@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0401: (2017-12-21 )
MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIYNFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRPGPVVIDLPKDISALETDFIYSSEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAGGGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTEADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQMLLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDVGQHQMWTAQYYPYQNERQLVTSDGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQMTNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70-........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......---.--190.--....---..-200.......210.......220..-......230.......240.......250.......260..-.....270.......280.......290.......300-------.---------........310.......320.......330.......340.------....-------..350.......-360-...-....----.370.......380..---..---...390.......400.......410.......420.......430.......440.......450.......460.......470.......480......--------.490.....-------....500.......510.......520...-....530--.-.-.......540.......550.......560....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEKISLESPKT
G
S
D
L
V
L
E
T
L
R
DLGVDTIFGYPGG
A
V
L
P
F
Y
D
A
I
YN
F
K
G
I
R
H
I
L
GRHEQGC
L
H
E
A
EGYAKST-GK
L
G
V
A
V
V
TSGPGA
T
N
A
I
T
G
I
A
D
A
MSDSV
P
L
L
V
F
TG
Q
V
A
RAGIG
K
D
A
FQEA
D
I
V
G
I
T
M
P
I
T
K
Y
N
Y
Q
VRETAD
I
P
R
I
I
T
E
A
V
H
I
ATTGRPG
P
V
V
I
DLPKD
I
S
A
L
E
T
D
F
I
YSSEVNLPS---Y--QPTL--EP
N
D
---
M
Q
-
I
K
K
I
L
K
Q
L
S
KAKK
P
V
L
L
AGGGI-
S
Y
-
A
E
A
A
T
E
L
N
E
F
A
E
R
YQI
P
V
V
T
S
L
LGQGTIATSH
P
L
F
L
GMGGM-HGS
F
A
A
N
I
A
MTE
A
D
F
M
I
S
IGSRFDDRLTGN
P
K
T
FAK---------N---------
A
K
V
A
H
I
DI
D
P
A
E
I
G
K
I
I
SADIPVVG
D
A
K
K
A
L
Q
M
L
LAEPTVHN------
N
T
E
K
-------
W
I
E
K
V
TK
D
K
N
R
V
-
R
S
--
Y
D
K
-
K
ERV----V
Q
P
Q
A
V
I
E
R
I
G
E
LTNG---
D
A
---
I
V
V
T
DVGQH
Q
M
W
T
A
QYYPYQNE
R
Q
L
VTSDGLGTMGFG
I
P
A
A
IGAKIANPD
K
E
V
V
L
F
VGDGG
F
Q
M
TNQ
E
L
A
I
L
N
I
Y
KV
P
I
K
V
V
M
LNNHS
L
G
M
V
R
Q
W
Q
E
S
F
YEG--------RT--S
E
S
V
F
-------DTL
P
D
F
Q
L
M
A
Q
AYGIKNYKFD
N
P
E
T
L
A
Q
D
L
-
E
V
I
T
E----D-V-
P
M
L
I
E
V
DISRKEQV
L
P
MVPAGKSNH
E
M
L
G
V
Q
FHA
4
PsiBlast_PDB
94.39
42%
-25
- C6 -
-
5K6T
4
ILVB_ARATH
A:
[3-576]
I
S
R
F
A
P
D
Q
P
R
K
G
A
D
I
L
V
E
A
L
E
R
Q
G
V
E
T
V
F
A
Y
P
G
G
A
S
M
E
I
H
Q
A
L
T
R
S
S
S
I
R
N
V
L
P
R
H
E
Q
G
G
V
F
A
A
E
G
Y
A
R
S
S
-
G
K
P
G
I
C
I
A
T
S
G
P
G
A
T
N
L
V
S
G
L
A
D
A
L
L
D
S
V
P
L
V
A
I
T
G
Q
V
P
R
R
M
I
G
T
D
A
F
Q
E
T
P
I
V
E
V
T
R
S
I
T
K
H
N
Y
L
V
M
D
V
E
D
I
P
R
I
I
E
E
A
F
F
L
A
T
S
G
R
P
G
P
V
L
V
D
V
P
K
D
I
Q
Q
Q
L
A
I
P
N
W
E
Q
A
M
R
L
P
G
---
Y
--
M
S
R
M
PK
P
P
E
D
---
S
H
-
L
E
Q
I
V
R
L
I
S
E
S
K
K
P
V
L
Y
V
G
G
G
C
----
L
N
S
S
D
E
L
G
R
F
V
E
L
T
G
I
P
V
A
S
T
L
M
G
L
G
S
Y
P
-
D
D
E
L
S
L
H
M
L
G
M
-
H
G
T
V
Y
A
N
Y
A
V
E
H
S
D
L
L
L
A
F
G
V
R
F
D
D
R
V
T
G
K
L
E
A
F
A
S
---------
R
---------
A
K
I
V
H
I
D
I
D
S
A
E
I
G
K
N
K
T
P
H
V
S
V
C
G
D
V
K
L
A
L
Q
G
M
--
N
K
V
L
E
N
------
R
A
E
E
LKLDF
G
V
W
R
N
E
L
N
V
Q
K
Q
K
F
P
L
S
--
F
K
T
-
F
G
E
A
----
I
P
P
Q
Y
A
I
K
V
L
D
E
L
T
D
G
---
K
A
---
I
I
S
T
G
V
G
Q
H
Q
M
W
A
A
Q
F
Y
N
Y
K
K
P
R
Q
W
L
S
S
G
G
L
G
A
M
G
F
G
L
P
A
A
I
G
A
S
V
A
N
P
D
A
I
V
V
D
I
D
G
D
G
S
F
I
M
N
V
Q
E
L
A
T
I
R
V
E
N
L
P
V
K
V
L
L
L
N
N
Q
H
L
G
M
V
M
Q
W
E
D
R
F
Y
K
A
--------
N
R
--
A
H
T
F
L
GDPAQED
E
I
F
P
N
M
L
L
F
A
A
A
C
G
I
P
A
A
R
V
T
K
K
A
D
L
R
E
A
I
-
Q
T
M
L
D
----
T
-
P
G
P
Y
L
L
D
V
I
C
P
H
Q
E
H
V
L
P
M
I
P
S
G
G
T
F
N
D
V
I
------
1
PsiBlast_PDB
93.76
42%
-24
- C6 -
-
5K2O
4
ILVB_ARATH
A:
[3-576]
I
S
R
F
A
P
D
Q
P
R
K
G
A
D
I
L
V
E
A
L
E
R
Q
G
V
E
T
V
F
A
Y
P
G
G
A
S
M
E
I
H
Q
A
L
T
R
S
S
S
I
R
N
V
L
P
R
H
E
Q
G
G
V
F
A
A
E
G
Y
A
R
S
S
-
G
K
P
G
I
C
I
A
T
S
G
P
G
A
T
N
L
V
S
G
L
A
D
A
L
L
D
S
V
P
L
V
A
I
T
G
Q
V
P
R
R
M
I
G
T
D
A
F
Q
E
T
P
I
V
E
V
T
R
S
I
T
K
H
N
Y
L
V
M
D
V
E
D
I
P
R
I
I
E
E
A
F
F
L
A
T
S
G
R
P
G
P
V
L
V
D
V
P
K
D
I
Q
Q
Q
L
A
I
P
N
W
E
Q
A
M
R
L
P
G
---
Y
--
M
S
R
M
PK
P
P
E
D
---
S
H
-
L
E
Q
I
V
R
L
I
S
E
S
K
K
P
V
L
Y
V
G
G
G
C
----
L
N
S
S
D
E
L
G
R
F
V
E
L
T
G
I
P
V
A
S
T
L
M
G
L
G
S
Y
P
-
D
D
E
L
S
L
H
M
L
G
M
-
H
G
T
V
Y
A
N
Y
A
V
E
H
S
D
L
L
L
A
F
G
V
R
F
D
D
R
V
T
G
K
L
E
A
F
A
S
---------
R
---------
A
K
I
V
H
I
D
I
D
S
A
E
I
G
K
N
K
T
P
H
V
S
V
C
G
D
V
K
L
A
L
Q
G
M
--
N
K
V
L
E
N
------
R
A
E
E
LKLDF
G
V
W
R
N
E
L
N
V
Q
K
Q
K
F
P
L
S
--
F
K
T
-
F
G
E
A
----
I
P
P
Q
Y
A
I
K
V
L
D
E
L
T
D
G
---
K
A
---
I
I
S
T
G
V
G
Q
H
Q
M
W
A
A
Q
F
Y
N
Y
K
K
P
R
Q
W
L
S
S
G
G
L
G
A
M
G
F
G
L
P
A
A
I
G
A
S
V
A
N
P
D
A
I
V
V
D
I
D
G
D
G
S
F
I
M
N
V
Q
E
L
A
T
I
R
V
E
N
L
P
V
K
V
L
L
L
N
N
Q
H
L
G
M
V
M
Q
W
E
D
R
F
Y
K
A
--------
N
R
--
A
H
T
F
L
GDPAQED
E
I
F
P
N
M
L
L
F
A
A
A
C
G
I
P
A
A
R
V
T
K
K
A
D
L
R
E
A
I
-
Q
T
M
L
D
----
T
-
P
G
P
Y
L
L
D
V
I
C
P
H
Q
E
H
V
L
P
M
I
P
S
G
G
T
F
N
D
V
I
------
2
PsiBlast_PDB
93.75
42%
-23
- C6 -
-
5K3S
3
ILVB_ARATH
A:
[3-576]
I
S
R
F
A
P
D
Q
P
R
K
G
A
D
I
L
V
E
A
L
E
R
Q
G
V
E
T
V
F
A
Y
P
G
G
A
S
M
E
I
H
Q
A
L
T
R
S
S
S
I
R
N
V
L
P
R
H
E
Q
G
G
V
F
A
A
E
G
Y
A
R
S
S
-
G
K
P
G
I
C
I
A
T
S
G
P
G
A
T
N
L
V
S
G
L
A
D
A
L
L
D
S
V
P
L
V
A
I
T
G
Q
V
P
R
R
M
I
G
T
D
A
F
Q
E
T
P
I
V
E
V
T
R
S
I
T
K
H
N
Y
L
V
M
D
V
E
D
I
P
R
I
I
E
E
A
F
F
L
A
T
S
G
R
P
G
P
V
L
V
D
V
P
K
D
I
Q
Q
Q
L
A
I
P
N
W
E
Q
A
M
R
L
P
G
---
Y
--
M
S
R
M
PK
P
P
E
D
---
S
H
-
L
E
Q
I
V
R
L
I
S
E
S
K
K
P
V
L
Y
V
G
G
G
C
----
L
N
S
S
D
E
L
G
R
F
V
E
L
T
G
I
P
V
A
S
T
L
M
G
L
G
S
Y
P
-
D
D
E
L
S
L
H
M
L
G
M
-
H
G
T
V
Y
A
N
Y
A
V
E
H
S
D
L
L
L
A
F
G
V
R
F
D
D
R
V
T
G
K
L
E
A
F
A
S
---------
R
---------
A
K
I
V
H
I
D
I
D
S
A
E
I
G
K
N
K
T
P
H
V
S
V
C
G
D
V
K
L
A
L
Q
G
M
--
N
K
V
L
E
N
------
R
A
E
E
LKLDF
G
V
W
R
N
E
L
N
V
Q
K
Q
K
F
P
L
S
--
F
K
T
-
F
G
E
A
----
I
P
P
Q
Y
A
I
K
V
L
D
E
L
T
D
G
---
K
A
---
I
I
S
T
G
V
G
Q
H
Q
M
W
A
A
Q
F
Y
N
Y
K
K
P
R
Q
W
L
S
S
G
G
L
G
A
M
G
F
G
L
P
A
A
I
G
A
S
V
A
N
P
D
A
I
V
V
D
I
D
G
D
G
S
F
I
M
N
V
Q
E
L
A
T
I
R
V
E
N
L
P
V
K
V
L
L
L
N
N
Q
H
L
G
M
V
M
Q
W
E
D
R
F
Y
K
A
--------
N
R
--
A
H
T
F
L
GDPAQED
E
I
F
P
N
M
L
L
F
A
A
A
C
G
I
P
A
A
R
V
T
K
K
A
D
L
R
E
A
I
-
Q
T
M
L
D
----
T
-
P
G
P
Y
L
L
D
V
I
C
P
H
Q
E
H
V
L
P
M
I
P
S
G
G
T
F
N
D
V
I
------
3
PsiBlast_PDB
93.61
42%
-22
- C6 -
-
5K6R
4
ILVB_ARATH
A:
[3-576]
I
S
R
F
A
P
D
Q
P
R
K
G
A
D
I
L
V
E
A
L
E
R
Q
G
V
E
T
V
F
A
Y
P
G
G
A
S
M
E
I
H
Q
A
L
T
R
S
S
S
I
R
N
V
L
P
R
H
E
Q
G
G
V
F
A
A
E
G
Y
A
R
S
S
-
G
K
P
G
I
C
I
A
T
S
G
P
G
A
T
N
L
V
S
G
L
A
D
A
L
L
D
S
V
P
L
V
A
I
T
G
Q
V
P
R
R
M
I
G
T
D
A
F
Q
E
T
P
I
V
E
V
T
R
S
I
T
K
H
N
Y
L
V
M
D
V
E
D
I
P
R
I
I
E
E
A
F
F
L
A
T
S
G
R
P
G
P
V
L
V
D
V
P
K
D
I
Q
Q
Q
L
A
I
P
N
W
E
Q
A
M
R
L
P
G
---
Y
--
M
S
R
M
PK
P
P
E
D
---
S
H
-
L
E
Q
I
V
R
L
I
S
E
S
K
K
P
V
L
Y
V
G
G
G
C
----
L
N
S
S
D
E
L
G
R
F
V
E
L
T
G
I
P
V
A
S
T
L
M
G
L
G
S
Y
P
-
D
D
E
L
S
L
H
M
L
G
M
-
H
G
T
V
Y
A
N
Y
A
V
E
H
S
D
L
L
L
A
F
G
V
R
F
D
D
R
V
T
G
K
L
E
A
F
A
S
---------
R
---------
A
K
I
V
H
I
D
I
D
S
A
E
I
G
K
N
K
T
P
H
V
S
V
C
G
D
V
K
L
A
L
Q
G
M
--
N
K
V
L
E
N
------
R
A
E
E
LKLDF
G
V
W
R
N
E
L
N
V
Q
K
Q
K
F
P
L
S
--
F
K
T
-
F
G
E
A
----
I
P
P
Q
Y
A
I
K
V
L
D
E
L
T
D
G
---
K
A
---
I
I
S
T
G
V
G
Q
H
Q
M
W
A
A
Q
F
Y
N
Y
K
K
P
R
Q
W
L
S
S
G
G
L
G
A
M
G
F
G
L
P
A
A
I
G
A
S
V
A
N
P
D
A
I
V
V
D
I
D
G
D
G
S
F
I
M
N
V
Q
E
L
A
T
I
R
V
E
N
L
P
V
K
V
L
L
L
N
N
Q
H
L
G
M
V
M
Q
W
E
D
R
F
Y
K
A
--------
N
R
--
A
H
T
F
L
GDPAQED
E
I
F
P
N
M
L
L
F
A
A
A
C
G
I
P
A
A
R
V
T
K
K
A
D
L
R
E
A
I
-
Q
T
M
L
D
----
T
-
P
G
P
Y
L
L
D
V
I
C
P
H
Q
E
H
V
L
P
M
I
P
S
G
G
T
F
N
D
V
I
------
5
PsiBlast_PDB
93.04
42%
-24
- C6 -
-
5K6Q
3
?
A:
[3-576]
I
S
R
F
A
P
D
Q
P
R
K
G
A
D
I
L
V
E
A
L
E
R
Q
G
V
E
T
V
F
A
Y
P
G
G
A
S
M
E
I
H
Q
A
L
T
R
S
S
S
I
R
N
V
L
P
R
H
E
Q
G
G
V
F
A
A
E
G
Y
A
R
S
S
-
G
K
P
G
I
C
I
A
T
S
G
P
G
A
T
N
L
V
S
G
L
A
D
A
L
L
D
S
V
P
L
V
A
I
T
G
Q
V
P
R
R
M
I
G
T
D
A
F
Q
E
T
P
I
V
E
V
T
R
S
I
T
K
H
N
Y
L
V
M
D
V
E
D
I
P
R
I
I
E
E
A
F
F
L
A
T
S
G
R
P
G
P
V
L
V
D
V
P
K
D
I
Q
Q
Q
L
A
I
P
N
W
E
Q
A
M
R
L
P
G
---
Y
--
M
S
R
M
PK
P
P
E
D
---
S
H
-
L
E
Q
I
V
R
L
I
S
E
S
K
K
P
V
L
Y
V
G
G
G
C
----
L
N
S
S
D
E
L
G
R
F
V
E
L
T
G
I
P
V
A
S
T
L
M
G
L
G
S
Y
P
-
D
D
E
L
S
L
H
M
L
G
M
-
H
G
T
V
Y
A
N
Y
A
V
E
H
S
D
L
L
L
A
F
G
V
R
F
D
D
R
V
T
G
K
L
E
A
F
A
S
---------
R
---------
A
K
I
V
H
I
D
I
D
S
A
E
I
G
K
N
K
T
P
H
V
S
V
C
G
D
V
K
L
A
L
Q
G
M
--
N
K
V
L
E
N
------
R
A
E
E
LKLDF
G
V
W
R
N
E
L
N
V
Q
K
Q
K
F
P
L
S
--
F
K
T
-
F
G
E
A
----
I
P
P
Q
Y
A
I
K
V
L
D
E
L
T
D
G
---
K
A
---
I
I
S
T
G
V
G
Q
H
Q
M
W
A
A
Q
F
Y
N
Y
K
K
P
R
Q
W
L
S
S
G
G
L
G
A
M
G
F
G
L
P
A
A
I
G
A
S
V
A
N
P
D
A
I
V
V
D
I
D
G
D
G
S
F
I
M
N
V
Q
E
L
A
T
I
R
V
E
N
L
P
V
K
V
L
L
L
N
N
Q
H
L
G
M
V
M
Q
W
E
D
R
F
Y
K
A
--------
N
R
--
A
H
T
F
L
GDPAQED
E
I
F
P
N
M
L
L
F
A
A
A
C
G
I
P
A
A
R
V
T
K
K
A
D
L
R
E
A
I
-
Q
T
M
L
D
----
T
-
P
G
P
Y
L
L
D
V
I
C
P
H
Q
E
H
V
L
P
M
I
P
S
G
G
T
F
N
D
V
I
------
27
PsiBlast_CBE
90.45
42%
-24
- C6 -
-
1T9D
7
ILVB_YEAST
B:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
-----------------------F
V
-
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
46
HHSearch
90.38
35%
-32
- C6 -
-
2PAN
10
GCL_ECOLI
F:
[25-584]
-------
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
I
T
T
A
F
G
V
P
G
A
A
I
N
P
F
Y
S
A
M
R
K
H
G
G
I
R
H
I
L
A
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
N
I
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
A
R
L
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
E
P
L
P
V
-------
Y
K
P
--
A
A
S
R
---
M
Q
-
I
E
K
A
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
-
I
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
H
E
L
M
A
G
M
V
G
L
Q
T
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
S
V
E
K
Y
T
E
---------
G
---------
R
K
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
KAGRLP
C
R
K
E
-------
W
V
A
D
C
Q
Q
R
K
R
T
L
-
L
R
K-
T
H
F
-
D
N
V
P
----
V
K
P
Q
R
V
Y
E
E
M
N
K
A
F
G
R
---
D
V
---
C
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
D
M
D
YCVQLAFE
N
I
NS
S
E
V
N
G
--------
Y
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
-
E
Q
A
K
A
LMAQ
Y
R
V
-
P
V
V
V
E
V
I
L
E
R
V
T
N
I
--------------------
9
PsiBlast_PDB
90.08
42%
-23
- C6 -
-
1T9B
7
ILVB_YEAST
A:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
-----------------------F
V
-
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
29
PsiBlast_CBE
89.87
42%
-14
- C6 -
-
1T9B
7
ILVB_YEAST
B:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
------------
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
26
PsiBlast_CBE
89.79
42%
-25
- C6 -
-
1T9D
7
ILVB_YEAST
C:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
----------------------------
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
28
PsiBlast_CBE
89.61
42%
-16
- C6 -
-
1T9C
5
ILVB_YEAST
B:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
---------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
31
PsiBlast_CBE
89.59
42%
-13
- C6 -
-
1N0H
7
ILVB_YEAST
B:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
---------
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
30
PsiBlast_CBE
89.57
42%
-15
- C6 -
-
1T9A
7
ILVB_YEAST
B:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
---------------
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
8
PsiBlast_PDB
89.49
42%
-12
- C6 -
-
1T9A
7
ILVB_YEAST
A:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
---------
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
12
PsiBlast_PDB
89.42
42%
-11
- C6 -
-
5FEM
6
ILVB_YEAST
A:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
--------
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RH
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
7
PsiBlast_PDB
89.09
42%
-15
- C6 -
-
1N0H
7
ILVB_YEAST
A:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
--------
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
24
PsiBlast_CBE
89.02
42%
-13
- C6 -
-
5FEM
6
ILVB_YEAST
B:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
--------
T
S
--
R
A
Q
D
EFV
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
EARRAAAEG
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RHV
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
10
PsiBlast_PDB
88.90
42%
-14
- C6 -
-
1T9C
5
ILVB_YEAST
A:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
---------
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
11
PsiBlast_PDB
88.53
42%
-14
- C6 -
-
1T9D
7
ILVB_YEAST
A:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
---------
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
25
PsiBlast_CBE
88.13
42%
-14
- C6 -
-
1T9D
8
ILVB_YEAST
D:
[83-655]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
---------
S
--
R
A
Q
D
EFV
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
EARRAAAEG
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RHV
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
44
HHSearch
87.60
43%
-9
* C6 *
-
5FEM
6
ILVB_YEAST
A:
[77-655]
----
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
----TS
R
A
Q
D
--
E
F
V
M
---
Q
S
-
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
-
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GR
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
-
P
Y
AY
M
E
E
T
P
G
S
K
----
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
GR
H
V
---
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
H
Q
--------
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
-
K
E
F
V
S
----
T
K
G
-
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
------
23
PsiBlast_CBE
86.81
42%
-17
- C6 -
-
5IMS
12
ILVB_YEAST
B:
[83-639]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
NAL
N
--
Q
L
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
PGSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RH
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
----------------------
22
PsiBlast_CBE
86.09
42%
-18
- C6 -
-
5INU
14
ILVB_YEAST
B:
[83-636]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
N
A
L
N
--
Q
L
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
AAEG
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
P
GSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RH
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
Y
E
H
--------
R
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
-------------------------
6
PsiBlast_PDB
85.73
42%
-13
- C6 -
-
1JSC
4
ILVB_YEAST
A:
[36-591]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
-------------
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
P
GSK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
R
H
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
--------------------------
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
-----------------------
21
PsiBlast_CBE
85.67
42%
-17
- C6 -
-
5INV
12
ILVB_YEAST
B:
[83-639]
----------
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
------
Q
L
T
S
--
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
EARRAAAEG
R
---------
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
-----
E
Y
--
P
--
Y
A
Y
-
M
E
E
T
P
G
S
K
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
---
T
G
RH
V
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
------------
Y
--
S
H
T
-
H
-------
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
V
S
T
----
K
-
G
-
P
V
L
L
E
V
E
V
D
K
K
V
----------------------
43
HHSearch
84.86
43%
-14
- C6 -
-
5INU
10
ILVB_YEAST
A:
[77-638]
----
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
G
G
A
I
L
P
V
Y
D
A
I
H
N
S
D
K
F
N
F
V
L
P
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
K
P
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
S
A
I
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S
---
N
TS
R
A
Q
D
--
E
F
V
M
---
Q
S
-
I
N
K
A
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
-
L
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
D
P
K
S
L
D
M
L
G
M
-
H
G
C
A
T
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
N
I
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GR
G
G
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
A
T
T
N
L
G
K
M
M
S
K
I
F
P
V
K
------
E
R
S
E
-------
W
F
A
Q
I
N
K
W
K
K
E
Y
-
P
Y
AY
M
E
E
T
P
G
S
K
----
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
TGR
H
V
---
I
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
--------------------------
S
H
T
H
Q
--------
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
-
K
E
F
V
S
----
T
K
G
-
P
V
L
L
E
V
E
V
D
K
K
-----------------------