@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0146: (2017-12-16 )
MKKIVKYSSLAALGLVAAGVLAACSGGAKKEGEAASKKEIIVATNGSPRPFIYEENGELTGYEIEVVRAIFKDSDKYDVKFEKTEWSGVFAGLDADRYNMAVNNLSYTKERAEKYLYAAPIAQNPNVLVVKKDDSSIKSLDDIGGKSTEVVQATTSAKQLEAYNAEHTDNPTILNYTKADFQQIMVRLSDGQFDYKIFDKIGVETVIKNQGLDNLKVIELPSDQQPYVYPLLAQGQDELKSFVDKRIKELYKDGTLEKLSKQFFGDTYLPAEADIK
Atome Classification :
(20 SA)
.........10........20........30........40......--..50..-..----....60........70.....--...80..---..-....90......-..100.......110.......120..-.....130.-.-...-------------------..----140.......150.......160...------...-.170.......180-.........190.......200.......210.-.------.....--.-220---.-.-......230---------........-.240.......250.......260.......270....--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
K
I
V
K
Y
S
S
L
A
A
L
G
L
V
A
A
G
V
L
A
A
CSGGAKKEGEAASK
K
E
I
I
V
ATNGS--PR
P
F
I
Y-EE----NGELTG
Y
E
I
E
V
V
R
A
I
F
KDSDK--Y
D
V
K
F
EK---TE-WS
G
V
F
AGLDADR-
Y
N
M
A
VNN
L
S
Y
T
K
E
R
A
E
K
Y
L
Y
AAPIAQN-P
N
V
L
V
V
KKD-D-SSI-------------------
K
S
----
L
D
DIGGKS
T
E
V
V
Q
ATTS
A
K
Q
L
E
AYNA------EHT-DNP
T
I
L
N
Y
T
K
A
D
---
F
Q
Q
I
M
V
R
LSDGQFD
Y
K
I
F
D
KI
G
V
E
T
V
I
KNQG-L-D------N
L
K
V
I
--E-LP----S-D-QQP
Y
V
Y
P
-----------
L
L
AQ
G
Q
D
E
-
L
K
S
F
V
D
K
R
I
K
E
L
Y
KDG
T
L
E
K
L
S
K
Q
FFGDTYLPAEADIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.60
100%
-89
- C2 -
-
4EQ9
-
?
A:
[7-246]
------------------------------------
K
K
E
I
I
V
A
T
N
G
S
--
P
R
P
F
I
Y
-
E
E
----
N
G
E
L
T
G
Y
E
I
E
V
V
R
A
I
F
K
D
S
D
K
--
Y
D
V
K
F
E
K
---
T
E
-
W
S
G
V
F
A
G
L
D
A
D
R
-
Y
N
M
A
V
N
N
L
S
Y
T
K
E
R
A
E
K
Y
L
Y
A
A
P
I
A
Q
N
-
P
N
V
L
V
V
K
K
D
-
D
-
S
S
I
-------------------
K
S
----
L
D
D
I
G
G
K
S
T
E
V
V
Q
A
T
T
S
A
K
Q
L
E
A
Y
N
A
------
E
H
T
-
D
N
P
T
I
L
N
Y
T
K
A
D
---
F
Q
Q
I
M
V
R
L
S
D
G
Q
F
D
Y
K
I
F
D
K
I
G
V
E
T
V
I
K
N
Q
G
-
L
-
D
------
N
L
K
V
I
--
E
-
L
P
----
S
-
D
-
Q
Q
P
Y
V
Y
P
-----------
L
L
A
Q
G
Q
D
E
-
L
K
S
F
V
D
K
R
I
K
E
L
Y
K
D
G
T
L
E
K
L
S
K
Q
F
F
G
D
T
Y
L
P
A
E
A
D
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.44
56%
-89
- C2 -
-
4C0R
-
?
A:
[3-239]
-------------------------------------
K
T
V
T
L
A
T
V
G
T
--
T
N
P
F
S
Y
-
E
K
----
K
G
K
L
T
G
Y
D
I
E
V
A
K
E
V
F
K
A
S
D
K
--
Y
D
V
K
Y
Q
K
---
T
E
-
W
T
S
I
F
S
G
L
D
S
D
K
-
Y
Q
I
G
A
N
N
I
S
Y
T
K
E
R
A
N
K
Y
L
Y
S
N
P
T
A
S
N
-
P
L
V
L
V
V
P
K
D
---
S
D
I
-------------------
K
S
----
Y
N
D
I
A
G
H
S
T
Q
V
V
Q
G
N
T
T
V
P
M
L
Q
K
F
N
K
------
N
H
E
-
N
N
Q
V
K
L
N
F
T
S
E
D
---
L
A
H
Q
I
R
N
V
S
D
G
K
Y
D
F
K
I
F
E
K
I
S
A
E
T
I
I
K
E
Q
G
-
L
-
D
------
N
L
K
V
I
--
D
-
L
P
----
S
-
D
-
Q
K
P
Y
V
Y
F
-----------
I
F
A
Q
D
Q
K
D
-
L
Q
K
F
V
N
K
R
L
K
K
L
Y
E
N
G
T
L
E
K
L
S
K
K
Y
L
G
G
S
Y
L
P
D
K
K
D
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.59
26%
-88
- C2 -
-
2PVU
1
?
A:
[39-262]
----------------------------------
A
T
K
K
K
V
V
V
G
T
D
A
A
--
F
A
P
F
E
Y
-
M
Q
----
K
G
K
I
V
G
F
D
V
D
L
L
D
A
V
M
K
A
A
G
---
L
D
Y
E
L
K
N
---
I
G
-
W
D
P
L
F
A
S
L
Q
S
K
E
-
V
D
M
G
I
S
G
I
T
I
T
D
E
R
K
Q
S
Y
D
F
S
D
P
Y
F
E
A
-
T
Q
V
I
L
V
K
Q
G
---
S
P
V
-------------------
K
N
----
A
L
D
L
K
G
K
T
I
G
V
Q
N
A
T
T
G
Q
---
E
A
A
E
K
------
L
F
G
-
K
G
P
H
I
K
K
F
E
T
T
V
---
V
A
--
I
M
E
L
L
N
G
G
V
D
A
V
I
T
D
N
A
V
A
N
E
Y
V
K
N
N
P
-
N
-
K
------
K
L
Q
V
I
--
E
-
D
P
----
K
-
N
-
F
A
S
E
Y
Y
G
-----------
M
I
F
P
K
N
S
E
-
L
K
A
K
V
D
E
A
L
K
N
V
I
N
S
G
K
Y
T
E
I
Y
K
K
W
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.44
26%
-84
- C2 -
-
2Q2A
1
?
A:
[39-262]
----------------------------------
A
T
K
K
K
V
V
V
G
T
D
A
A
--
F
A
P
F
E
Y
-
M
Q
----
K
G
K
I
V
G
F
D
V
D
L
L
D
A
V
M
K
A
A
G
---
L
D
Y
E
L
K
N
---
I
G
-
W
D
P
L
F
A
S
L
Q
S
K
E
-
V
D
M
G
I
S
G
I
T
I
T
D
E
R
K
Q
S
Y
D
F
S
D
P
Y
F
E
A
-
T
Q
V
I
L
V
K
Q
G
---
S
P
V
-------------------
K
N
----
A
L
D
L
K
G
K
T
I
G
V
Q
N
A
T
T
G
Q
---
E
A
A
E
K
------
L
F
G
-
K
G
P
H
I
K
K
F
E
T
T
V
---
V
A
--
I
M
E
L
L
N
G
G
V
D
A
V
I
T
D
N
A
V
A
N
E
Y
V
K
N
N
P
-
N
-
K
------
K
L
Q
V
I
--
E
-
D
P
----
K
-
N
-
F
A
S
E
Y
Y
G
-----------
M
I
F
P
K
N
S
E
-
L
K
A
K
V
D
E
A
L
K
N
V
I
N
S
G
K
Y
T
E
I
Y
K
K
W
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.27
26%
-86
- C2 -
-
2Q2C
1
?
A:
[42-262]
-------------------------------------
K
K
V
V
V
G
T
D
A
A
--
F
A
P
F
E
Y
-
M
Q
----
K
G
K
I
V
G
F
D
V
D
L
L
D
A
V
M
K
A
A
G
---
L
D
Y
E
L
K
N
---
I
G
-
W
D
P
L
F
A
S
L
Q
S
K
E
-
V
D
M
G
I
S
G
I
T
I
T
D
E
R
K
Q
S
Y
D
F
S
D
P
Y
F
E
A
-
T
Q
V
I
L
V
K
Q
G
---
S
P
V
-------------------
K
N
----
A
L
D
L
K
G
K
T
I
G
V
Q
N
A
T
T
G
Q
---
E
A
A
E
K
------
L
F
G
-
K
G
P
H
I
K
K
F
E
T
T
V
---
V
A
--
I
M
E
L
L
N
G
G
V
D
A
V
I
T
D
N
A
V
A
N
E
Y
V
K
N
N
P
-
N
-
K
------
K
L
Q
V
I
--
E
-
D
P
----
K
-
N
-
F
A
S
E
Y
Y
G
-----------
M
I
F
P
K
N
S
E
-
L
K
A
K
V
D
E
A
L
K
N
V
I
N
S
G
K
Y
T
E
I
Y
K
K
W
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
56.66
24%
-53
- C2 -
-
3H7M
-
?
A:
[23-230]
-------------------------------------------------
P
Y
E
F
I
--
D
Q
----
N
G
K
P
A
G
Y
N
V
E
L
T
R
A
I
-
A
E
V
M
G
--
M
T
V
E
F
R
L
---
G
A
-
W
S
E
M
F
S
A
L
K
S
G
R
-
V
D
V
-
L
Q
G
I
S
W
S
E
K
R
A
R
Q
I
D
F
T
P
P
H
T
I
V
-
Y
H
A
I
F
A
R
R
D
-
S
-
P
P
A
-------------------
A
G
----
L
E
D
L
R
G
R
K
V
----
A
L
H
R
D
G
I
M
H
E
Y
L
A
------
E
R
G
Y
G
K
D
L
V
L
T
P
T
P
A
D
---
A
L
R
L
---
L
A
A
G
G
C
D
Y
A
V
V
A
M
V
P
G
M
Y
I
I
R
E
N
R
-
L
-
T
------
N
L
V
P
V
--
A
-
R
S
----
I
-
A
-
A
Q
R
Y
G
Y
------------
A
V
R
Q
G
D
A
E
-
L
L
A
R
F
S
E
G
L
A
I
L
R
K
T
G
Q
Y
E
A
I
R
A
K
W
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
54.93
21%
13
* C2 *
-
4POW
6
NOCT_AGRFC
A:
[4-255]
------------------------------------
Y
K
S
I
T
I
A
T
E
G
S
--
Y
A
P
Y
N
F
K
D
A
----
G
G
K
L
I
G
F
D
I
D
L
G
N
D
L
C
K
R
M
-
N
--
I
E
C
K
F
V
E
---
Q
A
-
W
D
G
I
I
P
S
L
T
A
G
R
-
Y
D
A
I
M
A
A
M
G
I
Q
P
A
R
E
K
V
I
A
F
S
R
P
Y
L
L
T
-
P
M
T
F
L
T
T
A
D
-
S
-
P
L
L
KTQVAIENLPLDNIT
P
E
Q
K
A
E
L
D
K
F
T
K
I
F
E
G
V
K
F
G
V
Q
A
G
T
S
H
E
A
F
M
K
Q
M
---------
M
P
-
S
--
V
Q
I
S
T
Y
D
T
----
I
D
N
V
V
M
D
L
K
A
G
R
I
D
A
S
L
A
S
V
S
F
L
K
P
L
T
D
K
P
D
-
N
-
K
------
D
L
K
M
F
--
G
-
P
R
MTGG
L
-
F
-
G
K
G
-
V
G
V
-----------
G
I
R
K
E
D
A
D
-
L
K
A
L
F
D
K
A
I
D
A
A
I
A
D
G
T
V
Q
K
L
S
Q
Q
W
F
G
Y
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.47
24%
-32
- C2 -
-
1WDN
1
GLNH_ECOLI
A:
[4-222]
--------------------------------------
K
L
V
V
A
T
D
T
A
--
F
V
P
F
E
F
-
K
Q
----
G
D
L
Y
V
G
F
D
V
D
L
W
A
A
I
A
K
E
L
-
K
--
L
D
Y
E
L
K
P
---
M
D
-
F
S
G
I
I
P
A
L
Q
T
K
N
-
V
D
L
A
L
A
G
I
T
I
T
D
E
R
K
K
A
I
D
F
S
D
G
Y
Y
K
S
-
G
L
L
V
M
V
K
A
N
-
N
-
N
D
V
-------------------
K
S
----
V
K
D
L
D
G
K
V
V
A
V
K
S
G
T
G
S
V
D
Y
A
K
A
-
N
I
------
K
T
K
-
D
L
R
Q
F
P
N
I
D
N
A
--------
Y
M
E
L
G
T
N
R
A
D
A
V
L
H
D
T
P
N
I
L
Y
F
I
K
T
A
G
-
N
-
G
------
Q
F
K
A
V
G
D
S
-
L
E
----
A
-
Q
-
Q
Y
G
I
A
F
P
--------------
K
G
S
D
E
-
L
R
D
K
V
N
G
A
L
K
T
L
R
E
N
G
T
Y
N
E
I
Y
K
K
W
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
52.88
21%
17
- C2 -
-
4P0I
1
NOCT_AGRFC
B:
[3-255]
-----------------------------------
D
Y
K
S
I
T
I
A
T
E
G
S
--
Y
A
P
Y
N
F
K
D
A
----
G
G
K
L
I
G
F
D
I
D
L
G
N
D
L
C
K
R
M
-
N
--
I
E
C
K
F
V
E
---
Q
A
-
W
D
G
I
I
P
S
L
T
A
G
R
-
Y
D
A
I
M
A
A
M
G
I
Q
P
A
R
E
K
V
I
A
F
S
R
P
Y
L
L
T
-
P
M
T
F
L
T
T
A
D
-
S
-
P
L
L
KTQVAIENLPLDNIT
P
E
Q
K
A
E
L
D
K
F
T
K
I
F
E
G
V
K
F
G
V
Q
A
G
T
S
H
E
A
F
M
K
Q
M
---------
M
P
-
S
--
V
Q
I
S
T
Y
D
T
----
I
D
N
V
V
M
D
L
K
A
G
R
I
D
A
S
L
A
S
V
S
F
L
K
P
L
T
D
K
P
D
-
N
-
K
------
D
L
K
M
F
--
G
-
P
R
M
T
G
G
L
-
F
-
G
K
G
-
V
G
V
-----------
G
I
R
K
E
D
A
D
-
L
K
A
L
F
D
K
A
I
D
A
A
I
A
D
G
T
V
Q
K
L
S
Q
Q
W
F
G
Y
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
52.46
21%
30
- C2 -
-
2YJP
4
?
A:
[50-281]
--------------------------------
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
--
K
P
P
F
G
Y
V
D
A
----
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L
G
SP
D
K
V
E
F
V
L
---
T
E
-
A
A
N
R
V
E
Y
V
R
S
G
K
-
V
D
L
I
L
A
N
F
T
Q
T
P
E
R
A
E
A
V
D
F
A
D
P
Y
M
K
V
-
A
L
G
V
V
S
P
K
N
---
K
P
I
-------------------
T
D
----
M
A
Q
L
K
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
S
---------
H
P
-
E
--
V
K
L
L
K
F
D
Q
----
N
T
E
T
F
D
A
L
K
D
G
R
G
V
A
L
A
H
D
N
A
L
L
W
A
W
A
K
E
N
P
----------
N
F
E
V
A
--
I
-
G
N
----
L
G
P
-
A
E
F
-
I
A
P
-----------
A
V
Q
K
G
N
A
D
-
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.45
24%
-34
- C2 -
-
1GGG
-
GLNH_ECOLI
A:
[5-222]
---------------------------------------
L
V
V
A
T
D
T
A
--
F
V
P
F
E
F
-
K
Q
----
G
D
L
Y
V
G
F
D
V
D
L
W
A
A
I
A
K
E
L
-
K
--
L
D
Y
E
L
K
P
---
M
D
-
F
S
G
I
I
P
A
L
Q
T
K
N
-
V
D
L
A
L
A
G
I
T
I
T
D
E
R
K
K
A
I
D
F
S
D
G
Y
Y
K
S
-
G
L
L
V
M
V
K
A
N
-
N
-
N
D
V
-------------------
K
S
----
V
K
D
L
D
G
K
V
V
A
V
K
S
G
T
G
S
V
D
Y
A
K
A
-
N
I
------
K
T
K
-
D
L
R
Q
F
P
N
I
D
N
A
--------
Y
M
E
L
G
T
N
R
A
D
A
V
L
H
D
T
P
N
I
L
Y
F
I
K
T
A
G
-
N
-
G
------
Q
F
K
A
V
G
D
S
-
L
E
----
A
-
Q
-
Q
Y
G
I
A
F
P
--------------
K
G
S
D
E
-
L
R
D
K
V
N
G
A
L
K
T
L
R
E
N
G
T
Y
N
E
I
Y
K
K
W
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
51.77
21%
31
- C2 -
-
2YJP
3
?
B:
[50-281]
--------------------------------
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
--
K
P
P
F
G
Y
V
D
A
----
N
G
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
L
G
SP
D
K
V
E
F
V
L
---
T
E
-
A
A
N
R
V
E
Y
V
R
S
G
K
-
V
D
L
I
L
A
N
F
T
Q
T
P
E
R
A
E
A
V
D
F
A
D
P
Y
M
K
V
-
A
L
G
V
V
S
P
K
N
---
K
P
I
-------------------
T
D
----
M
A
Q
L
K
D
Q
T
L
L
V
N
K
G
T
T
A
D
A
F
F
T
K
S
---------
H
P
-
E
--
V
K
L
L
K
F
D
Q
----
N
T
E
T
F
D
A
L
K
D
G
R
G
V
A
L
A
H
D
N
A
L
L
W
A
W
A
K
E
N
P
----------
N
F
E
V
A
--
I
-
G
N
----
L
G
P
-
A
E
F
-
I
A
P
-----------
A
V
Q
K
G
N
A
D
-
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
V
Y
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.74
24%
50
- C2 -
-
3HV1
-
?
A:
[43-272]
------------------------------------
E
K
K
I
K
I
G
F
D
A
T
--
F
V
P
M
G
Y
-
E
E
K---
D
G
S
Y
I
G
F
D
I
D
L
A
N
A
V
F
K
L
Y
G
---
I
D
V
E
W
Q
A
---
I
D
-
W
D
M
K
E
T
E
L
K
N
G
T
-
I
D
L
I
W
N
G
Y
S
V
T
D
E
R
K
Q
S
A
D
F
T
E
P
Y
M
V
N
-
E
Q
V
L
V
T
K
K
S
-------------------------
S
G
----
I
D
S
V
A
G
M
A
G
K
T
L
G
A
Q
A
G
S
S
G
Y
D
A
F
N
A
S
PKILK
D
V
V
-
A
N
Q
K
V
V
Q
Y
S
T
-----
F
T
Q
A
L
I
D
L
N
S
G
R
I
D
G
L
L
I
D
R
V
Y
A
N
Y
Y
L
E
K
S
G
V
L
-
D
------
Q
Y
N
V
-----
M
P
----
A
-
G
-
Y
E
G
E
S
F
A
-----------
V
G
A
R
K
V
D
K
T
L
I
K
K
I
N
Q
G
F
E
T
L
Y
K
N
G
E
F
Q
K
I
S
N
K
W
F
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
51.40
17%
47
- C2 -
-
4P0G
3
MLTF_PSEAE
A:
[7-435]
--------------------------
A
P
T
A
L
E
R
V
Q
K
E
G
V
L
R
V
I
T
R
N
S
--
P
A
T
Y
F
Q
-
D
R
----
N
G
E
T
-
G
F
E
Y
E
L
A
K
R
F
A
E
R
L
G
---
V
E
L
K
I
E
T
---
A
D
N
L
D
D
L
Y
A
Q
L
S
R
E
G
G
P
A
L
A
A
A
G
L
T
P
G
R
E
D
D
A
S
V
R
Y
S
H
T
Y
L
D
V
-
T
P
Q
I
I
Y
R
N
G
-
Q
-
Q
R
P
-------------------
T
R
----
P
E
D
L
V
G
K
R
I
M
V
L
K
G
S
S
H
A
E
Q
L
A
E
L
K
K
------
Q
Y
P
-
E
----
L
K
Y
E
E
S
D
AVE
V
V
D
L
L
R
M
V
D
V
G
D
I
D
L
T
L
V
D
--
S
N
E
L
A
M
N
Q
V
Y
-
F
-
P
------
N
V
R
V
A
--
F
-
D
F
----
G
-
E
-
A
R
G
L
A
W
A
-----------
L
P
G
G
D
D
D
S
-
L
M
N
E
V
N
A
F
L
D
Q
A
K
K
E
G
L
L
Q
R
L
K
D
R
Y
Y
G
H
V
D
V
L
G
Y
V
G
A
Y
T
F
A
Q
H
L
Q
Q
RLPRY
E
S
H
F
K
Q
S
G
K
Q
L
DTD
W
R
L
L
A
A
I
G
Y
Q
E
SLWQPGATSKTGVRGLMMLT
N
R
T
A
Q
A
M
GVSNRLD
P
K
Q
S
I
Q
G
G
S
K
Y
F
V
Q
I
R
S
E
LPESIKE
P
D
R
S
W
F
A
L
A
A
Y
N
IG
G
A
H
L
E
D
A
R
K
M
A
E
K
E
GLNPNK
W
L
D
V
K
K
M
LPRLAQKQWYAKTRYGYAR
G
G
E
T
V
H
F
V
Q
N
V
R
R
Y
Y
D
I
L
T
W
V
T
Q
P
Q
49
HHSearch
51.12
22%
28
- C2 -
-
5LOM
3
?
A:
[25-255]
-------------------------------
L
G
L
I
D
P
T
T
I
S
V
G
T
M
G
D
--
A
K
P
Y
A
F
T
T
A
----
D
G
N
F
T
G
F
D
I
E
L
F
L
N
V
A
G
R
L
-
G
--
F
K
K
E
Q
V
V
F
T
G
Q
E
-
F
S
A
L
M
P
S
V
A
N
G
R
-
F
D
V
A
A
A
A
I
G
T
T
A
K
R
K
E
T
V
D
F
S
D
G
Y
L
A
G
-
F
L
S
V
L
T
S
E
----
A
G
I
-------------------
T
D
----
A
A
G
L
K
G
K
R
L
G
V
V
Q
G
T
L
Q
E
I
Y
A
E
K
---------
N
F
A
-
G
--
T
D
L
V
K
F
P
D
----
N
N
S
A
V
S
A
L
N
N
G
T
V
D
A
H
F
L
D
F
E
A
A
K
D
Y
S
A
R
Y
P
----------
A
L
K
I
A
V
-
N
-
I
P
----
S
-
F
-
D
A
P
-
A
G
F
-----------
V
I
R
K
G
N
D
A
-
L
R
N
A
L
D
K
G
L
K
E
A
M
Q
D
G
T
W
K
K
L
H
E
K
W
F
P
G
T
P
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
50.83
20%
32
- C2 -
-
3KZG
-
?
B:
[18-245]
------------------------------------
S
L
N
L
T
I
G
T
S
K
F
--
N
P
P
F
E
V
W
S
G
N---
N
S
S
L
Y
G
F
D
I
D
L
M
Q
E
I
C
R
R
L
-
H
--
A
T
C
T
F
E
A
---
Y
I
-
F
D
D
L
F
P
A
L
K
N
R
E
-
V
D
L
V
I
A
S
M
I
I
T
D
E
R
K
K
H
F
I
F
S
L
P
Y
M
E
S
-
N
S
Q
Y
I
T
T
V
D
---
S
K
I
-------------------
S
T
----
F
D
D
L
H
G
K
K
I
G
V
R
K
G
T
P
Y
A
R
Q
V
L
S
E
---------
N
R
-
N
--
N
Q
V
I
F
Y
E
L
----
I
Q
D
M
L
L
G
L
S
N
N
Q
V
D
A
S
L
M
D
Y
E
A
A
K
Y
W
M
A
S
E
P
-
Y
-
A
YKLIGK
K
Y
K
L
I
--
G
-
K
K
----
I
-
S
I
G
E
G
-
Y
S
I
-----------
M
A
N
P
D
Q
F
V
-
L
I
K
K
I
N
K
I
L
L
E
M
E
A
D
G
T
Y
L
R
L
Y
S
E
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
50.62
21%
46
- C2 -
-
4OHN
1
?
A:
[12-248]
-------------------------------
S
K
Y
Q
S
N
K
S
I
T
I
G
F
D
S
T
--
F
V
P
M
G
F
A
Q
K
----
D
G
S
Y
A
G
F
D
I
D
L
A
T
A
V
F
E
K
Y
-
G
--
I
T
V
N
W
Q
P
---
I
D
-
W
D
L
K
E
A
E
L
T
K
G
T
-
I
D
L
I
W
N
G
Y
S
A
T
D
E
R
R
E
K
V
A
F
S
N
S
Y
M
K
N
-
E
Q
V
L
V
T
K
K
S
---
S
G
I
-------------------
T
T
----
A
K
D
M
T
G
K
T
L
G
A
Q
A
G
S
S
G
Y
A
D
F
E
A
N
P
E
ILKN--
I
V
A
---
N
K
E
A
N
Q
Y
Q
T
----
F
N
E
A
L
I
D
L
K
N
D
R
I
D
G
L
L
I
D
R
V
Y
A
N
Y
Y
L
E
A
E
G
-
V
L
N
------
D
Y
N
V
F
--
T
-
V
G
----
L
-
E
-
T
E
A
-
F
A
V
-----------
G
S
R
K
E
D
T
T
-
L
V
K
K
I
N
E
A
F
S
S
L
Y
K
D
G
K
F
Q
E
I
S
Q
K
W
F
G
E
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.23
27%
60
- C2 -
-
2IEE
-
YCKB_BACSU
A:
[20-245]
------------------------------------
K
G
K
I
V
V
A
T
S
G
T
--
L
Y
P
T
S
Y
-
H
D
TDSG
S
D
K
L
T
G
Y
E
V
E
V
V
R
E
A
A
K
R
L
G
---
L
K
V
E
F
K
E
---
M
G
-
I
D
G
M
L
T
A
V
N
S
G
Q
-
V
D
A
A
A
N
D
I
D
V
T
K
D
R
E
E
K
F
A
F
S
T
P
Y
K
Y
S
-
Y
G
T
A
I
V
R
K
D
-
D
L
S
G
I
-------------------
K
T
----
L
K
D
L
K
G
K
K
A
A
G
A
A
T
T
V
Y
M
E
V
A
R
K
Y
G
A
------
K
E
-------
V
I
Y
D
N
A
T
---
N
E
Q
Y
L
K
D
V
A
N
G
R
T
D
----------
V
I
L
N
D
Y
Y
-
L
-
Q
------
T
L
A
L
A
--
A
-
F
P
------
D
-
L
N
I
T
I
H
P
DIK
Y
M
P
N
K
Q
A
L
V
M
K
K
S
N
A
A
-
L
Q
K
K
M
N
E
A
L
K
E
M
S
K
D
G
S
L
T
K
L
S
K
Q
F
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
50.00
26%
69
- C2 -
-
2IEE
-
YCKB_BACSU
A:
[15-249]
-------------------------------
E
Q
I
K
D
K
G
K
I
V
V
A
T
S
G
T
--
L
Y
P
T
S
Y
H
D
T
DSG-
S
D
K
L
T
G
Y
E
V
E
V
V
R
E
A
A
K
R
L
-
G
--
L
K
V
E
F
K
E
---
M
G
-
I
D
G
M
L
T
A
V
N
S
G
Q
-
V
D
A
A
A
N
D
I
D
V
T
K
D
R
E
E
K
F
A
F
S
T
P
Y
K
Y
S
-
Y
G
T
A
I
V
R
K
D
D
L
-
S
G
I
-------------------
K
T
----
L
K
D
L
K
G
K
K
A
A
G
A
A
T
T
V
Y
M
E
V
A
R
K
Y
G
---------
A
---
K
E
V
I
Y
D
N
A
T
----
N
E
Q
Y
L
K
D
V
A
N
G
R
T
D
V
I
L
N
D
Y
Y
L
Q
T
L
A
L
A
A
F
P
-
D
-
L
------
N
I
T
I
H
--
P
D
I
K
----
Y
-
M
-
P
N
K
-
Q
A
L
-----------
V
M
K
K
S
N
A
A
-
L
Q
K
K
M
N
E
A
L
K
E
M
S
K
D
G
S
L
T
K
L
S
K
Q
F
F
N
K
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
49.84
28%
56
- C2 -
-
4GVO
1
?
A:
[8-238]
-------------------------------------
V
Q
T
I
T
V
G
T
G
T
QF
P
N
V
C
F
L
-
D
E
----
N
G
K
L
T
G
Y
D
V
E
L
V
K
E
I
D
K
R
L
P
G
--
Y
K
F
K
F
K
T
---
M
D
-
F
S
N
L
L
V
S
L
G
A
G
K
-
V
D
I
V
A
H
Q
M
E
K
S
K
E
R
E
K
K
F
L
F
N
D
V
A
Y
N
N
F
P
L
Q
L
T
V
L
D
S
-
N
-
N
S
I
-------------------
N
S
----
T
K
D
L
A
G
K
R
V
I
T
S
A
T
S
N
G
A
L
V
L
K
K
I
N
E
------
E
Q
G
-
N
N
F
E
I
A
-
Y
E
G
Q
G
---
S
N
D
T
A
N
Q
L
K
T
G
R
A
D
A
T
I
S
T
P
F
A
V
D
F
Q
N
K
T
S
A
-
I
-
K
------
E
K
V
V
G
--
D
-
V
L
----
S
-
N
-
A
K
--
V
Y
F
-----------
M
L
G
K
D
E
T
K
-
L
S
K
K
V
D
E
A
L
Q
S
I
I
D
D
G
T
L
K
K
L
S
E
K
W
L
G
A
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------