@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0164: (2017-12-16 )
MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHEFFGGPHAERNALKNCRESPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLDCNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMSMDGKIATKTNQSKWITEEEARKHVHQLRHYVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRIICDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSSLMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISLPNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE
Atome Classification :
(20 SA)
.........10........20........30........40....----....50........60--..-----.......70........80........90........100.......110.....----..120.......130.......140.......150.......160.......170.......180.......190.......200.....------..210----.-........220......-.230..-.....240.......----250.......260.......270.......280.-.-.....290.......300.......310.......320.-.-......330.......340.......350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSD
S
K
Y
M
K
L
A
I
K
L
A
QKGAGYVNPNP
M
V
G
A
V
I
V
KDN
H
I
I
G
Q
G
Y
H
E
F----FGGPH
A
E
R
N
A
L
K
N
C
R
---ES-----PVG
A
T
L
Y
V
T
L
E
P
C
CHFGKTP
P
C
I
D
A
I
I
DSGI
T
R
V
V
I
GSLDCNPIVSGK
G
V
K
I
L
EE----NN
L
Q
V
T
V
G
I
L
E
N
E
C
L
N
L
I
K
S
F
R
K
Y
I
T
Q
HV
P
Y
V
F
M
K
Y
A
M
SMD
G
K
I
A
TKTNQSKWI
T
E
E
E
A
R
K
H
V
H
Q
L
R
H
Y
V
S
A
I
M
V
G
V
N
T
VIQDD
P
L
L
T
C
R
------LEE------G-KN
P
I
R
I
I
CDTHLRT
P
L
T
-
S
K
I
V
K
T
-
A
N
D
I
K
T
YIATSSEDK----
N
K
M
K
L
YQNHG
C
E
I
L
S
I
KKKGNHI
D
L
S
S
L
M
Q
H
LGN-M-QI
D
S
L
V
LEGGSLM
N
W
S
A
L
E
Q
Q
I
V
D
E
L
K
I
Y
I
A
P
K
IFG-GS-A-KFPVGGEGISLPND
A
I
R
LKP
Y
A
F
S
QIGN
D
Y
L
I
ES
E
V
IYPCSQE
76
HHSearch
88.49
39%
-69
* C4 *
-
4G3M
1
RIBD_BACSU
A:
[12-372]
S
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
------
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
-
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
--
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
K
-----
77
HHSearch
87.61
39%
-67
- C4 -
-
2B3Z
-
RIBD_BACSU
A:
[13-371]
-
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
------
V
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
-
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
--
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
------
65
Fugue
87.53
39%
-67
- C4 -
-
2B3Z
-
RIBD_BACSU
A:
[13-371]
-
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
--
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
------
4
PsiBlast_PDB
86.97
40%
-74
- C4 -
-
4G3M
1
RIBD_BACSU
A:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
1
PsiBlast_PDB
86.35
40%
-74
- C4 -
-
2B3Z
-
RIBD_BACSU
A:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
2
PsiBlast_PDB
86.09
40%
-72
- C4 -
-
2D5N
-
RIBD_BACSU
A:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
21
PsiBlast_CBE
86.04
40%
-76
- C4 -
-
4G3M
2
RIBD_BACSU
D:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
3
PsiBlast_PDB
85.38
40%
-73
- C4 -
-
3EX8
-
RIBD_BACSU
A:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
22
PsiBlast_CBE
85.22
40%
-72
- C4 -
-
4G3M
2
RIBD_BACSU
C:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
29
PsiBlast_CBE
85.19
40%
-75
- C4 -
-
2D5N
1
RIBD_BACSU
B:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
25
PsiBlast_CBE
85.12
40%
-76
- C4 -
-
3EX8
1
RIBD_BACSU
C:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
23
PsiBlast_CBE
84.67
40%
-69
- C4 -
-
4G3M
2
RIBD_BACSU
B:
[17-363]
-----
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
----
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
G
---
A
H
-----
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
----
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
------
L
P
N
V-----
T
-
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
-
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
----
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
--
R
I
Q
I
P
D
V
L
K
I
L
A
E
-
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
Y
F
A
P
K
L
I
G
-
G
T
H
A
-
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
--------------
80
HHSearch
83.30
36%
-62
- C4 -
-
3ZPG
2
?
A:
[26-378]
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
G
---
E
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
----
A
G
I
E
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
--
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
------
S
L
H
NIDIET
V
-
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
----
P
E
T
V
M
V
M
G
P
Y
--------
R
Q
E
L
A
D
L
G
V
I
Q
L
E
------
I
Q
P
L
K
T
L
L
Q
T
L
S
K
Q
Y
-
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
-
Q
S
-
A
-
R
A
-
M
F
N
A
D
F
E
Y
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
------
79
HHSearch
82.81
36%
-64
- C4 -
-
3ZPC
-
?
A:
[26-379]
K
Q
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
G
---
E
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
----
A
G
I
E
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
------
S
L
H
NIDIET
V
-
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
----
P
E
T
V
M
V
M
G
P
Y
--------
R
Q
E
L
A
D
L
G
V
I
Q
L
E
------
I
Q
P
L
K
T
L
L
Q
T
L
S
K
Q
Y
-
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
-
Q
S
-
A
-
R
A
-
M
F
N
A
D
F
E
Y
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
Q
-----
81
HHSearch
79.28
41%
-11
- C4 -
-
2HXV
9
?
A:
[13-357]
-
M
Y
E
T
F
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
----
F
G
G
P
H
A
E
R
M
A
I
E
S
A
R
---
K
K
GED--
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
V
-
S
G
N
G
V
E
K
F
R
N
----
H
G
I
E
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
D
K
-
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
------
L
K
E
------
G
-
R
N
P
V
R
V
I
L
D
R
K
G
V
L
S
G
K
V
F
R
V
F
E
--
E
-
N
A
R
V
I
V
F
T
E
S
E
E
A
----
E
Y
-----
P
P
H
V
E
K
A
L
-----
S
D
C
S
V
E
S
I
L
R
N
L
Y
E
-
R
-
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
--
A
D
V
V
F
G
F
Y
S
T
K
I
F
G
-
K
G
-
L
-
D
--
V
F
S
G
Y
L
S
D
V
S
V
P
P
K
F
K
V
V
N
V
E
F
S
D
S
E
F
L
V
E
M
R
P
C
------
5
PsiBlast_PDB
78.88
41%
-8
- C4 -
-
2HXV
9
?
A:
[17-357]
-----
F
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
----
F
G
G
P
H
A
E
R
M
A
I
E
S
A
R
K
K
G
E
D
-----
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
-
V
S
G
N
G
V
E
K
F
R
N
----
H
G
I
E
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
-
D
K
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
------
L
K
E
------
G
-
R
N
P
V
R
V
I
L
D
R
--
K
G
V
L
S
-
G
K
V
F
R
V
F
E
E
N
A
R
V
I
V
F
T
E
S
E
E
A
----
E
----
Y
P
P
H
------
V
E
K
A
L
S
D
C
S
V
E
S
I
L
R
N
L
Y
E
-
R
-
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
--
A
D
V
V
F
G
F
Y
S
T
K
I
F
G
K
G
L
-
D
-
V
F
S
G
Y
L
S
D
V
S
V
P
-
P
K
F
K
V
V
N
V
E
F
S
D
--
S
E
F
L
V
E
M
R
---
P
C
---
7
PsiBlast_PDB
77.37
37%
-60
- C4 -
-
3ZPG
2
?
A:
[28-343]
--
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
G
---
E
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
----
A
G
I
E
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
--
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
SLHNID
I
E
T
------
V
-
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
-
P
E
T
V
M
V
---------------
M
G
P
Y
R
Q
E
L
A
D
L
G
V
I
Q
L
E
I
Q
--
P
L
K
T
L
L
Q
T
L
S
K
-
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
-
Q
S
-
A
-
R
------------------------------------------
6
PsiBlast_PDB
76.95
37%
-61
- C4 -
-
3ZPC
-
?
A:
[28-343]
--
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
----
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
G
---
E
Q
-----
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
----
A
G
I
E
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
SLHNID
I
E
T
------
V
-
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
-
P
E
T
V
M
V
---------------
M
G
P
Y
R
Q
E
L
A
D
L
G
V
I
Q
L
E
I
Q
--
P
L
K
T
L
L
Q
T
L
S
K
-
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
Y
V
A
P
T
L
L
G
-
Q
S
-
A
-
R
------------------------------------------
91
HHSearch
51.93
36%
-69
- C4 -
-
1Z3A
-
TADA_ECOLI
B:
[8-158]
-
S
H
E
Y
W
M
R
H
A
L
T
L
A
K
R
A
W
--
D
E
R
E
V
P
V
G
A
V
L
V
H
N
N
R
V
I
G
E
G
W
N
R
P
IGRH
D
P
T
A
H
A
E
I
M
A
L
R
Q
G
G
---
L
V
MQNYR
L
I
D
A
T
L
Y
V
T
L
E
P
C
------
V
M
C
A
G
A
M
I
H
S
R
I
G
R
V
V
F
G
A
R
D
A
K
T
G
A
A
G
S
L
M
D
V
L
H
H
PGMN
H
R
V
E
I
T
E
G
I
L
A
D
E
C
A
A
L
L
S
D
F
F
R
M
R
R
Q
E
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
51.52
38%
-15
- C4 -
-
2AZN
4
RIB7_METJA
A:
[2-219]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
P
Y
I
I
S
N
V
G
M
T
L
D
G
K
L
A
T
I
N
N
D
S
-
R
I
S
C
E
E
D
L
I
R
V
H
K
I
R
A
N
V
D
G
I
M
V
G
I
G
T
V
L
K
D
D
P
R
L
T
V
H
------
K
I
K
S-----
D
-
R
N
P
V
R
I
V
V
D
S
K
L
R
V
P
L
N
-
A
R
V
L
N
K
---
D
A
K
T
I
I
A
T
T
E
D
T
N
E
E
K
E
K
K
I
K
I
L
E
D
M
G
V
E
V
V
K
C
G
R
--
G
K
V
D
L
K
K
L
M
D
I
L
Y
D
-
K
-
G
I
K
S
I
L
L
E
G
G
G
T
L
N
W
G
M
F
K
E
G
L
V
D
E
V
S
V
Y
I
A
P
K
I
F
G
-
G
K
-
E
A
P
T
Y
V
D
G
E
G
F
K
T
V
D
E
C
V
K
L
E
L
K
N
F
Y
R
L
G
E
G
I
V
L
E
F
K
V
K
K
-----