%
-
- C3 -
-
3B5W
-
MSBA_ECOLI
A:
[27-537]
------------------------
L
I
V
A
G
V
A
L
I
L
N
A
A
S
-
D
T
F
M
L
S
L
L
K
P
L
L
-
D
--------
D
------------------
G
-------
F
G
K
T
D
R
S
V
L
V
W
M
P
L
---
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
V
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
-
Y
-
S
W
Q
L
S
I
I
L
I
V
L
A
P
I
-
V
S
I
A
I
R
V
V
S
K
R
F
R
N
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
--
K
E
V
L
I
F
G
-
G
Q
E
V
E
T
K
------
R
F
D
K
V
S
N
R
M
R
L
---
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
---
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
---
P
S
V
M
D
S
L
T
----
A
G
T
I
T
-------
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
T
I
--
L
D
S
E
Q
--
E
K
D
-
E
G
K
-
R
V
I
E
R
A
T
G
D
---
V
E
F
R
N
V
T
F
T
Y
P
---
G
--------
R
D
-
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
E
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
--
A
RT
E
-
Q
----
Y
S
R
E
Q
I
E
E
A
--
A
R
M
A
----
Y
--
A
M
D
F
I
N
KMD
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
---
K
N
R
T
S
L
V
I
A
H
----------------------------------------------
139
HHSearch
71.67
21%
-25
- C2 -
-
5L22
2
?
B:
[12-544]
--------
R
S
Y
L
A
K
Y
K
K
T
L
I
I
V
G
L
F
S
L
F
I
N
I
L
F
L
L
P
S
I
Y
M
L
A
V
Y
D
I
V
V
P
S
T
-
S
--------
V
------------------
P
T
------
L
L
V
I
T
----
A
L
A
V
V
---
L
Y
F
A
L
G
L
L
Q
S
V
---
R
A
K
V
M
Q
I
-
I
S
L
K
L
D
S
E
L
N
K
E
V
F
T
S
S
F
E
Y
A
I
R
N
P
S
K
A
S
A
Q
P
I
-----
N
D
L
Y
Q
L
K
Q
F
L
T
S
P
V
L
F
A
I
F
D
L
P
W
V
P
I
Y
F
G
V
L
F
V
-
F
-
H
V
Y
Y
G
V
M
A
I
L
S
M
A
V
-
I
V
A
L
A
I
L
N
E
Y
I
T
K
K
K
L
K
E
S
N
E
L
L
V
R
S
T
N
F
L
N
R
A
L
L
N
A
--
E
V
V
E
A
L
G
-
M
R
N
N
L
Y
K
------
K
W
M
N
F
Y
S
K
H
L
S
---
A
F
E
E
A
T
D
R
N
N
F
L
S
N
L
T
R
I
F
R
I
M
A
Q
S
L
M
L
G
L
---
G
G
Y
---
L
A
I
K
H
E
I
T
----
T
G
M
I
V
A
G
S
I
L
L
G
R
I
L
G
P
I
D
T
I
V
N
G
W
R
Q
I
G
N
T
K
V
A
Y
T
R
-------
L
N
E
F
L
K
F
L
----------------
P
E
P
K
G
E
---
I
E
L
S
N
V
V
V
V
P
P
---
E
GK------
T
P
-
V
--
L
R
N
I
N
M
R
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
T
V
E
I
D
G
A
D
L
K
Q
W
D
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
I
E
L
F
E
G
T
V
A
E
N
I
A
R
--
F
--
G
-
E
----
L
D
S
E
K
I
I
E
A
--
A
K
L
S
G
--
A
H
D
-
V
I
I
K
L
P
---
D
G
Y
D
T
Y
I
G
P
G
G
I
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
N
P
R
-
I
V
I
L
D
E
P
D
S
N
L
D
E
Q
G
E
Q
A
L
Y
N
A
L
I
E
-
L
K
K
-
R
K
V
T
T
I
I
V
S
H
----------------------
R
I
R
--
L
L
N
---
L
V
D
K
I
A
I
M
Q
D
G
T
-
129
HHSearch
68.66
20%
-
- C2 -
-
3B5X
-
MSBA_VIBCH
A:
[17-555]
--------
W
T
Y
I
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
-
E
--------
S
------------------
N
F
------
L
R
I
L
P
----
F
M
I
L
G
---
L
M
F
V
R
G
L
S
G
F
A
---
S
S
Y
C
L
S
W
-
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
F
W
-
N
-
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
-
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
--
K
V
V
L
S
Y
G
-
G
Q
E
V
E
R
K
------
R
F
D
K
V
S
N
S
M
R
Q
---
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
---
A
S
V
---
D
S
I
R
A
E
L
T
----
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
-------
L
F
G
L
M
D
L
E
T
E
R
--
D
N
---
G
K
-
Y
E
A
E
R
V
N
G
E
---
V
D
V
K
D
V
T
F
T
Y
Q
---
G
KE------
K
P
-
A
--
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
--
A
--
A
-
E
GE--
Y
T
R
E
Q
I
E
Q
A
--
A
R
Q
A
H
--
A
M
E
-
F
I
E
N
M
P
---
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
-
L
Q
--
K
N
K
T
V
L
V
I
A
H
----------------------
R
L
S
--
T
I
E
---
Q
A
D
E
I
L
V
V
D
E
G
E
-
133
HHSearch
66.41
19%
-
- C2 -
-
4Q4H
-
?
A:
[5-544]
--------
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
F
--------
S
------------------
L
-------
V
L
K
T
G
----
I
L
M
L
I
---
V
A
L
I
G
A
V
G
G
I
G
---
C
T
V
F
A
S
Y
-
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
-
I
-
N
V
K
L
S
S
V
L
I
F
L
I
P
P
-
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
--
R
V
V
R
A
F
R
-
R
E
E
Y
E
N
E
------
N
F
R
K
A
N
E
S
L
R
R
---
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
---
G
G
V
---
L
V
R
N
N
Q
M
E
----
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
-------
V
L
E
V
L
N
E
K
P
A
I
--
E
E
A
-
D
N
A
-
L
A
L
P
N
V
E
G
S
---
V
S
F
E
N
V
E
F
R
Y
F
---
E
NT------
D
P
-
V
--
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
--
G
--
R
-
E
D---
A
T
D
D
E
I
V
E
A
--
A
K
I
A
Q
--
I
H
D
-
F
I
I
S
L
P
---
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
-
Y
T--
K
G
C
T
T
F
I
I
T
Q
----------------------
K
I
P
--
T
A
L
---
L
A
D
K
I
L
V
L
H
E
G
K
-
123
HHSearch
65.86
19%
-10
- C2 -
-
3B60
2
MSBA_SALTY
D:
[18-555]
---------
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
-
D
--------
R
------------------
S
V------
L
L
W
M
P
----
L
V
V
I
G
---
L
M
I
L
R
G
I
T
S
Y
I
---
S
S
Y
C
I
S
W
-
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
-
Y
-
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
-
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
--
K
E
V
L
I
F
G
-
G
Q
E
V
E
T
K
------
R
F
D
K
V
S
N
K
M
R
L
---
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
---
P
S
V
M
D
S
L
T
----
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
-------
L
F
A
I
L
D
S
E
Q
E
K
--
D
E
---
G
K
-
R
V
I
D
R
A
T
G
D
---
L
E
F
R
N
V
T
F
T
Y
P
---
G
RE------
V
P
-
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
--
A
--
R
-
T
EE--
Y
S
R
E
Q
I
E
E
A
--
A
R
M
A
Y
--
A
M
D-
F
I
N
K
M
D
---
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
-
L
Q--
K
N
R
T
S
L
V
I
A
H
----------------------
R
L
S
--
T
I
E
---
Q
A
D
E
I
V
V
V
E
D
G
I
-
138
HHSearch
65.38
20%
-24
- C2 -
-
3QF4
1
Y288_THEMA
B:
[30-566]
---------
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-
R
--------
F
D-----------------
L
-------
L
P
R
Y
M
----
L
I
L
G
T
---
I
Y
A
L
T
S
L
L
F
W
L
---
Q
G
K
I
M
L
T
-
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
-
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
--
T
V
I
K
L
F
T
-
R
E
E
K
E
M
E
------
K
F
D
R
V
N
E
S
L
R
K
---
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
---
L
A
L
K
D
I
I
T
----
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
-------
I
F
E
I
L
D
L
E
E
E
K
--
D
D
P
--
D
A
-
V
E
L
R
E
V
R
G
E
---
I
E
F
K
N
V
W
F
S
Y
D
---
K
K-------
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
--
G
--
N
-
P
G---
A
T
D
E
E
I
K
E
A
--
A
K
L
T
H
--
S
D
H
-
F
I
K
H
L
P
---
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
-
L
M
--
E
G
K
T
S
I
I
I
A
H
----------------------
R
L
N
--
T
I
K
---
N
A
D
L
I
I
V
L
R
D
G
E
-
130
HHSearch
64.72
20%
-27
- C2 -
-
4A82
-
Y1866_STAAM
B:
[7-552]
---------
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
-
A
--------
L
TTDE--------------
K
VHHL---
T
I
A
I
G
----
I
A
L
F
I
---
F
V
I
V
R
P
P
I
E
F
I
---
R
Q
Y
L
A
Q
W
-
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
-
L
-
D
V
K
L
T
L
A
A
L
F
I
F
P
F
-
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
--
S
V
V
K
S
F
A
-
I
E
D
N
E
A
K
------
N
F
D
K
K
N
T
N
F
L
T
---
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
---
G
A
Y
---
L
A
I
S
G
S
I
T
----
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
-------
V
F
Q
L
I
D
E
D
Y
D
I
--
K
N
G
-
V
G
A
-
Q
P
I
E
I
K
Q
G
R
---
I
D
I
D
H
V
S
F
Q
Y
N
---
D
NE------
A
P
-
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
--
G
--
R
-
P
T---
A
T
D
E
E
V
V
E
A
--
A
K
M
A
N
--
A
H
D-
F
I
M
N
L
P
---
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
-
L
S--
K
D
R
T
T
L
I
V
A
H
----------------------
R
L
S
--
T
I
T
---
H
A
D
K
I
V
V
I
E
N
G
H
-
9
PsiBlast_PDB
64.31
26%
-2
- C3 -
-
4F4C
-
PGP1_CAEEL
A:
[163-661]
-------------------------------------------------------------------------------------------------------------------------------
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
-
H
-
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
-
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
--
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
---
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
----
D
G
S
---
L
N
F
G
D
M
L
T
----
T
F
S
S
V
M
M
G
S
M
------
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
-------
I
Y
E
V
--
L
D
R
K
P
--
V
I
D
-
S
S
S
-
K
A
G
R
K
D
M
K
I
K
G
D
I
T
V
E
N
V
H
F
T
Y
P
SRP
D
--------
V
P
-
I
--
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
-
K
--
E
-
G
----
I
T
R
E
E
M
V
A
A
--
C
K
M
A
N
--
A
E
K
F
I
K
T
L
P
N
---
G
-
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
-
S
E
G
I
V
Q
Q
A
L
D
-
K
A
A
-
K
G
R
T
T
I
I
I
A
H
----------------------------------------------
124
HHSearch
64.07
15%
-70
* C2 *
-
5MKK
-
?
B:
[13-548]
--------
W
P
Y
V
G
R
Y
R
W
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
-
G
--------
F
---------------------------
G
V
Y
A
----
L
A
I
V
A
---
S
A
A
L
S
G
L
L
S
Y
A
---
M
R
R
L
A
V
V
-
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
A
-
V
-
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
-
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
--
R
V
V
K
G
Y
A
-
L
E
R
R
M
V
A
------
W
F
Q
D
L
N
R
L
Y
V
E
---
K
S
L
A
L
A
R
V
E
G
P
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
---
G
G
A
---
M
V
V
R
G
E
L
S
----
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
R
G
L
T
S
L
R
R
-------
L
F
E
L
L
D
E
K
P
A
I
--
R
D
E
D
P
L
P
-
L
A
L
E
D
L
S
G
E
---
V
R
F
E
G
V
G
L
K
R
D
---
G
--------
R
W
-
L
--
L
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
F
--
G
--
L
-
D
E---
V
D
R
E
R
V
E
W
A
--
A
R
L
A
G
--
I
H
E
-
E
I
L
A
F
P
---
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
-
V
L
--
G
K
Q
T
T
L
L
I
S
H
----------------------
R
T
A
--
A
L
R
---
H
A
D
W
I
I
V
L
D
G
G
R
-
13
PsiBlast_PDB
64.05
24%
-
- C3 -
-
4Q4H
-
Y288_THEMA
B:
[71-548]
-------------------------------------------------------------
R
------------------
R
-------
F
D
L
L
P
----
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
---
Q
G
K
I
M
L
T
-
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
-
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
----
E
N
Q
R
V
L
G
Q
----
L
N
G
I
I
E
E
D
I
S
G
L
T
-
V
I
K
L
F
T
R
------
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
---
S
G
F
G
G
W
L
A
L
K
D
I
I
T
----
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
-------
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
-
V
E
L
-
R
E
V
R
G
E
I
------
E
F
K
N
V
W
F
S
Y
D
---
K
--------
K
K
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G-
N
--
P
-
G
----
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
--
H
F
--
I
K
H
L
P
E
---
G
-
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
---
E
G
K
T
S
I
I
I
A
H
----------------------------------------------
131
HHSearch
63.25
18%
-25
- C2 -
-
4PL0
4
MCJD_ECOLX
B:
[18-555]
-----------
D
V
R
G
K
F
L
F
F
S
M
L
F
I
T
S
L
S
S
I
I
I
S
I
S
P
L
I
L
A
K
I
T
D
L
L
S
G
S
L
-
S
--------
N
FS
Y
E
--------------
Y
-------
L
V
L
L
A
----
C
L
Y
M
F
---
C
V
I
S
N
K
A
S
V
F
L
---
F
M
I
L
Q
S
S
-
L
R
I
N
M
Q
K
K
M
S
L
K
Y
L
R
E
L
Y
N
E
N
I
T
N
L
S
K
N
N
A
G
Y
T
T
Q
S
L
N
Q
A
S
N
D
I
Y
I
L
V
R
N
V
S
Q
N
I
L
S
P
V
I
Q
L
I
S
T
I
V
V
V
L
S
-
T
K
D
W
F
S
A
G
V
F
F
L
Y
I
L
V
-
F
V
I
F
N
T
R
L
T
G
S
L
A
S
L
R
K
H
S
M
D
I
T
L
N
S
Y
S
L
L
S
D
T
V
D
N
M
--
I
A
A
K
K
N
N
-
A
L
R
L
I
S
E
------
R
Y
E
D
A
L
T
Q
E
N
N
---
A
Q
K
K
Y
W
L
L
S
S
K
V
L
L
L
N
S
L
L
A
V
I
L
F
G
S
V
F
I
Y
---
N
I
L
---
G
V
L
N
G
V
V
S
----
I
G
H
F
I
M
I
T
S
Y
I
I
L
L
S
T
P
V
E
N
I
G
A
L
L
S
E
I
R
Q
S
M
S
S
L
A
G
-------
F
I
Q
R
H
A
E
N
K
A
T
--
S
P
S
--
I
P
-
F
L
N
M
E
R
K
L
N
---
L
S
I
R
E
L
S
F
S
Y
S
---
D
D-------
K
K
-
I
--
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
F
G
D
I
Y
L
N
D
I
S
L
R
N
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
--
A
--
N
Y
D
----
A
S
E
N
E
I
F
K
V
--
L
K
L
A
N
--
L
S
--
V
V
N
N
E
P
---
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
-
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
-
H
F
--
P
D
A
L
I
I
N
I
S
H
----------------------
R
I
N
--
L
L
E
---
C
S
D
C
V
Y
V
L
N
E
G
N
-
127
HHSearch
63.23
18%
-23
- C2 -
-
5U1D
-
TAP1_HUMAN
A:
[178-719]
---------
G
C
L
G
S
E
T
R
R
L
S
L
F
L
V
L
V
V
L
S
S
L
G
E
M
A
I
P
F
F
T
G
R
L
T
D
W
I
L
Q
D
G
-
S
--------
A
D
-----------------
T
-------
F
T
R
N
L
----
T
L
M
S
I
---
L
T
I
A
S
A
V
L
E
F
V
---
G
D
G
I
Y
N
N
-
T
M
G
H
V
H
S
H
L
Q
G
E
V
F
G
A
V
L
R
Q
E
T
E
F
F
Q
Q
N
Q
T
G
N
I
M
S
R
V
T
E
D
T
S
T
L
S
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
V
R
G
L
C
L
L
G
I
M
L
W
----
V
S
L
T
M
V
T
L
I
T
L
P
L
-
L
F
L
L
P
K
K
V
G
K
W
Y
Q
L
L
E
V
Q
V
R
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
M
--
P
T
V
R
S
F
A
-
N
E
E
G
E
A
Q
------
K
F
R
E
K
L
Q
E
I
K
T
---
L
N
Q
K
E
A
V
A
Y
A
V
N
S
W
T
T
S
I
S
G
M
L
L
K
V
G
I
L
Y
I
---
G
G
Q
---
L
V
T
S
G
A
V
S
----
S
G
N
L
V
T
F
V
L
Y
Q
M
Q
F
T
Q
A
V
E
V
L
L
S
I
Y
P
R
V
Q
K
A
V
G
S
S
E
K
-------
I
F
E
Y
L
D
R
-----------
G
L
-
L
T
P
L
H
L
E
G
L
---
V
Q
F
Q
D
V
S
F
A
Y
P
---
N
RPD-----
V
L
-
V
--
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
--
G
--
L
-
T
Q
K
--
P
T
M
E
E
I
T
A
A
--
A
V
K
S
G
--
A
H
S
-
F
I
S
G
L
P
---
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
-
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
-
S
PER
Y
S
R
S
V
L
L
I
T
Q
----------------------
H
L
S
--
L
V
E
---
Q
A
D
H
I
L
F
L
E
G
G
A
-
132
HHSearch
63.07
18%
-26
- C2 -
-
5EG1
3
MCJD_ECOLX
B:
[18-555]
-----------
D
V
R
G
K
F
L
F
F
S
M
L
F
I
T
S
L
S
S
I
I
I
S
I
S
P
L
I
L
A
K
I
T
D
L
L
S
G
S
L
-
S
--------
N
FS
Y
E
--------------
Y
-------
L
V
L
L
A
----
C
L
Y
M
F
---
C
V
I
S
N
K
A
S
V
F
L
---
F
M
I
L
Q
S
S
-
L
R
I
N
M
Q
K
K
M
S
L
K
Y
L
R
E
L
Y
N
E
N
I
T
N
L
S
K
N
N
A
G
Y
T
T
Q
S
L
N
Q
A
S
N
D
I
Y
I
L
V
R
N
V
S
Q
N
I
L
S
P
V
I
Q
L
I
S
T
I
V
V
V
L
S
-
T
K
D
W
F
S
A
G
V
F
F
L
Y
I
L
V
-
F
V
I
F
N
T
R
L
T
G
S
L
A
S
L
R
K
H
S
M
D
I
T
L
N
S
Y
S
L
L
S
D
T
V
D
N
M
--
I
A
A
K
K
N
N
-
A
L
R
L
I
S
E
------
R
Y
E
D
A
L
T
Q
E
N
N
---
A
Q
K
K
Y
W
L
L
S
S
K
V
L
L
L
N
S
L
L
A
V
I
L
F
G
S
V
F
I
Y
---
N
I
L
---
G
V
L
N
G
V
V
S
----
I
G
H
F
I
M
I
T
S
Y
I
I
L
L
S
T
P
V
E
N
I
G
A
L
L
S
E
I
R
Q
S
M
S
S
L
A
G
-------
F
I
Q
R
H
A
E
N
K
A
T
--
S
P
S
--
I
P
-
F
L
N
M
E
R
K
L
N
---
L
S
I
R
E
L
S
F
S
Y
S
---
D
D-------
K
K
-
I
--
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
F
G
D
I
Y
L
N
D
I
S
L
R
N
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
--
A
--
N
Y
D
----
A
S
E
N
E
I
F
K
V
--
L
K
L
A
N
--
L
S
--
V
V
N
N
E
P
---
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
-
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
-
H
F
--
P
D
A
L
I
I
N
I
S
H
----------------------
R
I
N
--
L
L
E
---
C
S
D
C
V
Y
V
L
N
E
G
N
-
136
HHSearch
63.06
18%
-35
- C2 -
-
5MKK
-
?
A:
[19-571]
---------
R
Y
V
W
P
Y
R
L
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
-
E
PR
P
L
A
E
R
F
H
------------------
L
-------
L
L
W
I
S
----
L
G
F
L
A
---
V
R
A
V
H
F
A
A
T
Y
G
---
E
T
Y
L
I
Q
W
-
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
-
L
-
S
P
K
L
T
L
V
V
L
L
V
A
P
V
-
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
--
E
T
I
Q
L
F
V
-
K
E
R
E
R
E
E
------
K
F
D
R
L
N
R
D
L
F
R
---
A
W
V
E
I
I
R
W
F
A
L
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
---
G
G
G
---
E
V
V
R
G
A
V
S
----
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
-------
I
F
G
V
L
D
T
E
E
E
L
--
K
D
P
-
E
D
P
-
T
P
I
R
G
F
R
G
E
---
V
E
F
R
D
V
W
L
A
Y
T
---
P
KGVEPTEK
D
W
-
V
--
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
--
F
--
D
-
P
S---
V
P
P
E
R
V
E
E
V
--
A
R
F
L
G
--
A
H
E
-
F
I
L
R
L
P
---
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
-
A
M
--
E
G
R
T
S
L
I
I
A
H
----------------------
R
L
S
--
T
I
R
---
H
V
D
R
I
L
V
F
R
K
G
R
-
144
Fugue
62.99
19%
-16
- C2 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-
R
--------
S
------------------
V
-------
L
L
W
M
P
----
L
V
V
I
G
---
L
M
I
L
R
G
I
T
S
Y
I
---
S
S
Y
C
I
S
W
-
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
-
Y
-
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
-
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
--
K
E
V
L
I
F
G
-
G
Q
E
V
E
T
K
------
R
F
D
K
V
S
N
K
M
R
L
---
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
---
A
S
F
---
P
S
V
M
D
S
L
T
----
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
-------
L
F
A
I
L
D
S
E
Q
E
K
--
D
E
G
-
K
R
V
-
I
D
R
A
T
G
D
L
E
---
F
R
N
V
T
F
T
Y
P
G
R
---
E
--------
V
P
-
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
AR
T
--
E
-
E
----
Y
S
R
E
Q
I
E
E
A
--
A
R
M
A
Y
A
M
D
F
--
I
N
K
M
D
N
---
G
-
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
-
L
Q
--
K
N
R
T
S
L
V
I
A
H
RLSTIEQAD
E
I
V
V
V
E
DGIIV
E
R
G
T
H
S
E
L
L
A
Q
HG
V
Y
A
Q
L
H
K
M
Q
F
G
--
137
HHSearch
62.79
20%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[30-566]
---------
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
-
R
--------
F
D-----------------
L
-------
L
P
R
Y
M
----
L
I
L
G
T
---
I
Y
A
L
T
S
L
L
F
W
L
---
Q
G
K
I
M
L
T
-
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
-
V
-
N
V
I
L
S
L
V
T
L
S
I
V
P
L
-
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
--
T
V
I
K
L
F
T
-
R
E
E
K
E
M
E
------
K
F
D
R
V
N
E
S
L
R
K
---
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
---
G
G
W
---
L
A
L
K
D
I
I
T
----
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
-------
I
F
E
I
L
D
L
E
E
E
K
--
D
D
P
--
D
A
-
V
E
L
R
E
V
R
G
E
---
I
E
F
K
N
V
W
F
S
Y
D
---
K
K-------
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
--
G
--
N
-
P
G---
A
T
D
E
E
I
K
E
A
--
A
K
L
T
H
--
S
D
H
-
F
I
K
H
L
P
---
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
-
L
M
--
E
G
K
T
S
I
I
I
A
H
----------------------
R
L
N
--
T
I
K
---
N
A
D
L
I
I
V
L
R
D
G
E
-
135
HHSearch
61.19
19%
-
- C2 -
-
5C73
-
PGLK_CAMJE
A:
[9-559]
----------
L
S
K
E
D
K
N
F
L
F
F
L
L
V
F
S
V
F
V
S
F
I
E
T
F
A
I
S
L
V
M
P
F
I
T
L
A
S
D
F
S
-
Y
F-------
D
RN
K
Y
L
I
S
L
K
E
YLNIPVF
E
I
-------
I
V
Y
F
G
----
V
G
L
I
V
---
F
Y
V
F
R
A
L
L
N
A
Y
---
Y
F
H
L
L
A
R
-
F
S
K
G
R
K
H
A
I
A
Y
K
V
F
S
K
F
L
N
I
N
Y
E
K
F
T
Q
K
N
Q
S
E
I
L
K
S
I
T
G
E
V
Y
N
L
S
T
M
I
S
S
-
F
L
L
L
M
S
E
I
F
V
V
L
L
L
Y
A
L
M
L
L
-
I
-
N
Y
K
I
T
L
F
L
S
I
F
M
V
L
N
A
F
I
L
V
K
I
L
S
P
I
I
K
K
A
G
L
R
R
E
E
A
M
K
N
F
F
E
I
L
N
T
N
L
N
N
F
--
K
F
I
K
L
K
T
-
K
E
D
G
V
L
S
------
L
F
K
A
Q
S
E
A
F
S
K
---
A
N
I
T
N
E
S
V
A
A
V
P
R
I
Y
---
L
E
G
I
G
F
C
V
L
V
F
I
---
V
V
F
---
L
V
L
K
N
E
S
D
I
S
G
I
L
S
T
I
S
I
F
V
L
A
L
Y
R
L
M
P
S
A
N
R
I
I
T
S
Y
H
D
L
L
Y
Y
H
S
S
L
N
I
-------
I
Y
Q
N
L
R
Q
E
E
E
N
--
L
G
------
E
G
K
L
S
F
N
Q
E
---
L
K
I
C
N
L
S
F
G
Y
E
---
G
K
-------
K
Y
-
L
--
F
K
N
L
N
L
N
I
K
K
G
E
K
I
A
F
I
G
E
S
G
C
G
K
S
T
L
V
D
L
I
I
G
L
L
K
P
K
E
G
Q
I
L
I
D
K
Q
E
L
N
A
S
N
A
K
N
Y
R
Q
K
I
G
Y
I
P
Q
N
I
Y
L
F
N
D
S
I
A
K
N
I
T
F
--
G
--
D
-
A
----
V
D
E
E
K
L
N
K
V
--
I
K
Q
A
N
--
L
E
H
-
F
I
K
N
L
P
---
Q
G
V
Q
T
K
V
G
D
G
G
S
N
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
Y
L
E
P
E
-
I
L
V
L
D
Q
A
T
S
A
L
D
T
Q
S
E
A
K
I
M
D
E
I
Y
K
-
I
S--
K
D
K
T
M
I
I
I
A
H
----------------------
R
L
S
--
T
I
T
---
Q
C
D
K
V
Y
R
L
E
H
G
K
-
142
HHSearch
60.65
17%
-21
- C2 -
-
5U1D
-
TAP2_HUMAN
B:
[144-679]
----------
L
S
R
P
D
L
P
L
L
V
A
A
F
F
F
L
V
L
A
V
L
G
E
T
L
I
P
H
Y
S
G
R
V
I
D
I
L
G
G
D
F
-
D
--------
P
H
-----------------
A
-------
F
A
S
A
I
----
F
F
M
C
L
---
F
S
F
G
S
S
L
S
A
G
C
---
R
G
G
C
F
T
Y
-
T
M
S
R
I
N
L
R
I
R
E
Q
L
F
S
S
L
L
R
Q
D
L
G
F
F
Q
E
T
K
T
G
E
L
N
S
R
L
S
S
D
T
T
L
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
L
S
-
I
-
S
P
R
L
T
L
L
S
L
L
H
M
P
F
-
T
I
A
A
E
K
V
Y
N
T
R
H
Q
E
V
L
R
E
I
Q
D
A
V
A
R
A
G
Q
V
V
R
E
A
V
G
G
L
--
Q
T
V
R
S
F
G
-
A
E
E
H
E
V
C
------
R
Y
K
E
A
L
E
Q
C
R
Q
---
L
Y
W
R
R
D
L
E
R
A
L
Y
L
L
V
R
R
V
L
H
L
G
V
Q
M
L
M
L
S
C
---
G
L
Q
---
Q
M
Q
D
G
E
L
T
----
Q
G
S
L
L
S
F
M
I
Y
Q
E
S
V
G
S
Y
V
Q
T
L
V
Y
I
Y
G
D
M
L
S
N
V
G
A
A
E
K
-------
V
F
S
Y
M
D
R
Q
P
N
L
--
P
S
P
--
G
T
-
L
A
P
T
T
L
Q
G
V
---
V
K
F
Q
D
V
S
F
A
Y
P
---
N
RPD-----
R
P
-
V
--
L
K
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
Q
V
L
L
D
E
K
P
I
S
Q
Y
E
H
C
Y
L
H
S
Q
V
V
S
V
G
Q
E
P
V
L
F
S
G
S
V
R
N
N
I
A
Y
--
G
--
L
Q
S
----
C
E
D
D
K
V
M
A
A
--
A
Q
A
A
H
--
A
D
D
-
F
I
Q
E
M
E
---
H
G
I
Y
T
D
V
G
E
K
G
S
Q
L
A
A
G
Q
K
Q
R
L
A
I
A
R
A
L
V
R
D
P
R
-
V
L
I
L
D
E
A
T
S
A
L
D
V
Q
C
E
Q
A
L
Q
D
W
N
S
R
-----
G
D
R
T
V
L
V
I
A
H
----------------------
R
L
Q
--
T
V
Q
---
R
A
H
Q
I
L
V
L
Q
E
G
K
-
126
HHSearch
60.37
17%
-24
- C2 -
-
4AYX
6
ABCBA_HUMAN
A:
[11-558]
--------
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-
T
--------
V
DY
S
D
--------------
N
-------
L
T
R
L
C
----
L
G
L
S
A
---
V
F
L
C
G
A
A
A
N
A
I
---
R
V
Y
L
M
Q
T
-
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
-
V
-
S
P
N
L
A
T
F
V
L
S
V
V
P
P
-
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
--
R
T
V
R
A
F
G
-
K
E
M
T
E
I
E
------
K
Y
A
S
K
V
D
H
V
M
Q
---
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
---
G
G
L
---
L
M
G
S
A
H
M
T
----
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
-------
L
W
E
L
L
E
R
E
P
K
L
--
P
F
N
E
G
V
I
-
L
N
E
K
S
F
Q
G
A
---
L
E
F
K
N
V
H
F
A
Y
P
---
A
RPE-----
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
--
G
--
A
-
D
DPSS
V
T
A
E
E
I
Q
R
V
--
A
E
V
A
N
--
A
V
A
-
F
I
R
N
F
P
---
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
-
L
M
--
D
G
R
T
V
L
V
I
A
H
----------------------
R
L
S
--
T
I
K
---
N
A
N
M
V
A
V
L
D
Q
G
K
-
141
HHSearch
58.68
18%
-15
- C2 -
-
4MYC
-
ATM1_YEAST
C:
[104-649]
-----------
N
N
K
V
R
I
R
V
L
I
A
L
G
L
L
I
S
A
K
I
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
I
A
W
-
D
--------
D
------------------
P
TVALPAA
I
G
L
T
I
----
L
C
Y
G
V
---
A
R
F
G
S
V
L
F
G
E
L
---
R
N
A
V
F
A
K
-
V
A
Q
N
A
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
L
D
L
G
W
H
L
S
R
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
-
G
A
S
F
A
A
I
T
F
S
T
M
L
L
-
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
--
E
A
V
K
Y
F
N
-
N
E
K
Y
L
A
D
------
K
Y
N
G
S
L
M
N
Y
R
D
---
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
---
G
C
T
---
G
V
I
G
G
N
L
T
----
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
-------
L
F
K
L
R
K
N
E
V
K
I
--
K
N
A
-
E
R
P
L
M
L
P
E
N
V
P
Y
D
---
I
T
F
E
N
V
T
F
G
Y
H
---
P
D-------
R
K
-
I
--
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
--
G
--
R
I
D
----
A
T
D
E
E
V
I
T
V
--
V
E
K
A
Q
--
L
A
P-
L
I
K
K
L
P
---
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
-
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
-
N
FTS
G
S
R
T
S
V
Y
I
A
H
----------------------
R
L
R
--
T
I
A
---
D
A
D
K
I
I
V
L
D
N
G
R
-