@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0245: (2017-12-18 )
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFALIDSENPDVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE
Atome Classification :
(31 SA)
.........10........20........30........-40...--.....50....--...--.60........70........80........90........100.......110-.-......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260--.........--270------...-.--.-..280-...---......290.......300.......310.......320......-.330........340----........350.......360..-.---....370.......380.......390.......400.......410.......420.......430.......440.......450.......-460.......470.......480.......490.......500.......510.......520.....----..530-.......540......---.550---...-..-..560-----..----.....570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MC
G
I
V
G
VVGNT
N
A
T
D
I
L
I
Q
G
L
E
K
L
EYRGYDSA
G
I
F
V
L
DG-AD
N
H
L
--
V
K
A
V
G
R
I
A
E
L
S--AKT--AGVEGTTGIGHTRWATHGKPTEDNAHPHRSET
E
R
F
V
L
V
H
N
G
V
I
E
N
Y
L
E
I
K
E
E
Y
L-A-GHHFKGQTD
T
E
I
A
V
H
L
I
G
K
F
A
EED
G
L
S
V
L
E
A
F
K
K
A
L
H
I
IRG
S
Y
A
F
A
L
I
DSENP
D
V
I
Y
V
AKNKS
P
L
L
I
G
LGEGY
N
M
V
C
S
D
A
M
A
M
I
R
ET
N
Q
Y
M
E
IHD
Q
E
L
V
I
V
KAD
S
V
E
V
QDYDGNSR
E
R
A
S
Y
T
A
E
L
D
L
S
DIGKGTY
P
Y
Y
M
L
K
EIDEQ
P
----
T
V
M
R
K
L
I
Q
A
--YTD------DAG-
Q
--
V
-
V
I
D
---
P
A
I
---
I
K
A
VQDA
D
R
I
Y
I
L
AAGTSYHAG
F
A
S
K
K
M
L
E
E
LTDT
P
V
E
LGISSEW-GYG-MPLLSKK
P
L
F
-----
I
F
ISQSGETADS
R
Q
V
L
V
K
ANEMG-I---P
S
L
T
V
TNVPGSTLSREA
N
Y
T
M
L
L
HAGP
E
I
A
V
A
ST
K
A
Y
T
A
Q
I
A
A
L
A
F
L
A
K
A
V
GEANGNA
K
A
Q
A
F
D
L
V
H
E
L
S
I
V
A
Q
S
I
E
S
T
LSE
K
E
T
I
E
A
K
V
R
E
L
L
-
E
T
TRN
A
F
Y
IGRG
Q
D
Y
Y
V
A
M
E
A
S
L
K
L
K
E
I
S
Y
I
Q
CEGFAAGELKH
G
T
I
A
L
IEEG
T
P
V
L
A
LLSDPVLANHT----RG
N
I
Q
-
E
V
A
ARG
A
K
V
L
T
I
A
E
E
N---VAKD---TD
D
-
I
V
-
L
T
TV
H
-----
P
Y
----LS
P
I
S
M
V
V
P
T
Q
L
V
A
Y
F
A
T
L
H
RGLDVD
K
P
R
N
L
A
K
SVTVE
3
PsiBlast_PDB
84.80
40%
14
- C2 -
-
2J6H
3
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AG
F
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
1
PsiBlast_PDB
84.44
40%
17
- C2 -
-
4AMV
1
GLMS_ECOLI
A:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
25
PsiBlast_CBE
84.12
40%
17
- C2 -
-
2J6H
3
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
22
PsiBlast_CBE
83.94
40%
14
- C2 -
-
4AMV
2
GLMS_ECOLI
B:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
21
PsiBlast_CBE
83.87
40%
14
- C2 -
-
4AMV
2
GLMS_ECOLI
C:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
26
PsiBlast_CBE
81.90
39%
18
- C2 -
-
3OOJ
14
GLMS_ECOLI
H:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
29
PsiBlast_CBE
81.85
39%
16
- C2 -
-
3OOJ
2
GLMS_ECOLI
E:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
GF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
32
PsiBlast_CBE
81.67
39%
20
- C2 -
-
3OOJ
7
GLMS_ECOLI
B:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
E
L
G
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
2
PsiBlast_PDB
81.14
40%
11
- C2 -
-
1JXA
1
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AG
F
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
27
PsiBlast_CBE
81.01
39%
19
- C2 -
-
3OOJ
14
GLMS_ECOLI
G:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
---
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
31
PsiBlast_CBE
80.69
39%
17
- C2 -
-
3OOJ
7
GLMS_ECOLI
C:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
-------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
6
PsiBlast_PDB
80.67
39%
18
- C2 -
-
3OOJ
7
GLMS_ECOLI
A:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AG
F
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
28
PsiBlast_CBE
80.57
39%
20
- C2 -
-
3OOJ
1
GLMS_ECOLI
F:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
--------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
30
PsiBlast_CBE
80.51
39%
22
- C2 -
-
3OOJ
7
GLMS_ECOLI
D:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
------
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
E
L
G
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
24
PsiBlast_CBE
80.31
40%
12
- C2 -
-
1JXA
1
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
61
HHSearch
80.16
39%
-1
- C2 -
-
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
--
L
R
R
L
G
K
V
Q
M
L
A
--
Q
A
A
EE
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
G
Q
V
D
--
L
S
E
L
G
---
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
-
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
-
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
---
A
G
F
V
SSD
N
M
H
I
I
E
-
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
23
PsiBlast_CBE
78.25
40%
18
- C2 -
-
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
--
A
E
G
H
M
TR
L
R
R
L
G
K
V
Q
M
L
A
QA
A
E
E
--
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
-
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
-
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
7
PsiBlast_PDB
77.19
57%
-112
- C2 -
-
4S1W
2
?
A:
[5-342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
----
A
V
M
R
R
I
I
Q
E
--
Y
Q
D
------
A
E
G
-
N
--
L
-
K
I
D
---
Q
D
I
---
I
N
D
V
K
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
W
A
G
V
P
T
E
V
H
V
A
S
E
F
-
V
Y
N
-
M
P
L
L
S
E
K
P
L
F
-----
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
L
G
-
H
---
K
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
P
E
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
H
----
E
A
D
I
D
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
P
I
M
E
Q
I
A
T
D
F
L
-
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
E
G
A
L
K
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
V
N
L
S
I
----
R
G
N
V
K
-
E
V
V
A
R
G
A
H
P
C
I
I
S
M
E
G
---
L
E
K
E
---
G
D
T
-
Y
V
-
I
P
H
V
H
-----
E
L
----
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
----------------
67
HHSearch
75.82
59%
-80
- C2 -
-
4S1W
1
?
B:
[3-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
----
A
V
M
R
R
I
I
Q
E
--
Y
Q
D
------
A
E
G
-
N
--
L
-
K
I
D
---
Q
D
I
---
I
N
D
V
K
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
W
A
G
V
P
T
E
V
H
V
A
S
E
F
-
V
Y
N
-
M
P
L
L
S
E
K
P
L
F
-----
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
L
G
-
H
---
K
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
P
E
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
H
--
E
A
--
D
I
D
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
P
I
M
E
Q
I
A
T
D
-
F
L
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
E
G
A
L
K
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
V
N
L
S
I
----
R
G
N
V
K
-
E
V
V
A
R
G
A
H
P
C
I
I
S
M
E
G
---
L
E
K
----
E
G
D
T
Y
V
-
I
P
H
V
H
-----
E
L
----
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
L
D
V
D
K
-----------
76
HHSearch
63.04
40%
-9
- C2 -
-
1MOQ
3
GLMS_ECOLI
A:
[4-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
G
Q
V
D
L-
S
-
E
L
G
---
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
-
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
-
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
---
A
G
F
V
S
S
D
N
M
H
I
I
E
-
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
8
PsiBlast_PDB
61.91
40%
-5
- C2 -
-
1MOS
2
GLMS_ECOLI
A:
[5-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AG
F
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
17
PsiBlast_PDB
61.84
36%
-0
- C2 -
-
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
F
DD
Y
T
V
------
N
L
G
-
G
--
L
-------
K
D
H
---
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
-
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
L
Y
-
H
-
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
----
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
-
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
---
D
T
E
T
---
I
K
N
-
T
K
-
R
T
I
K
V
-----
P
H
S
VDC
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
9
PsiBlast_PDB
61.04
40%
-3
- C2 -
-
1MOQ
3
GLMS_ECOLI
A:
[5-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AG
F
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
18
PsiBlast_PDB
60.97
36%
2
- C2 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
R
G
R
V
N
F
DD
Y
T
V
------
N
L
G
-
G
--
L
-------
K
D
H
---
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
-
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
L
Y
-
H
-
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
----
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
-
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
---
D
T
E
T
---
I
K
N
-
T
K
-
R
T
I
K
V
-----
P
H
S
V
DC
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
10
PsiBlast_PDB
60.89
40%
-4
- C2 -
-
1MOR
1
GLMS_ECOLI
A:
[5-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AG
F
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
5
PsiBlast_PDB
60.86
40%
-2
- C2 -
-
2VF5
1
GLMS_ECOLI
X:
[243-608]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
-
G
-
Q
--
V
-
D
L
S
ELG
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
-
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
---
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
-
L
A
E
D
F
-
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
----
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
AGF
V
S
S
D
---
N
M
H
-
I
I
E
M
P
H
V
E
-----
E
V
----
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
65
HHSearch
60.21
36%
9
- C2 -
-
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
----
E
S
V
V
N
T
M
R
G
--
R
V
N
FDDYTV
N
L
G
-
G
--
L
-
K
------
D
H
---
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
-
N
T
P
V
F
R
D
D
V
C
-----
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
-
L
-
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
----
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
---
T
E
T
I
K
N
-
T
K
R
T
I
K
-
V
P
H
S
V
-----
D
C
----
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
66
HHSearch
59.97
36%
8
- C2 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
----
E
S
V
V
N
T
M
R
G
--
R
V
N
FDDYTV
N
L
G
-
G
--
L
-
K
------
D
H
---
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
-
N
T
P
V
F
R
D
D
V
C
-----
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
-
L
-
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
----
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
---
T
E
T
I
K
N
-
T
K
R
T
I
K
-
V
P
H
S
V
-----
D
C
----
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
33
PsiBlast_CBE
57.35
35%
-21
- C2 -
-
2PUW
1
GFA1_CANAL
B:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
----
D
S
A
F
N
T
M
R
G
--
R
I
D
------
F
E
N
-
C
--
V
-
V
T
L
---
G
G
L
KSW
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
-
A
---
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
S
S
----
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
----
M
S
A
I
E
-
Q
V
T
A
R
D
G
R
P
I
V
I
C
N
E
G
---
D
-----------
V
-
H
T
T
L
E
V
P
E
TV
D
C
----
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
15
PsiBlast_PDB
57.16
35%
-12
- C2 -
-
2PUW
2
GFA1_CANAL
A:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
----
D
S
A
F
N
T
M
R
G
--
R
I
D
------
F
E
N
-
C
--
V
-
V
T
L
---
G
G
L
KSW
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
-
A
---
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
N
S
S
----
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
---------
E
D
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
----
M
S
A
I
E
-
Q
V
T
A
R
D
G
R
P
I
V
I
C
N
E
G
---
D
A
I
I
---
S
N
D
-
K
V
-
H
T
T
L
E
V
P
E
T
V
D
C
----
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
57
Fugue
41.35
37%
-14
- C2 -
-
1MOQ
2
?
?:
[3-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
--
R
I
S
------
H
G
Q
-
V
DL
S
-
E
L
G
---
P
N
A
---
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
-
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
---GYL
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------