@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0676: (2017-12-27 )
MKPSIHSLAHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEEMTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLSVCVTTQVDCNIGCTFCASDLIKKQRDLNNGEIVAQIMLVQKYFAERGQDERVSHIVVMGIGEPFDNYNNVLNFVCTINDDKGMAIGARHITVSTSGLAHKIRNFADEGVQVNLAVSLHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDSVEQALELAELLKNIKKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGGNCVVRQEYGTDIDAACGQLRSNTMKRDRQKAVAEVNP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90-........-100.......-----110.......120..--------..-..-----.130--.........140...----------..-------..--150.-......160......----.----170.........180.-......190.......200-------.----.-......210.-......220.......230...-....240.......250.---.---.---....260.......270.......280.......290..-.....300.-----.------------.---....310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKP
S
I
H
S
L
A
H
Q
T
M
Q
E
W
V
L
E
Q
G
E
K
KF
R
A
D
Q
I
W
E
W
L
Y
R
K
R
V
Q
S
F
E
E
M
T
N
L
S
K
D
L
I
A
K
LND
Q
F
V
V
N
P
L
K
Q
R
I
V
Q
ESADG
T
V
K
Y
L
F
ELPD
G
M
L
I
E
-
T
V
L
M
R
QHY-G
L
S
V
C
V
T
T
Q
V
-----DCNI
G
C
T
F
C
A
S
D
L
I
K
--------
K
Q
-RD-----LN----
N
G
E
I
V
A
Q
I
M
L
V
Q
K
Y
F
----------
A
E-------RG--QDER-
V
S
H
I
V
V
M
GIGEPFDN----Y----N--N
V
L
N
F
V
C
T
INDDK-
G
M
A
I
G
A
R
H
I
T
VSTS
G
L
A
H
--------
K
----
I
-
R
N
FADEG
V
Q
V
-
N
L
A
V
S
L
HAP
N
N
E
L
R
S
S
I
M
K
I
NR-AF
P
I
E
K
L
F
A
A
I
E
Y
Y
I
ETT---N---
R
---
R
V
T
F
E
Y
I
M
LNEV
N
D
S
V
E
Q
A
L
E
L
A
E
L
L
K
N
I
K
KL
S
Y
V
N
L
IP-YNPVS
E
H
D
Q
-----Y------------S---R
S
P
K
E
R
V
L
A
F
Y
D
T
L
K
KKGG
N
C
V
V
R
QEYGT
D
I
D
A
A
C
G
Q
L
R
S
N
T
M
K
R
D
R
Q
K
A
VAEVNP
9
PsiBlast_CBE
97.23
37%
-36
- C3 -
-
3RF9
2
RLMN_ECOLI
B:
[17-368]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
C
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G
---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
----------
D
V
I
D
R
T
K
R
--------
14
HHSearch
97.12
38%
-43
- C3 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
-
D
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
C
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
----------
G
A
-------
A
K
VT
G
Q
R
P
-
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
NAN
Q
---
G
---
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
--
P
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
---------------------------
2
PsiBlast_PDB
96.43
37%
-39
- C3 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
C
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
---------------------------
1
PsiBlast_PDB
96.08
37%
-32
- C3 -
-
3RF9
1
RLMN_ECOLI
A:
[17-368]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
C
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
----------
D
V
I
D
R
T
K
R
--------
4
PsiBlast_PDB
94.82
36%
-24
- C3 -
-
5HR6
2
RLMN_ECOLI
A:
[18-368]
--
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
A
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
--------
37
Fugue
94.76
37%
-39
- C3 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
-
G
D
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
C
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
GA--------
A
K
-------
V
T
--
G
Q
R
P
-
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
ANQ
G
---
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
P
------
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
---------------------------
11
PsiBlast_CBE
94.29
36%
-38
- C3 -
-
4PL1
1
?
A:
[1-332]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
A
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
----------------------------
12
PsiBlast_CBE
94.15
36%
-25
- C3 -
-
5HR7
2
RLMN_ECOLI
A:
[17-368]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
-
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
A
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G
---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
--------
3
PsiBlast_PDB
94.05
36%
-26
- C3 -
-
5HR7
2
RLMN_ECOLI
B:
[17-368]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
-
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
A
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
--------
5
PsiBlast_PDB
93.25
36%
-26
- C3 -
-
4PL1
1
?
B:
[1-352]
-
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
A
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
--------
10
PsiBlast_CBE
91.70
36%
-23
- C3 -
-
5HR6
2
RLMN_ECOLI
B:
[18-368]
--
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
-
Q
R
V
E
-
T
V
Y
I
P
E
D
D
-
R
A
T
L
A
V
S
S
Q
V
-----
G
C
A
L
E
C
K
F
C
S
T
A
Q
Q
G
--------
F
N
-
R
N
-----
L
R
----
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G---------
A
A
-------
K
V
--
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
--
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
----
L
-
D
K
L
G
D
M
-
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
-
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
---
N
---
A
NQG
R
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
--
C
K
I
N
L
I
P
-
W
N
P
F
P
G
A
-
P
-----
Y
------------
G
---
R
S
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
--------
18
HHSearch
48.80
15%
-9
- C3 -
-
3C8F
3
PFLA_ECOLI
A:
[19-244]
------------------------------------------------------------------------------------------------------
G
I
R
F
I
T
F
F
Q
-----
G
C
L
M
R
C
L
Y
C
H
N
R
D
T
W
DTH-----
G
G
-
K
E
-----
V
T
----
V
E
D
L
M
K
E
V
V
T
Y
R
H
F
M
------------------------
N
A
S
-
G
G
G
V
T
A
S
G
-
G
E
A
I
L
Q
----
A
----
E
--
F
V
R
D
W
F
R
A
C
K
K
-
E
-
G
I
-----
H
T
C
L
D
T
N
G
F
V
R
--------
R
YDP
V
I
-
D
E
L
L
E
--
V
T
D
-
L
V
M
L
D
L
K
Q
M
N
D
E
I
H
Q
N
L
V
G
V
-----
S
N
H
R
T
L
E
F
A
K
Y
L
A
N
K
----
N
---
V
---
K
V
W
I
R
Y
V
V
V
P
G
W
S
D
D
D
D
S
A
H
R
L
G
E
F
T
R
D
M
G
N
V
E
K
I
E
L
L
P
-
Y
H
E
L
G
-
K
H
K
-----
W
V
A
M
GEEYKLDGV
K
---
P
P
K
K
E
T
M
E
R
V
K
G
I
L
E
Q
Y
G
H
K
V
M
----------------------------------
22
HHSearch
48.77
12%
-35
- C3 -
-
4U0P
3
LIPA2_THEEB
B:
[53-273]
------------------------------------------------------------------------------------------------------
T
A
T
F
L
L
L
G
P
-----
T
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
--------
A
P
-
A
A
-----
V
D
----
P
E
E
P
T
K
I
A
A
----
A
V
----------
A
T
-------------
L
G
-
L
R
Y
V
V
L
T
S
-
V
A
R
D
D
L
----
P
DQGA
G
--
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
G
T
-----
E
I
E
V
L
S
P
D
F
R
M
DRGRLSQR
D
C---
I
-
A
Q
I
V
A
A
-
Q
P
A
-
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
G
----
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P--
D
---
I
---
P
T
K
S
G
L
M
L
--
G
L
G
E
T
E
A
E
I
I
E
T
L
K
D
L
R
R
V
G
-
C
D
R
L
T
L
G
Q
-
Y
L
P
P
S
-
L
S
H
-----
L
------------
P
VVK
Y
W
T
P
E
E
F
N
T
L
G
N
I
A
R
E
L
G
F
S
H
-----------------------------------
38
Fugue
47.38
16%
-0
- C3 -
-
2YX0
-
TYW1_PYRHO
A:
[11-342]
-----------------------------------
K
I
T
V
Q
A
N
P
N
M
P
K
E
V
A
E
L
F
R
K
Q
H
Y
E
I
V
-----------
G
R
H
S
G
V
K
L
C
H
W
L
K
K
S
L
T
E
G
R
F
C
Y
K
Q
K
F
Y
-
G
I
H
S
H
R
C
L
Q
M
TPVLA
W
C
T
H
N
C
I
F
C
W
R
P
M
E
N
FLGTEL--
P
Q
-
P
W
-----
D
D
----
P
A
F
I
V
E
E
S
I
K
A
Q
R
K
L
L
I
GYKPKVDK
K
K
-------
F
E
--
E
A
W
N
-
P
T
H
A
A
I
S
L
S
G
E
P
M
L
-----
Y
----
P
--
Y
M
G
D
L
V
E
E
F
H
K
R
------
G
F
T
T
F
I
V
T
N
G
T
I
P
E
--------
R
----
L
-
E
E
M
I
K
E
D
K
L
P
T
Q
L
Y
V
S
I
T
A
P
D
I
E
T
Y
N
S
V
N
I
P
M
I
-
P
D
G
W
E
R
I
L
R
F
L
E
L
M
-
R
D
L
---
P
---
T
---
R
T
V
V
R
L
T
L
V
K
G
E
N
M
H
--
S
P
E
K
Y
A
K
L
I
L
K
A
R
-
P
M
F
V
E
A
K
A
-
Y
M
N
--
R
L
T
I
-----
N
------------
N
---
M
P
S
H
Q
D
I
R
E
F
A
E
A
L
V
K
H
L
P
G
Y
H
I
E
D
E
Y
--
E
P
S
R
V
V
L
I
M
R
D
D
V
D
P
Q
G
T
G
V
E
G
R
F
I
K
H
29
HHSearch
47.04
16%
-15
- C3 -
-
5VSL
2
?
A:
[30-215]
------------------------------------------------------------------------------------------------------
V
S
V
N
Y
H
F
T
R
-----
Q
C
N
Y
K
C
G
F
C
F
H
T
A
K
T
---------
S
-
F
V
-----
L
P
----
L
E
E
A
K
R
G
L
----
L
L
L
----------
K
Q
-------------
A
G
-
L
E
K
I
N
F
S
G
-
G
E
P
F
L
Q
----
D
----
R
G
E
Y
L
G
K
L
V
R
F
C
K
E
-
E
-
L
A
---
L
P
S
V
S
I
V
S
N
G
S
L
I
--------
R
E
R
W
-
F
-
K
D
Y
-
G
E
-
Y
L
D
-
I
L
A
I
S
C
D
S
F
D
E
Q
V
N
A
L
I
G
R
G
Q
G
K
K
N
H
V
E
N
L
Q
K
L
R
R
W
C
R
D
Y
----
K
---
V
---
A
F
K
I
N
S
V
I
N
R
F
-
N
V
D
-
E
D
M
N
E
H
I
K
A
L
S
----
P
V
R
W
K
V
F
Q
-
C
L
L
I
E
----------------------------------------------------------------------------------
21
HHSearch
46.57
12%
-33
- C3 -
-
4U0O
4
LIPA2_THEEB
B:
[53-273]
------------------------------------------------------------------------------------------------------
T
A
T
F
L
L
L
G
P
-----
T
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
--------
A
P
-
A
A
-----
V
D
----
P
E
E
P
T
K
I
A
A
----
A
V
----------
A
T
-------------
L
G
-
L
R
Y
V
V
L
T
S
-
V
A
R
D
D
L
----
P
DQGA
G
--
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
G
T
-----
E
I
E
V
L
S
P
D
F
R
M
DRGRLSQR
D
C---
I
-
A
Q
I
V
A
A
-
Q
P
A
-
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
G
----
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
N
P--
D
---
I
---
P
T
K
S
G
L
M
L
--
G
L
G
E
T
E
A
E
I
I
E
T
L
K
D
L
R
R
V
G
-
C
D
R
L
T
L
G
Q
-
Y
L
P
P
S
-
L
S
H
-----
L
------------
P
VVK
Y
W
T
P
E
E
F
N
T
L
G
N
I
A
R
E
L
G
F
S
H
-----------------------------------
30
HHSearch
45.84
16%
-18
- C3 -
-
5VSM
2
?
A:
[30-215]
------------------------------------------------------------------------------------------------------
V
S
V
N
Y
H
F
T
R
-----
Q
C
N
Y
K
C
G
F
C
F
H
T
A
K
T
---------
S
-
F
V
-----
L
P
----
L
E
E
A
K
R
G
L
----
L
L
L
----------
K
Q
-------------
A
G
-
L
E
K
I
N
F
S
G
-
G
E
P
F
L
Q
----
D
----
R
G
E
Y
L
G
K
L
V
R
F
C
K
E
-
E
-
L
A
---
L
P
S
V
S
I
V
S
N
G
S
L
I
--------
R
E
R
W
-
F
-
K
D
Y
-
G
E
-
Y
L
D
-
I
L
A
I
S
C
D
S
F
D
E
Q
V
N
A
L
I
G
R
G
Q
G
K
K
N
H
V
E
N
L
Q
K
L
R
R
W
C
R
D
Y
----
K
---
V
---
A
F
K
I
N
S
V
I
N
R
F
-
N
V
D
-
E
D
M
N
E
H
I
K
A
L
S
----
P
V
R
W
K
V
F
Q
-
C
L
L
I
E
----------------------------------------------------------------------------------
20
HHSearch
44.46
23%
10
- C3 -
-
2FB2
1
MOAA_STAA8
A:
[14-200]
------------------------------------------------------------------------------------------------------
R
D
L
A
L
S
V
T
D
-----
R
C
N
F
R
C
D
Y
C
M
P
K
E
V
F
GDDFVFLP
K
N
-
E
L
-----
L
T
----
F
D
E
M
A
R
I
A
K
----
V
Y
----------
A
E
-------------
L
G
-
V
K
K
I
R
I
T
G
-
G
E
P
L
M
R
---------
R
--
D
L
D
V
L
I
A
K
L
N
Q
I
D
-
G
I
----
E
D
I
G
L
T
T
N
G
L
L
L
--------
K
KH--
G
-
Q
K
L
Y
D
A
-
G
L
R
-
R
I
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
N
N
R
N
---
I
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
----
G
---
L
---
N
V
K
V
N
V
V
I
Q
K
G
I
N
D
--
D
Q
I
I
P
M
L
E
Y
F
K
D
K
--
H
I
E
I
R
F
I
E
-
F
M
D
V
G
----------------------------------------------------------------------------------
15
HHSearch
44.39
14%
-24
- C3 -
-
2YX0
-
TYW1_PYRHO
A:
[11-304]
--------------------------------------
K
I
T
V
Q
A
N
P
N
M
P
K
E
V
A
E
L
F
R
K
Q
H
Y
E
I
V
G
R
H
S
G
-
V
K
L
C
H
W
L
K
K
S
L
-
T
E
G
R
F
C
Y
K
Q
-
K
F
Y
G
I
H
S
H
R
C
L
Q
M
T
P
V
L
-
A
-----
W
C
T
H
N
C
I
F
C
W
R
P
M
E
N
--------
F
L
G
T
E
LPQPW
D
D
P
A
F
I
V
E
E
S
I
K
A
Q
R
K
L
L
I
G
Y
----------
K
-PKVDK
K
K
F
E
--
E
A
W
N
-
P
T
H
A
A
I
S
L
S
G
E
P
M
L
Y
---------
P
--
Y
M
G
D
L
V
E
E
F
H
K
-
R
-
G
F
-----
T
T
F
I
V
T
N
G
T
I
P
--------
E
R
---
L
E
E
M
I
K
E
D
K
L
P
T
-
Q
L
Y
V
S
I
T
A
P
D
I
E
T
Y
N
S
V
N
I
P
M
I
-
P
D
G
W
E
R
I
L
R
F
L
E
L
M
R
D
L
----
P
---
T
---
R
T
V
V
R
L
T
L
V
K
G
E
N
M
--
H
S
P
E
K
Y
A
K
L
I
L
K
A
R
-
P
M
F
V
E
A
K
A
-
Y
M
-------NRLTI
N
------------
N
---
M
P
S
H
Q
D
I
R
E
F
A
E
A
L
V
K
----------------------------------------
24
HHSearch
44.13
12%
-16
- C3 -
-
5EXJ
3
LIPA_MYCTU
A:
[91-318]
------------------------------------------------------------------------------------------------------
E
A
T
F
L
I
G
G
D
-----
Q
C
T
R
R
C
D
F
C
Q
I
D
T
G
K
---------
P
-
A
E
-----
L
D
----
R
D
E
P
R
R
V
A
D
----
S
V
----------
R
T
-------------
M
G
-
L
R
Y
A
T
V
T
G
-
V
A
R
D
D
L
PDGG
A
----
W
--
L
Y
A
A
T
V
R
A
I
K
E
-
L
-
N
P
S
---
T
G
V
E
L
L
I
P
D
F
N
G
--------
E
P
T
R
-
L
-
A
E
V
F
E
S
-
G
P
E
-
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
A
----
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
A
----
G
---
L
---
V
T
K
S
N
L
I
L
G
L
--
G
E
T
S
D
E
V
R
T
A
L
G
D
L
R
D
A
G
-
C
D
I
V
T
I
T
Q
Y
L
R
P
S
A
R
H
H
P
-----
V
------------
E
R
--
W
V
K
P
E
E
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
G
V
L
A
G
P
L
V
R
S
S
Y
R
A
G
R
L
-------------------