@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0304: (2017-12-19 )
MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNFAVIIGTGTRFGTDLAKEAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKILYVEKTQFNKVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITYANMMSIKKELEAAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSGMESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITEDFVWRDILYQSNYEPGSTMKVMMLAAAIDNNTFPGGEVFNSSELKIADATIRDWDVNEGLTGGRMMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLNRFKFGVPTRFGLTDEYAGQLPADNIVNIAQSSFGQGISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQIADEKNGGYLVGLTDYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQLGEFANPILERASAMKDSLNLQTTAKALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQPIVVGTGTKIKNSSAEEGKNLAPNQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEFQGSGSTVQKQDVRANTAIKDIKKITLTLGD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.....-..210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.....-.-.320--.......330.......340.......350.-......360........370.....-.-.380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480....-...490........500.......510.......520.......-530-----....------....540.......550.......560.......570.......580.......590..----.----....600......--.610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720--...-.-...730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
W
T
K
R
V
I
R
Y
A
TKNRKS
P
A
E
N
R
R
R
V
G
K
S
L
S
L
L
S
V
F
V
F
A
I
F
L
V
N
F
A
V
I
I
GTGTRF
G
T
D
L
A
K
E
A
K
K
V
H
Q
T
T
RTVPAKRG
T
I
YDRNGVPIAEDATSY
N
V
Y
A
V
I
DENYKSAT
G
K
I
L
Y
V
EKT
Q
F
N
K
V
A
E
V
F
H
K
Y
LD
M
E
E
S
Y
V
R
E
Q
LSQPN
L
K
Q
V
SFGAKGNG
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
A
AEVKG
I
D
FTTSPNRSYPN
G
Q
F
A
S
S
F
I
G
L
A
Q
L
HENE-DGSKSLLGTS
G
M
E
S
S
L
N
S
I
LAGTD
G
I
I
T
YEKDRLGNIVP
G
T
E
Q
V
S
Q
RTMDG
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
VKG
K
Y
M
T
A
T
L
V
SAKTG
E
I
L
A
TTQRPTFDADTKEG-I-
T
E
D
F
--
V
W
R
D
I
L
YQSNYEPGS
T
M
K
V
M
M
L
A
A
AIDNNTF-PGGEVFNS-SE
L
K
I
A
D
A
T
I
RDWDVN-E-GLTGG
R
M
M
T
F
SQGFAHSSNV
G
M
T
L
L
E
Q
KMG
D
A
T
W
L
D
Y
L
N
R
F
KFGVPTRFGL
T
D
E
YAGQLP
A
D
N
I
V
N
I
A
Q
S
SFGQGI
S
V
T
Q
T
Q
M
I
R
A
F
T
A
IAND
G
V
M
L
E
P
K
F
I
S
AIYDP-N
D
Q
T
A
-
R
K
S
Q
K
E
IVGNPVS
K
D
A
A
SLTRT
N
M
V
L
V
GTDP
V
Y
G
T
MYN-HS------TGK
P
------
T
V
T
VPGQ
N
V
A
LKSGT
A
Q
IADEKNG
G
Y
L
V
G
L
T
D
Y
I
F
S
A
VSMSPAENP
D
F
I
L
Y
V
T
VQQPEH----Y----SGIQ
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
DSL
N
L
Q
T
T
A
K
A
L
E
Q
V
SQQSPYPMPSVKDI
S
P
G
D
L
A
E
E
L
R
R
NLVQ
P
I
V
VGTGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
LSD
K
A
E
EV
P
D
M
YG
W
T
K
E
T
A
E
T
L
A
K
WL
N
I
E
L
E
FQG--SGS-T-
V
Q
K
QDVRAN
T
A
I
K
D
I
K
K
I
T
L
TLGD
4
PsiBlast_PDB
85.13
100%
-
- C1 -
-
1PMD
-
PBPX_STRPN
A:
[76-749]
---------------------------------------------------------------------------
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
N
Y
K
S
A
T
G
K
I
L
Y
V
E
K
T
Q
F
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
P
N
L
K
Q
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
A
A
E
V
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
Q
V
S
Q
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
Q
T
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
--
S
G
S
-
T
-
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
-
3
PsiBlast_PDB
84.24
96%
-48
- C1 -
-
1RP5
-
PBPX_STRPN
A:
[16-702]
---------------------------------------------------------------
K
V
H
Q
T
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
N
Y
K
S
A
T
G
K
I
L
Y
V
E
K
T
Q
F
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
P
N
L
K
Q
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
T
A
E
V
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
Q
V
S
Q
Q
T
V
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
M
S
A
F
G
Q
G
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
L
Y
D
P
-
N
D
Q
S
V
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
E
A
A
S
V
T
R
D
H
M
V
M
V
G
T
D
P
T
Y
G
T
M
Y
N
-
H
S
------
T
G
K
A
------
T
V
N
V
P
G
Q
N
V
A
L
K
S
G
T
A
E
I
A
D
E
K
N
G
G
Y
L
T
G
S
T
N
N
I
F
S
V
V
S
M
H
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
E
S
L
N
L
Q
T
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
F
A
K
W
L
N
I
E
L
E
F
E
G
--
S
G
S
-
T
-
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
K
L
T
L
G
D
2
PsiBlast_PDB
78.44
99%
-45
- C1 -
-
1PYY
2
PBPX_STRR6
A:
[25-702]
------------------------------------------------------------------------
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
---------------------
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
-------
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
------------------
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
-------------------------
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
A
F
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
Q
T
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
--
S
G
S
-
T
-
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
1
PsiBlast_PDB
77.25
100%
-42
- C1 -
-
1QME
-
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
---------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
Q
-----------
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
--
S
G
S
-
T
-
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
25
Fugue
77.16
99%
-42
- C1 -
-
1QME
-
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
---------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
-----------
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
--
S
G
S
-
T
-
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
27
Fugue
76.83
98%
-42
- C1 -
-
1QME
-
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
------------------------------------------------------------------------------------------
P
I
A
E
D
A
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
---------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
-----------
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
--
S
G
S
-
T
-
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
36
HHSearch
68.69
94%
21
- C1 -
-
1QME
-
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
---------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
G
L
T
G
G
R
M
M
-
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
------
T
-
D
P
V
Y
G
TMYNHS
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
-----------------
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
--
S
G
--
S
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
26
Fugue
66.70
86%
-37
- C1 -
-
1K25
-
?
A:
[67-750]
------------------------------------------------------------------
Q
I
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
---------------------------------------------------------------------------------
S
Y
N
V
Y
A
V
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
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S
F
I
G
L
A
Q
L
H
E
N
E
-
D
G
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K
S
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L
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T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
G
N
I
-----
V
P
G
T
E
L
V
S
Q
Q
T
V
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G
K
D
V
Y
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T
L
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A
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-
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--
V
W
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Y
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A
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F
-
P
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G
E
Y
F
N
S
-
S
E
--------------------------------
L
S
S
N
V
G
M
S
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
K
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
S
I
A
Q
S
S
F
G
Q
G
I
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V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
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P
K
F
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A
I
Y
D
T
-
N
N
Q
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V
-
R
K
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N
P
V
S
K
E
A
A
S
T
T
R
N
H
M
I
L
V
G
T
D
P
-------------------
L
------
I
I
T
V
P
G
Q
N
V
A
V
K
S
G
T
A
Q
I
A
D
E
K
N
G
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Y
L
V
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N
Y
I
F
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A
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T
M
N
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
T
P
I
L
--
E
R
A
S
A
M
K
E
S
L
N
L
Q
S
P
A
K
N
L
D
K
V
T
T
E
S
S
Y
A
M
P
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D
I
S
P
G
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L
A
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A
L
R
R
N
I
V
Q
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V
V
G
T
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K
I
K
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V
E
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G
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N
L
A
P
N
Q
Q
V
L
L
L
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D
K
V
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G
W
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A
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F
A
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W
L
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I
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L
E
F
E
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--
S
G
S
-
V
-
V
Q
K
Q
D
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R
T
N
T
A
I
K
N
I
K
K
I
K
L
T
L
G
D
9
PsiBlast_PDB
63.71
50%
32
- C1 -
-
5U47
-
?
A:
[24-707]
-------------------------------------------------------------------
T
K
T
I
V
A
A
K
R
G
T
I
Y
D
R
N
G
N
V
L
A
E
D
S
T
S
Y
S
I
Y
A
I
V
S
T
S
Y
V
S
P
T
R
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K
L
Y
V
Q
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S
Q
F
D
K
V
A
D
I
L
K
D
K
L
G
I
K
K
S
Y
T
L
A
Q
L
R
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K
G
A
Y
Q
V
S
F
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L
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K
G
I
T
Y
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L
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A
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A
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K
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L
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K
K
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Y
--
D
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-
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-
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-
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N
N
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N
-
K
S
------
E
G
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P
------
I
I
Q
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N
N
D
V
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A
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----
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----
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N
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--
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--
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A
A
G
E
A
L
S
K
T
K
K
I
T
I
T
L
G
D
35
HHSearch
61.58
49%
28
- C1 -
-
5U47
-
?
A:
[24-707]
-------------------------------------------------------------------
T
K
T
I
V
A
A
K
R
G
T
I
Y
D
R
N
G
N
V
L
A
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S
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A
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L
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S
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-
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N
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N
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A
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I
G
K
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V
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K
Q
A
A
S
E
T
R
N
Y
M
I
S
V
G
------
T
-
D
P
E
F
G
------
T
L
Y
N
KSEGSP
I
I
Q
V
G
N
N
D
V
T
V
K
S
G
T
A
Q
V
P
D
E
K
T
G
T
Y
K
V
G
T
N
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T
L
N
S
V
V
A
M
V
P
S
E
D
P
E
Y
I
M
Y
V
T
V
Q
E
P
K
T
WNNN
F
----
F
A
T
V
V
N
P
V
L
E
E
A
M
--
S
M
G
A
T
L
-
D
T
S
V
S
E
G
S
G
-----
K
T
E
E
T
S
Y
Q
T
G
D
I
I
G
K
T
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G
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T
A
N
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L
R
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L
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P
I
V
L
G
V
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K
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V
D
A
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A
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I
M
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N
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F
T
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L
P
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Y
G
W
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N
V
E
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A
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W
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I
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I
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Y
K
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--
T
-
V
T
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S
V
A
A
G
E
A
L
S
K
T
K
K
I
T
I
T
L
G
D
6
PsiBlast_PDB
60.39
100%
-58
- C1 -
-
2Z2M
1
?
B:
[14-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
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K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
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E
I
L
A
T
T
Q
R
P
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F
D
A
D
T
K
E
G
-
I
-
T
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D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
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P
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T
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M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
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L
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A
T
I
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N
-
E
-
G
L
T
G
G
R
M
M
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F
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A
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S
S
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L
L
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A
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T
N
M
V
L
V
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D
P
V
Y
G
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Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
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G
T
A
Q
I
A
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----
G
Y
L
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Y
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A
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N
P
D
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Y
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----
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----
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G
I
Q
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F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
--------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
60.15
100%
-58
- C1 -
-
2ZC3
1
?
E:
[14-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
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K
V
K
G
K
Y
M
T
A
T
L
V
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A
K
T
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E
I
L
A
T
T
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R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
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S
N
Y
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P
G
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T
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M
M
L
A
A
A
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N
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S
-
S
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K
I
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A
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N
-
E
-
G
L
T
G
G
R
M
M
T
F
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G
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A
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S
S
N
V
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M
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L
L
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M
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L
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Y
L
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F
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F
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A
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N
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M
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A
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F
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A
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N
D
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A
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M
V
L
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N
-
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------
T
G
K
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------
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V
T
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A
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T
A
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Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
--------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.03
100%
-55
- C1 -
-
2Z2L
-
?
B:
[14-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
--------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
59.98
100%
-60
- C1 -
-
2Z2M
1
?
E:
[14-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
-------
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
--------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
59.92
100%
-61
- C1 -
-
2ZC4
1
?
E:
[14-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
----
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
--------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.32
100%
-55
- C1 -
-
2ZC3
1
?
B:
[14-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
---------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.25
100%
-55
- C1 -
-
2ZC4
1
?
B:
[14-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
---------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
52.07
34%
-19
- C1 -
-
5TRO
-
?
B:
[26-554]
-----------------------------------------------------------------------
Q
Q
P
E
R
G
K
I
Y
D
R
N
G
K
V
L
A
E
D
V
E
R
Y
K
L
V
A
V
I
D
K
K
A
S
A
N
S
K
K
P
R
H
V
V
--
D
K
K
E
T
A
K
K
L
S
T
V
I
N
M
K
P
E
E
I
E
K
R
L
S
Q
K
K
A
F
Q
I
E
F
G
R
K
G
T
N
L
T
Y
Q
D
K
L
K
I
----
E
K
M
N
L
P
G
I
S
L
L
P
E
T
E
R
F
Y
P
N
G
N
F
A
S
H
L
I
G
R
A
Q
K
N
P
D
----
T
G
E
L
K
G
A
L
G
V
E
K
I
F
D
S
Y
L
S
G
S
K
------------------------
K
R
G
D
D
V
H
L
T
I
D
S
N
I
Q
V
F
V
E
E
A
L
D
G
M
V
E
R
Y
Q
P
K
D
L
F
A
V
V
M
D
A
K
T
G
E
I
L
A
Y
S
Q
R
P
T
F
N
P
E
T
G
K
D
-
F
-
G
--
K
--
K
W
A
N
D
L
Y
Q
N
T
Y
E
P
G
S
T
F
K
S
Y
G
L
A
A
A
I
Q
E
G
A
F
-
D
P
D
K
K
Y
K
S
-
G
H
R
D
I
M
G
S
R
I
S
D
--
W
N
---
R
V
G
W
G
E
I
-
P
M
S
L
G
F
T
Y
S
S
N
T
L
M
M
H
L
Q
D
L
V
G
A
D
K
M
K
S
W
Y
E
R
F
G
F
G
K
S
T
K
G
M
F
D
G
E
A
P
G
Q
I
G
W
S
N
E
L
Q
Q
K
T
S
S
F
G
Q
S
T
T
V
T
P
V
Q
M
L
Q
A
Q
S
A
F
F
N
D
G
N
M
L
K
P
W
F
V
N
S
V
E
N
P
-
V
S
K
R
Q
F
Y
K
G
Q
K
Q
I
A
G
K
P
I
T
K
D
T
A
E
K
V
E
K
Q
L
D
L
V
V
------
N
-
S
K
-
K
S
------
H
A
-
A
------
N
Y
R
I
D
G
Y
E
V
E
G
K
T
G
T
A
Q
V
A
A
P
N
G
G
G
Y
V
K
G
P
N
P
Y
F
V
S
F
M
G
D
A
P
K
K
N
P
K
V
I
V
Y
A
G
M
S
L
A
Q
K
N
D
Q
E
A
----
Y
E
L
G
V
S
K
A
F
K
P
I
M
--
E
N
T
L
K
Y
L
N
V
G
K
---------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
49.60
100%
0
- C- -
-
1QME
-
PBPX_STRPN
A:
[216-583]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
-
I
-
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
-
P
G
G
E
V
F
N
S
-
S
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-
E
-
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
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Y
A
G
Q
L
P
A
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N
I
V
N
I
A
Q
S
S
F
G
Q
G
I
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V
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Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
-
N
D
Q
T
A
-
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
N
-
H
S
------
T
G
K
P
------
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
H
----
Y
----
S
G
I
Q
L
G
E
F
A
N
P
I
L
--
E
R
A
S
A
M
K
D
S
L
N
L
--------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.69
34%
18
- C1 -
-
5TRO
-
?
A:
[26-518]
-----------------------------------------------------------------------
Q
Q
P
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R
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-------------------------
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-----
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-
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A
------
A
---------
N
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Y
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------