@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0157: (2017-12-16 )
MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGSYGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKPYLWIFFILNVFSAMVNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSALTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWSAEKRKTVNFNTEDALFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQFVGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLNIWMTITAIIGIVIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWLKHLAIAGLIFLFGFAIFFIYALAIGKAG
Atome Classification :
(20 SA)
-----------------------------------.........10........------20---........30..---......40........---50..-....-..60........70.....--...80...-.-.-...90....-.-...100.......110--------.......120-.--..-.-....-130-..-...-..--.140.......150..---.....160.......170--......--.180.---.---.-----.--...--------190.......200........-210..-.....---------220....------...230...---...---------.--240..----------...---..250...---------...-----.260.-..----------....270......--.280-----.---.------....-----...290.......--300.....-.---..---------.310-..-.------------.---..-..-320.......330------.........340.......--350-------.----.......--360.......370...----....380.--....-----....-----390---........400.....-.-------.410.......420---------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------MSQAISLN
Q
S
T
W
A
S
K
L
K
AM------GP---
G
I
L
M
A
T
AAVGG
S
---
H
I
V
SSTQAGG
S
Y
G
W
S
L
---
L
L
L
V
-
I
L
A
N
-
V
F
K
Y
P
F
F
R
FGAEYTADT
G
K
--
T
L
V
E
G
Y
AE-K-G-K
P
Y
L
W
I
F
F
I
-
L
-
N
V
F
S
A
M
V
NT
A
G
V
A
I
L
C
--------
S
A
I
I
A
S
AFP--M--IG-L-S
I
T
Q
-
W
S
--
L
I
-
L
V
A
-
I
I
--
W
A
M
L
L
FG
G
Y
K
L
L
D
G
M
V
---
K
W
I
M
S
A
L
T
I
A
T
V
L
A
V
I
I
A
--
A
VKHPE--Y
S
S
D
F
---
V
---E-----K--TP
W
--------
Q
M
A
A
L
P
F
I
V
S
L
L-GWMPA
P
I
E
-
I
S
A
I
N
-
S
L
W
S
A---------EK
R
K
T
VN------FNTE
D
A
L
F
D---FNT---------G--
Y
I
G
T
A
----------
I
L
A
---
V
F
F
V
A
L
G
A
---------
L
IQ-----YPTGQ-
A
V
----------
E
A
A
S
A
K
Y
I
S
Q
F
V
G
--
M
Y
-------
A
---
S
------
V
L
G
E
-----
W
S
R
Y
L
I
T
F
I
A
F
L
C
--
I
--
F
G
T
V
I
-
T
---
V
I---------D
G
Y
--
S
R-V------------
N
---
Q
E
-
S
L
-
R
L
L
I
SQKEDNR--------
K
S
L
N
I
W
M
T
I
T
A
I
I
G
I
V
I
I
K
--
F
F
--------
A
----
G
Q
V
S
T
M
L
--
R
F
A
M
I
G
S
F
L
T
T
P
F
F
A
L
----
L
N
Y
A
L
--V--TREN-----KN
L
P
-----
S
W
----
L
K
H
L
A
I
A
G
L
I
F
L
F
G
F
A
-
I
-------
F
F
I
Y
A
L
A
IGKAG-----------
15
Fugue
73.99
16%
-
- C4 -
-
4WGV
-
?
A:
[45-439]
----------------------------------------------------------------------
V
G
Y
M
D
P
G
---
N
W
I
T
S
M
Q
G
G
A
Q
Y
G
Y
T
L
---
L
F
V
I
-
L
I
S
S
-
L
A
A
M
L
L
Q
S
M
T
V
R
L
G
I
A
T
G
K
--
D
L
A
Q
M
T
R
H
-
F
-
L
-
S
K
P
V
A
I
I
F
W
-
I
-
I
A
E
L
A
I
I
A
T
D
I
A
E
V
I
G
--------
S
A
I
A
L
D
L
I
F
--
G
--
I
P
-
L
-
I
V
G
A
-
L
I
--
T
V
-
F
D
V
-
F
L
--
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
V
---
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
--
S
P
Q
L
T
D
--
I
L
N
G
F
---
V
---
P
-----
H
--
K
E
I
VT------
N
Q
G
I
L
Y
I
A
L
G
I
I
-
G
A
T
I
M
P
H
N
-
L
Y
L
H
S
-
S
I
V
Q
S
R
K
Y
D
R
HDNE
E
K
A
Q
A
I
K
------
Y
A
T
I
D
S
N
L
Q
---
L
S
I
---------
A
--
F
V
V
N
C
----------
L
L
-------
L
T
L
G
A
---------
A
L
F
-----
F
G
T
K
T
-
N
-----------
D
L
G
G
F
Y
D
L
Y
H
A
L
K
--
T
E
-------
P
---
V
------
L
G
A
T
-----
L
G
G
V
M
S
T
L
F
A
V
A
L
--
L
--
A
S
G
Q
N
-
S
---
T
I
---------
T
G
T
L
A
G
Q
-
I
------------
V
---
M
E
-
G
F
-
L
R
L
S
I
P
N
W
L
R
R
--------
L
I
T
R
S
L
A
V
I
P
V
I
I
C
L
I
I
F
K
--
G
N
--------
S
----
E
K
I
E
Q
L
L
--
V
F
S
Q
V
F
L
S
I
A
L
P
F
-
S
L
----
I
P
L
Q
L
--
A
--
T
S
N
K
-----
K
L
M
G
PFI
N
K
T
W
----
V
N
I
I
S
W
T
L
I
V
I
L
S
G
L
N
-
V
-------
Y
----------------------
18
Fugue
66.48
19%
-135
- C3 -
-
4MND
3
DIPPS_ARCFU
A:
[40-457]
-----------------------------------
L
M
K
A
V
I
L
A
A
G
--------
L
------
G
G
---
G
V
P
K
P
L
V
R
V
G
G
C
---
E
I
I
L
R
T
M
K
L
L
S
P
H
V
S
E
---
F
I
I
V
-
A
S
R
Y
-
A
D
D
I
D
A
F
L
K
D
K
G
F
N
---
Y
K
--
I
V
R
H
D
R
P
E
-
K
-
G
-
N
G
Y
S
L
L
V
A
K
-
N
-
H
V
E
D
R
F
I
L
T
M
G
D
H
V
Y
S
--------
Q
Q
F
I
E
K
A
V
R
--
G
--
E
G
-
V
--
I
A
D
-
R
E
--
P
R
-
F
V
D
-
I
G
--
E
A
----
T
K
I
R
V
E
D
G
R
V
---
A
K
I
G
K
D
L
R
E
F
D
C
V
D
T
G
F
F
--
V
L
D
-
D
S
--
I
F
E
H
A
---
E
---
K
-----
L
--
R
D
R
--------
E
E
I
P
L
S
E
I
V
K
L
------
A
R
L
P
-
V
T
Y
V
D
G
E
L
W
M
D
---------
V
D
T
K
E
D
V
------
R
R
A
N
R
A
L
V
S
---
A
A
V
---------
G
DG
F
I
S
R
K
----------
I
N
R
---
K
I
S
T
R
I
S
A
---------
A
I
V
-----
N
K
-----
V
----------
N
P
N
Q
M
T
L
I
S
F
L
V
G
--
A
F
-------
S
---
A
------
L
A
S
F
-----
F
S
---
I
P
L
A
G
L
L
Y
--
Q
--
F
S
S
I
L
---------------------
D
G
-
C
------------
D
---
G
E
-
I
A
-
R
A
S
L
K
M
S
K
K
G
G
--------
Y
V
D
S
I
L
D
R
F
V
D
F
L
F
L
A
I
I
A
--
L
L
--------
Y
----
P
K
T
A
T
V
A
--
M
F
A
I
F
G
S
V
M
V
S
Y
T
S
E
K
----
Y
K
A
E
F
GE
S
--
I
R
V
L
-----
N
Y
I
P
-----
G
K
----
R
D
E
R
I
F
L
I
M
I
F
C
L
L
S
A
-
I
SL
Q
W
I
F
W
M
F
L
F
V
A
A
I
S
L
T
R
V
V
V
T
L
L
A
V
L
V
S
5
HHSearch
66.22
16%
-104
- C4 -
-
5M94
-
?
A:
[5-405]
----------------------------------------------------------------------
V
G
Y
M
D
P
G
---
N
W
I
T
S
M
Q
G
G
A
Q
Y
G
Y
T
L
---
L
F
V
I
-
L
I
S
S
-
L
A
A
M
L
L
Q
S
M
T
V
R
L
G
I
A
T
G
K
--
D
L
A
Q
M
T
R
H
F
L
-
S
-
K
P
V
A
I
I
F
W
I
-
I
-
A
E
L
A
I
I
A
T
D
I
A
E
V
I
G
S
--------
A
I
A
L
D
L
I
F
G
--
I
--
P
L
------
I
-
V
G
A
-
L
I
-
T
V
F
-
D
V
F
L
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
V
---
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
--
S
--
P
Q
L
T
D
I
L
N
G
F
---
V
---
P
-----
H
--
K
E
I
VT------
N
Q
G
I
L
Y
I
A
L
G
I
I
-
G
A
T
I
M
P
H
N
-
L
-
Y
L
H
-
S
S
I
V
Q
---------
S
R
K
Y
D
R
H
DN
E
E
K
A
Q
A
I
K
Y
A
T
I
D
---
S
N
L
---------
Q
--
L
S
I
A
F
----------
V
V
N
---
C
L
L
L
T
L
G
A
---------
A
L
F
-----
F
G
T
K
T
-
N
--------------
D
L
G
G
F
Y
D
L
Y
H
--
A
L
K
T
-----
E
---
P
------
V
L
G
A
T
L
G
G
-
V
M
S
T
L
F
A
V
A
L
L
A
S
--
G
--
Q
N
S
T
I
-
T
---
G
T
---------
L
A
G
--
Q
I
-
V
------------
M
---
E
G
-
F
L
-
R
L
S
I
P
N
W
-
L
R
R
--------
L
I
T
R
S
---
L
A
V
I
P
V
I
I
C
L
I
I
F
K
G
N-------
S
----
E
K
I
E
Q
L
L
--
V
F
S
Q
V
F
L
S
I
A
L
P
F
S
L
I
----
P
L
Q
L
A
--
T
--
S
N
K
K
LMGP-
F
I
N
K
-----
T
W
----
V
N
I
I
S
W
T
L
I
V
I
L
S
G
L
N
-
V
-------
Y
L
I
I
Q
T
F
----------------
3
HHSearch
66.03
14%
-126
- C4 -
-
5M8K
-
?
A:
[29-465]
------------------------------------------
G
H
S
F
W
K
T
L
L
A
Y
S
------
G
P
---
G
A
L
V
A
V
G
Y
M
D
P
G
---
N
W
S
T
S
I
T
G
G
Q
N
F
Q
Y
L
L
---
L
S
I
I
-
V
I
S
S
-
L
L
A
M
L
L
Q
N
M
A
A
K
L
G
I
V
C
Q
L
--
D
L
A
Q
A
I
R
A
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T
-
S
-
R
R
L
G
F
I
F
W
I
-
L
-
T
E
L
A
I
M
A
T
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I
A
Q
V
I
G
A
--------
A
I
A
L
Y
L
L
F
K
--
I
--
P
I
------
F
-
L
A
--
V
V
-
I
T
V
L
D
V
F
L
L
L
L
L
N
R
I
G
F
R
K
I
E
A
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---
V
C
L
I
F
V
I
L
F
V
F
L
Y
Q
I
I
L
S
--
Q
--
P
A
W
H
Q
V
A
K
G
L
---
I
---
P
-----
S
--
W
A
S
VQTSPKIG
G
Q
T
P
L
S
A
S
L
G
I
I
-
G
A
T
I
M
P
H
N
-
L
-
F
L
H
-
S
A
I
S
Q
---------
S
R
K
I
D
R
T
D
S
S
K
V
A
E
A
V
R
F
S
N
W
D
---
S
N
I
---------
Q
--
L
S
L
A
M
----------
V
V
N
---
A
L
L
L
I
M
G
V
---------
A
V
F
-----
K
S
G
A
V
-
Q
D
-----------
P
----
S
F
F
G
L
Y
Q
--
A
L
S
NPDMVS
N
---
P
------
V
L
A
E
A
A
R
S
G
V
L
S
T
L
F
A
V
A
L
L
A
S
--
G
--
Q
N
S
T
I
-
T
---
G
T
---------
I
T
---
G
Q
-
V
------------
I
---
M
E
-
G
F
-
I
H
L
R
L
P
L
W
L
R
R
--------
L
V
T
R
L
I
---
A
I
I
P
V
V
V
C
V
A
--
I
T
S
H
Q
GSLD
E
H
----
Q
A
L
N
N
L
M
--
N
N
S
Q
V
F
L
A
L
A
L
P
F
S
I
V
----
P
L
L
M
L
--
T
--
D
S
A
A
QMGNQ
F
K
N
T
-----
R
W
----
V
K
V
M
G
W
L
T
V
I
I
L
T
L
L
N
-
L
-------
I
S
I
S
S
Q
I
----------------
2
HHSearch
64.73
14%
-125
- C4 -
-
5M87
1
?
A:
[29-465]
------------------------------------------
G
H
S
F
W
K
T
L
L
A
Y
S
------
G
P
---
G
A
L
V
A
V
G
Y
M
D
P
G
---
N
W
S
T
S
I
T
G
G
Q
N
F
Q
Y
L
L
---
L
S
I
I
-
V
I
S
S
-
L
L
A
M
L
L
Q
N
M
A
A
K
L
G
I
V
C
Q
L
--
D
L
A
Q
A
I
R
A
R
T
-
S
-
R
R
L
G
F
I
F
W
I
-
L
-
T
E
L
A
I
M
A
T
D
I
A
E
V
I
G
A
--------
A
I
A
L
Y
L
L
F
K
--
I
--
P
I
------
F
-
L
A
--
V
V
-
I
T
V
L
D
V
F
L
L
L
L
L
N
R
I
G
F
R
K
I
E
A
L
V
---
V
C
L
I
F
V
I
L
F
V
F
L
Y
Q
I
I
L
S
--
Q
--
P
A
W
H
Q
V
A
K
G
L
---
I
---
P
-----
S
--
W
A
S
VQTSPKIG
G
Q
T
P
L
S
A
S
L
G
I
I
-
G
A
T
I
M
P
H
N
-
L
-
F
L
H
-
S
A
I
S
Q
---------
S
R
K
I
D
R
T
D
S
S
K
V
A
E
A
V
R
F
S
N
W
D
---
S
N
I
---------
Q
--
L
S
L
A
M
----------
V
V
N
---
A
L
L
L
I
M
G
V
---------
A
V
F
-----
K
S
G
A
V
-
Q
D
-----------
P
----
S
F
F
G
L
Y
Q
--
A
L
S
NPDMVS
N
---
P
------
V
L
A
E
A
A
R
S
G
V
L
S
T
L
F
A
V
A
L
L
A
S
--
G
--
Q
N
S
T
I
-
T
---
G
T
---------
I
T
---
G
Q
-
V
------------
I
---
M
E
-
G
F
-
I
H
L
R
L
P
L
W
L
R
R
--------
L
V
T
R
L
I
---
A
I
I
P
V
V
V
C
V
A
--
I
T
S
H
Q
GSLD
E
H
----
Q
A
L
N
N
L
M
--
N
N
S
Q
V
F
L
A
L
A
L
P
F
S
I
V
----
P
L
L
M
L
--
T
--
D
S
A
A
QMGNQ
F
K
N
T
-----
R
W
----
V
K
V
M
G
W
L
T
V
I
I
L
T
L
L
N
-
L
-------
I
S
I
S
S
Q
I
----------------
4
HHSearch
63.22
14%
-164
- C4 -
-
5KTE
-
MNTH_DEIRA
A:
[27-412]
----------------------------------------------------
F
L
------
G
P
---
A
V
I
A
S
I
A
Y
M
D
P
G
---
N
F
A
T
N
I
E
G
G
A
R
Y
G
Y
S
L
---
L
W
V
I
-
L
A
A
N
-
L
M
A
M
V
I
Q
N
L
S
A
N
L
G
I
A
S
G
R
--
N
L
P
E
L
I
R
E
R
W
-
P
-
R
P
L
V
W
F
Y
W
I
-
Q
-
A
E
L
V
A
M
A
T
D
L
A
E
F
L
G
A
--------
A
L
A
I
Q
L
L
T
G
--
L
--
P
M
------
F
-
W
G
--
A
V
V
T
G
V
-
V
T
--
F
W
L
L
--------
E
L
A
V
---
G
A
F
V
L
M
I
G
V
A
Y
L
V
Q
V
V
L
A
--
R
--
P
D
L
A
A
V
G
A
G
F
---
V
---
P
-----
R
--
L
Q
G
---------
P
G
S
A
Y
L
A
V
G
I
I
-
G
A
T
V
M
P
H
V
-
I
-
Y
L
---------------------------------
L
N
R
V
D
---
V
I
A
---------
A
--
M
G
L
A
G
----------
L
I
N
---
M
S
M
L
A
V
A
A
---------
A
T
F
-----
H
G
K
N
V
-
E
--------------
N
A
G
D
L
T
T
A
Y
Q
--
T
L
---------------------
P
-----
A
A
S
V
L
F
A
V
A
L
L
A
S
--
G
--
L
S
S
S
A
-
V
---
G
T
---------
M
A
G
--
D
V
-
I
------------
M
---
Q
G
--------------------------
R
L
I
---
T
M
L
P
A
F
I
V
I
L
--
L
---------
G
----
M
D
P
S
S
V
L
--
I
L
S
Q
V
I
L
C
F
G
V
P
F
A
L
V
----
P
L
L
L
F
--
T
--
A
H
H
D
VMGA-
L
V
T
R
-----
R
S
----
F
T
V
I
G
W
V
I
A
V
I
I
I
A
L
N
-
G
-------
Y
----------------------
24
Fugue
60.44
22%
-70
* C3 *
-
5DXF
-
?
B:
[18-528]
P
K
E
F
E
G
K
G
KL
K
L
S
G
R
I
L
N
V
M
TSLPLQIVRGN
S
A
L
Y
S
S
Q
H
F
L
A
E
N
K
E
W
E
T
H
L
I
A
W
T
GDEE
D
K
S
---
K
I
E
K
K
L
C
D
A
S
G
T
P
N
I
H
P
V
W
L
L
R
R
D
Q
G
-
R
W
R
K
---
Y
A
E
N
-
V
L
W
P
-
V
F
H
Y
I
Q
P
S
D
G
K
A
E
T
D
A
W
H
D
Y
V
K
F
N
E
A
Y
L
N
-
K
-
I
-
K
S
V
Y
K
P
G
D
I
-
I
-
W
I
H
D
Y
Y
L
------
L
L
L
--------
P
Q
L
L
R
M
E
F
P
N
A
Y
--
I
G
-
F
-
F
L
H
------
V
P
-
F
P
S
-
S
E
--
Y
F
R
C
L
S
K
R
S
Q
L
L
D
G
M
L
GAD
K
I
G
F
Q
S
D
S
F
Q
R
H
F
I
S
C
C
A
--
R
V
L
G
C
E
--
V
N
R
D
S
---
V
---
S
-----
A
YG
T
T
I
--------
S
V
E
T
L
P
-----
I
-
G
I
D
T
E
K
I
E
-
H
D
A
F
S
-
S
E
L
G
V
---------
E
E
K
----------
V
Q
A
L
K
Q
V
Y
K
---
G
K
K
---------
L
--
I
V
G
R
D
R
LDKVRG
V
I
Q
K
L
E
---
G
F
E
I
F
L
D
M
Y
PEWRET
V
V
L
I
Q
V
S
S
P
G
Y
S
H
S
A
-
N
V
----------
E
T
R
V
T
E
I
I
S
R
I
N
S
--
K
Y
-------
G
---
N
LNHTP
V
L
H
Y
Q
-----
M
R
V
A
K
E
E
Y
L
A
L
L
R
--
V
AD
L
A
L
I
T
-
S
---
V
R
---------
D
G
------
M
------------
N
---
T
T
-
S
L
-
E
F
V
I
C
Q
K
Y
N
N
S
--------
P
--------------
L
I
L
S
--
E
F
--------
T
----
G
T
A
T
V
L
K
--
D
A
I
M
V
N
P
W
D
S
V
G
V
A
K
T
----
I
N
D
A
L
--
M
LS
T
K
E
K
-----
V
S
L
E
-----
S
K
----
L
Y
E
K
V
L
S
N
T
V
Q
N
W
T
S
T
F
I
-------
C
D
I
L
S
H
S
I
---------------
16
Fugue
60.00
12%
-140
- C4 -
-
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
------
A
V
---
G
V
M
I
G
A
S
I
F
S
-
I
---
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
---
I
L
S
G
-
I
Y
A
L
-
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
-
N
A
G
--
P
I
A
F
I
H
K
A
-
I
-
G
D
N
I
I
T
G
A
L
S
I
-
L
-
L
W
M
S
Y
V
I
S
I
A
L
F
A
K
G
F
--------
A
G
Y
F
L
P
L
I
N
--
A
--
P
I
N
T
-
F
N
I
A
-
I
T
--
E
I
-
G
I
V
-
A
F
--
F
T
A
L
N
F
F
G
S
K
A
-
V
G
R
A
---
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
--
G
L
I
T
I
H
--
P
S
Y
V
I
---
P
---
D
-----
L
--
A
P
S
--------
A
V
S
G
M
I
F
A
S
A
I
F
-
F
L
S
Y
M
G
F
G
-
V
I
T
N
A
-
S
E
H
I
E
---------
N
P
K
K
N
V
P
------
R
A
I
F
I
S
I
L
I
---
V
M
F
---------
V
--
Y
V
G
V
A
----------
I
S
A
I
G
N
L
P
I
D
E
L
I
K
---------
A
S
E
-----
N
A
L
A
V
-
A
A
----------
K
P
F
L
G
N
L
G
F
L
L
I
S
--
I
--------
G
---
A
------
L
F
S
I
-----
S
S
A
M
N
A
T
I
Y
G
G
A
N
--
V
--
A
Y
S
L
A
-
K
D
GE
L
P
---------
E
F
F
--
E
R
-
K
------------
V
WFK
S
T
-
E
G
-
L
Y
I
T
S
A
L
G
V
L
F
--------
A
L
L
F
N
M
E
G
V
A
S
I
T
S
A
V
F
M
V
--
I
Y
--------
L
----
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
----
V
V
L
G
V
--
F
--
L
L
L
L
-----
Y
Y
Q
W
-----
I
T
----
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
-
I
-------
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
NNMYVKS--
20
Fugue
49.51
14%
-57
- C2 -
-
4L9P
8
?
B:
[68-519]
----------------------------VHPGIP
A
L
F
R
E
P
P
L
I
H
D
L
L
S
T
E
T
T
E
L
------
Q
S
---
E
T
V
N
K
C
L
P
L
L
K
G
---
I
H
N
S
Q
K
G
P
F
N
K
Y
G
------------
I
P
A
-
L
Q
R
K
D
H
L
E
Y
L
Y
D
S
L
E
D
Y
P
A
--
S
F
V
A
L
D
A
S
-
R
-
P
-
W
M
V
Y
W
A
L
A
G
-
L
-
C
L
L
G
E
D
V
-
T
R
F
R
E
R
V
I
--------
S
T
F
T
A
A
Q
N
S
--
T
G
G
I
G
-
G
-
G
H
G
Q
-
M
S
H
V
A
S
-
S
Y
A
-
A
V
--
L
S
I
A
M
V
G
G
E
E
A
F
K
L
I
D
------------
R
K
A
M
W
K
W
L
G
--
K
L
K
Q
P
D
--
G
G
F
T
V
---
C
---
E
-----
G
--
G
E
E
--------
D
V
R
G
A
Y
C
A
M
V
V
H
-
A
L
L
D
L
P
L
A
-
L
P
P
-
E
-
A
E
A
R
Q
---------
N
G
L
E
T
F
T
------
D
G
L
P
E
Y
L
S
R
---
C
Q
T
YEGGISGSP
G
--
S
E
A
H
G
----------
A
Y
A
---
F
C
A
L
A
C
L
C
---------
L
L
G
-----
R
P
E
V
V
-
V
P
----------
R
Y
M
N
I
A
T
L
L
P
W
L
S
A
R
Q
Y
-------
A
PEG
G
------
F
S
G
R
-----
T
N
K
L
V
D
G
C
Y
S
H
W
V
G
N
C
--
W
P
L
V
Q
-
A
---
A
L
---------
D
G
T
--
Q
P
-
L
AG
P
K
R
S
S
VGNLY
S
---
R
E
-
G
L
T
R
Y
I
L
S
C
C
Q
C
K
L
G
G
L
R
DKPG
K
H
P
D
S
Y
H
T
C
Y
A
L
T
G
L
S
T
V
Q
--
Y
Y
--------
H
Y
C
T
D
S
S
V
S
S
K
D
--
D
F
S
S
A
F
S
W
K
H
D
P
N
F
A
S
DGQG
S
D
I
G
V
--
F
--
T
E
N
D
-----
R
L
V
P
-----
F
H
PIFV
I
P
H
K
S
A
E
D
I
R
V
W
F
E
N
Q
-
S
-------
F
D
L
--------------------
23
Fugue
39.51
37%
-162
- C1 -
-
1UHE
1
?
B:
[1-24]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
F
E
-
M
L
Y
S
K
---------
I
H
R
A
T
I
T
--------------
D
---
A
N
L
---------
N
--
Y
I
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
35.60
12%
-197
- C4 -
-
3OB6
-
ADIC_ECOLI
B:
[265-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-------
R
---
M
------
A
L
G
D
-----
T
A
G
A
I
V
S
F
C
A
A
A
G
--
C
--
L
G
S
L
G
-
G
---
W
T
---------
L
L
A
--
G
Q
-
T
------------
A
---
K
A
-
A
A
-
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
34.38
12%
-
- C4 -
-
2X79
-
HYUP_MICLQ
A:
[30-181]
-----------------------------------------------------
F
------
S
L
---
A
A
I
W
F
A
M
A
I
Q
V
A
---
I
F
I
A
A
G
Q
M
--
T
S
S
F
Q
V
W
Q
V
I
V
A
I
-
A
A
G
C
-
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
G
I
--
N
F
T
V
A
A
R
M
P
F
-
G
-
I
R
G
S
L
I
P
I
T
-
L
-
K
A
L
L
S
L
F
W
F
G
F
Q
T
W
L
G
--------
A
L
A
L
D
E
I
T
R
--
L
--
L
T
-
G
F
T
N
L
P
L
W
I
--
V
I
-
F
G
A
-
I
Q
--
V
-
V
T
T
F
Y
G
I
T
F
I
R
W
M
N
---
V
F
A
S
P
V
L
L
A
M
G
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
33.57
13%
-128
- C4 -
-
3DH4
1
?
A:
[54-355]
---------------------------------------------------
K
S
L
------
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
---
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
---
A
S
Y
E
-
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
G
I
Y
--
T
I
P
E
F
V
E
K
R
F
-
N
-
K
K
L
K
T
I
L
A
V
-
F
W
I
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
--------
G
L
A
L
E
T
I
L
G
--
I
--
P
L
------
M
-
Y
S
I
-
L
G
-
L
A
L
-
F
A
--
L
V
Y
S
I
------
V
V
W
T
D
---
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
-
G
G
T
DG
W
F
A
G
V
S
K
M
V
D
A
A
P
GHFEM
I
--
L
D
Q
SNP-----
Q
Y
M
N
L
P
G
I
A
V
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
-
Y
I
I
Q
-----------
R
T
L
A
A
-------
K
S
V
S
E
A
Q
K
G
---
I
V
F
---------
A
--
A
F
L
K
L
----------
I
V
P
---
F
L
V
V
L
P
G
I
A
A
-------
Y
V
I
-----
T
S
D
P
Q
-
L
M
A
S
L
GDIAATN
L
P
S
-
A
A
N
A
D
K
A
Y
P
--
W
L
-------
T
---
Q
------
F
L
P
V
-----
G
V
K
G
V
V
F
A
A
L
A
A
A
--
I
--
V
S
S
L
A
-
S
---
M
L
---------
N
S
T
--
A
T
-
I
------------
F
---
T
M
D
I
Y
-
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
33.34
21%
-178
- C4 -
-
3GIA
3
Y609_METJA
A:
[264-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
K
---
P
------
F
L
G
N
-----
L
G
F
L
L
I
S
I
G
A
L
F
S
--
I
--
S
S
A
M
N
-
A
---
T
I
---------
Y
G
G
--
A
N
-
V
------------
A
---
Y
S
-
L
A
-
K
D
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
33.16
18%
-41
- C3 -
-
5HDF
-
?
A:
[61-375]
-------------------------------------
S
A
I
C
R
A
T
T
V
E
V
T
L
G
K
G
T
------
G
K
M
W
-
G
E
L
C
R
P
A
G
S
S
P
D
---
T
V
V
T
-------------------
M
V
H
G
A
-
T
Y
N
H
N
Y
W
D
F
---------------------
P
-
Y
-
Q
P
D
K
Y
S
F
R
K
M
L
-
N
-------
G
A
G
Y
A
T
F
V
V
DRLGTGN
S
T
V
P
P
S
S
E
L
--
N
--
L
T
-
V
-
E
A
R
Q
M
H
E
--
V
V
-
Q
G
L
-
R
T
---------
G
R
I
G
G
T
G
F
G
---
K
V
V
L
A
G
Y
S
L
G
S
A
V
T
S
I
E
A
--
S
T
F
H
D
--------------------------------------
V
D
A
V
L
I
T
A
L
-
G
H
Y
N
N
P
A
G
-
T
Q
A
I
I
-
D
----------------
N
G
L
S
------
P
N
D
D
P
V
L
K
D
RHH
Y
D
D
---------
G
--
Y
A
T
T
K
----------
P
G
S
---------
R
K
---------
H
V
F
-----
Y
A
D
R
P
M
D
P
----------
G
V
L
A
T
D
E
L
T
K
------
D
-------
A
---
N
------
V
F
T
E
-----
A
A
D
P
L
V
I
D
P
A
V
S
R
--
A
--
I
D
V
P
V
M
F
---
A
L
G
DRDPLMCG
D
G
Y
--
E
D
C
S
------------
S
---
Q
A
-
A
L
-
R
A
Q
E
A
P
F
W
T
S
A
--------
P
S
F
D
V
I
L
V
E
D
A
G
H
G
L
N
L
V
P
--
N
--------------------------------------------------
T
--
R
V
Y
Q
-----
D
A
S
R
-----
D
W
----
L
D
R
V
V
G
H
G
----------------------------------------
9
HHSearch
29.68
21%
-139
- C4 -
-
3GI9
-
Y609_METJA
C:
[264-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
K
---
P
------
F
L
G
N
-----
L
G
F
L
L
I
S
I
G
A
L
F
S
--
I
--
S
S
A
M
N
-
A
---
T
I
---------
Y
G
G
--
A
N
-
V
------------
A
---
Y
S
-
L
A
-
K
D
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
29.63
12%
-131
- C4 -
-
5J4I
-
ADIC_ECOLI
A:
[265-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-------
R
---
M
------
A
L
G
D
-----
T
A
G
A
I
V
S
F
C
A
A
A
G
--
C
--
L
G
S
L
G
-
G
---
W
T
---------
L
L
A
--
G
Q
-
T
------------
A
---
K
A
-
A
A
-
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
24.51
12%
-157
- C4 -
-
2JLN
-
HYUP_MICLQ
A:
[30-181]
-----------------------------------------------------
F
------
S
L
---
A
A
I
W
F
A
M
A
I
Q
V
A
---
I
F
I
A
A
G
Q
M
--
T
S
S
F
Q
V
W
Q
V
I
V
A
I
-
A
A
G
C
-
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
G
I
--
N
F
T
V
A
A
R
M
P
F
-
G
-
I
R
G
S
L
I
P
I
T
-
L
-
K
A
L
L
S
L
F
W
F
G
F
Q
T
W
L
G
--------
A
L
A
L
D
E
I
T
R
--
L
--
L
T
-
G
F
T
N
L
P
L
W
I
--
V
I
-
F
G
A
-
I
Q
--
V
-
V
T
T
F
Y
G
I
T
F
I
R
W
M
N
---
V
F
A
S
P
V
L
L
A
M
G
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
24.09
18%
-25
* C4 *
-
5BRK
-
B:
[42-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
-
A
F
----------
K
F
F
M
E
Q
H
V
E
N
V
L
K
--
S
H
-------
Q
---
Q
------
R
L
H
R
-----
K
K
Q
L
E
N
E
M
M
R
V
-----------------------------
G
L
--
S
Q
-
D
------------
A
---
Q
D
-
Q
M
-
R
K
M
L
C
Q
K
E
S
N
Y
--------
I
R
L
K
R
A
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
19.00
25%
-95
- C4 -
-
5KTE
-
MNTH_DEIRA
A:
[27-160]
----------------------------------------------------
F
L
------
G
P
---
A
V
I
A
S
I
A
Y
M
D
P
G
---
N
F
A
T
N
I
E
G
G
A
R
Y
G
Y
S
L
---
L
W
V
I
-
L
A
A
N
-
L
M
A
M
V
I
Q
N
L
S
A
N
L
G
I
A
S
G
R
--
N
L
P
E
L
I
R
E
-
R
W
P
-
R
P
L
V
W
F
Y
W
I
-
Q
-
A
E
L
V
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------