@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0379: (2017-12-21 )
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAVSIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVEGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
Atome Classification :
(20 SA)
-.........10........20........30........40....-..-.-.50........60........70.-----------------..-----.----.------------------------------...80------------.........90........-100.......110.......120.......130.......140....---------.---------.--.150.......160.......170.......180.......190.......200.......210.......220.......230.......-240.......250.......260-.......270........280.......290.......300.......310.......320..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MK
T
R
I
T
E
L
L
KIDYPIFQG
G
M
A
W
VADGD
L
A
G
A
V
SKAG
G
L
G
I
IGGGN-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
LTDKPF
G
V
N
I
M
L
-----------------L
S
-----
P
----
F
------------------------------
V
E
D
I
-------------
V
D
L
V
I
EEG
V
K
V
V
T
TGAG
N
P
-
S
K
Y
M
E
R
F
H
EA
G
I
I
V
I
PVV
P
S
V
A
L
A
K
R
M
E
K
IG
A
D
A
V
I
A
E
G
M
E
AGGHIG---------
K
---------
L
--
T
T
M
T
L
V
R
Q
V
A
T
AVS
I
P
V
I
A
AGGIADGEGAA
A
G
F
M
L
G
A
E
A
V
QVG
T
R
F
V
V
A
KESNAHP
N
Y
K
E
K
I
L
K
ARDIDT
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
TRD-
F
E
L
A
E
K
DAFKQEDP
D
L
E
I
F
E
Q
MG-
A
G
A
L
A
K
A
V
V-HGDVEGGS
V
M
A
G
Q
I
A
G
LVS
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
RWTGVVRND
96
HHSearch
93.38
99%
-105
- C6 -
-
2Z6I
1
?
B:
[1-321]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----------------
L
S
-----
P
----
F
------------------------------
V
E
D
I
-------------
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
---------
L
--
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
-
F
E
L
A
E
K
D
A
F
K
Q
E
D
P
D
L
E
I
F
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
V
---
95
HHSearch
93.28
99%
-105
- C6 -
-
2Z6I
2
?
A:
[1-320]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----------------
L
S
-----
P
----
F
------------------------------
V
E
D
I
-------------
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
---------
L
--
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
-
F
E
L
A
E
K
D
A
F
K
Q
---
D
L
E
I
F
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
----
2
PsiBlast_PDB
91.24
96%
-103
- C6 -
-
2Z6I
2
?
A:
[2-320]
--
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----------------
L
S
-----
P
----
F
------------------------------
V
E
D
I
-------------
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
---------
L
--
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
-
F
E
L
A
E
K
D
A
F
K
Q
---
D
L
E
I
F
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
----
1
PsiBlast_PDB
90.54
99%
-105
- C6 -
-
2Z6J
3
?
A:
[1-320]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----------------
L
S
-----
P
----
F
------------------------------
V
E
D
I
-------------
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
---------
L
--
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
---
H
A
V
R
A
I
K
N
Q
L
T
R
D
-
F
E
L
A
E
K
D
A
F
----------
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
----
21
PsiBlast_CBE
89.68
99%
-103
- C6 -
-
2Z6J
2
?
B:
[1-321]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----------------
L
S
-----
P
----
F
------------------------------
V
E
D
I
-------------
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
---------
L
--
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
----
A
V
R
A
I
K
N
Q
L
T
R
D
-
F
E
L
A
E
K
D
A
F
----------
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
V
---
5
PsiBlast_PDB
76.67
48%
-108
- C6 -
-
3BO9
7
?
A:
[15-324]
-
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
-----------------
V
S
-----
P
----
W
------------------------------
A
D
D
L
-------------
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
---------
V
--
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
-
I
Q
E
M
E
F
E
N
P
M
Q
A
E
E
M
L
--------
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
----
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
---
3
PsiBlast_PDB
76.53
49%
-104
- C6 -
-
5GVH
1
?
A:
[3-312]
-
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
-----------------
V
S
-----
P
----
W
------------------------------
A
D
D
L
-------------
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
---------
V
--
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
-
I
Q
E
M
E
F
E
N
P
M
Q
A
-------
E
E
M
L
-
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
----
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
---
101
HHSearch
76.28
50%
-104
- C6 -
-
5GVH
1
?
A:
[3-312]
-
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
-----------------
V
S
-----
P
----
W
------------------------------
A
D
D
L
-------------
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
---------
V
--
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
-
I
Q
E
M
E
F
E
-----
N
P
M
Q
--
A
E
E
M
L
-
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
-------
97
HHSearch
74.00
50%
-108
- C6 -
-
5GVJ
-
?
B:
[3-312]
-
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
-----------------
V
S
-----
P
----
W
------------------------------
A
D
D
L
-------------
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
---------
V
--
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
---
H
P
A
R
V
L
R
T
P
F
A
R
K
-
I
Q
-----------------
E
E
M
L
-
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
A
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
-------
4
PsiBlast_PDB
73.37
49%
-104
- C6 -
-
5GVJ
-
?
A:
[3-312]
-
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
-----------------
V
S
-----
P
----
W
------------------------------
A
D
D
L
-------------
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
---------
V
--
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
----
G
H
P
A
R
V
L
R
T
P
F
A
R
K
-
I
Q
--------------------
L
-
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
A
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
----
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
---
98
HHSearch
65.71
40%
-49
- C6 -
-
4IQL
4
?
A:
[21-331]
--
M
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
H
-
P
-
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
-----------------
L
Y
-----
P
----
E
------------------------------
M
D
K
I
-------------
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
---------
R
---------
E
ET
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
-
A
V
S
P
T
R
L
L
K
N
K
F
Y
Q
D
-
V
F
A
A
E
Q
R
---
G
A
S
V
E
E
--
L
R
E
L
L
G
R
G
R
A
K
Q
G
I
F
-
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
P
T
---------
6
PsiBlast_PDB
64.30
41%
-43
- C6 -
-
4IQL
4
?
A:
[22-326]
---
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
H
-
P
-
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
-----------------
L
Y
-----
P
----
E
------------------------------
M
D
K
I
-------------
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
---------
R
EE-------
T
--
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
V
S
-
P
T
R
L
L
K
N
K
F
Y
Q
D
-
V
F
A
A
E
Q
R
G
A
S
V
E
----
E
L
R
E
L
L
G
-
R
G
R
A
K
Q
G
I
F
-
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
--------------
23
PsiBlast_CBE
64.17
41%
-42
- C6 -
-
4IQL
3
?
B:
[22-326]
---
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
H
-
P
-
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
-----------------
L
Y
-----
P
----
E
------------------------------
M
D
K
I
-------------
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
---------
R
EE-------
T
--
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
V
S
-
P
T
R
L
L
K
N
K
F
Y
Q
D
-
V
F
A
A
E
Q
R
G
A
S
V
E
----
E
L
R
E
L
L
G
-
R
G
R
A
K
Q
G
I
F
-
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
--------------
8
PsiBlast_PDB
59.15
31%
-0
- C6 -
-
2GJN
2
2NPD_PSEAE
A:
[4-320]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
-----------------
L
P
TQKPV
P
----
Y
------------------------------
A
E
-
Y
-------------
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD-------
I
--
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
G
A
G
Y
A
D
I
A
A
L
V
S
G
Q
R
G
-----
R
Q
V
Y
Q
-
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
-----------
100
HHSearch
57.99
31%
3
- C6 -
-
2GJN
2
2NPD_PSEAE
A:
[4-326]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
S
-
P
-
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
-----------------
L
P
-----
T
QKPV
P
------------------------------
Y
A
E
Y
-------------
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD-------
I
--
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
-
V
L
A
I
E
A
R
-
G
G
A
G
Y
A
D
I
A
--
A
L
V
S
-
G
Q
R
G
R
Q
V
Y
Q
-
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-----
7
PsiBlast_PDB
57.88
31%
-0
- C6 -
-
2GJL
1
2NPD_PSEAE
A:
[4-320]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
-----------------
L
P
TQKPV
P
----
Y
------------------------------
A
E
-
Y
-------------
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD-------
I
--
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
G
A
G
Y
A
D
I
A
A
L
V
S
G
Q
R
G
-----
R
Q
V
Y
Q
-
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
-----------
99
HHSearch
57.35
31%
5
- C6 -
-
2GJL
1
2NPD_PSEAE
A:
[4-326]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
S
-
P
-
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
-----------------
L
P
-----
T
QKPV
P
------------------------------
Y
A
E
Y
-------------
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD-------
I
--
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
-
V
L
A
I
E
A
R
-
G
G
A
G
Y
A
D
I
A
--
A
L
V
S
-
G
Q
R
G
R
Q
V
Y
Q
-
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-----
105
HHSearch
56.85
31%
-40
- C6 -
-
5LSM
2
?
A:
[3-348]
---
C
R
L
T
R
L
F
G
I
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
-
L
S
-
L
-
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
-----------------
H
R
-----
E
----
P
VAQ
A
A
K
Q
A
A
W
L
E
Q
L
A
P
Y
F
A
E
F
NLDPNRTPY
S
K
A
Q
-------------
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
---------
H
FLSEDLTEQ
L
--
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
A
A
Q
H
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
M
A
E
-
M
G
P
M
N
E
A
-
V
-
P
D
F
P
----
L
A
S
S
A
-
V
A
G
L
R
T
A
A
E
R
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
S
G
C
R
A
I
P
A
A
-
D
L
T
R
S
F
V
L
S
L
P
-----------------
86
Fugue
56.15
31%
17
- C6 -
-
2GJL
1
2NPD_PSEAE
A:
[3-326]
V
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
S
P
-
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
-----------------
L
P
TQKP-
V
----
P
------------------------------
Y
A
E
Y
-------------
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD-------
I
--
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
-
V
L
A
I
E
A
---
R
G
G
A
G
Y
A
D
I
A
A
L
V
S
-
G
Q
R
G
R
Q
V
Y
Q
-
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-----
13
PsiBlast_PDB
55.23
29%
-49
- C6 -
-
5LSM
2
?
A:
[3-328]
---
C
R
L
T
R
L
F
G
I
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
-
L
S
-
L
-
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
HREPVAQ
A
A
K
Q
A
A
W
L
E
Q
L
A
-----
P
----
Y
------------------------------
F
A
E
F
NLDPNRTPYS
K
A
Q
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
HFLSEDLTE
Q
---------
L
--
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
A
A
Q
H
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
------
M
A
E
M
G
P
M
N
E
A
V
P
D
F
P
L
A
S
S
A
V
-
A
G
L
R
T
A
A
E
R
-
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
--------------------------------------