@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0234: (2017-12-18 )
MRIFASPSRYIQGENALFENAKSILDLGNYPILLCDQLVYDIVGKRFEDYLHRYGFHIVLALFNGEASDNEINRVVALAEKENCDSIIGLGGGKTIDSAKAIADLIEKPVIIAPTIASTDAPVSALSVIYTDEGAFDHYLFYSKNPDLVLVDTKVISQAPKRLLASGIADGLATWVEARAVMQANGKTMLGQQQTLAGVAIAKKCEETLFADGLQAMAACEAKVVTPALENIVEANTLLSGLGFESGGLAAAHAIHNGFTALTGDIHHLTHGEKVAYGTLVQLLLENRPKEELDKYIEFYKKIGMPTTLKEMHLDQVGYDDLIKVGKQATMEGETIHQMPFKISPSDVAQAIIAVDAYVNSK
Atome Classification :
(20 SA)
--.........10........20.......-.30-........-40-.----.......50.......-.60........70........80........90........100...------------------....110.......120.......130.......140--.......150.......160.......170.......180.......190.........200........210..----.--------...--------.220.......230.......240.......250.......260.......270.....--..280...--------------...---------.290.......300.......310.......320.-......330.---......340.......350.......360---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MRIFASPSRYIQG
E
N
A
L
F
E
N
A
K
S
I
L
DLG-N
Y
P
-
I
L
L
C
D
Q
L
V
-
Y
D
-
I
----
V
G
K
R
F
E
D
Y
L
H
RY
G
F
H
I
-
V
L
A
L
FNGEASDN
E
I
N
R
V
V
A
LAEKENCD
S
I
I
GLGGGKTI
D
S
A
K
A
I
A
D
L
------------------
I
EK
P
V
I
I
APTIASTDAPV
S
A
L
S
V
I
YTDEGAF
D
H
Y
L
F
Y--SKNP
D
L
V
L
V
D
T
K
V
I
S
Q
A
P
K
R
L
L
A
S
G
I
A
D
G
L
A
T
W
V
E
A
R
A
V
M
QANG
K
T
ML--GQQ
Q
T
L
A
G
V
A
I
-
A
K
K
C
E
E
T
L
F
A
D
G
L
----
Q
--------
A
M
A
--------ACEAKVV
T
P
A
L
E
N
I
V
E
A
N
T
L
L
S
GLGFESG
G
L
A
A
A
H
A
I
HN
G
F
T
A
LTGDIHHLTHGEK
V
A
Y
--
G
T
L
V
Q
L
L
L
--------------ENR---------
P
K
E
E
L
D
K
Y
I
E
F
Y
K
KIGMP
T
T
L
K
E
M
H
L
D
QVG
Y
D
D
L
I
-
K
V
G
K
QATMEG---E
T
I
HQMPFKI
S
P
S
D
V
A
Q
A
I
I
A
V
D
A
YVNSK---
3
PsiBlast_PDB
96.89
55%
-96
- C2 -
-
1JQ5
1
GLDA_GEOSE
A:
[5-363]
---
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
-
N
K
T
-
V
V
I
A
D
E
I
V
-
W
K
-
I
----
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
-
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
V
F
E
S
Y
R
F
Y
--
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
G
G
K
T
M
A
--
G
G
I
P
T
I
A
A
E
A
I
-
A
E
K
C
E
Q
T
L
F
K
Y
G
K
----
L
--------
A
Y
E
--------
S
V
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
H
H
L
T
H
G
E
K
V
A
F
--
G
T
L
V
Q
L
A
L
--------------
E
E
H
---------
S
Q
Q
E
I
E
R
Y
I
E
L
Y
L
C
L
D
L
P
V
T
L
E
D
I
K
L
K
D
A
S
R
E
D
I
L
-
K
V
A
K
A
A
T
A
E
G
---
E
T
I
H
N
-
A
F
N
V
T
A
D
D
V
A
D
A
I
F
A
A
D
Q
Y
A
K
A
----
27
HHSearch
96.51
55%
-97
- C2 -
-
1JQ5
1
GLDA_GEOSE
A:
[5-362]
---
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
-
N
K
T
-
V
V
I
A
D
E
I
V
-
W
K
-
I
----
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
-
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
V
F
E
S
Y
R
F
Y
--
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
G
G
K
T
M
A
--
G
G
I
P
T
I
A
A
E
A
I
-
A
E
K
C
E
Q
T
L
F
K
Y
G
K
----
L
--------
A
Y
E
--------
S
V
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
H
H
L
T
H
G
E
K
V
A
F
--
G
T
L
V
Q
L
A
L
--------------
E
E
H
---------
S
Q
Q
E
I
E
R
Y
I
E
L
Y
L
C
L
D
L
P
V
T
L
E
D
I
K
L
K
D
A
S
R
E
D
I
L
-
K
V
A
K
A
A
T
A
E
G
----
E
T
I
H
N
A
F
N
V
T
A
D
D
V
A
D
A
I
F
A
A
D
Q
Y
A
K
-----
1
PsiBlast_PDB
96.10
55%
-102
- C2 -
-
1JPU
-
GLDA_GEOSE
A:
[5-363]
---
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
-
N
K
T
-
V
V
I
A
D
E
I
V
-
W
K
-
I
----
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
-
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
-----
G
V
F
E
S
Y
R
F
Y
--
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
G
G
K
T
M
A
--
G
G
I
P
T
I
A
A
E
A
I
-
A
E
K
C
E
Q
T
L
F
K
Y
G
K
----
L
--------
A
Y
E
--------
S
V
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
H
H
L
T
H
G
E
K
V
A
F
--
G
T
L
V
Q
L
A
L
--------------
E
E
H
---------
S
Q
Q
E
I
E
R
Y
I
E
L
Y
L
C
L
D
L
P
V
T
L
E
D
I
K
L
K
D
A
S
R
E
D
I
L
-
K
V
A
K
A
A
T
A
E
G
---
E
T
I
H
N
-
A
F
N
V
T
A
D
D
V
A
D
A
I
F
A
A
D
Q
Y
A
K
A
----
2
PsiBlast_PDB
94.71
55%
-104
- C2 -
-
1JQA
1
GLDA_GEOSE
A:
[5-363]
---
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
-
N
K
T
-
V
V
I
A
D
E
I
V
-
W
K
-
I
----
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
-
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
----
V
F
E
S
Y
R
F
Y
--
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
G
G
K
T
M
A
--
G
G
I
P
T
I
A
A
E
A
I
-
A
E
K
C
E
Q
T
L
F
K
Y
G
K
----
L
--------
A
Y
E
--------
S
V
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
H
H
L
T
H
G
E
K
V
A
F
--
G
T
L
V
Q
L
A
L
--------------
E
E
H
---------
S
Q
Q
E
I
E
R
Y
I
E
L
Y
L
C
L
D
L
P
V
T
L
E
D
I
K
L
K
D
A
S
R
E
D
I
L
-
K
V
A
K
A
A
T
A
E
G
---
E
T
I
H
N
-
A
F
N
V
T
A
D
D
V
A
D
A
I
F
A
A
D
Q
Y
A
K
A
----
4
PsiBlast_PDB
93.11
47%
-114
- C2 -
-
4MCA
2
?
A:
[2-356]
--
L
R
I
I
Q
S
P
G
K
Y
I
Q
G
A
N
A
L
A
A
V
G
Q
Y
A
K
S
L
A
-
D
H
Y
-
L
V
I
A
D
D
F
V
-
M
K
-
L
----
A
G
D
T
L
M
G
S
L
Q
Q
H
G
V
K
H
-
H
A
A
L
F
N
G
E
C
C
H
K
E
I
D
R
L
G
R
E
L
K
A
H
G
C
R
G
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
I
A
H
Y
------------------
Q
Q
L
P
V
V
L
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
Q
G
E
F
A
E
Y
L
I
Y
--
P
R
N
P
D
M
V
V
M
D
V
A
I
I
A
K
A
P
V
R
L
L
V
A
G
M
G
D
A
L
S
T
Y
F
E
A
Q
A
C
F
D
A
Q
A
T
S
M
A
--
G
G
K
S
T
L
A
A
L
S
L
-
A
R
L
C
Y
D
T
L
L
A
E
G
V
----
K
--------
A
K
L
--------
A
V
E
A
G
V
V
T
E
A
V
E
R
I
I
E
A
N
T
Y
L
S
G
I
G
F
E
S
S
G
L
A
A
A
H
A
I
H
N
G
F
T
V
L
E
-
E
C
H
H
L
Y
H
G
E
K
V
A
F
--
G
T
L
A
Q
L
V
L
--------------
Q
N
S
---------
P
M
A
Q
I
E
T
V
L
A
F
C
H
R
I
G
L
P
I
T
L
A
E
M
G
V
S
G
D
A
V
E
K
I
M
-
A
V
A
Q
A
S
C
A
A
G
---
E
T
I
H
N
M
P
F
K
V
T
P
A
G
V
Q
A
A
I
L
T
A
D
---------
21
PsiBlast_CBE
93.01
47%
-116
- C2 -
-
4MCA
2
?
B:
[2-356]
--
L
R
I
I
Q
S
P
G
K
Y
I
Q
G
A
N
A
L
A
A
V
G
Q
Y
A
K
S
L
A
-
D
H
Y
-
L
V
I
A
D
D
F
V
-
M
K
-
L
----
A
G
D
T
L
M
G
S
L
Q
Q
H
G
V
K
H
-
H
A
A
L
F
N
G
--
C
H
K
E
I
D
R
L
G
R
E
L
K
A
H
G
C
R
G
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
I
A
H
Y
------------------
Q
Q
L
P
V
V
L
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
Q
G
E
F
A
E
Y
L
I
Y
--
P
R
N
P
D
M
V
V
M
D
V
A
I
I
A
K
A
P
V
R
L
L
V
A
G
M
G
D
A
L
S
T
Y
F
E
A
Q
A
C
F
D
A
Q
A
T
S
M
A
--
G
G
K
S
T
L
A
A
L
S
L
-
A
R
L
C
Y
D
T
L
L
A
E
G
V
----
K
--------
A
K
L
--------
A
V
E
A
G
V
V
T
E
A
V
E
R
I
I
E
A
N
T
Y
L
S
G
I
G
F
E
S
S
G
L
A
A
A
H
A
I
H
N
G
F
T
V
L
E
-
E
C
H
H
L
Y
H
G
E
K
V
A
F
--
G
T
L
A
Q
L
V
L
--------------
Q
N
S
---------
P
M
A
Q
I
E
T
V
L
A
F
C
H
R
I
G
L
P
I
T
L
A
E
M
G
V
S
G
D
A
V
E
K
I
M
-
A
V
A
Q
A
S
C
A
A
G
---
E
T
I
H
N
M
P
F
K
V
T
P
A
G
V
Q
A
A
I
L
T
A
D
---------
5
PsiBlast_PDB
90.90
48%
-96
- C2 -
-
5XN8
1
?
A:
[2-356]
--
L
K
V
I
Q
S
P
G
K
Y
L
Q
G
P
D
A
S
T
L
F
G
A
Y
A
K
N
L
A
-
E
S
F
-
F
V
I
A
D
D
F
V
-
M
K
-
L
----
A
G
D
K
V
L
N
G
L
H
S
H
D
I
S
L
-
H
A
E
R
F
N
G
E
C
S
H
V
E
I
R
R
L
I
A
I
L
K
Q
H
G
C
R
G
V
V
G
V
G
G
G
K
T
L
D
T
A
K
A
I
G
Y
Y
------------------
Q
K
L
P
V
V
V
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
A
G
E
F
E
E
Y
L
I
Y
--
P
K
N
P
D
M
V
V
M
D
T
A
I
I
A
K
A
P
V
R
L
L
V
S
G
M
G
D
A
L
S
T
W
F
E
A
K
A
C
Y
D
A
R
A
T
S
M
A
--
G
G
Q
S
T
E
A
A
L
S
L
-
A
R
L
C
Y
D
T
L
L
A
E
G
E
----
K
--------
A
R
L
--------
A
A
Q
A
G
V
V
T
D
A
L
E
R
I
I
E
A
N
T
Y
L
S
G
I
G
F
E
S
S
G
L
A
A
A
H
A
I
H
N
G
F
T
I
L
E
-
E
C
H
H
L
Y
H
G
E
K
V
A
F
--
G
T
L
A
Q
L
V
L
--------------
Q
N
S
---------
P
M
E
E
I
E
T
V
L
G
F
C
E
K
V
G
L
P
V
T
L
A
Q
M
G
V
K
E
-
G
I
D
D
K
I
A
A
V
A
K
A
T
C
A
E
G
---
E
T
I
H
N
M
P
F
A
V
T
P
E
Q
V
H
A
A
I
L
T
A
D
---------
23
PsiBlast_CBE
89.19
48%
-95
- C2 -
-
5XN8
1
?
C:
[2-356]
--
L
K
V
I
Q
S
P
G
K
Y
L
Q
G
P
D
A
-
T
L
F
G
A
Y
A
K
N
L
A
-
E
S
F
-
F
V
I
A
D
D
F
V
-
M
K
-
L
----
A
G
D
K
V
L
N
G
L
H
S
H
D
I
S
L
-
H
A
E
R
F
N
G
E
C
S
H
V
E
I
R
R
L
I
A
I
L
K
Q
H
G
C
R
G
V
V
G
V
G
G
G
K
T
L
D
T
A
K
A
I
G
Y
Y
------------------
Q
K
L
P
V
V
V
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
A
G
E
F
E
E
Y
L
I
Y
--
P
K
N
P
D
M
V
V
M
D
T
A
I
I
A
K
A
P
V
R
L
L
V
S
G
M
G
D
A
L
S
T
W
F
E
A
K
A
C
Y
D
A
R
A
T
S
M
A
--
G
G
Q
S
T
E
A
A
L
S
L
-
A
R
L
C
Y
D
T
L
L
A
E
G
E
----
K
--------
A
R
L
--------
A
A
Q
A
G
V
V
T
D
A
L
E
R
I
I
E
A
N
T
Y
L
S
G
I
G
F
E
S
S
G
L
A
A
A
H
A
I
H
N
G
F
T
I
L
E
-
E
C
H
H
L
Y
H
G
E
K
V
A
F
--
G
T
L
A
Q
L
V
L
--------------
Q
N
S
---------
P
M
E
E
I
E
T
V
L
G
F
C
E
K
V
G
L
P
V
T
L
A
Q
M
G
V
K
E
-
G
I
D
D
K
I
A
A
V
A
K
A
T
C
A
E
G
---
E
T
I
H
N
M
P
F
A
V
T
P
E
Q
V
H
A
A
I
L
T
A
D
---------
50
Fugue
87.78
55%
-5
- C2 -
-
1JQ5
1
GLDA_GEOSE
A:
[2-367]
A
A
E
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
-
N
K
T
-
V
V
I
A
D
E
I
V
-
W
K
--
I
---
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
-
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
V
F
E
S
Y
R
F
Y
--
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
G
G
K
T
M
A
--
G
G
I
P
T
I
A
A
E
A
I
-
A
E
K
C
E
Q
T
L
F
K
Y
G
K
----
L
--------
A
Y
E
--------
S
V
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
H
H
L
T
H
G
E
K
V
A
F
--
G
T
L
V
Q
L
A
L
--------------
E
E
H
---------
S
Q
Q
E
I
E
R
Y
I
E
L
Y
L
C
L
D
L
P
V
T
L
E
D
I
K
L
K
D
A
S
R
E
D
I
L
-
K
V
A
K
A
A
T
A
E
G
---
E
T
I
H
N
A
-
F
N
V
T
A
D
D
V
A
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
E
K
28
HHSearch
87.47
46%
-89
- C2 -
-
4MCA
2
?
B:
[2-360]
--
L
R
I
I
Q
S
P
G
K
Y
I
Q
G
A
N
A
L
A
A
V
G
Q
Y
A
K
S
L
A
-
D
H
Y
-
L
V
I
A
D
D
F
V
-
M
K
-
L
----
A
G
D
T
L
M
G
S
L
Q
Q
H
G
V
K
H
-
H
A
A
L
F
N
G
--
C
H
K
E
I
D
R
L
G
R
E
L
K
A
H
G
C
R
G
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
I
A
H
Y
------------------
Q
Q
L
P
V
V
L
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
Q
G
E
F
A
E
Y
L
I
Y
--
P
R
N
P
D
M
V
V
M
D
V
A
I
I
A
K
A
P
V
R
L
L
V
A
G
M
G
D
A
L
S
T
Y
F
E
A
Q
A
C
F
D
A
Q
A
T
S
M
------
A
G
G
K
S
T
L
A
-
A
L
S
L
A
R
L
C
Y
D
T
L
L
----
A
E
G
V
K
----
A
K
L
--------
A
V
E
A
G
V
V
T
E
A
V
E
R
I
I
E
A
N
T
Y
L
S
G
I
G
F
E
S
S
G
L
A
A
A
H
A
I
H
N
G
F
T
V
L
E
-
E
C
H
H
L
Y
H
G
E
K
V
A
F
--
G
T
L
A
Q
L
V
L
--------------
Q
N
S
---------
P
M
A
Q
I
E
T
V
L
A
F
C
H
R
I
G
L
P
I
T
L
A
E
M
G
V
S
---
G
D
A
V
E
-
K
I
M
A
V
A
Q
A
S
C
AAG
E
T
I
H
N
M
P
F
K
V
T
P
A
G
V
Q
A
A
I
L
T
A
D
R
L
G
S
-----
49
Fugue
85.61
55%
13
- C2 -
-
1JQ5
1
GLDA_GEOSE
A:
[2-367]
A
A
E
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
-
N
K
T
-
V
V
I
A
D
E
I
V
-
W
K
-
I
----
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
-
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
V
F
E
S
Y
R
F
Y
--
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
G
G
K
T
M
A
--
G
G
I
P
T
I
A
A
E
A
I
-
A
E
K
C
E
Q
T
L
F
K
Y
G
K
----
L
--------
A
Y
E
--------
S
V
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
H
H
L
T
H
G
E
K
V
A
F
--
G
T
L
V
Q
L
A
L
--------------
E
E
H
---------
S
Q
Q
E
I
E
R
Y
I
E
L
Y
L
C
L
D
L
P
V
T
L
E
D
I
K
L
K
D
A
S
R
E
D
I
L
-
K
V
A
K
A
A
T
A
E
G
---
E
T
I
H
N
-
A
F
N
V
T
A
D
D
V
A
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
E
K
25
PsiBlast_CBE
81.51
45%
-20
- C2 -
-
1TA9
1
GLD1_SCHPO
B:
[64-420]
---
R
I
F
T
S
P
Q
K
Y
V
Q
G
R
H
A
F
T
R
S
Y
M
Y
V
K
K
W
A
-
T
K
S
A
V
V
L
A
D
Q
N
V
-
W
N
-
I
----
C
A
N
K
I
V
D
S
L
S
Q
N
G
M
T
V
-
T
K
L
V
F
G
G
E
A
S
L
V
E
L
D
K
L
R
K
Q
C
-
P
D
D
T
Q
V
I
I
G
V
G
G
G
K
T
M
D
S
A
K
Y
I
A
H
S
------------------
M
N
L
P
S
I
I
C
P
T
T
A
S
S
D
A
A
T
S
S
L
S
V
I
Y
T
P
D
G
Q
F
Q
K
Y
S
F
Y
--
P
L
N
P
N
L
I
F
I
D
T
D
V
I
V
R
A
P
V
R
F
L
I
S
G
I
G
D
A
L
S
T
W
V
E
T
E
S
V
I
R
S
N
S
T
S
F
A
--
G
G
V
A
S
I
A
G
R
Y
I
-
A
R
A
C
K
D
T
L
E
K
Y
A
L
----
S
--------
A
I
L
--------
S
N
T
R
G
V
C
T
E
A
F
E
N
V
V
E
A
N
T
L
M
S
G
L
G
F
E
N
G
G
L
A
A
A
H
A
I
H
N
G
M
T
A
I
H
G
P
V
H
R
L
M
H
G
E
K
V
A
Y
--
G
T
L
V
Q
V
V
L
--------------
E
D
W
---------
P
L
E
D
F
N
N
L
A
S
F
M
A
K
C
H
L
P
I
T
L
E
E
L
G
I
P
N
V
T
D
E
E
L
L
-
M
V
G
R
A
T
L
R
P
D
---
E
S
I
H
N
M
S
K
K
F
N
P
S
Q
I
A
D
A
I
K
A
V
D
S
Y
-------
7
PsiBlast_PDB
80.92
45%
-21
- C2 -
-
1TA9
3
GLD1_SCHPO
A:
[64-420]
---
R
I
F
T
S
P
Q
K
Y
V
Q
G
R
H
A
F
T
R
S
Y
M
Y
V
K
K
W
A
-
T
K
S
A
V
V
L
A
D
Q
N
V
-
W
N
-
I
----
C
A
N
K
I
V
D
S
L
S
Q
N
G
M
T
V
-
T
K
L
V
F
G
G
E
A
S
L
V
E
L
D
K
L
R
K
Q
C
-
P
D
D
T
Q
V
I
I
G
V
G
G
G
K
T
M
D
S
A
K
Y
I
A
H
S
------------------
M
N
L
P
S
I
I
C
P
T
T
A
S
S
D
A
A
T
S
S
L
S
V
I
Y
----
Q
F
Q
K
Y
S
F
Y
--
P
L
N
P
N
L
I
F
I
D
T
D
V
I
V
R
A
P
V
R
F
L
I
S
G
I
G
D
A
L
S
T
W
V
E
T
E
S
V
I
R
S
N
S
T
S
F
A
--
G
G
V
A
S
I
A
G
R
Y
I
-
A
R
A
C
K
D
T
L
E
K
Y
A
L
----
S
--------
A
I
L
--------
S
N
T
R
G
V
C
T
E
A
F
E
N
V
V
E
A
N
T
L
M
S
G
L
G
F
E
N
G
G
L
A
A
A
H
A
I
H
N
G
M
T
A
I
H
G
P
V
H
R
L
M
H
G
E
K
V
A
Y
--
G
T
L
V
Q
V
V
L
--------------
E
D
W
---------
P
L
E
D
F
N
N
L
A
S
F
M
A
K
C
H
L
P
I
T
L
E
E
L
G
I
P
N
V
T
D
E
E
L
L
-
M
V
G
R
A
T
L
R
P
D
---
E
S
I
H
N
M
S
K
K
F
N
P
S
Q
I
A
D
A
I
K
A
V
D
S
Y
-------
30
HHSearch
78.72
44%
-12
- C2 -
-
1TA9
1
GLD1_SCHPO
B:
[64-423]
---
R
I
F
T
S
P
Q
K
Y
V
Q
G
R
H
A
F
T
R
S
Y
M
Y
V
K
K
W
A
T
K
S
A
-
V
V
L
A
D
Q
N
V
-
W
N
-
I
----
C
A
N
K
I
V
D
S
L
S
Q
N
G
M
T
V
-
T
K
L
V
F
G
G
E
A
S
L
V
E
L
D
K
L
R
K
Q
C
P
-
D
D
T
Q
V
I
I
G
V
G
G
G
K
T
M
D
S
A
K
Y
I
A
H
S
------------------
M
N
L
P
S
I
I
C
P
T
T
A
S
S
D
A
A
T
S
S
L
S
V
I
Y
T
P
D
G
Q
F
Q
K
Y
S
F
Y
--
P
L
N
P
N
L
I
F
I
D
T
D
V
I
V
R
A
P
V
R
F
L
I
S
G
I
G
D
A
L
S
T
W
V
E
T
E
S
V
I
R
S
N
----------
S
T
S
F
A
G
G
V
-
A
S
I
A
G
R
Y
I
A
R
A
C
K
----
D
--------
T
L
E
K
Y
A
L
S
A
I
L
S
N
T
R
G
V
C
T
E
A
F
E
N
V
V
E
A
N
T
L
M
S
G
L
G
F
E
N
G
G
L
A
A
A
H
A
I
H
N
G
M
T
A
I
H
G
P
V
H
R
L
M
H
G
E
K
V
A
Y
--
G
T
L
V
Q
V
V
L
--------------
E
D
W
---------
P
L
E
D
F
N
N
L
A
S
F
M
A
K
C
H
L
P
I
T
L
E
E
L
G
I
P
N
V
T
D
E
E
L
L
-
M
V
G
R
A
T
L
R
P
D
---
E
S
I
H
N
M
S
K
K
F
N
P
S
Q
I
A
D
A
I
K
A
V
D
S
Y
S
Q
K
----
8
PsiBlast_PDB
77.82
40%
-30
- C2 -
-
3UHJ
1
?
A:
[26-385]
---
R
A
F
G
G
P
N
K
Y
I
Q
R
A
G
E
I
D
K
L
A
A
Y
L
A
P
L
G
-
K
R
A
-
L
V
L
I
D
R
V
L
-
F
D
-
A
L
S
E
R
I
------
S
L
D
-----
I
-
R
F
E
R
F
G
G
E
C
C
T
S
E
I
E
R
V
R
K
V
A
I
E
H
G
S
D
I
L
V
G
V
G
G
G
K
T
A
D
T
A
K
I
V
A
I
D
------------------
T
G
A
R
I
V
I
A
P
T
I
A
S
T
D
A
P
C
S
A
I
A
V
R
Y
T
E
H
G
V
Y
E
E
A
L
R
L
--
P
R
N
P
D
A
V
V
V
D
S
A
L
V
A
A
A
P
A
R
F
L
V
A
G
I
G
D
A
L
S
T
W
F
E
A
R
S
N
I
E
S
R
T
D
N
Y
V
AG
G
F
P
A
T
E
A
G
M
A
I
-
A
R
H
C
Q
D
V
L
T
R
D
A
V
----
K
--------
A
K
I
--------
A
V
E
A
G
L
L
T
P
A
V
E
N
I
I
E
A
N
T
L
L
S
G
L
G
F
E
N
C
G
C
S
A
A
H
G
I
H
D
G
L
T
V
L
E
-
E
V
H
G
Y
F
H
G
E
K
V
A
F
--
G
T
L
C
L
L
M
L
--------------
E
N
R
---------
D
R
A
E
I
E
A
M
I
R
F
C
R
S
V
G
L
P
T
K
L
A
D
L
G
I
V
D
D
V
P
A
K
I
G
-
R
V
A
E
A
A
C
R
P
G
---
N
I
I
Y
A
T
P
V
T
I
T
V
P
A
V
R
D
A
I
L
A
L
D
A
F
S
R
S
----
6
PsiBlast_PDB
77.61
47%
-15
- C2 -
-
1KQ3
1
GLDA_THEMA
A:
[20-368]
--------
P
G
R
Y
V
Q
G
A
G
A
I
N
I
L
E
E
E
L
S
R
F
G
-
E
R
A
-
F
V
V
I
D
D
F
V
D
K
N
-
V
----
L
G
E
N
F
F
S
S
F
T
K
--
V
R
V
-
N
K
Q
I
F
G
G
E
C
S
D
E
E
I
E
R
L
S
G
L
V
E
E
E
T
-
D
V
V
V
G
I
G
G
G
K
T
L
D
T
A
K
A
V
A
Y
K
------------------
L
K
K
P
V
V
I
V
P
T
I
A
S
T
D
A
P
C
S
A
L
S
V
I
Y
T
P
N
G
E
F
K
R
Y
L
F
L
--
P
R
N
P
D
V
V
L
V
D
T
E
I
V
A
K
A
P
A
R
F
L
V
A
G
M
G
D
A
L
A
T
W
F
E
A
E
S
C
K
Q
K
Y
A
P
N
M
T
--
G
R
L
G
S
M
T
A
Y
A
L
-
A
R
L
C
Y
E
T
L
L
E
Y
G
V
----
L
--------
A
K
R
--------
S
V
E
E
K
S
V
T
P
A
L
E
K
I
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
L
T
V
L
E
-
N
T
H
K
Y
L
H
G
E
K
V
A
I
--
G
V
L
A
S
L
F
L
--------------
T
D
K
---------
P
R
K
M
I
E
E
V
Y
S
F
C
E
E
V
G
L
P
T
T
L
A
E
I
G
L
D
G
V
S
D
E
D
L
M
-
K
V
A
E
K
A
C
D
K
N
---
E
T
I
H
N
E
P
Q
P
V
T
S
K
D
V
F
F
A
L
K
A
A
D
R
Y
-------
35
HHSearch
77.36
39%
-45
- C2 -
-
3UHJ
2
?
E:
[26-385]
---
R
A
F
G
G
P
N
K
Y
I
Q
R
A
G
E
I
D
K
L
A
A
Y
L
A
P
L
G
-
K
R
A
-
L
V
L
I
D
R
V
L
-
F
D
-
A
----
L
S
E
R
I
------
S
-
L
D
I
-
R
F
E
R
F
G
G
E
C
C
T
S
E
I
E
R
V
R
K
V
A
I
E
H
G
S
D
I
L
V
G
V
G
G
G
K
T
A
D
T
A
K
I
V
A
I
D
------------------
T
G
A
R
I
V
I
A
P
T
I
A
S
T
D
A
P
C
S
A
I
A
V
R
Y
T
E
H
G
V
-
Y
E
E
A
L
R
L-
P
R
N
P
D
A
V
V
V
D
S
A
L
V
A
A
A
P
A
R
F
L
V
A
G
I
G
D
A
L
S
T
W
F
E
A
R
S
N
I
E
S
R
T
---------
D
N
--
A
G
G
F
P
A
T
E
A
G
M
A
I
A
R
H
C
Q
----
D
VLTRDAVK
A
K
I
--------
A
V
E
A
G
L
L
T
P
A
V
E
N
I
I
E
A
N
T
L
L
S
G
L
G
F
E
N
C
G
C
S
A
A
H
G
I
H
D
G
L
T
V
L
E
-
E
V
H
G
Y
F
H
G
E
K
V
A
F
--
G
T
L
C
L
L
M
L
--------------
E
N
R
---------
D
R
A
E
I
E
A
M
I
R
F
C
R
S
V
G
L
P
T
K
L
A
D
L
G
I
V
D
D
V
P
A
K
I
G
-
R
V
A
E
A
A
C
R
P
G
---
N
I
I
Y
A
T
P
V
T
I
T
V
P
A
V
R
D
A
I
L
A
L
D
A
F
S
R
S
----
36
HHSearch
76.58
39%
-48
- C2 -
-
3UHJ
1
?
A:
[26-385]
---
R
A
F
G
G
P
N
K
Y
I
Q
R
A
G
E
I
D
K
L
A
A
Y
L
A
P
L
G
-
K
R
A
-
L
V
L
I
D
R
V
L
-
F
D
-
A
----
L
S
E
R
I
------
S
-
L
D
I
-
R
F
E
R
F
G
G
E
C
C
T
S
E
I
E
R
V
R
K
V
A
I
E
H
G
S
D
I
L
V
G
V
G
G
G
K
T
A
D
T
A
K
I
V
A
I
D
------------------
T
G
A
R
I
V
I
A
P
T
I
A
S
T
D
A
P
C
S
A
I
A
V
R
Y
T
E
H
G
V
-
Y
E
E
A
L
R
L
-
P
R
N
P
D
A
V
V
V
D
S
A
L
V
A
A
A
P
A
R
F
L
V
A
G
I
G
D
A
L
S
T
W
F
E
A
R
S
N
I
E
S
R
T
---------
D
N
Y
V
A
G
G
F
P
A
T
E
A
G
M
A
I
A
R
H
C
Q
----
D
V
L
T
R
D
A
V
K
A
K
I
--------
A
V
E
A
G
L
L
T
P
A
V
E
N
I
I
E
A
N
T
L
L
S
G
L
G
F
E
N
C
G
C
S
A
A
H
G
I
H
D
G
L
T
V
L
E
-
E
V
H
G
Y
F
H
G
E
K
V
A
F
--
G
T
L
C
L
L
M
L
--------------
E
N
R
---------
D
R
A
E
I
E
A
M
I
R
F
C
R
S
V
G
L
P
T
K
L
A
D
L
G
I
V
D
D
V
P
A
K
I
G
-
R
V
A
E
A
A
C
R
P
G
---
N
I
I
Y
A
T
P
V
T
I
T
V
P
A
V
R
D
A
I
L
A
L
D
A
F
S
R
S
----
29
HHSearch
75.29
44%
-3
- C2 -
-
1KQ3
1
GLDA_THEMA
A:
[14-370]
--
I
T
T
T
I
F
P
G
R
Y
V
Q
G
A
G
A
I
N
I
L
E
E
E
L
S
R
F
G
-
E
R
A
-
F
V
V
I
D
D
F
V
-
D
K
N
V
----
L
G
E
N
F
F
S
S
F
T
K
V
R
V
N
---
K
Q
I
F
G
G
E
C
S
D
E
E
I
E
R
L
S
G
L
V
-
E
E
E
T
D
V
V
V
G
I
G
G
G
K
T
L
D
T
A
K
A
V
A
Y
K
------------------
L
K
K
P
V
V
I
V
P
T
I
A
S
T
D
A
P
C
S
A
L
S
V
I
Y
T
P
N
G
E
-
F
K
R
Y
L
F
L
-
P
R
N
P
D
V
V
L
V
D
T
E
I
V
A
K
A
P
A
R
F
L
V
A
G
M
G
D
A
L
A
T
W
F
E
A
E
S
C
K
Q
K
Y
A
P
N
M
------
T
G
R
L
G
S
M
T
-
A
Y
A
L
A
R
L
C
Y
E
T
L
L
E
Y
G
V
L
--------
A
K
R
--------
S
V
E
E
K
S
V
T
P
A
L
E
K
I
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
I
H
N
G
L
T
V
L
E
-
N
T
H
K
Y
L
H
G
E
K
V
A
I
--
G
V
L
A
S
L
F
L
--------------
T
D
K
---------
P
R
K
M
I
E
E
V
Y
S
F
C
E
E
V
G
L
P
T
T
L
A
E
I
G
L
D
G
V
S
D
E
D
L
M
-
K
V
A
E
K
A
C
D
K
N
---
E
T
I
H
N
E
P
Q
P
V
T
S
K
D
V
F
F
A
L
K
A
A
D
R
Y
G
R
-----
31
HHSearch
58.23
21%
-20
- C2 -
-
3OX4
1
ADH2_ZYMMO
B:
[4-382]
---
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
-
L
I
V
S
D
A
F
M
-
N
K
S
G
----
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
ATNGGEVKDYEGIDKSKK
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
-
H
V
K
M
A
I
V
DR
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
------------
T
P
I
T
D
A
C
-
A
L
K
A
A
S
M
I
A
K
N
L
K
----
T
--------
A
C
D
--------
N
G
K
---
D
M
P
A
R
E
A
M
A
Y
A
-
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
----
N
L
P
H
G
V
C
N
A
V
LL
P
H
V
L
A
Y
N
A
SVVAGRLKDVGVAM
G
L
D
IANLGDKEG
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
---
K
E
D
V
P
-
L
L
A
D
H
A
L
K
D
A
----
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
----------