@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0421: (2017-12-22 )
MMNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSLFLILISWPQEAFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPSAGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAEIYRMFIQRGITIKMPSGVPDVVSKSFSALLPGFTTFVLWALVLKGLEAAGVAGGLNGLLGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEAVAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFNINTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIGGFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK
Atome Classification :
(20 SA)
------------------.........10........-20.-------------------------------.....-..30......----------..40...--------...----.----.---50..-----......60.---..---.....70........80....--------------....90....--------------------....-100--......---------..110-......---------.120--..-...-.----..130-...-----..----...140-----....----....150--.........160--...-----..-....------170.......-------180---------....-.....190.....-.------.200.......210..---------.------------------....220.......230-.....----...240......----------.250.......260.-----------.-.....270......--------.280......------------------------.--290-------------------------....---.-....300......-----------.310------....---.--..320..-.....330-------...-......340.------......350.......----360.-----......370-----...-----...--...380--...-----------.....390-.--....---..400-........410-......---..------420.-----......430.......440-----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------M
M
N
N
I
L
A
F
L
E
T
K
VA
P
F
G
E
K-VG
N
-------------------------------
Q
R
H
L
K
-
A
I
R
E
G
F
M
M
A
M
----------
P
L
I
L
V
G
S
--------
L
F
L
----
I
----L---ISW
P
-----
Q
E
A
F
T
N
W
L
N
---
S
V
---
G
L
L
S
I
L
T
TMN
Q
S
T
V
A
I
I
S
L
V
A
--------------
C
F
G
I
A
Y
R
LSE--------------------GYGT-DG---PS
A
G
I
I
---------
A
L
S
S
F
-
V
LMAP
R
---------
F
S
S
---MV-YDK-
N
----
G
E
Q
V
--
K
Q
L
-----FG----GAIPF------SSLN----AS
S
L
F
----
M
A
I
T
I
G
L
V
T
A
----
E
I
Y
-----
R
M
-
F
I
QR------G
I
T
I
KMPSG
V
-------
P
-----------
D
V
V
S
-
K
S
F
S
A
LL
P
G
F
T
T
F
-
V
------
L
W
A
L
V
L
K
G
L
E
A
AGVA
G
---------
G
------------------
L
N
G
L
L
G
A
I
VG
T
P
L
K
L
I
--
A
GTL
P
----
G
M
I
L
C
V
I
V
N
S
F
F
----------
W
F
CGVNG
G
Q
V
L
N
A
FV-----------D-
P
V
W
L
Q
F
TTEN
Q
E
A
V
--------AA
G
Q
T
L
Q
H
I
I
------------------------T--L---------------------------PFK
D
---
L
-
F
V
F
IGGG
G
A
T
I
G
L
-----------
A
I
C
L
------
F
L
FS---K--SRANKTL-G
K
L
A
I
I---------
P
S
I-FNI
N
T
A
I
L
F
T------
F
P
T
VLNP
I
M
L
I
PFIAT----
P
T
I
N
-----
A
L
I
T
Y
V
S
-------
M
A
V-----GLV--PYTTG---VIL-----------PWTM
P
P
I
I
-
G
--
G
F
LA---TGA
S
--
W
R
G
A
L
L
Q
V
V
L
--
I
L
V
S
V
A
---
I
Y
------
Y
P
F
F
-----
K
IADKRN
L
E
K
E
KATVGGK------------------------------------------------------------------------------------------------------------------
20
Fugue
85.93
36%
-156
- C5 -
-
3QNQ
8
?
A:
[3-434]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
---
S
L
FGK
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
-----------
F
Q
---
V
A
-
Y
I
M
-
P
----
G
T
K
E
--
S
I
L
-----
V
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
-
T
------
V
V
W
I
I
R
L
I
F
E
H
T
T
-
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
A
E
E
K
G
E
A
---------------------------------------------------------------------------------------------------------------------
10
HHSearch
85.15
36%
-142
- C5 -
-
3QNQ
7
?
D:
[3-437]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
SLF
G
K
---
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
----------
F
Q
V
---
A
Y
I
M
P
G
-
T
----
K
E
S
I
--
L
V
-------
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
-
T
------
V
V
W
I
I
R
L
I
F
E
-
H
T
T
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
A
E
E
K
G
E
A
A
A
E
------------------------------------------------------------------------------------------------------------------
11
HHSearch
84.69
36%
-141
- C5 -
-
3QNQ
8
?
A:
[3-434]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
S
L
F
G
K
---
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
----------
F
Q
V
---
A
Y
I
M
P
G
-
T
----
K
E
S
I
--
L
V
-------
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
-
T
------
V
V
W
I
I
R
L
I
F
E
-
H
T
T
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
A
E
E
K
G
E
A
---------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
84.16
35%
-141
- C5 -
-
3QNQ
7
?
B:
[3-427]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
---
S
L
FGK
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
-----------
F
Q
---
V
A
-
Y
I
M
-
P
----
G
T
K
E
--
S
I
L
-----
V
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
------
V
W
--
I
I
R
L
I
F
E
H
T
T
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
83.47
35%
-148
- C5 -
-
3QNQ
9
?
C:
[3-427]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
---
S
L
FGK
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
-----------
F
Q
---
V
A
-
Y
I
M
-
P
----
G
T
K
E
--
S
I
L
-----
V
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
------
V
W
--
I
I
R
L
I
F
E
H
T
T
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
----------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_CBE
83.39
35%
-147
- C5 -
-
3QNQ
7
?
D:
[3-427]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
---
S
L
FGK
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
-----------
F
Q
---
V
A
-
Y
I
M
-
P
----
G
T
K
E
--
S
I
L
-----
V
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
------
V
W
--
I
I
R
L
I
F
E
H
T
T
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.26
35%
-145
- C5 -
-
3QNQ
8
?
A:
[3-427]
------------------------
R
F
L
E
K
Y
V
M
P
V
A
G
K
-
V
A
E
-------------------------------
Q
R
H
L
L
-
A
I
R
D
G
L
V
L
T
M
----------
P
F
L
I
I
G
S
--------
I
F
L
----
I
----
I
---
S
T
L
P
-----
I
P
G
Y
S
E
F
M
A
---
S
L
FGK
N
W
N
V
A
L
G
Y
P
V
S
A
T
F
N
I
M
A
L
I
A
--------------
V
F
G
I
A
Y
R
L
G
E
--------------------
Y
Y
K
V
-
D
A
---
L
A
S
G
A
L
---------
S
L
V
T
F
-
L
L
A
T
P
-----------
F
Q
---
V
A
-
Y
I
M
-
P
----
G
T
K
E
--
S
I
L
-----
V
D
----
G
V
I
P
A
------
A
L
M
G
----
S
Q
G
L
F
----
V
A
M
I
I
A
I
I
S
T
----
E
I
Y
-----
R
F
-
L
V
Q
K
------
K
M
I
I
K
M
P
E
T
V
-------
P
-----------
P
A
V
T
-
R
S
F
A
A
L
I
P
G
F
I
V
V
T
V
------
V
W
--
I
I
R
L
I
F
E
H
T
T
F
G
---------
S
------------------
I
H
N
V
V
G
K
L
L
Q
E
P
L
S
I
L
--
G
A
S
L
W
----
G
A
V
I
A
V
I
L
V
H
V
L
----------
W
A
C
G
I
H
G
A
T
I
V
G
G
V
M
-----------
S
-
P
I
W
L
S
L
M
D
Q
N
R
I
A
F
--------
Q
A
G
Q
D
V
P
N
T
I
------------------------
T
--
A
---------------------------
Q
F
F
D
---
L
-
W
I
Y
M
G
G
S
G
A
T
L
A
L
-----------
V
V
G
M
------
L
L
F
A
---
R
--
S
Q
Q
L
K
S
L
-
G
R
L
S
I
A
---------
P
G
I
-
F
N
I
N
E
M
V
T
F
G
------
M
P
I
V
M
N
P
L
L
L
I
P
F
I
V
V
----
P
V
V
L
-----
T
I
V
S
Y
F
A
-------
M
E
W
-----
G
L
V
--
A
R
P
S
G
---
A
A
V
-----------
T
W
T
T
P
I
L
F
-
S
--
G
Y
L
G
---
S
G
G
K
--
I
S
G
V
I
L
Q
L
V
N
--
F
A
L
A
F
V
---
I
Y
------
L
P
F
L
-----
K
I
W
D
K
Q
K
I
----------------------------------------------------------------------------------------------------------------------------
25
Fugue
49.27
17%
-23
- C5 -
-
4Z13
6
?
A:
[3-519]
-------------------
L
A
P
I
T
A
P
D
I
T
S
I
C
K
D
A
S
S
G
I
G
N
-------------------------------
Q
E
G
A
I
-
R
T
R
K
C
C
P
P
S
L
----------
G
K
K
I
K
D
F
--------
Q
F
P
NDKK
V
----
R
---
M
R
W
P
AHKGT
K
K
Q
V
D
D
Y
R
R
---
A
I
---
A
A
M
R
A
L
P
D
D
D
P
R
S
F
V
S
Q
A
K
I
H
--------------
C
A
Y
C
----
N
G
--------------------
G
Y
T
Q
-
V
D
SGF
P
D
I
D
I
Q
---------
I
H
N
S
W
L
F
F
P
F
H
R
---------
W
Y
L
---
Y
F
-
Y
E
R
-
I
----
L
G
S
L
--
I
D
E
-----
P
N
----
F
A
L
P
Y
WKWDEP
K
G
M
P
----
I
S
N
I
F
----
L
----
G
D
A
S
N
----
P
L
Y
DQYRD
A
N
-
H
I
E
D
------
R
I
V
D
L
D
Y
D
G
K
-------
D
-----------
K
--
D
-
I
P
D
Q
Q
Q
V
A
C
N
L
S
T
-
V
------
Y
R
D
L
V
R
N
G
V
D
P
T
S
F
F
G
---------
G
K
Y
V
A
GDSPDP
S
V
G
S
V
E
A
G
S
H
T
A
V
H
R
W
V
G
D
P
T
Q
P
N
--
N
E
D
M
-----
G
N
F
Y
S
A
G
Y
D
P
V
F
----------
Y
I
H
H
A
N
V
D
R
M
W
K
L
W
K
E
L
RLPGHVDIT
D
-
P
D
W
L
N
A
S
Y
V
F
Y
D
E
N
--------
K
D
L
V
R
V
Y
N
K
D
------------------------
C
--
V
---------------------------
N
L
D
K
---
L
K
Y
N
F
I
E
N
S
K
E
V
------------------------
F
P
W
R
---
N
--
S
R
P
P
Q
R
--
R
K
S
A
Q
V
---------
A
T
T
-
G
D
V
K
T
V
E
Q
T
K
------
F
P
V
R
L
N
Q
I
F
K
V
R
V
K
-
R
----
P
A
V
N
RT
E
E
E
K
D
Q
A
N
E
V
-------
L
L
I
-----
K
K
I
--
K
Y
D
S
G
K
F
V
K
F
D
-----------
V
F
V
N
D
K
L
K
-
D
--
G
V
F
T
---
T
P
C
D
PE
Y
A
G
G
F
A
Q
I
P
H
ND
V
M
T
S
T
A
---
R
F
------
G
L
N
E
-----
L
L
E
D
T
N
T
E
G
E
E
Y
A
T
V
T
L
V
P
RTGCED
L
T
V
G
E
I
K
I
E
L
V
P
IPK--------------------------------------------------------------------------------------------
21
Fugue
48.40
18%
-34
- C5 -
-
4IUW
2
?
A:
[4-633]
---------LPRIQDD
L
Y
L
A
V
N
G
E
W
Q
A
K
T
P
I
P
P
D
K
S
V
-
V
S
A
-------------------------------
D
S
N
L
T
D
D
I
R
Q
K
L
V
A
D
L
S
T
M
T
KTAKT
L
P
L
Q
Y
A
A
R
--------
L
F
A
----
K
----
A
N
D
Q
T
R
R
Q
-----
Q
L
G
I
E
P
V
R
D
---
R
I
---
S
F
L
M
A
L
T
T
L
D
Q
F
R
S
A
M
P
K
L
V
A
D
QYVLP
I
S
P
Y
V
D
A
D
M
H
D
A
E
H
N
I
L
N
--------------------
L
G
G
P
-
D
T
IL-
P
D
A
A
M
Y
N
Q
ED
A
E
N
A
A
D
L
A
A
W
-
S
Q
M
A
A
A
---------
M
L
A
---
A
V
--
G
F
-
S
----
Q
T
D
Q
--
T
A
Y
-----
V
E
----
A
A
K
R
F
------
D
R
R
L
----
A
D
Y
V
P
----
A
N
V
D
L
A
V
D
S
T
YD
N
P
L
S
W
-----
Q
A
-
F
E
D
A
------
A
G
Y
L
G
I
P
Q
A
F
A
T
Y
MPQT
P
-----------
A
K
V
N
-
A
V
V
P
A
Y
L
P
H
L
S
K
L
-
L
TPDN
Y
S
E
W
H
A
W
M
V
I
N
E
L
L
T
C
A
T
---------
Y
------------------
L
S
D
D
L
R
Q
L
A
G
Q
Y
D
R
F
L
--
A
G
Q
P
E
ASS
W
T
K
H
A
F
G
I
A
N
E
Y
F
D
D
V
I
G
Q
Y
Y
G
Q
T
Y
F
G
A
D
A
K
A
D
V
T
A
M
V
-----------
K
-
Q
I
L
A
Q
Y
R
V
Q
L
E
N
N
T
--------
W
L
S
P
A
T
K
Q
K
A
------------------------
M
--
R
---------------------------
K
L
A
T
---
M
-
Q
V
K
M
G
Y
P
A
R
L
F
S
L
-----------
Y
D
H
L
------
S
V
D
V
---
D
--
D
D
L
L
T
A
I
-
L
K
L
S
A
Q
---------
T
Q
A
-
F
W
F
K
Q
---
L
G
------
Q
T
V
D
R
N
Q
W
N
M
P
G
H
L
V
N
----
A
S
Y
D
-----
P
L
K
N
D
I
T
-------
F
P
A
-----
G
I
L
QP
P
Y
Y
S
------
L
-----------
K
W
T
R
A
E
N
L
-
G
--
G
------
T
G
A
T
--
I
G
H
E
I
S
H
S
F
D
----
N
N
G
A
---
L
Y
DEYGNL
H
N
W
W
-----
T
P
A
D
K
Q
A
F
D
Q
L
V
K
A
M
A
A
Q
F
DGRDYEG
V
K
V
N
GTLT
V
S
E
N
M
A
D
N
A
G
M
D
V
A
L
A
L
L
GDQPD
V
K
D
L
Q
A
F
F
I
T
Y
A
R
S
W
A
T
K
M
R
P
E
R
A
K
T
V
L
R
QDVHAP
A
T
L
R
V
N
V
P
V
Q
N
F
P
A
W
Y
Q
A
F
NVQPQDGMYRQPQK
R
L
T
I
WHQ
12
HHSearch
45.39
11%
-113
- C5 -
-
5IWS
1
?
A:
[6-446]
--------------------------------------------------------------------------
F
W
Q
-
K
F
G
K
A
L
L
V
V
V
----------
A
V
M
P
A
A
G
--------
L
M
I
----
S
----
I
---
G
K
L
I
-----
G
M
S
A
G
D
I
N
A
---
V
H
---
T
I
A
R
V
M
E
D
I
G
W
A
I
I
T
N
L
H
I
L
F
--------------
A
V
A
I
G
G
S
W
A
K
--------------------
D
-
R
A
-
G
------
G
A
F
A
---------
A
L
L
A
F
-
V
L
T
N
R
----------
I
T
G
---
A
I
-
F
G
V
N
A
E
M
L
A
D
S
K
A
K
V
S
S
V
-----
L
A
GDLI
V
K
D
Y
F
T
-----
S
V
L
G
A
P
A
L
N
M
G
V
F
----
V
G
I
I
T
G
F
L
G
A
----
T
L
Y
-----
N
K
-
Y
Y
N
-------
Y
--
N
K
L
P
Q
A
L
-------
A
-----------
F
F
N
G
-
K
R
F
V
P
F
V
V
I
V
W
S
T
-
V
------
T
A
I
V
L
S
L
L
---
W
---
P
---------
F
------------------
I
Q
S
G
L
N
E
F
G
-
R
W
I
A
A
S
KD
S
A
P
I
V
----
A
P
F
V
Y
G
T
L
E
R
L
L
----------
L
P
F
G
L
H
H
M
L
T
-
I
P
M
----------------
N
Y
T
E
L
G
G
T
Y
T
M
L
TGSKVG
Q
V
V
A
G
Q
D
P
--
L
W
------------------------
L
--
A
W
I
T
D
L
N
N
L
L
A
N
GD
T
K
A
Y
N
D
L
L
N
N
V
VPA
R
F
K
A
G
Q
V
I
-
G
S
T
A
A
L
M
G
I
A
F
---------------
A
M
------
F
R
N
V
DKE
K
--
R
A
K
Y
K
P
M
-
F
L
S
A
A
L
---------
A
V
F
L
T
G
V
T
E
P
I
E
F
M
------
F
M
F
I
-
A
P
V
L
---
Y
V
V
Y
----
A
I
T
T
-----
G
L
A
F
A
L
A
-------
D
L
I
-----
N
L
R
--
V
H
A
--------------------
F
G
F
I
E
L
I
T
R
T
P
M
M
V
N
A
GL
T
R
D
L
--
I
N
F
V
I
V
S
L
V
F
--
F
G
L
N
F
T
---
L
F
------
N
F
L
I
-----
K
K
F
N
L
P
T
P
G
R
A
G
------------------------------------------------------------------------------------------------------------------------
23
Fugue
43.89
18%
-86
- C5 -
-
5T9J
10
GEN_HUMAN
A:
[2-467]
------------------
G
V
N
D
L
W
Q
I
L
E
--------
P
-
V
K
Q
-------------------------------
H
I
P
L
R
-
N
L
G
G
K
T
I
A
V
N
----------
L
S
L
W
V
C
E
--------
A
Q
T
----
V
----
K
---
K
M
M
G
-----
S
V
M
K
P
H
L
R
N
---
L
F
---
F
R
I
S
Y
L
T
Q
M
D
V
K
L
V
F
V
M
E
-------------------
G
E
P
P
K
L
Q
T
--------------------
R
Y
G
S
-
S
G
---
K
S
W
S
Q
K
---------
T
G
R
S
H
-
F
K
S
V
L
R
---------
E
C
L
---
H
M
-
L
E
C
-
L
----
G
I
P
W
--
V
Q
A
-----
A
G
----
E
A
E
A
M
C
-----
A
Y
L
N
----
A
G
G
H
V
----
D
G
C
L
T
N
D
G
D
T
----
F
L
Y
-----
G
A
Q
T
V
Y
R
------
N
F
T
M
N
T
K
D
P
H
-------
V
-----------
D
C
Y
T
-
M
S
S
I
K
S
K
L
G
L
D
R
D
-
A
------
L
V
G
L
A
I
L
L
----
G
C
D
Y
---------
L
------------------
P
K
G
V
P
G
V
G
K
E
Q
A
L
K
L
I
--
Q
I
---------------------------------
L
K
G
Q
S
L
L
Q
R
F
N
-----------
R
W
N
N
E
V
E
N
N
I
K
K
K
A
C
C
--------
C
E
G
F
P
F
H
E
V
I
------------------------
Q
E
F
L
---------------------------
L
N
K
D
---
K
-
L
V
K
V
I
R
Y
Q
R
P
D
L
L
-----------
L
F
Q
R
------
F
T
L
E
---
K
ME
W
P
N
H
Y
A
C
-
E
K
L
L
V
L
---------
L
T
H
-
Y
D
M
I
E
R
K
L
G
S
R-----
N
S
N
Q
L
Q
P
I
R
I
V
K
T
R
I
R
----
N
G
------------------------------------
V
H
C
---
F
E
I
-----------
E
W
E
K
P
E
---
H
--
Y
A
M
E
---
D
K
Q
H
--
G
E
F
A
L
L
T
I
E
E
--
E
S
L
F
E
A
---
A
Y
------
P
E
I
V
-----
A
V
Y
Q
K
Q
K
L
E
I
K
G
K
K
----------------------------------------------------------------------------------------------------------------------
29
Fugue
41.03
16%
-34
- C3 -
-
3J9O
-
?
B:
[79-505]
------------------
V
I
D
K
L
I
D
L
Q
V
N
S
I
I
S
N
D
E
F
-
R
A
L
-------------------------------
E
Q
E
W
L
-
K
V
Q
E
V
C
Q
E
D
Y
----------
D
N
V
E
V
S
I
--------
L
----------------
D
V
K
-----
K
E
E
L
Q
Y
D
F
E
---
R
----
N
L
Y
D
I
S
S
S
D
F
F
K
K
V
Y
V
S
E
F
D
Q
--------------
Y
G
G
E
P
Y
G
A
I
L
--------------------
G
L
Y
N
F
E
N
---
T
T
N
D
I
I
---------
W
L
T
G
M
-
G
M
V
A
K
N
---------
S
H
A
P
F
I
A
S
-
I
D
K
-
S
FFG-
V
K
D
L
--
S
E
I
THIKS
F
E
----
A
L
L
E
H
------
P
R
Y
K
----
E
W
N
D
F
R
N
LD
V
A
A
Y
I
G
L
T
V
G
----
D
F
-------
M
-
L
R
Q
P
YNPENN
P
V
Q
Y
K
L
M
E
G
F
-------
N
-----------
E
F
V
D
Y
D
K
N
E
S
Y
L
W
G
P
A
S
I
-
H
------
L
V
K
N
M
M
R
S
Y
D
K
T
R
W
F
Q
---------
Y
------------------
I
R
G
V
E
S
G
------------
G
Y
V
K
----
N
L
V
A
C
V
Y
---------------------
D
N
K
G
I
L
E
T
K
-----------
S
-
P
L
N
V
L
F
------
A
D
--------
Y
M
E
L
S
L
A
N
I
G
------------------------
L
--
I
---------------------------
P
F
--------
V
S
E
K
G
T
S
N
A
C
F
F
-----------
S
V
N
S
AKKVEE
F
V
D
G
---
F
--
D
S
A
N
S
R
L
I
A
N
L
S
Y
T
---------
M
C
I
-
S
R
I
S
H
Y
I
K
C
V
------
I
R
D
K
I
G
S
I
V
D
V
E
S
I
Q
K
----
I
L
S
D
-----
W
I
S
E
F
V
T
TVYQPTP
L
E
M
-----
A
R
Y
--
P
F
R
N
V
---
S
I
E
-----------
V
K
T
I
P
G
--------------
K
P
G
--
W
Y
S
C
K
I
N
V
I
P
--
H
--------
I
Q
------
F
E
G
M
-----
N
T
T
M
T
I
D
T
R
L
E
P
E
L
F
G
T
N
N-----------------------------------------------------------------------------------------------------------------
28
Fugue
38.56
11%
-130
- C4 -
-
2HQY
1
?
A:
[1-298]
-------------------------
M
I
P
F
K
D
I
T
L
A
D
R
-
D
T
I
-------------------------------
T
A
F
T
M
-
K
--------
S
----------
D
R
R
N
C
D
L
--------
S
F
S
----
N
----
L
---
C
S
W
R
-----
F
L
Y
D
T
Q
F
A
V
---
I
D
---
D
F
L
V
F
K
F
W
A
G
E
Q
L
A
Y
M
M
P
V
----------------------------------------------
G
N
G
D
-
L
K
---
A
V
L
R
K
L
---------
I
E
D
A
D
-
K
E
K
H
N
F
---------
C
M
L
---
G
V
-
C
S
N
-
M
----
R
A
D
L
--
E
A
I
-----
L
P
----
E
R
F
I
F
------
T
E
D
R
----
A
Y
A
D
Y
----
I
Y
L
R
S
D
L
A
T
L
----
K
G
K
-----
K
F
-
Q
A
K
R
------
N
H
I
N
R
F
R
N
T
Y
-------
P
-----------
D
Y
E
Y
-
T
P
----
I
T
P
D
R
I
Q
-
E
------
C
L
D
L
E
A
E
W
C
K
V
N
N
C
D
Q
---------
Q
-----------------------------------------------------------------------------------------------------
E
G
T
G
N
E
R
R
--------
A
L
I
Y
A
L
H
N
F
E
------------------------
A
--
L
---------------------------
G
L
T
G
---
G
-
I
L
H
V
N
G
--
K
I
V
A
F
-----------
T
F
G
M
------
P
I
N
H
---
E
-------------
T
F
G
---------
V
H
V
-
E
K
A
D
T
S
I
D
G
A
------
Y
A
M
I
N
Y
E
F
A
N
R
I
P
E
Q
Y
----
I
Y
I
N
--------------------------------------------------------------------------------
R
E
E
D
L
G
I
E
G
--
L
R
K
A
K
L
---
S
Y
------
Q
P
-----------
V
T
I
L
E
K
Y
M
A
C
L
K
D
H
------------------------------------------------------------------------------------------------------------------
24
Fugue
34.93
10%
-31
- C5 -
-
3NB0
6
GYS2_YEAST
A:
[22-659]
SRDLQ
N
H
L
L
F
E
T
A
TEVAN
R
V
G
G
I
Y
S
V
L
K
S
K
A
P
I
T
V
A
Q
-
Y
K
D
H
Y
H
L
I
G
P
L
NKATYQNEVDILDWKKPEAFSDE
M
R
P
V
Q
-
H
A
L
Q
T
M
E
S
R
G
----------
V
H
F
V
Y
G
R
W
LIEGA
P
K
V
I
L
----
F
D
LDS
V
---
R
G
Y
S
-----
N
E
W
K
G
D
L
W
S
---
L
V
---
G
I
P
S
P
E
N
D
F
E
T
N
D
A
I
L
L
G
Y
T
V
--------------
A
W
F
L
G
E
V
A
H
L
DSQ
H
A
I
V
A
H
F
H
E
WLAG
V
A
L
P
L
C
R
K
-
R
R
---
I
D
V
V
T
I
---------
F
T
T
H
A
-
T
L
L
G
R
Y
L
C
ASGSFDF
Y
N
C
---
L
E
-
S
V
D
-
V
----
D
H
E
A
--
G
R
F
G----
I
Y
----
H
R
Y
C
I
------
E
R
A
A
----
A
H
S
A
D
----
V
F
T
T
V
S
Q
I
T
A
----
F
E
A
-----
E
H
-
L
L
K
R
------
K
P
D
G
I
L
P
N
G
L
-------
N
V
I
K
F
QAFH
E
F
Q
N
L
H
A
-
L
K
K
E
K
I
N
D
F
V
R
G
H
-
F
------
H
G
C
F
D
F
D
L
D
N
T
L
Y
F
F
I
A
G
R
YEYKNK
G
------------------
A
D
M
F
I
E
A
L
A
R
L
N
Y
R
L
K
--
V
S
G
S
K
----
K
T
V
V
A
F
I
V
M
P
A
-----------
K
N
N
S
F
T
-
V
E
A
L
K
G
Q
A
-----------
E
-
V
R
A
L
E
N
T
V
H
E
V
T
T
S
--------
I
G
K
R
I
F
D
H
A
I
R
YPHNGLTTELPTD
L
G
E
L
L
K
S
S
D
K
V
--
M
---------------------------
L
K
R
R
---
I
-
L
A
L
R
R
P
E
G
Q
L
P
P
I
VTHNMVDDAND
L
I
L
N
------
K
I
R
Q
---
V
--
Q
L
F
N
S
P
S
-
D
R
V
K
M
I
F
HPEFLNAN
N
P
I
-
L
G
L
D
Y
D
E
F
V
R
G
CH
L
G
V
F
P
S
Y
Y
E
P
W
G
Y
T
P
A
E
C
T
V
M
G
V
P
S
I
T
-----
T
N
V
S
G
F
G
-------
S
Y
M
E
D
L
I
E
T
N
Q
--
A
K
D
Y
G
---
I
Y
I
V
D
RRFKA
P
D
E
S
V
E
Q
L
V
D
Y
M
-
E
--
E
F
V
K
---
K
T
R
R
--
Q
R
I
N
Q
R
N
A
T
E
--
A
L
S
D
L
L
DWK
R
M
------
G
L
E
Y
-----
V
K
A
R
Q
L
A
L
R
R
G
Y
P
D
Q
F
R
E
L
V
GEELNDSNMDALA---------------------------------------------------------------------------------------------------
18
HHSearch
27.33
27%
53
- C2 -
-
2KNC
-
ITA2B_HUMAN
A:
[991-1005]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
F
-----
K
R
N
R
P
P
L
E
E
D
D
E
------------------------------------------------------------------------------------------------------------------------
26
Fugue
25.88
29%
80
- C5 -
-
2AB3
-
?
A:
[1-29]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
V
Y
------
V
C
H
F
ENCGR
S
F
N
D
R
R
K
L
N
R
H
K
K
I
H
T
G
-------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
24.98
23%
-131
- C5 -
-
2WH8
1
CP130_MYCTU
A:
[215-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------
D
D
A
I
S
H
L
V
A
A
--------------------
G
V
G
A
-
D
G
---
D
T
A
G
T
L
---------
S
I
L
A
F
-
T
F
---------------
T
---
M
V
-
T
G
G
-
N
-----
D
T
V
--
T
G
M
-----
L
G
----
G
S
M
P
L
--------------------------------------
L
H
-----
R
R
-
P
D
Q
R
------
R
L
L
L
D
D
P
E
G
I
-------
P
-----------
D
A
V
E
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
24.86
9%
-217
- C5 -
-
1HGV
-
CAPSD_BPH75
A:
[12-43]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
N
Y
I
Q
A
I
A
A
A
G
V
G
V
L
A
L
A
I
--------------
G
L
S
A
A
W
K
Y
A
K
--------------------
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
24.18
23%
-116
- C5 -
-
2UVN
2
CP130_MYCTU
A:
[216-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------
D
D
A
I
S
H
L
V
A
A
--------------------
G
V
G
A
-
D
G
---
D
T
A
G
T
L
---------
S
I
L
A
F
-
T
F
---------------
T
---
M
V
-
T
G
G
-
N
-----
D
T
V
--
T
G
M
-----
L
G
----
G
S
M
P
L
--------------------------------------
L
H
-----
R
R
-
P
D
Q
R
------
R
L
L
L
D
D
P
E
G
I
-------
P
-----------
D
A
V
E
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
23.90
23%
-113
- C5 -
-
2WGY
2
CP130_MYCTU
A:
[215-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------
D
D
A
I
S
H
L
V
A
A
--------------------
G
V
G
A
-
D
G
---
D
T
A
G
T
L
---------
S
I
L
A
F
-
T
F
---------------
T
---
M
V
-
T
A
G
-
N
-----
D
T
V
--
T
G
M
-----
L
G
----
G
S
M
P
L
--------------------------------------
L
H
-----
R
R
-
P
D
Q
R
------
R
L
L
L
D
D
P
E
G
I
-------
P
-----------
D
A
V
E
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------