@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0565: (2017-12-24 )
MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVYADETLITHTAEKPKEEKMIVEEKADKALETKNVVERTEQSEPSSTEAIASEKKEDEAVTPKEEKVSAKPEEKAPRIESQASSQEKPLKEDAKAVTNEEVNQMIENRKVDFNQNWYFKLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTFKLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLYKDGRENVIAVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVTSKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLWTVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLHHDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFDTWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNYSEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDRVGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAGIPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVELFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEIARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHGQGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLKSNQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPTTVPFVYSDGSRAERPVTWSLVDVSKPGIVTVKGMADGREVEARVEVIALKSELPVVKRIAPNTNLNSVDKSVSYVLTDGSVQEYEVDKWEIAEEDKAKLAIPGSRIQATGYLEGQPIHATLVVEEGNPAAPVVPTVTVGGEAVTGLTSRQPMQYRTLSYGAQLPEVTASAENADVTVLQASAANGMRASIFIQPKDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPADKVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKGQVELTIQANTEKKIAQSIRPVNVVTDLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQIFEVLGKVEGIDLEARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYAKEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVSNVNDKLISYNNQPANRWTNWNRSNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVGAPKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHFSFDKVETYAIRIRMVKADNKRGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPDLTDYYLESVDGKVPAVTANVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFTKDKNLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLTVEWEEVPAENLTKAGQFTVRGRVLGSNLVAEVTVRVTDKLGETLSDNPNYDENSNQAFASATNDIDKNSHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVAQAKLHFFADSGTDAPSKLVLERYVGPGFEVPTYYSNYQAYESGHPFNNPENWEAVPYRADKDIAAGDEINVTFKAVKAKVMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELADFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSLPVLVRLVSESGKQVKEYRIQLTKEKPVSAVQEDLPKLEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKVGKERIFTVINPDGSKEEKLREVVEVPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSEADQTNKAQLPNTGSAASQAAVAAGLALLGLSAGLVVTKGKKED
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160-.......--.170.......180.......190-.........-200.......210.......220.......230.......240.......250.......260.......270.......280-.-.-----.-----.---...290.......300.......310----........320..-.-....330.......340.......350.......--360..--.....370.......380...-.....390.......400.......410-........420.......430.......440.......450.......460.......470.-......480.......490.......500.......510..--...--..520....----...530...----....540.......550.......560-......-.570----------.....-....580.......590.......600.--...------...610.......----620....---.---..-----------630---------------.....---...640.......650.......660----------.....------------------------...--------------670.......680--------------------...------......690.--......700.......710.......720.-----.....------.730.......740.......750.......760....--...770.......780..-.-....790.......800..------.------....810.......820.-------....-..830---.........840--.......850....------.------..860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGKGHWN
R
K
R
V
Y
S
I
R
K
F
A
V
G
A
C
S
V
M
I
G
T
C
A
V
L
LGGNIAGE
S
V
V
YADE
T
L
ITHTAEKP
K
E
E
K
M
I
V
E
E
KADK
A
L
E
T
K
N
V
V
E
R
TEQSEPS
S
T
E
A
I
A
SEKKEDEAVTP
K
E
E
KVSAKPEEKAPRIESQASSQEK
P
L
K
E
D
A
K
A
V
T
N
E
E
V
N
Q
M
I
E
NRKVDFNQ
N
W
Y
F
K
--LNANSKE--AIKPDADV
S
T
W
K
KLDLPYDWSI---FNDFDHESP-AQNEGGQLNG
G
E
A
W
Y
R
K
TFKL
D
E
K
D
L
KKN
V
R
L
T
F
D
G
V
Y
MD
S
Q
V
Y
V
N
G
Q
L
V
GHYPNGYN
Q
F
S
Y
D
I
T
K
Y
L
Y
KDGRE
N
V
I
A
V
H
A
VN-K-Q-----P-----S---SRWYSGSG
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
VEK-----N
G
T
T
I
LTPKL
E
E
Q-Q-HGK
V
E
T
H
V
T
S
K
IVNTDDK
D
H
E
L
V
A
E
Y
Q
I
V
ERGG
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
KAHESTS
L
D
-
A
I
L
-
E
VERP
K
L
W
T
VLNDK
P
A
L
Y
E
L
I
T
R
V
YRD--G
Q
L
V
D
A
KKDLFG
Y
R
Y
Y
H
WTPNEGFSLNG
E
R
I
K
F
H
G
V
S
L
HHDHGALGAEEN
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
MGVNSIRTTHNPA
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
EAFDTWYGGK--KPY--DYG
R
F
FEKD----ATHPEARKG----EKWSD
F
D
L
R
T
M
V
E
RGKNN
P
A
I
F
M
W
SIG-NEIGEA-NG------------DA
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
DVDK
T
R
Y
V
T
MGAD
K
F
RF--GNG------SGG
H
E
K
I
A
D
E
L
D
A
----VGFNYSE---D---
N
Y
-----------
K
A
----------------
L
RAKH---P
K
W
L
I
YGSETSSATRTRGSYYR
P
E
R
-----------ELKHS------------------------NGP--------------ERNYEQSDYGN----------------------DRV------GWGKT
A
T
A
S
W
--
T
FDRDNAGYA
G
Q
F
I
WTGTDYIGEPTPWHNQ-----NQTPV------KSS
Y
F
G
I
V
DTAGIPKH
D
F
Y
L
Y
QSQWVSVKKK
P
M
V
H
LLP--HWNWE
N
K
E
L
A
S
K
VADSEG-
K
-
I
P
V
R
A
YSNA
S
S
V
E
L
F
LNGK------S------LG
L
K
TFNKKQTSDGRTYQ-------EGAN-A
N
E
-----
L
Y
L
E
W
K
V
A
YQPG--
T
L
E
A
I
ARDESG
K
E
I
------
A
------
R
DKITTAGK
P
A
A
V
R
L
I
KED
H
A
IAADGK
D
L
T
Y
I
Y
Y
E
I
VDSQG
N
V
V
PTAN
N
L
V
R
F
Q
L
HGQ
G
Q
L
V
G
VDNG
E
Q
A
S
R
E
R
Y
KAQAD
G
S
W
I
R
K
AFNGK
G
V
A
I
V
KSTEQA
G
K
F
T
L
T
A
H
S
D
L
LKSN
Q
V
T
V
F
TGKKEGQEKTVLGTEVP
K
V
Q
T
I
IGEAPEMPTT
V
P
F
V
YSDGSRAER
P
V
T
W
S
L
V
DVSKP
G
I
V
T
V
K
GMADG
R
E
V
E
A
R
V
E
V
I
A
LKSELP
V
V
K
RIAPNTNLNSVDK
S
V
S
Y
V
LTDGSV
Q
E
Y
EVDKWEIAEEDK
A
K
L
AIPGS
R
I
Q
A
T
GYLEGQ
P
I
H
A
T
L
V
V
EEGNPAA
P
V
V
P
T
V
T
VGGEAVTGLTSRQP
M
Q
Y
R
TLSYGAQLPEVTASAENA
D
V
T
V
L
Q
ASAANG
M
R
A
S
I
F
I
QPKDGG
P
L
Q
T
Y
A
I
Q
F
L
E
EAP
K
I
A
H
L
S
L
Q
V
EKADSLKED
Q
T
V
K
L
S
V
R
A
HYQDG
T
Q
AVLPA
D
K
V
T
FSTSGE
G
E
V
A
I
R
K
G
M
L
E
LHKP
G
A
V
T
L
N
A
EYEGAK
G
Q
V
E
L
T
I
QAN
T
E
K
K
I
A
Q
SIRP
V
N
V
V
T
D
LHQEPSL
P
A
T
V
T
V
E
YDKGFPKT
H
K
V
T
W
QAI
P
K
E
KL
D
S
Y
Q
I
F
E
V
L
GKVEGI
D
L
E
A
R
A
K
V
S
V
E
G
I
V
S
V
E
E
V
S
VTTPIAEAPQL
P
E
S
V
R
TYDSNGHVSS
A
K
V
A
W
DAI
R
P
E
Q
Y
AKE
G
V
F
T
VN
G
R
LEG
T
Q
L
T
T
K
L
H
V
R
V
S
AQTEQGANISDQWTGSEL
P
L
A
FASDSNPSDPVSNVND
K
L
ISYNNQPANRWTNWNRSNPEA
S
V
G
V
L
FGDSGILSKRSVDNL
S
V
GFHEDHGVGAPK
S
Y
V
I
E
Y
YVGKTVPTAPKNPSFVGNEDHVFNDSAN
W
K
PVTNLKAP
A
Q
LKAGEMNHFSFDK
V
E
T
Y
A
I
R
I
R
M
V
KADNKRGTS
I
T
E
V
Q
I
F
A
K
Q
V
A
A
AKQG
Q
T
R
I
Q
VD
G
K
D
LANFNP
D
L
T
D
Y
Y
L
E
SVDGKV
P
A
V
T
A
NVSNNG
L
A
T
VVPSVREGE
P
V
R
V
I
A
KAENG
D
I
L
G
E
Y
R
L
H
FTKDKNLLSHK
P
V
A
A
V
K
Q
A
R
L
L
Q
V
G
Q
ALELPTKV
P
V
Y
F
TGKDGYETK
D
L
T
V
E
WEEV
P
A
E
NLTKAG
Q
F
T
V
R
G
R
V
LGSN
L
V
A
E
V
T
V
R
V
T
D
KL
G
E
T
LSDNPNYDENSNQ
A
F
A
SATNDIDKNSHDRVDYLNDGDHSENRRWTNWSPTPSSNPEV
S
A
G
V
I
FRENG
K
I
V
E
R
T
V
A
Q
A
K
L
H
F
F
ADSGTD
A
P
S
K
L
V
L
E
R
YVGPGFEVP
T
Y
YSN
Y
Q
AYESGHPFNNPENWEAVPYRADKDIAAGD
E
I
N
V
T
F
K
A
V
K
A
K
V
M
R
W
R
M
E
RKADKS
G
V
A
M
I
E
M
T
F
LA
P
S
ELPQESTQ
S
K
I
L
V
D
G
K
E
L
A
D
F
A
ENRQ
D
Y
Q
I
T
YKGQRP
K
V
S
VEENN
Q
V
A
S
T
V
VDSGE
D
S
L
P
V
L
V
R
L
V
S
ESG
K
Q
V
K
E
Y
R
I
Q
LTKEK
P
V
S
A
V
Q
E
DL
P
K
L
E
F
V
E
K
D
L
A
Y
K
TVEKKD
S
T
L
Y
LGETR
V
E
QEGKVGK
E
R
I
F
T
V
INPDG
S
K
E
E
K
L
R
E
V
V
EVPTD
R
I
V
L
V
GTKP
V
A
Q
EAKKPQVSEKADTKPIDSSEADQTNKAQLPNTGS
A
A
S
Q
A
A
V
A
A
G
L
A
L
L
GLSA
G
L
V
V
TKGKKED
2
PsiBlast_PDB
89.38
99%
-15
- C1 -
-
4CU7
18
?
A:
[1-848]
----------------------------------------------------------------------------------------------------------------------------------------
A
V
T
N
E
E
V
N
Q
M
I
E
D
R
K
V
D
F
N
Q
N
W
Y
F
K
--
L
N
A
N
S
K
E
--
A
I
K
P
D
A
D
V
S
T
W
K
K
L
D
L
P
Y
D
W
S
I
---
F
N
D
F
D
H
E
S
P
-
A
Q
N
E
G
G
Q
L
N
G
G
E
A
W
Y
R
K
T
F
K
L
D
E
K
D
L
K
K
N
V
R
L
T
F
D
G
V
Y
M
D
S
Q
V
Y
V
N
G
Q
L
V
G
H
Y
P
N
G
Y
N
Q
F
S
Y
D
I
T
K
Y
L
Q
K
D
G
R
E
N
V
I
A
V
H
A
V
N
-
K
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
V
E
K
-----
N
G
T
T
I
L
T
P
K
L
E
E
Q
-
Q
-
H
G
K
V
E
T
H
V
T
S
K
I
V
N
T
D
D
K
D
H
E
L
V
A
E
Y
Q
I
V
E
R
G
G
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
K
A
H
E
S
T
S
L
D
-
A
I
L
-
E
V
E
R
P
K
L
W
T
V
L
N
D
K
P
A
L
Y
E
L
I
T
R
V
Y
R
D
--
G
Q
L
V
D
A
K
K
D
L
F
G
Y
R
Y
Y
H
W
T
P
N
E
G
F
S
L
N
G
E
R
I
K
F
H
G
V
S
L
H
H
D
H
G
A
L
G
A
E
E
N
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
M
G
V
N
S
I
R
T
T
H
N
P
A
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
E
A
F
D
T
W
Y
G
G
K
--
K
P
Y
--
D
Y
G
R
F
F
E
K
D
----
A
T
H
P
E
A
R
K
G
----
E
K
W
S
D
F
D
L
R
T
M
V
E
R
G
K
N
N
P
A
I
F
M
W
S
I
G
-
N
E
I
G
E
A
-
N
G
------------
D
A
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
D
V
D
K
T
R
Y
V
T
M
G
A
D
K
F
R
F
--
G
N
G
------
S
G
G
H
E
K
I
A
D
E
L
D
A
----
V
G
F
N
Y
S
E
---
D
---
N
Y
-----------
K
A
----------------
L
R
A
K
H
---
P
K
W
L
I
Y
G
S
E
T
S
S
A
T
R
T
R
G
S
Y
Y
R
P
E
R
-----------
E
L
K
H
S
------------------------
N
G
P
--------------
E
R
N
Y
E
Q
S
D
Y
G
N
----------------------
D
R
V
------
G
W
G
K
T
A
T
A
S
W
--
T
F
D
R
D
N
A
G
Y
A
G
Q
F
I
W
T
G
T
D
Y
I
G
E
P
T
P
W
H
N
Q
-----
N
Q
T
P
V
------
K
S
S
Y
F
G
I
V
D
T
A
G
I
P
K
H
D
F
Y
L
Y
Q
S
Q
W
V
S
V
K
K
K
P
M
V
H
L
L
P
--
H
W
N
W
E
N
K
E
L
A
S
K
V
A
D
S
E
G
-
K
-
I
P
V
R
A
Y
S
N
A
S
S
V
E
L
F
L
N
G
K
------
S
------
L
G
L
K
T
F
N
K
K
Q
T
S
D
G
R
T
Y
Q
-------
E
G
A
N
-
A
N
E
-----
L
Y
L
E
W
K
V
A
Y
Q
P
G
--
T
L
E
A
I
A
R
D
E
S
G
K
E
I
------
A
------
R
D
K
I
T
T
A
G
K
P
A
A
V
R
L
I
K
E
D
H
A
I
A
A
D
G
K
D
L
T
Y
I
Y
Y
E
I
V
D
S
Q
G
N
V
V
P
T
A
N
N
L
V
R
F
Q
L
H
G
Q
G
Q
L
V
G
V
D
N
G
E
Q
A
S
R
E
R
Y
K
A
Q
A
D
G
S
W
I
R
K
A
F
N
G
K
G
V
A
I
V
K
S
T
E
Q
A
G
K
F
T
L
T
A
H
S
D
L
L
K
S
N
Q
V
T
V
F
T
G
K
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.95
99%
-17
- C1 -
-
4CUC
6
?
A:
[1-847]
----------------------------------------------------------------------------------------------------------------------------------------
A
V
T
N
E
E
V
N
Q
M
I
E
D
R
K
V
D
F
N
Q
N
W
Y
F
K
--
L
N
A
N
S
K
E
--
A
I
K
P
D
A
D
V
S
T
W
K
K
L
D
L
P
Y
D
W
S
I
---
F
N
D
F
D
H
E
S
P
-
A
Q
N
E
G
G
Q
L
N
G
G
E
A
W
Y
R
K
T
F
K
L
D
E
K
D
L
K
K
N
V
R
L
T
F
D
G
V
Y
M
D
S
Q
V
Y
V
N
G
Q
L
V
G
H
Y
P
N
G
Y
N
Q
F
S
Y
D
I
T
K
Y
L
Q
K
D
G
R
E
N
V
I
A
V
H
A
V
N
-
K
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
V
E
K
-----
N
G
T
T
I
L
T
P
K
L
E
E
Q
-
Q
-
H
G
K
V
E
T
H
V
T
S
K
I
V
N
T
D
D
K
D
H
E
L
V
A
E
Y
Q
I
V
E
R
G
G
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
K
A
H
E
S
T
S
L
D
-
A
I
L
-
E
V
E
R
P
K
L
W
T
V
L
N
D
K
P
A
L
Y
E
L
I
T
R
V
Y
R
D
--
G
Q
L
V
D
A
K
K
D
L
F
G
Y
R
Y
Y
H
W
T
P
N
E
G
F
S
L
N
G
E
R
I
K
F
H
G
V
S
L
H
H
D
H
G
A
L
G
A
E
E
N
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
M
G
V
N
S
I
R
T
T
H
N
P
A
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
E
A
F
D
T
W
Y
G
G
K
--
K
P
Y
--
D
Y
G
R
F
F
E
K
D
----
A
T
H
P
E
A
R
K
G
----
E
K
W
S
D
F
D
L
R
T
M
V
E
R
G
K
N
N
P
A
I
F
M
W
S
I
G
-
N
E
I
G
E
A
-
N
G
------------
D
A
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
D
V
D
K
T
R
Y
V
T
M
G
A
D
K
F
R
F
--
G
N
G
------
S
G
G
H
E
K
I
A
D
E
L
D
A
----
V
G
F
N
Y
S
E
---
D
---
N
Y
-----------
K
A
----------------
L
R
A
K
H
---
P
K
W
L
I
Y
G
S
Q
T
S
S
A
T
R
T
R
G
S
Y
Y
R
P
E
R
-----------
E
L
K
H
S
------------------------
N
G
P
--------------
E
R
N
Y
E
Q
S
D
Y
G
N
----------------------
D
R
V
------
G
W
G
K
T
A
T
A
S
W
--
T
F
D
R
D
N
A
G
Y
A
G
Q
F
I
W
T
G
T
D
Y
I
G
E
P
T
P
W
H
N
Q
-----
N
Q
T
P
V
------
K
S
S
Y
F
G
I
V
D
T
A
G
I
P
K
H
D
F
Y
L
Y
Q
S
Q
W
V
S
V
K
K
K
P
M
V
H
L
L
P
--
H
W
N
W
E
N
K
E
L
A
S
K
V
A
D
S
E
G
-
K
-
I
P
V
R
A
Y
S
N
A
S
S
V
E
L
F
L
N
G
K
------
S
------
L
G
L
K
T
F
N
K
K
Q
T
S
D
G
R
T
Y
Q
-------
E
G
A
N
-
A
N
E
-----
L
Y
L
E
W
K
V
A
Y
Q
P
G
--
T
L
E
A
I
A
R
D
E
S
G
K
E
I
------
A
------
R
D
K
I
T
T
A
G
K
P
A
A
V
R
L
I
K
E
D
H
A
I
A
A
D
G
K
D
L
T
Y
I
Y
Y
E
I
V
D
S
Q
G
N
V
V
P
T
A
N
N
L
V
R
F
Q
L
H
G
Q
G
Q
L
V
G
V
D
N
G
E
Q
A
S
R
E
R
Y
K
A
Q
A
D
G
S
W
I
R
K
A
F
N
G
K
G
V
A
I
V
K
S
T
E
Q
A
G
K
F
T
L
T
A
H
S
D
L
L
K
S
N
Q
V
T
V
F
T
G
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
88.94
100%
-17
- C1 -
-
4CUC
6
?
A:
[3-846]
------------------------------------------------------------------------------------------------------------------------------------------
T
N
E
E
V
N
Q
M
I
E
D
R
K
V
D
F
N
Q
N
W
Y
F
K
--
L
N
A
N
S
K
E
--
A
I
K
P
D
A
D
V
S
T
W
K
K
L
D
L
P
Y
D
W
S
I
---
F
N
D
F
D
H
E
S
P
-
A
Q
N
E
G
G
Q
L
N
G
G
E
A
W
Y
R
K
T
F
K
L
D
E
K
D
L
K
K
N
V
R
L
T
F
D
G
V
Y
M
D
S
Q
V
Y
V
N
G
Q
L
V
G
H
Y
P
N
G
Y
N
Q
F
S
Y
D
I
T
K
Y
L
Q
K
D
G
R
E
N
V
I
A
V
H
A
V
N
-
K
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
V
E
K
-----
N
G
T
T
I
L
T
P
K
L
E
E
Q
-
Q
-
H
G
K
V
E
T
H
V
T
S
K
I
V
N
T
D
D
K
D
H
E
L
V
A
E
Y
Q
I
V
E
R
G
G
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
K
A
H
E
S
T
S
L
D
-
A
I
L
-
E
V
E
R
P
K
L
W
T
V
L
N
D
K
P
A
L
Y
E
L
I
T
R
V
Y
R
D
--
G
Q
L
V
D
A
K
K
D
L
F
G
Y
R
Y
Y
H
W
T
P
N
E
G
F
S
L
N
G
E
R
I
K
F
H
G
V
S
L
H
H
D
H
G
A
L
G
A
E
E
N
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
M
G
V
N
S
I
R
T
T
H
N
P
A
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
E
A
F
D
T
W
Y
G
G
K
--
K
P
Y
--
D
Y
G
R
F
F
E
K
D
----
A
T
H
P
E
A
R
K
G
----
E
K
W
S
D
F
D
L
R
T
M
V
E
R
G
K
N
N
P
A
I
F
M
W
S
I
G
-
N
E
I
G
E
A
-
N
G
------------
D
A
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
D
V
D
K
T
R
Y
V
T
M
G
A
D
K
F
R
F
--
G
N
G
------
S
G
G
H
E
K
I
A
D
E
L
D
A
----
V
G
F
N
Y
S
E
---
D
---
N
Y
-----------
K
A
----------------
L
R
A
K
H
---
P
K
W
L
I
Y
G
S
Q
T
S
S
A
T
R
T
R
G
S
Y
Y
R
P
E
R
-----------
E
L
K
H
S
------------------------
N
G
P
--------------
E
R
N
Y
E
Q
S
D
Y
G
N
----------------------
D
R
V
------
G
W
G
K
T
A
T
A
S
W
--
T
F
D
R
D
N
A
G
Y
A
G
Q
F
I
W
T
G
T
D
Y
I
G
E
P
T
P
W
H
N
Q
-----
N
Q
T
P
V
------
K
S
S
Y
F
G
I
V
D
T
A
G
I
P
K
H
D
F
Y
L
Y
Q
S
Q
W
V
S
V
K
K
K
P
M
V
H
L
L
P
--
H
W
N
W
E
N
K
E
L
A
S
K
V
A
D
S
E
G
-
K
-
I
P
V
R
A
Y
S
N
A
S
S
V
E
L
F
L
N
G
K
------
S
------
L
G
L
K
T
F
N
K
K
Q
T
S
D
G
R
T
Y
Q
-------
E
G
A
N
-
A
N
E
-----
L
Y
L
E
W
K
V
A
Y
Q
P
G
--
T
L
E
A
I
A
R
D
E
S
G
K
E
I
------
A
------
R
D
K
I
T
T
A
G
K
P
A
A
V
R
L
I
K
E
D
H
A
I
A
A
D
G
K
D
L
T
Y
I
Y
Y
E
I
V
D
S
Q
G
N
V
V
P
T
A
N
N
L
V
R
F
Q
L
H
G
Q
G
Q
L
V
G
V
D
N
G
E
Q
A
S
R
E
R
Y
K
A
Q
A
D
G
S
W
I
R
K
A
F
N
G
K
G
V
A
I
V
K
S
T
E
Q
A
G
K
F
T
L
T
A
H
S
D
L
L
K
S
N
Q
V
T
V
F
T
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.76
99%
-16
- C1 -
-
4CU6
25
?
A:
[2-848]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
E
E
V
N
Q
M
I
E
D
R
K
V
D
F
N
Q
N
W
Y
F
K
--
L
N
A
N
S
K
E
--
A
I
K
P
D
A
D
V
S
T
W
K
K
L
D
L
P
Y
D
W
S
I
---
F
N
D
F
D
H
E
S
P
-
A
Q
N
E
G
G
Q
L
N
G
G
E
A
W
Y
R
K
T
F
K
L
D
E
K
D
L
K
K
N
V
R
L
T
F
D
G
V
Y
M
D
S
Q
V
Y
V
N
G
Q
L
V
G
H
Y
P
N
G
Y
N
Q
F
S
Y
D
I
T
K
Y
L
Q
K
D
G
R
E
N
V
I
A
V
H
A
V
N
-
K
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
V
E
K
-----
N
G
T
T
I
L
T
P
K
L
E
E
Q
-
Q
-
H
G
K
V
E
T
H
V
T
S
K
I
V
N
T
D
D
K
D
H
E
L
V
A
E
Y
Q
I
V
E
R
G
G
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
K
A
H
E
S
T
S
L
D
-
A
I
L
-
E
V
E
R
P
K
L
W
T
V
L
N
D
K
P
A
L
Y
E
L
I
T
R
V
Y
R
D
--
G
Q
L
V
D
A
K
K
D
L
F
G
Y
R
Y
Y
H
W
T
P
N
E
G
F
S
L
N
G
E
R
I
K
F
H
G
V
S
L
H
H
D
H
G
A
L
G
A
E
E
N
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
M
G
V
N
S
I
R
T
T
H
N
P
A
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
E
A
F
D
T
W
Y
G
G
K
--
K
P
Y
--
D
Y
G
R
F
F
E
K
D
----
A
T
H
P
E
A
R
K
G
----
E
K
W
S
D
F
D
L
R
T
M
V
E
R
G
K
N
N
P
A
I
F
M
W
S
I
G
-
N
E
I
G
E
A
-
N
G
------------
D
A
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
D
V
D
K
T
R
Y
V
T
M
G
A
D
K
F
R
F
--
G
N
G
------
S
G
G
H
E
K
I
A
D
E
L
D
A
----
V
G
F
N
Y
S
E
---
D
---
N
Y
-----------
K
A
----------------
L
R
A
K
H
---
P
K
W
L
I
Y
G
S
E
T
S
S
A
T
R
T
R
G
S
Y
Y
R
P
E
R
-----------
E
L
K
H
S
------------------------
N
G
P
--------------
E
R
N
Y
E
Q
S
D
Y
G
N
----------------------
D
R
V
------
G
W
G
K
T
A
T
A
S
W
--
T
F
D
R
D
N
A
G
Y
A
G
Q
F
I
W
T
G
T
D
Y
I
G
E
P
T
P
W
H
N
Q
-----
N
Q
T
P
V
------
K
S
S
Y
F
G
I
V
D
T
A
G
I
P
K
H
D
F
Y
L
Y
Q
S
Q
W
V
S
V
K
K
K
P
M
V
H
L
L
P
--
H
W
N
W
E
N
K
E
L
A
S
K
V
A
D
S
E
G
-
K
-
I
P
V
R
A
Y
S
N
A
S
S
V
E
L
F
L
N
G
K
------
S
------
L
G
L
K
T
F
N
K
K
Q
T
S
D
G
R
T
Y
Q
-------
E
G
A
N
-
A
N
E
-----
L
Y
L
E
W
K
V
A
Y
Q
P
G
--
T
L
E
A
I
A
R
D
E
S
G
K
E
I
------
A
------
R
D
K
I
T
T
A
G
K
P
A
A
V
R
L
I
K
E
D
H
A
I
A
A
D
G
K
D
L
T
Y
I
Y
Y
E
I
V
D
S
Q
G
N
V
V
P
T
A
N
N
L
V
R
F
Q
L
H
G
Q
G
Q
L
V
G
V
D
N
G
E
Q
A
S
R
E
R
Y
K
A
Q
A
D
G
S
W
I
R
K
A
F
N
G
K
G
V
A
I
V
K
S
T
E
Q
A
G
K
F
T
L
T
A
H
S
D
L
L
K
S
N
Q
V
T
V
F
T
G
K
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.59
99%
-14
- C1 -
-
4CU8
25
?
A:
[1-848]
----------------------------------------------------------------------------------------------------------------------------------------
A
V
T
N
E
E
V
N
Q
M
I
E
D
R
K
V
D
F
N
Q
N
W
Y
F
K
--
L
N
A
N
S
K
E
--
A
I
K
P
D
A
D
V
S
T
W
K
K
L
D
L
P
Y
D
W
S
I
---
F
N
D
F
D
H
E
S
P
-
A
Q
N
E
G
G
Q
L
N
G
G
E
A
W
Y
R
K
T
F
K
L
D
E
K
D
L
K
K
N
V
R
L
T
F
D
G
V
Y
M
D
S
Q
V
Y
V
N
G
Q
L
V
G
H
Y
P
N
G
Y
N
Q
F
S
Y
D
I
T
K
Y
L
Q
K
D
G
R
E
N
V
I
A
V
H
A
V
N
-
K
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
V
E
K
-----
N
G
T
T
I
L
T
P
K
L
E
E
Q
-
Q
-
H
G
K
V
E
T
H
V
T
S
K
I
V
N
T
D
D
K
D
H
E
L
V
A
E
Y
Q
I
V
E
R
G
G
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
K
A
H
E
S
T
S
L
D
-
A
I
L
-
E
V
E
R
P
K
L
W
T
V
L
N
D
K
P
A
L
Y
E
L
I
T
R
V
Y
R
D
--
G
Q
L
V
D
A
K
K
D
L
F
G
Y
R
Y
Y
H
W
T
P
N
E
G
F
S
L
N
G
E
R
I
K
F
H
G
V
S
L
H
H
D
H
G
A
L
G
A
E
E
N
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
M
G
V
N
S
I
R
T
T
H
N
P
A
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
E
A
F
D
T
W
Y
G
G
K
--
K
P
Y
--
D
Y
G
R
F
F
E
K
D
----
A
T
H
P
E
A
R
K
G
----
E
K
W
S
D
F
D
L
R
T
M
V
E
R
G
K
N
N
P
A
I
F
M
W
S
I
G
-
N
E
I
G
E
A
-
N
G
------------
D
A
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
D
V
D
K
T
R
Y
V
T
M
G
A
D
K
F
R
F
--
G
N
G
------
S
G
G
H
E
K
I
A
D
E
L
D
A
----
V
G
F
N
Y
S
E
---
D
---
N
Y
-----------
K
A
----------------
L
R
A
K
H
---
P
K
W
L
I
Y
G
S
E
T
S
S
A
T
R
T
R
G
S
Y
Y
R
P
E
R
-----------
E
L
K
H
S
------------------------
N
G
P
--------------
E
R
N
Y
E
Q
S
D
Y
G
N
----------------------
D
R
V
------
G
W
G
K
T
A
T
A
S
W
--
T
F
D
R
D
N
A
G
Y
A
G
Q
F
I
W
T
G
T
D
Y
I
G
E
P
T
P
W
H
N
Q
-----
N
Q
T
P
V
------
K
S
S
Y
F
G
I
V
D
T
A
G
I
P
K
H
D
F
Y
L
Y
Q
S
Q
W
V
S
V
K
K
K
P
M
V
H
L
L
P
--
H
W
N
W
E
N
K
E
L
A
S
K
V
A
D
S
E
G
-
K
-
I
P
V
R
A
Y
S
N
A
S
S
V
E
L
F
L
N
G
K
------
S
------
L
G
L
K
T
F
N
K
K
Q
T
S
D
G
R
T
Y
Q
-------
E
G
A
N
-
A
N
E
-----
L
Y
L
E
W
K
V
A
Y
Q
P
G
--
T
L
E
A
I
A
R
D
E
S
G
K
E
I
------
A
------
R
D
K
I
T
T
A
G
K
P
A
A
V
R
L
I
K
E
D
H
A
I
A
A
D
G
K
D
L
T
Y
I
Y
Y
E
I
V
D
S
Q
G
N
V
V
P
T
A
N
N
L
V
R
F
Q
L
H
G
Q
G
Q
L
V
G
V
D
N
G
E
Q
A
S
R
E
R
Y
K
A
Q
A
D
G
S
W
I
R
K
A
F
N
G
K
G
V
A
I
V
K
S
T
E
Q
A
G
K
F
T
L
T
A
H
S
D
L
L
K
S
N
Q
V
T
V
F
T
G
K
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
87.51
100%
-15
- C1 -
-
4CU8
25
?
A:
[3-846]
------------------------------------------------------------------------------------------------------------------------------------------
T
N
E
E
V
N
Q
M
I
E
D
R
K
V
D
F
N
Q
N
W
Y
F
K
--
L
N
A
N
S
K
E
--
A
I
K
P
D
A
D
V
S
T
W
K
K
L
D
L
P
Y
D
W
S
I
---
F
N
D
F
D
H
E
S
P
-
A
Q
N
E
G
G
Q
L
N
G
G
E
A
W
Y
R
K
T
F
K
L
D
E
K
D
L
K
K
N
V
R
L
T
F
D
G
V
Y
M
D
S
Q
V
Y
V
N
G
Q
L
V
G
H
Y
P
N
G
Y
N
Q
F
S
Y
D
I
T
K
Y
L
Q
K
D
G
R
E
N
V
I
A
V
H
A
V
N
-
K
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
Q
V
T
D
K
V
H
V
E
K
-----
N
G
T
T
I
L
T
P
K
L
E
E
Q
-
Q
-
H
G
K
V
E
T
H
V
T
S
K
I
V
N
T
D
D
K
D
H
E
L
V
A
E
Y
Q
I
V
E
R
G
G
H
--
A
V
T
G
L
--
V
R
T
A
S
R
T
L
K
A
H
E
S
T
S
L
D
-
A
I
L
-
E
V
E
R
P
K
L
W
T
V
L
N
D
K
P
A
L
Y
E
L
I
T
R
V
Y
R
D
--
G
Q
L
V
D
A
K
K
D
L
F
G
Y
R
Y
Y
H
W
T
P
N
E
G
F
S
L
N
G
E
R
I
K
F
H
G
V
S
L
H
H
D
H
G
A
L
G
A
E
E
N
Y
K
A
E
Y
R
R
L
K
Q
M
K
-
E
M
G
V
N
S
I
R
T
T
H
N
P
A
S
E
Q
T
L
Q
I
A
A
E
L
G
L
L
V
Q
E
E
A
F
D
T
W
Y
G
G
K
--
K
P
Y
--
D
Y
G
R
F
F
E
K
D
----
A
T
H
P
E
A
R
K
G
----
E
K
W
S
D
F
D
L
R
T
M
V
E
R
G
K
N
N
P
A
I
F
M
W
S
I
G
-
N
E
I
G
E
A
-
N
G
------------
D
A
H
S
L
-
A
T
V
K
R
L
V
K
V
I
K
D
V
D
K
T
R
Y
V
T
M
G
A
D
K
F
R
F
--
G
N
G
------
S
G
G
H
E
K
I
A
D
E
L
D
A
----
V
G
F
N
Y
S
E
---
D
---
N
Y
-----------
K
A
----------------
L
R
A
K
H
---
P
K
W
L
I
Y
G
S
E
T
S
S
A
T
R
T
R
G
S
Y
Y
R
P
E
R
-----------
E
L
K
H
S
------------------------
N
G
P
--------------
E
R
N
Y
E
Q
S
D
Y
G
N
----------------------
D
R
V
------
G
W
G
K
T
A
T
A
S
W
--
T
F
D
R
D
N
A
G
Y
A
G
Q
F
I
W
T
G
T
D
Y
I
G
E
P
T
P
W
H
N
Q
-----
N
Q
T
P
V
------
K
S
S
Y
F
G
I
V
D
T
A
G
I
P
K
H
D
F
Y
L
Y
Q
S
Q
W
V
S
V
K
K
K
P
M
V
H
L
L
P
--
H
W
N
W
E
N
K
E
L
A
S
K
V
A
D
S
E
G
-
K
-
I
P
V
R
A
Y
S
N
A
S
S
V
E
L
F
L
N
G
K
------
S
------
L
G
L
K
T
F
N
K
K
Q
T
S
D
G
R
T
Y
Q
-------
E
G
A
N
-
A
N
E
-----
L
Y
L
E
W
K
V
A
Y
Q
P
G
--
T
L
E
A
I
A
R
D
E
S
G
K
E
I
------
A
------
R
D
K
I
T
T
A
G
K
P
A
A
V
R
L
I
K
E
D
H
A
I
A
A
D
G
K
D
L
T
Y
I
Y
Y
E
I
V
D
S
Q
G
N
V
V
P
T
A
N
N
L
V
R
F
Q
L
H
G
Q
G
Q
L
V
G
V
D
N
G
E
Q
A
S
R
E
R
Y
K
A
Q
A
D
G
S
W
I
R
K
A
F
N
G
K
G
V
A
I
V
K
S
T
E
Q
A
G
K
F
T
L
T
A
H
S
D
L
L
K
S
N
Q
V
T
V
F
T
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.61
40%
38
- C1 -
-
5DMY
2
?
A:
[35-886]
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
R
T
S
D
F
D
A
N
W
K
F
M
--
L
-
S
D
S
V
Q
--
A
Q
D
P
A
F
D
D
S
A
W
Q
Q
V
D
L
P
H
D
Y
S
I
---
T
Q
K
Y
S
Q
S
N
E
-
A
--
E
S
A
Y
L
P
G
G
T
G
W
Y
R
K
S
F
T
I
D
R
D
L
A
G
K
R
I
A
I
N
F
D
G
V
Y
M
N
A
T
V
W
F
N
G
V
K
L
G
T
H
P
Y
G
Y
S
P
F
S
F
D
L
T
G
N
A
-
K
F
G
G
E
N
T
I
V
V
K
V
E
N
-
R
-
L
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
T
V
T
D
G
V
H
V
G
N
-----
N
G
V
A
I
K
T
P
S
L
A
T
Q
-
N
-
G
G
N
V
T
M
N
L
T
T
K
V
A
N
D
T
E
A
A
A
N
I
T
L
K
Q
T
V
F
P
K
G
G
K
TD
A
A
I
G
T
--
V
T
T
A
S
K
S
I
A
A
G
A
S
A
D
V
T
-
S
T
I
-
T
A
A
S
P
K
L
W
S
I
K
N
--
P
N
L
Y
T
V
R
T
E
V
L
N
G
--
D
T
V
L
D
T
Y
D
T
E
Y
G
F
R
W
T
G
F
D
A
T
S
G
F
S
L
N
G
E
K
V
K
L
K
G
V
S
M
H
H
D
Q
G
S
L
G
A
V
A
N
R
R
A
I
E
R
Q
V
E
I
L
Q
-
K
M
G
V
N
S
I
R
T
T
H
N
P
A
A
K
A
L
I
D
V
C
N
E
K
G
V
L
V
V
E
E
V
F
D
M
W
N
R
S
K
NG
N
T
E
--
D
Y
G
K
W
F
G
Q
T
----
I
A
G
D
N
A
V
L
G
GDKD
E
T
W
A
K
F
D
L
T
S
T
I
N
R
D
R
N
A
P
S
V
I
M
W
S
L
G
-
N
E
M
M
E
G
I
S
G
------------
S
V
S
D
F
P
A
T
S
A
K
L
V
A
W
T
K
A
A
D
S
T
R
P
M
T
Y
G
D
N
K
I
K
A
--
N
W
N
------
E
--
S
N
T
M
G
D
N
L
T
A
N
G
G
V
V
G
T
N
Y
S
D
---
G
A
--
N
Y
-----------
D
K
----------------
I
R
T
T
H
---
P
S
W
A
I
Y
G
S
E
T
A
S
A
I
N
S
R
G
I
Y
N
R
T
T
G
---------------
S
------------------------
D
K
-------------------
Q
L
T
S
Y
D
N
----------------------
S
A
V
------
G
W
G
A
V
A
S
S
A
W
Y
D
V
V
Q
R
D
F
V
--
A
G
T
Y
V
W
T
G
F
D
Y
L
G
E
P
T
P
W
N
G
T
-----
G
S
G
A
V
G
SWPSP
K
N
S
Y
F
G
I
V
D
T
A
G
F
P
K
D
T
Y
Y
F
Y
Q
S
Q
W
--
N
D
D
V
H
T
L
H
I
L
P
--
A
W
N
-
E
N
-----
V
V
A
K
G
S
G
N
K
-
V
P
V
V
V
Y
T
D
A
A
K
V
K
L
Y
F
T
P
K
------
G
ST
E
K
R
L
I
G
E
K
S
F
T
K
K
T
T
A
A
G
Y
T
Y
Q
V
Y
-----
E
G
T
D
-
K
D
S
TAHKN
M
Y
L
T
W
N
V
P
W
A
E
G
--
T
I
S
A
E
A
Y
D
E
N
N
R
L
I
PEGS
T
E
G
------
N
A
S
V
T
T
T
G
K
A
A
K
L
K
A
D
A
D
R
K
T
I
T
A
D
G
K
D
L
S
Y
I
E
V
D
V
T
D
A
N
G
H
I
V
P
D
A
A
N
R
V
T
F
D
V
K
G
A
G
K
L
V
G
V
D
N
G
S
S
P
D
H
D
S
Y
--
Q
A
D
N
---
R
K
A
F
S
G
K
V
L
A
I
V
Q
S
T
K
E
A
G
E
I
T
V
T
A
K
A
D
G
L
Q
S
S
T
V
K
I
A
T
T
A
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.37
49%
56
- C1 -
-
4YPJ
-
?
A:
[45-844]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
R
V
N
F
N
E
N
W
R
F
Q
R
E
T
N
G
S
I
A
G
--
A
Q
N
P
G
F
D
D
S
S
W
R
K
L
N
L
P
H
D
W
S
I
---
E
L
D
F
N
K
N
S
L
-
A
T
H
E
G
G
Y
L
D
G
G
I
G
W
Y
R
K
T
F
T
I
P
E
S
M
K
G
K
R
I
S
L
D
F
D
G
V
Y
M
N
S
T
T
Y
L
N
G
E
V
L
G
T
Y
P
F
G
Y
N
A
F
S
Y
D
I
S
D
K
L
Y
K
D
G
R
A
N
V
L
V
V
K
V
N
N
-
T
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
N
V
Y
L
T
V
T
D
P
I
H
V
A
R
-----
Y
G
T
F
V
T
T
P
N
L
E
K
S
I
K
-
E
D
R
A
D
V
N
I
K
T
K
I
S
N
D
A
A
E
A
K
Q
V
K
I
K
S
T
I
Y
D
G
A
G
N
--
T
V
Q
-
T
--
V
E
T
E
E
K
T
A
A
A
G
T
V
T
P
F
E
-
Q
N
T
-
V
I
K
Q
P
K
L
W
S
I
--
D
K
P
Y
R
Y
N
L
V
T
E
V
I
V
G
--
G
Q
T
V
D
T
Y
E
T
K
F
G
V
R
Y
F
K
F
D
E
N
E
G
F
S
L
N
G
E
Y
M
K
L
H
G
V
S
M
H
H
D
L
G
A
L
G
A
A
T
N
A
R
G
V
E
R
Q
M
Q
I
M
K
-
D
M
G
V
N
A
I
R
V
T
H
N
P
A
S
P
E
L
L
E
A
A
N
K
L
G
L
F
I
I
E
E
A
F
D
S
W
A
Q
S
K
--
K
P
Y
--
D
Y
G
R
F
F
--------------------
N
A
W
A
E
H
D
I
K
E
M
V
D
R
G
K
N
E
P
A
I
I
M
W
S
I
G
-
N
E
I
Y
D
T
-
T
-------------
N
A
A
G
V
-
E
T
A
R
N
L
V
G
W
V
K
E
I
D
T
T
R
P
T
T
I
G
E
D
K
T
R
---
G
D
K
VNVTPI
N
S
Y
I
K
E
I
F
N
I
V
D
V
----
V
G
L
N
Y
S
E
---
N
---
N
Y
-----------
D
G
----------------
Y
H
K
Q
N
---
P
S
W
K
L
Y
G
S
E
T
S
S
A
T
R
S
R
G
V
Y
T
H
P
Y
Q
-------------
Y
N
Q
------------------------
S
T
K
--------------
Y
A
D
L
Q
Q
S
S
Y
D
N
----------------------
D
Y
V
------
G
W
G
R
T
A
E
D
A
W
--
K
Y
D
R
D
L
K
H
I
A
G
Q
F
I
W
T
G
F
D
Y
I
G
E
P
T
P
Y
Y
-------
N
S
Y
P
A
------
K
S
S
Y
F
G
A
V
D
T
A
G
F
P
K
D
I
F
Y
Y
Y
Q
S
Q
W
---
K
K
E
P
M
V
H
L
L
P
--
H
W
N
W
K
E
G
E
-----------
K
-
V
R
V
L
A
Y
T
N
A
S
K
V
E
L
V
L
N
G
E
------
S
------
L
G
E
K
N
Y
D
N
K
Q
T
S
W
G
A
P
Y
K
-------
E
T
K
D
-
G
-
K
-----
T
Y
L
E
W
A
V
P
F
K
P
G
--
K
L
E
A
V
A
K
D
E
N
G
K
V
I
------
A
------
R
D
Q
V
V
T
A
G
E
P
A
S
V
R
L
T
A
D
R
K
V
V
K
A
D
G
T
D
L
S
F
I
T
A
D
I
V
D
S
K
G
I
V
V
P
D
A
D
H
L
I
T
F
N
V
T
G
Q
G
E
L
A
G
V
D
N
G
N
A
S
S
V
E
R
Y
K
D
N
K
-----
R
K
A
F
S
G
K
A
L
A
I
V
Q
S
S
K
L
S
G
K
I
T
V
H
A
S
V
A
G
L
S
S
D
S
T
S
V
F
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
61.16
41%
37
* C1 *
-
5DMY
2
?
A:
[35-886]
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
R
T
S
D
F
D
A
N
W
K
F
M
--
L
S
D
S
V
-
Q
--
A
Q
D
P
A
F
D
D
S
A
W
Q
Q
V
D
L
P
H
D
Y
S
I
---
T
Q
K
Y
S
Q
S
N
---
E
A
E
S
A
Y
L
P
G
G
T
G
W
Y
R
K
S
F
T
I
D
R
D
L
A
G
K
R
I
A
I
N
F
D
G
V
Y
M
N
A
T
V
W
F
N
G
V
K
L
G
T
H
P
Y
G
Y
S
P
F
S
F
D
L
T
G
N
A
K
F
G
G
-
E
N
T
I
V
V
K
V
E
N
-
R
-
L
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
T
V
T
D
G
V
H
V
G
N
-----
N
G
V
A
I
K
T
P
S
L
A
T
Q
-
N
-
G
G
N
V
T
M
N
L
T
T
K
V
A
N
D
T
E
A
A
A
N
I
T
L
K
Q
T
V
F
P
K
G
G
K
--
T
D
A
A
I
G
T
V
T
T
A
S
K
S
I
A
A
G
A
S
A
D
V
T
-
S
T
I
-
T
A
A
S
P
K
L
W
S
I
--
K
N
P
N
L
Y
T
V
R
T
E
V
L
N
G
--
D
T
V
L
D
T
Y
D
T
E
Y
G
F
R
W
T
G
F
D
A
T
S
G
F
S
L
N
G
E
K
V
K
L
K
G
V
S
M
H
H
D
Q
G
S
L
G
A
V
A
N
R
R
A
I
E
R
Q
V
E
I
L
Q
-
K
M
G
V
N
S
I
R
T
T
H
N
P
A
A
K
A
L
I
D
V
C
N
E
K
G
V
L
V
V
E
E
V
F
D
M
W
N
R
S
K
--
N
G
N
TE
D
Y
G
K
W
F
G
Q
T
I
A
GD
N
A
V
L
G
G
D
K
D
----
E
T
W
A
K
F
D
L
T
S
T
I
N
R
D
R
N
A
P
S
V
I
M
W
S
L
G
-
N
E
M
M
E
G
-
I
S
GS----------
V
S
D
F
P
-
A
T
S
A
K
L
V
A
W
T
K
A
A
D
S
T
R
P
M
T
Y
G
D
N
K
I
K
A
NW
N
E
S
------
N
T
M
G
D
N
L
T
A
N
G
G
V
----
V
G
T
N
Y
S
D
---
G
A
--
N
Y
-----------
D
K
----------------
I
R
T
T
H
---
P
S
W
A
I
Y
G
S
E
T
A
S
A
I
N
S
R
G
I
Y
N
R
T
T
G
----------------------------------------------------------
S
D
K
Q
L
T
S
Y
D
N
----------------------
S
A
V
------
G
W
G
A
V
A
S
S
A
W
--
Y
D
V
V
Q
R
D
F
V
A
G
T
Y
V
W
T
G
F
D
Y
L
G
E
P
T
P
W
N
G
T
G
S
G
A
V
G
S
W
P
S
P-----
K
N
S
Y
F
G
I
V
D
T
A
G
F
P
K
D
T
Y
Y
F
Y
Q
S
Q
W
N
D
--
D
V
H
T
L
H
I
L
P
--
A
W
N
E
N
V
V
A
-----
K
G
S
G
N
-
K
-
V
P
V
V
V
Y
T
D
A
A
K
V
K
L
Y
F
T
P
K
GST
E
K
R
L
------
I
G
E
K
S
F
T
K
K
T
T
A
A
G
Y
T
Y
Q
V
Y
EGTDK
D
S
T
A
-
H
K
N
-----
M
Y
L
T
W
N
V
P
W
A
E
G
--
T
I
S
A
E
A
Y
D
E
N
N
R
L
I
------
P
EGS
T
E
G
N
A
S
V
T
T
T
G
K
A
A
K
L
K
A
D
A
D
R
K
T
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T
A
D
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K
D
L
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Y
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E
V
D
V
T
D
A
N
G
H
I
V
P
D
A
A
N
R
V
T
F
D
V
K
G
A
G
K
L
V
G
V
D
N
G
S
S
P
D
H
D
S
Y
Q
A
D
-----
N
R
K
A
F
S
G
K
V
L
A
I
V
Q
S
T
K
E
A
G
E
I
T
V
T
A
K
A
D
G
L
Q
S
S
T
V
K
I
A
T
T
A
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
60.64
41%
40
- C1 -
-
5DMY
-
?
B:
[35-886]
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
R
T
S
D
F
D
A
N
W
K
F
M
--
L
S
D
S
V
-
Q
--
A
Q
D
P
A
F
D
D
S
A
W
Q
Q
V
D
L
P
H
D
Y
S
I
---
T
Q
K
Y
S
Q
S
N
---
E
A
E
S
A
Y
L
P
G
G
T
G
W
Y
R
K
S
F
T
I
D
R
D
L
A
G
K
R
I
A
I
N
F
D
G
V
Y
M
N
A
T
V
W
F
N
G
V
K
L
G
T
H
P
Y
G
Y
S
P
F
S
F
D
L
T
G
N
A
K
F
G
G
-
E
N
T
I
V
V
K
V
E
N
-
R
-
L
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
D
V
T
L
T
V
T
D
G
V
H
V
G
N
-----
N
G
V
A
I
K
T
P
S
L
A
T
Q
-
N
-
G
G
N
V
T
M
N
L
T
T
K
V
A
N
D
T
E
A
A
A
N
I
T
L
K
Q
T
V
F
P
K
G
G
K
--
T
D
A
A
I
G
T
V
T
T
A
S
K
S
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A
A
G
A
S
A
D
V
T
-
S
T
I
-
T
A
A
S
P
K
L
W
S
I
--
K
N
P
N
L
Y
T
V
R
T
E
V
L
N
G
--
D
T
V
L
D
T
Y
D
T
E
Y
G
F
R
W
T
G
F
D
A
T
S
G
F
S
L
N
G
E
K
V
K
L
K
G
V
S
M
H
H
D
Q
G
S
L
G
A
V
A
N
R
R
A
I
E
R
Q
V
E
I
L
Q
-
K
M
G
V
N
S
I
R
T
T
H
N
P
A
A
K
A
L
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V
C
N
E
K
G
V
L
V
V
E
E
V
F
D
M
W
N
R
S
K
--
N
G
N
TE
D
Y
G
K
W
F
G
Q
T
I
A
GD
N
A
V
L
G
G
D
K
D
----
E
T
W
A
K
F
D
L
T
S
T
I
N
R
D
R
N
A
P
S
V
I
M
W
S
L
G
-
N
E
M
M
E
G
-
I
S
GS----------
V
S
D
F
P
-
A
T
S
A
K
L
V
A
W
T
K
A
A
D
S
T
R
P
M
T
Y
G
D
N
K
I
K
A
NW
N
E
S
------
N
T
M
G
D
N
L
T
A
N
G
G
V
----
V
G
T
N
Y
S
D
---
G
A
--
N
Y
-----------
D
K
----------------
I
R
T
T
H
---
P
S
W
A
I
Y
G
S
E
T
A
S
A
I
N
S
R
G
I
Y
N
R
T
T
G
-----------
G
A
Q
-------------------------------------------
S
S
D
K
Q
L
T
S
Y
D
N
----------------------
S
A
V
------
G
W
G
A
V
A
S
S
A
W
--
Y
D
V
V
Q
R
D
F
V
A
G
T
Y
V
W
T
G
F
D
Y
L
G
E
P
T
P
W
N
G
T
G
S
G
A
V
G
S
W
P
S
P-----
K
N
S
Y
F
G
I
V
D
T
A
G
F
P
K
D
T
Y
Y
F
Y
Q
S
Q
W
N
D
--
D
V
H
T
L
H
I
L
P
--
A
W
N
E
N
V
V
A
-----
K
G
S
G
N
-
K
-
V
P
V
V
V
Y
T
D
A
A
K
V
K
L
Y
F
T
P
K
GST
E
K
R
L
------
I
G
E
K
S
F
T
K
K
T
T
A
A
G
Y
T
Y
Q
V
Y
EGTDK
D
S
T
A
-
H
K
N
-----
M
Y
L
T
W
N
V
P
W
A
E
G
--
T
I
S
A
E
A
Y
D
E
N
N
R
L
I
------
P
EGS
T
E
G
N
A
S
V
T
T
T
G
K
A
A
K
L
K
A
D
A
D
R
K
T
I
T
A
D
G
K
D
L
S
Y
I
E
V
D
V
T
D
A
N
G
H
I
V
P
D
A
A
N
R
V
T
F
D
V
K
G
A
G
K
L
V
G
V
D
N
G
S
S
P
D
H
D
S
Y
Q
A
D
-----
N
R
K
A
F
S
G
K
V
L
A
I
V
Q
S
T
K
E
A
G
E
I
T
V
T
A
K
A
D
G
L
Q
S
S
T
V
K
I
A
T
T
A
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
60.54
51%
58
- C1 -
-
4YPJ
-
?
A:
[40-838]
------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
D
G
E
R
R
V
N
F
N
E
N
W
R
F
Q
--
R
E
T
N
G
S
I
AG
A
Q
N
P
G
F
D
D
S
S
W
R
K
L
N
L
P
H
D
W
S
I
---
E
L
D
F
N
K
N
S
L
-
A
T
H
E
G
G
Y
L
D
G
G
I
G
W
Y
R
K
T
F
T
I
P
E
S
M
K
G
K
R
I
S
L
D
F
D
G
V
Y
M
N
S
T
T
Y
L
N
G
E
V
L
G
T
Y
P
F
G
Y
N
A
F
S
Y
D
I
S
D
K
L
Y
K
D
G
R
A
N
V
L
V
V
K
V
N
N
-
T
-
Q
-----
P
-----
S
---
S
R
W
Y
S
G
S
G
I
Y
R
N
V
Y
L
T
V
T
D
P
I
H
V
A
R
-----
Y
G
T
F
V
T
T
P
N
L
E
K
S
-
I
K
E
D
R
A
D
V
N
I
K
T
K
I
S
N
D
A
A
E
A
K
Q
V
K
I
K
S
T
I
Y
D
G
A
G
N
--
T
V
Q
T
V
---
E
T
E
E
K
T
A
A
A
G
T
V
T
P
F
E
-
Q
N
T
-
V
I
K
Q
P
K
L
W
S
I
--
D
K
P
Y
R
Y
N
L
V
T
E
V
I
V
G
--
G
Q
T
V
D
T
Y
E
T
K
F
G
V
R
Y
F
K
F
D
E
N
E
G
F
S
L
N
G
E
Y
M
K
L
H
G
V
S
M
H
H
D
L
G
A
L
G
A
A
T
N
A
R
G
V
E
R
Q
M
Q
I
M
K
-
D
M
G
V
N
A
I
R
V
T
H
N
P
A
S
P
E
L
L
E
A
A
N
K
L
G
L
F
I
I
E
E
A
F
D
S
W
A
Q
S
K
--
K
P
Y
--
D
----------------
Y
G
R
F
F
----
N
A
W
A
E
H
D
I
K
E
M
V
D
R
G
K
N
E
P
A
I
I
M
W
S
I
G
-
N
E
I
Y
D
T
-
T
-------------
N
A
A
G
V
-
E
T
A
R
N
L
V
G
W
V
K
E
I
D
T
T
R
P
T
T
I
G
E
D
K
T
R
G
--
D
K
V
NVTPI-
N
S
Y
I
K
E
I
F
N
I
V
D
V
----
V
G
L
N
Y
S
E
---
N
---
N
Y
-----------
D
G
----------------
Y
H
K
Q
N
---
P
S
W
K
L
Y
G
S
E
T
S
S
A
T
R
S
R
G
V
Y
T
H
P
Y
Q
-----------
Y
N
Q
S
--------------------------
T
K
--------------
Y
A
D
L
Q
Q
S
S
Y
D
N
----------------------
D
Y
V
------
G
W
G
R
T
A
E
D
A
W
--
K
Y
D
R
D
L
K
H
I
A
G
Q
F
I
W
T
G
F
D
Y
I
G
E
P
T
P
Y
Y
N
-------
S
Y
P
A
------
K
S
S
Y
F
G
A
V
D
T
A
G
F
P
K
D
I
F
Y
Y
Y
Q
S
Q
W
K
---
K
E
P
M
V
H
L
L
P
--
H
W
N
W
K
E
----------
G
E
-
K
-
V
R
V
L
A
Y
T
N
A
S
K
V
E
L
V
L
N
G
E
------
S
------
L
G
E
K
N
Y
D
N
K
Q
T
S
W
G
A
P
Y
K
-------
E
T
K
--
D
G
K
-----
T
Y
L
E
W
A
V
P
F
K
P
G
--
K
L
E
A
V
A
K
D
E
N
G
K
V
I
------
A
------
R
D
Q
V
V
T
A
G
E
P
A
S
V
R
L
T
A
D
R
K
V
V
K
A
D
G
T
D
L
S
F
I
T
A
D
I
V
D
S
K
G
I
V
V
P
D
A
D
H
L
I
T
F
N
V
T
G
Q
G
E
L
A
G
V
D
N
G
N
A
S
S
V
E
R
Y
K
D
N
-----
K
R
K
A
F
S
G
K
A
L
A
I
V
Q
S
S
K
L
S
G
K
I
T
V
H
A
S
V
A
G
L
S
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
54.83
33%
25
- C1 -
-
3GM8
2
?
A:
[4-798]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
I
N
F
C
K
G
W
K
F
H
--
L
G
D
A
G
K
G
--
A
S
S
S
S
Y
N
D
S
Q
W
R
I
L
N
I
P
H
D
W
S
I
---
E
G
T
Y
K
Q
F
E
N
G
T
D
W
Q
S
G
F
L
P
A
G
I
S
W
Y
R
K
T
F
T
I
P
S
K
W
K
N
K
K
V
Q
I
L
F
E
G
V
Y
L
N
S
E
V
W
I
N
G
H
W
L
G
K
R
P
N
G
Y
I
S
F
V
Y
D
L
T
P
Y
L
Q
E
G
--
K
N
Q
I
A
V
K
V
D
H
S
K
-
A
-----
L
-----
T
---
G
R
W
Y
T
G
S
G
I
Y
R
P
V
Y
L
L
V
S
N
P
T
H
I
P
Y
-----
S
G
I
H
F
R
S
K
L
Q
N
K
Q
-----
S
A
T
Y
T
L
S
I
E
I
E
T
Q
E
K
K
P
--
I
K
V
K
T
Y
L
Q
A
P
N
G
S
-------------
I
A
D
T
S
E
K
I
F
V
L
C
F
-
L
S
G
-
S
I
R
K
P
L
L
W
S
P
--
D
S
P
N
V
Y
T
L
I
C
Q
L
T
R
D
--
N
K
I
L
D
E
C
R
L
P
V
G
F
R
Q
L
E
F
N
P
V
S
G
F
L
L
N
G
K
S
L
K
I
K
G
V
C
D
H
H
T
V
G
A
V
G
A
A
V
P
D
D
L
L
H
Y
R
L
K
L
L
K
-
D
M
G
C
N
A
I
R
T
S
H
N
P
F
S
P
A
F
Y
N
L
C
D
T
M
G
I
M
V
L
N
E
G
L
D
G
W
N
Q
P
K
--
A
A
D
--
D
Y
G
N
Y
----------------
F
----
D
E
W
W
Q
K
D
M
T
D
F
I
K
R
D
R
N
H
P
S
I
I
M
W
S
I
G
-
N
E
V
T
G
------------------
A
T
P
-
E
I
Q
H
N
L
V
S
L
F
H
Q
L
D
P
D
R
P
V
T
Q
G
G
T
D
---------------------
P
N
Y
L
D
I
----
I
G
F
N
G
N
G
EEI
G
---
E
L
-----------
E
H
----------------
F
H
K
N
Y
---
P
T
L
C
A
I
A
T
E
V
P
H
T
Y
Q
T
R
G
V
Y
R
S
Q
T
Q
-----------
W
R
R
R
D
------------------------
F
P
A
--------------
P
W
E
F
K
H
R
V
F
P
I
PDLTEKECFPEESDYPY
Y
Q
S
SY
D
N
A
------
S
V
R
I
S
A
R
K
S
W
--
Q
R
T
C
S
F
P
W
L
M
G
E
F
R
W
G
S
F
D
Y
L
G
E
A
E
W
------------
P
Q
------
R
C
G
N
F
G
I
I
D
I
A
A
I
P
K
D
A
Y
F
L
Y
Q
S
L
W
---
T
D
K
P
M
V
H
L
L
P
--
H
W
T
H
P
G
K
E
--------
G
K
-
T
-
I
P
V
V
I
Y
T
N
C
D
A
V
E
L
F
I
N
N
V
------
S
------
L
G
S
K
P
Y
T
G
E
Q
------------------------------
L
I
W
L
V
P
Y
S
P
G
--
K
I
E
A
R
G
I
K
K
-
G
K
I
V
------
A
------
T
D
C
Y
Q
S
A
E
A
P
H
S
V
A
L
A
S
N
K
Y
S
V
K
A
G
S
D
E
V
I
R
I
E
I
D
I
T
D
K
N
G
I
P
C
P
Y
A
S
N
E
L
S
F
H
V
S
G
P
L
R
L
L
G
V
D
N
G
N
P
T
D
M
F
P
Y
Q
Q
P
-----
H
C
R
C
F
R
G
K
C
V
V
L
L
Q
S
D
E
E
K
G
K
G
T
L
T
V
Q
G
T
K
L
V
E
K
K
L
I
I
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
54.09
32%
25
- C1 -
-
3GM8
2
?
A:
[4-798]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
E
T
I
N
F
C
K
G
W
K
F
H
--
L
G
D
A
G
K
G
--
A
S
S
S
S
Y
N
D
S
Q
W
R
I
L
N
I
P
H
D
W
S
I
---
E
G
T
Y
K
Q
F
E
N
G
T
D
W
Q
S
G
F
L
P
A
G
I
S
W
Y
R
K
T
F
T
I
P
S
K
W
K
N
K
K
V
Q
I
L
F
E
G
V
Y
L
N
S
E
V
W
I
N
G
H
W
L
G
K
R
P
N
G
Y
I
S
F
V
Y
D
L
T
P
Y
L
Q
E
-
G
-
K
N
Q
I
A
V
K
V
D
H
-
S
K
A
-----
L
-----
T
---
G
R
W
Y
T
G
S
G
I
Y
R
P
V
Y
L
L
V
S
N
P
T
H
I
P
Y
-----
S
G
I
H
F
R
S
K
L
Q
N
-
K
----
Q
S
A
T
Y
T
L
S
I
E
I
E
T
Q
E
K
--
K
P
I
K
V
K
T
Y
L
Q
A
P
N
G
S
--
I
A
D
T
S
-----
E
K
I
F
V
------
L
C
F
-
L
S
G
-
S
I
R
K
P
L
L
W
S
P
--
D
S
P
N
V
Y
T
L
I
C
Q
L
T
R
D
--
N
K
I
L
D
E
C
R
L
P
V
G
F
R
Q
L
E
F
N
P
V
S
G
F
L
L
N
G
K
S
L
K
I
K
G
V
C
D
H
H
T
V
G
A
V
G
A
A
V
P
D
D
L
L
H
Y
R
L
K
L
L
K
-
D
M
G
C
N
A
I
R
T
S
H
N
P
F
S
P
A
F
Y
N
L
C
D
T
M
G
I
M
V
L
N
E
G
L
D
G
W
N
Q
P
K
--
A
A
D
--
D
----------------
Y
G
N
Y
F
----
D
E
W
W
Q
K
D
M
T
D
F
I
K
R
D
R
N
H
P
S
I
I
M
W
S
I
G
-
N
E
V
T
G
A
-
T
-----------------
P
-
E
I
Q
H
N
L
V
S
L
F
H
Q
L
D
P
D
R
P
V
T
Q
G
G
T
D
P
---------------------
N
Y
L
D
I
----
I
G
F
N
G
N
G
---
E
EIG
E
L
-----------
E
H
----------------
F
H
K
N
Y
---
P
T
L
C
A
I
A
T
E
V
P
H
T
Y
Q
T
R
G
V
Y
R
S
Q
T
Q
-----------
W
R
R
R
D
FPAPWEFKHRVFPIPDLTEKECFP
E
E
S
--------------
D
Y
P
Y
Y
Q
S
S
Y
D
N
----------------------
A
--------
S
V
R
I
S
A
R
K
S
W
--
Q
R
T
C
S
F
P
W
L
M
G
E
F
R
W
G
S
F
D
Y
L
G
E
A
E
------------
W
P
Q
------
R
C
G
N
F
G
I
I
D
I
A
A
I
P
K
D
A
Y
F
L
Y
Q
S
L
W
T
---
D
K
P
M
V
H
L
L
P
--
H
W
T
H
P
G
--------
K
E
G
K
-
T
-
I
P
V
V
I
Y
T
N
C
D
A
V
E
L
F
I
N
N
V
------
S
------
L
G
S
K
P
Y
T
-------------------------
G
-----
E
Q
L
I
W
L
V
P
Y
S
P
G
--
K
I
E
A
R
G
I
K
-
K
G
K
I
V
------
A
------
T
D
C
Y
Q
S
A
E
A
P
H
S
V
A
L
A
S
N
K
Y
S
V
K
A
G
S
D
E
V
I
R
I
E
I
D
I
T
D
K
N
G
I
P
C
P
Y
A
S
N
E
L
S
F
H
V
S
G
P
L
R
L
L
G
V
D
N
G
N
P
T
D
M
F
P
Y
Q
Q
P
-----
H
C
R
C
F
R
G
K
C
V
V
L
L
Q
S
D
E
E
K
G
K
G
T
L
T
V
Q
G
T
K
L
V
E
K
K
L
I
I
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.95
31%
31
- C1 -
-
3GM8
2
?
A:
[7-796]
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
F
C
K
G
W
K
F
H
--
L
G
D
A
G
K
G
--
A
S
S
S
S
Y
N
D
S
Q
W
R
I
L
N
I
P
H
D
W
S
I
E
G
T
Y
K
Q
F
E
N
G
T
D
-
W
Q
S
--
G
F
L
P
A
G
I
S
W
Y
R
K
T
F
T
I
P
S
K
W
K
N
K
K
V
Q
I
L
F
E
G
V
Y
L
N
S
E
V
W
I
N
G
H
W
L
G
K
R
P
N
G
Y
I
S
F
V
Y
D
L
T
P
Y
L
-
Q
E
G
K
N
Q
I
A
V
K
V
D
H
S
-
K
-
A
-----
L
-----
T
---
G
R
W
Y
T
G
S
G
I
Y
R
P
V
Y
L
L
V
S
N
P
T
H
I
P
Y
-----
S
G
I
H
F
R
S
-
K
L
Q
N
K
-
Q
-
S
A
---
T
Y
T
L
S
I
E
I
E
T
Q
E
K
K
P
I
K
V
K
T
Y
L
------
Q
--
A
P
N
G
S
--
I
A
D
T
S
E
K
I
F
V
-----
L
C
-
F
L
S
G
S
I
R
K
P
L
L
W
S
--
P
D
S
P
N
V
Y
T
L
I
C
Q
L
T
R
D
--
N
K
I
L
D
E
C
R
L
P
V
G
F
R
Q
L
E
F
N
P
V
S
G
F
L
L
N
G
K
S
L
K
I
K
G
V
C
D
H
H
T
V
G
A
V
G
A
A
V
P
D
D
L
L
H
Y
R
L
K
L
L
K
-
D
M
G
C
N
A
I
R
T
S
H
N
P
F
S
P
A
F
Y
N
L
C
D
T
M
G
I
M
V
L
N
E
G
L
D
G
W
N
Q
P
K
--
A
A
D
--
D
Y
G
N
Y
F
--------------------
D
E
W
W
Q
K
D
M
T
D
F
I
K
R
D
R
N
H
P
S
I
I
M
W
S
I
G
-
N
E
V
T
G
A
-
T
P
------------
E
I
Q
------
H
N
L
V
S
L
F
H
Q
L
D
P
D
R
P
V
T
Q
G
G
T
D
P
---------------------
N
Y
L
D
I
----
I
G
F
N
G
N
G
---
E
---
E
I
-----------
G
E
----------------
L
E
H
F
H
K
N
Y
P
T
L
C
A
I
A
T
E
V
P
H
T
Y
Q
T
R
G
V
Y
R
S
Q
T
Q
W
RRRDFPAPWE-
F
K
H
R
------------------------
V
F
P
IPDLTEKECFPEES
D
Y
P
Y
Y
Q
S
S
Y
D
N
----------------------
A
S
V
RIS
A
R
K
S
W
Q
R
T
C
S
F
P
W
--
L
M
--------
G
E
F
R
W
G
S
F
D
Y
L
G
E
A
------------
E
W
P
Q
------
R
C
G
N
F
G
I
I
D
I
A
A
I
P
K
D
A
Y
F
L
Y
Q
S
L
W
T
D
---
K
P
M
V
H
L
L
P
--
H
W
T
H
P
G
K
---------
E
G
-
K
T
I
P
V
V
I
Y
T
N
C
D
A
V
E
L
F
I
N
N
V
------
S
------
L
G
S
K
P
Y
T
G
E
Q
------------------------------
L
I
W
L
V
P
Y
S
P
G
--
K
I
E
A
R
G
I
-
K
K
G
K
I
V
------
A
------
T
D
C
Y
Q
S
A
E
A
P
H
S
V
A
L
A
S
N
K
Y
S
V
K
A
G
S
D
E
V
I
R
I
E
I
D
I
T
D
K
N
G
I
P
C
P
Y
A
S
N
E
L
S
F
H
V
S
G
P
L
R
L
L
G
V
D
N
G
N
P
T
D
M
F
P
Y
Q
Q
P
H
-----
C
R
C
F
R
G
K
C
V
V
L
L
Q
S
D
E
E
K
G
K
G
T
L
T
V
Q
G
T
K
L
V
E
K
K
L
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
45.18
26%
30
- C1 -
-
5UJ6
3
?
B:
[24-709]
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Q
T
Q
T
I
N
D
S
W
K
F
L
--
K
G
E
C
T
-
A
--
A
A
D
S
A
F
D
D
S
K
W
T
S
I
H
L
P
H
T
W
N
T
---
D
A
-
Y
T
---------
E
K
D
Y
Y
R
G
T
G
W
Y
R
R
Q
L
T
L
P
Q
G
W
K
E
K
Q
I
I
L
R
L
D
A
A
G
K
S
A
T
I
Y
I
N
G
K
N
V
G
E
H
A
G
G
Y
T
A
C
S
F
N
I
T
P
F
L
S
F
D
T
-
P
N
T
L
A
V
C
V
D
N
-
A
-
R
-----
Q
DIAPI
S
---
G
D
F
T
F
F
G
G
I
Y
R
D
V
W
L
T
A
V
P
N
Q
H
F
N
L
TNHGS
D
G
L
F
I
S
T
P
Q
V
S
E
-----
E
Q
A
T
L
S
I
R
G
E
V
K
N
D
A
P
E
K
A
T
L
E
L
T
H
T
I
Y
R
P
D
G
T
--
L
L
Q
T
L
----
K
K
N
I
Q
L
K
A
G
E
T
Y
A
F
S
N
E
A
T
-
P
V
L
K
P
E
L
W
T
P
--
E
T
P
R
L
Y
R
V
E
T
T
L
R
N
R
KT
K
T
L
L
D
Q
S
N
H
Y
T
A
F
R
W
F
R
F
D
G
D
E
G
F
F
L
N
G
K
P
Y
K
L
R
G
I
C
R
H
Q
D
Q
K
P
I
G
P
A
L
T
D
E
M
H
R
R
D
F
L
L
M
K
-
E
M
G
A
N
F
I
R
I
S
H
Y
P
Q
D
D
A
L
L
E
M
C
D
K
L
G
M
L
A
W
E
E
I
P
I
I
D
I
V
P
N
-------------------------
T
P
G
Y
----
G
D
N
C
E
R
N
L
R
E
M
I
R
Q
H
Y
N
H
P
S
I
I
T
W
G
Y
M
-
N
E
I
L
L
V
-
T
Q
RKYKTEAELKPV
L
E
R
T
L
-
A
L
A
N
R
L
E
R
V
L
K
E
E
D
S
T
R
I
S
T
M
A
F
H
G
S
N
S
--
Y
----------
N
E
T
G
L
S
K
I
T
D
I
----
V
G
W
N
L
Y
Q
---
G
---
W
Y
GGDLTGFEKFL
A
Q
----------------
Q
H
Q
N
H
---
P
T
H
P
M
I
V
S
E
Y
G
A
G
S
D
K
R
L
H
S
L
H
P
R
A
-----------
F
D
--------------------------------------------
F
S
I
E
Y
Q
Q
--------------------------------------
K
Y
L
E
H
Y
L
--
P
V
L
E
D
T
P
Y
I
C
G
G
T
H
W
N
F
I
D
F
S
S
A
L
R
D
E
---------
S
M
P
R
-------
I
N
N
K
G
L
V
Y
A
D
R
T
P
K
D
V
Y
H
Y
Y
Q
A
A
W
R
K
--
D
I
P
V
L
H
I
A
S
---
R
D
W
T
D
R
A
G
V
-
Q
Q
G
N
A
P
V
-
Y
-
L
P
V
K
I
Y
T
N
L
S
E
V
E
L
F
I
D
G
I
------
S
------
L
G
K
Q
K
T
-------------------------
E
N
-----
Y
T
A
T
F
E
V
P
F
S
N
R
NP
F
L
F
A
Q
G
N
Y
-
Q
G
K
T
V
-------------
Q
D
G
L
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.32
98%
-35
* C2 *
-
4CUA
7
?
A:
[4-181]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
A
N
I
S
D
Q
W
T
G
S
E
L
P
L
A
F
A
S
D
S
N
P
S
D
P
V
S
N
V
N
D
K
L
I
S
Y
N
N
Q
P
A
N
R
W
T
N
W
N
R
S
N
P
E
A
S
V
G
V
L
F
G
D
S
G
I
L
S
K
R
S
V
D
N
L
S
V
G
F
H
E
D
H
G
V
G
A
P
K
S
Y
V
I
E
Y
Y
V
G
K
T
V
P
T
A
P
K
N
P
S
F
V
G
N
E
D
H
V
F
N
D
S
A
N
W
K
P
V
T
N
L
K
A
P
A
Q
L
K
A
G
E
M
N
H
F
S
F
D
K
V
E
T
Y
A
I
R
I
R
M
V
K
A
D
N
K
R
G
T
S
I
T
E
V
Q
I
F
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
40.71
99%
-50
- C2 -
-
4CU9
4
?
B:
[9-185]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
D
E
N
S
N
Q
A
F
A
S
A
T
N
D
I
D
K
N
S
H
D
R
V
D
Y
L
N
D
G
D
H
S
E
N
R
R
W
T
N
W
S
P
T
P
S
S
N
P
E
V
S
A
G
V
I
F
R
E
N
G
K
I
V
E
R
T
V
A
Q
A
K
L
H
F
F
A
D
S
G
T
D
A
P
S
K
L
V
L
E
R
Y
V
G
P
G
F
E
V
P
T
Y
Y
S
N
Y
Q
A
Y
E
S
G
H
P
F
N
N
P
E
N
W
E
A
V
P
Y
R
A
D
K
D
I
A
A
G
D
E
I
N
V
T
F
K
A
V
K
A
K
A
M
R
W
R
M
E
R
K
A
D
K
S
G
V
A
M
I
E
M
T
F
L
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
40.10
100%
-37
- C2 -
-
4CUB
6
?
B:
[3-182]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
G
A
N
I
S
D
Q
W
T
G
S
E
L
P
L
A
F
A
S
D
S
N
P
S
D
P
V
S
N
V
N
D
K
L
I
S
Y
N
N
Q
P
A
N
R
W
T
N
W
N
R
S
N
P
E
A
S
V
G
V
L
F
G
D
S
G
I
L
S
K
R
S
V
D
N
L
S
V
G
F
H
E
D
H
G
V
G
A
P
K
S
Y
V
I
E
Y
Y
V
G
K
T
V
P
T
A
P
K
N
P
S
F
V
G
N
E
D
H
V
F
N
D
S
A
N
W
K
P
V
T
N
L
K
A
P
A
Q
L
K
A
G
E
M
N
H
F
S
F
D
K
V
E
T
Y
A
I
R
I
R
M
V
K
A
D
N
K
R
G
T
S
I
T
E
V
Q
I
F
A
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
40.03
22%
24
- C1 -
-
5EUV
3
?
A:
[2-730]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
Q
K
L
N
H
G
W
I
F
A
--
E
G
A
A
D
P
--------
A
T
P
L
A
G
E
T
V
T
L
P
H
N
A
V
----
D
L
P
L
S
Y
F
-------
D
E
T
S
Y
Q
R
A
F
T
Y
Q
R
V
I
A
W
D
D
A
W
Q
G
R
R
V
Q
L
R
F
D
G
A
M
A
D
N
V
V
W
V
N
G
V
Q
V
V
A
H
P
D
G
Y
T
P
F
V
A
D
L
T
D
H
L
R
P
-
G
-
D
N
L
V
T
V
R
I
D
G
-
S
-
E
NPAIP
P
-----
F
GAQ
I
D
Y
L
T
Y
A
G
I
Y
R
D
V
W
L
M
V
L
P
E
R
H
L
T
N
-----
A
--
R
I
L
T
P
D
A
L
S
D
-----
A
K
T
V
V
I
R
P
E
V
T
A
P
------
G
P
V
R
A
R
L
L
D
G
D
R
E
--
I
A
A
T
E
------------
G
E
-
G
E
L
T
--
L
A
-
G
L
T
G
L
S
L
W
S
T
--
D
N
P
Q
L
Y
T
V
E
L
T
L
P
D
S
--
G
---
D
V
T
T
H
R
F
G
F
R
T
A
E
W
T
-
P
Q
G
F
L
L
N
G
Q
P
M
K
L
R
G
L
N
R
H
Q
S
W
A
H
Q
G
Y
A
A
G
R
H
A
Q
E
R
D
A
E
I
V
R
H
D
L
C
C
N
M
V
R
T
S
H
Y
P
Q
S
T
W
F
L
D
R
C
D
E
I
G
L
L
V
F
E
E
I
P
-
G
W
Q
H
I
G
--
D
-----------------------
Q
A
W
----
Q
D
R
S
V
D
N
V
R
A
M
I
T
R
D
W
N
H
P
S
I
V
I
W
G
V
R
I
N
E
S
P
D
N
-------------------
H
-
D
F
Y
V
R
T
N
A
L
A
R
E
L
D
P
T
R
A
I
G
G
V
R
C
I
T
D
------------------
S
E
M
L
E
D
V
----
Y
T
M
N
D
F
I
---
L
---
D
E
-----------
S
E
LPLINRPRTALRP
T
E
E
V
T
G
I
K
---
K
P
V
P
Y
L
V
T
E
Y
N
G
H
M
F
P
T
K
A
-
Q
D
P
E
L
------------------------------------------------------------
R
Q
M
E
H
V
------------------------------------
I
R
H
L
E
V
L
--
N
A
A
H
G
D
P
A
I
S
G
C
I
G
W
C
M
F
D
Y
N
T
H
K
-
D
F
---------
G
A
G
D
------
R
I
C
H
H
G
V
M
D
I
W
R
E
P
K
F
A
A
H
A
Y
G
S
Q
K
P
P
---
S
E
G
I
V
M
E
P
VT
F
W
A
R
G
E
-------
R
N
I
G
G
-
V
-
L
P
L
I
V
L
T
N
C
D
E
V
E
F
E
C
A
G
V
------
T
R
R
----
V
G
P
D
R
E
R
F
P
H
L
P
R
P
P
V
I
I
-------
D
H
R
H
I
S
A
E
-----
E
L
G
Q
W
G
M
S
W
H
P
G
--
R
I
T
--
G
W
L
-
N
G
E
Q
V
------
A
------
L
R
E
Y
V
A
D
P
L
P
T
T
L
Q
I
A
P
D
R
D
T
L
P
A
D
G
D
I
D
L
R
V
M
L
R
A
L
D
Q
V
G
N
R
L
P
F
L
D
A
G
I
A
V
T
V
D
G
P
A
R
L
I
G
P
D
------------------
L
R
M
L
Q
G
G
T
T
G
M
L
L
R
L
T
G
D
A
G
T
I
R
I
T
A
R
H
P
Q
F
P
E
A
V
A
T
V
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.56
100%
-39
- C2 -
-
4CUB
6
?
A:
[4-182]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
A
N
I
S
D
Q
W
T
G
S
E
L
P
L
A
F
A
S
D
S
N
P
S
D
P
V
S
N
V
N
D
K
L
I
S
Y
N
N
Q
P
A
N
R
W
T
N
W
N
R
S
N
P
E
A
S
V
G
V
L
F
G
D
S
G
I
L
S
K
R
S
V
D
N
L
S
V
G
F
H
E
D
H
G
V
G
A
P
K
S
Y
V
I
E
Y
Y
V
G
K
T
V
P
T
A
P
K
N
P
S
F
V
G
N
E
D
H
V
F
N
D
S
A
N
W
K
P
V
T
N
L
K
A
P
A
Q
L
K
A
G
E
M
N
H
F
S
F
D
K
V
E
T
Y
A
I
R
I
R
M
V
K
A
D
N
K
R
G
T
S
I
T
E
V
Q
I
F
A
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------