@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0380: (2017-12-21 )
MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGALDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYNTPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTSLLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASLVALLEK
Atome Classification :
(29 SA)
....--.....10........20........30........40..-..-..-.-.50...-..--....60........70..-.-...-.-.---80.-.-.......90........100.......110.......120.......130..-.....140.....-..150.......160.......170.......180.-....-..190........200.......210.......220.......230-.-...-.-..---240.-.---......250.......260.......270.......280.......290.......300....-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
K
T
--
A
F
L
F
AGQGA
Q
Y
LGMG
R
D
F
Y
DQYP
I
V
K
E
T
I
D
R
A
S
Q
V
LG
Y
D
-
L
R
-
Y
L
-
I
-DT-EED-KL--NQTRYTQ
P
A
I
L
A
T
S
V
A
I
Y
-
R
-
L
L
Q
-E-K---G-Y-Q-P
D
M
V
AGLSL
G
E
Y
S
A
L
V
ASGAL
D
F
E
D
A
V
A
L
V
A
KRGA
Y
M
EEAAPADSG
K
M
V
A
V
L-NT
P
V
E
V
I
E
E
A
C
Q
K
-
A
S
EL
G
V
VTPANYNT
P
A
Q
I
V
I
AG
E
V
V
A
V
D
R
A
V
E
L
L
Q
E-AGA
K
-
R
L
I
-
P
L
K
VSGPF
H
T
S
L
L
E
P
A
S
Q
K
L
A
E
T
L
A
Q
VSFSDFTCPLVGNT
E
A
-
A
-
V
M
Q
-
K
-
E
D
---
I
A
-
Q
-
L
---
L
T
R
Q
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
AGIS
N
F
I
EIG
P
G
K
V
L
S
G
F
V
K
K
I
D
QTA
H
L
A
H
V
E
D
Q
A
S
L
V
A
L
LEK-----
1
PsiBlast_PDB
89.59
100%
-121
- C1 -
-
3IM8
-
?
A:
[3-306]
--
K
T
--
A
F
L
F
A
G
Q
G
A
Q
Y
L
G
M
G
R
D
F
Y
D
Q
Y
P
I
V
K
E
T
I
D
R
A
S
Q
V
L
G
Y
D
-
L
R
-
Y
L
-
I
-
D
T
-
E
E
D
-
K
L
--
N
Q
T
R
Y
T
Q
P
A
I
L
A
T
S
V
A
I
Y
-
R
-
L
L
Q
-
E
-
K
---
G
-
Y
-
Q
-
P
D
M
V
A
G
L
S
L
G
E
Y
S
A
L
V
A
S
G
A
L
D
F
E
D
A
V
A
L
V
A
K
R
G
A
Y
M
E
E
A
A
P
A
D
S
G
K
M
V
A
V
L
-
N
T
P
V
E
V
I
E
E
A
C
Q
K
-
A
S
E
L
G
V
V
T
P
A
N
Y
N
T
P
A
Q
I
V
I
A
G
E
V
V
A
V
D
R
A
V
E
L
L
Q
E
-
A
G
A
K
-
R
L
I
-
P
L
K
V
S
G
P
F
H
T
S
L
L
E
P
A
S
Q
K
L
A
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T
L
A
Q
V
S
F
S
D
F
T
C
P
L
V
G
N
T
E
A
-
A
-
V
M
Q
-
K
-
E
D
---
I
A
-
Q
-
L
---
L
T
R
Q
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
A
G
I
S
N
F
I
E
I
G
P
G
K
V
L
S
G
F
V
K
K
I
D
Q
T
A
H
L
A
H
V
E
D
Q
A
S
L
V
A
L
L
E
K
-----
40
HHSearch
72.11
98%
1
- C1 -
-
3IM8
-
?
A:
[3-306]
--
K
T
--
A
F
L
F
A
G
Q
G
A
Q
Y
L
G
M
G
R
D
F
Y
D
Q
Y
P
I
V
K
E
T
I
D
R
A
S
Q
V
L
G
Y
D
-
L
R
Y
L
I
-
D
-
T
--
E
E
D
-
K
L
--
N
Q
T
R
Y
T
Q
P
A
I
L
A
T
S
V
A
I
Y
-
R
-
L
L
Q
-
E
-
K
---
G
-
Y
-
Q
-
P
D
M
V
A
G
L
S
L
G
E
Y
S
A
L
V
A
S
G
A
L
D
F
E
D
A
V
A
L
V
A
K
R
G
A
Y
M
E
E
A
A
P
A
D
S
G
K
M
V
A
V
L
-
N
T
P
V
E
V
I
E
E
A
C
Q
K
-
A
S
E
L
G
V
V
T
P
A
N
Y
N
T
P
A
Q
I
V
I
A
G
E
V
V
A
V
D
R
A
V
E
L
L
Q
E
-
A
G
A
K
-
R
L
I
-
P
L
K
V
S
G
P
F
H
T
S
L
L
E
P
A
S
Q
K
L
A
E
T
L
A
Q
V
S
F
S
D
F
T
C
P
L
V
G
N
T
E
A
-
A
V
M
Q
K
---
E
D
---
I
A
-
Q
-
L
---
L
T
R
Q
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
A
G
I
S
N
F
I
E
I
G
P
G
K
V
L
S
G
F
V
K
K
I
D
Q
T
A
H
L
A
H
V
E
D
Q
A
S
L
V
A
L
L
E
K
-----
16
PsiBlast_PDB
62.44
37%
-84
- C1 -
-
4RR5
-
FABD_SYNY3
A:
[2-284]
--
K
T
--
A
W
V
F
P
G
Q
G
S
Q
A
V
G
M
G
V
D
L
L
S
T
-
A
I
A
K
E
K
Y
Q
Q
A
E
E
I
L
G
W
S
-
V
V
-
E
K
-
C
-
Q
G
-
D
E
A
-
S
L
--
A
L
T
Q
N
T
Q
P
C
L
Y
V
I
E
A
I
L
A
-
D
-
L
L
R
-
D
-
K
---
G
-
F
-
Q
-
P
D
Y
V
A
G
H
S
L
G
E
Y
S
A
L
Y
A
A
G
V
F
D
F
A
T
G
L
Q
L
V
K
Q
R
S
E
V
M
---
A
S
A
S
G
G
M
M
A
A
L
M
-
K
F
D
Q
T
Q
L
Q
Q
A
L
T
D
-
N
T
E
---
V
V
L
A
N
D
N
S
P
E
Q
V
V
I
S
G
T
V
A
G
V
E
---
A
I
L
A
N
-
V
K
A
R
-
R
A
V
-
P
L
K
V
S
G
A
F
H
S
S
F
M
A
Q
P
S
Q
S
F
A
Q
T
L
T
A
C
H
F
N
D
A
T
V
P
V
L
S
N
V
D
P
-
S
-
P
T
Q
-
N
-
G
D
R
--
L
K
-
E
-
K
---
L
I
Q
Q
M
T
G
S
V
R
W
R
E
T
M
V
N
L
G
E
I
G
A
T
D
Y
W
E
V
G
P
G
K
V
L
T
G
L
C
K
R
T
C
P
D
L
N
L
K
N
I
-----------------
3
PsiBlast_PDB
58.88
45%
-13
- C1 -
-
1MLA
-
FABD_ECOLI
A:
[3-307]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
-
A
L
-
T
-
Q
Q
G
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
---
G
-
G
-
K
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
-
C
E
T
-
N
-
G
D
A
--
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
-------
4
PsiBlast_PDB
58.34
44%
-11
- C1 -
-
2G1H
1
FABD_ECOLI
A:
[2-307]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
-
A
L
-
T
-
Q
Q
G
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
---
G
-
G
-
K
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
-
C
E
T
-
N
-
G
D
A
--
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
------
45
HHSearch
58.29
45%
-10
- C1 -
-
1MLA
-
FABD_ECOLI
A:
[3-307]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
A
L
T
-
Q
-
Q
G
-
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
G--
G
-
K
-
A
-
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
C
E
T
N
-
G
-
D
A
---
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
-------
44
HHSearch
57.64
45%
-8
* C1 *
-
2G1H
1
FABD_ECOLI
A:
[2-307]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
A
L
T
-
Q
-
Q
G
-
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
G--
G
-
K
-
A
-
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
C
E
T
N
-
G
-
D
A
---
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
------
6
PsiBlast_PDB
57.55
44%
-11
- C1 -
-
2G2Y
-
FABD_ECOLI
A:
[2-306]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
-
A
L
-
T
-
Q
Q
G
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
---
G
-
G
-
K
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
-
C
E
T
-
N
-
G
D
A
--
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
-------
5
PsiBlast_PDB
57.24
44%
-8
- C1 -
-
2G2O
-
FABD_ECOLI
A:
[2-307]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
-
A
L
-
T
-
Q
Q
G
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
---
G
-
G
-
K
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
-
C
E
T
-
N
-
G
D
A
--
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
------
2
PsiBlast_PDB
57.08
47%
-
- C1 -
-
3PTW
-
?
A:
[2-307]
-
A
K
L
--
G
F
L
F
A
G
Q
G
A
Q
Y
V
G
M
G
K
E
F
F
D
N
F
E
E
S
K
E
V
F
K
R
S
S
E
A
L
G
I
D
-
M
E
-
E
L
C
F
-
N
D
-
P
E
G
-
L
L
--
N
K
T
E
F
T
Q
P
A
I
I
T
T
N
M
A
I
L
-
T
-
A
L
D
-
K
-
L
---
G
-
V
-
K
-
S
H
I
S
C
G
L
S
L
G
E
Y
S
A
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
Q
E
A
V
A
E
G
I
G
G
M
V
A
V
L
-
R
M
T
P
E
Q
V
D
E
I
I
E
K
-
S
S
P
Y
G
I
V
E
G
A
N
Y
N
S
P
G
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
E
-
V
G
G
--
R
A
I
-
K
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
K
I
S
I
N
K
L
N
G
I
V
M
S
N
V
K
G
E
A
-
Y
L
E
-
D
-
D
N
---
I
I
-
E
-
L
---
L
T
S
Q
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
S
G
V
D
T
F
I
E
I
G
P
G
K
A
L
S
G
F
V
K
K
I
N
K
N
V
T
V
L
N
V
E
D
L
K
S
L
E
K
T
L
S
K
-----
7
PsiBlast_PDB
56.83
44%
-14
- C1 -
-
2G2Z
2
FABD_ECOLI
A:
[2-307]
--
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
-
A
L
-
T
-
Q
Q
G
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
Y
-
R
-
V
W
Q
-
Q
-
Q
---
G
-
G
-
K
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
A
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
-
K
-
C
E
T
-
N
-
G
D
A
--
I
R
-
D
-
A
---
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
------
47
HHSearch
56.70
41%
-16
- C1 -
-
3K89
1
?
A:
[4-308]
-
S
T
L
--
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
-
L
W
A
L
S
-
Q
-
G
G
-
P
E
E
-
M
L
--
N
R
T
E
Y
T
Q
P
A
L
L
A
A
G
V
A
V
W
-
R
-
L
W
T
-
A
Q
R
---
G
-
Q
-
R
-
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
-
G
A
E
D
A
V
V
L
E
V
C
A
E
-
A
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
V
R
-
K
A
V
-
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
D
A
-
R
V
H
D
G
-
S
-
A
A
---
I
R
-
Q
-
A
---
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
A
T
P
A
D
Y
A
G
A
--------
32
HHSearch
56.11
48%
-
- C1 -
-
3PTW
-
?
A:
[2-295]
-
A
K
L
--
G
F
L
F
A
G
Q
G
A
Q
Y
V
G
M
G
K
E
F
F
D
N
F
E
E
S
K
E
V
F
K
R
S
S
E
A
L
G
I
D
-
M
E
E
L
C
-
F
-
N
D
-
P
E
G
-
L
L
--
N
K
T
E
F
T
Q
P
A
I
I
T
T
N
M
A
I
L
-
T
-
A
L
D
-
K
-
L
---
G
-
V
-
K
-
S
H
I
S
C
G
L
S
L
G
E
Y
S
A
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
Q
E
A
V
A
E
G
I
G
G
M
V
A
V
L
-
R
M
T
P
E
Q
V
D
E
I
I
E
K
-
S
S
P
Y
G
I
V
E
G
A
N
Y
N
S
P
G
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
E
-
V
G
G
--
R
A
I
-
K
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
K
I
S
I
N
K
L
N
G
I
V
M
S
N
V
K
G
-
E
A
Y
L
E
-
D
-
D
N
---
I
I
-
E
-
L
---
L
T
S
Q
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
S
G
V
D
T
F
I
E
I
G
P
G
K
A
L
S
G
F
V
K
K
I
N
K
N
V
T
V
L
N
V
-----------------
9
PsiBlast_PDB
55.99
45%
-11
- C1 -
-
3HJV
5
?
A:
[7-311]
-
S
K
F
--
A
I
V
F
P
G
Q
G
S
Q
A
V
G
M
L
A
D
L
A
E
Q
Y
A
V
V
K
Q
T
F
A
E
A
S
E
V
L
G
Y
D
-
L
W
-
A
L
-
V
Q
D
G
-
P
V
E
-
D
L
--
N
Q
T
F
R
T
Q
P
A
L
L
A
A
S
V
A
I
W
-
R
-
V
W
Q
-
Q
-
L
---
G
-
L
E
Q
-
P
A
V
L
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
K
Q
A
I
K
L
V
E
L
R
G
Q
L
M
Q
Q
A
V
P
A
G
T
G
A
M
Y
A
I
I
-
G
L
E
D
E
A
I
A
K
A
C
A
D
-
A
A
Q
G
E
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
Q
K
D
A
V
E
R
A
G
V
L
C
K
E
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
E
L
A
K
T
L
A
E
L
E
F
N
A
P
Q
I
P
V
I
N
N
V
D
----
V
V
A
-
E
-
T
D
P
V
K
I
K
-
D
-
A
---
L
I
R
Q
L
Y
S
P
V
R
W
T
E
C
V
E
Q
M
S
A
Q
G
V
E
K
L
I
E
-
G
P
G
K
V
L
T
G
L
T
K
R
I
V
K
T
L
E
G
V
A
V
N
D
V
A
S
L
D
A
V
--------
13
PsiBlast_PDB
55.28
42%
-5
- C1 -
-
3H0P
-
FABD_SALTY
A:
[5-312]
-
T
Q
F
--
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
A
E
M
A
A
N
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
-
L
W
-
A
L
-
T
-
Q
Q
G
P
A
E
-
E
L
--
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
A
L
W
-
R
-
V
W
Q
-
Q
-
Q
---
G
-
G
-
K
M
P
A
L
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
N
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
G
M
S
A
I
I
-
G
L
D
D
A
S
I
A
K
A
C
E
E
-
S
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
-
A
G
A
K
-
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
S
A
P
T
V
P
V
V
N
N
V
D
----
V
K
C
-
E
-
T
D
---
A
A
-
A
-
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
F
I
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
A
A
L
S
A
A
L
T
Q
-----
19
PsiBlast_PDB
54.22
36%
-29
- C1 -
-
3SBM
1
?
A:
[3-281]
------
A
Y
M
F
P
G
Q
G
S
Q
A
K
G
M
G
R
A
L
F
D
A
F
P
A
L
T
A
---
R
A
D
G
V
L
G
Y
S
-
I
R
-
A
L
-
C
-
Q
D
-
D
P
D
Q
R
L
--
S
Q
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
-
L
-
K
R
R
-
E
-
E
---
E
-
A
-
P
-
P
D
F
L
A
G
H
S
L
G
E
F
S
A
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
G
D
A
---
R
G
G
G
M
A
A
V
I
-
G
L
D
E
E
R
V
R
E
L
L
D
Q
-
N
G
A
T
A
V
D
I
-
A
N
L
N
S
P
S
Q
V
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
A
-
A
G
A
K
-
K
Y
T
-
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
G
Y
D
F
A
P
P
K
I
P
V
I
S
N
V
T
A
-
R
-
P
C
K
-
A
-
D
G
---
I
R
-
A
-
A
---
L
S
E
Q
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
M
G
R
G
V
E
E
F
V
E
C
G
H
G
I
V
L
T
G
L
Y
A
Q
I
R
R
D
A
----------------------
12
PsiBlast_PDB
53.90
40%
-2
- C1 -
-
3IM9
-
FABD_STAAM
A:
[10-304]
-
S
H
M
--
A
I
I
F
P
G
Q
G
A
Q
K
V
G
M
A
Q
D
L
F
N
N
N
D
Q
A
T
E
I
L
T
S
A
A
K
T
L
D
F
D
I
L
E
-
T
M
-
F
-
T
D
-
E
E
G
-
K
L
--
G
E
T
E
N
T
Q
P
A
L
L
T
H
S
S
A
L
L
-
A
-
A
L
----
K
---
N
-
L
-
N
-
P
D
F
T
M
G
H
S
L
G
E
Y
S
S
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
A
Q
A
F
P
T
G
V
G
S
M
A
A
V
L
-
G
L
D
F
D
K
V
D
E
I
C
K
S
L
S
S
D
D
K
I
I
E
P
A
N
I
N
C
P
G
Q
I
V
V
S
G
H
K
A
L
I
D
E
L
V
E
K
G
K
S
-
L
G
A
K
-
R
V
M
-
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
Q
F
E
W
R
D
A
K
F
P
V
V
Q
N
V
N
A
Q
G
-
E
T
D
-
K
-
E
V
---
I
K
-
S
-
N
---
M
V
K
Q
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
I
D
Q
G
V
D
H
F
I
E
I
G
P
G
K
V
L
S
G
L
I
K
K
I
N
R
D
V
K
L
T
S
I
Q
----------------
15
PsiBlast_PDB
53.88
42%
1
- C1 -
-
2CUY
-
?
A:
[3-301]
------
A
A
L
F
P
G
Q
G
S
H
R
V
G
M
G
R
A
L
Y
E
A
S
P
A
A
K
E
V
L
D
R
A
E
A
A
L
P
G
L
-
L
K
-
L
M
-
W
-
E
G
-
P
E
E
-
A
L
--
T
L
T
E
N
Q
Q
P
A
L
L
A
A
G
Y
A
A
Y
-
R
A
F
L
E
-
A
-
G
---
G
-
K
-
P
-
P
A
L
A
A
G
H
S
L
G
E
W
T
A
H
V
A
A
G
T
L
E
L
E
D
A
L
R
L
V
R
L
R
G
R
Y
M
Q
E
A
V
P
V
G
E
G
A
M
A
A
V
L
-
K
L
P
L
E
E
I
Q
K
A
L
E
G
----
L
E
G
V
E
I
A
N
L
N
A
P
E
Q
T
V
I
S
G
R
R
Q
A
V
E
E
A
A
E
R
L
K
E
-
R
R
A
--
R
V
V
-
F
L
P
V
S
A
P
F
H
S
S
L
M
A
P
A
R
K
R
L
A
E
D
L
A
Q
V
P
L
R
R
P
R
F
P
V
Y
S
N
V
T
A
-
R
-
P
E
E
D
P
-
E
R
---
I
R
-
A
-
L
---
L
L
E
Q
I
T
A
P
V
R
W
V
E
I
L
R
D
M
E
A
R
G
V
K
R
F
L
E
F
G
S
G
E
V
L
K
G
L
V
L
R
T
L
K
E
A
E
A
L
S
V
Q
D
P
D
S
L
R
K
A
L
E
------
11
PsiBlast_PDB
53.36
43%
-12
- C1 -
-
3R97
1
?
A:
[1-293]
M
T
E
S
T
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
-
L
W
-
A
L
-
S
-
Q
G
G
P
E
E
-
M
L
--
N
R
T
E
Y
T
Q
P
A
L
L
A
A
G
V
A
V
W
-
R
-
L
W
T
A
Q
-
R
---
G
-
Q
-
R
-
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
-
G
A
E
D
A
V
V
L
E
V
C
A
E
-
A
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
V
R
-
K
A
V
-
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
D
A
-
R
-
V
H
D
G
S
-
A
A
---
I
R
-
Q
-
A
---
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
-----------------------
8
PsiBlast_PDB
53.35
45%
-30
- C- -
-
3EZO
-
?
A:
[1-300]
--
K
F
--
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
N
A
F
A
D
-
V
A
V
V
R
E
T
L
D
E
A
S
D
A
L
G
Q
D
-
I
G
-
K
L
-
I
A
D
G
-
P
A
D
-
E
L
--
N
L
T
T
N
T
Q
P
V
M
L
T
A
A
Y
A
C
Y
-
R
-
A
W
Q
-
Q
-
A
---
G
G
A
-
Q
-
P
S
I
V
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
Q
T
A
V
P
V
G
V
G
G
M
A
A
I
L
-
G
L
D
D
D
T
V
R
A
V
C
A
E
-
A
S
A
T
G
V
V
E
A
V
N
F
N
A
P
A
Q
V
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
-
K
G
A
K
-
R
A
L
-
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
G
V
D
V
K
A
P
K
I
S
V
V
N
N
I
D
V
-
A
-
V
V
S
-
D
P
A
A
---
I
K
-
D
-
A
---
L
V
R
Q
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
A
R
E
G
V
T
H
V
I
E
C
G
P
G
K
V
L
A
G
L
T
K
R
I
D
G
N
L
V
G
A
S
V
F
D
P
A
S
L
-----------
10
PsiBlast_PDB
52.66
43%
-7
- C1 -
-
3K89
1
?
A:
[1-293]
M
T
E
S
T
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
-
L
W
-
A
L
-
S
-
Q
G
G
P
E
E
-
M
L
--
N
R
T
E
Y
T
Q
P
A
L
L
A
A
G
V
A
V
W
-
R
-
L
W
T
A
Q
-
R
---
G
-
Q
-
R
-
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
-
G
A
E
D
A
V
V
L
E
V
C
A
E
-
A
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
V
R
-
K
A
V
-
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
D
A
-
R
-
V
H
D
G
S
-
A
A
---
I
R
-
Q
-
A
---
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
-----------------------
22
PsiBlast_CBE
51.79
35%
-30
- C1 -
-
5DZ7
3
PKSE_BACSU
A:
[24-301]
-------
Y
V
F
P
G
Q
G
S
Q
Q
K
G
M
G
Q
G
L
F
E
Q
Y
---
Q
H
L
T
D
Q
A
D
Q
I
L
G
Y
S
-
I
E
-
K
L
-
C
--
T
-
E
K
S
-
Y
L
DV
N
H
T
E
Y
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
L
K
-
R
V
E
-
E
-
T
---
G
-
R
-
K
-
P
D
F
A
A
G
H
S
L
G
E
Y
N
A
L
M
A
A
G
A
F
D
F
E
T
G
L
R
L
V
K
K
R
G
E
L
M
G
R
I
T
---
G
G
G
M
A
A
V
I
-
G
L
S
K
E
Q
V
T
-
A
V
L
E
-
E
H
R
L
Y
D
I
D
V
A
N
E
N
T
P
Q
Q
I
V
I
S
G
P
K
K
E
I
E
K
A
R
A
V
F
E
N
-
T
K
D
V
-
K
L
F
H
P
L
N
V
S
G
A
F
H
S
R
Y
M
N
E
A
K
Q
V
F
K
Q
Y
I
D
S
F
Q
F
A
P
L
A
I
P
V
I
S
N
V
Y
A
-
E
-
P
Y
H
-
Q
-
D
R
---
L
K
-
D
-
T
---
L
S
E
Q
M
D
N
T
V
K
W
T
D
S
I
R
F
L
M
G
R
G
E
M
E
F
A
E
I
G
P
G
T
V
L
T
G
L
I
H
R
I
K
N
------------------------
14
PsiBlast_PDB
51.75
41%
-8
- C1 -
-
3TQE
3
?
A:
[9-298]
------
A
F
V
F
P
G
Q
G
S
Q
H
L
G
M
L
A
E
L
G
L
Q
Q
P
I
V
L
E
T
F
Q
Q
A
S
S
A
L
A
Y
D
-
L
W
-
A
L
-
V
-
Q
H
G
P
Q
E
-
R
L
--
D
Q
T
Q
F
T
Q
P
A
L
L
T
A
D
V
A
I
F
-
R
-
C
W
E
-
A
L
G
---
G
-
P
-
K
-
P
Q
V
M
A
G
H
S
L
G
E
Y
A
A
L
V
C
A
G
A
L
K
F
E
E
A
V
K
L
V
E
K
R
G
Q
Y
M
Q
E
A
V
P
V
G
E
G
A
M
G
A
I
I
-
G
L
N
E
A
E
I
E
S
I
C
E
N
-
A
A
L
G
Q
V
V
Q
P
A
N
L
N
S
T
D
Q
T
V
I
S
G
H
S
E
A
V
D
R
A
L
N
M
A
K
T
-
E
G
A
K
-
I
A
K
-
R
I
P
V
S
V
P
S
H
C
P
L
M
Q
P
A
A
D
R
L
A
Q
D
I
A
K
I
S
I
D
S
P
K
V
P
V
I
H
N
V
D
V
-
V
-
D
H
N
-
E
-
A
N
---
I
I
-
R
G
A
---
L
I
K
Q
L
V
R
P
V
R
W
V
E
T
I
K
Y
I
E
E
Q
G
I
K
V
F
M
E
C
G
P
D
N
K
L
A
G
L
I
K
R
I
D
R
Q
S
E
I
--------------------
20
PsiBlast_PDB
50.82
34%
-5
- C1 -
-
5DZ6
3
PKSC_BACSU
A:
[4-283]
-------
Y
V
F
P
G
Q
G
S
Q
K
Q
G
M
G
S
G
L
F
D
E
F
---
K
E
L
T
D
Q
A
D
E
I
L
G
Y
S
-
I
K
-
R
L
C
L
-
E
N
-
P
Y
S
-
N
L
--
N
K
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
L
K
-
K
I
R
-
D
-
E
---
E
-
V
-
K
-
P
D
F
V
A
G
H
S
L
G
E
Y
N
A
L
F
A
A
E
A
F
D
F
E
T
G
L
Q
L
V
R
K
R
G
E
L
M
---
S
L
I
S
N
G
G
M
A
A
V
M
-
G
L
N
E
E
Q
V
A
K
A
L
-
K
-
E
Y
H
L
H
D
V
D
I
A
N
V
N
A
P
Y
Q
I
V
I
S
G
K
K
D
E
I
E
K
A
A
S
L
F
E
T
M
T
E
V
T
-
M
V
L
-
P
L
N
V
S
G
A
F
H
S
R
Y
M
N
K
A
K
E
E
F
E
E
F
L
H
A
F
Y
F
S
P
P
S
I
P
V
I
S
N
V
Y
A
-
K
-
P
Y
T
-
Y
-
E
F
---
M
K
-
Q
-
T
---
L
A
D
Q
I
N
H
S
V
K
W
T
D
S
I
S
Y
L
M
K
K
A
A
M
E
F
E
E
V
G
P
G
N
V
L
T
G
L
I
H
R
I
K
K
D
A
----------------------
27
PsiBlast_CBE
48.90
33%
-103
- C1 -
-
4AMN
2
?
A:
[146-368]
------------------------------------------------------------------
D
T
A
V
A
Q
P
A
I
I
A
D
S
L
A
G
I
-
R
-
W
L
D
-
R
-
L
---
G
-
A
-
R
-
P
V
G
A
L
G
H
S
L
G
E
L
A
A
L
S
W
A
G
A
L
D
A
D
D
T
L
A
L
A
R
A
R
G
E
A
M
S
A
A
T
E
A
P
S
G
M
L
S
L
R
A
-
D
-----
L
A
A
A
R
E
L
-
A
A
G
T
G
A
V
V
-
A
V
D
N
G
E
R
H
V
V
V
A
G
T
R
P
E
L
D
R
V
A
E
A
A
R
H
-
A
G
I
E
--
A
T
-
P
L
A
V
S
H
A
F
H
S
P
L
M
A
P
A
A
E
A
L
R
R
A
A
G
R
L
P
W
R
R
P
E
R
P
V
A
S
T
V
T
G
-
A
-
W
W
A
-
D
-
E
D
---
P
V
-
E
-
V
---
L
V
R
Q
L
T
G
P
V
R
F
R
E
A
L
G
L
L
D
---
A
D
L
L
V
E
V
G
P
G
R
M
L
S
A
L
A
E
A
A
G
R
T
A
----------------------
29
PsiBlast_CBE
47.52
33%
-98
- C1 -
-
4AMO
2
?
A:
[146-368]
------------------------------------------------------------------
D
T
A
V
A
Q
P
A
I
I
A
D
S
L
A
G
I
-
R
-
W
L
D
-
R
-
L
---
G
-
A
-
R
-
P
V
G
A
L
G
H
S
L
G
E
L
A
A
L
S
W
A
G
A
L
D
A
D
D
T
L
A
L
A
R
A
R
G
E
A
M
S
V
A
T
E
A
P
S
G
M
L
S
L
R
A
-
D
-----
L
A
A
A
R
E
L
-
A
A
G
T
G
A
V
V
-
A
V
D
N
G
E
R
H
V
V
V
A
G
T
R
P
E
L
D
R
V
A
E
A
A
R
H
-
A
G
I
E
--
A
T
-
P
L
A
V
S
H
A
F
H
S
P
L
M
A
P
A
A
E
A
L
R
R
A
A
G
R
L
P
W
R
R
P
E
R
P
V
A
S
T
V
T
G
-
A
-
W
W
A
-
D
-
E
D
---
P
V
-
E
-
V
---
L
V
R
Q
L
T
G
P
V
R
F
R
E
A
L
G
L
L
D
---
A
D
L
L
V
E
V
G
P
G
R
M
L
S
A
L
A
E
A
A
G
R
T
A
----------------------
55
Fugue
47.09
31%
-4
- C1 -
-
1NM2
2
?
A:
[1-315]
-
H
M
L
--
V
L
V
A
P
G
Q
G
A
Q
T
P
G
F
L
T
D
W
L
A
L
-
P
G
A
A
D
R
V
A
A
W
S
D
A
I
G
L
D
-
L
A
-
H
F
-
G
T
K
A
-
D
A
D
-
E
I
--
R
D
T
S
V
A
Q
P
L
L
V
A
A
G
I
L
S
A
-
A
-
A
L
--
G
-
T
---
G
-
F
-
T
-
P
G
A
V
A
G
H
S
V
G
E
I
T
A
A
V
F
A
G
V
L
D
D
T
A
A
L
S
L
V
R
R
R
G
L
A
M
A
E
A
A
A
V
T
E
T
G
M
S
A
L
L
-
G
G
D
P
E
V
S
V
A
H
L
E
R
-
L
G
----
L
T
P
A
N
V
N
G
A
G
Q
I
V
A
A
G
T
M
E
Q
L
A
A
L
N
E
D
K
P
E
--
G
V
R
-
K
V
V
-
P
L
K
V
A
G
A
F
H
T
R
H
M
A
P
A
V
D
K
L
A
E
A
A
K
A
L
T
P
A
D
P
K
V
T
Y
V
S
N
K
D
G
-
R
-
A
V
A
S
G
-
T
E
---
V
L
-
D
-
R
---
L
V
G
Q
V
A
N
P
V
R
W
D
L
C
M
E
T
F
K
E
L
G
V
T
A
I
I
E
V
C
P
G
G
T
L
T
G
L
A
K
R
A
L
P
G
V
K
T
L
A
L
K
T
P
D
D
L
D
A
A
R
E
L
V
A
E
H
T
30
PsiBlast_CBE
42.18
31%
-18
- C1 -
-
2QC3
1
FABD_MYCTU
A:
[4-281]
------
A
L
L
A
P
G
Q
G
S
Q
T
E
G
M
L
S
P
W
L
-
Q
L
P
G
A
A
D
Q
I
A
A
W
S
K
A
A
D
L
D
-
L
A
-
R
L
-
G
-
T
T
A
S
T
E
-
E
I
--
T
D
T
A
V
A
Q
P
L
I
V
A
A
T
L
L
A
H
-
Q
-
E
L
A
-
R
-
R
CVL
A
-
G
-
K
-
D
V
I
V
A
G
H
S
V
G
E
I
A
A
Y
A
I
A
G
V
I
A
A
D
D
A
V
A
L
A
A
T
R
G
A
E
M
A
K
A
C
A
T
E
P
T
G
M
S
A
V
L
G
G
D
E
T
E
V
L
----
S
R
-
L
E
Q
L
D
L
V
-
P
A
N
R
N
A
A
G
Q
I
V
A
A
G
R
L
T
A
L
E
K
---
L
A
E
D
-
P
P
A
K
A
R
V
R
-
A
L
G
V
A
G
A
F
H
T
E
F
M
A
P
A
L
D
G
F
A
A
A
A
A
N
I
A
T
A
D
P
T
A
T
L
L
S
N
R
D
G
-
K
-
P
V
T
-
S
-
A
A
---
A
A
M
D
-
T
---
L
V
S
Q
L
T
Q
P
V
R
W
D
L
C
T
A
T
L
R
E
H
T
V
T
A
I
V
E
F
P
P
A
G
T
L
S
G
I
A
K
R
---------------------------
25
PsiBlast_CBE
40.97
32%
-4
- C1 -
-
1NM2
2
?
A:
[9-288]
-----------
G
Q
G
A
Q
T
P
G
F
L
T
D
W
L
-
A
L
P
G
A
A
D
R
V
A
A
W
S
D
A
I
G
L
D
-
L
A
-
H
F
G
T
-
K
A
-
D
A
D
-
E
I
--
R
D
T
S
V
A
Q
P
L
L
V
A
A
G
I
L
S
A
-
A
-
A
L
G
-
T
-----
G
-
F
-
T
-
P
G
A
V
A
G
H
S
V
G
E
I
T
A
A
V
F
A
G
V
L
D
D
T
A
A
L
S
L
V
R
R
R
G
L
A
M
A
E
A
A
A
V
T
E
T
G
M
S
A
L
L
-
G
G
D
P
E
V
---
S
V
A
H
-
L
E
R
L
G
-
L
T
P
A
N
V
N
G
A
G
Q
I
V
A
A
G
T
M
E
Q
L
-
A
A
L
N
E
D
K
P
-
E
G
V
R
-
K
V
V
-
P
L
K
V
A
G
A
F
H
T
R
H
M
A
P
A
V
D
K
L
A
E
A
A
K
A
L
T
P
A
D
P
K
V
T
Y
V
S
N
K
D
G
R
A
-
V
A
S
-
G
-
T
E
---
V
L
-
D
-
R
---
L
V
G
Q
V
A
N
P
V
R
W
D
L
C
M
E
T
F
K
E
L
G
V
T
A
I
I
E
V
C
P
G
G
T
L
T
G
L
A
K
R
---------------------------