@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0455: (2017-12-22 )
MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKEEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKENGIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFDDLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNEVDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQGLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK
Atome Classification :
(99 SA)
...--......10........20........30........40.-.-.-.....50........60-.-.......70.-------------------...-------------------------.------------------------..---------------------------.---------------------------80------------........90........100.......110.......120.......130.......140.......150...--.-.-.---.160..-......170.......180---..----......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..-.-..-.-.-330.......340.......350..-----.-----....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470...-.-...480.......490-.........500.......510.......520.--.---....-.530.......540-.........---550.......560.......570.......580.......590.......600.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
K
--
I
I
G
I
D
LGTTN
S
A
V
A
V
L
EGTE
S
K
I
I
ANPEGNRTT
P
S
V
V
S
F-K-N-G
E
I
I
VGDAAKRQAVTNP-D-
T
V
I
S
I
KSKMG-------------------TSE-------------------------K------------------------VS---------------------------A---------------------------NG------------KEY
T
P
Q
E
I
S
A
M
I
L
Q
Y
L
K
G
Y
A
E
D
Y
L
G
E
K
V
T
K
A
V
I
T
VPAYF
N
D
A
Q
R
Q
A
T
KDAGKIAGL
E
V
E
R
I
VNEP
T
A
A
A
L
A
YGL--D-K-T---DK-E
E
K
-
I
L
V
F
DLGG
G
T
F
D
V
S
I
L
EL----G
D
----
G
V
F
D
V
L
S
TAGDNKLGG
D
D
F
D
Q
K
I
I
D
H
L
V
A
E
F
K
KENGIDL
S
T
D
K
M
A
M
Q
R
L
K
D
A
A
E
K
A
K
K
D
LSGVTST
Q
I
S
L
P
F
I
TAGEAG
P
L
H
L
E
M
T
L
T
R
A
K
F
D
D
L
T
R
D
L
V
E
RTK
V
P
V
R
Q
A
L
S
D
AGL
S
L
S
E
ID
E
V
I
L
VGGSTR
I
P
A
V
V
E
A
V
K
-
A
-ET-G-K-EPNKSV
N
P
D
E
V
V
A
MGAAIQG
G
V
I
TG-----D-----V
K
D
V
V
L
L
DVT
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
IDRNTTIPTSK
S
Q
V
F
STAADNQP
A
V
D
I
H
V
LQGERPMAADNKTLG
R
F
Q
LTDIPAAPRGI
P
Q
I
E
V
T
F
DIDKN
G
I
V
S
V
K
AKDLGTQK
E
Q
T
I
V
I
QSNS-G-L
T
D
E
E
I
D
R
M
M
K
D
AE---ANAEA
D
K
K
R
K
E
E
V
D
L
R
N
E
V
D
Q
A
I
F
A
T
E
K
T
I
K
ET--E---GKGF-DA
E
R
D
A
A
Q
A
A
L
D
---
D
L
K
K
A
QEDN---
N
L
D
D
M
K
A
K
L
E
A
L
N
E
KAQ
G
L
A
V
K
L
Y
E
Q
A
A
A
A
Q
Q
A
Q
EGAEGAQATGNAGDDVVDGEFTEK
116
HHSearch
88.01
81%
-67
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
-------------------
T
D
Y
-------------------------
K
------------------------
V
E
---------------------------
I
---------------------------
E
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
E
----
E
-
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
---
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.74
80%
-66
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
-------------------
T
D
Y
-------------------------
K
------------------------
V
E
---------------------------
I
---------------------------
E
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-----
E
E
-
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
---
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
------------------------------------------------------------------------------------------------------------------
107
HHSearch
79.70
58%
55
- C2 -
-
4B9Q
1
DNAK_ECOLI
A:
[2-602]
-
G
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
-
Q
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
-
Q
N
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
------------------------
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
----
D
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
------
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
-----------------------------------
111
HHSearch
79.28
51%
53
- C2 -
-
5E84
1
GRP78_HUMAN
B:
[5-606]
-
G
T
--
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
-
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
-
E
N
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
-------------------------
N
------------------------
D
P
SVQQDIKFLPFKVVEKKTKPYIQVD--
I
GGG------------------------
Q
T
------------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
-
F
F
-
N
G
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-----
D
QD---
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
----
G
G
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
-
L
T
P
E
E
I
E
R
M
V
N
D
A
E
---
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
K
EK
L
---
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
---
E
K
I
E
W
L
E
S
H
QDA
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
------------------------------------
108
HHSearch
79.15
57%
53
- C2 -
-
4JNE
4
DNAK_ECOLI
A:
[1-600]
S
G
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
-
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
-
Q
N
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
------------------------
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
----
D
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
------
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
---------------------------------
22
PsiBlast_CBE
78.99
55%
52
- C2 -
-
4JN4
4
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
E
---------------------------
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
--
G
---
D
K
L
P
-
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------
117
HHSearch
78.80
81%
-
- C2 -
-
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
-------------------
T
D
Y
-------------------------
K
------------------------
V
E
---------------------------
I
---------------------------
E
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
E
----
E
-
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
---
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
-------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.63
55%
51
- C2 -
-
4JNE
4
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---------------------------
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
--
G
---
D
K
L
P
-
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------
21
PsiBlast_CBE
78.56
55%
52
- C2 -
-
4JNE
4
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
E
---------------------------
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
--
G
---
D
K
L
P
-
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------
4
PsiBlast_PDB
78.53
55%
50
- C2 -
-
4JN4
4
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---------------------------
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
--
G
---
D
K
L
P
-
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------
2
PsiBlast_PDB
78.37
80%
-
- C2 -
-
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
-
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
-------------------
T
D
Y
-------------------------
K
------------------------
V
E
---------------------------
I
---------------------------
E
G
------------
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-----
E
E
-
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
L
-
G
-
K
-
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
-----
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
---
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
-------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.96
55%
54
- C2 -
-
4B9Q
1
DNAK_ECOLI
A:
[3-598]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---------------------------
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
--
G
---
D
K
L
P
-
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------
27
PsiBlast_CBE
77.64
48%
52
- C2 -
-
5E84
1
GRP78_HUMAN
B:
[7-606]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
-
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
DQ---
D
-----
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
----
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
-
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
---
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
K
--
E
KLG
G
K
L
S
-
S
E
D
K
E
T
M
E
K
A
V
E
EKI
E
W
L
E
S
H
Q
D
A
---
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
------------------------------------
7
PsiBlast_PDB
76.87
48%
51
- C2 -
-
5E84
1
GRP78_HUMAN
A:
[7-606]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
-
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
DQ---
D
-----
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
----
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
-
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
---
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
K
--
E
KLG
G
K
L
S
-
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
L
E
S
H
Q
D
A
---
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
------------------------------------
26
PsiBlast_CBE
76.49
48%
51
- C2 -
-
5E84
1
GRP78_HUMAN
C:
[7-606]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
-
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
DQ---
D
-----
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
----
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
-
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
---
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
K
--
E
KLG
G
K
L
S
-
S
E
D
K
E
T
M
E
K
A
V
E
EKI
E
W
L
E
S
H
Q
D
A
---
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
------------------------------------
3
PsiBlast_PDB
75.77
56%
51
- C3 -
-
2KHO
-
DNAK_ECOLI
A:
[4-598]
-----
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
-
D
-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
-------------------
R
R
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
IMP
F
K
I
I
A
A
DNG
D
A
W
V
E
---------------------------
V
---------------------------
K
G
------------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
-
K
-
G
---
T
G
-
N
R
T
-
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
F
-
G
-
K
-
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
-----
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
---
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
--
G
---
D
K
L
P
-
A
D
D
K
T
A
I
E
S
A
L
T
---
A
L
E
T
A
L
K
G
E
---
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------
109
HHSearch
75.65
44%
38
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[14-619]
-
D
G
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
-
T
-
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
-
A
N
T
I
F
D
V
K
R
L
I
G
-------------------
R
R
F
-------------------------
D
------------------------
D
P
T
V
K
K
D
M
E
S
WP
F
K
V
V
D
D
NG
N
P
K
------
V
E
V
QYLG---------------------
Q
T
------------
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
G
-
S
-
G
KS-
D
K
-
E
R
N
-
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
G
----
E
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
-
E
-
F
F
-
D
-
G
K
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
-----
K
ATSAD--
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
D
N
Q
Q
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
G
K
-
L
S
T
D
E
I
E
K
M
I
S
D
A
E
---
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
S
D
---------------
K
D
K
I
E
Q
A
L
S
---
E
A
M
A
Q
L
E
I
E
DS-
T
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
T
K
A
M
A
-------------------------------------
114
HHSearch
75.08
52%
41
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[4-553]
-
G
P
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
-
T
N
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
-------------------------
D
------------------------
D
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
--
Y
KG-------------------------
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
K
V--
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
-
D
-
F
F
-
N
G
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
-
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
---
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
---------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.65
49%
45
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[4-553]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
-
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
---
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
---------------------------------------------------------------------------------------------------
115
HHSearch
73.24
52%
41
- C2 -
-
1YUW
-
HSP7C_BOVIN
A:
[4-554]
-
G
P
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
-
T
N
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
-------------------------
D
------------------------
D
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
--
Y
KG-------------------------
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
K
V--
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
-
D
-
F
F
-
N
G
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSEN-
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
-
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
---
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
E
--------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.93
49%
48
- C2 -
-
3C7N
2
HSP7C_BOVIN
B:
[3-547]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K------
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
-
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
---
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
---------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.53
46%
39
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[17-560]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
-
T
-
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
-
T
I
F
D
V
K
R
L
I
G
RRFDD
P
-------------
T
V
K
-------------------------
K
D
M
E
S
WP
F
K
V
---------------
V
D
---------------------------
D
---------------------------
N
G
N
P
K
V
E
V
QYLG
Q
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
GS
G
-
K
-
S
---
D
K
-
E
R
N
-
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
G
E
----
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
-
E
-
F
F
D
G
-
K
-
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
KATSA
D
-------
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
D
N
Q
Q
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
-
G
K
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
----------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.34
46%
34
- C2 -
-
5TKY
2
SSB1_CHATD
B:
[17-559]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
-
T
-
E
-
N
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
-
T
I
F
D
V
K
R
L
I
G
RRFDD
P
-------------
T
V
K
-------------------------
K
D
M
E
S
WP
F
K
V
---------------
V
D
---------------------------
D
---------------------------
N
G
N
P
K
V
E
V
Q
Y
LG
Q
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
-
K
-
S
---
D
K
-
E
R
N
-
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
G
E
----
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
-
E
-
F
F
D
G
-
K
-
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
K----
D
-----
T
S
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
----
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
-
G
K
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
----------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.04
50%
35
- C2 -
-
5EVZ
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.90
50%
34
- C2 -
-
5F0X
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
62.86
50%
34
- C2 -
-
3LDP
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
62.78
52%
27
* C2 *
-
4J8F
1
F10A1_RAT (first)
A:
[11-389]
-
A
A
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
-
Q
N
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
-------------------------
G
------------------------
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
------------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
G--
K
G
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
-
D
-
F
F
-
N
-
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
62.69
50%
36
- C2 -
-
5F1X
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
--
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.64
50%
38
- C2 -
-
3IUC
1
GRP78_HUMAN
A:
[28-404]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
62.57
50%
33
- C2 -
-
3LDL
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.53
50%
35
- C2 -
-
5EX5
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
62.44
51%
18
- C2 -
-
1QQN
1
HSP7C_BOVIN
A:
[1-377]
-
G
P
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
-
T
N
T
V
F
D
A
K
R
L
I
G
-------------------
R
A
F
-------------------------
D
------------------------
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
A
P
K
V
Q
V
E
Y
KG
E
T
------------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
A
V--
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
A
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
-
D
-
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
62.42
50%
38
- C2 -
-
5F2R
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
62.33
48%
41
- C2 -
-
1ATR
1
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
-
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
62.31
50%
35
- C2 -
-
5EVZ
1
GRP78_HUMAN
B:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
-
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.21
50%
37
- C2 -
-
5EXW
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
62.08
50%
35
- C2 -
-
5F1X
1
GRP78_HUMAN
B:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
62.01
50%
37
- C2 -
-
5EX5
1
GRP78_HUMAN
B:
[23-399]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
-
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
61.94
48%
23
- C2 -
-
4H5R
2
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
61.75
48%
25
- C2 -
-
4H5N
2
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
61.69
50%
37
- C2 -
-
5F2R
1
GRP78_HUMAN
B:
[23-399]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
-
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
61.56
50%
36
- C2 -
-
5EXW
1
GRP78_HUMAN
B:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
--
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.52
48%
39
- C2 -
-
1NGF
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
-
V
---
G
A
-
E
R
N
-
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
61.34
48%
23
- C2 -
-
4H5V
4
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
61.32
48%
28
- C2 -
-
4H5T
1
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
61.27
49%
28
- C2 -
-
3ATV
1
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.23
49%
24
- C2 -
-
3FE1
2
HSP76_HUMAN
B:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
RKFAD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
-------------------
R
------------------------
V
C
---------------------------
Y
---------------------------
R
G
E
D
----------
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
R
---
G
A
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
61.23
48%
37
- C2 -
-
2QWL
2
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
ET----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
61.20
50%
39
- C2 -
-
5F0X
2
GRP78_HUMAN
B:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
-Q
T
----------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
61.19
50%
34
- C2 -
-
3LDL
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
61.13
50%
35
- C2 -
-
3IUC
1
GRP78_HUMAN
C:
[28-406]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
------
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
61.11
48%
37
- C2 -
-
2QWM
2
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
ET----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
61.02
47%
32
- C2 -
-
2QWN
1
HSP7C_BOVIN
A:
[3-385]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
60.94
50%
37
- C2 -
-
3LDO
1
GRP78_HUMAN
A:
[7-384]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
G
Q
T
---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
60.92
48%
35
- C2 -
-
1NGG
1
HSP7C_BOVIN
A:
[3-381]
--
K
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
60.92
48%
35
- C2 -
-
1NGJ
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
60.84
49%
29
- C2 -
-
1HJO
1
HS71A_HUMAN
A:
[5-380]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
60.81
48%
37
- C2 -
-
3HSC
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
60.81
48%
39
- C2 -
-
2QWM
2
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.78
51%
43
- C2 -
-
3QFU
1
GRP78_YEAST
A:
[20-394]
-----
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
-
D
-
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
-
T
I
F
D
I
K
R
L
I
G
-------------------
L
K
Y
ND
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
------------------------
V
S
---------------------------
V
---------------------------
K
G
E
K
----------
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
S
---
D
K
-
E
H
Q
-
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
----
G
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
-
S
-
Y
F
D
G
-
K
-
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.77
48%
27
- C2 -
-
4H5W
1
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.61
47%
32
- C2 -
-
2QWQ
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
60.58
47%
31
- C2 -
-
2QWR
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.55
49%
31
- C2 -
-
3A8Y
1
HS71A_HUMAN
A:
[11-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
MKHWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
60.48
49%
26
- C2 -
-
4J8F
1
F10A1_RAT (first)
A:
[14-389]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
G
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
60.48
49%
25
- C2 -
-
3FE1
1
HSP76_HUMAN
C:
[24-402]
-
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
RKFAD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
-------------------
R
------------------------
V
C
---------------------------
Y
---------------------------
R
G
E
D
----------
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
R
---
G
A
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.47
48%
37
- C2 -
-
1BUP
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.44
50%
40
- C2 -
-
2V7Z
1
HSP7C_RAT
A:
[2-382]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
KHWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
A
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
K
---
V
R
-
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
T
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
60.41
48%
35
- C2 -
-
1NGB
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
60.41
50%
35
- C2 -
-
3LDO
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.39
47%
37
- C2 -
-
2QWP
4
HSP7C_BOVIN
A:
[4-389]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSEN-
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
60.38
49%
49
- C2 -
-
5BPN
1
HS71A_HUMAN
A:
[7-381]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
-
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
DK
P
K
V
--
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
---
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
Q
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
60.38
48%
26
- C2 -
-
4H5W
1
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
ET----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
60.30
49%
32
- C2 -
-
4IO8
1
HS71A_HUMAN
A:
[7-379]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
D
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
60.30
47%
38
- C2 -
-
2QWO
4
HSP7C_BOVIN
A:
[4-390]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
KSEN-
V
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.30
50%
26
- C2 -
-
5BPL
2
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.23
48%
36
- C2 -
-
1NGD
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
-
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
60.23
48%
36
- C2 -
-
1NGI
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
60.20
48%
37
- C2 -
-
1HPM
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
60.15
48%
39
- C2 -
-
1BA1
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
60.09
51%
43
- C2 -
-
3I33
2
HSP72_HUMAN
A:
[23-402]
-
M
P
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
-
T
N
T
I
F
D
A
K
R
L
I
G
-------------------
R
K
F
-------------------------
E
------------------------
D
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
K
G
---------------------------
E
T
------------
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
K
GCA
G
G
-
E
K
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
-
D
-
F
F
-
N
-
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
60.02
50%
32
- C2 -
-
3LDP
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
D
---------------------------
I
---------------------------
G
G
GQT---------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.87
49%
28
- C2 -
-
3AY9
1
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
59.83
49%
23
- C2 -
-
3FE1
1
HSP76_HUMAN
A:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
RKFAD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
-------------------
R
------------------------
V
C
---------------------------
Y
---------------------------
R
G
E
D
----------
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
R
---
G
A
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
-----
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.81
49%
22
- C2 -
-
3A8Y
1
HS71A_HUMAN
B:
[11-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
HWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
---
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.80
49%
26
- C2 -
-
3ATU
2
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
59.75
50%
39
- C2 -
-
5EY4
1
GRP78_HUMAN
B:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
D
---------------------------
I
---------------------------
G
-Q
T
----------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
59.74
48%
40
- C2 -
-
2QWL
2
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
-----
D
K---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.73
49%
28
- C2 -
-
3JXU
1
HS71A_HUMAN
A:
[29-403]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
G
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
59.59
48%
36
- C2 -
-
1NGH
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.57
50%
55
- C2 -
-
5EY4
1
GRP78_HUMAN
A:
[23-400]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P
E
-
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
T
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
D
---------------------------
I
-----------------------------T-----------
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
R
---
E
G
-
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
-
F
N
-
G
-
K
-
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.54
50%
48
- C2 -
-
2V7Z
1
HSP7C_RAT
B:
[2-382]
-
S
K
GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
ET----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
A
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
-
K
---
V
R
-
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
T
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.50
50%
27
- C2 -
-
5BN9
2
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.45
48%
34
- C2 -
-
1NGA
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
--
D
-
K
K
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
59.44
48%
37
- C2 -
-
1BA0
1
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
-
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
59.37
48%
37
- C2 -
-
1NGC
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
-
V
---
G
A
-
E
R
N
-
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
59.30
48%
37
- C2 -
-
1NGE
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
R
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
E
---------------------------
Y
---------------------------
K
G
E
T
----------
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
K
-
V
---
G
A
-
E
R
N
-
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
N
-
G
-
K
-
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.08
49%
32
- C2 -
-
5BPM
1
HS71A_HUMAN
A:
[7-381]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
Q
R
A
K
K
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.60
49%
27
- C2 -
-
2E8A
1
HS71A_HUMAN
A:
[10-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
-
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
-------------------
R
K
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
S
---------------------------
Y
---------------------------
K
G
E
T
----------
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
-
R
-
T
---
G
K
-
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
N
-
G
-
R
-
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
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