@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0692: (2017-12-27 )
MREYDIIAIGGGSGGIATMNRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVFAWEELPESVAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTSSEEFVTMR
Atome Classification :
(36 SA)
.........10.....-...20........30.....---------...40........50........60........70----...--.....80........90........100-..-.....110-......---.--120..--..---------...130.......140....---.---..150.......160.....---------..170.......180......---.190.......200.......210.......220.......230....-.-.-.-240.---.....------.-.---------250-.......260.......270.......280.......290.......300.-...----...310.......320.--......330.......340.......350.......360.......370.--.----.-....380.---.--.-....390.......400.......410.......420.......430......---.440......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
E
Y
D
I
I
A
I
GGGSG
G
I
-
A
T
MNRAGEHGA
Q
A
A
V
I
E
EKK---------LG
G
T
C
V
NVGCV
P
K
K
I
M
W
Y
G
A
Q
I
A
E
T
F
H
Q
F
G
E
DYGF----KTT--DLNF
D
F
A
T
L
R
R
N
R
E
S
Y
I
D
R
A
RSSYDGSF-KR-NG
V
D
L
I
E
G
-
H
A
E
F
V
D---S--
H
T
V
SV--N
G
---------
E
L
I
R
A
K
H
I
V
I
A
TGAHPSIPN---I---PGAELGGSSDDV
F
A
W
E
ELP
E
---------
S
V
A
I
LGA
G
Y
I
A
V
E
L
A
G
V
L
H
T
F---GVKT
D
L
F
V
RRDRPLR
G
F
D
S
Y
I
V
E
G
L
V
K
E
M
E
RTNLPLHTHKV
P
V
K
L
EKT-T-D-
G
-
I
T
-
I
---
H
FEDG------T-S---------HTA-
S
Q
V
I
W
ATGRRPNVK
G
L
Q
L
EKAG
V
T
LNERG
F
I
Q
V
D
E
Y
Q
N
T
V
V
E
G
I
Y
A
LGDVT-GEK----EL
T
P
V
A
I
KAG
R
T
L
S
E
R
L--FNGK
T
T
A
K
M
DYSTI
P
T
V
V
FSHPAIGTVGL
T
E
E
Q
A
I
K
E
Y
G
Q
D
Q
I
K
V
Y
K
S
S
F
--
A
----
S
-
M
Y
S
A
C
TRN---R--Q-E
S
R
F
K
L
I
TAGSE
E
K
V
V
G
LHGIGY
G
V
D
E
M
I
Q
G
F
A
V
A
I
KMGATKADF
D
A
T
V
A
IHP---TSSE
E
F
V
TMR
128
HHSearch
97.07
59%
-58
- C1 -
-
5VDN
4
?
B:
[15-462]
T
K
H
Y
D
Y
L
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
K
K
C
A
L
I
E
A
K
Q
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
A
E
A
I
H
L
Y
G
P
D
Y
G
F
----
D
T
T
--
V
N
H
F
D
W
K
K
L
I
A
N
R
T
A
Y
I
D
R
I
H
Q
S
Y
E
R
G
L
-
G
N
-
N
K
V
D
V
I
Q
G
-
F
A
R
F
V
D
---
A
--
H
T
V
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
A
E
Y
G
I
D
S
D
G
F
F
E
L
D
E
M
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
N
G
L
---
G
T
E
T
H
L
F
V
R
K
H
A
P
L
R
T
F
D
P
L
I
V
E
T
L
L
E
V
M
N
T
E
G
P
K
L
H
T
E
S
V
P
K
A
V
I
K
N
A
D
-
G
-
S
-
L
T
-
L
---
Q
L
E
N
G
------
T
-
E
---------
V
T
V
-
D
H
L
I
W
A
I
G
R
E
P
A
T
D
N
L
N
L
S
V
T
G
V
K
T
N
D
K
G
Y
I
E
V
D
K
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
N
T
-
G
V
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
E
P
Q
A
R
E
K
F
G
D
D
Q
V
K
V
Y
T
S
S
F
--
T
----
A
-
M
Y
S
A
---
V
T--
Q
H-
R
Q
P
C
R
M
K
L
V
C
V
G
A
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
I
L
Q
G
F
A
V
A
M
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
-
111
HHSearch
94.73
59%
-56
- C1 -
-
1GES
2
GSHR_ECOLI
B:
[2-449]
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
-
G
-
S
-
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
---
V
T--
T
H-
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
-
24
PsiBlast_CBE
94.24
59%
-51
- C1 -
-
5VDN
4
?
B:
[16-463]
-
K
H
Y
D
Y
L
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
K
K
C
A
L
I
E
A
K
Q
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
A
E
A
I
H
L
Y
G
P
D
Y
G
F
----
D
T
T
--
V
N
H
F
D
W
K
K
L
I
A
N
R
T
A
Y
I
D
R
I
H
Q
S
Y
E
R
G
L
-
G
N
-
N
K
V
D
V
I
Q
G
-
F
A
R
F
V
D
---
A
--
H
T
V
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
A
E
Y
G
I
D
S
D
G
F
F
E
L
D
E
M
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
N
G
L
---
G
T
E
T
H
L
F
V
R
K
H
A
P
L
R
T
F
D
P
L
I
V
E
T
L
L
E
V
M
N
T
E
G
P
K
L
H
T
E
S
V
P
K
A
V
I
K
N
-
A
-
D
-
G
S
L
T
-
L
---
Q
L
E
N
G
------
T
-
E
---------
V
T
V
-
D
H
L
I
W
A
I
G
R
E
P
A
T
D
N
L
N
L
S
V
T
G
V
K
T
N
D
K
G
Y
I
E
V
D
K
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
N
T
-
G
V
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
E
P
Q
A
R
E
K
F
G
D
D
Q
V
K
V
Y
T
S
S
F
--
T
----
A
-
M
Y
S
A
V
T
Q
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
A
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
I
L
Q
G
F
A
V
A
M
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
23
PsiBlast_CBE
93.75
61%
-51
- C1 -
-
1GER
2
GSHR_ECOLI
B:
[3-450]
-
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
S
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
V
T
T
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
2
PsiBlast_PDB
93.38
61%
-50
- C1 -
-
1GER
2
GSHR_ECOLI
A:
[3-450]
-
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
S
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
V
T
T
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
4
PsiBlast_PDB
92.97
59%
-50
- C1 -
-
5VDN
4
?
A:
[16-463]
-
K
H
Y
D
Y
L
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
K
K
C
A
L
I
E
A
K
Q
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
A
E
A
I
H
L
Y
G
P
D
Y
G
F
----
D
T
T
--
V
N
H
F
D
W
K
K
L
I
A
N
R
T
A
Y
I
D
R
I
H
Q
S
Y
E
R
G
L
-
G
N
-
N
K
V
D
V
I
Q
G
-
F
A
R
F
V
D
---
A
--
H
T
V
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
A
E
Y
G
I
D
S
D
G
F
F
E
L
D
E
M
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
N
G
L
---
G
T
E
T
H
L
F
V
R
K
H
A
P
L
R
T
F
D
P
L
I
V
E
T
L
L
E
V
M
N
T
E
G
P
K
L
H
T
E
S
V
P
K
A
V
I
K
N
-
A
-
D
-
G
S
L
T
-
L
---
Q
L
E
N
G
------
T
-
E
---------
V
T
V
-
D
H
L
I
W
A
I
G
R
E
P
A
T
D
N
L
N
L
S
V
T
G
V
K
T
N
D
K
G
Y
I
E
V
D
K
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
N
T
-
G
V
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
E
P
Q
A
R
E
K
F
G
D
D
Q
V
K
V
Y
T
S
S
F
--
T
----
A
-
M
Y
S
A
V
T
Q
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
A
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
I
L
Q
G
F
A
V
A
M
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
22
PsiBlast_CBE
92.68
61%
-51
- C1 -
-
1GET
3
GSHR_ECOLI
B:
[3-450]
-
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
S
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
V
T
T
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
3
PsiBlast_PDB
91.94
61%
-53
- C1 -
-
1GET
3
GSHR_ECOLI
A:
[3-450]
-
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
S
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
V
T
T
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
117
HHSearch
91.92
59%
-57
- C1 -
-
5V36
1
?
B:
[5-452]
T
K
Q
Y
D
Y
I
V
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
H
G
A
K
V
I
L
F
E
G
K
Q
---------
V
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
G
A
Q
V
A
E
T
I
N
N
Y
A
A
D
Y
G
F
----
D
V
T
--
T
Q
A
F
H
F
D
V
L
K
Q
N
R
Q
A
Y
I
D
R
I
H
D
S
Y
E
R
G
F
-
D
S
-
N
G
V
E
R
V
Y
G
-
Y
A
T
F
V
D
---
A
--
H
T
V
E
V
--
A
G
---------
E
H
Y
T
A
P
H
I
L
I
A
T
G
G
H
A
L
L
P
D
---
I
---
P
G
S
E
Y
G
I
T
S
D
G
F
F
E
L
D
A
I
P
K
---------
R
T
A
V
V
G
A
G
Y
I
A
V
E
I
S
G
I
L
H
A
L
---
G
S
E
T
H
L
F
V
R
R
D
R
P
L
R
K
F
D
K
E
I
V
G
T
L
V
D
E
M
K
K
D
G
P
H
L
H
T
F
S
V
P
K
E
V
I
K
N
T
D
-
N
-
S
-
L
T
-
L
---
I
L
E
N
G
------
E
-
E
---------
Y
T
V
-
D
T
L
I
W
A
I
G
R
A
A
N
T
K
G
F
N
L
E
V
T
G
V
T
L
D
S
R
G
F
I
A
T
D
A
F
E
N
T
N
V
E
G
L
Y
A
L
G
D
V
N
-
G
K
L
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
H
K
P
Q
A
K
M
D
Y
K
D
V
A
T
V
I
F
S
H
P
V
I
G
S
I
G
L
S
E
E
A
A
L
D
Q
Y
G
E
E
N
V
T
V
Y
R
S
T
F
--
T
----
S
-
M
Y
T
A
---
V
T--
S
H-
R
Q
A
C
K
M
K
L
V
T
V
G
E
D
E
K
I
V
G
L
H
G
I
G
Y
G
V
D
E
M
I
Q
G
F
A
V
A
I
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
-
1
PsiBlast_PDB
90.99
59%
-51
- C1 -
-
5V36
3
?
A:
[6-453]
-
K
Q
Y
D
Y
I
V
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
H
G
A
K
V
I
L
F
E
G
K
Q
---------
V
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
G
A
Q
V
A
E
T
I
N
N
Y
A
A
D
Y
G
F
----
D
V
T
--
T
Q
A
F
H
F
D
V
L
K
Q
N
R
Q
A
Y
I
D
R
I
H
D
S
Y
E
R
G
F
-
D
S
-
N
G
V
E
R
V
Y
G
-
Y
A
T
F
V
D
---
A
--
H
T
V
E
V
--
A
G
---------
E
H
Y
T
A
P
H
I
L
I
A
T
G
G
H
A
L
L
P
D
---
I
---
P
G
S
E
Y
G
I
T
S
D
G
F
F
E
L
D
A
I
P
K
---------
R
T
A
V
V
G
A
G
Y
I
A
V
E
I
S
G
I
L
H
A
L
---
G
S
E
T
H
L
F
V
R
R
D
R
P
L
R
K
F
D
K
E
I
V
G
T
L
V
D
E
M
K
K
D
G
P
H
L
H
T
F
S
V
P
K
E
V
I
K
N
-
T
-
D
-
N
S
L
T
-
L
---
I
L
E
N
G
------
E
-
E
---------
Y
T
V
-
D
T
L
I
W
A
I
G
R
A
A
N
T
K
G
F
N
L
E
V
T
G
V
T
L
D
S
R
G
F
I
A
T
D
A
F
E
N
T
N
V
E
G
L
Y
A
L
G
D
V
N
-
G
K
L
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
H
K
P
Q
A
K
M
D
Y
K
D
V
A
T
V
I
F
S
H
P
V
I
G
S
I
G
L
S
E
E
A
A
L
D
Q
Y
G
E
E
N
V
T
V
Y
R
S
T
F
--
T
----
S
-
M
Y
T
A
V
T
S
H
---
R
--
Q
-
A
C
K
M
K
L
V
T
V
G
E
D
E
K
I
V
G
L
H
G
I
G
Y
G
V
D
E
M
I
Q
G
F
A
V
A
I
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
27
PsiBlast_CBE
90.91
58%
-51
- C1 -
-
5U1O
2
?
D:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
E
D
Y
G
F
----
D
V
D
--
V
K
G
F
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
-
N
K
V
N
V
I
K
G
-
F
A
K
F
V
D
---
E
--
K
T
V
E
V
--
N
G
---------
E
H
Y
T
A
D
H
I
L
I
A
V
G
G
R
P
T
I
P
N
---
I
---
P
G
A
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
L
---
G
T
E
T
H
L
F
V
R
K
E
S
P
L
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
E
-
A
-
D
-
G
S
L
T
-
L
---
H
L
E
N
G
------
E
-
S
---------
Q
N
V
-
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
D
I
M
E
G
G
I
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
--
T
----
A
-
M
Y
T
A
V
T
K
H
---
R
--
Q
-
P
C
K
M
K
L
V
C
A
G
E
E
E
T
V
V
G
L
H
G
I
G
F
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
29
PsiBlast_CBE
90.41
58%
-48
- C1 -
-
5U1O
2
?
B:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
E
D
Y
G
F
----
D
V
D
--
V
K
G
F
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
-
N
K
V
N
V
I
K
G
-
F
A
K
F
V
D
---
E
--
K
T
V
E
V
--
N
G
---------
E
H
Y
T
A
D
H
I
L
I
A
V
G
G
R
P
T
I
P
N
---
I
---
P
G
A
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
L
---
G
T
E
T
H
L
F
V
R
K
E
S
P
L
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
E
-
A
-
D
-
G
S
L
T
-
L
---
H
L
E
N
G
------
E
-
S
---------
Q
N
V
-
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
D
I
M
E
G
G
I
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
--
T
----
A
-
M
Y
T
A
V
T
K
H
---
R
--
Q
-
P
C
K
M
K
L
V
C
A
G
E
E
E
T
V
V
G
L
H
G
I
G
F
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
21
PsiBlast_CBE
89.65
59%
-52
- C1 -
-
5V36
1
?
B:
[6-453]
-
K
Q
Y
D
Y
I
V
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
H
G
A
K
V
I
L
F
E
G
K
Q
---------
V
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
G
A
Q
V
A
E
T
I
N
N
Y
A
A
D
Y
G
F
----
D
V
T
--
T
Q
A
F
H
F
D
V
L
K
Q
N
R
Q
A
Y
I
D
R
I
H
D
S
Y
E
R
G
F
-
D
S
-
N
G
V
E
R
V
Y
G
-
Y
A
T
F
V
D
---
A
--
H
T
V
E
V
--
A
G
---------
E
H
Y
T
A
P
H
I
L
I
A
T
G
G
H
A
L
L
P
D
---
I
---
P
G
S
E
Y
G
I
T
S
D
G
F
F
E
L
D
A
I
P
K
---------
R
T
A
V
V
G
A
G
Y
I
A
V
E
I
S
G
I
L
H
A
L
---
G
S
E
T
H
L
F
V
R
R
D
R
P
L
R
K
F
D
K
E
I
V
G
T
L
V
D
E
M
K
K
D
G
P
H
L
H
T
F
S
V
P
K
E
V
I
K
N
-
T
-
D
-
N
S
L
T
-
L
---
I
L
E
N
G
------
E
-
E
---------
Y
T
V
-
D
T
L
I
W
A
I
G
R
A
A
N
T
K
G
F
N
L
E
V
T
G
V
T
L
D
S
R
G
F
I
A
T
D
A
F
E
N
T
N
V
E
G
L
Y
A
L
G
D
V
N
-
G
K
L
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
H
K
P
Q
A
K
M
D
Y
K
D
V
A
T
V
I
F
S
H
P
V
I
G
S
I
G
L
S
E
E
A
A
L
D
Q
Y
G
E
E
N
V
T
V
Y
R
S
T
F
--
T
----
S
-
M
Y
T
A
V
T
S
H
---
R
--
Q
-
A
C
K
M
K
L
V
T
V
G
E
D
E
K
I
V
G
L
H
G
I
G
Y
G
V
D
E
M
I
Q
G
F
A
V
A
I
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
7
PsiBlast_PDB
89.64
58%
-47
- C1 -
-
5U1O
2
?
A:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
E
D
Y
G
F
----
D
V
D
--
V
K
G
F
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
-
N
K
V
N
V
I
K
G
-
F
A
K
F
V
D
---
E
--
K
T
V
E
V
--
N
G
---------
E
H
Y
T
A
D
H
I
L
I
A
V
G
G
R
P
T
I
P
N
---
I
---
P
G
A
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
L
---
G
T
E
T
H
L
F
V
R
K
E
S
P
L
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
E
-
A
-
D
-
G
S
L
T
-
L
---
H
L
E
N
G
------
E
-
S
---------
Q
N
V
-
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
D
I
M
E
G
G
I
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
--
T
----
A
-
M
Y
T
A
V
T
K
H
---
R
--
Q
-
P
C
K
M
K
L
V
C
A
G
E
E
E
T
V
V
G
L
H
G
I
G
F
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
28
PsiBlast_CBE
89.16
58%
-49
- C1 -
-
5U1O
2
?
C:
[12-458]
---
F
D
Y
I
C
I
G
G
G
S
G
G
I
-
A
S
A
N
R
A
A
M
Y
G
A
K
V
A
L
I
E
A
Q
D
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
G
A
Q
I
A
E
A
M
N
L
Y
A
E
D
Y
G
F
----
D
V
D
--
V
K
G
F
D
W
S
K
L
V
E
S
R
Q
A
Y
I
G
R
I
H
Q
S
Y
D
R
V
L
-
G
N
-
N
K
V
N
V
I
K
G
-
F
A
K
F
V
D
---
E
--
K
T
V
E
V
--
N
G
---------
E
H
Y
T
A
D
H
I
L
I
A
V
G
G
R
P
T
I
P
N
---
I
---
P
G
A
E
Y
G
I
D
S
N
G
F
F
D
L
A
E
Q
P
K
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
I
A
G
V
L
H
A
L
---
G
T
E
T
H
L
F
V
R
K
E
S
P
L
R
S
F
D
P
M
I
I
D
T
L
V
E
V
M
E
A
E
G
P
T
L
H
T
H
S
V
P
K
E
V
V
K
E
-
A
-
D
-
G
S
L
T
-
L
---
H
L
E
N
G
------
E
-
S
---------
Q
N
V
-
D
Q
L
I
W
A
I
G
R
H
P
A
T
D
A
I
N
L
A
S
T
G
V
A
T
N
E
K
G
Y
I
K
V
D
E
Y
Q
E
T
N
V
K
G
I
Y
C
V
G
D
I
M
E
G
G
I
----
E
L
T
P
V
A
V
K
A
G
R
Q
L
S
E
R
L
--
F
N
N
K
P
N
A
K
M
D
Y
D
L
V
P
T
V
V
F
S
H
P
P
I
G
T
I
G
L
T
T
Q
E
A
E
E
K
Y
G
K
D
N
I
K
V
Y
T
S
G
F
--
T
----
A
-
M
Y
T
A
V
T
K
H
---
R
--
Q
-
P
C
K
M
K
L
V
C
A
G
E
E
E
T
V
V
G
L
H
G
I
G
F
T
V
D
E
M
I
Q
G
F
G
V
A
M
K
M
G
A
T
K
A
D
F
D
S
V
V
A
I
H
P
---
T
G
S
E
E
F
V
T
M
R
113
HHSearch
86.49
49%
-61
- C1 -
-
2R9Z
2
GASHR_MARGR
B:
[2-447]
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
R
D
-
A
P
G
F
G
V
----
Q
A
S
--
G
-
T
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
-
L
G
I
T
R
V
D
G
-
H
A
R
F
V
D
---
A
--
H
T
I
E
V
--
E
G
---------
Q
R
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
R
---
L
---
P
G
A
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
F
---
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
-
A
-
Q
-
G
-
T
T
-
L
---
V
A
Q
D
G
T-----
R
-
L
---------
E
G
F
-
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
-
G
R
D
----
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
--
T
----
P
-
M
R
Y
A
---
L
N--
E
H-
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
-
112
HHSearch
85.73
49%
-61
- C1 -
-
2R9Z
2
GASHR_MARGR
A:
[2-447]
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
R
D
-
A
P
G
F
G
V
----
Q
A
S
-----
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
-
L
G
I
T
R
V
D
G
-
H
A
R
F
V
D
---
A
--
H
T
I
E
V
--
E
G
---------
Q
R
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
R
---
L
---
P
G
A
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
F
---
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
-
A
-
Q
-
G
-
T
T
-
L
---
V
A
Q
D
G
T
-----
R
-
L
---------
E
G
F
-
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
-
G
R
D
----
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
--
T
----
P
-
M
R
Y
A
---
L
N--
E
H-
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
-
30
PsiBlast_CBE
84.61
48%
-55
- C1 -
-
2R9Z
2
GASHR_MARGR
B:
[3-448]
-
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
K
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
R
D
-
A
P
G
F
G
V
----
Q
A
S
--
G
-
T
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
-
E
R
-
L
G
I
T
R
V
D
G
-
H
A
R
F
V
D
---
A
--
H
T
I
E
V
--
E
G
---------
Q
R
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
R
---
L
---
P
G
A
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
F
---
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
-
A
-
Q
-
G
-
T
T
-
L
---
V
A
Q
D
G
------
T
-
R
---------
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
-
G
R
D
----
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
V
L
T
V
Y
E
T
S
F
--
T
----
P
-
M
R
Y
A
L
N
E
H
---
G
--
P
-
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
5
PsiBlast_PDB
83.40
59%
-45
- C1 -
-
1GES
2
GSHR_ECOLI
A:
[21-450]
--------------------
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
S
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
V
T
T
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
6
PsiBlast_PDB
83.00
59%
-41
- C1 -
-
1GEU
3
GSHR_ECOLI
A:
[21-450]
--------------------
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
Y
G
F
----
D
T
T
--
I
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
-
N
N
V
D
V
I
K
G
-
F
A
R
F
V
D
---
A
--
K
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---
I
---
P
G
V
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
S
L
T
-
L
---
E
L
E
D
G
------
R
-
S
---------
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
V
----
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
--
T
----
A
-
M
Y
T
A
V
T
T
H
---
R
--
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
39
PsiBlast_CBE
80.04
49%
-11
- C1 -
-
3DJG
2
GSHR_HUMAN
X:
[20-477]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
-
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
DP-
K
--
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ESQ
I
---
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
---
S
M
V
T
A
------
V
-
P
GRLPVMTMI
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
V
T
K
R
---
K
--
T
-
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
38
PsiBlast_CBE
79.88
49%
-14
- C1 -
-
3DJJ
10
GSHR_HUMAN
A:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
-
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
DP-
K
--
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ESQ
I
---
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
---
S
M
V
T
A
------
V
-
P
GR
L
P
V
M
T
M
I
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
V
T
K
R
---
K
--
T
-
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
36
PsiBlast_CBE
79.59
49%
-14
- C1 -
-
3DK8
5
GSHR_HUMAN
A:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
-
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
DP-
K
--
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ESQ
I
---
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
---
S
M
V
T
A
------
V
-
P
GR
L
P
V
M
T
M
I
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
V
T
K
R
---
K
--
T
-
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
37
PsiBlast_CBE
79.28
49%
-12
- C1 -
-
3DK4
2
GSHR_HUMAN
A:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
-
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
DP-
K
--
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ESQ
I
---
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
---
S
M
V
T
A
------
V
-
P
GR
L
P
V
M
T
M
I
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
V
T
K
R
---
K
--
T
-
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
114
HHSearch
78.04
51%
-7
- C1 -
-
3DK9
1
GSHR_HUMAN
A:
[19-478]
-
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
-
H
A
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
---
D
PK
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
---
E
SQI
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
S
M
V
T
A
V
P
G
R
L
P
V
M
T
M
-
I
---------
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
---
V
T--
K
R
-
K
T
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
41
PsiBlast_CBE
75.88
49%
-8
- C1 -
-
1GRF
2
GSHR_HUMAN
A:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
-
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
DP-
K
--
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ESQ
I
---
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
---
S
M
V
T
A
------
V
-
P
GR
L
P
V
M
T
M
I
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
V
T
K
R
---
K
--
T
-
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
40
PsiBlast_CBE
75.47
49%
-9
- C1 -
-
2GH5
12
GSHR_HUMAN
B:
[21-478]
---
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
-
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
DP-
K
--
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ESQ
I
---
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
---
S
M
V
T
A
------
V
-
P
GRLPVMTMI
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
V
T
K
R
---
K
--
T
-
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
115
HHSearch
75.13
50%
-4
- C1 -
-
2GRT
1
GSHR_HUMAN
A:
[1-461]
V
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
G
A
R
A
A
V
V
E
S
H
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
-
H
A
D
Y
G
F
----
P
S
C
--
E
G
K
F
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
-
T
K
-
S
H
I
E
I
I
R
G
-
H
A
A
F
T
S
---
D
P
K
P
T
I
E
V
--
S
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
---
E
SQI
P
G
A
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
A
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
-
L
-
S
-
G
-
L
E
-
V
S
M
V
T
A
V
P
G
R
L
P
V
M
T
M
-
I
---------
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
-
G
K
A
----
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
----
P
-
M
Y
H
A
---
V
T--
K
R
-
K
T
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
126
HHSearch
73.22
44%
-40
- C1 -
-
1ONF
1
GSHR_PLAFK
A:
[2-495]
--
V
Y
D
L
I
V
I
G
G
G
S
G
G
M
-
A
A
A
R
R
A
A
R
H
N
A
K
V
A
L
V
E
K
S
R
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
E
N
-
S
R
H
Y
G
F
----
D
T
---
K
F
S
F
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
L
-
S
K
-
D
K
V
D
L
Y
E
G
-
T
A
S
F
L
----------------------------
E
G
R
N
I
L
I
A
V
G
N
K
P
V
F
P
P
---
V
---
K
G
I
E
N
T
I
S
S
D
E
F
F
N
I
K
-
E
S
K
---------
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
R
L
---
G
I
D
S
Y
I
F
A
R
G
N
R
I
L
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
V
S
D
-
K
-
N
-
L
S
-
I
---
H
L
S
D
G
------
R
I
Y
---------
E
H
F
-
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
N
-
N
N
Y
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
C
C
-
M
V
K
F
Y
N
V
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
--
F
L
K
K
-
T
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
N
V
K
I
Y
E
S
K
F
--
T
----
N
-
L
F
F
S
V
Y
D
I
EPE
L
K
-
E
-
K
T
Y
L
K
L
V
C
V
G
K
D
E
L
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
---
T
A
A
E
E
F
L
T
L
-
102
Fugue
71.24
56%
29
- C1 -
-
1GER
2
GSHR_ECOLI
A:
[3-450]
-
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
G
Q
K
C
A
L
I
E
A
K
-E--------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
GFDT
T
I
----
N
K
F
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
-
G
K
N
N
-
V
D
V
I
K
-
G
F
A
R
F
V
-DAK----
T
L
E
V
--
N
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
D
---------
I
P
-
G
V
--
E
Y
G
I
D
---
S
D
G
F
F
A
LPALPE
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
G
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
-
T
-
D
-
G
-
S
L
-
T
---
L
E
L
E
D
G
R
----
S
-
E
---------
T
-
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
-
G
A
-V---
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
FN--
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A-----
M
-
Y
T
A
V
T
T
H
R
------
Q
-
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
--
V
A
I
H
PT-
A
A
E
E
F
V
T
M
R
42
PsiBlast_CBE
70.38
39%
-35
- C1 -
-
1ONF
1
GSHR_PLAFK
A:
[3-496]
---
Y
D
L
I
V
I
G
G
G
S
G
G
M
-
A
A
A
R
R
A
A
R
H
N
A
K
V
A
L
V
E
K
S
R
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
E
N
-
S
R
H
Y
G
F
----
D
T
K
---
F
S
F
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
L
-
S
K
-
D
K
V
D
L
Y
E
G
-
T
A
S
F
L
----------------------------
E
G
R
N
I
L
I
A
V
G
N
K
P
V
F
P
P
---
V
---
K
G
I
E
N
T
I
S
S
D
E
F
F
N
I
K
E
-
S
K
---------
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
R
L
---
G
I
D
S
Y
I
F
A
R
G
N
R
I
L
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
V
-
S
-
D
K
N
-
L
S
-
I
---
H
L
S
D
G
------
R
-
I
---------
Y
E
H
F
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
N
-
N
N
Y
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
C
C
-
M
V
K
F
Y
N
V
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
--
F
-
L
K
K
T
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
N
V
K
I
Y
E
S
K
F
--
T
N
LFF
S
-
V
Y
D
I
E
P
E
L
---
K
--
E
-
K
T
Y
L
K
L
V
C
V
G
K
D
E
L
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
---
T
A
A
E
E
F
L
T
L
Q
116
HHSearch
67.90
39%
-14
- C1 -
-
4DNA
2
?
A:
[3-449]
A
F
D
Y
D
L
F
V
I
G
G
G
S
G
G
V
-
R
S
G
R
L
A
A
A
L
G
K
K
V
A
I
A
E
E
F
R
---------
Y
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
V
Y
A
S
Q
F
A
E
H
F
E
D
-
A
A
G
F
G
W
----
T
V
G
--
E
S
R
F
D
W
A
K
L
V
A
A
K
E
Q
E
I
A
R
L
E
G
L
Y
R
K
G
L
-
A
N
-
A
G
A
E
I
L
D
T
-
R
A
E
L
A
G
---
P
--
N
T
V
K
L
LA
S
G
---------
K
T
V
T
A
E
R
I
V
I
A
V
G
G
H
P
S
P
H
D
A--
L
---
P
G
H
E
L
C
I
T
S
N
E
A
F
D
L
P
A
L
P
E
---------
S
I
L
I
A
G
G
G
Y
I
A
V
E
F
A
N
I
F
H
G
L
---
G
V
K
T
T
L
I
Y
R
G
K
E
I
L
S
R
F
D
Q
D
M
R
R
G
L
H
A
A
M
E
E
K
G
I
R
I
L
C
E
D
I
I
Q
S
V
S
A
D
-
A
D
G
-
R
R
V
A
-
T
---
T
M
-
K
H
------
G
-
E
---------
I
V
A
-
D
Q
V
M
L
A
L
G
R
M
P
N
T
N
G
L
G
L
E
A
A
G
V
R
T
N
E
L
G
A
I
I
V
D
A
F
S
R
T
S
T
P
G
I
Y
A
L
G
D
V
T
-
D
R
V
----
Q
L
T
P
V
A
I
H
E
A
M
C
F
I
E
T
E
--
Y
K
N
N
-
P
T
S
P
D
H
D
L
I
A
T
A
V
F
S
Q
P
E
I
G
T
V
G
I
T
E
E
E
A
A
R
K
F
--
Q
E
I
E
V
Y
R
A
E
F
--
R
----
P
-
M
K
A
T
---
L
---
S
GR
K
E
K
T
I
M
K
L
V
V
N
A
A
D
R
K
V
V
G
A
H
I
L
G
H
D
A
G
E
M
A
Q
L
L
G
I
S
L
R
A
G
C
T
K
D
D
F
D
R
T
M
A
V
H
P
---
T
A
A
E
E
L
V
T
M
-
48
PsiBlast_CBE
64.78
37%
1
- C1 -
-
4ADW
5
?
B:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
THGPPLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
R
E
S
G
-
G
F
G
W
----
E
M
D
RE
S
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
-
E
G
L
S
F
H
M
G
-
F
G
A
L
Q
D
---
A
--
H
T
V
V
V
--
R
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
G
---
V
---
P
G
D
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KPC
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
N
-
E
-
D
-
G
-
S
N
H
V
---
H
F
N
D
G
------
T
-
E
---------
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
T
-
N
R
V
----
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
T
-
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
--
T
----
P
L
M
H
N
I
S
G
S
K
---
H
--
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
49
PsiBlast_CBE
63.56
37%
2
- C1 -
-
4ADW
5
?
A:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
THGPPLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
R
E
S
G
-
G
F
G
W
----
E
M
D
RE
S
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
-
E
G
L
S
F
H
M
G
-
F
G
A
L
Q
D
---
A
--
H
T
V
V
V
--
R
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
G
---
V
---
P
G
D
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KPC
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
N
-
E
-
D
-
G
-
S
N
H
V
---
H
F
N
D
G
------
T
-
E
---------
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
T
-
N
R
V
----
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
T
-
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
--
T
----
P
L
M
H
N
I
S
G
S
K
---
H
--
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
45
PsiBlast_CBE
62.38
37%
1
- C1 -
-
5EBK
6
?
A:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
T
H
G
P
PLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
R
E
S
G
-
G
F
G
W
----
E
M
D
RE
S
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
-
E
G
L
S
F
H
M
G
-
F
G
A
L
Q
D
---
A
--
H
T
V
V
V
--
R
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
G
---
V
---
P
G
D
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KPC
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
N
-
E
-
D
-
G
-
S
N
H
V
---
H
F
N
D
G
------
T
-
E
---------
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
T
-
N
R
V
----
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
T
-
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
--
T
----
P
L
M
H
N
I
S
G
S
K
---
H
--
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
44
PsiBlast_CBE
62.10
37%
-1
- C1 -
-
5EBK
7
?
B:
[23-492]
-
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
A
T
H
G
P
PLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
L
I
R
E
S
G
-
G
F
G
W
----
E
M
D
RE
S
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
-
E
G
L
S
F
H
M
G
-
F
G
A
L
Q
D
---
A
--
H
T
V
V
V
--
R
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
G
---
V
---
P
G
D
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
KPC
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
N
-
E
-
D
-
G
-
S
N
H
V
---
H
F
N
D
G
------
T
-
E
---------
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
T
-
N
R
V
----
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
T
-
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
T
V
A
V
Y
A
S
S
F
--
T
----
P
L
M
H
N
I
S
G
S
K
---
H
--
K
-
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R