@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0441: (2017-12-22 )
MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEESDKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
Atome Classification :
(61 SA)
.........10........20.......-.30........40........50.-.-..-....60....-..----------------..70.--------------.......80.........-90-.-....----...100.......110.......120------.--------......----..-130--.---------------.-----......---.140---.......150.......160.......170-........180.......190.......200.......210....--...220.......230...-.-.-.-.240.....-------..250.......--260-.---.---.---......270.......280--.-..--...-..-290.......300.......310.......320.......330.......340---..--.---.--...350.......360.......370.......380.......390......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
K
L
T
V
K
D
VDLKG
K
K
V
L
V
R
V
D
FNVPLKD-
G
V
ITNDN
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
QGG-R-
A
I
-
L
F
S
H
L
G
R
V
K
E
-
E
S----------------DKAGK--------------SL
A
P
V
A
A
D
-
L
A
A
K
LGQDV-VF-P-GVTR----G
A
E
L
E
A
A
I
N
ALEDG
Q
V
L
L
V
ENTRY--------E--------DVDGKK----ES-K----N---------------D-----
P
E
L
G
K
Y
---
W
A
S
L---GD
G
I
F
V
NDAFGTAHRAHASNVGIS
A
N
V
E
K
--
A
V
A
G
F
L
LE
N
E
I
A
Y
I
Q
E
A
VETPER
P
F
V
A
I
LGGSKV
S
D
K
I
G
V
I
E
N
L
L
--
E
KAD
K
V
L
IGG
G
M
T
Y
T
F
Y
K
A-Q-G-I-EI
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
E
K--A---N---
G
---
K
---
L
I
L
PVDSKEANAFAGYTE---V-RD--TEG-
E
A
-VSE
G
F
L
G
L
DI
G
P
K
S
I
A
K
F
D
E
A
LTGA
K
T
V
V
WNGPMGVFENPDFQA
G
T
I
G
V
M
D
A
I
---
V
K--Q---P--GV
K
S
IIGGGDS
A
A
A
A
I
NLGRAD
K
F
S
W
I
STGGGA
S
M
E
LLEGKVLP
G
L
A
A
LTEK
1
PsiBlast_PDB
99.22
100%
-75
- C6 -
-
3ZLB
5
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
D
-
G
V
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
-
L
F
S
H
L
G
R
V
K
E
-
E
S
----------------
D
K
A
G
K
--------------
S
L
A
P
V
A
A
D
-
L
A
A
K
L
G
Q
D
V
-
V
F
-
P
-
G
V
T
R
----
G
A
E
L
E
A
A
I
N
A
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
--------
E
--------
D
V
D
G
K
K
----
E
S
-
K
----
N
---------------
D
-----
P
E
L
G
K
Y
---
W
A
S
L
---
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
V
E
K
--
A
V
A
G
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
L
--
E
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
-
Q
-
G
-
I
-
E
I
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
E
K
--
A
---
N
---
G
---
K
---
L
I
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
T
E
---
V
-
R
D
--
T
E
G
-
E
A
-
V
S
E
G
F
L
G
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
---
V
K
--
Q
---
P
--
G
V
K
S
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
58
HHSearch
83.77
99%
19
- C6 -
-
3ZLB
5
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
D
-
G
V
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
-
L
F
S
H
L
G
R
V
K
E
-
E
S
D---------------
K
A
-
G
K
--------------
S
L
A
P
V
A
A
D
-
L
A
A
K
L
G
Q
D
V
-
V
F
-
P
-
G
V
T
R
----
G
A
E
L
E
A
A
I
N
A
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
--------
E
------------
D
V
DGKK
E
S
-
K
----
N
---------------
D
-----
P
E
L
G
K
Y
---
W
A
S
L
---
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
V
E
K
--
A
V
A
G
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
L
--
E
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
-
Q
-
G
-
I
-
E
I
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
E
K
--
A
---
N
---
G
---
K
---
L
I
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
T
E
---
V
-
R
D
--
T
E
G
-
E
A
-
V
S
E
G
F
L
G
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
---
V
K
--
Q
---
P
--
G
V
K
S
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
62
HHSearch
79.26
57%
-46
- C6 -
-
1VPE
2
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
G
-
E
P
----------------
S
P
-
E
F
--------------
S
L
A
P
V
A
K
R
-
L
S
E
L
L
G
K
E
V
-
K
F
-
V
-
P
A
V
V
----
G
D
E
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
------------
P
G
----
E
T
-
K
----
N
---------------
D
-----
P
E
L
A
K
F
---
W
A
S
L
---
A
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
-
K
-
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
--
A
---
K
E
K
G
V
---
E
---
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
---
K
-
K
V
--
V
R
I
D
D
G
-
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
---
A
A
--
L
T
E
-
K
--
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
57
HHSearch
78.91
51%
-52
* C6 *
-
1PHP
1
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
G
-
K
V
----------------
V
E
-
E
L
--------------
R
L
D
A
V
A
K
R
-
L
G
E
L
L
E
R
P
V
-
A
K
-
T
-
N
E
A
V
----
G
D
E
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
------------
P
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
A
K
A
---
F
A
E
L
---
A
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
-
H
-
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
--
A
---
K
E
K
G
V
---
R
---
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
---
T
-
K
V
--
V
P
I
-
D
A
-
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
---
A
E
--
A
---
L
--
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
3
PsiBlast_PDB
78.63
56%
-47
- C6 -
-
1VPE
2
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
G
-
E
P
----------------
S
P
E
F
---------------
S
L
A
P
V
A
K
R
-
L
S
E
L
L
G
K
E
V
-
K
F
-
V
-
P
A
V
V
----
G
D
E
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--------
H
------------
P
G
----
E
T
-
K
----
N
---------------
D
-----
P
E
L
A
K
F
---
W
A
S
L
---
A
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
--
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
-
K
-
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
--
A
---
K
---
E
---
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
K
K
V
V
-
R
I
--
D
D
G
----
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
-
L
T
--
E
---
K
--
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
5
PsiBlast_PDB
78.04
48%
-50
- C6 -
-
1V6S
2
PGK_THET8
A:
[3-388]
----
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
-
P
D
----------------
P
K
--
Y
--------------
S
L
A
P
V
G
E
A
-
L
R
A
H
L
P
E
A
R
-
F
A
-
P
-
F
P
P
G
----
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
-
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
--
A
Y
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
--
A
---
E
---
A
L
G
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
---
T
-
R
V
--
F
P
A
-
R
A
-
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
--
L
---
E
--
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
---
21
PsiBlast_CBE
76.82
48%
-48
- C6 -
-
1V6S
2
PGK_THET8
B:
[3-388]
----
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
-
P
D
----------------
P
K
--
Y
--------------
S
L
A
P
V
G
E
A
-
L
R
A
H
L
P
E
A
R
-
F
A
-
P
-
F
P
P
G
----
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
-
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
--
A
Y
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
--
A
---
E
---
A
LGV
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
---
T
-
R
V
--
F
P
A
-
R
A
-
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
--
L
---
E
--
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
---
6
PsiBlast_PDB
76.10
48%
-47
- C6 -
-
2IE8
-
?
A:
[3-388]
----
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
-
P
D
----------------
P
R
--
Y
--------------
S
L
A
P
V
G
E
A
-
L
R
A
H
L
P
E
A
R
-
F
A
-
P
-
F
P
P
G
----
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--------
E
------------
P
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
S
A
R
---
Y
A
R
L
---
G
E
A
-
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
--
A
Y
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
-
G
-
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
--
A
---
E
---
A
L
G
V
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
---
T
-
R
V
--
F
P
A
-
R
A
-
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
---
A
A
--
L
---
E
--
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
---
50
PsiBlast_CBE
70.82
43%
-30
- C6 -
-
4NG4
1
PGK_COXBU
B:
[15-400]
---
L
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
-
G
K
----------------
F
E
K
E
F
--------------
S
L
A
P
V
A
R
L
-
L
S
K
K
L
N
-
K
V
P
L
I
-
N
-
D
W
L
K
----
G
V
-------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------------------
N
K
G
----
E
N
-
E
----
N
---------------
N
-----
T
E
L
A
K
R
---
M
A
E
L
---
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
A
E
K
N
---
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
V
--
K
N
I
-
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
K
--
S
---
T
--
A
Y
-
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
59
HHSearch
70.40
46%
10
- C6 -
-
3Q3V
2
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
E
-
I
S
-----------------
S
-
K
Y
--------------
S
L
E
P
V
A
K
R
-
L
A
R
L
L
D
K
E
I
-
V
M
-
A
-
K
D
V
I
----
G
E
D
A
K
T
K
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
------------
K
G
----
E
T
-
K
----
N
---------------
D
-----
E
N
L
A
K
E
---
L
A
S
M
---
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
--
G
---
K
N
L
G
V
---
K
---
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
---
M
-
K
F
--
V
P
A
-
Q
E
-
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
E
--
G
------
H
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
75
HHSearch
70.18
45%
-22
- C6 -
-
4NG4
1
PGK_COXBU
B:
[14-400]
--
F
L
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
-
G
K
F---------------
E
K
-
E
F
--------------
S
L
A
P
V
A
R
L
-
L
S
K
K
L
N
-
K
V
-
P
L
-
I
-
N
D
W
L
----
K
G
------
V
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------
N
------------
K
G
----
E
N
-
E
----
N
---------------
N
-----
T
E
L
A
K
R
---
M
A
E
L
---
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
---
A
E
K
N
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
V
--
K
N
I
-
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
K
--
S
------
T
A
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
60
HHSearch
69.97
46%
6
- C6 -
-
3Q3V
4
PGK_CAMJE
B:
[7-399]
--
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
E
-
I
S
-----------------
S
-
K
Y
--------------
S
L
E
P
V
A
K
R
-
L
A
R
L
L
D
K
E
I
-
V
M
-
A
-
K
D
V
I
----
G
E
D
A
K
T
K
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--------
E
------------
K
G
----
E
T
-
K
----
N
---------------
D
-----
E
N
L
A
K
E
---
L
A
S
M
---
V
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
-
Y
-
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
--
G
---
K
N
L
G
V
---
K
---
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
---
M
-
K
F
--
V
P
A
-
Q
E
-
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
---
S
E
--
G
------
H
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
-
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
71
HHSearch
69.89
44%
-17
- C6 -
-
1ZMR
-
PGK_ECOLI
A:
[2-384]
-
S
V
I
K
M
T
D
L
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
K
D
-
G
K
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
-
K
-
V
M
-
V
T
S
H
L
G
R
P
T
E
-
G
E
Y---------------
N
E
-
E
F
--------------
S
L
L
P
V
V
N
Y
-
L
K
D
K
L
S
N
P
V
-
R
L
-
V
-
K
D
Y
L
----
D
G
------
V
D
V
A
E
G
E
L
V
V
L
E
N
V
R
F
--------
N
------------
K
G
----
E
K
-
K
----
D
---------------
D
-----
E
T
L
S
K
K
---
Y
A
A
L
---
C
D
-
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
G
K
F
A
D
V
--
A
C
A
G
P
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
S
--
K
I
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
-
H
-
D
V
G
K
S
L
Y
E
A
-------
D
L
V
D
E
A
K
R
L
L
T
T
----------
C
---
N
---
I
P
V
P
S
D
V
R
V
A
T
E
F
S
E
T
A
P
---
A
-
T
L
--
K
S
V
-
N
D
-
V
K
A
D
E
Q
I
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
E
I
V
A
N
A
I
---
A
D
--
S
------
E
A
F
S
I
A
G
G
G
D
T
L
A
A
I
D
L
F
G
I
A
D
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
R
49
PsiBlast_CBE
69.71
43%
-29
- C6 -
-
4NG4
1
PGK_COXBU
C:
[15-400]
---
L
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
-
G
K
----------------
F
E
K
E
F
--------------
S
L
A
P
V
A
R
L
-
L
S
K
K
L
N
--
V
P
L
I
-
N
-
D
W
L
K
----
G
V
-------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------------------
N
K
G
----
E
N
-
E
----
N
---------------
N
-----
T
E
L
A
K
R
---
M
A
E
L
---
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
A
E
K
N
---
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
V
--
K
N
I
-
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
K
--
S
---
T
--
A
Y
-
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
52
PsiBlast_CBE
69.26
45%
-21
- C6 -
-
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
-
L
M
S
H
L
G
R
P
T
E
-
G
E
----------------
Y
D
S
Q
F
--------------
S
L
E
P
V
A
K
A
-
L
S
E
I
I
N
K
P
V
-
K
F
-
A
K
D
W
L
D
----
G
V
D
V
K
A
-------
G
E
I
V
M
C
E
N
V
R
F
--------
N
--------
S
--
G
E
K
----
K
S
-
T
----
D
---------------
D
-------
L
S
K
K
---
I
A
S
L
---
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
K
--
A
---
K
---
A
L
GV
N
---
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
---
A
-
I
I
--
K
K
V
-
S
D
-
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
---
A
---
Q
---
S
--
H
A
F
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
38
PsiBlast_CBE
68.94
46%
12
- C6 -
-
2XE6
1
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
74
HHSearch
68.74
45%
-21
- C6 -
-
4NG4
1
PGK_COXBU
A:
[14-400]
--
F
L
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
-
G
K
F---------------
E
K
-
E
F
--------------
S
L
A
P
V
A
R
L
-
L
S
K
K
------
P
L
-
I
-
N
D
W
L
----
K
G
------
V
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------
N
------------
K
G
----
E
N
-
E
----
N
---------------
N
-----
T
E
L
A
K
R
---
M
A
E
L
---
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
---
A
E
K
N
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
V
--
K
N
I
-
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
K
--
S
------
T
A
Y
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
48
PsiBlast_CBE
68.68
45%
7
- C6 -
-
1HDI
2
PGK1_PIG
A:
[2-411]
--
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
S
P
----------------
M
P
D
K
Y
--------------
S
L
Q
P
V
A
A
E
-
L
K
S
A
L
G
K
A
V
-
L
F
-
L
-
K
D
C
V
----
G
P
A
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
A
A
-
G
----
E
---------------
P
-----
A
K
I
K
A
F
---
R
A
S
L
S
A
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
S
K
A
A
A
---
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
A
K
---
I
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
51
PsiBlast_CBE
68.46
43%
-25
- C6 -
-
4NG4
1
PGK_COXBU
A:
[15-400]
---
L
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
-
G
K
----------------
F
E
K
E
F
--------------
S
L
A
P
V
A
R
L
-
L
S
K
K
-----P
L
I
-
N
-
D
W
L
K
----
G
V
-------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------------------
N
K
G
----
E
N
-
E
----
N
---------------
N
-----
T
E
L
A
K
R
---
M
A
E
L
---
C
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
A
E
K
N
---
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
V
--
K
N
I
-
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
---
A
K
--
S
---
T
--
A
Y
-
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
44
PsiBlast_CBE
68.38
46%
-1
- C6 -
-
2X14
2
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKG-------------------
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
42
PsiBlast_CBE
68.18
46%
13
- C6 -
-
4O33
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
56
PsiBlast_CBE
68.12
35%
-29
- C6 -
-
2CUN
4
PGK_PYRHO
A:
[2-398]
---
F
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
S
-
E
D
----------------
Y
T
T
T
E
--------------
E
H
A
R
V
L
S
E
-
L
---
L
D
Q
H
V
-
E
Y
-
I
-
E
D
I
F
----
G
R
Y
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
SA------
E
--------
E
V
K
N
K
P
I
---
E
E
-
C
----
E
---------------
K
-----
T
F
L
V
K
K
---
L
S
K
V
---
I
D
Y
V
-
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
--
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
E
--
F
---
Y
---
P
---
Y
---
I
R
T
P
V
D
F
--
A
V
D
Y
K
G
E
R
V
---
E
-
I
D
LL
S
E
N
-
R
G
-
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
D
--
S
---
P
--
A
F
-
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
-
I
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
---
47
PsiBlast_CBE
68.11
46%
9
- C6 -
-
4O3F
2
PGK1_MOUSE
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
A
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
N
A
C
A
N
P
A
A
G
T
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
D
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
55
PsiBlast_CBE
68.01
35%
-26
- C6 -
-
2CUN
4
PGK_PYRHO
B:
[2-398]
---
F
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
S
-
E
D
----------------
Y
T
T
T
E
--------------
E
H
A
R
V
L
S
E
-
L
---
L
D
Q
H
V
-
E
Y
-
I
-
E
D
I
F
----
G
R
Y
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
SA------
E
--------
E
V
K
N
K
P
I---
E
E
-
C
----
E
---------------
K
-----
T
F
L
V
K
K
---
L
S
K
V
---
I
D
Y
V
-
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
--
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
RR
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
-
F
-
D
L
G
R
K
N
V
E
F
MKKKGLL
D
Y
V
K
H
A
E
E
I
L
D
E
--
F
---
Y
---
P
---
Y
---
I
R
T
P
V
D
F
--
A
V
D
Y
K
G
E
R
V
---
E
-
I
D
LL
S
E
N
-
R
G
-
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
---
A
D
--
S
---
P
--
A
F
-
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
-
I
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
---
19
PsiBlast_PDB
67.76
46%
6
- C6 -
-
3C3C
2
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
37
PsiBlast_CBE
67.51
46%
13
- C6 -
-
2XE7
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
32
PsiBlast_CBE
67.42
46%
-2
- C6 -
-
2WZC
2
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKG-------------------
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
7
PsiBlast_PDB
67.35
48%
13
- C6 -
-
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
G
-
E
R
----------------
N
E
K
-
Y
--------------
S
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
-
T
F
-
L
-
N
D
C
V
----
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEG
S
R
-
K
V
D
G
Q
K
----
V
K
-
A
----
S
---------------
K
-----
E
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
--
A
---
K
---
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
---
T
-
K
T
V
-
T
D
K
-
E
G
-
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
K
--
S
---
S
A
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
20
PsiBlast_PDB
67.29
46%
-1
- C6 -
-
2WZB
3
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKG-------------------
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
36
PsiBlast_CBE
67.19
46%
14
- C6 -
-
2XE8
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
--------
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
41
PsiBlast_CBE
67.03
45%
18
- C6 -
-
2P9T
1
PGK2_MOUSE
A:
[4-414]
-
A
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
D
E
-
L
K
S
L
L
N
K
D
V
-
I
F
-
L
-
K
D
C
V
----
G
P
E
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
S
S
G
K
K
----
I
S
-
A
----
D
---------------
P
-----
A
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
--
A
E
K
-
N
---
G
V
--
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
---
V
-
G
Q
--
A
T
I
-
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
N
--
G
C
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
--
63
HHSearch
66.96
46%
-12
- C6 -
-
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
-
L
M
S
H
L
G
R
P
T
E
-
G
E
Y---------------
D
S
-
Q
F
--------------
S
L
E
P
V
A
K
A
-
L
S
E
I
I
N
K
P
V
-
K
F
-
A
-
K
D
W
L
----
D
G
------
V
D
V
K
A
G
E
I
V
M
C
E
N
V
R
F
--------
N
------------
S
G
----
E
K
-
K
----
S
---------------
T
-----
D
D
L
S
K
K
---
I
A
S
L
---
G
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
-
F
-
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
K
--
A
---
K
A
L
G
V
---
N
---
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
---
A
-
I
I
--
K
K
V
-
S
D
-
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
---
A
Q
--
S
------
H
A
F
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
69
HHSearch
66.88
50%
9
- C6 -
-
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
G
-
E
R
----------------
N
E
-
K
Y
--------------
S
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
-
T
F
-
L
-
N
D
C
V
----
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
------------
I
E
----
E
E
-
G
S
R
K
V
D
GQKVKAS
K
E
D
-----
V
-----
Q
K
F
R
H
E
---
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
-
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
--
A
---
K
A
K
G
V
---
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
---
T
-
K
T
--
V
T
D
K
E
G
-
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
K
--
S
---
S
A
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
11
PsiBlast_PDB
66.79
46%
10
- C6 -
-
1KF0
2
PGK1_PIG
A:
[5-414]
--
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
S
P
----------------
M
P
D
K
Y
--------------
S
L
Q
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
K
T
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
H
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
34
PsiBlast_CBE
66.71
46%
6
- C6 -
-
3ZOZ
3
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG---------------------------
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
25
PsiBlast_CBE
66.67
46%
14
- C6 -
-
2Y3I
2
PGK1_HUMAN
D:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKGK
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
SKL
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
EK-
N
---
G
V--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
AT
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
16
PsiBlast_PDB
66.66
46%
6
- C6 -
-
3C39
1
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKGK-----------
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
35
PsiBlast_CBE
66.61
46%
15
- C6 -
-
2YBE
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
-------------
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
43
PsiBlast_CBE
66.57
46%
-1
- C6 -
-
2WZD
3
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKG-------------------
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
13
PsiBlast_PDB
66.50
46%
11
- C6 -
-
1VJD
1
PGK1_PIG
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
S
K
----
V
K
-
A
----
D
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
31
PsiBlast_CBE
66.40
46%
13
- C6 -
-
2X13
2
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKGK-----------
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
15
PsiBlast_PDB
66.21
46%
15
- C6 -
-
2ZGV
1
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
30
PsiBlast_CBE
66.04
46%
10
- C6 -
-
2X15
2
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEGKGK-----------
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
40
PsiBlast_CBE
65.98
45%
22
- C6 -
-
2PAA
1
PGK2_MOUSE
A:
[4-414]
-
A
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
D
E
-
L
K
S
L
L
N
K
D
V
-
I
F
-
L
-
K
D
C
V
----
G
P
E
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
S
S
G
K
K
----
I
S
-
A
----
D
---------------
P
-----
A
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
--
A
E
K
-
N
---
G
V
--
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
---
V
-
G
Q
--
A
T
I
-
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
N
--
G
C
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
--
27
PsiBlast_CBE
65.96
46%
8
- C6 -
-
3C3B
1
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
--------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
28
PsiBlast_CBE
65.92
46%
5
- C6 -
-
3C3A
2
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
---------
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
14
PsiBlast_PDB
65.83
46%
14
- C6 -
-
2Y3I
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
29
PsiBlast_CBE
65.70
46%
10
- C6 -
-
3C39
1
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
----------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
33
PsiBlast_CBE
65.60
46%
11
- C6 -
-
4AXX
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
HVEEEGKG
K
---------------------
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
12
PsiBlast_PDB
65.50
46%
15
- C6 -
-
1VJC
1
PGK1_PIG
A:
[5-414]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
S
K
----
V
K
-
A
----
D
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
66
HHSearch
65.33
47%
23
- C6 -
-
1VJC
1
PGK1_PIG
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
-
L
M
S
H
L
G
R
P
D
G
-
I
P
M---------------
P
D
-
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
------------
V
E
----
E
E
-
G
----
K
G
K
D
ASG
S
K
V
K
A
D
P
A
K
I
-----
E
A
F
R
A
S
---
L
S
K
L
---
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
--
A
---
E
K
N
G
V
---
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
-
G
Q
--
A
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
---
V
K
--
A
T
S
-
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
26
PsiBlast_CBE
65.32
46%
6
- C6 -
-
3C3C
1
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
--------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
17
PsiBlast_PDB
65.21
46%
11
- C6 -
-
3C3A
1
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
V
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
VEEEG
K
G
K
D
A
S
G
N
K
----
V
K
-
A
----
E
---------------
P
-----
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
---
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
A
--
T
V
A
-
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
A
T
S
---
R
--
G
C
I
T
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
--
70
HHSearch
65.16
47%
13
- C6 -
-
16PK
2
PGKC_TRYBB
A:
[2-415]
--
K
K
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
-
E
G
G
S
-
C
V
-
L
M
S
H
L
G
R
P
K
G
-
I
P
MAQ
A
G
K
I
R
S
T
GGVPGF
Q
Q
-
K
A
--------------
T
L
K
P
V
A
K
R
-
L
S
E
L
L
L
R
P
V
-
T
F
-
A
-
P
D
C
L
----
N
--
A
A
D
V
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
--------
Y
------------
K
E
----
E
G
S
K
----
K
A
K
D
------------
R
-----
E
A
M
A
K
I
---
L
A
S
Y
---
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
G
N
--
G
A
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
--
A
---
E
D
R
K
V
---
Q
---
V
I
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
---
P
-
L
I
--
T
E
D
-
Q
N
-
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
---
G
R
--
G
T
H
E
H
--
G
L
M
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
9
PsiBlast_PDB
65.01
44%
14
- C6 -
-
16PK
2
PGKC_TRYBB
A:
[2-415]
--
K
K
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
-
L
M
S
H
L
G
R
P
K
G
I
P
M
----------------
A
Q
A
G
K
I
R
S
T
GGVPGFQQKA
T
L
K
P
V
A
K
R
-
L
S
E
L
L
L
R
P
V
-
T
F
A
P
-
D
C
L
N
----
A
A
D
V
---
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
--------
Y
--------
K
E
E
G
S
K
----
K
A
-
K
----
D
---------------
R
-----
E
A
M
A
K
I
---
L
A
S
Y
---
G
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
G
N
--
G
A
A
G
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
-
Y
-
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
--
A
---
E
---
D
---
R
K
V
Q
V
I
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
---
P
-
L
I
--
T
E
D
-
Q
N
-
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
G
R
G
T
H
--
E
---
H
--
G
L
M
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
67
HHSearch
64.90
47%
23
- C6 -
-
2WZB
3
PGK1_HUMAN
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
-
L
M
S
H
L
G
R
P
D
G
-
V
P
M---------------
P
D
-
K
Y
--------------
S
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
-
L
F
-
L
-
K
D
C
V
----
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--------
H
------------
V
E
----
E
E
-
G
KG-------------------E
P
A
K
I
E
A
F
R
A
S
---
L
S
K
L
---
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
-
M
-
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
---
E
K
N
G
V
---
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
-
G
Q
--
A
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
---
V
K
--
A
T
S
-
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
4
PsiBlast_PDB
63.38
49%
28
- C6 -
-
1PHP
1
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
-----------------------
G
K
--------------
V
V
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
-
E
R
-
P
-
V
A
K
T
NEAV
G
D
E
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--------
Y
------------
P
G
----
E
E
-
K
----
N
---------------
D
-----
P
E
L
A
K
A
---
F
A
E
L
---
A
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
-
A
H
Y
L
P
--
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
-
H
-
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
--
A
---
K
---
E
---
K
G
V
R
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
---
T
-
K
V
--
V
P
I
-
D
A
-
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
---
A
E
--
A
---
L
--
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
39
PsiBlast_CBE
63.21
45%
18
- C6 -
-
2PAA
1
PGK2_MOUSE
B:
[4-414]
-
A
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
-
I
P
----------------
M
P
D
K
Y
--------------
S
L
E
P
V
A
D
E
-
L
K
S
L
L
N
K
D
V
-
I
F
-
L
-
K
D
C
V
----
G
P
E
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--------
H
VEEEGKGK
D
S
S
G
K
K
----
I
S
-
A
----
D
---------------
P
-----
A
K
V
E
A
F
---
R
A
S
L
SKL
G
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
-
M
-
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
--
A
EK-
N
---
G
V--
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
---
V
-
G
Q
--
A
T
I
-
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
---
V
K
AT
S
---
N
--
G
C
V
T
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
--
68
HHSearch
61.88
49%
-9
- C6 -
-
3PGK
2
PGK_YEAST
A:
[5-415]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
R
P
N
G
-
E
R
----------------
N
E
-
K
Y
--------------
S
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
-
T
F
-
L
-
N
D
C
V
----
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
------------
I
E
----
E
E
-
G
SRKV
D
G
Q
K
V
K
A
SK
E
D
-----
V
-----
Q
K
F
R
H
E
---
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
-
E
N
T
-
E
I
G
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
E
K
--
A
---
K
A
K
G
V
---
E
---
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
S
A
N
---
T
-
K
T
--
V
T
D
K
E
G
-
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
---
V
K
--
S
---
S
AA
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
10
PsiBlast_PDB
60.38
47%
-7
- C6 -
-
3PGK
2
PGK_YEAST
A:
[5-415]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
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N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
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I
K
Y
V
L
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H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
R
P
N
G
-
E
R
----------------
N
E
K
-
Y
--------------
S
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
-
T
F
-
L
-
N
D
C
V
----
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEGSR-
K
V
D
G
Q
K
----
V
K
-
A
----
S
---------------
K
-----
E
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
P
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--
R
A
A
G
F
L
L
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K
E
L
K
Y
F
G
K
A
L
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N
P
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P
F
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L
G
G
A
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A
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K
I
Q
L
I
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N
L
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--
D
K
V
D
S
I
I
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G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
-
T
-
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I
G
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
E
K
--
A
---
K
---
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
S
A
N
---
T
-
K
T
V
-
T
D
K
-
E
G
-
I
P
A
G
W
Q
G
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L
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A
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A
K
A
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W
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P
P
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V
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F
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F
A
A
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T
K
A
L
L
D
E
V
---
V
K
--
S
---
S
AA
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
53
PsiBlast_CBE
54.55
47%
22
- C6 -
-
1FW8
4
PGK_YEAST
A:
[4-343]
-----------------------------------------------------------------------------------------------------------
S
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
-
T
F
-
L
-
N
D
C
V
----
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--------
H
IEEEG
S
R
-
K
V
D
G
Q
K
----
V
K
-
A
----
S
---------------
K
-----
E
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
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K
Y
F
G
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A
L
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N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
-
T
-
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
--
A
---
K
---
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
---
T
-
K
T
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-
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D
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-
E
G
-
I
P
A
G
W
Q
G
L
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N
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L
F
A
A
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A
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A
K
T
I
V
W
N
G
P
P
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F
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F
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F
A
A
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A
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---
V
K
--
S
---
S
A
A
G
N
T
V
I
I
G
G
G
D
T
A
T
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A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K