@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0268: (2017-12-18 )
MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGLGQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKLARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVIIEAEHMCMSMRGVRKPGTATLTTVARGLFETDKDLRDQAYRLMGL
Atome Classification :
(36 SA)
-----------.........10........20........30......-.-.-40........50-...-.-.-..--..60---.........70........80........90.-.-......100.......110.......120.......130.......140.......150.......160.......170.......180..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------M
D
T
Q
K
I
E
A
A
V
K
M
I
I
E
A
VGEDANRE
G
L
Q
E
T
P
A
R
V
A
R
M
Y
-
Q
-
E
-
I
F
S
G
L
G
Q
T
A
E
E
--
H
L
S
-
K
-
S
-
F
E
--IID----DN
M
V
V
E
K
D
I
F
F
H
T
M
C
E
HHFLPFYGR
A
H
I
A
Y
IP-D-
G
R
V
A
G
L
S
K
L
A
R
T
V
E
V
Y
SKKP
Q
I
Q
E
R
L
N
I
E
V
A
D
A
L
M
D
Y
LGAK
G
A
F
V
I
I
E
A
E
H
M
C
M
S
M
RGVRKPG
T
A
T
L
T
T
V
A
R
G
L
FET
D
K
D
L
R
D
Q
A
Y
R
LMGL
176
HHSearch
88.33
54%
-
- C9 -
-
4UQF
-
GCH1_LISMO
E:
[5-187]
------------
D
K
Q
K
I
A
D
A
V
K
V
I
L
E
A
V
G
E
N
P
D
R
E
G
L
I
D
T
P
M
R
V
A
R
M
Y
-
E
-
E
-
V
F
A
G
L
K
K
D
P
S
V
--
H
F
D
-
T
-
I
-
F
E
--
E
Q
H
----
E
E
L
V
L
V
K
D
I
R
F
S
S
M
C
E
H
H
L
V
P
F
F
G
V
A
H
V
A
Y
L
P
-
Q
N
G
R
V
A
G
L
S
K
L
A
R
V
V
D
D
V
S
R
R
P
Q
L
Q
E
R
I
T
T
T
V
A
E
I
M
M
E
K
L
K
P
L
G
V
M
V
I
M
E
A
E
H
M
C
M
T
I
R
G
V
N
K
P
G
T
K
T
I
T
S
A
V
R
G
A
F
K
N
D
D
K
L
R
S
E
V
L
A
L
I
K
-
1
PsiBlast_PDB
87.19
53%
-
- C9 -
-
4UQF
-
GCH1_LISMO
A:
[4-186]
-----------
I
D
K
Q
K
I
A
D
A
V
K
V
I
L
E
A
V
G
E
N
P
D
R
E
G
L
I
D
T
P
M
R
V
A
R
M
Y
-
E
-
E
-
V
F
A
G
L
K
K
D
P
S
V
--
H
F
D
-
T
-
I
-
F
E
--
E
Q
H
----
E
E
L
V
L
V
K
D
I
R
F
S
S
M
C
E
H
H
L
V
P
F
F
G
V
A
H
V
A
Y
L
P
Q
N
-
G
R
V
A
G
L
S
K
L
A
R
V
V
D
D
V
S
R
R
P
Q
L
Q
E
R
I
T
T
T
V
A
E
I
M
M
E
K
L
K
P
L
G
V
M
V
I
M
E
A
E
H
M
C
M
T
I
R
G
V
N
K
P
G
T
K
T
I
T
S
A
V
R
G
A
F
K
N
D
D
K
L
R
S
E
V
L
A
L
I
--
47
PsiBlast_CBE
87.18
42%
0
- C- -
-
1IS7
14
GCH1_RAT
B:
[46-228]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
R
S
L
G
E
D
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
T
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
R
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
Q
P
A
G
V
G
V
V
I
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
4
PsiBlast_PDB
87.18
42%
0
- C- -
-
1WPL
-
GCH1_RAT
A:
[46-228]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
R
S
L
G
E
D
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
T
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
R
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
Q
P
A
G
V
G
V
V
I
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
2
PsiBlast_PDB
87.18
42%
0
- C- -
-
1IS7
-
GCH1_RAT
A:
[46-228]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
R
S
L
G
E
D
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
T
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
R
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
Q
P
A
G
V
G
V
V
I
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
180
HHSearch
84.24
43%
0
- C- -
-
1IS8
-
GCH1_RAT
B:
[47-229]
------------
N
L
P
N
L
A
A
A
Y
S
S
I
L
R
S
L
G
E
D
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
T
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
D
A
-
I
-
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
R
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
Q
P
A
G
V
G
V
V
I
E
A
T
H
M
C
M
V
M
R
G
--
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
R
-
3
PsiBlast_PDB
83.30
42%
0
- C- -
-
1IS8
-
GCH1_RAT
A:
[46-228]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
R
S
L
G
E
D
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
T
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
R
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
Q
P
A
G
V
G
V
V
I
E
A
T
H
M
C
M
V
M
R
G
--
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
49
PsiBlast_CBE
78.59
40%
-56
- C9 -
-
1FB1
2
GCH1_HUMAN
D:
[12-194]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
178
HHSearch
78.47
37%
0
- C- -
-
1N3T
9
GCH1_ECOLI
A:
[35-218]
------------
R
K
S
L
I
A
G
H
M
T
E
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
-
V
D
E
-
I
F
S
G
L
D
Y
A
N
F
P
--
K
I
--
T
-
L
-
I
E
NK
M
K
V
----
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
H
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
S
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
A
V
R
-
181
HHSearch
77.74
39%
-64
* C9 *
-
1WUR
2
?
C:
[34-216]
------------
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
G
A
-
V
-
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
F
L
S
H
L
R
-
179
HHSearch
77.37
41%
-53
- C9 -
-
1FB1
2
GCH1_HUMAN
E:
[13-195]
------------
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
D
A
-
I
-
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
R
-
48
PsiBlast_CBE
77.25
40%
-52
- C9 -
-
1FB1
2
GCH1_HUMAN
E:
[12-194]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
56
PsiBlast_CBE
76.67
39%
-63
- C9 -
-
1WUQ
2
?
E:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
50
PsiBlast_CBE
76.39
40%
-58
- C9 -
-
1FB1
2
GCH1_HUMAN
C:
[12-194]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
54
PsiBlast_CBE
76.07
39%
-58
- C9 -
-
1WUR
2
?
C:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
123
PsiBlast_CBE
76.03
38%
0
- C- -
-
1N3R
2
GCH1_ECOLI
B:
[46-215]
-----------------------
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
A
N
F
P
--
K
I
T
-
L
I
E
-
N
K
--
M
K
V
----
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
S
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
----
122
PsiBlast_CBE
76.03
38%
0
- C- -
-
1N3R
2
GCH1_ECOLI
C:
[46-215]
-----------------------
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
A
N
F
P
--
K
I
T
-
L
I
E
-
N
K
--
M
K
V
----
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
S
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
----
121
PsiBlast_CBE
76.03
38%
0
- C- -
-
1N3R
2
GCH1_ECOLI
D:
[46-215]
-----------------------
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
A
N
F
P
--
K
I
T
-
L
I
E
-
N
K
--
M
K
V
----
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
S
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
----
120
PsiBlast_CBE
76.03
38%
0
- C- -
-
1N3R
2
GCH1_ECOLI
E:
[46-215]
-----------------------
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
A
N
F
P
--
K
I
T
-
L
I
E
-
N
K
--
M
K
V
----
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
S
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
----
119
PsiBlast_CBE
76.03
38%
0
- C- -
-
1N3R
2
GCH1_ECOLI
F:
[46-215]
-----------------------
I
M
Q
L
L
N
L
D
L
A
D
D
S
L
M
E
T
P
H
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
A
N
F
P
--
K
I
T
-
L
I
E
-
N
K
--
M
K
V
----
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
S
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
I
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
H
E
F
L
R
----
53
PsiBlast_CBE
76.00
39%
-61
- C9 -
-
1WUR
2
?
D:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
8
PsiBlast_PDB
75.96
39%
-60
- C9 -
-
1WUR
2
?
A:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
59
PsiBlast_CBE
75.92
39%
-55
- C9 -
-
1WUQ
2
?
B:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
55
PsiBlast_CBE
75.86
39%
-58
- C9 -
-
1WUR
2
?
B:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
52
PsiBlast_CBE
75.79
39%
-59
- C9 -
-
1WUR
2
?
E:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
7
PsiBlast_PDB
75.62
39%
-60
- C9 -
-
1WUQ
2
?
A:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
5
PsiBlast_PDB
75.55
40%
-55
- C9 -
-
1FB1
2
GCH1_HUMAN
A:
[12-194]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
57
PsiBlast_CBE
75.48
39%
-58
- C9 -
-
1WUQ
2
?
D:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
58
PsiBlast_CBE
75.38
39%
-57
- C9 -
-
1WUQ
2
?
C:
[33-210]
-----------
V
D
L
E
R
L
Q
A
L
A
A
E
W
L
Q
V
I
G
E
D
P
G
R
E
G
L
L
K
T
P
E
R
V
A
K
A
W
-
A
-
F
-
L
T
R
G
Y
R
Q
R
L
E
E
--
V
V
G
-
G
-
A
V
F
P
--
A
E
G
----
S
E
M
V
V
V
K
G
V
E
F
Y
S
M
C
E
H
H
L
L
P
F
F
G
K
V
H
I
G
Y
I
P
-
D
-
G
K
I
L
G
L
S
K
F
A
R
I
V
D
M
F
A
R
R
L
Q
V
Q
E
R
L
A
V
Q
I
A
E
A
I
Q
E
V
L
E
P
Q
G
V
G
V
V
V
E
G
V
H
L
C
M
M
M
R
G
V
E
K
Q
H
S
R
T
V
T
S
A
M
L
G
V
F
R
E
N
Q
K
T
R
E
E
-------
51
PsiBlast_CBE
74.36
40%
-43
- C9 -
-
1FB1
2
GCH1_HUMAN
B:
[12-194]
-----------
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
-
F
-
F
T
K
G
Y
Q
E
T
I
S
D
--
V
L
N
-
D
-
A
I
F
D
--
E
D
H
----
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
--
67
PsiBlast_CBE
70.49
38%
-22
- C9 -
-
4DU6
6
GCH1_YERPE
B:
[40-217]
---------------
R
I
Q
A
H
M
T
E
V
M
H
L
L
N
L
D
L
T
D
D
S
L
A
D
T
P
R
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
---
E
--
N
F
P
-
K
-
I
-
T
L
--
I
Q
N
KMKV
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
H
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
L
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
Q
E
F
L
R
----
65
PsiBlast_CBE
70.27
38%
-25
- C9 -
-
4DU6
4
GCH1_YERPE
D:
[40-217]
---------------
R
I
Q
A
H
M
T
E
V
M
H
L
L
N
L
D
L
T
D
D
S
L
A
D
T
P
R
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
---
E
--
N
F
P
-
K
-
I
-
T
L
--
I
Q
N
KMKV
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
H
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
L
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
Q
E
F
L
R
----
66
PsiBlast_CBE
70.19
38%
-22
- C9 -
-
4DU6
6
GCH1_YERPE
C:
[40-217]
---------------
R
I
Q
A
H
M
T
E
V
M
H
L
L
N
L
D
L
T
D
D
S
L
A
D
T
P
R
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
---
E
--
N
F
P
-
K
-
I
-
T
L
--
I
Q
N
KMKV
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
H
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
L
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
Q
E
F
L
R
----
64
PsiBlast_CBE
70.13
38%
-16
- C9 -
-
4DU6
4
GCH1_YERPE
E:
[40-217]
---------------
R
I
Q
A
H
M
T
E
V
M
H
L
L
N
L
D
L
T
D
D
S
L
A
D
T
P
R
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
---
E
--
N
F
P
-
K
-
I
-
T
L
--
I
Q
N
KMKV
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
H
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
L
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
Q
E
F
L
R
----
9
PsiBlast_PDB
70.03
38%
-22
- C9 -
-
4DU6
4
GCH1_YERPE
A:
[40-217]
---------------
R
I
Q
A
H
M
T
E
V
M
H
L
L
N
L
D
L
T
D
D
S
L
A
D
T
P
R
R
I
A
K
M
Y
V
D
-
E
-
I
F
S
G
L
D
Y
---
E
--
N
F
P
-
K
-
I
-
T
L
--
I
Q
N
KMKV
D
E
M
V
T
V
R
D
I
T
L
T
S
T
C
E
H
H
F
V
T
I
D
G
K
A
T
V
A
Y
I
P
-
K
-
D
S
V
I
G
L
S
K
I
N
R
I
V
Q
F
F
A
Q
R
P
Q
V
Q
E
R
L
T
Q
Q
I
L
L
A
L
Q
T
L
L
G
T
N
N
V
A
V
S
I
D
A
V
H
Y
C
V
K
A
R
G
I
R
D
A
T
S
A
T
T
T
T
S
L
G
G
L
F
K
S
S
Q
N
T
R
Q
E
F
L
R
----
167
Fugue
69.27
41%
16
- C9 -
-
1FB1
2
GCH1_HUMAN
A:
[1-196]
G
E
R
P
R
S
E
E
D
N
E
L
N
L
P
N
L
A
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
M
-
Q
--
F
F
T
K
G
Y
Q
E
T
I
S
D
V
L
N
-
D
-
A
-
I
-
F
D
--
E
-
D
H---
D
E
M
V
I
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
P
F
V
G
K
V
H
I
G
Y
L
P
-
N
-
K
Q
V
L
G
L
S
K
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
R
L
T
K
Q
I
A
V
A
I
T
E
A
L
R
P
A
G
V
G
V
V
V
E
A
T
H
M
C
M
V
M
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
I
R
S