@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0328: (2017-12-20 )
MNKGLFEKRCKYSIRKFSLGVASVMIGATFFGTSPVLADSVQSGSTANLPADLATALATAKENDGHDFEAPKVGEDQGSPEVTDGPKTEEELLALEKEKPAEEKPKEDKPAAAKPETPKTVTPEWQTVEKKEQQGTVTIREEKGVRYNQLSSTAQNDNAGKPALFEKKGLTVDANGNATVDLTFKDDSEKGKSRFGVFLKFKDTKNNVFVGYDKDGWFWEYKSPTTSTWYRGSRVAAPETGSTNRLSITLKSDGQLNASNNDVNLFDTVTLPAAVNDHLKNEKKILLKAGSYDDERTVVSVKTDNQEGVKTEDTPAEKETGPEVDDSKVTYDTIQSKVLKAVIDQAFPRVKEYSLNGHTLPGQVQQFNQVFINNHRITPEVTYKKINETTAEYLMKLRDDAHLINAEMTVRLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERKLLSSISFLGNALVSVSSDQTGAKFDGATMSNNTHVSGDDHIDVTNPMKDLAKGYMYGFVSTDKLAAGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKELPSAKVVITEDANADKKVDWQDGAIAYRSIMNNPQGWKKVKDITAYRIAMNFGSQAQNPFLMTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIEKAKKYGAHLGIHVNASETYPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDAAYDLAHGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGDNGAWATHVLAKEINKQGWRFAIEWGHGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLLGGYSMKDFEGWQGRSDYNGYVTNLFAHDVMTKYFQHFTVSKWENGTPVTMTDNGSTYKWTPEMRVELVDADNNKVVVTRKSNDVNSPQYRERTVTLNGRVIQDGSAYLTPWNWDANGKKLSTDKEKMYYFNTQAGATTWTLPSDWAKSKVYLYKLTDQGKTEEQELTVKDGKITLDLLANQPYVLYRSKQTNPEMSWSEGMHIYDQGFNSGTLKHWTISGDASKAEIVKSQGANDMLRIQGNKEKVSLTQKLTGLKPNTKYAVYVGVDNRSNAKASITVNTGEKEVTTYTNKSLALNYVKAYAHNTRRNNATVDDTSYFQNMYAFFTTGSDVSNVTLTLSREAGDEATYFDEIRTFENNSSMYGDKHDTGKGTFKQDFENVAQGIFPFVVGGVEGVEDNRTHLSEKHDPYTQRGWNGKKVDDVIEGNWSLKTNGLVSRRNLVYQTIPQNFRFEAGKTYRVTFEYEAGSDNTYAFVVGKGEFQSGRRGTQASNLEMHELPNTWTDSKKAKKATFLVTGAETGDTWVGIYSTGNASNTRGDSGGNANFRGYNDFMMDNLQIEEITLTGKMLTENALKNYLPTVAMTNYTKESMDALKEAVFNLSQADDDISVEEARAEIAKIEALKNALVQKKTALVADDFASLTAPAQAQEGLANAFDGNLSSLWHTSWGGGDVGKPATMVLKEATEITGLRYVPRGSGSNGNLRDVKLVVTDESGKEHTFTATDWPDNNKPKDIDFGKTIKAKKIVLTGTKTYGDGGDKYQSAAELIFTRPQVAETPLDLSGYEAALAKAQKLTDKDNQEEVASVQASMKYATDNHLLTERMVEYFADYLNQLKDSATKPDAPTVEKPEFKLSSVASDQGKTPDYKQEIARPETPEQILPATGESQFDTALFLASVSLALSALFVVKTKKD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350...-....360.......370......---.380.......390.......400.......410.......420.......--430.......440.......450.......460.......470.......480.......490.......-500.......510...------...--------.520----..------.......530.......540.......550...---..---..560.......570.......580.......590.......600-------.......610....----------.----..-620-........630....--...640....-..-.650.......660.......670.......680.......690.......700.......710.......720.....-.-.730.......740-..-.....750.......760.....-.-.-----------770........780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......-----910------....-...-----920.......930.......940.......950......-------.960----------.------------.-----.......970.-.......980........990.......1000.-.-.....1010......1020......1030......1040......1050......1060.....---.1070......1080......1090.......1100......1110......1120......1130.....-.1140..-.....1150......1160......1170......1180......1190......1200..-......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410.....---------------.1420-..----.....1430....----..1440......1450......--1460........1470......1480......1490......1500....---..1510......1520....--.-.1530......1540......1550......1560......1570......-------1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNK
G
L
F
E
K
R
C
K
Y
S
I
R
K
FS
L
G
V
A
S
V
M
I
G
A
T
FFGTSP
V
L
A
D
SVQSGSTANL
P
A
D
L
A
T
A
L
A
TAKENDGHDFEAPKVGEDQGSPEVTDGPK
T
E
E
E
L
L
A
L
EKEKPAEEKPKEDKPAAAKPETPKTVTPE
W
Q
T
V
E
K
KEQQG
T
V
T
I
R
EEKG
V
R
YNQLSSTAQNDNAGKPA
L
F
EKKG
L
T
VDANG
N
A
T
V
D
L
T
FKDDSEKGKSR
F
G
V
F
L
K
F
KDTKN
N
V
F
V
G
YDKD
G
W
F
W
E
YKSPTTSTWYRGSRVAAPETGST
N
R
L
S
I
T
LKSD
G
Q
LNASNN
D
V
N
L
F
D
TVTL
P
A
A
V
N
D
HLKNE
K
K
I
L
L
KAGSYDDE
R
T
V
V
S
V
KTDNQEGVKTEDTPAEKETGPEVDDSK
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
AF
P
R
V
K
EYSL-NGHTL
P
G
Q
V
Q
Q
F
N
Q
V
F
INNHRI
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
LRDD
A
H
L
I
NA
E
M
T
V
R
L
Q
V
VDNQLH
F
D
V
T
K
IVNH--NQVTPGQKI
D
D
E
R
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
VSSDQTGAKFD
G
A
TMSNNTHVSGDDHIDVT
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
FV
S
T
D
K
L
A
AGVWSNS------QNS--------YG------GG------SND
W
T
R
L
T
A
Y
K
E
TVGNA
N
Y
V
G
IHSSE
W
Q
W
E
K
A
Y---KG---IVF
P
E
Y
T
K
ELPS
A
K
V
V
I
TEDANADKKVDWQD
G
A
I
A
Y
R
S
I
MNN
P
Q
G
-------
W
K
K
V
K
D
I
T
A
Y
R
I
A
M----------N----FG-SQ--AQN
P
F
L
M
T
LD
G
I
K
K
I
--
N
L
HTDGLGQ
G
-
V
L
-
L
K
GYGSEGHDSGHL
N
Y
A
D
I
G
K
RIG
G
V
E
D
F
K
T
L
I
E
K
A
K
KYG
A
H
L
G
I
H
VNASETYPESKY
F
N
E
K
I
LRKNPDGSYSY
G
W
N
W
L
-D-QGINI
D
A
A
YDLAHG-R
L
-
A
R
W
E
D
L
K
K
K
LGDGL
D
F
I
Y
V
D
V
WG-N-G-----------Q-SGDN
G
A
W
A
T
H
V
L
A
K
E
INKQG
W
R
F
A
I
EWGHGGEYDS
T
F
H
H
WAADLTYGGYTNKG
I
N
S
A
I
T
R
F
I
R
NHQKDAWVGDYRSYGGAANYPLLGGYSMKDFEGWQGRSDYN
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
FTVSKWENGT
P
V
T
MTDN-----G
S
T
------
Y
K
WT-P
E
M
-----
R
V
E
L
V
DADN
N
K
V
V
V
T
RKSNDVNSPQ
Y
R
E
R
T
V
T
LN
G
R
V
IQ-------DG------------S------------
A
-----
Y
LTPWNWD-AN-GKKLSTDK
E
-
K
M
Y
Y
F
NTQAG
A
T
T
WTLPSDWA-K-
S
-
K
V
Y
L
Y
K
LTDQGKTEE
Q
E
L
T
VKD
G
K
I
T
L
D
LLANQ
P
Y
V
L
Y
RSKQTNPEMSWSEG
M
H
I
YDQGFNSG
T
---
L
K
H
W
T
ISGDA
S
K
A
E
I
V
KSQGAN
D
-
M
L
R
IQGNK
E
K
V
S
L
T
Q
K
L
TGLKPNT
K
Y
A
V
Y
V
G
VDNRSN
A
K
A
S
I
T
V
NTG-E
K
E
-
V
T
T
-YTN
K
S
L
A
L
N
Y
V
K
A
Y
A
HNTRRNNATVD
D
T
S
Y
F
Q
N
M
Y
A
F
F
TTGSDV
S
N
V
T
L
T
L
SREAG-D-E
A
-
T
Y
F
D
E
I
R
TFENNSSMYGDKHDTGKG
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
VGGVEGVEDNRTHLSEKHDPYTQRGWNGK
K
V
D
D
V
IEGN
W
S
L
KTNGLVSRR
N
L
V
Y
Q
TIPQNFRFEAG
K
T
Y
R
V
T
F
E
Y
EAGSD
N
T
Y
A
F
V
V
GKGEFQSGRRGTQASNL
E
M
HELPNTWTDSKKA
K
K
A
T
F
L
V
T
GAETG
D
T
W
V
G
I
Y
STGNASNTRGDSGGNANFRGYNDFMMDN
L
Q
I
E
E
I
---------------
T
LT
G
--
K
M
----
L
T
E
N
A
L
K
N
YLPTV----AMTNY
T
K
E
S
M
D
A
L
K
E
A
V
F
NLSQ--AD--DDI
S
V
E
E
A
R
A
E
I
A
K
I
E
A
L
K
N
A
L
V
Q
K
K
T
A
L
V
A
D
D
F
A
SLTA
P
A
Q
A
Q
E
G
---
L
A
N
AFDG
N
L
S
S
L
WHTSWGGG--D-VGK
P
A
T
M
V
L
K
E
ATEIT
G
L
R
Y
VPRGSGSNG
N
L
R
D
V
K
L
V
V
TDESGKE
H
T
F
TAT-------DWPDNNKPKDIDFGKT
I
K
A
K
K
I
V
L
TGTKTYGDG
G
D
K
Y
Q
S
A
A
E
L
IFTRPQVAETPLDLS
G
Y
E
A
A
L
A
K
A
Q
KLTDKD
N
Q
E
E
V
A
S
V
Q
A
S
M
K
YATDN
H
L
L
T
E
R
M
V
E
Y
F
A
D
Y
L
N
Q
L
K
DSATKPDAPTVEKPEF
K
L
S
S
VASDQGKT
P
D
Y
K
Q
E
IARPET
P
E
Q
ILPATGES
Q
F
D
T
A
L
F
L
A
S
V
S
L
A
L
S
A
L
F
V
V
KTKKD
42
HHSearch
74.02
100%
-26
- C1 -
-
5A57
24
GH101_STRPN
A:
[4-1112]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
D
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
E
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
-
K
V
Y
L
Y
K
L
T
D
Q
G
K
T
E
E
Q
E
L
T
V
K
D
G
K
I
T
L
D
L
L
A
N
Q
P
Y
V
L
Y
R
S
K
Q
T
N
P
E
M
S
W
S
E
G
M
H
I
Y
D
Q
G
F
N
S
G
T
---
L
K
H
W
T
I
S
G
D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
G
N
K
E
K
V
S
L
T
Q
K
L
T
G
L
K
P
N
T
K
Y
A
V
Y
V
G
V
D
N
R
S
N
A
K
A
S
I
T
V
N
T
G
-
E
K
E
-
V
T
T
-
Y
T
N
K
S
L
A
L
N
Y
V
K
A
Y
A
H
N
T
R
R
N
N
A
T
V
D
D
T
S
Y
F
Q
N
M
Y
A
F
F
T
T
G
A
D
V
S
N
V
T
L
T
L
S
R
E
A
G
-
D
-
E
A
-
T
Y
F
D
E
I
R
T
F
E
N
N
S
S
M
Y
G
D
K
H
D
T
G
K
G
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
V
G
G
V
E
G
V
E
D
N
R
T
H
L
S
E
K
H
D
P
Y
T
Q
R
G
W
N
G
K
K
V
D
D
V
I
E
G
N
W
S
L
K
T
N
G
L
V
S
R
R
N
L
V
Y
Q
T
I
P
Q
N
F
R
F
E
A
G
K
T
Y
R
V
T
F
E
Y
E
A
G
S
D
N
T
Y
A
F
V
V
G
K
G
E
F
Q
S
-----
Q
A
S
N
L
E
M
H
E
L
P
N
T
W
T
D
S
K
K
A
K
K
A
T
F
L
V
T
G
A
E
T
G
D
T
W
V
G
I
Y
S
T
G
N
A
S
N
T
R
G
D
S
G
G
N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
---------------
T
L
T
G
--
K
M
----
L
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.01
99%
-25
- C1 -
-
5A59
22
GH101_STRPN
A:
[2-1111]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
D
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
Q
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
-
K
V
Y
L
Y
K
L
T
D
Q
G
K
T
E
E
Q
E
L
T
V
K
D
G
K
I
T
L
D
L
L
A
N
Q
P
Y
V
L
Y
R
S
K
Q
T
N
P
E
M
S
W
S
E
G
M
H
I
Y
D
Q
G
F
N
S
G
T
---
L
K
H
W
T
I
S
G
D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
G
N
K
E
K
V
S
L
T
Q
K
L
T
G
L
K
P
N
T
K
Y
A
V
Y
V
G
V
D
N
R
S
N
A
K
A
S
I
T
V
N
T
G
-
E
K
E
-
V
T
T
-
Y
T
N
K
S
L
A
L
N
Y
V
K
A
Y
A
H
N
T
R
R
N
N
A
T
V
D
D
T
S
Y
F
Q
N
M
Y
A
F
F
T
T
G
A
D
V
S
N
V
T
L
T
L
S
R
E
A
G
-
D
-
E
A
-
T
Y
F
D
E
I
R
T
F
E
N
N
S
S
M
Y
G
D
K
H
D
T
G
K
G
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
V
G
G
V
E
G
V
E
D
N
R
T
H
L
S
E
K
H
D
P
Y
T
Q
R
G
W
N
G
K
K
V
D
D
V
I
E
G
N
W
S
L
K
T
N
G
L
V
S
R
R
N
L
V
Y
Q
T
I
P
Q
N
F
R
F
E
A
G
K
T
Y
R
V
T
F
E
Y
E
A
G
S
D
N
T
Y
A
F
V
V
G
K
G
E
F
Q
S
-----
Q
A
S
N
L
E
M
H
E
L
P
N
T
W
T
D
S
K
K
A
K
K
A
T
F
L
V
T
G
A
E
T
G
D
T
W
V
G
I
Y
S
T
G
N
A
S
N
T
R
G
D
S
G
G
N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
---------------
T
L
T
G
--
K
M
----
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.96
99%
-25
- C1 -
-
5A56
22
GH101_STRPN
A:
[2-1111]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
D
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
E
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
-
K
V
Y
L
Y
K
L
T
D
Q
G
K
T
E
E
Q
E
L
T
V
K
D
G
K
I
T
L
D
L
L
A
N
Q
P
Y
V
L
Y
R
S
K
Q
T
N
P
E
M
S
W
S
E
G
M
H
I
Y
D
Q
G
F
N
S
G
T
---
L
K
H
W
T
I
S
G
D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
G
N
K
E
K
V
S
L
T
Q
K
L
T
G
L
K
P
N
T
K
Y
A
V
Y
V
G
V
D
N
R
S
N
A
K
A
S
I
T
V
N
T
G
-
E
K
E
-
V
T
T
-
Y
T
N
K
S
L
A
L
N
Y
V
K
A
Y
A
H
N
T
R
R
N
N
A
T
V
D
D
T
S
Y
F
Q
N
M
Y
A
F
F
T
T
G
A
D
V
S
N
V
T
L
T
L
S
R
E
A
G
-
D
-
E
A
-
T
Y
F
D
E
I
R
T
F
E
N
N
S
S
M
Y
G
D
K
H
D
T
G
K
G
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
V
G
G
V
E
G
V
E
D
N
R
T
H
L
S
E
K
H
D
P
Y
T
Q
R
G
W
N
G
K
K
V
D
D
V
I
E
G
N
W
S
L
K
T
N
G
L
V
S
R
R
N
L
V
Y
Q
T
I
P
Q
N
F
R
F
E
A
G
K
T
Y
R
V
T
F
E
Y
E
A
G
S
D
N
T
Y
A
F
V
V
G
K
G
E
F
Q
S
-----
Q
A
S
N
L
E
M
H
E
L
P
N
T
W
T
D
S
K
K
A
K
K
A
T
F
L
V
T
G
A
E
T
G
D
T
W
V
G
I
Y
S
T
G
N
A
S
N
T
R
G
D
S
G
G
N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
---------------
T
L
T
G
--
K
M
----
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.85
99%
-25
- C1 -
-
5A57
24
GH101_STRPN
A:
[2-1112]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
D
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
E
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
-
K
V
Y
L
Y
K
L
T
D
Q
G
K
T
E
E
Q
E
L
T
V
K
D
G
K
I
T
L
D
L
L
A
N
Q
P
Y
V
L
Y
R
S
K
Q
T
N
P
E
M
S
W
S
E
G
M
H
I
Y
D
Q
G
F
N
S
G
T
---
L
K
H
W
T
I
S
G
D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
G
N
K
E
K
V
S
L
T
Q
K
L
T
G
L
K
P
N
T
K
Y
A
V
Y
V
G
V
D
N
R
S
N
A
K
A
S
I
T
V
N
T
G
-
E
K
E
-
V
T
T
-
Y
T
N
K
S
L
A
L
N
Y
V
K
A
Y
A
H
N
T
R
R
N
N
A
T
V
D
D
T
S
Y
F
Q
N
M
Y
A
F
F
T
T
G
A
D
V
S
N
V
T
L
T
L
S
R
E
A
G
-
D
-
E
A
-
T
Y
F
D
E
I
R
T
F
E
N
N
S
S
M
Y
G
D
K
H
D
T
G
K
G
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
V
G
G
V
E
G
V
E
D
N
R
T
H
L
S
E
K
H
D
P
Y
T
Q
R
G
W
N
G
K
K
V
D
D
V
I
E
G
N
W
S
L
K
T
N
G
L
V
S
R
R
N
L
V
Y
Q
T
I
P
Q
N
F
R
F
E
A
G
K
T
Y
R
V
T
F
E
Y
E
A
G
S
D
N
T
Y
A
F
V
V
G
K
G
E
F
Q
S
-----
Q
A
S
N
L
E
M
H
E
L
P
N
T
W
T
D
S
K
K
A
K
K
A
T
F
L
V
T
G
A
E
T
G
D
T
W
V
G
I
Y
S
T
G
N
A
S
N
T
R
G
D
S
G
G
N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
---------------
T
L
T
G
--
K
M
----
L
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.82
99%
-25
- C1 -
-
5A5A
22
GH101_STRPN
A:
[2-1111]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
D
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
Q
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
-
K
V
Y
L
Y
K
L
T
D
Q
G
K
T
E
E
Q
E
L
T
V
K
D
G
K
I
T
L
D
L
L
A
N
Q
P
Y
V
L
Y
R
S
K
Q
T
N
P
E
M
S
W
S
E
G
M
H
I
Y
D
Q
G
F
N
S
G
T
---
L
K
H
W
T
I
S
G
D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
G
N
K
E
K
V
S
L
T
Q
K
L
T
G
L
K
P
N
T
K
Y
A
V
Y
V
G
V
D
N
R
S
N
A
K
A
S
I
T
V
N
T
G
-
E
K
E
-
V
T
T
-
Y
T
N
K
S
L
A
L
N
Y
V
K
A
Y
A
H
N
T
R
R
N
N
A
T
V
D
D
T
S
Y
F
Q
N
M
Y
A
F
F
T
T
G
A
D
V
S
N
V
T
L
T
L
S
R
E
A
G
-
D
-
E
A
-
T
Y
F
D
E
I
R
T
F
E
N
N
S
S
M
Y
G
D
K
H
D
T
G
K
G
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
V
G
G
V
E
G
V
E
D
N
R
T
H
L
S
E
K
H
D
P
Y
T
Q
R
G
W
N
G
K
K
V
D
D
V
I
E
G
N
W
S
L
K
T
N
G
L
V
S
R
R
N
L
V
Y
Q
T
I
P
Q
N
F
R
F
E
A
G
K
T
Y
R
V
T
F
E
Y
E
A
G
S
D
N
T
Y
A
F
V
V
G
K
G
E
F
Q
S
-----
Q
A
S
N
L
E
M
H
E
L
P
N
T
W
T
D
S
K
K
A
K
K
A
T
F
L
V
T
G
A
E
T
G
D
T
W
V
G
I
Y
S
T
G
N
A
S
N
T
R
G
D
S
G
G
N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
---------------
T
L
T
G
--
K
M
----
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.79
99%
-26
- C1 -
-
5A58
22
GH101_STRPN
A:
[2-1111]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
N
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
E
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
-
K
V
Y
L
Y
K
L
T
D
Q
G
K
T
E
E
Q
E
L
T
V
K
D
G
K
I
T
L
D
L
L
A
N
Q
P
Y
V
L
Y
R
S
K
Q
T
N
P
E
M
S
W
S
E
G
M
H
I
Y
D
Q
G
F
N
S
G
T
---
L
K
H
W
T
I
S
G
D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
G
N
K
E
K
V
S
L
T
Q
K
L
T
G
L
K
P
N
T
K
Y
A
V
Y
V
G
V
D
N
R
S
N
A
K
A
S
I
T
V
N
T
G
-
E
K
E
-
V
T
T
-
Y
T
N
K
S
L
A
L
N
Y
V
K
A
Y
A
H
N
T
R
R
N
N
A
T
V
D
D
T
S
Y
F
Q
N
M
Y
A
F
F
T
T
G
A
D
V
S
N
V
T
L
T
L
S
R
E
A
G
-
D
-
E
A
-
T
Y
F
D
E
I
R
T
F
E
N
N
S
S
M
Y
G
D
K
H
D
T
G
K
G
T
F
K
Q
D
F
E
N
V
A
Q
G
I
F
P
F
V
V
G
G
V
E
G
V
E
D
N
R
T
H
L
S
E
K
H
D
P
Y
T
Q
R
G
W
N
G
K
K
V
D
D
V
I
E
G
N
W
S
L
K
T
N
G
L
V
S
R
R
N
L
V
Y
Q
T
I
P
Q
N
F
R
F
E
A
G
K
T
Y
R
V
T
F
E
Y
E
A
G
S
D
N
T
Y
A
F
V
V
G
K
G
E
F
Q
S
-----
Q
A
S
N
L
E
M
H
E
L
P
N
T
W
T
D
S
K
K
A
K
K
A
T
F
L
V
T
G
A
E
T
G
D
T
W
V
G
I
Y
S
T
G
N
A
S
N
T
R
G
D
S
G
G
N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
---------------
T
L
T
G
--
K
M
----
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.76
99%
-23
- C1 -
-
5A55
2
GH101_STRPN
A:
[4-1105]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
T
G
P
E
V
D
D
S
K
V
T
Y
D
T
I
Q
S
K
V
L
K
A
V
I
D
Q
A
F
P
R
V
K
E
Y
S
L
-
N
G
H
T
L
P
G
Q
V
Q
Q
F
N
Q
V
F
I
N
N
H
R
I
T
---
P
E
V
T
Y
K
K
I
N
E
T
T
A
E
Y
L
M
K
L
R
D
D
A
H
L
I
N
A
E
M
T
V
R
L
Q
V
V
D
N
Q
L
H
F
D
V
T
K
I
V
N
H
--
N
Q
V
T
P
G
Q
K
I
D
D
E
S
K
L
L
S
S
I
S
F
L
G
N
A
L
V
S
V
S
S
D
Q
T
G
A
K
F
D
G
A
T
M
S
N
N
T
H
V
S
G
D
D
H
I
D
V
T
N
P
M
K
D
L
A
K
G
Y
M
Y
-
G
F
V
S
T
D
K
L
A
A
G
V
W
S
N
S
------
Q
N
S
--------
Y
G
------
G
G
------
S
N
D
W
T
R
L
T
A
Y
K
E
T
V
G
N
A
N
Y
V
G
I
H
S
S
E
W
Q
W
E
K
A
Y
---
K
G
---
I
V
F
P
E
Y
T
K
E
L
P
S
A
K
V
V
I
T
E
D
A
N
A
D
K
N
V
D
W
Q
D
G
A
I
A
Y
R
S
I
M
N
N
P
Q
G
-------
W
E
K
V
K
D
I
T
A
Y
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
M
T
L
D
G
I
K
K
I
--
N
L
H
T
D
G
L
G
Q
G
-
V
L
-
L
K
G
Y
G
S
E
G
H
D
S
G
H
L
N
Y
A
D
I
G
K
R
I
G
G
V
E
D
F
K
T
L
I
E
K
A
K
K
Y
G
A
H
L
G
I
H
V
N
A
S
E
T
Y
P
E
S
K
Y
F
N
E
K
I
L
R
K
N
P
D
G
S
Y
S
Y
G
W
N
W
L
-
D
-
Q
G
I
N
I
D
A
A
Y
D
L
A
H
G
-
R
L
-
A
R
W
E
D
L
K
K
K
L
G
D
G
L
D
F
I
Y
V
D
V
W
G
-
N
-
G
-----------
Q
-
S
G
D
N
G
A
W
A
T
H
V
L
A
K
E
I
N
K
Q
G
W
R
F
A
I
E
W
G
H
G
G
E
Y
D
S
T
F
H
H
W
A
A
D
L
T
Y
G
G
Y
T
N
K
G
I
N
S
A
I
T
R
F
I
R
N
H
Q
K
D
A
W
V
G
D
Y
R
S
Y
G
G
A
A
N
Y
P
L
L
G
G
Y
S
M
K
D
F
E
G
W
Q
G
R
S
D
Y
N
G
Y
V
T
N
L
F
A
H
D
V
M
T
K
Y
F
Q
H
F
T
V
S
K
W
E
N
G
T
P
V
T
M
T
D
N
-----
G
S
T
------
Y
K
W
T
-
P
E
M
-----
R
V
E
L
V
D
A
D
N
N
K
V
V
V
T
R
K
S
N
D
V
N
S
P
Q
Y
R
E
R
T
V
T
L
N
G
R
V
I
Q
-------
D
G
------------
S
------------
A
-----
Y
L
T
P
W
N
W
D
-
A
N
-
G
K
K
L
S
T
D
K
E
-
K
M
Y
Y
F
N
T
Q
A
G
A
T
T
W
T
L
P
S
D
W
A
-
K
-
S
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K
V
Y
L
Y
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E
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G
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L
L
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Y
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M
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Q
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F
N
S
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---
L
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H
W
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D
A
S
K
A
E
I
V
K
S
Q
G
A
N
D
-
M
L
R
I
Q
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N
K
E
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L
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L
T
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L
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P
N
T
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Y
A
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Y
V
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-
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Y
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L
A
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R
N
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A
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D
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Y
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A
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V
T
L
T
L
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R
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A
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-
D
-
E
A
-
T
Y
F
D
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R
T
F
E
N
N
S
S
M
Y
G
D
K
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D
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G
K
G
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K
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A
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G
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G
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T
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G
W
N
G
K
K
V
D
D
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W
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L
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V
V
G
K
G
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F
Q
S
-----
Q
A
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N
L
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M
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K
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A
K
K
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A
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N
A
N
F
R
G
Y
N
D
F
M
M
D
N
L
Q
I
E
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
55.39
47%
69
- C1 -
-
2ZXQ
3
?
A:
[23-1206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
E
T
L
K
T
K
K
M
E
V
Q
I
K
K
N
F
P
S
V
L
Q
Y
T
M
T
D
G
K
V
M
Y
G
Q
S
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D
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N
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T
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L
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D
D
D
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K
K
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A
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Y
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D
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A
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A
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I
T
V
Q
I
T
V
K
A
N
Q
L
H
L
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T
K
I
K
N
N
--
L
S
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I
P
E
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N
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Q
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L
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T
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D
Y
T
Y
-
G
F
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S
G
A
G
L
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A
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L
W
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N
S
EHDGTY
V
A
A
--------
P
V
------
R
G
------
G
S
Q
N
T
R
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Y
A
T
T
Q
Q
T
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A
T
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L
G
L
A
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Y
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---
K
K
Y
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A
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P
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A
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E
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-------
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----------
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----
F
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-
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--
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L
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T
-----------
S
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D
Y
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Y
G
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A
A
N
A
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L
L
G
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Y
N
M
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D
F
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W
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G
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N
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Y
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A
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N
L
Y
T
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T
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F
I
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H
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K
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T
R
W
V
N
N
P
L
L
T
A
D
N
G
NAAAV
S
D
P
------
N
T
N
N
-
G
N
E
-----
Q
I
T
L
K
D
S
N
G
N
V
V
V
V
S
R
G
S
N
D
T
S
S
A
A
Y
R
Q
R
T
I
T
F
N
G
V
K
V
A
-------
S
G
------------
V
V
SAGDGSATGDE
S
-----
Y
L
L
P
W
M
W
D
S
F
T
-
G
K
L
V
K
D
S
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Q
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Y
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A
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Y
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A
K
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A
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N
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W
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V
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G
S
G
---
K
A
E
V
E
G
D
N
N
A
-
M
L
R
L
T
G
---
K
V
D
V
S
Q
R
L
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D
L
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A
G
Q
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Y
A
L
Y
V
G
V
D
N
R
S
T
G
D
A
S
V
T
V
T
S
G
G
K
V
L
-
A
T
N
-
S
T
G
K
S
I
A
K
N
Y
I
K
A
Y
G
H
N
T
--
N
S
N
T
E
N
G
S
S
Y
F
Q
N
M
Y
V
F
F
T
A
P
E
N
-
G
D
A
T
V
T
L
S
H
K
S
T
-
D
G
A
H
-
T
Y
F
D
D
V
R
I
V
E
N
Q
Y
S
G
I
T
Y
E
K
D
G
T
L
K
S
L
T
N
G
F
E
N
N
A
Q
G
I
W
P
F
V
V
S
G
S
E
G
V
E
D
N
R
I
H
L
S
E
L
H
A
P
F
T
R
A
G
W
D
V
K
K
M
D
D
V
L
D
G
T
W
S
V
K
V
N
G
L
T
Q
K
G
T
L
V
Y
Q
T
I
P
Q
N
V
K
F
E
A
G
A
K
Y
K
V
S
F
D
Y
Q
S
G
S
D
D
I
Y
A
I
A
V
G
Q
G
E
Y
S
A
G
S
V
K
L
T
N
L
K
----------
K
A
L
G
E
T
G
K
A
E
F
E
L
T
G
G
V
N
G
D
S
W
F
G
I
Y
S
T
A
T
A
P
D
L
Q
G
S
T
G
N
A
Q
D
F
G
G
Y
K
D
F
V
L
D
N
L
K
I
E
R
I
---------------
E
S
Q
T
--
R
------
T
K
A
E
A
Q
D
K
V
K
E
I
----
R
G
K
Y
D
S
K
R
A
W
Q
Q
Y
Q
D
T
L
V
K
A
R
V
L
I
N
K
--
N
G
A
T
A
E
D
F
T
K
A
Y
D
I
L
V
A
L
D
E
Y
M
K
T
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
54.74
45%
68
* C1 *
-
2ZXQ
3
?
A:
[23-1206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
E
T
L
K
T
K
K
M
E
V
Q
I
K
K
N
F
P
S
V
L
Q
Y
T
M
T
D
G
K
V
M
Y
G
Q
S
K
D
V
R
T
V
E
I
N
G
T
N
I
E
L
G
D
D
D
V
T
F
K
K
V
S
D
T
E
A
T
Y
T
L
K
V
K
D
E
A
K
K
I
D
A
V
I
T
V
Q
I
T
V
K
A
N
Q
L
H
L
N
V
T
K
I
K
N
N
--
L
S
E
G
I
P
E
G
N
G
V
E
E
N
A
I
Q
T
L
S
F
P
N
Q
S
L
V
S
V
R
S
S
Q
E
N
A
Q
F
T
G
A
R
M
S
S
N
T
Q
K
P
G
D
T
N
F
A
V
T
E
D
T
N
V
T
D
S
D
Y
T
Y
-
G
F
I
S
G
A
G
L
S
A
G
L
W
S
N
S
------
E
H
D
--------
G
T
YVAAPV
R
G
------
G
S
Q
N
T
R
V
Y
A
T
T
Q
Q
T
G
D
A
T
S
L
G
L
A
S
A
P
W
Y
Y
H
R
T
V
---
T
D
SKG
K
K
Y
T
V
A
E
T
A
L
P
Q
M
A
V
A
I
A
G
D
E
N
E
D
G
A
V
N
W
Q
D
G
A
I
A
Y
R
D
I
M
N
N
P
Y
K
-------
S
E
E
V
P
E
L
V
A
W
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
T
T
L
D
N
V
K
K
V
--
A
L
N
T
D
G
L
G
Q
S
-
V
L
-
L
K
G
Y
G
N
E
G
H
D
S
G
H
P
D
Y
G
D
I
G
Q
R
L
G
G
A
D
D
M
N
T
M
M
E
E
G
S
K
Y
G
A
R
F
G
V
H
V
N
A
S
E
M
Y
P
E
A
K
A
F
S
E
D
M
V
R
R
N
S
A
G
G
L
S
Y
G
W
N
W
L
-
D
-
Q
G
V
G
I
D
G
I
Y
D
L
A
S
G
S
R
V
-
S
R
F
A
D
L
S
K
E
V
G
D
N
M
D
F
I
Y
L
D
V
W
G
-
N
-
L
-----------
T
S
S
G
S
E
D
S
W
E
T
R
K
M
S
K
M
I
N
D
N
G
W
R
M
T
T
E
W
G
S
G
N
E
Y
D
S
T
F
Q
H
W
A
A
D
L
T
Y
G
G
Y
T
S
K
G
E
N
S
E
V
M
R
F
L
R
N
H
Q
K
D
S
W
V
G
D
Y
P
Q
Y
G
G
A
A
N
A
P
L
L
G
G
Y
N
M
K
D
F
E
G
W
Q
G
R
N
D
Y
A
A
Y
I
K
N
L
Y
T
H
D
V
S
T
K
F
I
Q
H
F
K
V
T
R
W
V
N
N
P
L
L
-
T
A
D
N
-----
G
N
A
AAVSDP
N
T
N
N
-
G
N
E
-----
Q
I
T
L
K
D
S
N
G
N
V
V
V
V
S
R
G
S
N
D
T
S
S
A
A
Y
R
Q
R
T
I
T
F
N
G
V
K
V
A
-------
S
G
V
V
SAGDGSATGD
E
------------
S
-----
Y
L
L
P
W
M
W
D
-
S
F
T
G
K
L
V
K
D
S
E
Q
-
K
L
Y
H
W
N
T
K
G
G
T
T
T
W
T
L
P
D
S
W
K
-
N
-
L
S
S
V
K
V
Y
Q
L
T
D
Q
G
K
T
N
E
Q
T
V
A
V
S
G
G
K
V
T
L
T
A
D
A
E
T
P
Y
V
V
Y
K
G
E
A
K
Q
I
Q
V
N
W
S
E
G
M
H
V
V
D
A
G
F
N
G
G
S
N
T
L
T
D
N
W
T
V
S
G
S
G
K
-
A
E
V
E
G
--
D
N
N
A
-
M
L
R
L
T
G
---
K
V
D
V
S
Q
R
L
T
D
L
K
A
G
Q
K
Y
A
L
Y
V
G
V
D
N
R
S
T
G
D
A
S
V
T
V
T
S
G
-
G
K
V
L
A
T
N
-
S
T
G
K
S
I
A
K
N
Y
I
K
A
Y
G
H
N
T
N
--
S
N
T
E
N
G
S
S
Y
F
Q
N
M
Y
V
F
F
T
A
P
E
N
-
G
D
A
T
V
T
L
S
H
K
S
T
D
G
-
A
H
-
T
Y
F
D
D
V
R
I
V
E
N
Q
Y
S
G
I
T
Y
E
K
D
G
T
L
K
S
L
T
N
G
F
E
N
N
A
Q
G
I
W
P
F
V
V
S
G
S
E
G
V
E
D
N
R
I
H
L
S
E
L
H
A
P
F
T
R
A
G
W
D
V
K
K
M
D
D
V
L
D
G
T
W
S
V
K
V
N
G
L
T
Q
K
G
T
L
V
Y
Q
T
I
P
Q
N
V
K
F
E
A
G
A
K
Y
K
V
S
F
D
Y
Q
S
G
S
D
D
I
Y
A
I
A
V
G
Q
G
E
Y
S
A
G
-------
S
V
K
L
T
N
L
K
K
A
L
---
G
E
T
G
K
A
E
F
E
L
T
G
G
V
N
G
D
S
W
F
G
I
Y
S
T
A
T
A
P
D
L
Q
G
S
T
G
N
A
Q
D
F
G
G
Y
K
D
F
V
L
D
N
L
K
I
E
R
I
---------------
E
S
Q
T
RT
K
A
----
E
A
Q
D
K
V
K
E
I
R
G
K
Y
DS--
K
R
------
A
W
Q
Q
Y
Q
D
T
L
V
K
A
R
V
--
L
I
N
K
N
G
A
T
A
E
D
F
T
K
A
Y
D
I
L
V
A
L
D
E
Y
M
K
T
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
54.14
44%
67
- C1 -
-
2ZXQ
3
?
A:
[23-1206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
E
T
L
K
T
K
K
M
E
V
Q
I
K
K
N
F
P
S
V
L
Q
Y
T
M
T
D
G
K
V
M
Y
G
Q
S
K
D
V
R
T
V
E
I
N
G
T
N
I
E
L
G
D
D
D
V
T
F
K
K
V
S
D
T
E
A
T
Y
T
L
K
V
K
D
E
A
K
K
I
D
A
V
I
T
V
Q
I
T
V
K
A
N
Q
L
H
L
N
V
T
K
I
K
N
N
LS
E
G
I
P
E
G
N
G
V
--
E
E
N
A
I
Q
T
L
S
F
P
N
Q
S
L
V
S
V
R
S
S
Q
E
N
A
Q
F
T
G
A
R
M
S
S
N
T
Q
K
P
G
D
T
N
F
A
V
T
E
D
T
N
V
T
D
S
D
Y
T
Y
-
G
F
I
S
G
A
G
L
S
A
G
L
W
S
N
S
------
E
H
D
GTYVAAPV
R
G
------
G
S
------
Q
N
--
T
R
V
Y
A
T
T
Q
Q
T
G
D
A
T
S
L
G
L
A
S
A
P
W
Y
Y
H
R
T
V
T
D
S
K
G
---
K
K
Y
T
V
A
E
T
A
L
P
Q
M
A
V
A
I
A
G
D
E
N
E
D
G
A
V
N
W
Q
D
G
A
I
A
Y
R
D
I
M
N
N
P
Y
K
-------
S
E
E
V
P
E
L
V
A
W
R
I
A
M
----------
N
----
F
G
-
S
Q
--
A
Q
N
P
F
L
T
T
L
D
N
V
K
K
V
--
A
L
N
T
D
G
L
G
Q
S
-
V
L
-
L
K
G
Y
G
N
E
G
H
D
S
G
H
P
D
Y
G
D
I
G
Q
R
L
G
G
A
D
D
M
N
T
M
M
E
E
G
S
K
Y
G
A
R
F
G
V
H
V
N
A
S
E
M
Y
P
E
A
K
A
F
S
E
D
M
V
R
R
N
S
A
G
G
L
S
Y
G
W
N
W
L
-
D
-
Q
G
V
G
I
D
G
I
Y
D
L
A
S
G
S
R
V
-
S
R
F
A
D
L
S
K
E
V
G
D
N
M
D
F
I
Y
L
D
V
W
G
-
N
L
T
-----------
S
-
S
G
S
E
D
S
W
E
T
R
K
M
S
K
M
I
N
D
N
G
W
R
M
T
T
E
W
G
S
G
N
E
Y
D
S
T
F
Q
H
W
A
A
D
L
T
Y
G
G
Y
T
S
K
G
E
N
S
E
V
M
R
F
L
R
N
H
Q
K
D
S
W
V
G
D
Y
P
Q
Y
G
G
A
A
N
A
P
L
L
G
G
Y
N
M
K
D
F
E
G
W
Q
G
R
N
D
Y
A
A
Y
I
K
N
L
Y
T
H
D
V
S
T
K
F
I
Q
H
F
K
V
T
R
W
V
N
-
N
P
L
L
T
A
D
N
-----
G
N
A
------
A
A
V
S
D
P
N
T
NNG
N
E
Q
I
T
L
K
D
S
N
G
N
V
V
V
V
S
R
G
S
N
D
T
S
S
A
A
Y
R
Q
R
T
I
T
F
N
G
V
K
V
A
S
G
V
V
SAG
D
G
------------
S
------------
A
TGDES
Y
L
L
P
W
M
W
D
-
S
F
-
T
G
K
L
V
K
D
S
E
Q
K
L
Y
H
W
N
T
K
G
G
T
T
T
W
T
L
P
D
S
W
K
-
N
L
S
-
S
V
K
V
Y
Q
L
T
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Q
G
K
T
N
E
Q
T
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A
V
S
G
G
K
V
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L
T
A
D
A
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P
Y
V
V
Y
K
G
E
A
K
Q
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V
N
W
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G
M
H
V
V
D
A
G
F
N
G
G
S
N
T
L
T
D
N
W
T
V
S
G
-
S
G
K
A
E
V
---
E
G
D
N
N
A
M
L
R
L
T
G
---
K
V
D
V
S
Q
R
L
T
D
L
K
A
G
Q
K
Y
A
L
Y
V
G
V
D
N
R
S
T
G
D
A
S
V
T
V
T
S
G
-
G
K
V
-
L
A
T
N
S
T
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K
S
I
A
K
N
Y
I
K
A
Y
G
H
N
T
N
S
N
--
T
E
N
G
S
S
Y
F
Q
N
M
Y
V
F
F
T
A
P
E
N
-
G
D
A
T
V
T
L
S
H
K
S
T
-
D
-
G
A
H
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Y
F
D
D
V
R
I
V
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N
Q
Y
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G
I
T
Y
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K
D
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L
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L
T
N
G
F
E
N
N
A
Q
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I
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V
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S
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G
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E
D
N
R
I
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L
H
A
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R
A
G
W
D
V
K
K
M
D
D
V
L
D
G
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K
V
N
G
L
T
Q
K
G
T
L
V
Y
Q
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I
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Q
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K
F
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A
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A
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K
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Y
Q
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D
D
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A
I
A
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G
Q
G
E
Y
S
A
G
-------
S
V
K
L
T
N
L
K
K
A
L
G
E
T
G
K
A
E
---
F
E
L
T
G
G
V
N
G
D
S
W
F
G
I
Y
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A
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A
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L
Q
G
S
T
G
N
A
Q
D
F
G
G
Y
K
D
F
V
L
D
N
L
K
I
E
R
I
E
S
QTRT
K
A
E
A
Q
D
K
V
K
E
I
R
G
--
K
Y
DSKR----
A
W
Q
Q
Y
Q
D
T
L
V
K
A
R
V
L
I
N
K
N
G
A
T
A
E
D
F
T
K
A
Y
D
I
L
V
A
--
L
D
--
E
Y
M
K
T
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
34.25
39%
-272
- C1 -
-
4ZXW
2
?
B:
[420-459]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
A
G
S
L
G
Y
N
T
-
N
R
F
K
D
E
T
M
A
A
F
L
A
D
Y
L
D
V
L
E
N
A
V
A
R
P
D
A
P
--------------------------------------------------------------------
29
PsiBlast_CBE
32.88
39%
-250
- C1 -
-
4ZXW
1
?
A:
[420-459]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
A
G
S
L
G
Y
N
T
-
N
R
F
K
D
E
T
M
A
A
F
L
A
D
Y
L
D
V
L
E
N
A
V
A
R
P
D
A
P
--------------------------------------------------------------------
43
HHSearch
32.44
14%
7
- C1 -
-
5WZQ
1
?
B:
[78-508]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
A
F
E
T
Y
I
W
I
E
R
S
S
G
D
V
L
C
E
W
V
P
L
R
E
------------------
I
D
R
V
L
W
P
A
P
L
S
F
D
R
A
D
-
A
H
D
V
T
L
--
I
T
-----
H
E
Q
G
-
V
M
I
P
N
S
W
P
T
E
V
G
T
D
A
V
S
F
G
G
R
F
E
T
A
G
G
Y
M
P
W
F
A
Q
L
------
R
S
D
--------
G
H
------
A
Y
I
A
I
CET
P
W
N
A
G
Y
D
I
D
H
P
A
G
G
-
P
Y
T
H
V
G
----
M
W
F
E
P
S
L
-------------
G
R
M
D
Y
R
R
V
V
R
Y
R
L
L
D
------
H
A
D
H
T
A
I
C
K
T
Y
R
A
Y
V
N
E
R
G
R
LRT
L
A
E
K
A
A
R
N
P
S
V
R
D
L
L
G
R
S
W
V
A
V
G
I
K
T
N
V
Q
PDSS
F
Y
D
P
A
QP
G
K
N
D
S
L
V
T
F
A
Q
R
E
R
Q
M
R
T
L
H
E
M
G
A
G
R
L
Y
L
A
-
L
A
G
W
A
Q
P
G
Y
D
N
G
H
P
D
Y
L
P
A
C
R
E
A
G
G
W
K
G
M
K
S
L
I
D
A
C
H
E
Q
G
D
L
F
G
T
A
D
Q
Y
R
D
Y
Y
F
A
A
R
T
F
D
P
R
N
A
I
R
L
A
D
G
T
M
P
E
H
A
M
W
A
G
G
-
R
Q
T
Y
L
C
A
E
L
--
A
P
D
-
Y
V
R
R
N
F
S
E
I
A
T
-
H
G
I
V
L
D
C
A
Y
L
D
V
F
T
-
C
-
N
E
G
D
E
C
SHPE
H
R
M
-
T
R
R
E
C
Y
E
R
R
A
E
C
F
E
Y
L
L
A
H
G
I
L
T
S
S
E
E
V
S
D
--
W
A
V
P
S
L
V
F
C
H
Y
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
31.24
27%
35
- C2 -
-
2V72
1
?
A:
[25-143]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
D
P
---
A
S
S
A
I
D
G
N
I
N
T
M
W
H
T
K
W
N
G
S
D-
A
-
L
P
Q
S
L
S
V
N
L
G
K
A
R
K
V
S
S
I
A
I
T
P
R
T
S
G
N
N
G
F
I
T
K
Y
E
I
H
A
I
N
N
G
V
E
T
L
V
A
-
E
G
-------
T
W
E
E
N
N
L
V
K
T
V
T
F
D
S
P
I
D
A
E
E
I
K
I
T
A
I
Q
G
V
G
----
G
F
A
S
I
A
E
L
N
V
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
30.57
20%
17
- C2 -
-
2KD7
-
?
A:
[27-150]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
L
---
A
K
C
L
I
D
G
D
T
E
T
F
W
H
A
K
W
Q
G
G
SD
P
-
L
P
Y
D
I
V
I
D
M
K
Q
N
I
Q
I
A
Q
V
E
L
L
P
R
G
R
G
S
N
N
P
I
K
V
V
E
F
A
A
S
E
D
N
V
N
W
T
P
I
G
R
F
-------
G
F
T
N
Q
D
A
A
L
E
Y
Y
V
K
-
S
I
K
A
R
Y
I
R
L
T
I
P
D
D
G
G
N
--
S
T
V
A
A
I
R
E
L
D
V
K
G
T
I
I
------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
30.23
16%
13
- C1 -
-
5WZR
1
?
A:
[78-484]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
A
F
E
T
Y
I
W
I
E
R
S
S
G
D
V
L
C
E
W
V
P
L
R
E
C
------------
G
A
E
P
R
I
D
R
V
L
W
P
A
P
L
S
F
D
R
A
-
D
A
H
D
V
T
L
--
I
T
-----
H
E
Q
G
-
V
M
I
P
N
S
W
P
T
E
V
G
T
D
A
V
S
F
G
G
R
F
E
T
A
G
G
Y
M
P
W
F
A
Q
L
------
R
S
D
--------
G
H
------
A
Y
I
A
I
C
ET
P
W
N
A
G
Y
D
I
D
H
P
A
G
G
-
P
Y
T
H
V
G
----
M
W
F
E
P
S
L
-----
G
--------
R
M
D
Y
R
R
V
V
R
Y
R
L
L
D
------
H
A
D
H
T
A
I
C
K
T
Y
R
A
Y
V
N
E
R
G
R
LRT
L
A
E
K
A
A
R
N
P
S
V
R
D
L
L
G
R
S
W
V
H
V
G
I
K
T
N
V
Q
PDSS
F
Y
D
P
A
Q
P
G
K
N
D
S
L
V
T
F
A
Q
R
E
R
Q
M
R
T
L
H
E
M
G
A
G
R
L
-
Y
L
H
L
D
G
W
A
Q
P
G
Y
D
N
G
H
P
D
Y
L
P
A
C
R
E
A
G
G
W
K
G
M
K
S
L
I
D
A
C
H
E
Q
G
D
L
F
G
T
H
D
Q
Y
R
D
Y
Y
F
A
A
R
T
F
D
P
R
N
A
I
R
L
A
D
G
T
M
P
E
H
A
M
W
A
-
G
G
R
Q
T
Y
L
C
A
E
--
L
A
P
D
-
Y
V
R
R
N
F
S
E
I
A
T
-
H
G
I
V
L
D
C
A
Y
L
D
V
F
T
-
C
-
N
E
G
D
E
C
SHPE
H
R
M
-
T
R
R
E
C
Y
E
R
R
A
E
C
F
E
Y
L
L
A
H
G
I
L
T
S
S
E
E
V
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
30.11
31%
80
- C2 -
-
2V72
1
?
A:
[16-139]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
A
S
A
T
S
E
E
G
QDP
A
S
S
A
I
D
G
N
I
N
T
M
W
H
T
K
W
N
G
S
--
D
A
L
P
Q
S
L
S
V
N
L
G
K
A
R
K
V
S
S
I
A
I
T
P
R
T
S
G
N
N
G
F
I
T
K
Y
E
I
H
A
I
N
-
N
G
V
E
T
L
V
A
E
G
-------
T
W
E
E
N
N
L
V
K
T
V
T
F
D
S
P
I
D
A
E
E
I
K
I
T
A
I
Q
--
G
V
G
G
--
F
A
S
I
A
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
29.95
20%
13
- C2 -
-
4LPL
-
?
A:
[60-182]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
E
---
P
S
K
A
V
D
G
D
D
S
S
Q
F
H
S
Q
D
S
----
A
-
I
D
K
P
F
I
I
D
M
Q
K
A
Y
T
I
E
K
L
E
L
L
F
R
K
N
-
G
N
G
S
V
K
R
A
E
I
Y
S
S
L
D
G
V
T
Y
E
K
V
F
S
N
AEGSD
I
A
P
W
A
T
D
G
E
V
K
T
I
N
F
N
K
P
I
K
V
R
Y
F
K
I
V
T
K
E
S
I
G
----
N
F
L
A
M
R
E
F
R
P
Y
K
---------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
29.59
27%
42
- C2 -
-
4A41
1
?
A:
[45-161]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---
A
K
F
A
I
D
G
K
E
N
T
I
W
H
T
K
Y
N
P
V
E-
E
-
L
P
Q
S
I
T
L
E
L
G
G
S
Y
E
I
N
K
F
T
Y
L
P
R
S
G
A
K
N
G
N
I
T
K
Y
E
L
H
V
S
E
D
G
N
N
F
R
K
I
S
E
G
-------
N
W
D
D
S
G
S
L
K
T
L
K
F
N
-
S
T
K
A
T
H
V
K
L
V
A
L
E
G
V
G
----
G
F
A
S
A
A
E
L
N
V
F
A
---------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
29.57
27%
44
- C2 -
-
4A44
1
?
A:
[45-161]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---
A
K
F
A
I
D
G
K
E
N
T
I
W
H
T
K
Y
N
P
V
E-
E
-
L
P
Q
S
I
T
L
E
L
G
G
S
Y
E
I
N
K
F
T
Y
L
P
R
S
G
A
K
N
G
N
I
T
K
Y
E
L
H
V
S
E
D
G
N
N
F
R
K
I
S
E
G
-------
N
W
D
D
S
G
S
L
K
T
L
K
F
N
-
S
T
K
A
T
H
V
K
L
V
A
L
E
G
V
G
----
G
F
A
S
A
A
E
L
N
V
F
A
---------------------------------------------------------------------------------------------------------------------------------------------