@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0481: (2017-12-23 )
MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAAKIAASFKPAAAPKVEAKPAAPKVSAEKKTEKSEPAKPAVAKEEAKPAEPVAPKTEKVAAKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNRRFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEERFKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKKQARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTPKPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGETIELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTAWGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGDHFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADVQGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQARQQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIGGFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDIKMDDVIEAYVMEEIKR
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..-.....390.......400.......410.......420--.......430.......440.......450.......460.......470..--------..------------------..------------------.------------------480..----------.....490.......500.......510.......520.......530.......540...-..--------------------------.-.--------------------------550------------------------.-------------------------..-----------......560..------.------..------.------.570.------......580.......590-.....--.---..600.......610.......620.......630.......640..----.----..----..650-----...---------.--------.-------------..660.--.----..--.....670.......680.......690.......700.......710------------...---------.--..--------------..720-......--.730.......740.......750...-....760.......770.......780-----.------.------......790.......800.......810.......820.......830.---..-----....840-----...----.--....850--........860.......870.......880.......890.......900.......910----........920.......930--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
K
K
R
L
Y
E
I
A
K
E
LG
K
E
S
K
E
V
V
A
R
A
K
E
LGLDVKSHS
S
S
V
E
E
A
V
A
A
K
I
A
ASFKPAAAPKVEAKPAAPKVSAEKKTEKSEPAKPAVAKEEAKPAEPVAPK
T
E
K
VAAKPQSRN
F
K
A
E
R
E
A
R
A
K
E
Q
A
E
R
R
KQNKGNNR
D
Q
QQNGNRQKNDGRNGGKQGQSNRDNRRF
N
D
Q
A
K
K
Q
Q
G
Q
Q
K
R
R
N
E
R
R
Q
Q
E
DKRSNQAAPRID
F
K
A
R
A
A
A
LKAEQ
N
A
E
Y
A
R
S
S
E
E
R
F
K
Q
Y
Q
A
A
K
E
A
L
A
Q
ANKRK
E
P
E
E
I
F
E
E
A
A
K
L
A
E
Q
A
Q
Q
V
Q
A
V
V
E
VVPEKKEPAV
D
T
R
R
K
KQARPDKNRDDYDHEEDGP
R
K
Q
Q
KNRS
S
Q
N
Q
V
RNQKNSNWNNNKKNKKGNNKNNRNQTPKP
V
T
E
R
K
F
H
ELPT
E
F
EYTDGM
T
V
A
E
I
A
K
R
I
KR
E
P
A
E
I
V
K
K
L
F
M
M
G
VMATQ-NQSLDG
E
T
I
E
L
L
M
VDYGIEA
K
Q
K
VEVDN
A
D
I
E
R
F
F
VED--GYL
N
E
D
E
L
VERP
P
V
V
T
I
M
GHVDHG
K
T
T
L
L
D
T
L
RNSRVATGEAGGITQHIG
A
Y
--------
Q
I
------------------VE------------------N------------------G
K
K
I
T
----------
F
L
DTPG
H
A
A
F
T
S
M
RARGAS
V
T
D
I
T
I
L
V
V
AADDGVM
P
Q
T
I
E
A
INHSKAANV
P
I
I
V
A
I
NKIDK-PG--------------------------A-
N
--------------------------
P
--------------------------
E
-------------------------
R
V
-----------
I
G
E
L
A
EHGVMS------T------AW------G------GDS
E
F
------
V
E
I
S
A
K
F
N
Q
N
I
E
E
L
L
E
T
V
--
L
L
V
A
E
--
I
---
Q
E
LKADP
T
V
R
A
I
G
T
V
I
E
A
R
LDKGK
G
A
V
A
T
L
L
V
QQGTLNVQD
P
I
V
VGN----T----FG----
R
V
R
A
M
-----
T
N
D---------L--------G-------------
R
R
V
--
K
--V----AG--PST
P
V
S
I
TGLNEAPMAGD
H
F
A
V
Y
EDE
K
S
A
R
AA
G
E
E
R
A
K
R
A
L
M
K
Q
R
Q
A
-------------
T
QR---------
V
--
S
L
--------------
E
N
L
F
D
-
T
L
KAGE--
L
K
S
V
N
V
I
I
K
ADVQG
S
V
E
A
L
S
A
S
L
Q
KID-VE
G
V
K
V
T
I
V
H
S
A
VGAINESD
V
T
L
AEA------S------N------
A
F
I
V
GFNVRPT
P
Q
A
RQQAEAD
D
V
E
I
R
L
H
S
I
I
Y
K
V
I
E
E
M
E
E
A
M
K
G
MLD
P
E
F
---
E
E
-----
K
V
I
G
E
A
------
V
I
R
----
E
--
T
FKVSK---VGTIG
G
F
M
V
I
N
G
K
VARDS
K
V
R
V
I
RD
G
V
V
I
YDG
E
L
A
S
L
K
H
Y
K
D
D
V
K
E
V
TNGREG
G
L
M
I
DG-Y----NDI
K
M
D
D
V
I
E
A
Y
V
M
E
E
IKR----------------------------
4
PsiBlast_PDB
76.50
44%
-53
- C2 -
-
3J4J
-
IF2_THET8
A:
[69-569]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
-------------
K
A
R
---------
A
--
P
A
--------------
T
M
A
A
L
-
L
A
A
M
A
E
EG
A
K
E
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
A
T
-
T
E
D
V
K
I
N
I
L
A
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
A
R
E
P
Q
Y
---
K
E
-----
E
V
L
G
Q
A
------
E
V
R
----
A
--
I
F
R
L
P
T
---
G
K
Q
V
A
G
C
M
V
T
Q
G
R
I
P
R
N
A
E
V
R
V
L
R
D
G
Q
V
I
W
Q
G
R
I
A
S
L
K
R
F
K
E
D
V
R
E
V
A
Q
G
Y
E
C
G
I
G
L
D
G
-
F
----
D
D
F
R
E
G
D
V
I
E
A
F
Q
M
V
E
V
------------------------------
1
PsiBlast_PDB
75.27
51%
11
- C2 -
-
5ME0
-
IF2_ECOLI
W:
[382-882]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DT
G
A
A
A
E
----
P
R
A
P
V
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
D
Y
I
R
S
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
Y
--------
H
V
E-----------------
T
E
------------------
N
------------------
G
-
M
I
T
----------
F
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
V
V
V
A
V
N
K
I
D
K
-
P
E
--------------------------
A
-
D
--------------------------
P
--------------------------
D
-------------------------
R
V
-----------
K
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
W
------
G
------
G
E
S
Q
F
------
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
--
L
L
Q
A
E
--
V
---
L
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
I
V
L
C
G
F
----
E
----
Y
G
----
R
V
R
A
M
-----
R
N
E
---------
L
--------
G
-------------
Q
E
V
--
L
--
E
----
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
R
E
V
K
L
A
R
-------------
Q
Q
K
---------
S
--
K
L
--------------
E
N
M
F
A
-
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
I
G
L
A
------
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
---------------------------------
2
PsiBlast_PDB
74.78
51%
11
- C2 -
-
5ME1
-
IF2_ECOLI
W:
[382-882]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DT
G
A
A
A
E
----
P
R
A
P
V
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
D
Y
I
R
S
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
Y
--------
H
V
E-----------------
T
E
------------------
N
------------------
G
-
M
I
T
----------
F
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
V
V
V
A
V
N
K
I
D
K
-
P
E
--------------------------
A
-
D
--------------------------
P
--------------------------
D
-------------------------
R
V
-----------
K
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
W
------
G
------
G
E
S
Q
F
------
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
--
L
L
Q
A
E
--
V
---
L
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
I
V
L
C
G
F
----
E
----
Y
G
----
R
V
R
A
M
-----
R
N
E
---------
L
--------
G
-------------
Q
E
V
--
L
--
E
----
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
R
E
V
K
L
A
R
-------------
Q
Q
K
---------
S
--
K
L
--------------
E
N
M
F
A
-
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
I
G
L
A
------
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
---------------------------------
124
HHSearch
72.39
41%
-3
- C2 -
-
3J4J
-
IF2_THET8
A:
[3-568]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
A
Y
K
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
E
--------
K
L
-
A
----
E
E
E
R
R
K
S
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
K
A-----------
R
A
P
---------
A
--
T
M
--------------
A
A
L
L
A
-
A
M
A
E
E
G
--
A
K
E
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
A
T
-
T
E
D
V
K
I
N
I
L
A
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
A
R
E
P
Q
Y
---
K
E
-----
E
V
L
G
Q
A
------
E
V
R
----
A
--
I
F
R
L
P
T
---
G
K
Q
V
A
G
C
M
V
T
Q
G
R
I
P
R
N
A
E
V
R
V
L
R
D
G
Q
V
I
W
Q
G
R
I
A
S
L
K
R
F
K
E
D
V
R
E
V
A
Q
G
Y
E
C
G
I
G
L
D
G
-
F
----
D
D
F
R
E
G
D
V
I
E
A
F
Q
M
V
E
-------------------------------
6
PsiBlast_PDB
71.38
44%
-64
- C2 -
-
4KJZ
1
IF2_THET8
A:
[68-469]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
------
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
-----------
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
P
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
-------------
K
A
R
---------
R
PR
T
M
--------------
A
E
L
L
R
-
A
M
Q
E
E
G
--
R
K
E
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
E
S
-
T
E
D
V
K
I
N
I
L
L
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Fugue
70.69
42%
-93
- C2 -
-
4B3X
3
IF2_THET8
A:
[1-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
-
A
Y
K
-
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
E
K
L
A
E
E
E
R
-----------
R
K
S
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
G
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
-------------
K
A
R
---------
R
PR
T
M
--------------
A
E
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.59
44%
-68
- C2 -
-
4KJZ
1
IF2_THET8
C:
[68-473]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
----------
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
P
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
-------------
K
A
R
---------
R
PR
T
M
--------------
A
E
L
L
R
-
A
M
Q
E
E
G
--
R
K
E
L
N
L
I
L
R
A
D
T
Q
G
S
L
E
A
I
Q
H
I
L
A
R
E
S
-----
K
I
N
I
L
L
A
Q
V
G
A
P
T
E
S
D
V
L
L
A
Q
T
------
A
------
N
------
A
A
I
L
A
F
G
V
N
P
P
G
S
V
K
K
K
A
E
E
K
G
V
L
L
K
T
F
R
I
I
Y
D
L
V
D
E
V
R
N
M
V
K
G
Q
R
E
P
Q
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.99
51%
-102
- C2 -
-
4B48
1
IF2_THET8
A:
[69-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
A
------
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.94
51%
-104
- C2 -
-
4B47
1
IF2_THET8
A:
[69-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
------
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.37
51%
-107
- C2 -
-
4B44
1
IF2_THET8
A:
[69-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
A
------
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.99
50%
-95
- C2 -
-
4B3X
2
IF2_THET8
A:
[69-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
G
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
H
E
A
F
T
T
I
R
Q
R
G
A
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.64
50%
-106
- C2 -
-
4B43
2
IF2_THET8
A:
[69-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
L
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
A
E
A
---------
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
63.77
55%
-52
- C2 -
-
1ZO1
-
IF2_ECOLI
I:
[225-723]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
A
P
V
V
T
I
M
G
H
V
D
H
G
K
T
S
L
L
E
Y
I
R
S
T
K
V
A
S
G
E
A
G
G
I
T
Q
H
I
G
A
Y
--------
H
V
------------------
E
T
------------------
E
------------------
N
G
M
I
T
----------
F
L
D
T
P
G
H
A
A
F
T
S
M
R
A
R
G
A
Q
A
T
D
I
V
V
L
V
V
A
A
D
D
G
V
M
P
Q
T
I
E
A
I
Q
H
A
K
A
A
Q
V
P
V
V
V
A
V
N
K
I
D
K
-
P
E
--------------------------
A
-
D
--------------------------
P
--------------------------
D
-------------------------
R
V
-----------
K
N
E
L
S
Q
Y
G
I
L
P
------
E
------
E
W
------
G
------
G
E
S
Q
F
------
V
H
V
S
A
K
A
G
T
G
I
D
E
L
L
D
A
I
--
L
L
Q
A
E
--
V
---
L
E
L
K
A
V
R
K
G
M
A
S
G
A
V
I
E
S
F
L
D
K
G
R
G
P
V
A
T
V
L
V
R
E
G
T
L
H
K
G
D
I
V
L
C
G
F
----
E
----
Y
G
----
R
V
R
A
M
-----
R
N
E
---------
L
--------
G
-------------
Q
E
V
--
L
--
E
----
A
G
--
P
S
I
P
V
E
I
L
G
L
S
G
V
P
A
A
G
D
E
V
T
V
V
R
D
E
K
K
A
R
E
V
A
L
Y
R
Q
G
K
F
R
E
V
K
L
A
R
-------------
Q
Q
K
---------
S
--
K
L
--------------
E
N
M
F
A
-
N
M
T
E
G
E
--
V
H
E
V
N
I
V
L
K
A
D
V
Q
G
S
V
E
A
I
S
D
S
L
L
K
L
S
-
T
D
E
V
K
V
K
I
I
G
S
G
V
G
G
I
T
E
T
D
A
T
L
A
A
A
------
S
------
N
------
A
I
L
V
G
F
N
V
R
A
D
A
S
A
R
K
V
I
E
A
E
S
L
D
L
R
Y
Y
S
V
I
Y
N
L
I
D
E
V
K
A
A
M
S
G
M
L
S
P
E
L
---
K
Q
-----
Q
I
I
G
L
A
------
E
V
R
----
D
--
V
F
K
S
P
K
---
F
G
A
I
A
G
C
M
V
T
E
G
V
V
K
R
H
N
P
I
R
V
L
R
D
N
V
V
I
Y
E
G
E
L
E
S
L
R
R
F
K
D
D
V
N
E
V
R
N
G
M
E
C
G
I
G
V
K
N
-
Y
----
N
D
V
R
T
G
D
V
I
E
V
F
E
I
I
E
I
Q
R
----------------------------
129
HHSearch
62.57
32%
22
- C2 -
-
1G7S
1
IF2P_METTH
A:
[2-556]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
S
P
I
V
S
V
L
G
H
V
D
H
G
K
T
T
L
L
D
H
I
R
G
S
A
V
A
S
R
----
I
T
Q
H
I
G
A
T
--------
E
I
------------------
P
M
------------------
D
V
I
E
G
I
C
GDFLKKFSIRET
L
P
G
L
F
----------
F
I
D
T
P
G
H
E
A
F
T
T
L
R
K
R
G
G
A
L
A
D
L
A
I
L
I
V
D
I
N
E
G
F
K
P
Q
T
Q
E
A
L
N
I
L
R
M
Y
R
T
P
F
V
V
A
A
N
K
I
D
R
-
I
H
--------------------------
G
-
W
RVHEGRP
F
M
E
T
F
S
K
QD
I
Q
V
Q
Q
K
L
D
T
K
V
--------------------------
Y
-------------------------
E
L
-----------
V
G
K
L
H
E
E
G
F
E
S
------
E
RFDRVT
D
F
------
A
------
S
Q
V
S
I
------
I
P
I
S
A
I
T
G
E
G
I
P
E
L
L
T
M
L
--
M
G
L
A
Q
--
Q
YLR
E
Q
L
K
I
E
E
D
S
P
A
R
G
T
I
L
E
V
K
E
E
T
G
L
G
M
T
I
D
A
V
I
Y
D
G
I
L
R
K
D
D
T
I
A
M
M
T
----
S
K
D
V
I
S
T
----
R
I
R
S
L
-----
L
K
P
---------
R
--------
P
LESRKK
F
------
Q
K
V
--
D
--
E
----
V
V
AA
A
G
I
K
I
V
A
P
G
I
D
D
V
-
M
A
G
S
P
L
R
V
V
T
D
P
E
K
V
R
E
E
I
L
S
E
I
----------------------------------------------------------
E
-
D
-
I
K
I
D
--
T
D
E
A
G
V
V
V
K
A
D
T
L
G
S
L
E
A
V
V
K
I
L
R
D
M
------
Y
V
P
I
K
V
A
D
I
G
D
V
S
R
R
D
V
V
N
A
G
I
------
A
L
Q
E
DRV
Y
------
G
A
I
I
A
F
N
V
K
V
I
P
S
A
A
Q
E
L
K
N
S
D
I
K
L
F
Q
G
N
V
I
Y
R
L
M
E
E
Y
E
E
W
V
R
G
I
E
E
E
K
K
K
K
W
M
E
-----
A
I
I
K
P
A
------
S
I
R
LIPK
L
--
V
F
R
Q
S
K
----
P
A
I
G
G
V
E
V
L
T
G
V
I
R
Q
G
Y
P
L
M
N
-
D
D
G
E
T
V
--
G
T
V
E
S
M
Q
D
K
G
E
N
L
K
S
A
S
R
G
Q
K
V
A
M
A
I
K
D
-
A
VYG-
K
T
I
H
E
G
D
T
L
Y
V
D
I
P
E
N
-------------------------------
134
HHSearch
62.17
43%
-32
- C2 -
-
4B43
4
IF2_THET8
A:
[3-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
A
Y
K
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
E
K
--------
L
A
-----
E
E
E
R
R
K
S
L
P
R
R
P
P
V
V
V
I
M
G
H
V
D
H
G
L
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
A
G
G
I
T
Q
H
V
G
A
F
--------
E
V
------------------
K
T
------------------
P
------------------
Q
G
T
V
V
----------
F
I
D
T
P
G
A
E
A
---------
K
V
A
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
A
K
L
I
F
A
I
N
K
I
D
L
-
P
Q
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
R
Q
L
M
E
R
G
F
V
P
------
E
------
E
Y
------
G
------
G
D
A
I
V
------
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
--
L
L
L
A
E
--
L
---
E
D
Y
R
A
D
P
N
A
E
P
R
G
V
I
L
E
S
K
L
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
G
T
F
R
V
G
D
Y
V
V
A
G
E
----
A
----
Y
G
----
R
I
R
A
M
-----
M
D
A
---------
D
--------
G
-------------
N
Q
R
--
K
--
E
----
A
G
--
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
P
D
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
61.97
46%
10
- C6 -
-
3IZY
-
IF2M_BOVIN
P:
[178-713]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
S
P
V
V
T
I
M
G
H
V
D
H
G
K
T
T
L
L
D
K
L
R
K
T
Q
V
A
A
M
E
A
G
G
I
T
Q
H
I
G
A
F
--------
L
V
------------------
S
L
------------------
P
S-----------------
G
E
K
I
T
----------
F
L
D
T
P
G
H
A
A
F
S
A
M
R
A
R
G
T
Q
V
T
D
I
V
I
L
V
V
A
A
D
D
G
V
M
K
Q
T
V
E
S
I
Q
H
A
K
D
A
H
V
P
I
V
L
A
I
N
K
C
D
K
-
A
E
--------------------------
A
-
D
--------------------------
P
--------------------------
E
-------------------------
K
V
-----------
K
K
E
L
L
A
Y
D
V
V
C
------
E
------
D
Y
------
G
------
G
D
V
Q
A
------
V
H
V
S
A
L
T
G
E
N
M
M
A
L
A
E
A
T
--
I
A
L
A
E
--
M
---
L
E
L
K
A
D
P
T
G
A
V
E
G
T
V
I
E
S
F
T
D
K
G
R
G
P
V
T
T
A
I
I
Q
R
G
T
L
R
K
G
S
I
L
V
A
G
K
----
S
----
W
A
----
K
V
R
L
M
-----
F
D
E
---------
N
--------
G
-------------
R
A
V
--
N
--
E
----
A
Y
--
P
S
M
P
V
G
I
I
G
W
R
D
L
P
S
A
G
D
E
I
L
E
V
E
S
E
P
R
A
R
E
V
V
D
W
R
K
Y
E
Q
E
Q
E
K
N
K
E
DLKLIEEKRKEHQ
E
A
H
RKDREKYGT
V
--
H
W
KERSYIKYREKRQQ
Q
P
L
K
P
K
E
K
L
E
R
D
--
S
N
V
L
P
V
I
V
K
G
D
V
D
G
S
V
E
A
I
L
N
V
M
D
T
Y
D
A
S
H
E
C
E
L
D
L
V
H
F
G
V
G
D
I
S
E
N
D
V
N
L
A
E
T
------
F
------
H
------
G
V
I
Y
G
F
N
V
N
A
G
N
V
I
Q
Q
L
A
A
K
K
G
V
K
I
K
L
H
K
I
I
Y
R
L
I
E
D
L
Q
E
E
L
S
S
R
L
P
C
I
V
---
E
E
-----
H
P
I
G
E
A
------
S
I
L
----
A
--
T
F
S
I
T
E
GKK
K
V
P
V
A
G
C
R
V
Q
K
G
Q
I
E
K
Q
K
K
F
K
L
I
R
N
G
H
V
I
W
K
G
S
L
I
S
L
K
H
H
K
D
D
T
S
V
V
K
T
G
M
D
C
G
L
S
L
D
E
E
K
----
I
E
F
K
V
G
D
A
I
I
C
Y
E
----------------------------------
156
Fugue
61.88
29%
16
- C2 -
-
1G7S
1
IF2P_METTH
A:
[1-587]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
R
S
P
I
V
S
V
L
G
H
V
D
H
G
K
T
T
L
L
D
H
I
R
G
S
A
V
A
----
S
R
I
T
Q
H
I
G
A
T
--------
E
I
P
M
D
V
I
E
G
I
C
GDFLKKFSI
R
E
------------------
T
------------------
L
P
G
L
F
----------
F
I
D
T
P
G
H
E
A
F
T
T
L
R
K
R
G
G
A
L
A
D
L
A
I
L
I
V
D
I
N
E
G
F
K
P
Q
T
Q
E
A
L
N
I
L
R
M
Y
R
T
P
F
V
V
A
A
N
K
I
D
R
-
I
H
GWRVHEGRP
F
M
E
T
F
S
K
QD
I
Q
V
Q
Q
K
L
D
T
-
K
--------------------------
V
--------------------------
Y
-------------------------
E
L
-----------
V
G
K
L
H
E
E
G
F
E
S
------
E
------
R
F
------
D
RVTDFA
S
Q
V
S
I
------
I
P
I
S
A
I
T
G
E
G
I
P
E
L
L
T
M
L
--
M
G
L
A
Q
--
Q
YLR
E
Q
L
K
I
E
E
D
S
P
A
R
G
T
I
L
E
V
K
E
E
T
G
L
G
M
T
I
D
A
V
I
Y
D
G
I
L
R
K
D
D
T
I
A
M
M
T
S
K
D
V
I
----
S
T
----
R
I
R
S
L
-----
L
K
P
RPLESRKK
F
Q
--------
K
-------------
V
D
E
--
V
--
V
----
A
A
--
A
G
I
K
I
V
A
P
G
I
D
D
V
M
-
A
G
S
P
L
R
V
V
T
D
P
E
K
V
R
E
E
I
L
S
E
I
E
D
I
K
I
D
T
D
E
A
-------------
G
-------------------------------------------------
V
V
V
K
A
D
T
L
G
S
L
E
A
V
V
K
I
L
R
D
------
M
Y
V
P
I
K
V
A
D
I
G
D
V
S
R
R
D
V
V
N
A
G
I
------
A
L
Q
E
DRV
Y
------
G
A
I
I
A
F
N
V
K
V
I
P
S
A
A
Q
E
L
K
N
S
D
I
K
L
F
Q
G
N
V
I
Y
R
L
M
E
E
Y
E
E
W
V
R
G
I
E
E
E
K
K
---
K
K
-----
W
M
E
A
I
I
K
P
A
S
I
R
L
I
P
----
K
--
L
V
F
R
Q
S
---
K
P
A
I
G
G
V
E
V
L
T
G
V
I
R
Q
G
Y
P
L
M
N
D
D
G
E
T
V
---
G
T
V
E
S
M
Q
D
K
G
E
N
L
K
S
A
S
R
G
Q
K
V
A
M
A
I
K
D
-
A
VYG-
K
T
I
H
E
G
D
T
L
Y
V
D
I
P
E
N
H
Y
H
ILKEQLLT
D
E
E
L
D
L
M
D
K
I
A
E
I
K
R
K
KNPD
8
PsiBlast_PDB
61.79
71%
-127
- C3 -
-
2LKD
1
A:
[3-178]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
E
R
P
P
V
V
T
I
M
G
H
V
D
H
G
K
T
T
L
L
D
A
I
R
H
S
K
V
T
E
Q
E
A
G
G
I
T
Q
H
I
G
A
Y
--------
Q
V
------------------
T
V
------------------
N
------------------
D
K
K
I
T
----------
F
L
D
T
P
G
H
E
A
F
T
T
M
R
A
R
G
A
Q
V
T
D
I
V
I
L
V
V
A
A
D
D
G
V
M
P
Q
T
V
E
A
I
N
H
A
K
A
A
N
V
P
I
I
V
A
I
N
K
M
D
K
-
P
E
--------------------------
A
-
N
--------------------------
P
--------------------------
D
-------------------------
R
V
-----------
M
Q
E
L
M
E
Y
N
L
V
P
------
E
------
E
W
------
G
------
G
D
T
I
F
------
C
K
L
S
A
K
T
K
E
G
L
D
H
L
L
E
M
I
--
L
L
V
S
E
--
M
---
E
E
L
K
A
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
61.71
29%
-5
- C2 -
-
4N3S
1
IF2P_YEAST
B:
[6-456]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
L
R
S
P
I
C
C
I
L
G
H
------
K
L
L
D
K
I
R
Q
T
N
V
Q
G
G
----
I
T
Q
Q
I
G
A
T
--------
Y
F
------------------
P
I
------------------
D
A
I
K
A
K
T
K
VMAEY
E
K
Q
T
F
D
V
P
G
L
L
----------
V
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
I
D
I
M
H
G
L
E
Q
Q
T
I
E
S
I
K
L
L
R
D
R
K
A
P
F
V
V
A
L
N
K
I
D
R
-
L
Y
--------------------------
D
-
W
KAIPNNS
F
R
D
S
F
A
K
QS
R
A
V
Q
E
E
F
Q
S
R
Y
--------------------------
S
-------------------------
K
I
-----------
Q
L
E
L
A
E
Q
G
L
N
S
------
E
------
L
Y
FQNKNM
S
------
K
Y
V
S
I
------
V
P
T
S
A
V
T
G
E
G
V
P
D
L
L
W
L
L
--
L
E
L
T
Q
--
K
R--
M
S
K
Q
L
M
Y
L
S
H
V
E
A
T
I
L
E
V
K
V
V
E
G
F
G
T
T
I
D
V
I
L
S
N
G
Y
L
R
E
G
D
R
I
V
L
C
G
MN
G
P
I
----
V
T
----
N
I
R
A
L
-----
L
T
P
---------
Q
--------
P
L
R
E
L
R
L
K
SE
Y
V
H
H
K
E
V
--
K
--
A
----
A
L
---
G
V
K
I
A
A
N
D
L
E
K
-
A
V
S
G
S
R
L
L
V
V
G
P
E
D
D
E
D
E
L
M
D
D
V
M
D
-------------------------------------
D
L
--------------
T
G
L
L
----
D
S
V
D
--
T
T
G
K
G
V
V
V
Q
A
S
T
L
G
S
L
E
A
L
L
D
F
L
K
D
M
------
K
I
P
V
M
S
I
G
L
G
P
V
Y
K
R
D
V
M
K
A
S
T
MLEKAP
E
------
Y
------
A
V
M
L
C
F
D
V
K
V
D
K
E
A
E
Q
Y
A
E
Q
E
G
I
K
I
F
N
A
D
V
I
Y
H
L
F
D
S
F
T
A
Y
Q
E
K
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
61.62
32%
28
- C2 -
-
5FG3
1
IF2P_AERPE
A:
[13-567]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
Q
P
I
V
V
V
L
G
H
V
D
H
G
K
T
T
L
L
D
K
I
R
R
T
A
V
A
A
K
E
A
G
G
I
T
Q
H
I
G
A
S
--------
I
V
------------------
P
A
------------------
D
V
I
E
K
I
A
E
PLKKV
I
P
V
K
L
V
I
P
G
L
L
----------
F
I
D
T
P
G
H
E
L
F
S
N
L
R
R
R
G
G
S
V
A
D
F
A
I
L
V
V
D
I
M
E
G
F
K
P
Q
T
Y
E
A
L
E
L
L
K
E
R
R
V
P
F
L
I
A
A
N
K
I
D
R
-
I
P
--------------------------
G
W
K
--------------------------
P
NP------------------------
D
AP
F
I
E
T
I
R
R
QD
P
-------------
K
V
R
E
I
L
E
Q
R
V
Y
E
I
V
G
K
M
Y
E
A
G
L
P
A
E
LFTRI
K
------
D
F
------
R
------
R
K
I
A
I
------
V
P
V
S
A
R
T
G
E
G
I
P
E
L
L
A
V
L
--
A
G
L
T
Q
T
Y
L
---
K
E
R
L
R
Y
A
E
G
P
A
K
G
V
V
L
E
V
K
E
M
Q
G
F
G
T
V
V
D
A
V
I
Y
D
G
V
L
K
K
E
D
I
I
V
V
G
G
----
R
E
G
P
I
V
T
----
R
V
R
A
L
-----
L
M
P
---------
A
--------
P
LQDIRSREA
R
F
--
V
Q
V
--
D
--
R
VY--
A
A
--
A
G
V
R
I
A
A
P
G
L
D
D
V
-
I
A
G
S
P
I
Y
A
A
E
S
E
E
E
A
R
K
L
M
E
A
V
Q
R
E
I
--
E
-------------------------------------------------
E
L
------
R
F
R
--
T
E
N
I
G
V
V
V
K
A
D
T
L
G
T
L
E
A
L
V
E
A
L
R
R
R
------
G
V
P
V
R
L
A
D
I
G
P
V
S
R
S
D
V
L
D
A
A
V
------
T
------
R
K
I
DPYL
G
V
V
L
A
F
N
V
K
V
L
P
E
A
E
E
E
A
S
R
A
G
V
K
I
F
R
E
S
M
I
Y
K
L
I
E
D
Y
E
E
W
V
K
K
E
K
E
A
E
R
---
L
K
A
L
N
SL
I
R
P
G
K
F
------
R
I
L
----
P
GY
V
F
R
R
S
D
----
P
A
I
V
G
V
E
V
L
G
G
V
I
R
P
G
Y
P
V
M
D
S
Q
G
-
R
--
E
L
G
R
I
M
A
I
K
D
R
D
R
S
L
E
E
A
R
L
G
A
A
V
A
V
S
I
Q
G
-
R
ILIG
R
H
A
N
E
G
D
I
L
Y
T
N
V
P
A
Q
-------------------------------
14
PsiBlast_PDB
59.80
32%
25
- C2 -
-
5FG3
1
IF2P_AERPE
A:
[15-459]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
I
V
V
V
L
G
H
V
D
H
G
K
T
T
L
L
D
K
I
R
R
T
A
V
A
A
K
E
A
G
G
I
T
Q
H
I
G
A
S
I
V
P
A
D
V
I
E
K
I
------------------
A
E
------------------
P
------------------
L
K
K
V
I
P
V
K
L
VIP
G
L
L
F
I
D
T
P
G
H
E
L
F
S
N
L
R
R
R
G
G
S
V
A
D
F
A
I
L
V
V
D
I
M
E
G
F
K
P
Q
T
Y
E
A
L
E
L
L
K
E
R
R
V
P
F
L
I
A
A
N
K
I
D
R
I
P
G
--------------------------
W
-
K
--------------------------
P
--------------------------
N
PDAP
F
I
E
T
I
R
R
QD
P
K
V
R
E
I
L
E
Q
R
V
Y
E
I
-----------
V
G
K
M
Y
E
A
G
L
P
A
------
E
------
L
F
------
T
------
R
I
K
D
F
RR
K
I
A
I
V
P
V
S
A
R
T
G
E
G
I
P
E
L
L
A
V
L
A
G
L
T
Q
T
Y
--
L
---
K
E
R
L
R
Y
A
E
G
P
A
K
G
V
V
L
E
V
K
E
M
Q
G
F
G
T
V
V
D
A
V
I
Y
D
G
V
L
K
K
E
D
I
I
V
V
G
G
----
R
----
E
G
P
I
V
T
R
V
R
A
L
L
M
P
AP
L
Q
D
---------
I
RSRE----
A
-------------
R
F
V
--
Q
--
V
DRVY
A
A
--
A
G
V
R
I
A
A
P
G
L
D
D
V
-
I
A
G
S
P
I
Y
A
A
E
S
E
E
E
A
R
------------
K
L
M
E
A
-------------
V
Q
R
---------
E
--
I
E
--------------
E
L
R
F
R
-
T
--------
E
N
I
G
V
V
V
K
A
D
T
L
G
T
L
E
A
L
V
E
A
L
R
R
----
R
G
V
P
V
R
L
--
A
D
I
G
P
V
S
R
S
D
V
L
D
A
A
V
------
T
------
R
K
I
DPYL
G
V
V
L
A
F
N
V
K
V
L
P
E
A
E
E
E
A
S
R
A
G
V
K
I
F
R
E
S
M
I
Y
K
L
I
E
D
Y
E
E
W
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
50.72
32%
-5
- C2 -
-
4TMW
1
B:
[5-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
N
L
R
S
P
I
C
C
I
L
G
H
V
D
T
G
K
T
K
L
L
D
K
I
R
Q
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
--------
Y
F
------------------
P
V
E
A
I
K
Q
K
T
AVVNKDGK
F
E
F
K
------------------
V
P
G
L
L
----------
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
F
V
V
A
L
N
K
I
D
R
-
L
Y
--------------------------
G
-
W
--------------------------
K
K
I
E
NNG
F
R
E
S
F
A
L
QN
K
A
V
Q
N
E
F
R
N
R
L
D
-------------------------
Q
V
-----------
K
L
Q
F
A
E
Q
G
F
N
S
------
E
------
L
F
YENKNF
A
------
R
Y
V
S
L
------
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
--
V
Q
L
C
Q
--
E
R--
M
A
S
S
L
M
Y
L
S
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----
L
E
G
P
I
K
T
----
N
I
R
A
L
-----
L
T
P
---------
A
PMRELR
I
K
G
-------------
Q
Y
I
H
H
K
EV
K
----
A
A
--
Q
G
V
K
I
S
A
P
G
L
E
G
A
-
I
A
G
S
R
L
L
V
V
G
P
D
D
D
E
E
E
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
48.79
32%
-4
- C2 -
-
4TMX
8
IF2P_CHATD
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
N
L
R
S
P
I
C
C
I
L
G
H
V
N
T
G
K
T
K
L
L
D
K
I
R
Q
T
N
V
Q
E
G
E
A
G
G
I
T
Q
Q
I
G
A
T
--------
Y
F
------------------
P
V
E
A
I
K
Q
K
T
AVVNKDGKFEF
K
------------------
V
P
G
L
L
----------
I
I
D
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
S
L
C
N
I
A
I
L
V
V
D
I
M
H
G
L
E
P
Q
T
I
E
S
L
R
L
L
R
E
R
K
T
P
F
V
V
A
L
N
K
I
D
R
-
L
Y
--------------------------
G
-
W
--------------------------
K
K
I
E
NNG
F
R
E
S
F
A
L
QN
K
A
V
Q
N
E
F
R
N
R
L
D
-------------------------
Q
V
-----------
K
L
Q
F
A
E
Q
G
F
N
S
------
E
------
L
F
YENKNF
A
------
R
Y
V
S
L
------
V
P
T
S
A
H
T
G
E
G
I
P
D
M
L
K
L
I
--
V
Q
L
C
Q
--
E
R--
M
A
S
S
L
M
Y
L
S
E
L
Q
A
T
V
L
E
V
K
A
I
E
G
F
G
V
T
I
D
V
I
L
S
N
G
I
L
R
E
G
D
R
I
V
L
C
G
----
L
E
G
P
I
K
T
----
N
I
R
A
L
-----
L
T
P
APMRELRI-
K
--------
G
-------------
Q
Y
I
H
H
K
EV
K
----
A
A
--
Q
G
V
K
I
S
A
P
G
L
E
G
A
-
I
A
G
S
R
L
L
V
V
G
P
D
D
D
E
E
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------