@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0671: (2017-12-27 )
MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSPDIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRLAELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDKVIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVAESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALKEAVK
Atome Classification :
(38 SA)
....-.....10........20........30........40........50........60.---.......70........80........90........100.......110.......120.......130.......140.......150.......160.....---..170.......180...-..---.---.----190.......200----.....-..-210.......220.....---.-.230-........240.......250.......260.......270.......280.......290.......300.......310.......320.......330--.......340.......350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSER-KLFTSESVSEGH
P
D
K
I
A
D
Q
I
S
D
A
I
L
D
A
I
L
AKDPEA
H
V
A
A
E
T
A
V
Y
TG
S
V
H
V
F
G
EIST
N
A
---
Y
V
D
I
N
R
V
V
R
D
T
I
A
E
IGYTNTEYGFSAETVGV
H
P
S
L
V
EQSP
D
I
A
Q
G
V
N
E
A
L
E
VRGNADQD
P
L
D
LIGAGDQ
G
L
M
F
G
F
AVDETEELMPL
P
I
A
L
S
H
K
L
V
R
R
L
A
E
L
R
KSG---E
I
S
Y
LRPDAK
S
Q
V
T
V
E
YD-EN---D---R----
P
V
R
V
D
T
V
V
I
STQH----DPEA
T
-
N
E
-
Q
I
H
Q
D
V
I
D
K
V
I
K
E
VI
P
S
S---Y-LD-D-K
T
K
F
F
INPTG
R
F
V
I
GGPQGDSGLTG
R
K
I
I
V
DTYGGYSRHGGGAFSGKDATKVD
R
S
A
S
Y
A
A
R
Y
I
A
K
N
I
V
A
A
GLAK
K
A
E
V
Q
L
A
Y
A
IGVAQ
P
V
S
V
R
I
D
TFGTG
T
--
V
A
E
S
Q
L
E
K
A
A
R
Q
I
FDLRP
A
G
I
I
Q
M
LDLKR
P
I
Y
R
QTSAYGHMGRTDIDL
P
W
E
R
L
D
K
V
D
A
L
K
E
AVK
25
PsiBlast_CBE
80.60
59%
-63
- C3 -
-
1P7L
2
METK_ECOLI
D:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
22
PsiBlast_CBE
80.30
59%
-63
- C3 -
-
1RG9
2
METK_ECOLI
D:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
23
PsiBlast_CBE
79.83
59%
-63
- C3 -
-
1RG9
2
METK_ECOLI
C:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
4
PsiBlast_PDB
79.66
59%
-61
- C3 -
-
1P7L
2
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
26
PsiBlast_CBE
79.59
59%
-61
- C3 -
-
1P7L
2
METK_ECOLI
C:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
5
PsiBlast_PDB
79.44
59%
-61
- C3 -
-
1RG9
2
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
82
HHSearch
79.33
61%
-62
- C3 -
-
1RG9
2
METK_ECOLI
A:
[2-380]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
D
----------
P
L
E
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
----
G
---
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
-
8
PsiBlast_PDB
79.11
59%
-67
- C3 -
-
1MXC
1
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
27
PsiBlast_CBE
78.94
59%
-62
- C3 -
-
1P7L
2
METK_ECOLI
B:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
24
PsiBlast_CBE
78.74
59%
-61
- C3 -
-
1RG9
2
METK_ECOLI
B:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
6
PsiBlast_PDB
78.61
59%
-64
- C3 -
-
1MXA
1
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
7
PsiBlast_PDB
78.46
59%
-66
- C3 -
-
1MXB
1
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
10
PsiBlast_PDB
77.66
59%
-65
- C3 -
-
1XRC
-
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
9
PsiBlast_PDB
77.64
59%
-63
- C3 -
-
1XRA
-
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
16
PsiBlast_PDB
77.63
58%
-67
- C3 -
-
1XRB
-
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
------
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
74
HHSearch
77.24
61%
-22
- C3 -
-
5H9U
-
METK_THET2
A:
[19-412]
M
R
A
L
-
R
L
V
T
S
E
S
V
T
E
G
H
P
D
K
L
A
D
R
I
S
D
A
I
L
D
A
L
I
A
Q
D
K
K
A
R
V
A
A
E
T
L
V
T
T
G
L
V
F
V
A
G
E
I
T
T
E
G
---
Y
V
D
I
P
N
L
V
R
K
T
V
R
E
V
G
Y
T
R
A
K
Y
G
F
D
A
D
T
C
A
V
L
T
A
I
D
E
Q
S
P
D
I
A
G
G
V
N
L
S
Y
E
W
R
V
L
K
S
T
D
P
L
D
R
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
P
E
L
M
P
L
P
I
T
L
A
H
R
L
T
M
R
L
A
E
V
R
K
T
G
---
L
L
P
Y
L
R
P
D
G
K
A
Q
V
T
V
V
Y
E
-
G
----
D
---
K
----
P
L
Y
V
K
T
V
V
V
S
A
Q
H
----
S
P
E
V
E
-
Q
E
-
Q
L
R
E
D
L
I
R
E
V
V
R
Q
A
I
P
P
E
---
Y
L
K
D
-
G
-
E
T
E
Y
L
I
N
P
S
G
R
F
I
L
G
G
P
H
A
D
T
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
V
P
H
G
G
G
A
F
S
G
K
D
P
T
K
V
D
R
S
A
S
Y
Y
A
R
Y
M
A
K
N
I
V
A
A
G
L
A
R
R
A
L
V
E
L
A
Y
A
I
G
K
A
R
P
V
S
L
R
V
E
T
F
G
T
G
V
--
L
P
D
E
K
L
T
E
I
A
K
K
V
F
D
P
R
P
L
A
I
I
E
E
L
D
L
L
R
P
I
Y
T
P
T
S
A
Y
G
H
F
G
R
P
--
G
F
P
W
E
E
T
D
R
V
E
A
L
R
R
E
A
G
1
PsiBlast_PDB
76.87
61%
-25
- C3 -
-
5H9U
-
METK_THET2
C:
[19-408]
M
R
A
L
-
R
L
V
T
S
E
S
V
T
E
G
H
P
D
K
L
A
D
R
I
S
D
A
I
L
D
A
L
I
A
Q
D
K
K
A
R
V
A
A
E
T
L
V
T
T
G
L
V
F
V
A
G
E
I
T
T
E
G
---
Y
V
D
I
P
N
L
V
R
K
T
V
R
E
V
G
Y
T
R
A
K
Y
G
F
D
A
D
T
C
A
V
L
T
A
I
D
E
Q
S
P
D
I
A
G
G
V
N
L
S
Y
E
W
R
V
L
K
S
T
D
P
L
D
R
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
P
E
L
M
P
L
P
I
T
L
A
H
R
L
T
M
R
L
A
E
V
R
K
T
G
---
L
L
P
Y
L
R
P
D
G
K
A
Q
V
T
V
V
Y
--
E
G
---
D
---
K
----
P
L
Y
V
K
T
V
V
V
S
A
Q
H
----
S
P
E
V
E
-
Q
E
-
Q
L
R
E
D
L
I
R
E
V
V
R
Q
A
I
P
P
E
---
Y
-
L
K
-
D
G
E
T
E
Y
L
I
N
P
S
G
R
F
I
L
G
G
P
H
A
D
T
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
V
P
H
G
G
G
A
F
S
G
K
D
P
T
K
V
D
R
S
A
S
Y
Y
A
R
Y
M
A
K
N
I
V
A
A
G
L
A
R
R
A
L
V
E
L
A
Y
A
I
G
K
A
R
P
V
S
L
R
V
E
T
F
G
T
G
V
--
L
P
D
E
K
L
T
E
I
A
K
K
V
F
D
P
R
P
L
A
I
I
E
E
L
D
L
L
R
P
I
Y
T
P
T
S
A
Y
G
H
F
G
R
P
--
G
F
P
W
E
E
T
D
R
V
E
A
L
R
----
3
PsiBlast_PDB
76.26
59%
-66
- C3 -
-
1FUG
-
METK_ECOLI
A:
[2-379]
---
K
-
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
---------
D
P
L
E
Q
-
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
N
G
---
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
-
D
G
-------
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
----
S
E
E
I
D
-
Q
K
-
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
A
E
---
W
-
L
T
-
S
-
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
--
15
PsiBlast_PDB
76.05
60%
-58
- C3 -
-
3IML
-
METK_BURPS
A:
[1-385]
M
A
N
D
-
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
I
S
D
A
I
L
D
A
I
L
A
Q
D
K
Y
S
R
V
A
A
E
T
L
C
N
T
G
L
V
V
L
A
G
E
I
T
T
T
A
---
N
I
D
Y
I
Q
I
A
R
D
T
I
K
R
I
G
Y
D
---------
G
C
A
V
L
V
A
Y
D
K
Q
S
P
--------------
N
L
D
Q
------
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
E
L
M
P
L
P
I
H
L
S
H
R
L
V
E
R
Q
A
N
L
R
R
D
G
---
R
L
P
W
L
R
P
D
A
K
S
Q
V
T
V
R
Y
V
-
D
G
-------
K
----
P
H
S
I
D
T
V
V
L
S
T
Q
H
----
A
P
E
I
D
-
L
P
-
A
L
R
E
A
V
I
E
E
V
I
K
P
T
L
P
A
D
---
L
-
I
K
-
G
-
D
I
K
F
L
V
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
G
R
Y
V
A
K
N
I
V
A
A
G
L
A
S
R
A
L
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
V
M
V
N
T
F
G
T
G
R
--
V
S
D
E
T
I
T
K
L
V
R
E
H
F
D
L
R
P
K
G
I
I
Q
M
L
D
L
L
R
P
I
Y
E
K
T
A
A
Y
G
H
F
G
R
E
E
P
E
F
S
W
E
A
A
D
K
A
L
A
L
A
E
A
--
43
PsiBlast_CBE
75.69
56%
-31
- C3 -
-
4KTT
1
METK2_HUMAN
D:
[20-389]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
--------
L
D
R
N
E
E
D
-
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
-
Q
----
D
---
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
-
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
-------------
52
PsiBlast_CBE
75.64
56%
-28
- C3 -
-
5A1I
3
METK2_HUMAN
A:
[19-388]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
--------
L
D
R
N
E
E
D
-
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
-
Q
----
D
---
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
-
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
-------------
30
PsiBlast_CBE
75.54
60%
-14
- C3 -
-
5T8T
1
METK_NEIG1
B:
[10-394]
-
S
E
Y
--
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
------------
D
L
N
Q
--------
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
S
E
T
---
G
---
K
----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
-
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
--
81
HHSearch
75.45
61%
-7
- C3 -
-
5T8S
3
METK_NEIG1
A:
[10-396]
--
S
E
-
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
D
I
A
Q
G
V
N
E
G
E
G
--------
I
D
L
N
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
-
S
E
T--
G
---
K
----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
-
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
A
G
31
PsiBlast_CBE
75.32
60%
-12
* C3 *
-
5T8S
3
METK_NEIG1
B:
[10-394]
-
S
E
Y
--
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
------------
D
L
N
Q
--------
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
S
E
T
---
G
---
K
----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
-
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
--
53
PsiBlast_CBE
75.14
56%
-30
- C3 -
-
5A1G
5
METK2_HUMAN
A:
[19-388]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
--------
L
D
R
N
E
E
D
-
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
-
Q
----
D
---
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
-
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
-------------
13
PsiBlast_PDB
74.79
60%
-6
- C3 -
-
5T8S
3
METK_NEIG1
A:
[10-394]
-
S
E
Y
--
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
V
S
D
A
I
L
D
A
I
L
A
Q
D
P
K
A
R
V
A
A
E
T
L
V
N
T
G
L
C
V
L
A
G
E
I
T
T
T
A
---
Q
V
D
Y
I
K
V
A
R
E
T
I
K
R
I
G
Y
N
S
S
E
L
G
F
D
A
N
G
C
A
V
G
V
Y
Y
D
Q
Q
S
P
D
I
A
Q
G
V
N
E
G
E
G
I
D
L
N
Q
--------
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
T
L
M
P
F
A
I
Y
Y
S
H
R
L
M
Q
R
Q
S
E
L
R
K
D
G
---
R
L
P
W
L
R
P
D
A
K
A
Q
L
T
V
V
Y
D
S
E
T
---
G
---
K
----
V
K
R
I
D
T
V
V
L
S
T
Q
H
----
D
P
A
I
S
-
Q
E
-
E
L
S
K
A
V
I
E
Q
I
I
K
P
V
L
P
P
E
---
L
-
L
T
-
D
-
E
T
K
Y
L
I
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
C
R
Y
V
A
K
N
I
V
A
A
G
L
A
T
Q
C
Q
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
S
I
D
T
F
G
T
G
K
--
I
S
E
E
K
L
I
A
L
V
C
E
H
F
D
L
R
P
K
G
I
V
Q
M
L
D
L
L
R
P
I
Y
G
K
S
A
A
Y
G
H
F
G
R
E
E
P
E
F
T
W
E
R
T
D
K
A
A
S
L
K
A
A
--
54
PsiBlast_CBE
73.88
56%
-30
- C3 -
-
5A19
7
METK2_HUMAN
A:
[19-388]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
-------------------
E
E
D
-
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
N
G
---
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
-
Q
----
D
---
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
----
D
E
E
V
C
-
L
D
-
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
-------------
17
PsiBlast_PDB
71.94
56%
-17
- C3 -
-
1QM4
1
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------------
E
D
-
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
-
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
-
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
-------------
18
PsiBlast_PDB
71.87
56%
-17
- C3 -
-
1O90
1
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------------
E
D
-
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
-
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
-
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
-------------
34
PsiBlast_CBE
71.78
56%
-15
- C3 -
-
1O9T
1
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------------
E
D
-
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
-
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
-
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
-------------
20
PsiBlast_PDB
71.71
56%
-16
- C3 -
-
1O93
2
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------------
E
D
-
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
-
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
-
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
-------------
79
HHSearch
71.59
52%
-14
- C3 -
-
4ODJ
1
?
A:
[29-413]
--
E
Q
-
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
H
V
D
K
---------
N
V
E
D
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
K
G
VSS
R
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
N
-
C
K
HG
V
L
---
I
----
P
K
R
I
H
T
I
L
V
S
V
Q
H
----
D
E
N
I
E
-
N
E
-
E
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
D
---
L
-
M
D
-
K
-
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
P
I
I
L
--------
19
PsiBlast_PDB
71.59
56%
-17
- C3 -
-
1O92
2
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------------
E
D
-
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
-
Q
D
---
N
---
G
A
V
I
-
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
-
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
-------------
61
PsiBlast_CBE
70.46
50%
-11
- C3 -
-
4ODJ
1
?
A:
[29-409]
--
E
Q
-
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
H
--------
V
D
K
N
V
E
D
-
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
K
G
VSS
R
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
N
-
C
K
---
H
---
G
V
L
I
-
P
K
R
I
H
T
I
L
V
S
V
Q
H
----
D
E
N
I
E
-
N
E
-
E
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
S
D
---
L
-
M
D
-
K
-
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
------------
76
HHSearch
68.03
60%
4
- C3 -
-
3S82
3
METK_MYCA1
B:
[6-407]
S
E
K
G
-
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
-
D
----
D
---
V
----
P
V
R
L
D
T
V
V
I
S
T
Q
H
----
A
A
D
I
D
-
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
AHD
T
-
L
D
T
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
-
75
HHSearch
67.70
60%
2
- C3 -
-
3S82
3
METK_MYCA1
A:
[9-407]
---
G
-
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
-
D
----
D
---
V
----
P
V
R
L
D
T
V
V
I
S
T
Q
H
----
A
A
D
I
D
-
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
AHD
T
-
L
D
T
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
-
21
PsiBlast_CBE
64.91
59%
32
- C3 -
-
3S82
3
METK_MYCA1
B:
[6-407]
-
S
E
K
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
--------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
N
G
---
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
--
E
D
---
D
---
V
----
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
ADI
D
L
E
N
T
L
T
P
-
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
---
L
-
D
T
-
S
-
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
-
68
Fugue
37.30
54%
16
- C3 -
-
1QM4
1
METK1_RAT
A:
[129-251]
-------------------------------------------------------------------------------------------------------------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
S
G
---
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
-
Q
D
---
N
G
A
V
I
----
P
V
R
V
H
T
I
V
I
S
V
Q
H
----
N
E
D
I
T
-
L
E
-
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
A
K
---
Y
-
L
D
-
E
-
D
T
I
Y
H
L
Q
P
S
G
R
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------