@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0183: (2017-12-16 )
MRMIALEEKITILPTLFVEKRDGRRVVFDVDKIDKALHTAADKVMDVTPLVEKRLNDLTERIITEIHSRFPQGIKIYEIQNIVEHELLEAKEYALAEEYITYRTQRDFERSKATDINFSIHKLLNKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLQMLPKHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLENGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRIDEILAPYAEKNYQKHLKDAEEWVLPEKQEDYAWKKAQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSRFEREIQKAILNIRIKGLGSEHRTAIFPKLIFTLKRGLNLEEGTPNYDIKQLALECATKRMYPDVLSYDKIVDLTGSFKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESEGDMNKFWEIFNERMNIAEDALVYRVERTKEATPANAPILYQYGAFGHRLGKEESVDQLFKNRRATVSLGYIGLYEVATVFFGNSWESNPDAKEFTLDIIHDMKRRVEEWSDQYGYHFSIYSTPSESLTDRFCRLDIDKFGSIPDITDKEYYTNSFHYDVRKNPTPFEKLDFEKVYPEAGASGGFIHYCEYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDRCYKCDFEGDFEPTERGFACPNCGNSDPKTVDVVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIKIAGHQVTN
Atome Classification :
(20 SA)
.........10........20........30........40........50......----..60........70..------......80........90........100.......110.......120----........130.......140.......150.......160..---....----.170.......180.....--..190.......200...-.-...210.......220.-......230...-..-..240.......250.......260.......270.......----------------------------280.......290..--.....300--------......------...310.....---..320.....----------------..330.....------------------------..340...-.....350-.....-----..--------------------.360.......370....-.-.-------------------------------.380.....------------------..390-.-----.------..--..--..400.......410--...------..-....--420--..-----------...---....430.....----.--------------------.------440...----....450.......460-.........470.......--480...--....490.......500---.-........510.......520----------------------------------------------------------.-------------------------------------..-.------....530...----------....540.......550------------------------------------------.........560....--.---..----------..570....---..-----.580---.----.......------------590-------..-.....-.-600.......610....-...620.......630.---..----.....640.....-..650-.......660--........670.......680.......690.......700.......710.......720...--....730.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
M
I
A
LEE
K
I
T
I
L
P
T
L
F
V
EKRDG
R
R
V
V
F
D
V
D
K
I
D
K
A
L
H
T
A
A
D
K
VM
D
V
T
P
L
V
E
K
R
L
N
D
----
L
T
E
R
I
I
T
E
I
H
S
RFPQG------
I
K
I
Y
E
I
Q
N
I
V
E
H
E
L
L
E
A
K
E
Y
A
L
A
E
E
Y
I
T
Y
R
T
QRDFERSKATDI
N
F
S
I
H
-----
K
L
LNK
D
Q
T
V
VNENANKDSDVFNT
Q
R
D
L
T
A
G
I
V
G
K
S
I
G
L
Q
M
L
P
K
---
H
V
AN----AHQKGD
I
H
Y
HDLDYSPYTP--MT
N
C
C
L
I
D
F
K
G
M
LENGFK-I-GNAEVESPKS
I
Q
T
A
T
A
Q
-
I
S
Q
I
I
A
N
V
A
SSQ-YG-GC
S
A
D
R
I
D
E
I
L
A
P
Y
A
E
K
N
Y
Q
K
H
L
K
D
A
E
E
WVLPEKQE
D
Y
A
W
K
K
----------------------------
A
Q
K
D
I
Y
D
A
M
Q
S
L
E
Y
E
--
I
N
T
L
F
T----------SNGQTP------F
T
S
LGFGL
G
T
S
---
R
F
E
R
E
I
Q
K
A
I
----------------
L
N
I
R
I
K
GLGS------------------------
E
H
R
-
T
A
I
F
-
P
K
L
I
F
T
L
--
K
RGLN-----LE--------------------EGTPN
Y
D
I
K
Q
L
A
L
E
C
A
T
K
-R-M-------------------------------YPDVLSYD
K
------------------
I
V
DL--T-----G------SF--KV--
P
M
G
C
R
S
F
L
Q
GWKD----EN
G
------
V
E
-VNSG--
R
----
M
N
-----------
L
G
V
---
V
T
VNL
P
R
I
A
LES----E--------------------G------
D
M
N
K
F
W
----
E
I
F
N
E
R
MNI
A
E
D
A
L
V
---
Y
R
V
ERTKEATPANA
P
I
L
Y
Q--YGAFGH--RLGK
E
E
S
V
D
Q
L
F
KNR-----R-
A
T
V
S
L
G
Y
I
G
L
Y
E
V
A
T
V
F
FGN-----------------------------------------------------------S-------------------------------------WE-S------NPD
A
K
E
F
T
L
D
----------
I
I
H
D
M
K
R
R
V
E
E
W
S
DQ--------------------------------------------Y
G
Y
H
F
S
I
YST--P
S
E
S
--
L
---
T
D
----------
R
F
C
RL
D
I
D
K---FG-----SIP----D----ITDKEYY------------TN--------S
F
-
H
Y
DVR-K-NPTPFEKL
D
F
E
K
VYPEA-GASGG
F
I
H
YCEYPVL-Q---QN----
P
K
A
L
E
A
V
W
D
Y
A
Y
D
-RVGYL-GTNT
P
I
D
R
C
---
Y
KCDFEGDFEPTERGFACPNCGNSDP
K
T
V
D
V
V
K
R
T
C
GYLGNPQARPMVNG
R
H
K
E
I
A
A
R
V
KHMNG--
S
T
I
K
IAGHQVTN
15
HHSearch
84.85
53%
-22
- C3 -
-
1H7A
1
NRDD_BPT4
A:
[27-589]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
-
D
A
L
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
G
Q
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
SS----
V
P
--
V
S
--
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
----
Y
--------------------
I
GTQF--
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
-
L
V
----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
H
-
F
-
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
---
F
T
C
G
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
R
G
--------------------------------
5
PsiBlast_PDB
84.63
52%
-18
- C3 -
-
1HK8
2
NRDD_BPT4
A:
[26-586]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
G
Q
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
------
S
S
V
P
V
S
--
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
YIGT
Q
--------------------
F
------
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
-
H
F
-
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
---
F
T
C
G
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
-----------------------------------
39
Fugue
84.50
53%
-20
- C3 -
-
1H7A
1
NRDD_BPT4
A:
[27-589]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
-
D
A
L
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
G
Q
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
------
S
S
--
V
P
V
S
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
----
Y
IGTQ----------------
F
------
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
H
F
I
--
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
---
F
T
C
G
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
R
G
--------------------------------
1
PsiBlast_PDB
84.22
52%
-19
- C3 -
-
1H79
2
NRDD_BPT4
A:
[27-585]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
G
Q
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
------
S
S
V
P
V
S
--
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
YIGT
Q
--------------------
F
------
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
-
H
F
-
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
---
F
T
C
G
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
------------------------------------
4
PsiBlast_PDB
84.15
52%
-23
- C3 -
-
1H78
2
NRDD_BPT4
A:
[26-587]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
--
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
------
S
S
V
P
V
S
--
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
YIGT
Q
--------------------
F
------
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
-
H
F
-
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
---
F
T
--------------------------
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
----------------------------------
2
PsiBlast_PDB
83.98
52%
-19
- C3 -
-
1H7A
1
NRDD_BPT4
A:
[27-589]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
G
Q
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
------
S
S
V
P
V
S
--
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
YIGT
Q
--------------------
F
------
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
-
H
F
-
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
---
F
T
C
G
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
R
G
--------------------------------
3
PsiBlast_PDB
83.36
52%
-24
- C3 -
-
1H7B
-
NRDD_BPT4
A:
[26-587]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
---
F
I
M
K
----
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
--
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
-
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
-
M
A
Q
I
T
A
Q
V
A
S
H
Q
-
Y
G
-
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
----------------------------
T
E
K
D
V
Y
D
A
F
Q
A
Y
E
Y
E
--
V
N
T
L
F
S
----------
S
N
G
Q
T
P
------
F
V
T
I
T
F
G
T
G
T
D
---
W
T
E
R
M
I
Q
K
A
I
----------------
L
K
N
R
I
K
G
L
G
R
------------------------
D
G
I
-
T
P
I
F
-
P
K
L
V
M
F
V
--
E
E
G
V
N
-----
L
Y
--------------------
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
-
M
-------------------------------
Y
P
D
I
I
S
A
K
N
------------------
N
K
A
I
--
T
-----
G
------
S
S
V
P
V
S
--
P
M
G
C
R
S
F
L
S
V
W
K
D
----
S
T
G
------
N
E
-
I
L
D
G
--
R
----
N
N
-----------
L
G
V
---
V
T
L
N
L
P
R
I
A
L
D
S
YIGT
Q
--------------------
F
------
N
E
Q
K
F
V
----
E
L
F
N
E
R
M
D
L
C
F
E
A
L
M
---
C
R
I
S
S
L
K
G
V
K
A
T
V
A
P
I
L
Y
Q
--
E
G
A
F
G
V
--
R
L
K
P
D
D
D
I
I
E
L
F
K
N
G
-----
R
-
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-----------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
----------
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
--------------------------------------------
T
G
F
A
F
S
L
Y
S
T
--
P
A
E
N
--
L
---
C
Y
----------
R
F
C
K
L
D
T
E
K
---
Y
G
-----
S
V
K
----
D
----
V
T
D
K
G
W
Y
------------
T
N
--------
S
F
-
H
V
S
V
E
-
E
-
N
I
T
P
F
E
K
I
S
R
E
A
P
Y
-
H
F
-
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
-
K
---
N
N
----
L
K
G
L
E
A
V
W
D
Y
A
A
Q
-
H
L
D
Y
F
-
G
V
N
M
P
V
D
K
C
-------------------------------
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
----------------------------------
7
PsiBlast_PDB
50.24
22%
20
- C3 -
-
4COM
2
?
A:
[92-623]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
F
G
K
---
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
--
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
-
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
-
V
I
Q
F
V
M
-
F
A
S
N
Q
-
S
S
-
G
A
V
G
L
P
D
F
F
V
W
M
W
Y
F
V
K
------
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-----------------------------------
I
E
Q
H
F
Q
I
L
T
Y
S
--
L
N
Q
P
I
R
----------
T
T
-
Q
S
P
------
Y
T
N
F
T
Y
---------
L
D
R
N
Y
I
K
A
I
----------------
F
E
G
E
R
Y
P
D
G
S
LITDH
V
E
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
-
M
F
T
F
-
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
-----
L
D
--------------------
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
-
W
-------------------------------
Y
I
S
----
D
S
------------------
I
D
A
V
--
A
-----
S
------
C
C
---------------------------------
E
-
K
L
K
G
--
R
----
M
N
SIGGSDLNIGS
F
K
V
---
I
T
V
N
L
P
R
I
A
L
E
S
----
G
--------------------
G
------
D
R
E
K
Y
L
----
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
---
A
V
R
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
--
N
G
----------------
L
M
L
L
N
-----
R
-
Q
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------------------------------
T
-------------------------------------
T
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
----------
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
--------------------------------------------
Y
G
F
T
F
N
I
E
Q
V
--
P
A
E
K
--
A
---
A
V
----------
T
L
A
Q
K
D
R
F
L
---
F
G
-----
E
K
Q
----
P
----
F
---
E
I
Y
------------
S
N
--------
Q
W
--
V
P
L
M
-
A
-
N
T
D
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
-
V
S
G
G
A
I
L
H
I
N
L
G
E
S
F
-
K
---
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
-
G
V
M
Y
F
-
A
F
N
T
K
I
S
V
C
---
E
----
D
G
H
A
F
Y
G
E
R
---
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
---------------------------------------
9
PsiBlast_PDB
49.30
22%
15
- C3 -
-
4COJ
3
?
A:
[92-623]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
F
G
K
---
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
--
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
-
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
-
V
I
Q
F
V
M
-
F
A
S
N
Q
-
S
S
-
G
A
V
G
L
P
D
F
F
V
W
M
W
Y
F
V
K
------
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-----------------------------------
I
E
Q
H
F
Q
I
L
T
Y
S
--
L
N
Q
P
I
R
----------
T
T
-
Q
S
P
------
Y
T
N
F
T
Y
---------
L
D
R
N
Y
I
K
A
I
----------------
F
E
G
E
R
Y
P
D
G
S
LITDH
V
E
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
-
M
F
T
F
-
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
-----
L
D
--------------------
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
-
W
-------------------------------
Y
I
S
----
D
S
------------------
I
D
A
V
--
A
-----
S
------
C
C
---------------------------------
E
-
K
L
K
G
--
R
----
M
N
SIGGSDLNIGS
F
K
V
---
I
T
V
N
L
P
R
I
A
L
E
S
----
G
--------------------
G
------
D
R
E
K
Y
L
----
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
---
A
V
R
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
--
N
G
----------------
L
M
L
L
N
-----
R
-
Q
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------------------------------
T
-------------------------------------
T
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
----------
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
--------------------------------------------
Y
G
F
T
F
N
I
E
Q
V
--
P
A
E
K
--
A
---
A
V
----------
T
L
A
Q
K
D
R
F
L
---
F
G
-----
E
K
Q
----
P
----
F
---
E
I
Y
------------
S
N
--------
Q
W
--
V
P
L
M
-
A
-
N
T
D
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
-
V
S
G
G
A
I
L
H
I
N
L
-----
K
---
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
-
G
V
M
Y
F
-
A
F
N
T
K
I
S
V
C
---
E
----
D
G
H
A
F
Y
G
E
R
---
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
---------------------------------------
10
PsiBlast_PDB
47.90
22%
19
- C3 -
-
4COL
3
?
A:
[92-623]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
F
G
K
---
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
--
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
-
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
-
V
I
Q
F
V
M
-
F
A
S
N
Q
-
S
S
-
G
A
V
G
L
P
D
F
F
V
W
M
W
Y
F
V
K
------
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-----------------------------------
I
E
Q
H
F
Q
I
L
T
Y
S
--
L
N
Q
P
I
R
----------
T
T
-
Q
S
P
------
Y
T
N
F
T
Y
---------
L
D
R
N
Y
I
K
A
I
----------------
F
E
G
E
R
Y
P
D
G
S
LITDH
V
E
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
-
M
F
T
F
-
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
-----
L
D
--------------------
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
-
W
-------------------------------
Y
I
S
----
D
S
------------------
I
D
A
V
--
A
-----
S
-------------------------------------------
K
L
K
G
--
R
----
M
N
SIGGSDLNIGS
F
K
V
---
I
T
V
N
L
P
R
I
A
L
E
S
----
G
--------------------
G
------
D
R
E
K
Y
L
----
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
---
A
V
R
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
--
N
G
----------------
L
M
L
L
N
-----
R
-
Q
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------------------------------
T
-------------------------------------
T
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
----------
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
--------------------------------------------
Y
G
F
T
F
N
I
E
Q
V
--
P
A
E
K
--
A
---
A
V
----------
T
L
A
Q
K
D
R
F
L
---
F
G
-----
E
K
Q
----
P
----
F
---
E
I
Y
------------
S
N
--------
Q
W
--
V
P
L
M
-
A
-
N
T
D
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
-
V
S
G
G
A
I
L
H
I
N
L
---------
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
-
G
V
M
Y
F
-
A
F
N
T
K
I
S
V
C
---
E
----
D
G
H
A
F
Y
G
E
R
---
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
---------------------------------------
6
PsiBlast_PDB
47.20
22%
31
- C3 -
-
4COI
3
?
A:
[92-623]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
F
G
K
---
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
--
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
-
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
-
V
I
Q
F
V
M
-
F
A
S
N
Q
-
S
S
-
G
A
V
G
L
P
D
F
F
V
W
M
W
Y
F
V
K
------
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-----------------------------------
I
E
Q
H
F
Q
I
L
T
Y
S
--
L
N
Q
P
I
R
----------
T
T
-
Q
S
P
------
Y
T
N
F
T
Y
---------
L
D
R
N
Y
I
K
A
I
----------------
F
E
G
E
R
Y
P
D
G
S
LITDH
V
E
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
-
M
F
T
F
-
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
-----
L
D
--------------------
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
-
W
-------------------------------
Y
I
S
----
D
S
------------------
I
D
A
V
--
A
-----
S
------
C
C
--
R
------------------------------
E
-
K
L
K
G
--
R
----
M
N
SIGGSDLNIGS
F
K
V
---
I
T
V
N
L
P
R
I
A
L
E
S
----
G
--------------------
G
------
D
R
E
K
Y
L
----
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
---
A
V
R
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
--
N
G
----------------
L
M
L
L
N
-----
R
-
Q
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------------------------------
T
-------------------------------------
T
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
----------
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
--------------------------------------------
Y
G
F
T
F
N
I
E
Q
V
--
P
A
E
K
--
A
---
A
V
----------
T
L
A
Q
K
D
R
F
L
---
F
G
-----
E
K
Q
----
P
----
F
---
E
I
Y
------------
S
N
--------
Q
W
--
V
P
L
M
-
A
-
N
T
D
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
-
V
S
G
G
A
I
L
H
I
N
L
G
E
S
F
-
K
---
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
-
G
V
M
Y
F
-
A
F
N
T
K
I
S
V
C
---
E
----
D
G
H
A
F
Y
G
E
R
---
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
---------------------------------------
8
PsiBlast_PDB
43.68
22%
25
- C3 -
-
4CON
1
?
A:
[92-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
F
G
K
---
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
--
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
-
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
-
V
I
Q
F
V
M
-
F
A
S
N
Q
-
S
S
-
G
A
V
G
L
P
D
F
F
V
W
M
W
Y
F
V
K
------
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-----------------------------------
I
E
Q
H
F
Q
I
L
T
Y
S
--
L
N
Q
P
-------------
T
-
Q
S
P
------
Y
T
N
F
T
Y
---------
L
D
R
N
Y
I
K
A
I
----------------
F
E
G
E
R
Y
P
D
G
S
LITDH
V
E
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
-
M
F
T
F
-
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
-----
L
D
--------------------
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
-
W
-------------------------------
Y
I
S
----
D
S
------------------
I
D
A
V
--
A
-----------------------------------------------
E
-
K
L
K
G
--
R
----
M
N
SIGGSDLNIGS
F
K
V
---
I
T
V
N
L
P
R
I
A
L
E
S
----
G
--------------------
G
------
D
R
E
K
Y
L
----
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
---
A
V
R
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
--
N
G
----------------
L
M
L
L
N
-----
R
-
Q
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------------------------------
T
-------------------------------------
T
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
----------
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
--------------------------------------------
Y
G
F
T
F
N
I
E
Q
V
--
P
A
E
K
--
A
---
A
V
----------
T
L
A
Q
K
D
R
F
L
---
F
G
-----
E
K
Q
----
P
----
F
---
E
I
Y
------------
S
N
--------
Q
W
--
V
P
L
M
-
A
-
N
T
D
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
-
V
S
G
G
A
I
L
H
I
N
------
K
---
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
-
G
V
M
Y
F
-
A
F
N
---------------------------------------------------------------------------------------
14
PsiBlast_CBE
43.41
37%
-40
* C4 *
-
5IM3
2
?
B:
[32-153]
---------------
L
R
V
I
K
R
N
G
T
V
V
P
Y
T
D
D
K
I
T
V
A
I
T
K
A
F
L
A
V
E
---
A
A
A
S
S
R
I
H
D
T
V
R
R
L
T
E
Q
V
T
A
T
F
K
R
R
M
P
S
G
G
T
----
I
H
I
E
E
I
Q
D
Q
V
E
L
A
L
M
R
A
G
E
Q
K
V
A
R
D
Y
V
I
Y
R
E
A
R
A
A
E
R
K
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
40.35
37%
-40
- C4 -
-
5IM3
2
?
A:
[32-142]
---------------
L
R
V
I
K
R
N
G
T
V
V
P
Y
T
D
D
K
I
T
V
A
I
T
K
A
F
L
A
V
E
G
G
T
A
A
A
S
S
R
I
H
D
T
V
R
R
L
T
E
Q
V
T
A
T
F
K
R
R
M
P
S
G
G
T
----
I
H
I
E
E
I
Q
D
Q
V
E
L
A
L
M
R
A
G
E
Q
K
V
A
R
D
Y
V
I
Y
R
E
A
R
A
A
E
R
K
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
36.13
12%
-52
- C3 -
-
3O0Q
2
?
B:
[240-630]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
N
L
S
V
G
F
P
M
D
---
K
------
K
E
I
----------------
L
K
L
Y
E
E
D
G
E
---------------------------
L
-
E
L
S
H
-
P
R
S
T
--
I
--
R
K
K
V
-------------------------------
K
I
R
E
L
F
R
K
I
A
T
N
A
W
K
-
S
-
G
-------------------------------
D
P
G
L
A
F
L
G
E
------------------
M
N
K
Y
--
Y
-----
P
-----------
L
--
Y
P
H
R
K
I
N
S
T
N
P
C
-------
G
------
E
I
-
G
L
S
D
--
Y
----
E
A
-----------
C
N
L
---
G
S
I
D
V
A
K
F
Y
N
N
G
----
F
--------------------
V
------
D
----
L
----
E
A
L
Q
E
L
V
Q
I
A
V
R
F
L
D
---
N
V
I
D
V
------
N
V
F
P
I
D
K
I
--
T
---------------
K
A
V
K
E
S
--------
R
R
L
G
L
G
I
M
G
F
A
D
L
L
Y
K
L
-
E
I
-----------------------------------------------------------
P
-------------------------------------
Y
--
N
------
S
Q
E
A
R
D
F
A
A
N
----------
L
M
A
F
I
A
L
H
A
H
R
T
S
Y
E
L
G
K
E
KGNFPLLEISRYRTEDNFVPFAMGMSNY
D
D
E
I
R
E
V
M
K
M
T
K
E
F
R
R
N
V
A
L
L
T
I
A
P
T
G
S
--
I
---
S
N
I
A
DTSSGLEP
N
F
L
L
A
Y
T
R
F
-----------
L
L
YVN
Q
V
L
R
E
K
L
N
P
E
I
L
K
R
I
E
K
E
L
I
E
K
GSL
K
D
IPDVP
E
K
I
K
K
-
V
F
V
V
A
-
L
-
D
I
D
P
M
D
H
L
L
M
Q
D
A
F
Q
-
R
-
Y
V
D
N
N
I
S
K
T
I
N
M
P
Q
S
-
A
----
T
----
V
D
D
V
L
N
V
Y
L
E
A
L
R
T
N
V
R
G
I
-
T
V
Y
R
D
-------------------------------------------------------------------------------------
11
PsiBlast_PDB
34.84
25%
5
- C3 -
-
4U3E
1
?
A:
[381-643]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------
S
D
-
L
N
I
G
--------
S
-----------
F
K
V
---
I
T
V
N
L
P
R
I
A
L
E
S
----
G
--------------------
G
------
D
R
E
K
Y
L
----
Q
I
L
R
H
R
V
Q
L
I
K
K
A
L
A
---
A
V
R
E
I
I
K
E
R
I
S
E
G
L
L
P
L
Y
E
--
N
G
----------------
L
M
L
L
N
-----
R
-
Q
Y
G
T
I
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------------------------------
T
-------------------------------------
T
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
----------
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
--------------------------------------------
Y
G
F
T
F
N
I
E
Q
V
--
P
A
E
K
--
A
---
A
V
----------
T
L
A
Q
K
D
R
F
L
---
F
G
-----
E
K
Q
----
P
----
F
---
E
I
Y
------------
S
N
--------
Q
W
--
V
P
L
M
-
A
-
N
T
D
V
L
N
R
I
R
Y
S
G
K
W
D
K
K
-
V
S
G
G
A
I
L
H
I
N
L
G
E
S
F
-
K
---
T
E
----
E
E
S
F
N
M
V
K
M
I
A
D
M
-
G
V
M
Y
F
-
A
F
N
T
K
I
S
V
C
---
E
----
D
G
H
A
F
Y
G
E
R
---
C
P
V
C
G
K
A
---
K
V
D
E
Y
M
R
I
V
G
Y
L
---------------------------------------
43
Fugue
34.39
20%
42
- C3 -
-
5IM3
4
?
A:
[32-912]
---------------
L
R
V
I
K
R
N
G
T
V
V
P
Y
T
D
D
K
I
T
V
A
I
T
K
A
F
L
A
V
E
G
G
T
A
A
A
S
S
R
I
H
D
----
T
V
R
R
L
T
E
Q
V
T
A
T
F
K
R
R
M
PS
G
G
T
I
H
I
E
E
I
Q
D
Q
V
E
L
A
L
M
R
A
G
E
Q
K
V
A
R
D
Y
V
I
Y
R
E
A
R
A
A
E
R
K
N
A
G
A
A
S
D
V
A
Q
P
H
P
S
I
R
I
T
R
A
D
G
S
L
S
P
L
D
M
G
R
L
N
T
I
I
S
E
A
C
E
G
L
A
E
V
D
G
A
L
I
E
R
E
T
L
K
N
LYD
G
V
A
E
----
K
D
V
N
T
A
L
V
M
T
A
R
T
L
V
E
R
E
P
N
Y
S
Y
V
T
A
R
L
L
M
D
T
L
R
A
E
A
L
G
-
F
L
G
V
A
E
S
A
T
H
H
E
M
A
E
L
Y
A
K
A
L
P
A
Y
I
E
K
G
A
E
F
E
-
L
V
-
D
A
K
L
K
E
F
D
--
L
E
K
L
G
K
A
I
D
H
E
R
D
Q
Q
F
T
Y
L
G
L
Q
T
L
Y
D
R
Y
F
I
H
K
DGIRFEL
P
Q
I
F
F
M
R
V
A
M
G
L
A
I
EEKD
R
E
A
R
A
I
E
F
Y
N
L
L
S
S
F
D
Y
M
SS
T
P
T
L
F
N
----------
A
G
T
L
R
P
QLSS
C
Y
L
T
T
V
P
D
D
L
S
G
I
---
Y
G
A
I
H
D
N
A
M
L
S
K
FA
G
G
L
G
N
D
WTPVRA
L
G
S
Y
I
K
G
T
N
G
------------------------
K
S
Q
G
V
V
P
F
-
L
K
V
V
N
D
T
--
A
V
A
V
N
A
V
C
A
Y
L
E
TWHLD
I
E
E
F
L
E
LRKNTGDDR
R
R
T
H
D
M
N
T
A
N
W
I
P
D
L
F
M
K
-
R
-
V
F
D
D
G
S
W
T
L
F
S
PSDVPDLHDLYG
K
A
F
E
E
R
Y
E
Y
Y
E
A
L
A
S
Y
G
K
LK
L
H
K
V
V
Q
A
K
D
L
W
R
K
M
L
S
M
L
F
E
--
T
-----
G
HP
W
L
--
T
F
--
K
D
--
P
C
N
L
R
S
P
Q
Q
H
V
G
V
----
V
H
S
SNLCTE
I
T
-
L
N
T
N
--
K
----
D
E
-----------
I
A
V
C
N
L
G
S
I
N
L
V
N
H
I
V
D
G
----
K
--------------------
L
------
D
T
A
K
L
E
----
K
T
V
K
T
A
V
R
M
L
D
N
V
I
D
I
NY
Y
S
V
P
Q
A
Q
N
S
N
F
K
H
R
P
V
--
G
--
L
G
I
M
G
---------
F
Q
D
A
L
Y
L
Q
H
IPYGS
D
-
A
A
I
A
F
A
D
Q
S
M
E
A
I
S
Y
Y
A
I
Q
A
-----------------------------------------------------------
S
-------------------------------------
C
D
-
L
------
A
D
E
R
G
A
Y
Q
T
F
QGSLWSQGIL
P
I
D
S
E
K
K
L
I
E
E
R
G
A
K
--------------------------------------------
Y
-----
I
E
V
D
--
L
S
E
T
--
L
---
D
W
----------
A
P
L
R
E
R
V
Q
K
GIR
N
S
-----
N
I
M
----
A
----
I
A
P
T
A
T
I
------------
A
N
--------
I
T
-
G
V
S
Q
S
-
I
-
E
P
T
------
Y
Q
N
L
Y
V
K
S
-
N
L
S
G
E
F
T
V
I
--
N
P
Y
L
-
V
---
R
D
----
L
K
A
R
G
L
W
D
P
V
M
V
N
-
D
L
K
Y
Y
D
G
S
V
Q
Q
I
E
R
I
P
Q
D
L
K
D
L
Y
A
T
A
F
E
V
E
T
R
W
I
V
--
E
A
A
S
R
R
Q
K
W
I
D
Q
A
Q
S
L
N
L
Y
I
A
G
------
A
S
G
K
K
L
D
V
T
Y
R
M
A
W
F
R
G
LK
T
T
Y
Y
L
R
A
L
A
A
T
-
29
HHSearch
33.95
12%
3
- C3 -
-
2YAJ
1
HPDL_CLOSL
C:
[313-896]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
I
A
H
K
K
P
A
N
F
W
E
A
I
Q
M
-
T
L
C
C
H
F
G
V
V
N
E
D
-
P
Q
S
G
L
S
I
G
R
L
G
Q
V
L
Q
P
F
Y
E
K
D
V
E
D
G
------------------
I
M
----------------------------
T
D
E
E
V
I
E
L
L
E
L
Y
R
I
K
--
I
T
C
I
E
C
F
A
S
A
G
V
S
G
GV
L
S
G
-
N
T
------
F
N
N
L
S
L
G
G
Q
N
Y
DGL
S
A
V
T
P
L
E
Y
L
I
----------------
V
E
A
G
M
R
--------------------------------
N
Q
T
P
Q
P
T
L
S
V
L
Y
--
D
E
K
T
P
--------------------------------
E
D
F
L
M
K
A
A
S
C
T
K
L
G
L
-
G
-------------------------------
Y
P
A
W
M
N
N
Q
T
------------------
G
M
N
F
M
M
R
N
YGPE
G
MD
L
H
D
A
R
A
--
W
C
--
L
G
G
C
L
E
S
A
P
-
G
C
F
L
P
L
E
Y
N
G
------
K
V
T
M
I
P
G
--
G
A
S
PT
C
G
-----------
T
G
V
---
H
F
I
G
M
P
K
V
L
E
L
V
----
L
T
NGLDKRTGKQVYPPHNKKL
D
------
S
Y
E
T
M
V
----
N
Q
W
K
E
Y
M
E
L
T
T
D
V
V
N
---
R
C
N
N
I
Q
M
D
I
W
R
K
Y
N
M
P
A
V
N
--
S
L
L
K
P
D
--
C
F
K
K
G
K
H
---
I
G
T
M
G
AR---
Y
N
S
C
I
N
F
E
S
C
G
T
I
T
F
V
N
S
L
S
S
I
K
K
N
VFDDSKFT
I
E
E
M
T
D
A
M
L
N
NFGFKTAYETEVFSPD
F
R
E
S
T
DKSTKY
E
K
I
F
A
A
C
V
N
AP
K
-------------------------------------
Y
G
N
A
------
D
K
Y
A
D
E
I
F
K
A
----------
Y
H
Y
Y
I
Y
D
M
T
H
K
F
R
S
Y
--------------------------------------------
Y
G
K
P
L
Y
L
C
Q
I
--
S
V
S
T
H
G
P
---
Q
G
F
V
--------
T
L
A
T
A
D
G
R
L
---
A
G
-----
T
---------------
T
-
Y
------------
S
D
--------
G
S
V
S
A
A
A
G
-
T
D
K
N
G
I
Y
A
I
F
E
S
A
T
V
Y
D
-
H
-
S
M
H
Q
N
A
Q
M
N
L
K
L
H
P
T
A
V
KG
I
N
G
----
T
R
K
L
L
D
L
V
R
A
Y
M
R
K
G
G
F
H
V
-
Q
F
N
V
V
D
S
----------
K
T
L
R
----
D
A
Q
L
T
P
E
K
Y
R
------
E
L
M
V
R
V
A
G
F
T
Q
Y
W
C
--
E
I
G
K
P
I
Q
D
E
V
I
Y
R
T
E
Y
D
----------------
18
HHSearch
33.81
15%
18
- C3 -
-
1R9D
1
?
A:
[250-786]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
V
S
G
E
G
A
K
S
F
Y
E
A
C
Q
L
-
F
W
F
I
H
A
I
I
N
I
E
S
N
G
H
-
S
I
S
P
A
R
F
D
Q
Y
M
Y
P
Y
Y
E
N
D
K
---------------------
N
I
----------------------------
T
D
K
F
A
Q
E
L
I
D
C
I
W
I
K
--
L
N
D
I
N
K
V
R
D
E
I
S
T
K
--
H
F
G
G
Y
P
M-----
Y
Q
N
L
I
V
G
G
Q
N
S
EGK
D
A
T
N
K
V
S
Y
M
A
----------------
L
E
A
A
V
H
V
-------------------------------
K
L
P
Q
-
P
S
L
S
V
R
I
--
W
N
K
T
P
--------------------------------
D
E
F
L
L
R
A
A
E
L
T
R
E
-
G
L
G
-------------------------------
L
P
A
Y
Y
N
D
E
V
------------------
I
I
P
A
--
L
V
S
R
--
G
LT
L
E
D
A
R
D
--
Y
G
--
I
I
G
C
---------------
V
------
E
P
-
Q
K
P
G
KT
E
----
G
W
-----------
H
D
S
---
A
F
F
N
L
A
R
I
V
E
L
T
----
I
N
SGFDKNKQIGPKT------
Q
NFEEMK
S
F
D
E
F
M
K
A
Y
K
A
Q
M
E
Y
F
V
K
H
M
C
C
A
D
N
---
C
I
D
I
A
H
A
E
R
A
P
--
L
P
F
L
S
S
M
V
D
N
C
I
G
K
GK
S
L
Q
D
G
G
-----
A
E
-------
Y
-
N
F
S
G
P
Q
G
V
G
V
A
N
I
G
D
S
L
V
A
V
-----------------------------------------------------------
K
K
IVFDENKIT
P
S
E
L
K
K
T
L
N
N
DFKNS
E
E
I
Q
A
L
L
K
N
APK
F
G
N
D
------
I
D
E
V
D
N
L
A
R
E
----------
G
A
L
V
Y
C
R
E
V
N
K
Y
T
N
P
--------------------------------------------
R
G
----
G
N
F
Q
--
P
G
L
Y
--
P
SSI
N
V
----------
Y
F
G
S
-
L
T
G
A
---
T
P
-----
D
G
R
---------
K
S
G
Q
P
L
A
------------
D
G
---------
V
-
S
P
S
R
G
C
D
-
V
S
G
P
T
A
A
C
N
S
V
S
K
L
D
-
H
F
I
A
S
N
G
T
L
F
N
Q
K
F
H
P
S
-
A
---
L
K
G
D
N
G
L
M
N
L
S
S
L
I
R
S
Y
F
D
Q
K
G
F
H
V
-
Q
F
N
V
I
D
-----------
K
K
I
L
---
L
A
A
Q
K
N
P
E
K
Y
-
Q
-----
D
L
I
V
R
V
A
G
Y
S
A
-
Q
F
I
-
S
L
D
K
S
I
Q
N
D
I
I
A
R
T
E
H
V
----------------
36
HHSearch
33.47
12%
-42
- C3 -
-
1XJE
1
?
A:
[240-630]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
N
L
S
V
G
F
P
M
D
---
K
------
K
E
I
----------------
L
K
L
Y
E
E
D
G
E
---------------------------
L
-
E
L
S
H
-
P
R
S
T
--
I
--
R
K
K
V
-------------------------------
K
I
R
E
L
F
R
K
I
A
T
N
A
W
K
-
S
-
G
-------------------------------
D
P
G
L
A
F
L
G
E
------------------
M
N
K
Y
--
Y
-----
P
-----------
L
--
Y
P
H
R
K
I
N
S
T
N
P
C
-------
G
------
E
I
-
G
L
S
D
--
Y
----
E
A
-----------
C
N
L
---
G
S
I
D
V
A
K
F
Y
N
N
G
----
F
--------------------
V
------
D
----
L
----
E
A
L
Q
E
L
V
Q
I
A
V
R
F
L
D
---
N
V
I
D
V
------
N
V
F
P
I
D
K
I
--
T
---------------
K
A
V
K
E
S
--------
R
R
L
G
L
G
I
M
G
F
A
D
L
L
Y
K
L
-
E
I
-----------------------------------------------------------
P
-------------------------------------
Y
--
N
------
S
Q
E
A
R
D
F
A
A
N
----------
L
M
A
F
I
A
L
H
A
H
R
T
S
Y
E
L
G
K
E
KGNFPLLEISRYRTEDNFVPFAMGMSNY
D
D
E
I
R
E
V
M
K
M
T
K
E
F
R
R
N
V
A
L
L
T
I
A
P
T
G
S
--
I
---
S
N
I
A
DTSSGLEP
N
F
L
L
A
Y
T
R
F
V
T-
K
E
DGTKE
P
L
L
Y
V
N
Q
V
L
R
E
K
L
N
P
E
I
L
K
R
I
E
K
E
L
I
E
K
GSL
K
D
IPDVP
E
K
I
K
K
-
V
F
V
V
A
-
L
-
D
I
D
P
M
D
H
L
L
M
Q
D
A
F
Q
-
R
-
Y
V
D
N
N
I
S
K
T
I
N
M
P
Q
S
-
A
----
T
----
V
D
D
V
L
N
V
Y
L
E
A
L
R
T
N
V
R
G
I
-
T
V
Y
R
D
-------------------------------------------------------------------------------------