@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0531: (2017-12-24 )
MEFSMKSVKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFILATRLPLLESWFHSLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGNLAIYIFASIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRLLTFNLLSFLVGSYALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTREIQIHLSRPFNYQSGQFAFLKIFQEGFESAPHPFSISGGHGQTLYFTVKTSGDHTKNIYDNLQAGSKVTLDRAYGHMIIEEGRENQVWIAGGIGITPFISYIREHPILDKQVHFYYSFRGDENAVYLDLLRNYAQKNPNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEGFKFK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......----.190.......200...-..-----.--.210----.........220.....----------------------------..230........---240-........250----------.-----------------.......260.---------------......270-.......280.--...-...290.......---300...-....---------310.......320...-....330.......--------340....------------...350----------.---------.....----------.--..--360----------.------.---.......370.......380..-...-..------390-----.........400---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEF
S
M
K
S
V
K
G
L
L
F
I
I
A
S
F
I
L
T
L
L
T
WMNTSP
Q
F
M
IP
G
L
A
L
T
S
L
S
L
T
F
I
L
A
TR
L
P
L
L
E
S
W
F
H
S
L
E
K
V
Y
T
V
H
K
F
T
A
F
L
S
I
I
L
L
I
F
HNFSMG
G
L
W
G
S
R
L
A
A
Q
FGN
L
A
I
Y
I
F
A
S
I
I
L
V
A
Y
L
G
K
Y
I
Q
Y
E
A
W
R
W
I
H
R
L
V
Y
L
A
Y
I
L
G
L
F
H
I
Y
M
I
MGN
R
L
L
T
F
N
L
L
S
F
L
V
G
S
Y
A
L
L
G
L
L
A
G
F
Y
I
I
F
L
Y
Q
KISFPY
L
G
----
K
I
T
H
L
K
R
LNHDT
R
E
I
Q
I
-
H
L-----S--RP------FNYQSG
Q
F
A
F
L
K
I
F
Q
E
G
----------------------------
F
ES-APH
P
F
S
ISG---GH--G
Q
T
L
Y
F
T
V
KT-----------S-----------------GDH
T
K
N
I
Y
D
NL---------------QAG
S
K
V
T
L
D-RAYG
H
M
I
IEEG--RE
N
-
Q
V
W
I
AGGI
G
I
T
P
F
---
I
S
Y
I
R
E-HPIL---------D
K
Q
V
H
F
Y
Y
S
FRGDEN
A
-
V
Y
L
D
L
L
R
N
Y
A
QKNP--------
N
F
E
L
H
L
I
------------DSTK------------D---------GYLN
F
----------
E
--
Q
K--E------------V------P---EH
A
T
V
Y
M
CG
P
I
S
M
M
K
A
L
A
K
Q
I
K
-KQN-PK------
T
-------
E
LIYEGFKFK-----
23
Fugue
79.92
17%
-33
- C3 -
-
1GVH
2
HMP_ECOLI
A:
[1-396]
--------------------------------------
M
L
D
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
P
E
L
K
E
I
F
N
M
S
N
Q
R
N
G
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
I
E
N
L
P
A
L
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
Q
I
K
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
F
S
P
--
G
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
E
N
A
S
K
A
G
G
WE
G
T
R
D
F
R
I
V
A
K
T
P
R
S
A
L
I
T
S
-
F
E
-----
L
--
E
P
VDG
G
A
V
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
P
E
G
----------------------------
F
P
H
Q
E
I
R
Q
Y
S
L
T
R
KPD
G
K
--
G
Y
R
I
A
V
K
R
E
E
-----------
G
-----------------
G
Q
V
S
N
W
L
H
N
H
A
---------------
N
V
G
D
V
V
K
L
V
-
A
P
A
G
D
F
F
M
A
V
A
--
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
---
L
A
M
L
D
T
-
L
A
K
A
GH-------
T
A
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
-
A
F
A
D
E
V
K
E
L
G
Q
S
L
P
--------
R
F
T
A
H
T
W
Y
RQPS
E
A
D
R
A
K
G
Q
F
D
S
------------
E
---------
G
L
M
D
L
----------
S
--
K
L
--
E
------------
G
------
A
FSD
P
T
M
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
-
D
L
G
V
K
Q
------
E
-------
N
I
H
Y
E
C
F
G
P
H
KVL--
33
HHSearch
79.17
26%
-39
- C3 -
-
5O0X
20
?
A:
[3-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
T
----
F
V
V
N
A
S
L
L
P
S
K
V
L
G
L
Q
V
-
Q
R
-----
P
--
Q
S
------
F
N
Y
Q
P
G
D
Y
L
F
I
K
C
P
G
I
-----------------------------
S
K
F
-
E
W
H
P
F
T
I
S
S
---
A
P
EM
P
D
V
L
T
L
H
I
R
A
-----------
V
-----------------
G
S
W
T
G
K
L
Y
Q
L
I
R
E
Q
R
E
E
W
I
R
SGSSQS
L
P
G
V
P
V
Y
I
D
-
G
P
Y
G
T
P
S
T
H
I
F
E-
S
K
Y
-
A
I
L
I
C
A
G
I
G
V
T
P
F
---
A
S
I
L
K
S
-
I
L
H
R
N
Q
Q
NPAKMP
L
K
K
V
H
F
Y
W
L
N
R
E
Q
K
A
F
E
W
F
V
E
L
L
S
K
I
E
A
E
D
T
NN------
L
F
D
L
N
L
Y
------------
L
T
--LITGLK
S
R
T
K
--
T
---------
G
R
P
D
W
----------
E
--
E
I
F
K
D
------------
V
A
K
Q
H
A-
P
---
D
N
V
E
V
F
F
C
G
P
T
G
L
A
L
Q
L
R
H
L
C
T
-
K
Y
G
---------
F
-------
G
Y
R
K
E
N
F
P
W
------
43
HHSearch
66.71
23%
11
- C3 -
-
3OZV
2
HMP_CUPNH
A:
[155-398]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
F
----
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
D----
G
G
-
P
V
------
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L---------------------------
G
L
Q
-
Q
I
R
Q
Y
S
L
S
D
---
M
P
N-
G
R
S
Y
R
I
S
V
K
R
-----------
E
GGGPQPP----------
G
Y
V
S
N
L
L
H
D
H
V
---------------
N
V
G
D
Q
V
K
L
A
-
A
P
Y
G
S
F
H
I
D
V
D
A-
K
T
P
-
I
V
L
I
S
G
G
V
G
L
T
P
M
---
V
S
M
L
K
V
-
A
L
Q
A
P--------
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
-
A
M
R
D
R
L
R
E
A
A
K
T
Y
E
--------
N
L
D
L
F
V
F
------------
Y
D
Q
P
LPEDVQGRDYDY
P
---------
G
L
V
D
V
----------
K
--
Q
I
E-
K
S-----------
I
L-----
L
---
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
-
N
L
G
I
H
E
------
A
-------
R
I
H
Y
E
V
F
G
P
------
35
HHSearch
66.60
23%
8
- C3 -
-
2R6H
1
?
C:
[9-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
C
----
E
V
L
S
N
K
N
V
S
T
F
I
K
E
F
V
V
K
L
P
E----
G
--
E
T
------
M
N
F
K
S
G
S
Y
A
Q
I
K
I
P
K
Y
N
I
R
YAD
Y
D
I
Q
DRFR
G
D
W
D
K
M
DAWS
L
T
C
K
N
E
E
E
-
T
V
R
A
Y
S
M
A
N
---
Y
P
AE
G
N
I
I
T
L
N
V
R
I
-----------
A
TPPFDRAANKWK
A
G
I
K
P
G
I
S
S
S
Y
I
F
S
-
L
---------------
K
P
G
D
K
V
M
M
S
-
G
P
Y
G
D
F
H
I
Q
D
T
--
D
A
E
-
M
L
Y
I
G
G
G
A
G
M
A
P
L
---
R
A
Q
I
L
H
-
L
F
R
T
LKT------
G
R
K
V
S
Y
W
Y
G
A
R
S
K
N
E
I
-
F
Y
E
E
D
F
R
E
I
E
R
E
F
P
--------
N
F
K
F
H
I
A
------------
L
S
D
P
------------
Q
PEDNWTGYV
G
F
I
H
Q
----------
V
--
I
Y
D
-
N
------------
Y
LKDHDA
P
---
E
D
I
E
Y
Y
M
C
G
P
G
P
M
A
N
A
V
K
G
M
L
E
-
N
L
G
V
P
R
------
N
-------
M
L
F
F
D
D
F
G
-------
31
HHSearch
66.54
21%
-3
- C3 -
-
1KRH
1
BENC_ACIAD
A:
[108-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
E
G
----
T
L
A
R
V
E
N
L
S
D
S
T
I
T
F
D
I
Q
L
D
-----
D
GQ
P
D
------
I
H
F
L
A
G
Q
Y
V
N
V
T
L
P
G
-------------------------------
T
T
-
E
T
R
S
Y
S
F
S
S
---
Q
P
G-
N
R
L
T
G
F
V
V
R
N
-----------
V
PQ---------------
G
K
M
S
E
Y
L
S
V
Q
A
---------------
K
A
G
D
K
M
S
F
T
-
G
P
F
G
S
F
Y
L
R
D
V
--
K
R
P
-
V
L
M
L
A
G
G
T
G
I
A
P
F
---
L
S
M
L
Q
V
-
L
E
Q
K
GS-------
E
H
P
V
R
L
V
F
G
V
T
Q
D
C
D
L
-
V
A
L
E
Q
L
D
A
L
Q
Q
K
L
P
--------
W
F
E
Y
R
T
V
------------
V
A
H
A
------------
E
SQHERK---
G
Y
V
T
-----------
G
--
H
I
E-
Y
D-----------
W
LN----
G
---
G
E
V
D
V
Y
L
C
G
P
V
P
M
V
E
A
V
R
S
W
L
D
-
T
Q
G
I
Q
P
------
A
-------
N
F
L
F
E
K
F
S
A
------
36
HHSearch
65.29
23%
8
- C3 -
-
2R6H
1
?
A:
[9-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
C
----
E
V
L
S
N
K
N
V
S
T
F
I
K
E
F
V
V
K
L
P
E----
G
--
E
T
------
M
N
F
K
S
G
S
Y
A
Q
I
K
I
P
K
Y
N
I
R
YAD
Y
D
I
Q
DRFR
G
D
W
D
K
M
DAWS
L
T
C
K
N
E
E
E
-
T
V
R
A
Y
S
M
A
N
---
Y
P
AE
G
N
I
I
T
L
N
V
R
I
-----------
A
TPPFDRAANKWKAGIKP
G
I
S
S
S
Y
I
F
S
-
L
---------------
K
P
G
D
K
V
M
M
S
-
G
P
Y
G
D
F
H
I
Q
D
T
--
D
A
E
-
M
L
Y
I
G
G
G
A
G
M
A
P
L
---
R
A
Q
I
L
H
-
L
F
R
T
LKT------
G
R
K
V
S
Y
W
Y
G
A
R
S
K
N
E
I
-
F
Y
E
E
D
F
R
E
I
E
R
E
F
P
--------
N
F
K
F
H
I
A
------------
L
S
D
P
------------
Q
PEDNWTGYV
G
F
I
H
Q
----------
V
--
I
Y
D
-
N
------------
Y
LKDHDA
P
---
E
D
I
E
Y
Y
M
C
G
P
G
P
M
A
N
A
V
K
G
M
L
E
-
N
L
G
V
P
R
------
N
-------
M
L
F
F
D
D
F
G
-------
45
HHSearch
64.97
23%
20
- C3 -
-
1CQX
2
HMP_CUPNH
B:
[155-398]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
F
----
V
I
R
E
K
R
P
E
S
D
V
I
T
S
F
I
L
E
P
A
-----
D
GG
P
V
------
V
N
F
E
P
G
Q
Y
T
S
V
A
I
D
V
P
A
L---------------------------
G
L
Q
-
Q
I
R
Q
Y
S
L
S
D
---
M
P
N-
G
R
T
Y
R
I
S
V
K
R
-----------
E
GGGPQPP----------
G
Y
V
S
N
L
L
H
D
H
V
---------------
N
V
G
D
Q
V
K
L
A
-
A
P
Y
G
S
F
H
I
D
V
D
A-
K
T
P
-
I
V
L
I
S
G
G
V
G
L
T
P
M
---
V
S
M
L
K
V
-
A
L
Q
A
P--------
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
-
A
M
R
D
R
L
R
E
A
A
K
T
Y
E
--------
N
L
D
L
F
V
F
------------
Y
D
Q
P
LPEDVQGRDYDY
P
---------
G
L
V
D
V
----------
K
--
Q
I
E-
K
S-----------
I
L-----
L
---
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
-
N
L
G
I
H
E
------
A
-------
R
I
H
Y
E
V
F
G
P
------
42
HHSearch
62.69
20%
18
- C3 -
-
4U9U
1
NQRF_VIBCH
A:
[5-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
C
----
T
V
I
S
N
D
N
K
A
T
F
I
K
E
L
K
L
A
I
P
D----
G
--
E
S
------
V
P
F
R
A
G
G
Y
I
Q
I
E
A
P
A
H
H
V
K
YADFDVPEKYR
G
D
W
D
K
F
NLFR
Y
E
S
K
V
D
E
P
-
I
I
R
A
Y
S
M
A
N
---
Y
P
EE
F
G
I
I
M
L
N
V
R
I
ATPPPNNPNVP
P
-----------------
G
Q
M
S
S
Y
I
W
S
-
L
---------------
K
A
G
D
K
C
T
I
S
-
G
P
F
G
E
F
F
A
K
D
T
--
D
A
E
-
M
V
F
I
G
G
G
A
G
M
A
P
M
---
R
S
H
I
F
D
-
Q
L
K
R
LKS------
K
R
K
M
S
Y
W
Y
G
A
R
S
K
R
E
M
-
F
Y
V
E
D
F
D
G
L
A
A
E
N
D
--------
N
F
V
W
H
C
A
------------
L
S
D
P
QPEDNWTGY---
T
---------
G
F
I
H
N
----------
V
--
L
Y
E
-
N
------------
Y
LKDHEA
P
---
E
D
C
E
Y
Y
M
C
G
P
P
M
M
N
A
A
V
I
N
M
L
K
-
N
L
G
V
E
E
------
E
-------
N
I
L
L
D
D
F
G
-------
34
HHSearch
62.17
20%
24
- C3 -
-
4P6V
1
NQRF_VIBCH
F:
[132-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
C
----
T
V
I
S
N
D
N
K
A
T
F
I
K
E
L
K
L
A
I
P
D----
G
--
E
S
------
V
P
F
R
A
G
G
Y
I
Q
I
E
A
P
A
H
H
V
K
YADFDVPEKYR
G
D
W
D
K
F
NLFR
Y
E
S
K
V
D
E
P
-
I
I
R
A
Y
S
M
A
N
---
Y
P
EE
F
G
I
I
M
L
N
V
R
I
ATPPPNNPNVP
P
-----------------
G
Q
M
S
S
Y
I
W
S
-
L
---------------
K
A
G
D
K
C
T
I
S
-
G
P
F
G
E
F
F
A
K
D
T
--
D
A
E
-
M
V
F
I
G
G
G
A
G
M
A
P
M
---
R
S
H
I
F
D
-
Q
L
K
R
LKS------
K
R
K
M
S
Y
W
Y
G
A
R
S
K
R
E
M
-
F
Y
V
E
D
F
D
G
L
A
A
E
N
D
--------
N
F
V
W
H
C
A
------------
L
S
D
P
QPEDNWTGY---
T
---------
G
F
I
H
N
----------
V
--
L
Y
E
-
N
------------
Y
LKDHEA
P
---
E
D
C
E
Y
Y
M
C
G
P
P
M
M
N
A
A
V
I
N
M
L
K
-
N
L
G
V
E
E
------
E
-------
N
I
L
L
D
D
F
G
-------
47
HHSearch
60.03
17%
-6
- C3 -
-
4B4D
1
?
A:
[8-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
A
E
----
T
V
L
E
V
R
H
W
T
D
A
Y
F
S
F
T
T
-
T
R
-----
D
--
A
G
------
F
R
F
E
N
G
Q
F
V
M
I
G
L
E
T
E
-----------------------------
T
R
P
-
L
L
R
A
Y
S
I
A
S
---
A
N
W-
E
E
H
L
E
F
F
S
I
K
-----------
V
PD---------------
G
P
L
T
S
R
L
Q
H
-
I
---------------
Q
P
G
D
K
V
L
V
G
K
K
P
T
G
T
L
L
I
S
D
L
HP
G
R
N
-
L
Y
L
L
G
T
G
T
G
L
A
P
W
---
L
S
I
I
K
D
-
P
E
T
Y
E
R
-------
F
D
K
V
I
L
T
Q
G
V
R
F
V
Q
D
L
-
A
Y
R
D
Y
F
E
R
E
L
P
Q
H
E
FL
G
D
L
L
R
E
K
L
L
Y
Y
P
A
------------
V
T
R
E
TFAN--------
Q
---------
G
R
L
T
E
----------
L
--
M
A
--
D
G
R
M
Q
Q
T
L
GLP--
T
LD----
P
---
A
N
D
R
F
M
I
C
G
S
P
Q
M
L
A
D
L
R
S
L
L
D
-
S
R
G
F
Q
T
------
S
PRIGTPG
H
Y
V
F
E
R
A
--------
21
Fugue
59.29
24%
-58
- C3 -
-
1CQX
2
HMP_CUPNH
A:
[262-403]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
D
A
--
K
T
P
-
I
V
L
I
S
G
G
V
G
L
T
P
M
---
V
S
M
L
K
V
A
L
Q
A
P
---------
P
R
Q
V
V
F
V
H
G
A
R
N
S
A
V
H
-
A
M
R
D
R
L
R
E
A
A
K
T
Y
E
--------
N
L
D
L
F
V
F
Y
DQPLPEDVQGR
D
Y
D
Y
------------
P
---------
G
L
V
D
V
----------
K
QI
E
K
--
S
------------
I
------
L
L--
P
D
A
D
Y
Y
I
C
G
P
I
P
F
M
R
M
Q
H
D
A
L
K
-
N
L
G
-
I
H
------
E
-------
A
R
I
H
Y
E
V
F
G
P
DLFAE
40
HHSearch
59.05
18%
18
* C3 *
-
1GVH
2
HMP_ECOLI
A:
[152-392]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
D
F
----
R
I
V
A
K
T
P
R
S
A
L
I
T
S
F
E
L
E
P
V
-----
D
G
G
A
V
------
A
E
Y
R
P
G
Q
Y
L
G
V
W
L
K
P
E
G
F---------------------------
P
H
Q
-
E
I
R
Q
Y
S
L
T
R
---
K
P
D-
G
K
G
Y
R
I
A
V
K
R
EE---------
G
-----------------
G
Q
V
S
N
W
L
H
N
H
A
---------------
N
V
G
D
V
V
K
L
V
-
A
P
A
G
D
F
F
M
A
V
A
D-
D
T
P
-
V
T
L
I
S
A
G
V
G
Q
T
P
M
---
L
A
M
L
D
T
-
L
A
K
A
GH-------
T
A
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
-
A
F
A
D
E
V
K
E
L
G
Q
S
L
P
--------
R
F
T
A
H
T
W
------------
Y
R
Q
P
S
E
A
D
R
A
K
GQFDS
E
---------
G
L
M
D
L
----------
S
--
K
L
E-
G
------------
A
FS----
D
---
P
T
M
Q
F
Y
L
C
G
P
V
G
F
M
Q
F
T
A
K
Q
L
V
-
D
L
G
V
K
Q
------
E
-------
N
I
H
Y
E
C
F
G
P
------
44
HHSearch
56.85
19%
10
- C3 -
-
4EH1
5
HMP_VIBCH
B:
[4-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
F
----
V
V
R
E
K
Q
V
E
S
A
Y
V
T
S
F
V
L
V
P
A
-----
D
G
G
A
V
------
L
D
Y
Q
P
G
Q
Y
I
G
I
E
V
T
P
E
G
S---------------------------
D
Y
R
-
E
I
R
Q
Y
S
L
S
H
---
A
S
N-
G
R
E
Y
R
I
S
V
K
R
-----------
E
GVGSDNP----------
G
L
V
S
H
Y
L
H
N
N
V
---------------
K
V
G
D
S
V
K
L
Y
-
A
P
A
G
D
F
F
Y
V
E
R
--
E
R
P
-
V
V
L
I
S
A
G
V
G
A
T
P
M
---
Q
A
I
L
H
T
-
L
A
K
Q
N--------
K
S
G
V
T
Y
L
Y
A
C
N
S
A
K
E
H
-
T
F
A
Q
E
T
A
Q
L
I
A
Q
Q
G
--------
W
M
-
Q
Q
V
W
------------
Y
R
D
E
S
A
D
DVL------
Q
---------
G
E
M
Q
L
----------
A
--
E
L
I-
L
------------
P
------
I
---
E
D
G
D
F
Y
L
C
G
P
I
G
F
M
Q
Y
V
V
K
Q
L
L
-
A
L
G
V
D
K
------
A
-------
R
I
H
Y
E
V
F
G
-------
48
HHSearch
56.34
18%
28
- C3 -
-
2EIX
4
?
A:
[11-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
K
F
----
M
L
R
E
K
Q
I
I
N
H
N
T
R
L
F
R
F
N
L
H
H----
P
E-
D
V
------
V
G
L
P
I
G
Q
H
M
S
V
K
A
T
V
D
-----------------------------
G
K
E
-
I
Y
R
P
Y
T
P
V
S
---
S
D
DE
K
G
Y
F
D
L
I
I
K
V
Y
E---------
K
-----------------
G
Q
M
S
Q
Y
I
D
H
-
L
---------------
N
P
G
D
F
L
Q
V
R
-
G
P
K
G
Q
F
D
Y
K
P
N
M-
V
K
E
-
M
G
M
I
A
G
G
T
G
I
T
P
M
---
L
Q
V
A
R
A
-
I
I
K
N
PKE------
K
T
I
I
N
L
I
F
A
N
V
N
E
D
D
I
-
L
L
R
T
E
L
D
D
M
A
K
K
Y
S
--------
N
F
K
V
Y
Y
V
------------
L
N
N
P
PAGWTGG-----
V
---------
G
F
V
S
A
----------
D
--
M
I
K
-
Q
------------
H
FSPP--
S
---
S
D
I
K
V
M
M
C
G
P
P
M
M
N
K
A
M
Q
G
H
L
E
-
T
L
G
Y
T
P
------
E
-------
Q
W
F
------------
38
HHSearch
55.83
18%
-6
- C3 -
-
4K1X
1
?
B:
[3-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
----
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
-
T
R
-----
P
--
Q
T
------
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
----------------------------
G
K
P
-
I
M
R
A
Y
S
I
A
S
---
P
A
W-
D
E
E
L
E
F
Y
S
I
K
-----------
V
PD---------------
G
P
L
T
S
R
L
Q
H
-
I
---------------
K
V
G
E
Q
I
I
L
R
P
K
P
V
G
T
L
V
I
D
A
L
LP
G
K
R
-
L
W
F
L
A
T
G
T
G
I
A
P
F
---
A
S
L
M
R
E
-
P
E
A
Y
EK-------
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
-
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
LIGELVEG
K
L
K
Y
Y
P
T
------------
T
T
R
E
EFHH--------
M
---------
G
R
I
T
D
----------
N
--
L
A
S-
G
KVFEDLGIAPM-
N
------
P
---
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
G
L
R
E
------
G
ANSEPR-
E
F
V
V
E
K
Y
--------
41
HHSearch
55.65
18%
-7
- C3 -
-
2BGI
6
?
A:
[16-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
A
Q
----
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
-
T
R
-----
P
--
Q
T
------
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
----------------------------
G
K
P
-
I
M
R
A
Y
S
I
A
S
---
P
A
W-
D
E
E
L
E
F
Y
S
I
K
-----------
V
PD---------------
G
P
L
T
S
R
L
Q
H
-
I
---------------
K
V
G
E
Q
I
I
L
R
P
K
P
V
G
T
L
V
I
D
A
L
LP
G
K
R
-
L
W
F
L
A
T
G
T
G
I
A
P
F
---
A
S
L
M
R
E
-
P
E
A
Y
E
K
-------
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
-
E
Y
G
R
Q
L
V
E
A
L
Q
E
D
P
LIGELVEG
K
L
K
Y
Y
P
T
------------
T
T
R
E
EFH
H
--------
M
---------
G
R
I
T
D
----------
N
--
L
A
S
-
G
K
V
F
E
D
L
GIAPM-
N
------
P
---
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
G
L
R
E
G
A
NS
E
P
R
-------
E
F
V
V
E
K
A
--------
8
PsiBlast_PDB
54.51
23%
-26
- C3 -
-
2R6H
1
?
A:
[134-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
---------------
K
P
G
D
K
V
M
M
S
-
G
P
Y
G
D
F
H
I
Q
D
T
--
D
A
E
-
M
L
Y
I
G
G
G
A
G
M
A
P
L
R
A
Q
I
L
H
L
F
R
-
T
L
K
T
---------
G
R
K
V
S
Y
W
Y
G
A
R
S
K
N
E
I
-
F
Y
E
E
D
F
R
E
I
E
R
E
F
P
--------
N
F
K
F
H
I
A
------------
L
S
D
P
------------
Q
PEDNWT---
G
Y
V
G
F
I
H
Q
V
I
Y
D
NYL
K
--
D
H
--
D
------------
A
------
P
---
E
D
I
E
Y
Y
M
C
G
P
G
P
M
A
N
A
V
K
G
M
L
E
-
N
L
G
V
P
R
------
N
-------
M
L
F
F
D
D
F
--------
50
HHSearch
53.84
17%
-17
- C3 -
-
4FK8
1
?
B:
[19-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
T
A
----
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
-
T
R
-----
D
--
Q
A
------
L
R
F
N
N
G
E
F
T
M
V
G
L
E
V
D
-----------------------------
G
K
P
-
L
T
R
A
Y
S
I
V
S
---
P
N
Y-
E
E
H
L
E
F
F
S
I
K
V
Q---------
N
-----------------
G
P
L
T
S
R
L
Q
H
-
L
---------------
K
V
G
D
P
V
L
I
G
K
K
P
T
G
T
L
V
A
D
N
L
LP
G
K
T
-
L
W
M
L
S
T
G
T
G
L
A
P
F
---
M
S
I
I
R
D
-
P
D
I
Y
E
R
-------
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
-
A
Y
M
D
Y
I
K
H
D
L
P
G
H
E
YL
G
D
V
I
R
E
K
L
V
Y
Y
P
T
------------
V
--------------------------
R
I
T
D
----------
L
--
I
A
--
S
G
K
L
F
T
D
L
DMPPF
S
------
P
---
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
-
K
A
G
L
V
E
------
G
K
NSAPG-
H
Y
V
I
E
R
A
--------
37
HHSearch
53.09
18%
10
- C3 -
-
1TVC
1
MMOC_METCA
A:
[10-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
E
A
----
E
V
V
G
L
N
W
V
S
S
N
T
V
Q
F
L
L
Q
K
R
PDECG
N
--
R
G
------
V
K
F
E
P
G
Q
F
M
D
L
T
I
P
G
-------------------------------
T
D
-
V
S
R
S
Y
S
P
A
N
---
L
P
NP
E
G
R
L
E
F
L
I
R
V
-----------
L
PE---------------
G
R
F
S
D
Y
L
R
N
D
A
---------------
R
V
G
Q
V
L
S
V
K
-
G
P
L
G
V
F
G
L
K
E
R
G-
M
A
P
-
R
Y
F
V
A
G
G
T
G
L
A
P
V
---
V
S
M
V
R
Q
-
M
Q
E
W
TA-------
P
N
E
T
R
I
Y
F
G
V
N
T
E
P
E
L
-
F
Y
I
D
E
L
K
S
L
E
R
S
M
R
--------
N
L
T
V
K
A
C
------------
V
W
H
P
SGDWEGE-----
Q
---------
G
S
P
I
-----------
D
--
A
L
R
-
E
D
-----------
L
E
S
S---
D
---
A
N
P
D
I
Y
L
C
G
P
P
G
M
I
D
A
A
C
E
L
V
R
-
S
R
G
I
P
G
------
E
-------
Q
V
F
F
E
K
F
L
-------
32
HHSearch
52.38
16%
21
- C3 -
-
1QFJ
1
FRE_ECOLI
D:
[3-231]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
C
----
K
V
T
S
V
E
A
I
T
D
T
V
Y
R
V
R
I
V
P
D
--------
A
A
------
F
S
F
R
A
G
Q
Y
L
M
V
V
M
D
E
--------------------------------
R
-
D
K
R
P
F
S
M
A
S
---
T
P
DE
K
G
F
I
E
L
H
I
G
--------------------------------
Y
A
K
A
V
M
D
R
I
---------------
L
K
D
H
Q
I
V
V
D
-
I
P
H
G
E
A
W
L
R
D
D
E-
E
R
P
-
M
I
L
I
A
G
G
T
G
F
S
Y
A
---
R
S
I
L
L
T
-
A
L
A
R
NP-------
N
R
D
I
T
I
Y
W
G
G
R
E
E
Q
H
L
-
Y
D
L
C
E
L
E
A
L
S
L
K
H
P
--------
G
L
Q
V
V
P
V
------------
V
E
Q
P
------------
E
AGWRGRT--
G
T
V
L
T
----------
A
--
V
L
Q-
D
------------
H
GT----
L
---
A
E
H
D
I
Y
I
A
G
R
F
E
M
A
K
I
A
R
D
L
F
C
S
E
R
N
A
R
E
------
D
-------
R
L
F
G
D
A
F
A
F
------