@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0666: (2017-12-27 )
MSIIEMRDVVKKYDNGTTALRGVSVSVQPGEFAYIVGPSGAGKSTFIRSLYREVKIDKGSLSVAGFNLVKIKKKDVPLLRRSVGVVFQDYKLLPKKTVYENIAYAMEVIGENRRNIKRRVMEVLDLVGLKHKVRSFPNELSGGEQQRIAIARAIVNNPKVLIADEPTGNLDPDNSWEIMNLLERINLQGTTILMATHNSQIVNTLRHRVIAIENGRVVRDESKGEYGYDD
Atome Classification :
(22 SA)
.........--10..---...---.---.---.20........30........40........50........60........70.--.......80..-.......90........100.------..-....110.......120.......130....-...-----------140.......150.......160.......170.----......180....-.-.-.190.......200....--...210.......220..---.....230---------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
I
I
E
M
R
D
V
--
V
K
K
Y---DNG---T---
T
---
A
L
R
G
V
S
V
S
VQPG
E
F
A
Y
I
VGPSGA
G
K
S
T
F
I
R
S
L
Y
R
E
VKIDKG
S
L
S
V
A
G
F
N
L
V
K
I
K--KK
D
V
P
L
L
R
-
R
S
-
V
G
V
V
F
Q
D
Y
KLL
P
K
K
T
V
Y
E
N
I
A
------
Y
A
-
M
E
V
I
GE
N
R
R
N
I
K
R
R
V
M
E
V
L
D
L
VG
L
K
H
K
V
R
SF-
P
N
E-----------LSGG
E
Q
Q
R
I
A
I
A
R
A
IVNNP
K
V
L
I
A
DEPTGNLDPD----N
S
W
E
I
M
N
L
L
E
RIN-L-Q-G
T
T
I
L
M
ATH
N
S
Q
I
V
N
T
L
R
--
H
R
V
I
A
IEN
G
R
V
V
RDESKG---EYGYDD-----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.54
38%
-6
- C1 -
-
3TUI
1
METN_ECOLI
C:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.53
34%
-101
- C1 -
-
2IT1
-
?
A:
[1-223]
M
V
E
I
K
L
E
N
I
--
V
K
K
F
---
G
N
----
F
---
T
---
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
P
--
P
K
D
------
R
N
-
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
------
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
-
P
W
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
----
L
R
L
E
V
R
A
E
L
K
R
L
Q
-
K
-
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
--
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
---
E
V
Y
Y
-------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.47
38%
-7
- C1 -
-
3TUZ
1
METN_ECOLI
D:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.91
38%
-16
- C1 -
-
3TUI
1
METN_ECOLI
H:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.69
38%
-4
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.12
35%
0
- C- -
-
5NIL
-
?
J:
[4-243]
--
L
L
E
L
K
D
I
--
R
R
S
Y
PAG
D
E
Q
---
V
---
E
---
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
Q
D
V
A
T
L
D
--
A
D
A
L
A
Q
L
R
-
R
E
H
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
E
------
V
P
-
A
V
Y
A
G
L
E
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
R
L
G
L
E
D
R
T
E
Y
Y
-
P
A
Q
-----------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
----
S
G
E
E
V
M
A
I
L
H
Q
L
R
-
D
-
R
-
G
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
Q
-
A
--
E
R
V
I
E
I
R
D
G
E
I
V
R
N
------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.12
35%
0
- C- -
-
5NIK
-
?
J:
[4-243]
--
L
L
E
L
K
D
I
--
R
R
S
Y
PAG
D
E
Q
---
V
---
E
---
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
Q
D
V
A
T
L
D
--
A
D
A
L
A
Q
L
R
-
R
E
H
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
E
------
V
P
-
A
V
Y
A
G
L
E
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
R
L
G
L
E
D
R
T
E
Y
Y
-
P
A
Q
-----------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
----
S
G
E
E
V
M
A
I
L
H
Q
L
R
-
D
-
R
-
G
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
Q
-
A
--
E
R
V
I
E
I
R
D
G
E
I
V
R
N
------------------------------------------------------------------------------------------------------------------------
163
HHSearch
76.94
34%
-120
* C1 *
-
4YER
2
?
A:
[4-252]
-
D
I
I
V
V
E
N
L
--
V
K
K
F
---
G
D
----
F
---
E
---
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
H
D
V
L
K
E
------
P
R
E
V
R
-
R
K
-
I
G
I
V
F
Q
D
Q
S
L
D
R
E
L
T
A
Y
E
N
M
Y
------
I
H
-
G
K
I
Y
G
Y
G
G
E
K
L
K
K
R
I
L
E
L
L
E
F
V
E
L
L
E
F
K
D
K
P
-
V
K
T
-----------
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
----
T
R
A
H
M
W
E
Y
I
S
K
M
K
-
K
E
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
--
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
---
E
L
---------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
76.70
38%
-8
- C1 -
-
3TUI
1
METN_ECOLI
D:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.57
38%
-7
- C1 -
-
3TUJ
-
METN_ECOLI
C:
[2-227]
---
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
76.32
35%
-74
- C1 -
-
2YYZ
1
?
A:
[9-219]
-----------
L
K
K
Y
---
F
G
K
---
V
---
K
---
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
---
F
D
D
V
L
V
N
----
D
I
P
P
K
Y
-
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
------
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
-
P
T
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
------
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
--
S
R
I
A
V
F
N
Q
G
K
L
V
---------
Q
Y
G
T
P
D
-----------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
75.36
35%
-43
- C1 -
-
4YMV
1
?
A:
[1-225]
--
M
I
F
V
N
D
V
--
Y
K
N
F
---
G
S
----
L
---
E
---
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
---
V
K
I
N
NG
K
V
N
I
N
K
V
R
-
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
K
E
V
L
N
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
--
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
---
E
I
F
Y
-------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.33
38%
-15
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
146
Fugue
75.05
37%
-14
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
-
H
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
TRT
I
---
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
V
F
S
H
P
KTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
22
PsiBlast_CBE
75.00
38%
-10
- C1 -
-
3TUZ
1
METN_ECOLI
G:
[24-250]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
----------------------------------------------------------------------------------------------------------------
158
HHSearch
74.50
30%
-111
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-226]
-
A
A
L
H
I
G
H
L
--
S
K
S
F
---
Q
N
----
T
---
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
---
T
N
L
P
V
R
E
-
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
------
Y
G
-
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
G
R
Y
-
P
H
E
-----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
----
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
--
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
---
E
L
---------------------------------------------------------------------------------------------------------------
157
HHSearch
74.22
39%
-6
- C1 -
-
3DHW
-
METN_ECOLI
C:
[1-228]
--
M
I
K
L
S
N
I
--
T
K
V
F
---
H
Q
G
TRT
I
---
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
--
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------
L
P
-
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
-----------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
----
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
---
E
V
---------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.04
37%
-6
- C1 -
-
2OUK
-
?
A:
[22-248]
---
L
Q
M
I
D
V
H
Q
L
K
K
S
---
F
G
S
---
L
---
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
--
D
T
N
L
N
K
V
R
-
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
--
D
R
V
L
F
M
D
G
G
Y
I
I
-
E
E
G
K
P
---
E
D
L
F
D
------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.62
41%
-48
- C1 -
-
2PCL
5
LOLD_AQUAE
A:
[10-218]
-----------
I
K
K
V
---
I
R
G
---
Y
---
E
---
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
--
E
K
E
L
S
L
L
R
N
R
K
-
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
------
V
P
-
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
L
S
R
K
-
P
Y
E
-----------
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
----
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
-
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
--
H
R
T
L
E
M
K
D
G
K
V
V
--------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.41
34%
-126
- C1 -
-
4TQU
-
?
S:
[5-213]
---
V
S
I
Q
N
V
--
V
K
R
Y
---
D
K
----
T
---
T
---
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
N
D
L
A
--
P
K
D
------
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
------
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
K
-
P
S
D
-----------
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
----
L
R
T
Q
M
R
A
E
I
K
R
L
H
-
Q
-
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
--
D
R
I
V
V
M
R
D
G
L
I
---------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
67.62
34%
37
- C1 -
-
3TIF
4
Y796_METJA
B:
[1-232]
--
M
V
K
L
K
N
V
--
T
K
T
Y
---
K
M
G
---
E
---
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
--
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
LPLIFK
Y
R
-
G
A
M
S
G
E
E
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
----
T
G
E
K
I
M
Q
L
L
K
K
L
N
-
E
-
E
D
G
K
T
V
V
V
V
T
H
D
---
I
N
V
A
R
FG
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
-----
R
G
F
-------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
48.64
33%
-35
- C1 -
-
4AYX
1
ABCBA_HUMAN
A:
[364-563]
-------------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
---
I
R
--
Q
L
N
P
V
W
L
R
-
S
K
-
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
------
Y
G
-
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
---
I
R
N
F
-
P
Q
G
FN
T
V
V
G
EK
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
----
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
-
D
-
G
R
T
V
L
V
----------
I
A
--
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
KIT
E
Y
G
--------------------------------------------------------------------------------------------------------------