@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0627: (2017-12-26 )
MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEGYKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90......-.-.100.......110.........120.......130--...-----....140.......150.......160.......170.......180..---.....190-..-----------.....----.200-.-....-.-...210.......220.......230.......240.......250.......260.......270.......280-----..-----.....290.......300.......310.......320.......330.......340.......350.......360.......370......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSYKTSNAEG
H
V
D
F
I
NTYDL
E
P
M
A
Q
Q
V
I
P
K
A
A
F
G
Y
IASGAEDT
F
T
L
R
E
N
I
R
A
FN
H
K
LI
V
P
HTLCDVENPST
E
I
E
FAGEKLSS
P
I
I
MA
P
V
A
A
H
K
LANE-Q-GE
V
A
T
A
R
G
V
H
E
F
--G
S
L
YTTSSYSTV
D
L
P
E
I
S
E
A
LQ--GTP-----
H
W
F
Q
F
Y
FSKDDGI
N
R
H
I
M
D
R
V
KAEG
Y
K
A
I
V
L
T
A
DATVGGNREVDKRN
G
F
---
V
F
PV
G
M
P
--
I
V
-----------
E
E
YLP----EG---A-GK
S
M
-
D
-
F
V
Y
K
S
A
K
QRLSP
R
D
V
E
F
I
A
EYSG
L
P
V
Y
V
KGPQ
C
R
E
D
V
E
R
S
L
AAGA
S
G
I
W
V
TNHGGRQIDGG
P
A
A
F
D
S
L
Q
E
V
A
E
A
V
D-----RR-----V
P
I
V
FDSGVR
R
G
Q
H
V
F
K
A
L
ASGA
D
L
V
AIGR
P
V
I
Y
G
L
ALGGS
V
G
V
R
Q
V
F
E
H
L
N
A
E
L
K
T
V
M
Q
LSGA
Q
T
I
E
D
V
K
H
F
K
L
RHNPYNPTFPVDPRDLKLY
29
PsiBlast_CBE
91.74
52%
-75
- C2 -
-
5EBU
2
?
H:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
--------------------------
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
33
PsiBlast_CBE
90.74
52%
-73
- C2 -
-
5EBU
2
?
D:
[6-370]
I
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
-------------------------
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
21
PsiBlast_CBE
90.45
52%
-36
- C2 -
-
4YL2
2
?
C:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
F
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
1
PsiBlast_PDB
90.30
52%
-34
- C2 -
-
4YL2
2
?
A:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
F
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
6
PsiBlast_PDB
90.13
52%
-75
- C2 -
-
2E77
2
?
A:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
--------------------
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
26
PsiBlast_CBE
89.54
52%
-36
- C2 -
-
2J6X
1
?
C:
[7-370]
-
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
24
PsiBlast_CBE
89.50
52%
-76
- C2 -
-
2J6X
1
?
F:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
-----------------
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
31
PsiBlast_CBE
89.26
52%
-38
- C2 -
-
5EBU
2
?
F:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
F
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
34
PsiBlast_CBE
89.25
52%
-36
- C2 -
-
5EBU
2
?
C:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
F
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
22
PsiBlast_CBE
88.95
52%
-34
- C2 -
-
4YL2
2
?
B:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
F
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
36
PsiBlast_CBE
88.92
52%
-83
- C2 -
-
2ZFA
2
?
B:
[7-370]
-
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
----------------------------------------------------------------
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
42
PsiBlast_CBE
88.91
52%
-34
- C2 -
-
2DU2
1
?
B:
[6-370]
I
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
41
PsiBlast_CBE
88.87
52%
-35
- C2 -
-
2DU2
1
?
C:
[6-370]
I
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
40
PsiBlast_CBE
88.79
52%
-33
- C2 -
-
2DU2
1
?
D:
[6-370]
I
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
39
PsiBlast_CBE
88.79
52%
-33
- C2 -
-
2E77
2
?
B:
[7-370]
-
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
37
PsiBlast_CBE
88.72
52%
-33
- C2 -
-
2E77
2
?
D:
[7-370]
-
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
43
PsiBlast_CBE
88.71
53%
-91
- C2 -
-
2NLI
3
?
B:
[10-364]
----------
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
-------------------------------------------------------------------
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
4
PsiBlast_PDB
88.66
52%
-34
- C2 -
-
5EBU
2
?
A:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
A
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
G
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
F
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
38
PsiBlast_CBE
88.53
52%
-73
- C2 -
-
2E77
1
?
C:
[7-370]
-
E
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
----------------------------------------
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
27
PsiBlast_CBE
88.51
52%
-33
- C2 -
-
2J6X
1
?
B:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
---
V
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
S
L
-
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
A
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
A
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
8
PsiBlast_PDB
86.53
53%
-36
- C2 -
-
2NLI
3
?
A:
[10-364]
----------
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
-----------
Y
P
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E
G
M
-------
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
7
PsiBlast_PDB
86.01
52%
-34
- C2 -
-
2ZFA
2
?
A:
[8-370]
--
Y
N
A
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
-----------
F
G
M
P
--
I
V
-----------
Q
R
Y
L
R
----
G
T
---
A
E---------
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
--------------
104
HHSearch
84.66
52%
-27
- C2 -
-
2NLI
3
?
A:
[5-368]
-----
P
S
E
I
K
Y
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
-
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
G
P
-----
R
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
-----------
Y
P
F
G
M
P
--
I
V
Q
R
YL-------
R
G
T
A
-------------
E
G
M
-----
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
-----
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
N
P
Y
G
Y
E
Y
----------
14
PsiBlast_PDB
75.00
34%
-37
- C2 -
-
2RDU
2
HAOX1_HUMAN
A:
[22-379]
-------------
L
I
C
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
P
--
E
A
L
-----
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
---
K
L
P
P
Q
L
R
--
M
K
NFETSTLSFSP
E
E
N
F
G
----
D
D
---
S
-
G
L
A
A
---
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
R
K
-----------------
94
HHSearch
74.02
35%
-23
- C2 -
-
2RDU
2
HAOX1_HUMAN
A:
[21-379]
------------
R
L
I
C
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
-
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
P
--
E
A
L
-----
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
---
K
L
P
P
Q
L
R
MK
N
F
-----------
E
T
S
T
L
SFSP
E
E
NFG
D
-
D
S
G
L
-
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
-----
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
R
K
-----------------
59
PsiBlast_CBE
61.87
31%
4
- C2 -
-
1KBJ
2
CYB2_YEAST
B:
[22-375]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
---------------------------------------
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
63
PsiBlast_CBE
61.24
31%
-1
- C2 -
-
1LDC
2
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-----------------------------------------------------
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
64
PsiBlast_CBE
61.10
31%
1
- C2 -
-
1LDC
3
CYB2_YEAST
A:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
--------------------------------------------
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
60
PsiBlast_CBE
61.05
31%
5
- C2 -
-
1KBJ
2
CYB2_YEAST
A:
[22-375]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S--------------------------------------
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
103
HHSearch
60.52
31%
5
- C2 -
-
1KBI
3
CYB2_YEAST
B:
[124-484]
---------------
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
-
L
E
G
E
K
D
V
A
R
G
C
G
Q
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
P
SD
K
Q
I
-----
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
---
S
N
T
---------------------
K
T
N
----
V
E
---
E
-
S
Q
G
A
S
R
-
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
NLK
D
K
-----
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
D
L
S
T
L
K
-------------
57
PsiBlast_CBE
60.39
31%
1
- C2 -
-
1FCB
2
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S------------------------
N
V
E
E
S
----
Q
G
---
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
66
PsiBlast_CBE
60.26
31%
0
- C2 -
-
1LCO
3
CYB2_YEAST
A:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S------------------------------------------
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
65
PsiBlast_CBE
60.14
31%
5
- C2 -
-
1LCO
2
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
F
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
-----------------------------------
Q
G
---
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
56
PsiBlast_CBE
59.99
31%
6
- C2 -
-
1KBI
3
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N
T---------
K
T
-----------
N
V
E
E
S
----
Q
G
---
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
62
PsiBlast_CBE
59.54
31%
5
- C2 -
-
1SZE
2
CYB2_YEAST
A:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
---------------------------------------
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
69
PsiBlast_CBE
59.20
31%
6
- C2 -
-
1SZF
2
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-------------------------------------------
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
70
PsiBlast_CBE
58.73
31%
15
- C2 -
-
1SZF
2
CYB2_YEAST
A:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
G
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
N---------------------------------
G
---
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
71
PsiBlast_CBE
56.86
31%
19
- C2 -
-
2OZ0
2
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDKQ
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
SN---------------------------------
G
---
A
-
S
R
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
Q
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------
61
PsiBlast_CBE
54.58
31%
8
- C2 -
-
1SZE
2
CYB2_YEAST
B:
[121-474]
------------
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
-
G
E
K
D
V
A
R
G
C
G
Q
---
G
V
T
K
V
P
Q
M
I
S
T
A
A
S
C
S
P
E
E
I
I
E
--
A
A
P
SDK
Q
I
Q
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
-------------------------------------------
A
L
-
S
----
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
-----
Q
R
NLKDK
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
-----------------------