@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0290: (2017-12-19 )
MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVFNDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGIIRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFDQFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE
Atome Classification :
(25 SA)
.........10-........20........30........40........50........60-........70........80........90........100.......110.......120.......130.......140.-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTNT
S
F
S
I
E
Q
F
-
S
LKG
K
I
A
L
I
TGASY
G
I
G
F
A
I
A
K
S
Y
AEAG
A
T
I
V
F
NDI
N
Q
D
L
V
N
K
G
I
E
A
Y
R
E
-VGIEAH
G
Y
V
C
DVTDED
G
I
Q
A
M
V
K
Q
I
E
Q
EV
G
V
I
D
I
L
VNNAG
I
I
R
RVPMCEM
S
A
A
D
F
R
K
V
I
D
IDLNAP
F
I
V
S
K
A
V
I
P
S
M
I
K
KGH-GK
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
AAKG
G
L
K
M
L
T
R
N
I
A
S
E
YGG
A
N
I
Q
CNGIGPGYIATPQTA
P
L
R
E
L
Q
E
DGSRHPFD
Q
F
I
I
AKTPAARWG
N
P
E
D
LMG
P
A
V
F
L
ASD
A
S
NFVN
G
H
I
L
Y
VDG
G
I
L
A
YIGKQPE
2
PsiBlast_PDB
91.08
89%
-124
- C1 -
-
3O03
2
?
A:
[24-289]
----
Q
F
S
L
D
Q
F
-
S
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
Q
E
L
V
D
R
G
M
A
A
Y
K
A
-
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
Q
A
M
V
A
Q
I
E
S
E
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
M
I
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
G
H
-
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
------------
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
Q
P
-
1
PsiBlast_PDB
90.61
89%
-119
- C1 -
-
3CXR
-
?
A:
[4-269]
----
Q
F
S
L
D
Q
F
-
S
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
Q
E
L
V
D
R
G
M
A
A
Y
K
A
-
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
Q
A
M
V
A
Q
I
E
S
E
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
M
I
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
G
H
-
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
L
------
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
Q
P
-
4
PsiBlast_PDB
88.62
83%
-128
- C1 -
-
4U8G
-
?
A:
[5-267]
-----
F
L
K
D
N
F
-
S
L
E
G
K
V
A
L
I
T
G
A
S
Y
G
I
G
F
S
I
A
T
A
F
A
R
A
G
A
T
I
V
F
N
D
I
K
Q
E
L
V
D
K
G
I
S
A
Y
K
K
-
L
G
I
K
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
N
E
M
V
D
K
I
S
Q
D
V
G
V
I
D
I
L
V
N
N
A
G
I
I
K
R
T
P
M
L
E
M
S
A
A
D
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
L
P
G
M
I
Q
K
G
H
-
G
K
I
I
N
I
C
A
M
M
S
E
L
G
R
E
T
V
A
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
S
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
R
Q
D
D
G
S
R
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
G
A
P
A
I
F
L
A
S
D
A
S
N
F
I
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
---
3
PsiBlast_PDB
87.08
88%
-115
- C- -
-
4Z9X
-
?
A:
[5-264]
----------
F
-
S
L
Q
G
K
I
A
L
I
T
G
A
S
Y
G
I
G
F
E
I
A
K
A
Y
A
Q
A
G
A
T
I
V
F
N
D
I
K
Q
E
L
V
D
K
G
L
A
A
Y
R
E
-
L
G
I
E
A
H
G
Y
V
C
D
V
T
D
E
A
G
I
Q
Q
M
V
S
Q
I
E
D
E
V
G
A
I
D
I
L
V
N
N
A
G
I
I
R
R
T
P
M
L
E
M
A
A
E
D
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
L
P
S
M
I
A
K
G
H
-
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
F
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
R
-----
R
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
T
T
E
D
L
A
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
Q
P
-
29
PsiBlast_CBE
77.59
42%
-103
- C1 -
-
5U9P
7
?
B:
[10-265]
----
T
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
-
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
G
H
-
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
---
R
A
L
V
D
D
A
A
---
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
-----
27
PsiBlast_CBE
77.33
42%
-107
- C1 -
-
5U9P
5
?
D:
[10-265]
----
T
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
-
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
G
H
-
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
---
R
A
L
V
D
D
A
A
---
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
-----
7
PsiBlast_PDB
75.63
42%
-107
- C1 -
-
5U9P
7
?
A:
[10-265]
----
T
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
-
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
G
H
-
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
---
R
A
L
V
D
D
A
A
---
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
-----
28
PsiBlast_CBE
75.46
42%
-104
- C1 -
-
5U9P
7
?
C:
[11-265]
-----
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
-
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
G
H
-
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
---
R
A
L
V
D
D
A
A
---
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
-----
6
PsiBlast_PDB
72.82
44%
-102
- C1 -
-
4IBO
-
?
A:
[22-271]
----------
F
-
D
L
G
G
R
T
A
L
V
T
G
S
S
R
G
L
G
R
A
M
A
E
G
L
A
V
A
G
A
R
I
L
I
N
G
T
D
P
S
R
V
A
Q
T
V
Q
E
F
R
N
-
V
G
H
D
A
E
A
V
A
F
D
V
T
S
E
S
E
I
I
E
A
F
A
R
L
D
E
Q
G
I
D
V
D
I
L
V
N
N
A
G
I
Q
F
R
K
P
M
I
E
L
E
T
A
D
W
Q
R
V
I
D
T
N
L
T
S
A
F
M
I
G
R
E
A
A
K
R
M
I
P
R
G
Y
-
G
K
I
V
N
I
G
S
L
T
S
E
L
A
R
A
T
V
A
P
Y
T
V
A
K
G
G
I
K
M
L
T
R
A
M
A
A
E
W
A
Q
Y
G
I
Q
A
N
A
I
G
P
G
Y
M
L
T
D
M
N
Q
A
L
I
D
N
P
E
------
F
D
A
W
V
K
A
R
T
P
A
K
R
W
G
K
P
Q
E
L
V
G
T
A
V
F
L
S
A
S
A
S
D
Y
V
N
G
Q
I
I
Y
V
D
G
G
M
L
S
V
L
-----
110
PsiBlast_CBE
71.72
35%
-131
- C1 -
-
4BNX
1
FABG_PSEAE
D:
[22-266]
---------
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
--------
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
77
PsiBlast_CBE
71.21
35%
-129
- C1 -
-
4BO7
1
FABG_PSEAE
A:
[21-266]
--------
Q
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
-----------
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
106
PsiBlast_CBE
70.68
35%
-128
- C1 -
-
4BNY
1
FABG_PSEAE
D:
[21-266]
--------
Q
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
I
------
V
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
80
PsiBlast_CBE
70.67
35%
-138
- C1 -
-
4BO6
1
FABG_PSEAE
B:
[21-266]
--------
Q
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
I
T
----------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
-----
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
109
PsiBlast_CBE
70.66
35%
-127
- C1 -
-
4BNY
1
FABG_PSEAE
A:
[22-266]
---------
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
---------
R
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
93
PsiBlast_CBE
70.59
35%
-134
- C1 -
-
4BO2
1
FABG_PSEAE
C:
[21-266]
--------
Q
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
I
-----------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
94
PsiBlast_CBE
70.47
35%
-136
- C1 -
-
4BO2
1
FABG_PSEAE
B:
[24-266]
------------
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
I
-----------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
30
PsiBlast_CBE
70.36
41%
-111
- C1 -
-
3UF0
1
?
B:
[27-272]
----------
F
-
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
D
G
V
K
E
V
A
D
E
I
A
D
-
G
G
G
S
A
E
A
V
V
A
D
L
A
D
L
E
G
A
A
N
V
A
E
E
L
A
A
T
R
R
V
-
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
G
S
-
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
A
A
E
------
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
-------
117
PsiBlast_CBE
70.13
35%
-129
- C1 -
-
4BNV
1
FABG_PSEAE
D:
[21-266]
--------
Q
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
---------
M
K
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
A
M
G
N
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
97
PsiBlast_CBE
70.06
35%
-130
- C1 -
-
4BO1
1
FABG_PSEAE
A:
[21-266]
--------
Q
S
M
-
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
A
-
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
G
Q
P
L
I
V
V
N
N
A
G
-----------
D
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
-
G
R
I
I
N
I
G
S
V
V
G
----
A
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
--------
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
---------
8
PsiBlast_PDB
70.01
41%
-113
- C1 -
-
3UF0
1
?
A:
[27-272]
----------
F
-
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
D
G
V
K
E
V
A
D
E
I
A
D
-
G
G
G
S
A
E
A
V
V
A
D
L
A
D
L
E
G
A
A
N
V
A
E
E
L
A
A
T
R
R
V
-
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
G
S
-
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
A
A
E
------
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
-------
5
PsiBlast_PDB
69.86
45%
-70
- C1 -
-
4G81
1
?
D:
[5-255]
----------
F
-
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
-
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
------
F
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
V
L
-----
22
PsiBlast_CBE
69.19
45%
-66
- C1 -
-
4G81
1
?
B:
[5-255]
----------
F
-
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
-
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
------
F
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
V
L
-----
23
PsiBlast_CBE
68.90
45%
-69
- C1 -
-
4G81
1
?
A:
[5-255]
----------
F
-
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
-
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
------
F
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
V
L
-----
53
PsiBlast_CBE
55.17
35%
3
- C1 -
-
3RRO
5
FABG_VIBCH
B:
[5-248]
--------
S
Q
F
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
----
G
A
Q
A
I
S
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
-
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
--------
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
---------
54
PsiBlast_CBE
53.45
35%
5
- C1 -
-
3RRO
5
FABG_VIBCH
A:
[5-248]
--------
S
Q
F
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
G
T
A
T
S
E
S
----
G
A
Q
A
I
S
D
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
-
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
T
--------
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
---------