@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0670: (2017-12-27 )
MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRVVNYVGGTDKARQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIAGSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKNAQIYQLTQLMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLYQPSDDSDIRELEKLGIKFSPKMVKDGEFQDTYDRDRRANREKKQDKLDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRAERKAKRQTF
Atome Classification :
(33 SA)
.........10........20........30......--..40........50........60..---------..----..------------------..70.----------------.......80.......----.90...-...--..100.......110.......120.......130...-....140......--..150.......160.......170.----.----.-------...-----.180........190.......200----.......210--.........220...-.-.----.-.230.---.....-..-240........250.......260...---....270.......280.......290.......300.......310.......320.......330.......340.......350.....-..360.......370.......380.......390.......400.......410.......420.......430.......440.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
F
T
K
F
Q
F
K
N
Y
I
R
E
A
L
K
ELKFTTPTEVQD
K
L
I
P
I
V
LA--GRDLVGESKTGSGK
T
H
T
F
L
L
P
I
F
Q
Q
L
---------
D
E
----AS------------------DS
V
Q
A
----------------
V
I
TAP
S
R
E
L
A
T
Q
I
Y
Q
V
----
A
R
Q
ISA-HS
D
--
V
E
V
R
V
V
N
YVGG
T
D
K
A
R
Q
I
E
K
LESNQP
H
I
V
IGTP
G
R
I
Y
D
-
L
VKSG-
D
L
A
I
H
K
A
--
K
T
F
V
V
DEAD
M
T
L
D
M
G
F
L
E
T
V
D
K
I
A
GS----L----P-------KD
L
-----
Q
F
-
M
V
F
SATI
P
Q
K
L
Q
P
F
L
K
K
Y
LS
N
P
----
V
M
E
K
I
K
T
K
----
T
V
I
S
D
TID
N
W
L
I
STK-G-H----D-KN-
A
Q
---
I
Y
Q
L
T
-
Q
L
-
M
-
Q
P
Y
L
A
M
I
F
VNTKT
R
A
D
E
L
H
S
Y
L
T
AQ---G
L
K
V
A
K
IHGDIA
P
R
E
R
K
R
I
M
N
Q
V
QNL
D
F
E
Y
I
V
ATDLAARGI
D
I
E
G
V
S
H
V
I
N
DAI
P
Q
D
L
S
F
F
V
H
R
VGRTGRNGLPG
T
A
I
T
L
YQPSD
D
S
D
I
R
E
L
-
E
K
LGIKFSPKMVKDGEFQ
D
T
Y
D
R
D
R
RA
N
R
E
K
K
Q
DKL
D
I
E
M
I
G
L
V
K
K
K
K
K
KVKPGY
K
K
K
I
Q
W
A
V
D
E
K
R
R
K
T
K
R
A
E
N
R
AR
G
R
A
E
R
KAKRQTF
1
PsiBlast_PDB
85.40
36%
-107
- C3 -
-
5IVL
-
?
B:
[4-360]
--
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
--
N
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
---------
D
V
----
K
N
------------------
G
A
I
Q
A
----------------
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
----
L
Y
K
I
G
A
-
V
K
----
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
A
L
K
K
H
-
P
H
V
I
V
G
T
P
G
R
I
I
D
-
H
I
N
R
G
-
T
L
R
L
E
H
V
--
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
E
D
I
E
A
I
L
S
H
----
V
----
P
-------
A
E
R
-----
Q
T
-
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
----
E
L
V
K
V
K
A
--------
V
P
N
I
Q
Q
Y
Y
L
E
V
H
-
E
-
K
----
K
-
K
F
-
D
I
---
L
T
R
L
L
-
D
I
-
Q
-
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
---
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
I
G
Q
L
H
H
I
-
E
R
----------------------------------------------------------------------------------------
113
HHSearch
84.44
36%
-107
- C3 -
-
5IVL
-
?
B:
[4-359]
--
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
--
N
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
---------
D
V
----
K
N
------------------
G
A
I
Q
A
----------------
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
----
L
Y
K
I
G
A
-
V
K
----
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
R
Q
I
R
A
L
-
K
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
-
H
I
N
R
G
-
T
L
R
L
E
H
V
--
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
E
D
I
E
A
I
L
S
H
----
V
----
P
-------
A
E
R
-----
Q
T
-
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
----
E
L
V
K
V
K
A
--------
V
P
N
I
Q
Q
Y
Y
L
E
V
H
-
E
-
K
----
K
-
K
F
-
D
I
---
L
T
R
L
L
-
D
I
-
Q
-
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
---
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
I
G
Q
L
H
H
I
-
E
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.43
32%
-87
- C3 -
-
5ANR
-
DDX6_HUMAN
B:
[98-459]
--
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
---------
D
L
----
K
K
------------------
D
N
I
Q
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
----
C
I
Q
V
S
K
-
H
M
G
---
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
-
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
G
-
V
A
K
V
D
H
V
--
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
-------
K
N
R
-----
Q
I
-
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
YEIN
L
M
E
E
L
T
L
K
----
G
V
-----
T
Q
Y
Y
A
Y
V
T
-
E
-
R
----
Q
-
K
V
-
H
C
---
L
N
T
L
F
-
S
R
-
L
-
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
D
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
---------------------------------------------------------------------------------
123
HHSearch
80.04
32%
-137
- C3 -
-
4CT4
-
DDX6_HUMAN
B:
[6-360]
-
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
---------
D
L
----
K
K
------------------
D
N
I
Q
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
----
C
I
Q
V
S
K
-
H
M
G
---
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
G
-
V
A
K
V
D
H
V
--
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
-------
K
N
R
-----
Q
I
-
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
----
Y
E
I
N
L
M
E
E
-----
L
T
L
K
G
V
T
Q
Y
Y
A
Y
V
T
-
E
-
R
----
Q
-
K
V
-
H
C
---
L
N
T
L
F
-
S
R
-
L
-
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
F
N
L
K
S
I
-
E
E
----------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.55
32%
-85
- C3 -
-
4CT4
-
DDX6_HUMAN
B:
[7-368]
--
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
---------
D
L
----
K
K
------------------
D
N
I
Q
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
----
C
I
Q
V
S
K
-
H
M
G
---
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
-
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
G
-
V
A
K
V
D
H
V
--
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
-------
K
N
R
-----
Q
I
-
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
YEIN
L
M
E
E
L
T
L
K
----
G
V
-----
T
Q
Y
Y
A
Y
V
T
-
E
-
R
----
Q
-
K
V
-
H
C
---
L
N
T
L
F
-
S
R
-
L
-
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
---------------------------------------------------------------------------------
15
PsiBlast_PDB
78.34
31%
-63
- C3 -
-
3EX7
3
IF4A3_HUMAN
C:
[58-394]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
EW
K
F
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.63
32%
-86
- C3 -
-
4CT5
-
DDX6_HUMAN
A:
[7-368]
--
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
---------
D
L
----
K
K
------------------
D
N
I
Q
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
----
C
I
Q
V
S
K
-
H
M
G
---
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
-
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
G
-
V
A
K
V
D
H
V
--
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
E
D
I
I
L
T
----
L
----
P
-------
K
N
R
-----
Q
I
-
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
L
T
L
K
----
G
V
-----
T
Q
Y
Y
A
Y
V
T
-
E
-
R
----
Q
-
K
V
-
H
C
---
L
N
T
L
F
-
S
R
-
L
-
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
---------------------------------------------------------------------------------
124
HHSearch
77.49
30%
-129
- C3 -
-
1S2M
-
DHH1_YEAST
A:
[46-400]
N
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
---------
K
P
----
K
L
------------------
N
K
I
Q
A
----------------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
----
V
R
T
L
G
K
-
H
C
----
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
K
-
V
A
D
L
S
D
C
--
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
T
I
I
E
Q
I
L
S
F
----
L
----
P
-------
P
T
H
-----
Q
S
-
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
----
Y
E
I
N
L
M
E
E
-----
L
T
L
K
G
I
T
Q
Y
Y
A
F
V
E
-
E
-
R
----
Q
-
K
L
-
H
C
---
L
N
T
L
F
-
S
K
-
L
-
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
-
E
Q
----------------------------------------------------------------------------------------
125
HHSearch
75.93
32%
-98
- C3 -
-
1FUU
-
IF4A_YEAST
B:
[22-375]
-
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---------
D
T
----
S
V
------------------
K
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
----
V
M
A
L
A
F
-
H
M
----
D
I
K
V
H
A
C
I
G
G
T
S
F
V
E
D
A
E
G
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
-------
P
T
T
-----
Q
V
-
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
E
-
E
----
Y
-
K
Y
-
E
C
---
L
T
D
L
Y
-
D
S
-
I
-
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
G
G
----
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
-
E
-----------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.79
31%
-59
- C3 -
-
2J0S
2
IF4A3_HUMAN
A:
[57-393]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
E
W
K
F
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.53
31%
-58
- C3 -
-
2HYI
2
IF4A3_HUMAN
I:
[58-394]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
EWKF
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.35
31%
-58
- C3 -
-
2J0Q
2
IF4A3_HUMAN
B:
[57-393]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
EWKF
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.32
31%
-60
- C3 -
-
3EX7
3
IF4A3_HUMAN
H:
[58-394]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
EWKF
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
45
PsiBlast_CBE
75.13
33%
-93
- C3 -
-
2VSO
1
IF4A_YEAST
B:
[42-378]
--------------------
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---------
D
T
----
S
V
------------------
K
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
----
V
M
A
L
A
F
-
H
M
D
--
I
K
V
H
A
C
--
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
-------
P
T
T
-----
Q
V
-
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
----
E
Y
K
Y
-
E
C
---
L
T
D
L
Y
-
D
S
-
I
-
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
-
E
K
F
---------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.97
31%
-61
- C3 -
-
2XB2
1
IF4A3_HUMAN
X:
[58-394]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
EWKF
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
43
PsiBlast_CBE
74.83
33%
-91
- C3 -
-
2VSX
1
IF4A_YEAST
B:
[42-378]
--------------------
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---------
D
T
----
S
V
------------------
K
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
----
V
M
A
L
A
F
-
H
M
D
--
I
K
V
H
A
C
--
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
-------
P
T
T
-----
Q
V
-
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
----
E
Y
K
Y
-
E
C
---
L
T
D
L
Y
-
D
S
-
I
-
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
-
E
K
F
---------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.67
31%
-58
- C3 -
-
2J0Q
2
IF4A3_HUMAN
A:
[57-393]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
E
W
K
F
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
44
PsiBlast_CBE
74.65
33%
-91
- C3 -
-
2VSX
1
IF4A_YEAST
A:
[42-378]
--------------------
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---------
D
T
----
S
V
------------------
K
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
----
V
M
A
L
A
F
-
H
M
D
--
I
K
V
H
A
C
--
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
-------
P
T
T
-----
Q
V
-
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
----
E
Y
K
Y
-
E
C
---
L
T
D
L
Y
-
D
S
-
I
-
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
-
E
K
F
---------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.51
31%
-61
- C3 -
-
2HYI
2
IF4A3_HUMAN
C:
[58-394]
--------------------
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
---------
D
I
----
Q
V
------------------
R
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
----
L
L
A
L
G
D
-
Y
M
N
--
V
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
----
L
----
P
-------
P
A
T
-----
Q
V
-
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
E
W
K
F
D
-
T
L
-
C
D
---
L
Y
D
T
L
-
T
I
-
T
-
Q
---
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
D
I
-
E
Q
----------------------------------------------------------------------------------------
46
PsiBlast_CBE
74.50
33%
-92
- C3 -
-
2VSO
1
IF4A_YEAST
A:
[42-378]
--------------------
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---------
D
T
----
S
V
------------------
K
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
----
V
M
A
L
A
F
-
H
M
D
--
I
K
V
H
A
C
--
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
G
F
K
E
Q
I
Y
Q
I
F
T
L
----
L
----
P
-------
P
T
T
-----
Q
V
-
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
----
E
Y
K
Y
-
E
C
---
L
T
D
L
Y
-
D
S
-
I
-
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
L
-
E
K
F
---------------------------------------------------------------------------------------
130
HHSearch
73.45
35%
1
- C3 -
-
2I4I
1
DDX3X_HUMAN
A:
[16-393]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
---------
Y
S
----
D
G
PG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
----------------
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
----
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
----
D
TMPP
K
-------
G
V
R
-----
H
T
-
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
--------
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
----
D
-
K
R
-
S
F
---
L
L
D
L
L
-
N
A
T
G
-
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
I
N
I
T
K
D
L
-
L
D
----------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.01
34%
-5
- C3 -
-
5E7J
1
DDX3X_HUMAN
A:
[49-414]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
-------
D
G
----
P
G
------------------
E
A
L
R
A
M
KKQYPI
S
--------
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
R
--
V
R
P
C
V
V
--
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DTM-
P
----
P
-------
K
G
V
-----
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
R
V
----
G
S
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
----
D
-
K
R
-
S
F
---
L
L
D
L
L
-
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
-----------------------------------------------------------------------------------------------------
118
HHSearch
71.91
33%
-5
- C3 -
-
4D25
3
?
A:
[51-410]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
---------
L
Q
----
D
P
KD
L
I
S
E
NG
C
---------
A
Q
P
Q
V
----------------
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
----
A
R
K
F
S
Y
-
G
S
----
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
N
-
R
V
S
F
G
S
V
--
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
PTMV
E
----
T
-------
T
K
R
-----
Q
T
-
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
----
L
F
V
A
V
G
I
V
----
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
-
K
-
Y
----
E
-
K
R
-
N
S
---
L
K
Q
L
I
-
E
E
-
N
-
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
D
-------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.55
32%
-10
- C3 -
-
4D25
3
?
A:
[51-410]
-
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
PKD
L
I
S
E
N
----
G
C
------------------
A
Q
P
Q
V
----------------
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
----
A
R
K
F
S
Y
-
G
S
V
--
L
K
V
A
V
A
--
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
N
-
R
V
S
F
G
S
V
--
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
P
S
I
E
K
M
M
L
H
---------
P
-------
T
M
V
ETTK
R
Q
T
-
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
----
L
F
V
A
V
G
I
V
----
G
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
-
K
-
Y
----
E
-
K
R
-
N
S
---
L
K
Q
L
I
-
E
E
-
N
-
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
D
-------------------------------------------------------------------------------------------------
112
HHSearch
70.44
31%
5
- C3 -
-
3I5X
2
MS116_YEAST
A:
[74-458]
--
L
E
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
---------
I
N
----
T
K
FDSQ--------------
Y
M
V
K
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
----
V
K
K
I
H
D
-
M
N
Y
GL
K
K
Y
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
Y
S
N
K
F
F
R
F
V
--
D
Y
K
V
L
D
E
A
D
R
L
L
E
I
G
F
R
D
D
L
E
T
I
S
G
I
----
L
----
N
E
K
NSKSA
D
N
I
-----
K
T
-
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
----
E
C
L
F
L
D
T
V
DKNE
P
E
A
H
E
R
I
D
Q
S
V
V
I
S
E
-
K
F
A
----
N
-
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
-
D
-
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
-
E
-----------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.80
34%
1
- C3 -
-
2I4I
1
DDX3X_HUMAN
A:
[16-381]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
-------
D
G
----
P
G
------------------
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
R
--
V
R
P
C
V
V
--
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DTM-
P
----
P
-------
K
G
V
-----
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
--------
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
----
D
-
K
R
-
S
F
---
L
L
D
L
L
-
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
-----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.38
34%
-2
- C3 -
-
5E7M
1
DDX3X_HUMAN
A:
[49-414]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
-------
D
G
----
P
G
------------------
E
A
L
R
A
M
KR
R
K
Q
Y
P
I
S
------
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
R
--
V
R
P
C
V
V
--
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DTM-
P
----
P
-------
K
G
V
-----
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
R
V
----
G
S
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
----
D
-
K
R
-
S
F
---
L
L
D
L
L
-
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
-----------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
51.15
38%
-43
- C3 -
-
3BER
3
DDX47_HUMAN
A:
[44-243]
-
T
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
--
G
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
L
---------
L
E
----
T
P
------------------
Q
R
L
F
A
----------------
L
V
L
T
P
T
R
E
L
A
---
F
Q
I
----
S
E
Q
F
E
A
L
G
S
S
--
I
G
V
Q
S
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
K
P
H
I
I
I
A
T
P
G
R
L
I
D
H
L
E
N
T
K
-
G
F
N
L
R
A
L
--
K
Y
L
V
M
D
E
A
D
R
I
L
N
M
D
F
E
T
E
V
D
K
I
L
K
V
----
I
----
P
-------
R
D
R
-----
K
T
-
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
----
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
49.02
32%
-33
- C3 -
-
5GVR
1
DDX41_HUMAN
A:
[14-226]
-
S
F
K
E
M
K
F
P
A
A
I
L
R
G
L
K
K
K
G
I
H
H
P
T
P
I
Q
I
Q
G
I
P
T
I
L
S
--
G
R
D
M
I
G
I
A
F
T
G
S
G
K
T
L
V
F
T
L
P
V
I
M
F
C
---------
L
E
----
Q
E
K
R
LPFSKR----------
E
G
P
Y
G
----------------
L
I
I
C
P
S
R
E
L
A
R
Q
T
H
G
I
L
E
Y
Y
C
R
L
L
Q
E
-
D
S
S
--
P
L
L
R
C
A
L
C
I
G
G
M
S
V
K
E
Q
M
E
T
I
R
H
G
V
-
H
M
M
V
A
T
P
G
R
L
M
D
-
L
L
Q
K
K
-
M
V
S
L
D
I
C
--
R
Y
L
A
L
D
E
A
D
R
M
I
D
M
G
F
E
G
D
I
R
T
I
F
S
Y
----
F
----
K
-------
G
Q
R
-----
Q
T
-
L
L
F
S
A
T
M
P
K
K
I
Q
N
F
A
K
S
A
L
V
K
P
----
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
48.10
36%
-29
- C3 -
-
4PX9
1
DDX3X_HUMAN
C:
[66-282]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
YS-------
D
G
----
P
G
------------------
E
A
L
R
A
MKENGRYGRRKQYPIS
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
R
--
V
R
P
C
V
V
--
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DTM-
P
----
P
-------
K
G
V
-----
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
48.09
36%
-29
- C3 -
-
4PX9
1
DDX3X_HUMAN
A:
[66-282]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
-------
D
G
----
P
G
------------------
E
A
L
R
A
MKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
R
--
V
R
P
C
V
V
--
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DTM-
P
----
P
-------
K
G
V
-----
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
47.53
36%
-28
- C3 -
-
4PX9
1
DDX3X_HUMAN
B:
[66-282]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
-------
D
G
----
P
G
------------------
E
A
L
R
A
MKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
----
A
R
K
F
S
Y
-
R
S
R
--
V
R
P
C
V
V
--
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
P
Q
I
R
R
I
V
E
Q
DTM-
P
----
P
-------
K
G
V
-----
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
43.60
32%
-8
- C3 -
-
2PL3
4
DDX10_HUMAN
A:
[27-227]
--
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
---------
Y
R
L
QWT
S
T
------------------
D
G
L
G
V
----------------
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
----
L
R
K
V
G
K
-
N
H
D
--
F
S
A
G
L
I
--
I
G
G
--
L
K
H
E
A
E
R
I
--
N
N
I
N
I
L
V
C
T
P
G
R
L
L
Q
-
H
M
D
E
--
T
V
S
F
H
A
T
DL
Q
M
L
V
L
D
E
A
D
R
I
L
D
M
G
F
A
D
T
M
N
A
V
I
E
N
----
L
----
P
-------
K
K
R
-----
Q
T
-
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------