@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0509: (2017-12-23 )
MLISYKWLKELVDIDVPSQELAEKMSTTGIEVEGVESPAAGLSKIVVGEVLSCEDVPETHLHVCQVNVGEEERQIVCGAPNVRAGIKVMVALPGARIADNYKIKKGKIRGLESLGMICSLGELGISDSVVPKEFADGIQILPEDAVPGEEVFSYLDLDDEIIELSITPNRADALSMCGVAHEVAAIYDKAVNFKEFTLTETNEAAADALSVSIETDKAPYYAARILDNVTIAPSPQWLQNLLMNEGIRPINNVVDVTNYILLYFGQPMHAFDLDNFEGTDIRVREARAGEKLVTLDGEERDLDVNDLVITVADKPVALAGVMGGQATEISEKSSRVVLEAAVFNGKSIRKTSGRLNLRSESSSRFEKGINVATVNEALDAAASLIAELAGATVRKGIVSAGELDTSDVEVSSTLADVNRVLGTELSYADVEDVFRRLGFGLSGNADSFTVRVPRRRWDITIEADLFEEIARIYGYDRLPTSLPKDDGTAGELTATQKLRRQVRTIAEGAGLTEIITYTLTTPEKAVEFTAQPSNLTELMWPMTVDRSVLRQNMISGILDTVAYNVARKNKNLALYEIGKVFEQTGNPKEELPNEINSFAFALTGLVAEKDFQTAAVPVDFFYAKGILEALFTRLGLQVTYTATSEIASLHPGRTAVISLGDQVLGFLGQVHPVTAKAYDIPETYVAELNLSAIEAALQPATPFVEITKFPAVSRDVALLLKAEVTHQEVVDAIQAAGVKRLTDIKLFDVFSGEKLGLGMKSMAYSLTFQNPEDSLTDEEVARYMEKIQASLEEKVNAEVR
Atome Classification :
(23 SA)
.........10........20........30........40........50.......-.-60........70...-......80........90.......-.-100.......110.......120.......130.......140..-.....150.......160.......170.......180.......190.......200..-.....210.-----.-.-..-.-.220.......230.-.......240.......250.......260.......270.......280.......290.......300.......310----..----.....320.......330.......340.......350.......360.......370.......380.......390.......400..--.....410..--..-...420.......430.......440.-...-...450.......460.......470.......480----..-.....-490.--........500.......510.......520.......530.......-540.......550.......560..--....-.570-.......580-........590.....---..600-....-...610.......620.......630....--...640........650.......660.......670.......680.-.-......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLI
S
Y
K
W
L
K
E
L
VDIDV
P
S
Q
E
L
A
E
K
MSTTG
I
E
V
E
GVESP
A
A
G
L
S
K
I
V
V
GEVLSCEDVPE-T-
H
L
H
V
C
Q
VNVGE-EE
R
-
Q
I
V
CGAPNVRAG
I
K
V
M
V
ALPGARIA-D-N
Y
K
IKKGKIR
G
L
E
S
L
G
M
I
C
S
L
G
ELGISDSVV
P
K
E
FADG
I
Q
ILPED-AV
P
G
E
E
V
F
S
Y
LDLDD
E
I
I
E
L
S
ITPNR
A
D
A
L
S
M
C
G
V
A
H
E
V
A
A
I
Y
D
KAVN
F
K
E
F
T
LTETNEA-AA
D
A
L
S
V
S
I
-----E-T-DK-A-
P
Y
Y
A
A
R
I
LDNVTI-A-P
S
P
Q
W
L
Q
N
L
L
M
NEGIR
P
I
N
N
V
V
D
V
T
N
Y
I
L
L
YFGQP
M
H
A
F
DLDNFEGT
D
I
R
V
R
EARAG
E
K
L
V
T
LDGEERDLDV
N
D
L
V
I
T
VA----DK----
P
V
A
L
A
GVMGGQATEISEKS
S
R
V
V
L
E
A
A
VFNGKSIRKTS
G
R
L
N
LRSES
S
S
R
F
E
KGIN
V
A
T
V
N
E
A
L
D
A
A
A
S
L
I
A
E
L
A
G
A
T
V
R
K
G
I
VSAGELD--TSDV
E
V
S
S
T
L
--
A
D
-
V
N
R
V
LGTELSYA
D
V
E
D
V
F
R
RLGFGLSG-NA
D
-
S
F
T
V
RVPR
R
R
W
D
I
T
I
E
A
D
L
F
E
E
I
A
R
I
YGYDRLPTSL----PK-DDGTA-G--
E
--
L
T
A
T
Q
K
L
R
R
Q
V
R
T
I
AEGAG
L
T
E
I
I
T
Y
T
LTTP
E
K
A
V
E
FTAQPSN
L
T
E
L
M-WPMTV
D
R
S
V
L
R
Q
N
M
I
S
G
I
L
D
T
V
A
Y
N
--
V
ARK-NK
N
L
-
A
L
Y
E
I
G
K
V
F
--
E
QTGN
P
K
E
E
L
P
N
E
I
N
S
---
F
A
F
A
L
-
T
G
L
V
-AEKDFQTA
A
V
P
V
D
F
F
Y
A
K
G
I
L
E
A
L
F
T
RLG
L
--
Q
V
T
Y
T-AT
S
E
I
A
SLHPGR
T
A
V
I
S
L
G
D
Q
V
L
G
F
LGQVHPVT
A
K
AYDI
P
-
E
-
T
-
Y
V
A
E
L
N
L
S
A
I
E
A
ALQPATP
F
V
E
I
TKFPAVSR
D
V
A
L
L
L
KAEV
T
H
Q
E
V
V
D
A
I
Q
A
AGVKRL
T
D
I
K
L
F
D
VFSGEKLGL
G
M
K
S
M
A
Y
S
L
T
FQNPEDSL
T
D
E
E
V
A
R
Y
M
E
K
I
Q
A
S
L
E
E
K
VNAEVR-----
2
PsiBlast_PDB
74.14
45%
-2
- C1 -
-
2RHQ
-
SYFB_STAHJ
B:
[1-789]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
---
K
-
G
-
S
G
N
I
C
Q
V
D
I
G
E
-
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
-
G
-
G
I
K
I
K
R
A
K
L
R
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
N
V
V
P
K
A
Y
E
N
G
I
F
V
F
P
T
E
-
V
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
S
E
S
-
A
T
N
E
L
S
V
T
I
-----
D
-
N
P
E
K
-
V
-
P
Y
Y
S
A
R
V
V
K
N
V
S
I
-
E
-
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
N
G
----
Q
E
----
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
S
S
G
D
L
G
--
S
F
V
T
P
I
D
I
T
A
--
E
K
-
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
-
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
----
P
V
F
G
E
V
T
S
-
G
--
E
--
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
E
R
P
T
I
S
L
L
-
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
--
V
A
R
K
-
N
K
D
V
-
R
L
Y
E
I
G
R
V
F
----
F
G
N
G
E
G
E
L
P
D
E
V
E
Y
---
L
S
G
I
L
-
T
G
E
Y
-
V
V
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
-
A
-
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
E
G
Q
D
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
-
R
-
T
-
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
I
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
-----
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
-------------
1
PsiBlast_PDB
73.90
45%
-7
- C1 -
-
2RHS
-
SYFB_STAHJ
B:
[1-793]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
K
--------
N
I
C
Q
V
D
I
G
E
-
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
-
G
-
G
I
K
I
K
R
A
K
---
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
N
V
V
P
K
A
Y
E
N
G
I
F
V
F
P
T
E
-
V
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
S
E
S
-
A
T
N
E
L
S
V
T
I
-----
D
-
N
P
E
K
-
V
-
P
Y
Y
S
A
R
V
V
K
N
V
S
I
-
E
-
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
N
G
----
Q
E
----
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
S
S
G
D
L
G
--
S
F
V
T
P
I
D
I
T
A
--
E
K
-
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
-
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
----
P
V
F
G
E
V
T
S
-
G
--
E
--
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
E
R
P
T
I
S
L
L
-
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
--
V
A
R
K
-
N
K
D
V
-
R
L
Y
E
I
G
R
V
F
----
F
G
N
G
E
G
E
L
P
D
E
V
E
Y
---
L
S
G
I
L
-
T
G
E
Y
-
V
V
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
-
A
-
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
G
G
A
G
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
-
R
-
T
-
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
I
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
G
E
H
L
E
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
----
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
-------------
33
HHSearch
73.55
45%
-9
- C1 -
-
2RHS
-
SYFB_STAHJ
D:
[1-799]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
-------
K
L
N
I
C
Q
V
D
I
G
E
E
E
P
V
-
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
-
G
-
G
I
K
I
K
R
A
K
--
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
N
V
V
P
------
I
F
V
F
P
T
E
-
V
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
S
E
S
-
A
T
N
E
L
S
V
T
I
-----
D
N
P
-
E
K
-
V
-
P
Y
Y
S
A
R
V
V
K
N
V
S
I
-
E
-
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
N
G
----
Q
E
----
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
S
S
G
D
L
G
--
S
F
V
T
P
I
D
I
T
A
--
E
K
-
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
-
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
----
P
V
-
F
G
E
V
T
S
G
--
E
--
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
E
R
P
T
I
S
L
L
-
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
--
V
A
R
K
-
N
K
D
V
-
R
L
Y
E
I
G
R
V
F
--
F
G
N
G
E
G
E
--
L
P
D
E
V
E
Y
---
L
S
G
I
L
-
T
G
E
Y
V
V
-
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
-
A
-
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
G
G
A
G
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
---
R
T
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
I
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
G
E
H
L
E
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
Q
G
-
A
T
I
------
34
HHSearch
73.13
45%
-1
- C1 -
-
2RHQ
-
SYFB_STAHJ
B:
[1-794]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
D
N
M
I
D
Y
S
K
D
I
K
N
L
V
V
G
Y
I
Q
S
K
E
K
G
S
G
-----
N
I
C
Q
V
D
I
G
E
E
E
P
V
-
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
-
G
-
G
I
K
I
K
R
A
K
L
R
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
G
I
S
S
N
V
V
P
K
A
Y
E
N
G
I
F
V
F
P
T
E
-
V
E
P
G
T
D
A
L
T
A
L
Y
L
N
D
Q
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
S
E
S
-
A
T
N
E
L
S
V
T
I
-----
D
N
P
-
E
K
-
V
-
P
Y
Y
S
A
R
V
V
K
N
V
S
I
-
E
-
P
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
N
G
----
Q
E
----
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
S
S
G
D
L
G
--
S
F
V
T
P
I
D
I
T
A
--
E
K
-
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
T
T
L
-
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
P
S
S
L
----
P
V
-
F
G
E
V
T
S
G
--
E
--
L
T
D
R
Q
H
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
E
R
P
T
I
S
L
L
-
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
--
V
A
R
K
-
N
K
D
V
-
R
L
Y
E
I
G
R
V
F
--
F
G
N
G
E
G
E
--
L
P
D
E
V
E
Y
---
L
S
G
I
L
-
T
G
E
Y
V
V
-
N
A
W
Q
G
K
K
E
E
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
--
E
F
S
Y
K
-
A
-
G
K
I
E
G
L
H
P
G
R
T
A
I
V
S
L
E
G
Q
D
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
---
R
T
Y
V
F
E
L
N
Y
D
A
M
M
Q
V
A
V
G
Y
I
N
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
N
G
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
-----
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
E
G
-
A
T
-------
3
PsiBlast_PDB
72.60
35%
-
- C1 -
-
4P71
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
-
A
D
K
L
R
V
C
Q
V
S
N
G
S
-
E
T
F
-
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
-
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
E
N
A
------
G
L
L
E
L
P
A
D
-
A
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
Q
H
D
-
E
T
R
P
V
E
L
A
A
-----
P
-
A
--
A
-
C
-
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
D
H
----
Q
R
----
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
--
L
P
K
V
A
P
I
T
L
R
--
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
-
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
----
P
Q
-
A
R
L
A
P
-
N
--
N
--
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
T
Q
P
L
T
-
L
A
-
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
--
L
N
R
Q
-
Q
S
R
V
-
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
G
L
K
Q
E
A
M
---------
L
A
G
A
I
-
C
G
K
R
-
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
--
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
-
Q
P
V
-
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
P
K
--
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-----
4
PsiBlast_PDB
66.00
35%
-9
- C1 -
-
4P72
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
-
A
D
K
L
R
V
C
Q
V
S
N
G
S
-
E
T
F
-
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
-
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
E
N
A
------
G
L
L
E
L
P
A
D
-
A
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
Q
H
D
-
E
T
R
P
V
E
L
A
A
-----
P
-
A
--
A
-
C
-
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
D
H
----
Q
R
----
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
--
L
P
K
V
A
P
I
T
L
R
--
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
-
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
----
P
Q
-
A
R
L
A
P
-
N
--
N
--
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
T
Q
P
L
T
-
L
A
-
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
--
L
N
R
Q
-
Q
S
R
V
-
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
G
L
K
Q
E
A
M
---------
L
A
G
A
I
-
C
G
K
R
-
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
--
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
-
Q
P
V
-
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
P
K
--
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-----
6
PsiBlast_PDB
65.62
35%
-11
- C1 -
-
4P74
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
-
A
D
K
L
R
V
C
Q
V
S
N
G
S
-
E
T
F
-
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
-
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
E
N
A
------
G
L
L
E
L
P
A
D
-
A
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
Q
H
D
-
E
T
R
P
V
E
L
A
A
-----
P
-
A
--
A
-
C
-
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
D
H
----
Q
R
----
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
--
L
P
K
V
A
P
I
T
L
R
--
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
-
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
----
P
Q
-
A
R
L
A
P
-
N
--
N
--
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
T
Q
P
L
T
-
L
A
-
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
--
L
N
R
Q
-
Q
S
R
V
-
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
G
L
K
Q
E
A
M
---------
L
A
G
A
I
-
C
G
K
R
-
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
--
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
-
Q
P
V
-
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
P
K
--
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-----
7
PsiBlast_PDB
65.30
35%
-10
- C1 -
-
4P75
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
-
A
D
K
L
R
V
C
Q
V
S
N
G
S
-
E
T
F
-
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
-
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
E
N
A
------
G
L
L
E
L
P
A
D
-
A
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
Q
H
D
-
E
T
R
P
V
E
L
A
A
-----
P
-
A
--
A
-
C
-
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
D
H
----
Q
R
----
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
--
L
P
K
V
A
P
I
T
L
R
--
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
-
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
----
P
Q
-
A
R
L
A
P
-
N
--
N
--
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
T
Q
P
L
T
-
L
A
-
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
--
L
N
R
Q
-
Q
S
R
V
-
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
G
L
K
Q
E
A
M
---------
L
A
G
A
I
-
C
G
K
R
-
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
--
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
-
Q
P
V
-
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
P
K
--
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-----
36
HHSearch
65.28
34%
-12
- C1 -
-
1B7Y
-
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
--
T
V
-
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
Y
G
------
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
-
L
V
E
P
E
A
A
L
K
--
A
E
A
-
L
P
L
P
F
A
L
K
V
-----
E
D
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
GE
E
S
F
----
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
-
P
--
K
P
P
E
A
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
----
P
A
-
F
F
P
A
P
-
D
NR
G
--
V
E
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
--
L
D
L
D
R
P
E
R
A
-
L
L
F
E
V
G
R
V
F
--
R
E
R
---------
E
E
T
H
---
L
A
G
L
L
-
F
G
E
G
V
G
-
L
P
W
A
-
K
E
R
L
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
-
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
---
P
V
H
L
F
E
L
R
L
P
L
P
----
D
K
P
L
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
32
HHSearch
65.00
36%
3
- C1 -
-
4P72
-
SYFB_PSEAE
B:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
-
K
L
R
V
C
Q
V
S
N
G
S
-
E
T
F
-
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
-
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
E
N
------
A
G
L
L
E
L
P
A
D
-
A
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
-
D
A
V
-
A
A
Q
-
H
D
E
T
R
P
V
E
L
-----
A
A
P
-
A
A
-
C
-
P
R
Y
L
G
R
V
I
R
N
V
D
L
S
R
-
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
D
H
----
Q
R
----
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
-
P
I
V
E
Q
V
S
E
A
HL
P
K
V
A
P
I
T
L
R
A
--
E
R
-
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
D
G
E
G
-
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
----
P
Q
-
A
R
L
A
P
-
N
--
N
--
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
L
T
L
A
-
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
--
L
N
R
Q
-
Q
S
R
V
-
R
L
F
E
S
G
L
R
F
--
V
G
Q
L
E
G
----
L
K
Q
E
A
M
---
L
A
G
A
I
-
C
G
K
R
L
P
-
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
LG
D
F
S
F
V
-
P
-
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
-
Q
-
P
V
F
L
F
E
L
L
L
A
E
V
V
D
--
G
H
L
P
K
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-----
5
PsiBlast_PDB
64.75
35%
-6
- C1 -
-
4P73
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
A
G
A
F
S
G
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
-
A
D
K
L
R
V
C
Q
V
S
N
G
S
-
E
T
F
-
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
-
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
Q
I
S
E
E
N
A
------
G
L
L
E
L
P
A
D
-
A
P
V
G
Q
D
V
R
T
Y
L
E
L
A
D
Y
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
P
V
A
V
D
A
V
A
A
Q
H
D
-
E
T
R
P
V
E
L
A
A
-----
P
-
A
--
A
-
C
-
P
R
Y
L
G
R
V
I
R
N
V
D
L
-
S
R
P
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
D
H
----
Q
R
----
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
G
P
I
V
E
Q
V
S
E
A
H
--
L
P
K
V
A
P
I
T
L
R
--
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
V
V
A
-
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
----
P
Q
-
A
R
L
A
P
-
N
--
N
--
K
P
E
A
R
A
A
L
P
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
T
Q
P
L
T
-
L
A
-
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
--
L
N
R
Q
-
Q
S
R
V
-
R
L
F
E
S
G
L
R
F
V
G
Q
L
E
G
L
K
Q
E
A
M
---------
L
A
G
A
I
-
C
G
K
R
-
L
P
E
G
W
A
N
G
R
D
G
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
A
--
L
G
D
F
S
F
V
P
G
E
H
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
-
Q
P
V
-
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
P
K
--
F
R
E
L
S
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
A
A
G
E
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
-----
21
Fugue
64.49
34%
-3
- C1 -
-
1JJC
-
SYFB_THET8
B:
[1-785]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
--
T
V
-
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
-
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
Y
------
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
-
P
---
F
A
L
K
V
-----
E
-
D
-
P
E
G
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
-
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
GE
E
S
F
----
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
-
A
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
----
P
A
-
F
F
P
A
P
-
D
--
N
RG
V
E
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
P
P
R
L
-
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
--
L
D
L
D
-
R
P
E
R
A
L
L
F
E
V
G
R
V
F
-----------
R
E
R
E
E
T
H
---
L
A
G
L
L
-
F
G
E
G
-
V
G
L
P
W
A
K
E
R
-
L
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
----
P
D
K
P
L
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-
G
F
G
L
R
GLDTP
35
HHSearch
63.94
34%
-10
- C1 -
-
1EIY
-
SYFB_THET8
B:
[1-780]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
--
T
V
-
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
E
Y
G
------
G
G
L
L
E
F
P
E
D
A
L
P
P
G
T
P
L
S
E
A
W
P
-
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
-
L
V
E
P
E
A
A
L
K
--
A
E
A
-
L
P
L
P
F
A
L
K
V
-----
E
D
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
----
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
-
P
--
K
P
P
E
A
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
----
P
A
-
F
F
P
A
P
-
D
NR
G
--
V
E
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
--
L
D
L
D
R
P
E
R
A
-
L
L
F
E
V
G
R
V
F
--
R
E
R
---------
E
E
T
H
---
L
A
G
L
L
-
F
G
E
G
V
G
-
L
P
W
A
-
K
E
R
L
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
-
Q
A
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
---
P
V
H
L
F
E
L
R
L
P
L
P
----
D
K
P
L
A
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
-
F
G
L
R
-----
11
PsiBlast_PDB
62.97
33%
-10
- C1 -
-
1B7Y
-
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
V
E
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
10
PsiBlast_PDB
62.80
33%
-9
- C1 -
-
1PYS
-
SYFB_THET8
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
V
E
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
13
PsiBlast_PDB
62.57
33%
-10
- C1 -
-
1B70
-
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
V
E
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
17
PsiBlast_PDB
61.94
33%
-8
- C1 -
-
2AMC
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
VE
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
8
PsiBlast_PDB
61.78
35%
9
- C1 -
-
3PCO
-
SYFB_ECOLI
B:
[1-794]
M
K
F
S
E
L
W
L
R
E
W
V
N
P
A
I
D
S
D
A
L
A
N
Q
I
T
M
A
G
L
E
V
D
G
V
E
P
V
A
G
S
F
H
G
V
V
V
G
E
V
V
E
C
A
Q
H
P
N
-
A
D
K
L
R
V
T
K
V
N
V
G
G
-
D
R
L
L
D
I
V
C
G
A
P
N
C
R
Q
G
L
R
V
A
V
A
T
I
G
A
V
L
P
-
G
-
D
F
K
I
K
A
A
K
L
R
G
E
P
S
E
G
M
L
C
S
F
S
E
L
G
I
S
D
D
------
H
S
G
I
I
E
L
P
A
D
-
A
P
I
G
T
D
I
R
E
Y
L
K
L
D
D
N
T
I
E
I
S
V
T
P
N
R
A
D
C
L
G
I
I
G
V
A
R
D
V
A
V
L
--
N
Q
L
P
L
V
Q
P
E
I
V
P
V
G
A
T
-
I
D
D
T
L
P
I
T
V
-----
E
-
A
-
P
E
-
A
C
P
R
Y
L
G
R
V
V
K
G
I
N
V
K
A
-
P
T
P
L
W
M
K
E
K
L
R
R
C
G
I
R
S
I
D
A
V
V
D
V
T
N
Y
V
L
L
E
L
G
Q
P
M
H
A
F
D
K
D
R
I
E
G
G
-
I
V
V
R
M
A
K
E
G
E
T
L
V
L
L
D
G
T
E
A
K
L
N
A
D
T
L
V
I
A
D
H
----
N
K
----
A
L
A
M
G
G
I
F
G
G
E
H
S
G
V
N
D
E
T
Q
N
V
L
L
E
C
A
F
F
S
P
L
S
I
T
G
R
A
R
R
H
G
L
H
T
D
A
S
H
R
Y
E
R
G
V
D
P
A
L
Q
H
K
A
M
E
R
A
T
R
L
L
I
D
I
C
G
G
E
A
G
P
V
I
D
I
T
N
E
A
---
T
L
P
K
R
A
T
I
T
L
R
R
S
K
-
L
D
R
L
I
G
H
H
I
A
D
E
Q
V
T
D
I
L
R
R
L
G
C
E
V
T
E
-
G
K
D
-
E
W
Q
A
V
A
P
S
W
R
F
D
M
E
I
E
E
D
L
V
E
E
V
A
R
V
Y
G
Y
N
N
I
P
D
E
P
----
V
Q
-
A
S
L
I
M
-
G
--
T
--
H
R
E
A
D
L
S
L
K
R
V
K
T
L
L
N
D
K
G
Y
Q
E
V
I
T
Y
S
F
V
D
P
K
--
V
Q
Q
M
I
H
P
G
V
E
A
L
L
L
P
S
P
I
S
V
E
M
S
A
M
R
L
S
L
W
T
G
L
L
A
T
V
V
Y
N
--
Q
N
R
Q
-
Q
N
R
V
-
R
I
F
E
S
G
L
R
F
--
V
----
P
D
T
Q
A
P
L
G
I
R
Q
D
L
M
L
A
G
V
I
-
C
G
N
R
-
Y
E
E
H
W
N
L
A
K
E
T
V
D
F
Y
D
L
K
G
D
L
E
S
V
L
D
L
T
G
K
LN
E
V
E
F
R
-
A
E
A
N
P
A
-
L
H
P
G
Q
S
A
A
I
Y
L
K
G
E
R
I
G
F
V
G
V
V
H
P
E
L
E
R
K
L
D
L
N
G
R
-
T
-
L
V
F
E
L
E
W
N
K
L
A
D
R
V
V
P
Q
A
R
--
E
I
S
R
F
P
A
N
R
R
D
I
A
V
V
V
A
E
N
V
P
A
A
D
I
L
S
E
C
K
K
V
G
V
N
Q
V
V
G
V
N
L
F
D
V
Y
R
G
K
G
V
A
E
G
Y
K
S
L
A
I
S
L
I
L
Q
D
T
S
R
T
L
E
E
E
E
I
A
A
T
V
A
K
C
V
E
A
L
K
E
R
F
Q
A
S
L
R
-----
14
PsiBlast_PDB
61.75
33%
-10
- C1 -
-
1JJC
-
SYFB_THET8
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
VE
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
16
PsiBlast_PDB
61.74
33%
-11
- C1 -
-
2ALY
-
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
VE
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
19
PsiBlast_PDB
61.70
33%
-10
- C1 -
-
3TEH
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
V
E
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
20
PsiBlast_PDB
61.28
33%
-10
- C1 -
-
4TVA
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
VE
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------
18
PsiBlast_PDB
60.47
33%
-8
- C1 -
-
3HFZ
1
SYFB_THET8
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
D
R
I
E
R
V
F
P
I
P
R
G
V
V
F
A
R
V
L
E
A
H
P
I
P
G
-
T
-
R
L
K
R
L
V
L
D
A
G
R
-
T
V
--
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
-
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
G
V
G
------
E
Y
G
G
G
L
L
E
F
P
E
D
-
A
L
P
P
G
T
P
L
S
E
A
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
--------
G
Y
A
L
V
E
P
E
A
A
L
K
A
E
A
L
P
L
P
F
A
L
K
V
E
D
-
P
-
E
G
-
A
-
P
H
F
T
L
G
Y
A
F
G
L
R
V
-
A
-
P
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
-
R
F
V
G
E
G
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
----
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
A
E
A
L
L
E
A
G
S
P
K
--
P
P
E
A
-
I
P
F
R
P
--
E
Y
-
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
V
E
G
-
E
G
P
-
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
P
L
A
L
P
A
F
F
P
A
-
P
D
N
R
G
-
V
--
E
----
A
P
Y
R
K
E
Q
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
L
L
-
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
-
E
R
A
L
--
L
F
E
V
G
R
V
F
--
R
E
----
R
E
E
--
T
H
L
A
G
---
L
L
F
G
E
G
V
G
L
P
-
W
A
K
E
R
L
S
G
-----
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
--
A
F
R
V
E
-
A
Q
A
-
F
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
-
V
-
H
L
F
E
L
R
L
P
L
P
D
K
P
L
A
----
F
Q
D
P
S
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
A
A
G
P
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
-----------