@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0377: (2017-12-21 )
MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAKKLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDGAGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI
Atome Classification :
(35 SA)
.........10........20........30........40......-..50..-......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.----......-.180....-...190.......200-......--.210.......220.......230.......240.......250.......260...-....270-.......280.......290......-.300-........310.......320..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
VVTN
H
D
L
A
Q
I
MDT
N
D
E
W
I
S
S
RTG
I
R
Q
R
HISR-TES
T
S
D
-
L
A
T
E
V
A
K
K
L
M
A
KAGITGEEL
D
F
I
I
L
A
T
ITPDSMMPST
A
A
R
V
Q
A
NIGAN
K
A
F
A
F
D
L
T
A
ACS
G
F
V
F
A
L
S
T
A
E
K
F
I
ASGRFQK
G
L
V
I
G
S
E
T
L
S
K
AVDWSDR
S
T
A
V
L
F
GDGAG
G
V
L
L
EAS
E
Q
-
E
----
H
F
L
A
E
S-LNSDGS
R
S
-
E
C
L
T
YGHSGLHSPFSD-
Q
E
S
A
D
S
--
F
L
KMDG
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
IDESPIEVTD
L
D
Y
L
L
L
HQAN
D
R
I
L
D
K
M
A
R
K
IGV-
D
R
AKL
P
A
-
N
M
M
EYGNTSAA
S
I
P
I
L
L
S
E
C
V
EQGLI-PLD--GS
Q
T
V
L
L
SGFGGG
L
T
W
G
T
L
I
L
TI
1
PsiBlast_PDB
87.23
99%
-105
- C2 -
-
5BQS
1
FABH_STRZP
A:
[1-323]
-
A
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
V
V
T
N
H
D
L
A
Q
I
M
D
T
N
D
E
W
I
S
S
R
T
G
I
R
Q
R
H
I
S
R
-
T
E
S
T
S
D
-
L
A
T
E
V
A
K
K
L
M
A
K
A
G
I
T
G
K
E
L
D
F
I
I
L
A
T
I
T
P
D
S
M
M
P
S
T
A
A
R
V
Q
A
N
I
G
A
N
K
A
F
A
F
D
L
T
A
A
C
S
G
F
V
F
A
L
S
T
A
E
K
F
I
A
S
G
R
F
Q
K
G
L
V
I
G
S
E
T
L
S
K
A
V
D
W
S
D
R
S
T
A
V
L
F
G
D
G
A
G
G
V
L
L
E
A
S
E
Q
-
E
----
H
F
L
A
E
S
-
L
N
S
D
G
S
R
S
-
E
C
L
T
Y
G
H
S
G
L
H
S
P
F
S
D
-
Q
E
S
A
D
S
--
F
L
K
M
D
G
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
I
D
E
S
P
I
E
V
T
D
L
D
Y
L
L
L
H
Q
A
N
D
R
I
L
D
K
M
A
R
K
I
G
V
-
D
R
A
K
L
P
A
-
N
M
M
E
Y
G
N
T
S
A
A
S
I
P
I
L
L
S
E
C
V
E
Q
G
L
I
-
P
L
D
--
G
S
Q
T
V
L
L
S
G
F
G
G
G
L
T
W
G
T
L
I
L
T
I
21
PsiBlast_CBE
87.20
99%
-105
- C2 -
-
5BQS
1
FABH_STRZP
B:
[1-323]
-
A
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
V
V
T
N
H
D
L
A
Q
I
M
D
T
N
D
E
W
I
S
S
R
T
G
I
R
Q
R
H
I
S
R
-
T
E
S
T
S
D
-
L
A
T
E
V
A
K
K
L
M
A
K
A
G
I
T
G
K
E
L
D
F
I
I
L
A
T
I
T
P
D
S
M
M
P
S
T
A
A
R
V
Q
A
N
I
G
A
N
K
A
F
A
F
D
L
T
A
A
C
S
G
F
V
F
A
L
S
T
A
E
K
F
I
A
S
G
R
F
Q
K
G
L
V
I
G
S
E
T
L
S
K
A
V
D
W
S
D
R
S
T
A
V
L
F
G
D
G
A
G
G
V
L
L
E
A
S
E
Q
-
E
----
H
F
L
A
E
S
-
L
N
S
D
G
S
R
S
-
E
C
L
T
Y
G
H
S
G
L
H
S
P
F
S
D
-
Q
E
S
A
D
S
--
F
L
K
M
D
G
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
I
D
E
S
P
I
E
V
T
D
L
D
Y
L
L
L
H
Q
A
N
D
R
I
L
D
K
M
A
R
K
I
G
V
-
D
R
A
K
L
P
A
-
N
M
M
E
Y
G
N
T
S
A
A
S
I
P
I
L
L
S
E
C
V
E
Q
G
L
I
-
P
L
D
--
G
S
Q
T
V
L
L
S
G
F
G
G
G
L
T
W
G
T
L
I
L
T
I
81
HHSearch
82.02
98%
-46
- C2 -
-
5BQS
1
FABH_STRZP
B:
[1-323]
-
A
F
A
K
I
S
Q
V
A
H
Y
V
P
E
Q
V
V
T
N
H
D
L
A
Q
I
M
D
T
N
D
E
W
I
S
S
R
T
G
I
R
Q
R
H
I
S
R
-
T
E
S
T
S
D
-
L
A
T
E
V
A
K
K
L
M
A
K
A
G
I
T
G
K
E
L
D
F
I
I
L
A
T
I
T
P
D
S
M
M
P
S
T
A
A
R
V
Q
A
N
I
G
A
N
K
A
F
A
F
D
L
T
A
A
C
S
G
F
V
F
A
L
S
T
A
E
K
F
I
A
S
G
R
F
Q
K
G
L
V
I
G
S
E
T
L
S
K
A
V
D
W
S
D
R
S
T
A
V
L
F
G
D
G
A
G
G
V
L
L
E
A
S
E
Q
-
E
----
H
F
L
A
E
S
-
L
N
S
D
G
S
R
S
E
C
L
-
T
Y
G
H
S
G
L
H
S
P
F
S
D
-
Q
E
S
A
D
S
--
F
L
K
M
D
G
R
T
V
F
D
F
A
I
R
D
V
A
K
S
I
K
Q
T
I
D
E
S
P
I
E
V
T
D
L
D
Y
L
L
L
H
Q
A
N
D
R
I
L
D
K
M
A
R
K
I
G
V
-
D
R
A
K
L
P
A
-
N
M
M
E
Y
G
N
T
S
A
A
S
I
P
I
L
L
S
E
C
V
E
Q
G
---
L
I
P
LD
G
S
Q
T
V
L
L
S
G
F
G
G
G
L
T
W
G
T
L
I
L
T
I
2
PsiBlast_PDB
71.98
57%
-71
- C2 -
-
3IL5
1
FABH_ENTFA
A:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
T
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
----
H
F
L
N
E
K
-
L
Q
A
D
G
Q
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
-----
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
-
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
23
PsiBlast_CBE
71.87
57%
-66
- C2 -
-
3IL5
1
FABH_ENTFA
C:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
T
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
----
H
F
L
N
E
K
-
L
Q
A
D
G
Q
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
-----
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
-
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
22
PsiBlast_CBE
70.66
57%
-71
- C2 -
-
3IL5
1
FABH_ENTFA
D:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
T
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
----
H
F
L
N
E
K
-
L
Q
A
D
G
Q
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
-----
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
-
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
24
PsiBlast_CBE
70.14
57%
-64
- C2 -
-
3IL5
1
FABH_ENTFA
B:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
-
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
T
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
----
H
F
L
N
E
K
-
L
Q
A
D
G
Q
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
-----
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
-
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
3
PsiBlast_PDB
68.46
57%
-70
- C2 -
-
3IL4
1
FABH_ENTFA
A:
[3-320]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
T
S
D
-
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
----
H
F
L
N
E
K
-
L
Q
A
D
G
Q
R
W
-
T
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
--
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
T
D
E
T
V
-----
D
Y
L
L
L
H
Q
A
S
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
-
I
L
G
--
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
90
HHSearch
63.72
40%
-59
- C2 -
-
4X0O
1
FABH2_VIBCH
E:
[3-324]
Q
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
--
V
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
K
V
----
G
L
Q
D
A
Q
-
I
G
C
D
A
Q
G
R
D
I
L
-
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
---
K
I
K
--
P
H
D
D
L
L
V
A
A
F
G
A
G
L
T
W
G
A
G
H
I
R
W
37
PsiBlast_CBE
63.51
41%
-76
- C2 -
-
4X0O
1
FABH2_VIBCH
A:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
36
PsiBlast_CBE
63.48
41%
-75
- C2 -
-
4X0O
1
FABH2_VIBCH
B:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
31
PsiBlast_CBE
63.33
41%
-75
- C2 -
-
4X0O
1
FABH2_VIBCH
H:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
32
PsiBlast_CBE
63.31
41%
-75
- C2 -
-
4X0O
1
FABH2_VIBCH
G:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
33
PsiBlast_CBE
63.17
41%
-75
- C2 -
-
4X0O
1
FABH2_VIBCH
F:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
38
PsiBlast_CBE
63.12
41%
-76
- C2 -
-
5V0P
2
FABH2_VIBCH
B:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
85
HHSearch
63.04
44%
-66
* C2 *
-
2EBD
-
FABH_AQUAE
A:
[1-309]
-
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
-
E
E
T
I
T
Y
-
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
----
D
I
L
A
T
R
-
M
Y
A
E
G
S
L
E
-
E
L
L
H
A
D
--------------
N
C
G
--
Y
I
R
M
K
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
-
P
K
E
K
V
F
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
K
E
G
---
K
V
K
--
R
G
D
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
34
PsiBlast_CBE
62.96
41%
-74
- C2 -
-
4X0O
1
FABH2_VIBCH
E:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
-
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
27
PsiBlast_CBE
62.94
39%
-39
- C2 -
-
4Z8D
1
FABH_ECOLI
B:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
39
PsiBlast_CBE
62.87
41%
-75
- C2 -
-
5V0P
2
FABH2_VIBCH
A:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
6
PsiBlast_PDB
62.75
41%
-80
- C2 -
-
4X0O
1
FABH2_VIBCH
D:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
C
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
70
HHSearch
62.63
39%
-33
- C2 -
-
1HNJ
1
FABH_ECOLI
A:
[1-317]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
E
L
L
-
T
L
P
N
A
D
R
V
N
P
------
E
N
S
I
--
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
---
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
14
PsiBlast_PDB
62.17
39%
-34
- C2 -
-
5BNM
1
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
26
PsiBlast_CBE
61.67
39%
-35
- C2 -
-
5BNM
1
FABH_ECOLI
B:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
71
HHSearch
61.38
39%
-33
- C2 -
-
2GYO
2
FABH_ECOLI
A:
[1-317]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
E
L
L
-
T
L
P
N
A
D
R
V
N
P
------
E
N
S
I
--
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
---
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
40
PsiBlast_CBE
61.35
41%
-80
- C2 -
-
5KP2
2
FABH2_VIBCH
B:
[4-318]
-
C
Y
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
H
-
V
-
N
T
S
D
-
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
A
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
-
K
----
V
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
-
D
I
L
A
V
P
K
F
G
T
A
M
D
R
F
D
-
A
D
N
G
Y
W
--
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
K
A
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
E
Q
G
K
I
K
P
H
D
-----
D
L
L
V
A
A
F
G
A
G
L
T
W
G
------
13
PsiBlast_PDB
61.24
39%
-35
- C2 -
-
4Z8D
1
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
25
PsiBlast_CBE
61.22
39%
-36
- C2 -
-
5BNS
1
FABH_ECOLI
B:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
9
PsiBlast_PDB
61.20
39%
-35
- C2 -
-
1HNJ
1
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
8
PsiBlast_PDB
60.76
39%
-33
- C2 -
-
1HND
1
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
15
PsiBlast_PDB
60.72
39%
-37
- C2 -
-
5BNS
1
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
11
PsiBlast_PDB
60.59
39%
-34
- C2 -
-
2EFT
2
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
12
PsiBlast_PDB
60.33
39%
-39
- C2 -
-
2GYO
2
FABH_ECOLI
A:
[2-315]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
-
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
----
G
I
I
S
T
H
-
L
H
A
D
G
S
Y
G
-
E
L
L
T
L
-------
P
N
A
D
-
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
---
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
--
88
HHSearch
56.76
31%
-39
- C2 -
-
1MZJ
2
FABH_STRLI
A:
[9-331]
R
R
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
D
E
T
I
Q
V
-
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
V
-
P
GI
G
P
V
V
R
G
I
D
-
G
T
G
L
G
S
L
-----
H
M
S
S
S
W
D
Q
Y
V
E
D
--
P
S
V
G
R
P
--
A
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
-
P
E
H
V
V
V
S
R
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
R
S
G
---
A
V
P
--
G
G
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
48
PsiBlast_CBE
55.29
31%
-35
- C2 -
-
1MZJ
2
FABH_STRLI
A:
[11-324]
--
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
T
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
V
-
P
----
G
I
G
P
V
V
-
R
G
I
D
G
T
G
L
-
G
S
L
-
H
M
S
S
S
W
D
Q
Y
V
E
D
-
P
S
V
G
R
P
--
A
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
S
R
-
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
R
S
G
A
V
-
P
----
G
G
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
-------
47
PsiBlast_CBE
55.07
31%
-37
- C2 -
-
1MZJ
2
FABH_STRLI
B:
[11-324]
--
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
T
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
V
-
P
----
G
I
G
P
V
V
-
R
G
I
D
G
T
G
L
-
G
S
L
-
H
M
S
S
S
W
D
Q
Y
V
E
D
-
P
S
V
G
R
P
--
A
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
S
R
-
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
R
S
G
A
V
-
P
----
G
G
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
-------