@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0262: (2017-12-18 )
MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHVAHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRETLCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKVEPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVEDVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSIRAGGRVVAVGLPSEMMELSIVKTVLDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMVLDFTH
Atome Classification :
(24 SA)
........-.10...-.....20........30........40........50--.....--.-----------.--..60........70........80..-......90........100.......110.......120.......130.......140.......150.......160..-.....170........180.......190.......200.......210.......220.......230.......240.......250.......260.......270........280.......290.......300.......310........320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
A
V
V
VNP-ESTG
V
A
-
I
E
E
K
VLRPLETG
E
A
L
V
E
V
E
Y
CGVCHT
D
L
H
V
AHGDFG---QVP
G
R
--
V
-----------L--GHE
G
I
G
I
V
K
E
IAP
D
V
K
SLKVGD
R
V
S
V
-
A
W
F
FEGCGT
C
E
Y
CTT
G
R
E
T
L
C
R
T
V
K
NAGYSVDGGMA
E
Q
C
I
V
TA
D
Y
A
V
KVPDGLDPAQAS
S
I
T
CA
G
V
T
T
Y
K
A
I
K
E
AKVEPG
Q
-
W
V
V
L
YG-AG
G
L
G
N
L
A
V
Q
Y
A
K
K
V
FN
A
H
V
I
A
V
DINND
K
L
A
L
A
K
EVGA
D
I
V
I
NGL
E
V
E
D
V
A
G
L
I
K
EKTDGG
A
H
S
A
V
V
T
A
V
S
K
V
A
F
N
Q
A
V
D
S
I
RAG
G
R
V
V
A
VGL
P
S
E
M
M
E
L
S
-
I
V
K
T
V
L
D
G
I
Q
V
I
G
S
L
VG
T
R
K
D
L
E
E
A
F
Q
FGAE
G
L
V
V
P
V
VQK-RP
V
E
D
A
V
A
I
F
D
E
M
E
KGQIQ
G
R
M
V
L
DFTH
25
PsiBlast_CBE
98.27
67%
-112
- C1 -
-
4GKV
3
ADHP_ECOLI
B:
[1-336]
M
K
A
A
V
V
T
K
-
D
H
H
-
V
D
-
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
G
D
F
G
---
D
K
T
G
V
--
I
-----------
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
-
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
R
S
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
C
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
S
A
A
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
V
K
L
S
K
I
R
P
G
Q
-
W
I
A
I
Y
G
-
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
-
H
T
E
D
A
A
K
I
V
Q
E
K
T
-
G
G
A
H
A
A
V
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
M
S
L
D
-
I
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
A
L
-
R
P
L
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
R
H
24
PsiBlast_CBE
98.08
67%
-112
- C1 -
-
4GKV
3
ADHP_ECOLI
C:
[1-336]
M
K
A
A
V
V
T
K
-
D
H
H
-
V
D
-
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
G
D
F
G
---
D
K
T
G
V
--
I
-----------
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
-
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
R
S
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
C
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
S
A
A
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
V
K
L
S
K
I
R
P
G
Q
-
W
I
A
I
Y
G
-
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
-
H
T
E
D
A
A
K
I
V
Q
E
K
T
-
G
G
A
H
A
A
V
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
M
S
L
D
-
I
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
A
L
-
R
P
L
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
R
H
3
PsiBlast_PDB
97.81
67%
-113
- C1 -
-
4GKV
2
ADHP_ECOLI
A:
[1-336]
M
K
A
A
V
V
T
K
-
D
H
H
-
V
D
-
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
G
D
F
G
---
D
K
T
G
V
--
I
-----------
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
-
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
R
S
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
C
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
S
A
A
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
V
K
L
S
K
I
R
P
G
Q
-
W
I
A
I
Y
G
-
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
-
H
T
E
D
A
A
K
I
V
Q
E
K
T
-
G
G
A
H
A
A
V
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
M
S
L
D
-
I
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
A
L
-
R
P
L
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
R
H
23
PsiBlast_CBE
96.79
67%
-112
- C1 -
-
4GKV
2
ADHP_ECOLI
D:
[1-336]
M
K
A
A
V
V
T
K
-
D
H
H
-
V
D
-
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
G
D
F
G
---
D
K
T
G
V
--
I
-----------
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
-
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
R
S
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
C
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
S
A
A
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
V
K
L
S
K
I
R
P
G
Q
-
W
I
A
I
Y
G
-
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
-
H
T
E
D
A
A
K
I
V
Q
E
K
T
-
G
G
A
H
A
A
V
V
T
A
V
A
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
M
S
L
D
-
I
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
A
L
-
R
P
L
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
R
H
143
HHSearch
90.33
64%
-107
- C1 -
-
4GKV
3
ADHP_ECOLI
B:
[1-335]
M
K
A
A
V
V
T
K
-
D
-
H
H
V
D
-
V
T
Y
K
T
L
R
S
L
K
H
G
E
A
L
L
K
M
E
C
C
G
V
C
H
T
D
L
H
V
K
N
G
D
F
G
---
D
K
T
G
V
--
I
-----------
L
--
G
H
E
G
I
G
V
V
A
E
V
G
P
G
V
T
S
L
K
P
G
D
R
A
S
V
-
A
W
F
Y
E
G
C
G
H
C
E
Y
C
N
S
G
N
E
T
L
C
R
S
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
C
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
S
A
A
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
V
K
L
S
K
I
R
P
G
Q
-
W
I
A
I
Y
G
-
L
G
G
L
G
N
L
A
L
Q
Y
A
K
N
V
F
N
A
K
V
I
A
I
D
V
N
D
E
Q
L
K
L
A
T
E
M
G
A
D
L
A
I
N
S
H
T
E
D
A
A
K
I
V
Q
E
K
T
G
G
A
H
A
-
A
V
V
T
A
V
A
-
K
A
A
F
N
S
A
V
D
A
V
R
A
G
G
R
V
V
A
V
G
L
P
P
E
S
M
S
L
D
-
I
P
R
L
V
L
D
G
I
E
V
V
G
S
L
V
G
T
R
Q
D
L
T
E
A
F
Q
F
A
A
E
G
K
V
V
P
K
V
A
L
-
R
P
L
A
D
I
N
T
I
F
T
E
M
E
E
G
K
I
R
G
R
M
V
I
D
F
R
-
2
PsiBlast_PDB
86.61
64%
-38
- C1 -
-
4EEZ
1
?
A:
[1-339]
M
K
A
A
V
V
R
H
-
N
P
D
G
Y
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
G
D
F
G
---
N
K
A
G
T
--
V
-----------
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
-
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
R
E
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
A
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
P
I
E
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
I
K
V
S
G
V
K
P
G
D
-
W
Q
V
I
F
G
-
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
T
I
N
S
G
D
V
N
P
V
D
E
I
K
K
I
T
G
G
L
G
V
Q
S
A
I
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
V
P
N
T
E
M
T
L
S
-
V
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
A
T
-
R
K
L
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
T
-
22
PsiBlast_CBE
85.49
64%
-38
- C1 -
-
4EEZ
1
?
B:
[1-339]
M
K
A
A
V
V
R
H
-
N
P
D
G
Y
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
G
D
F
G
---
N
K
A
G
T
--
V
-----------
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
-
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
R
E
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
A
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
P
I
E
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
I
K
V
S
G
V
K
P
G
D
-
W
Q
V
I
F
G
-
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
T
I
N
S
G
D
V
N
P
V
D
E
I
K
K
I
T
G
G
L
G
V
Q
S
A
I
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
V
P
N
T
E
M
T
L
S
-
V
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
A
T
-
R
K
L
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
T
-
1
PsiBlast_PDB
83.49
64%
-43
- C1 -
-
4EEX
1
?
A:
[1-339]
M
K
A
A
V
V
R
H
-
N
P
D
G
Y
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
G
D
Y
G
---
N
K
A
G
T
--
V
-----------
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
-
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
R
E
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
A
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
P
I
E
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
I
K
V
S
G
V
K
P
G
D
-
W
Q
V
I
F
G
-
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
I
I
N
S
G
D
V
N
P
V
D
E
I
K
K
I
T
G
G
L
G
V
Q
S
A
I
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
L
P
N
T
E
M
T
L
S
-
V
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
A
T
-
R
K
L
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
T
-
5
PsiBlast_PDB
83.34
55%
-48
- C1 -
-
3PII
2
ADH3_GEOSE
A:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
F
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
142
HHSearch
82.98
64%
-37
- C1 -
-
4EEZ
1
?
B:
[1-339]
M
K
A
A
V
V
R
H
N
P
D
G
Y
A
D
-
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
G
D
F
G
---
N
K
A
G
T
--
V
-----------
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
-
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
R
E
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
A
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
P
I
E
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
I
K
V
S
G
V
K
P
G
D
-
W
Q
V
I
F
G
-
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
T
I
N
S
G
D
V
N
P
V
D
E
I
K
K
I
T
G
G
L
G
V
Q
S
A
I
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
V
P
N
T
E
M
T
L
S
-
V
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
A
T
-
R
K
L
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
T
-
21
PsiBlast_CBE
82.08
64%
-34
- C1 -
-
4EEX
1
?
B:
[1-339]
M
K
A
A
V
V
R
H
-
N
P
D
G
Y
A
D
L
V
E
K
E
L
R
A
I
K
P
N
E
A
L
L
D
M
E
Y
C
G
V
C
H
T
D
L
H
V
A
A
G
D
Y
G
---
N
K
A
G
T
--
V
-----------
L
--
G
H
E
G
I
G
I
V
K
E
I
G
A
D
V
S
S
L
Q
V
G
D
R
V
S
V
-
A
W
F
F
E
G
C
G
H
C
E
Y
C
V
S
G
N
E
T
F
C
R
E
V
K
N
A
G
Y
S
V
D
G
G
M
A
E
E
A
I
V
V
A
D
Y
A
V
K
V
P
D
G
L
D
P
I
E
A
S
S
I
T
C
A
G
V
T
T
Y
K
A
I
K
V
S
G
V
K
P
G
D
-
W
Q
V
I
F
G
-
A
G
G
L
G
N
L
A
I
Q
Y
A
K
N
V
F
G
A
K
V
I
A
V
D
I
N
Q
D
K
L
N
L
A
K
K
I
G
A
D
V
I
I
N
S
G
D
V
N
P
V
D
E
I
K
K
I
T
G
G
L
G
V
Q
S
A
I
V
C
A
V
A
R
I
A
F
E
Q
A
V
A
S
L
K
P
M
G
K
M
V
A
V
A
L
P
N
T
E
M
T
L
S
-
V
P
T
V
V
F
D
G
V
E
V
A
G
S
L
V
G
T
R
L
D
L
A
E
A
F
Q
F
G
A
E
G
K
V
K
P
I
V
A
T
-
R
K
L
E
E
I
N
D
I
I
D
E
M
K
A
G
K
I
E
G
R
M
V
I
D
F
T
-
31
PsiBlast_CBE
80.84
55%
-49
- C1 -
-
3PII
2
ADH3_GEOSE
B:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
F
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
4
PsiBlast_PDB
80.48
55%
-47
- C1 -
-
1RJW
2
ADH3_GEOSE
A:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
26
PsiBlast_CBE
80.22
55%
-45
- C1 -
-
1RJW
4
ADH3_GEOSE
D:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
30
PsiBlast_CBE
80.17
55%
-49
- C1 -
-
3PII
2
ADH3_GEOSE
C:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
F
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
28
PsiBlast_CBE
80.00
55%
-47
- C1 -
-
1RJW
4
ADH3_GEOSE
B:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
27
PsiBlast_CBE
79.45
55%
-44
- C1 -
-
1RJW
3
ADH3_GEOSE
C:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
29
PsiBlast_CBE
78.77
55%
-48
- C1 -
-
3PII
1
ADH3_GEOSE
D:
[1-336]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
---
V
K
P
K
L
--
P
-----------
L
IP
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
F
G
H
V
A
V
Q
Y
A
-
K
A
M
G
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
-
E
D
A
A
K
F
M
K
E
K
V
-
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
--
156
HHSearch
74.92
54%
-43
- C1 -
-
1RJW
3
ADH3_GEOSE
C:
[1-337]
M
K
A
A
V
V
E
Q
-
F
K
E
P
L
K
-
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
G
D
W
P
VK-
P
K
L
P
L
--
I
-----------
P
--
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
-
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
-
W
V
A
I
Y
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
-
L
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
--
G
G
V
H
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
-
I
F
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
I
I
E
V
-
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
K
G
Q
I
N
G
R
V
V
L
T
L
E
-
49
PsiBlast_CBE
74.77
42%
-44
- C1 -
-
3S2I
1
?
D:
[3-340]
M
K
A
A
V
V
R
A
-
F
G
A
P
L
T
-
I
D
E
V
P
V
P
Q
P
G
P
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
D
G
D
W
P
---
V
K
P
T
L
PF
I
-----------
P
--
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
R
V
K
E
G
D
R
V
G
V
-
P
W
L
Y
S
A
C
G
Y
C
E
H
C
L
Q
G
W
E
T
L
C
E
K
Q
Q
N
T
G
Y
S
V
N
G
G
Y
G
E
Y
V
V
A
D
P
N
Y
V
G
L
L
P
D
K
V
G
F
V
E
I
A
P
I
L
C
A
G
V
T
V
Y
K
G
L
K
V
T
D
T
R
P
G
Q
-
W
V
V
I
S
G
-
I
G
G
L
G
H
V
A
V
Q
Y
A
-
R
A
M
G
L
R
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
R
D
T
D
P
A
A
W
L
Q
K
E
I
--
G
G
A
H
G
V
L
V
T
A
V
S
P
K
A
F
S
Q
A
I
G
M
V
R
R
G
G
T
I
A
L
N
G
L
P
P
G
D
F
G
T
P
-
I
F
D
V
V
L
K
G
I
T
I
R
G
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
A
T
V
S
T
-
A
K
L
D
D
V
N
D
V
F
G
R
L
R
E
G
K
V
E
G
R
V
V
L
D
F
S
R
15
PsiBlast_PDB
60.40
39%
-22
- C1 -
-
5ENV
3
ADH1_YEAST
A:
[25-344]
--------------------
V
P
K
P
-
K
A
N
E
L
L
I
N
V
K
Y
S
G
V
C
H
T
D
L
H
A
W
H
G
D
W
P
LPV
K
L
P
-
L
--
V
-----------
G
--
G
H
E
G
A
G
V
V
V
G
M
G
E
N
V
K
G
W
K
I
G
D
Y
A
G
I
-
K
W
L
N
G
S
C
M
A
C
E
Y
C
E
L
G
N
E
S
N
C
P
H
A
D
L
S
G
Y
T
H
D
G
S
F
Q
Q
Y
A
T
A
D
A
V
Q
A
A
H
I
P
Q
G
T
D
L
A
Q
V
A
P
I
L
C
A
G
I
T
V
Y
K
A
L
K
S
A
N
L
M
A
G
H
-
W
V
A
I
S
G
A
A
G
G
L
G
S
L
A
V
Q
Y
A
-
K
A
M
G
Y
R
V
L
G
I
D
G
G
E
G
K
E
E
L
F
R
S
I
G
G
E
V
F
I
D
F
T
K
E
K
D
I
V
G
A
V
L
K
A
T
D
G
G
A
H
G
V
I
N
V
S
V
S
E
A
A
I
E
A
S
T
R
Y
V
R
A
N
G
T
T
V
L
V
G
M
P
A
G
A
K
C
C
S
D
V
F
N
Q
V
V
K
S
I
S
I
V
G
S
Y
V
G
N
R
A
D
T
R
E
A
L
D
F
F
A
R
G
L
V
K
S
P
I
K
V
-
V
G
L
S
T
L
P
E
I
Y
E
K
M
E
K
G
Q
I
V
G
R
Y
V
V
D
---
76
PsiBlast_CBE
56.20
39%
-24
- C1 -
-
5ENV
3
ADH1_YEAST
B:
[25-344]
--------------------
V
P
K
P
-
K
A
N
E
L
L
I
N
V
K
Y
S
G
V
C
H
T
D
L
H
A
W
H
G
D
W
P
LPV
K
L
P
-
L
--
V
-----------
G
--
G
H
E
G
A
G
V
V
V
G
M
G
E
N
V
K
G
W
K
I
G
D
Y
A
G
I
-
K
W
L
N
G
S
C
M
A
C
E
Y
C
E
L
G
N
E
S
N
C
P
H
A
D
L
S
G
Y
T
H
D
G
S
F
Q
Q
Y
A
T
A
D
A
V
Q
A
A
H
I
P
Q
G
T
D
L
A
Q
V
A
P
I
L
C
A
G
I
T
V
Y
K
A
L
K
S
A
N
L
M
A
G
H
-
W
V
A
I
S
G
A
A
G
G
L
G
S
L
A
V
Q
Y
A
-
K
A
M
G
Y
R
V
L
G
I
D
G
G
E
G
K
E
E
L
F
R
S
I
G
G
E
V
F
I
D
F
T
K
E
K
D
I
V
G
A
V
L
K
A
T
D
G
G
A
H
G
V
I
N
V
S
V
S
E
A
A
I
E
A
S
T
R
Y
V
R
A
N
G
T
T
V
L
V
G
M
P
A
G
A
K
C
C
S
D
V
F
N
Q
V
V
K
S
I
S
I
V
G
S
Y
V
G
N
R
A
D
T
R
E
A
L
D
F
F
A
R
G
L
V
K
S
P
I
K
V
-
V
G
L
S
T
L
P
E
I
Y
E
K
M
E
K
G
Q
I
V
G
R
Y
V
V
D
---
93
PsiBlast_CBE
44.19
32%
-8
- C1 -
-
1R37
3
ADH_SULSO
A:
[27-345]
----------------------------
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
G
R
F
G
---
N
L
--
R
--
I
VEDLGVKLP
V
T
L
--
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
G
Y
S
K
G
D
L
V
A
V
N
P
W
--
Q
G
E
G
N
C
Y
Y
C
R
I
G
E
E
H
L
C
D
S
P
R
W
L
G
I
N
F
D
G
A
Y
A
E
Y
V
I
V
P
H
Y
K
Y
M
Y
K
L
R
R
L
N
A
V
E
A
A
P
L
T
C
S
G
I
T
T
Y
R
A
V
R
K
A
S
L
D
P
T
K
T
L
L
V
V
G
A
-
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
M
Q
D
P
L
A
E
I
R
R
I
T
E
S
K
G
V
D
A
V
I
D
L
N
N
S
E
K
T
L
S
V
Y
P
K
A
L
A
K
Q
G
K
Y
V
M
V
G
L
F
G
A
D
L
H
Y
H
-
A
P
L
I
T
L
S
E
I
Q
F
V
G
S
L
V
G
N
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
P
M
I
T
K
T
M
K
L
E
E
A
N
E
A
I
D
N
L
E
N
F
K
A
I
G
R
Q
V
L
----
92
PsiBlast_CBE
43.52
32%
-8
- C1 -
-
1R37
4
ADH_SULSO
B:
[27-345]
----------------------------
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
Q
G
R
F
G
---
N
L
--
R
--
I
VEDLGVKLPVT
L
--
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
G
Y
S
K
G
D
L
V
A
V
N
P
W
--
Q
G
E
G
N
C
Y
Y
C
R
I
G
E
E
H
L
C
D
S
P
R
W
L
G
I
N
F
D
G
A
Y
A
E
Y
V
I
V
P
H
Y
K
Y
M
Y
K
L
R
R
L
N
A
V
E
A
A
P
L
T
C
S
G
I
T
T
Y
R
A
V
R
K
A
S
L
D
P
T
K
T
L
L
V
V
G
A
-
G
G
G
L
G
T
M
A
V
Q
I
A
K
A
V
S
G
A
T
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
S
M
Q
D
P
L
A
E
I
R
R
I
T
E
S
K
G
V
D
A
V
I
D
L
N
N
S
E
K
T
L
S
V
Y
P
K
A
L
A
K
Q
G
K
Y
V
M
V
G
L
F
G
A
D
L
H
Y
H
-
A
P
L
I
T
L
S
E
I
Q
F
V
G
S
L
V
G
N
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
P
M
I
T
K
T
M
K
L
E
E
A
N
E
A
I
D
N
L
E
N
F
K
A
I
G
R
Q
V
L
----