@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0731: (2017-12-28 )
MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEEGLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALLMEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREKDGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGVQISTSKKGK
Atome Classification :
(45 SA)
.........10....----...----.20........30........---40..-.-...-..-50........60........70........80......-..-90........100.......110.......120......-.-130.......140.......----150------......---.-160....--.....170.......180.......190.......200.-.-.-.-...-210....-...220.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
N
L
K
K
M
AG
I
K
A
A
E
F
----VSD----
G
M
V
V
G
LGTG
S
T
A
Y
Y
F
V
E
E
I
G
R
---
R
I
K
E-E-G
L
Q
-
I
T
-
A
V
TTSSVTTKQAEGLNIPLKSIDQ
V
D
F
V
D
V
T
VD
G
A
D
E
V
-
D
S
-
Q
FNGIKGG
G
G
A
L
L
M
E
K
V
VATPSK
E
Y
I
W
V
V
D
E
S
K
L
V
E
K
LG-A-FKL
P
V
E
V
V
Q
Y
G
A
E
Q
V
F
R
H
F
E
----RAG------YKPSFR---E-K--D
G
Q
R
--
F
V
T
D
M
Q
N
F
I
I
D
L
A
L
D
V
IEN
P
I
A
F
G
Q
E
L
D
H
V
V
G
V
V
E
H
G
L
F
-
N
-
Q
-
M
-
V
D
K
-
V
I
VAGRD-
G
V
Q
I
STSKKGK
73
HHSearch
88.20
54%
-67
- C9 -
-
4GMK
-
?
B:
[5-227]
-
D
E
L
K
Q
L
V
G
T
K
A
V
E
W
----
I
K
D
----
G
M
I
V
G
L
G
T
G
S
T
V
K
Y
M
V
D
A
L
G
K
---
R
V
N
E
-
E
-
G
L
D
-
I
V
-
G
V
T
T
S
I
R
T
A
E
Q
A
K
S
L
G
I
V
I
K
D
I
D
E
V
D
H
I
D
L
T
I
D
G
A
D
E
I
-
S
S
-
D
F
Q
G
I
K
G
G
G
A
A
L
L
Y
E
K
I
V
A
T
K
S
N
K
N
M
W
I
V
D
E
S
K
M
V
D
D
L
G
-
Q
-
F
P
L
P
V
E
V
I
P
Y
G
S
G
T
V
F
K
R
F
E
----
E
K
G
------
L
N
P
E
F
R
---
K
-
N
E-
D
G
S
L
--
L
H
T
D
S
D
N
Y
I
I
D
L
H
L
G
K
I
E
N
P
K
E
L
G
D
Y
L
I
N
Q
V
G
V
V
E
H
G
L
F
-
L
-
D
-
I
-
V
N
T
-
V
I
V
G
R
Q
D
-
G
P
E
V
L
E
A
----
69
HHSearch
87.56
75%
-
- C9 -
-
3L7O
-
RPIA_STRMU
B:
[2-224]
-
E
E
L
K
K
I
A
G
V
R
A
A
Q
Y
----
V
E
D
----
G
M
I
V
G
L
G
T
G
S
T
A
Y
Y
F
V
E
E
V
G
R
---
R
V
Q
E
-
E
-
G
L
Q
-
V
I
-
G
V
T
T
S
S
R
T
T
A
Q
A
Q
A
L
G
I
P
L
K
S
I
D
E
V
D
S
V
D
V
T
V
D
G
A
D
E
V
-
D
P
-
N
F
N
G
I
K
G
G
G
G
A
L
L
M
E
K
I
V
G
T
L
T
K
D
Y
I
W
V
V
D
E
S
K
M
V
D
T
L
G
-
A
-
F
R
L
P
V
E
V
V
Q
Y
G
A
E
R
L
F
R
E
F
E
----
K
K
G
------
Y
K
P
S
F
R
---
E
-
Y
--
D
G
V
R
--
F
V
T
D
M
K
N
F
I
I
D
L
D
L
G
S
I
P
D
P
I
A
F
G
N
M
L
D
H
Q
V
G
V
V
E
H
G
L
F
-
N
-
G
-
M
-
V
N
R
-
V
I
V
A
G
K
D
-
G
V
R
I
L
E
A
N
---
1
PsiBlast_PDB
86.05
74%
-
- C9 -
-
3L7O
-
RPIA_STRMU
A:
[2-225]
-
E
E
L
K
K
I
A
G
V
R
A
A
Q
Y
----
V
E
D
----
G
M
I
V
G
L
G
T
G
S
T
A
Y
Y
F
V
E
E
V
G
R
---
R
V
Q
E
-
E
-
G
L
Q
-
V
I
-
G
V
T
T
S
S
R
T
T
A
Q
A
Q
A
L
G
I
P
L
K
S
I
D
E
V
D
S
V
D
V
T
V
D
G
A
D
E
V
-
D
P
-
N
F
N
G
I
K
G
G
G
G
A
L
L
M
E
K
I
V
G
T
L
T
K
D
Y
I
W
V
V
D
E
S
K
M
V
D
T
L
G
-
A
-
F
R
L
P
V
E
V
V
Q
Y
G
A
E
R
L
F
R
E
F
E
----
K
K
G
------
Y
K
P
S
F
R
---
E
-
Y
--
D
G
V
R
--
F
V
T
D
M
K
N
F
I
I
D
L
D
L
G
S
I
P
D
P
I
A
F
G
N
M
L
D
H
Q
V
G
V
V
E
H
G
L
F
-
N
-
G
-
M
-
V
N
R
-
V
I
V
A
G
----
V
R
I
L
E
A
N
K
--
74
HHSearch
85.88
54%
-60
- C9 -
-
4GMK
-
?
A:
[5-227]
-
D
E
L
K
Q
L
V
G
T
K
A
V
E
W
----
I
K
D
----
G
M
I
V
G
L
G
T
G
S
T
V
K
Y
M
V
D
A
L
G
K
---
R
V
N
E
-
E
-
G
L
D
-
I
V
-
G
V
T
T
S
I
R
T
A
E
Q
A
K
S
L
G
I
V
I
K
D
I
D
E
V
D
H
I
D
L
T
I
D
G
A
D
E
I
-
S
S
-
D
F
Q
G
I
K
G
G
G
A
A
L
L
Y
E
K
I
V
A
T
K
S
N
K
N
M
W
I
V
D
E
S
K
M
V
D
D
L
G
-
Q
-
F
P
L
P
V
E
V
I
P
Y
G
S
G
T
V
F
K
R
F
E
----
E
K
G
------
L
N
P
E
F
R
---
K
-
N
E-
D
G
S
L
--
L
H
T
D
S
D
N
Y
I
I
D
L
H
L
G
K
I
E
N
P
K
E
L
G
D
Y
L
I
N
Q
V
G
V
V
E
H
G
L
F
-
L
-
D
-
I
-
V
N
T
-
V
I
V
G
R
Q
D
-
G
P
E
V
L
E
A
----
2
PsiBlast_PDB
85.12
53%
-58
- C9 -
-
4GMK
-
?
A:
[5-228]
-
D
E
L
K
Q
L
V
G
T
K
A
V
E
W
----
I
K
D
----
G
M
I
V
G
L
G
T
G
S
T
V
K
Y
M
V
D
A
L
G
K
---
R
V
N
E
-
E
-
G
L
D
-
I
V
-
G
V
T
T
S
I
R
T
A
E
Q
A
K
S
L
G
I
V
I
K
D
I
D
E
V
D
H
I
D
L
T
I
D
G
A
D
E
I
-
S
S
-
D
F
Q
G
I
K
G
G
G
A
A
L
L
Y
E
K
I
V
A
T
K
S
N
K
N
M
W
I
V
D
E
S
K
M
V
D
D
L
G
-
Q
-
F
P
L
P
V
E
V
I
P
Y
G
S
G
T
V
F
K
R
F
E
----
E
K
G
------
L
N
P
E
F
R
---
K
N
E
--
D
G
S
L
--
L
H
T
D
S
D
N
Y
I
I
D
L
H
L
G
K
I
E
N
P
K
E
L
G
D
Y
L
I
N
Q
V
G
V
V
E
H
G
L
F
-
L
-
D
-
I
-
V
N
T
-
V
I
V
G
R
Q
D
-
G
P
E
V
L
E
A
R
---
5
PsiBlast_PDB
80.24
37%
-86
- C9 -
-
3HHE
1
RPIA_BARHE
A:
[24-244]
V
Q
Q
L
K
K
M
A
A
L
K
A
L
E
F
----
V
E
D
----
D
M
R
L
G
I
G
S
G
S
T
V
N
E
F
I
P
L
L
G
E
---
R
V
A
N
---
G
L
R
-
V
T
-
C
V
A
T
S
Q
Y
S
E
Q
L
C
H
K
F
G
V
P
I
S
T
L
E
K
I
P
E
L
D
L
D
I
D
G
A
D
E
I
-
G
P
-
E
M
T
L
I
K
G
G
G
G
A
L
L
H
E
K
I
V
A
S
A
S
R
A
M
F
V
I
A
D
E
T
K
M
V
K
T
L
G
-
A
-
F
A
L
P
I
E
V
N
P
F
G
I
H
A
T
R
I
A
I
E
----
K
A
A
D
N
L
G
L
S
G
E
I
T
L
R
---
M
-
N
--
G
D
D
P
--
F
K
T
D
G
G
H
F
I
F
D
A
F
W
G
R
I
L
Q
P
K
L
L
S
E
A
L
L
A
I
P
G
V
V
E
H
G
L
F
-
L
-
G
-
L
-
A
S
R
-
A
I
V
A
M
A
D
------------
28
PsiBlast_CBE
79.12
37%
-88
- C9 -
-
3HHE
1
RPIA_BARHE
B:
[24-244]
V
Q
Q
L
K
K
M
A
A
L
K
A
L
E
F
----
V
E
D
----
D
M
R
L
G
I
G
S
G
S
T
V
N
E
F
I
P
L
L
G
E
---
R
V
A
N
---
G
L
R
-
V
T
-
C
V
A
T
S
Q
Y
S
E
Q
L
C
H
K
F
G
V
P
I
S
T
L
E
K
I
P
E
L
D
L
D
I
D
G
A
D
E
I
-
G
P
-
E
M
T
L
I
K
G
G
G
G
A
L
L
H
E
K
I
V
A
S
A
S
R
A
M
F
V
I
A
D
E
T
K
M
V
K
T
L
G
-
A
-
F
A
L
P
I
E
V
N
P
F
G
I
H
A
T
R
I
A
I
E
----
K
A
A
DNLGLS
G
E
I
T
L
R
---
M
-
N
--
G
D
D
P
--
F
K
T
D
G
G
H
F
I
F
D
A
F
W
G
R
I
L
Q
P
K
L
L
S
E
A
L
L
A
I
P
G
V
V
E
H
G
L
F
-
L
-
G
-
L
-
A
S
R
-
A
I
V
A
M
A
D
------------
75
HHSearch
78.59
38%
-83
- C9 -
-
3HHE
1
RPIA_BARHE
B:
[25-251]
-
Q
Q
L
K
K
M
A
A
L
K
A
L
E
F
----
V
E
D
----
D
M
R
L
G
I
G
S
G
S
T
V
N
E
F
I
P
L
L
G
E
---
R
V
A
N
-
G
--
L
R
-
V
T
-
C
V
A
T
S
Q
Y
S
E
Q
L
C
H
K
F
G
V
P
I
S
T
L
E
K
I
P
E
L
D
L
D
I
D
G
A
D
E
I
-
G
P
-
E
M
T
L
I
K
G
G
G
G
A
L
L
H
E
K
I
V
A
S
A
S
R
A
M
F
V
I
A
D
E
T
K
M
V
K
T
L
G
-
A
-
F
A
L
P
I
E
V
N
P
F
G
I
H
A
T
R
I
A
I
E
KAAD
N
L
G
LS----
G
E
I
T
L
R
---
M
-
N
--
G
D
D
P
--
F
K
T
D
G
G
H
F
I
F
D
A
F
W
G
R
I
L
Q
P
K
L
L
S
E
A
L
L
A
I
P
G
V
V
E
H
G
L
F
-
L
-
G
-
L
-
A
S
R
-
A
I
V
A
M
A
D
S
Q
I
K
V
L
E
-----
29
PsiBlast_CBE
77.10
42%
-43
- C9 -
-
3IXQ
4
RPIA_METJA
D:
[4-222]
-
E
D
L
K
L
K
V
A
K
E
A
V
K
L
----
V
K
D
----
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
---
R
I
R
E
-
E
-
E
L
T
-
V
F
-
G
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
D
-
V
D
I
A
F
D
G
A
D
E
V
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
L
G
E
K
-
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
----
E
M
G
------
G
E
A
V
I
R
---
L
-
G
--
D
R
K
R
GP
V
I
T
D
N
G
N
M
I
I
D
V
F
M
N
-
I
D
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
---
V
D
K
-
V
L
V
G
T
K
K
-
G
V
K
--------
30
PsiBlast_CBE
76.02
42%
-39
- C9 -
-
3IXQ
3
RPIA_METJA
C:
[4-222]
-
E
D
L
K
L
K
V
A
K
E
A
V
K
L
----
V
K
D
----
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
---
R
I
R
E
-
E
-
E
L
T
-
V
F
-
G
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
D
-
V
D
I
A
F
D
G
A
D
E
V
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
L
G
E
K
-
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
----
E
M
G
------
G
E
A
V
I
R
---
L
-
G
--
D
R
K
R
GP
V
I
T
D
N
G
N
M
I
I
D
V
F
M
N
-
I
D
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
---
V
D
K
-
V
L
V
G
T
K
K
-
G
V
K
--------
6
PsiBlast_PDB
75.85
42%
-40
- C9 -
-
3IXQ
4
RPIA_METJA
A:
[4-222]
-
E
D
L
K
L
K
V
A
K
E
A
V
K
L
----
V
K
D
----
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
---
R
I
R
E
-
E
-
E
L
T
-
V
F
-
G
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
D
-
V
D
I
A
F
D
G
A
D
E
V
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
L
G
E
K
-
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
----
E
M
G
------
G
E
A
V
I
R
---
L
-
G
--
D
R
K
R
GP
V
I
T
D
N
G
N
M
I
I
D
V
F
M
N
-
I
D
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
---
V
D
K
-
V
L
V
G
T
K
K
-
G
V
K
--------
79
HHSearch
75.68
37%
-96
- C9 -
-
1LKZ
-
RPIA_ECOLI
B:
[4-218]
-
D
E
L
K
K
A
V
G
W
A
A
L
Q
Y
----
V
Q
P
----
G
T
I
V
G
V
G
T
G
S
T
A
A
H
F
I
D
A
L
G
T
---
M
K
G
-----
Q
I
-
E
G
-
A
V
S
S
S
D
A
S
T
E
K
L
K
S
L
G
I
H
V
F
D
L
N
E
V
D
S
L
G
I
Y
V
D
G
A
D
E
I
-
N
G
-
H
M
Q
M
I
K
G
G
G
A
A
L
T
R
E
K
I
I
A
S
V
A
E
K
F
I
C
I
A
D
A
S
K
Q
V
D
I
L
G
-
K
-
F
P
L
P
V
E
V
I
P
M
A
R
S
A
V
A
R
Q
L
V
----
K
L
G
------
G
R
P
E
Y
R
---
Q
-------
G
--
V
V
T
D
N
G
N
V
I
L
D
V
H
G
M
E
I
L
D
P
I
A
M
E
N
A
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
N
-
R
G
A
D
V
-
A
L
I
G
T
P
D
-
G
V
K
T
I
V
-----
31
PsiBlast_CBE
74.62
42%
-42
- C9 -
-
3IXQ
4
RPIA_METJA
B:
[4-222]
-
E
D
L
K
L
K
V
A
K
E
A
V
K
L
----
V
K
D
----
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
---
R
I
R
E
-
E
-
E
L
T
-
V
F
-
G
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
D
-
V
D
I
A
F
D
G
A
D
E
V
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
L
G
E
K
-
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
----
E
M
G
------
G
E
A
V
I
R
---
L
-
G
--
D
R
K
R
GP
V
I
T
D
N
G
N
M
I
I
D
V
F
M
N
-
I
D
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
---
V
D
K
-
V
L
V
G
T
K
K
-
G
V
K
--------
82
HHSearch
74.59
42%
-36
- C9 -
-
3IXQ
3
RPIA_METJA
C:
[4-225]
-
E
D
L
K
L
K
V
A
K
E
A
V
K
L
----
V
K
D
----
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
---
R
I
R
E
-
E
-
E
L
T
-
V
F
-
G
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
-
Y
D
V
D
I
A
F
D
G
A
D
E
V
-
E
E
T
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
L
G
-
E
K
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
----
E
M
G
------
G
E
A
V
I
R
---
L
-
G
DR
K
R
G
P
--
V
I
T
D
N
G
N
M
I
I
D
V
F
M
N
-
I
D
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
---
V
D
K
-
V
L
V
G
T
K
K
-
G
V
K
T
L
K
-----
11
PsiBlast_PDB
74.41
37%
-91
- C9 -
-
1LKZ
-
RPIA_ECOLI
A:
[4-215]
-
D
E
L
K
K
A
V
G
W
A
A
L
Q
Y
----
V
Q
P
----
G
T
I
V
G
V
G
T
G
S
T
A
A
H
F
I
D
A
L
G
------
T
M
-
K
-
G
Q
I
-
E
G
-
A
V
S
S
S
D
A
S
T
E
K
L
K
S
L
G
I
H
V
F
D
L
N
E
V
D
S
L
G
I
Y
V
D
G
A
D
E
I
-
N
G
-
H
M
Q
M
I
K
G
G
G
A
A
L
T
R
E
K
I
I
A
S
V
A
E
K
F
I
C
I
A
D
A
S
K
Q
V
D
I
L
G
-
K
-
F
P
L
P
V
E
V
I
P
M
A
R
S
A
V
A
R
Q
L
V
----
K
L
G
------
G
R
P
E
Y
R
----------
Q
G
--
V
V
T
D
N
G
N
V
I
L
D
V
H
G
M
E
I
L
D
P
I
A
M
E
N
A
I
N
A
I
P
G
V
V
T
V
G
L
F
A
N
-
R
-
G
-
A
D
V
-
A
L
I
G
T
P
D
-
G
V
K
--------
13
PsiBlast_PDB
74.19
37%
-88
- C9 -
-
1KS2
-
RPIA_ECOLI
A:
[4-215]
-
D
E
L
K
K
A
V
G
W
A
A
L
Q
Y
----
V
Q
P
----
G
T
I
V
G
V
G
T
G
S
T
A
A
H
F
I
D
A
L
G
------
T
M
-
K
-
G
Q
I
-
E
G
-
A
V
S
S
S
D
A
S
T
E
K
L
K
S
L
G
I
H
V
F
D
L
N
E
V
D
S
L
G
I
Y
V
D
G
A
D
E
I
-
N
G
-
H
M
Q
M
I
K
G
G
G
A
A
L
T
R
E
K
I
I
A
S
V
A
E
K
F
I
C
I
A
D
A
S
K
Q
V
D
I
L
G
-
K
-
F
P
L
P
V
E
V
I
P
M
A
R
S
A
V
A
R
Q
L
V
----
K
L
G
------
G
R
P
E
Y
R
----------
Q
G
--
V
V
T
D
N
G
N
V
I
L
D
V
H
G
M
E
I
L
D
P
I
A
M
E
N
A
I
N
A
I
P
G
V
V
T
V
G
L
F
A
N
-
R
-
G
-
A
D
V
-
A
L
I
G
T
P
D
-
G
V
K
--------
85
HHSearch
73.55
35%
-77
- C9 -
-
4IO1
1
RPIA_FRATT
A:
[10-221]
-
D
E
L
K
K
L
A
A
T
E
A
A
K
S
----
I
T
T
----
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
E
E
L
V
N
---
Y
R
D
-----
K
I
-
K
T
-
V
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
L
G
-
N
-
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
----
K
L
G
------
G
Q
P
V
Y
R
---
E
-------
Q
--
T
I
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
-
A
-
L
K
P
-
A
D
T
-
V
I
M
A
T
K
D
-
S
N
I
--------
23
PsiBlast_CBE
71.89
41%
-11
- C9 -
-
1LK7
1
RPIA_PYRHO
C:
[3-225]
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
----
I
E
D
----
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
---
K
L
K
R
G
E
-
I
S
D
-
I
V
-
G
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
L
C
Q
K
-
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
S
----
I
F
N
------
A
K
A
E
L
R
MGV
N
-
K
--
D
G
P
---
V
I
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
-
I
-
A
D
I
-
V
I
V
G
T
R
E
-
G
V
K
--------
84
HHSearch
71.77
35%
-76
- C9 -
-
4M8L
15
RPIA_FRATW
A:
[10-221]
-
D
E
L
K
K
L
A
A
T
E
A
A
K
S
----
I
T
T
----
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
E
E
L
V
N
---
Y
R
D
-----
K
I
-
K
T
-
V
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
L
G
-
N
-
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
----
K
L
G
------
G
Q
P
V
Y
R
---
E
-------
Q
--
T
I
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
-
A
-
L
K
P
-
A
D
T
-
V
I
M
A
T
K
D
-
S
N
I
--------
83
HHSearch
71.53
38%
-59
* C9 *
-
1M0S
1
RPIA_HAEIN
B:
[4-218]
-
L
E
M
K
K
L
A
A
Q
A
A
L
Q
Y
----
V
K
A
----
D
R
I
V
G
V
G
S
G
S
T
V
N
C
F
I
E
A
L
G
T
---
I
K
D
-----
K
I
-
Q
G
-
A
V
A
A
S
K
E
S
E
E
L
L
R
K
Q
G
I
E
V
F
N
A
N
D
V
S
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
P
-
Q
K
M
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
L
A
K
K
F
I
C
I
V
D
S
S
K
Q
V
D
V
L
G
-
S
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Q
V
G
R
K
L
A
----
A
L
G
------
G
S
P
E
Y
R
---
E
-------
G
--
V
V
T
D
N
G
N
V
I
L
D
V
H
N
F
S
I
L
N
P
V
E
I
E
K
E
L
N
N
V
A
G
V
V
T
N
G
I
F
-
A
-
L
R
G
-
A
D
V
-
V
I
V
G
T
P
E
-
G
A
K
V
I
------
81
HHSearch
70.95
36%
-75
- C9 -
-
5UF2
10
RPIA_NEIG2
A:
[13-230]
-
D
E
L
K
R
I
A
A
E
K
A
V
E
F
----
V
P
E
----
N
E
Y
I
G
I
G
T
G
S
T
I
N
F
F
I
E
A
L
G
K
---
S
G
K
-----
K
I
-
K
G
-
A
V
S
T
S
K
K
S
G
E
L
L
A
R
Y
D
I
P
V
V
S
L
N
E
V
S
G
L
A
V
Y
I
D
G
A
D
E
V
-
N
H
-
A
L
Q
M
I
K
G
G
G
G
A
H
L
N
E
K
I
V
A
S
A
S
E
K
F
V
C
I
A
D
E
S
K
Y
V
S
R
L
G
-
K
-
F
P
L
P
V
E
A
V
E
S
A
R
S
L
V
S
R
K
L
L
----
A
M
G
------
G
Q
P
E
L
R
---
I
-------
G
--
Y
T
T
F
Y
G
N
Q
I
V
D
V
H
G
L
N
I
D
Q
P
L
T
M
E
D
E
I
N
K
I
T
G
V
L
E
N
G
I
F
-
A
-
R
-
D
-
A
A
D
V
L
I
L
G
T
E
E
-
G
A
K
V
I
Y
P
C
Q
--
24
PsiBlast_CBE
70.92
41%
-12
- C9 -
-
1LK7
1
RPIA_PYRHO
B:
[3-225]
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
----
I
E
D
----
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
---
K
L
K
R
G
E
-
I
S
D
-
I
V
-
G
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
L
C
Q
K
-
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
S
----
I
F
N
------
A
K
A
E
L
R
MGV
N
-
K
--
D
G
P
---
V
I
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
-
I
-
A
D
I
-
V
I
V
G
T
R
E
-
G
V
K
--------
22
PsiBlast_CBE
70.39
41%
-8
- C9 -
-
1LK7
1
RPIA_PYRHO
D:
[3-225]
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
----
I
E
D
----
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
---
K
L
K
R
G
E
-
I
S
D
-
I
V
-
G
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
L
C
Q
K
-
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
S
----
I
F
N
------
A
K
A
E
L
R
MGV
N
-
K
--
D
G
P
---
V
I
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
-
I
-
A
D
I
-
V
I
V
G
T
R
E
-
G
V
K
--------
8
PsiBlast_PDB
70.36
40%
-11
- C9 -
-
1UJ5
1
RPIA_THET2
A:
[5-223]
L
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
----
V
Q
D
----
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
---
R
L
R
E
-
G
-
E
L
K
G
V
V
-
G
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
-
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
L
G
-
R
-
G
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
----
D
L
G
------
G
E
P
E
L
R
---
M
-
D
--
G
D
E
F
--
Y
F
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
-
M
-
A
T
R
-
A
L
V
A
G
P
F
-
G
V
E
--------
10
PsiBlast_PDB
70.30
39%
-13
- C9 -
-
1UJ6
1
RPIA_THET2
A:
[5-223]
L
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
----
V
Q
D
----
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
---
R
L
R
E
-
G
-
E
L
K
G
V
V
-
G
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
-
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
L
G
-
R
-
G
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
----
D
L
G
------
G
E
P
E
L
R
---
M
-
D
--
G
D
E
F
--
Y
F
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
-
M
-
A
T
R
-
A
L
V
A
G
P
F
-
G
V
E
--------
4
PsiBlast_PDB
70.17
41%
-3
- C9 -
-
1LK7
1
RPIA_PYRHO
A:
[3-225]
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
----
I
E
D
----
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
---
K
L
K
R
G
E
-
I
S
D
-
I
V
-
G
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
L
C
Q
K
-
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
S
----
I
F
N
------
A
K
A
E
L
R
MGV
N
-
K
--
D
G
P
---
V
I
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
-
I
-
A
D
I
-
V
I
V
G
T
R
E
-
G
V
K
--------
71
HHSearch
69.80
40%
-10
- C9 -
-
1UJ5
1
RPIA_THET2
A:
[6-225]
-
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
----
V
Q
D
----
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
---
R
L
R
E
-
G
E
L
K
G
-
V
V
-
G
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
-
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
L
G
-
R
-
G
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
----
D
L
G
------
G
E
P
E
L
R
---
M
-
D
--
G
D
E
F
--
Y
F
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
-
M
-
A
T
R
-
A
L
V
A
G
P
F
-
G
V
E
E
L
------
72
HHSearch
69.75
40%
-11
- C9 -
-
1UJ6
1
RPIA_THET2
A:
[6-225]
-
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
----
V
Q
D
----
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
---
R
L
R
E
-
G
E
L
K
G
-
V
V
-
G
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
-
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
L
G
-
R
-
G
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
----
D
L
G
------
G
E
P
E
L
R
---
M
-
D
--
G
D
E
F
--
Y
F
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
-
M
-
A
T
R
-
A
L
V
A
G
P
F
-
G
V
E
E
L
------
68
HHSearch
69.53
40%
-13
- C9 -
-
1LK7
1
RPIA_PYRHO
B:
[4-228]
-
E
E
M
K
K
I
A
A
K
E
A
L
K
F
----
I
E
D
----
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
---
K
L
K
R
-
G
E
I
S
D
-
I
V
-
G
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
L
C
-
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
S
----
I
F
N
------
A
K
A
E
L
R
---
M
-
G
VN
K
D
G
P
--
V
I
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
-
I
-
A
D
I
-
V
I
V
G
T
R
E
-
G
V
K
K
L
E
-----
46
PsiBlast_CBE
69.52
37%
-54
- C9 -
-
1M0S
1
RPIA_HAEIN
B:
[6-217]
---
M
K
K
L
A
A
Q
A
A
L
Q
Y
----
V
K
A
----
D
R
I
V
G
V
G
S
G
S
T
V
N
C
F
I
E
A
L
G
T
----
I
K
D
-
K
-
I
Q
G
-
A
V
-
A
A
S
K
E
S
E
E
L
L
R
K
Q
G
I
E
V
--
F
N
A
N
D
V
S
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
P
-
Q
K
M
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
L
A
K
K
F
I
C
I
V
D
S
S
K
Q
V
D
V
L
G
-
S
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Q
V
G
R
K
L
A
----
A
L
G
------
G
S
P
E
Y
R
---
E
-
G
--------
V
V
T
D
N
G
N
V
I
L
D
V
H
N
F
S
I
L
N
P
V
E
I
E
K
E
L
N
N
V
A
G
V
V
T
N
G
I
F
-
A
L
R
-
G
-
A
D
V
-
V
I
V
G
T
P
E
-
G
A
K
V
-------
47
PsiBlast_CBE
68.81
37%
-49
- C9 -
-
1M0S
1
RPIA_HAEIN
A:
[6-217]
---
M
K
K
L
A
A
Q
A
A
L
Q
Y
----
V
K
A
----
D
R
I
V
G
V
G
S
G
S
T
V
N
C
F
I
E
A
L
G
T
----
I
K
D
-
K
-
I
Q
G
-
A
V
-
A
A
S
K
E
S
E
E
L
L
R
K
Q
G
I
E
V
--
F
N
A
N
D
V
S
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
P
-
Q
K
M
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
L
A
K
K
F
I
C
I
V
D
S
S
K
Q
V
D
V
L
G
-
S
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Q
V
G
R
K
L
A
----
A
L
G
------
G
S
P
E
Y
R
---
E
-
G
--------
V
V
T
D
N
G
N
V
I
L
D
V
H
N
F
S
I
L
N
P
V
E
I
E
K
E
L
N
N
V
A
G
V
V
T
N
G
I
F
-
A
L
R
-
G
-
A
D
V
-
V
I
V
G
T
P
E
-
G
A
K
V
-------
16
PsiBlast_PDB
65.28
37%
-3
- C9 -
-
3ENV
1
RPIA_VIBVY
A:
[21-233]
-
D
E
M
K
K
A
A
G
W
A
A
L
K
Y
----
V
E
K
----
G
S
I
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
---
M
S
E
E
I
K
-
G
------
A
V
S
S
S
V
A
S
T
E
K
L
E
A
L
G
I
K
I
F
D
C
N
E
V
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
L
G
-
T
-
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
----
K
L
G
------
G
D
P
C
Y
R
---
E
-
G
--------
V
I
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
A
H
-
R
-
G
-
A
D
V
-
V
I
T
G
T
P
E
-
G
A
K
I
-------
70
HHSearch
64.74
37%
20
- C9 -
-
3UW1
1
?
A:
[12-237]
-
D
E
L
K
R
L
V
G
E
A
A
A
R
Y
V
T
D
N
V
P
Q
----
G
A
V
I
G
V
G
T
G
S
T
A
N
C
F
I
D
A
L
A
A
---
V
K
D
-----
R
Y
-
R
G
-
A
V
S
S
S
V
A
T
T
E
R
L
K
S
H
G
I
R
V
F
D
L
N
E
I
E
S
L
Q
V
Y
V
D
G
A
D
E
I
-
D
E
-
S
G
A
M
I
K
G
G
G
G
A
L
T
R
E
K
I
V
A
S
V
A
E
T
F
V
C
I
A
D
A
S
K
R
V
A
M
L
G
-
Q
-
F
P
L
P
V
E
V
V
P
M
A
R
T
A
I
G
R
R
L
A
----
A
L
G
------
G
V
P
V
L
R
---
V
-
K
Q-
D
G
T
P
--
Y
V
T
D
N
G
N
E
I
L
D
V
K
G
L
R
I
D
D
P
R
A
L
E
A
A
I
N
G
W
P
G
V
V
T
V
G
L
F
-
A
-
Q
R
G
-
A
D
L
-
C
L
L
G
T
E
H
-
G
V
E
T
L
R
Y
A
---
17
PsiBlast_PDB
64.50
37%
-3
- C9 -
-
3ENW
1
RPIA_VIBVY
A:
[21-233]
-
D
E
M
K
K
A
A
G
W
A
A
L
K
Y
----
V
E
K
----
G
S
I
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
---
M
S
E
E
I
K
-
G
------
A
V
S
S
S
V
A
S
T
E
K
L
E
A
L
G
I
K
I
F
D
C
N
E
V
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
L
G
-
T
-
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
----
K
L
G
------
G
D
P
C
Y
R
---
E
-
G
--------
V
I
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
A
H
-
R
-
G
-
A
D
V
-
V
I
T
G
T
P
E
-
G
A
K
I
-------
80
HHSearch
64.35
37%
-83
- C9 -
-
1O8B
1
RPIA_ECOLI
A:
[23-218]
----------------------------
I
V
G
V
G
T
G
S
T
------------------------
E
G
-
A
V
S
S
S
D
A
------------
F
D
L
N
E
V
D
S
L
G
I
Y
V
D
G
A
D
E
I
-
N
G
-
H
M
Q
M
I
K
G
G
G
-
A
L
T
R
E
K
I
I
A
S
V
A
E
K
F
I
C
I
A
D
A
S
K
Q
V
D
I
L
G
-
K
-
F
P
L
P
V
E
V
I
P
M
A
R
S
A
V
A
R
Q
L
V
----
K
L
G
------
G
R
P
E
Y
R
---
Q
-------
G
--
V
V
T
D
N
G
N
V
I
L
D
V
H
G
M
E
I
L
D
P
I
A
M
E
N
A
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
N
-
R
G
A
D
V
-
A
L
I
G
T
P
D
-
G
V
K
T
I
V
-----
33
PsiBlast_CBE
63.59
37%
-3
- C9 -
-
3ENW
1
RPIA_VIBVY
B:
[21-233]
-
D
E
M
K
K
A
A
G
W
A
A
L
K
Y
----
V
E
K
----
G
S
I
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
---
M
S
E
E
I
K
-
G
------
A
V
S
S
S
V
A
S
T
E
K
L
E
A
L
G
I
K
I
F
D
C
N
E
V
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
L
G
-
T
-
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
----
K
L
G
------
G
D
P
C
Y
R
---
E
-
G
--------
V
I
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
A
H
-
R
-
G
-
A
D
V
-
V
I
T
G
T
P
E
-
G
A
K
I
-------
12
PsiBlast_PDB
63.34
37%
-78
- C9 -
-
1O8B
1
RPIA_ECOLI
A:
[23-215]
----------------------------
I
V
G
V
G
T
G
S
T
------------------------
E
G
-
A
V
S
S
S
D
A
------------
F
D
L
N
E
V
D
S
L
G
I
Y
V
D
G
A
D
E
I
-
N
G
-
H
M
Q
M
I
K
G
G
G
-
A
L
T
R
E
K
I
I
A
S
V
A
E
K
F
I
C
I
A
D
A
S
K
Q
V
D
I
L
G
-
K
-
F
P
L
P
V
E
V
I
P
M
A
R
S
A
V
A
R
Q
L
V
----
K
L
G
------
G
R
P
E
Y
R
----------
Q
G
--
V
V
T
D
N
G
N
V
I
L
D
V
H
G
M
E
I
L
D
P
I
A
M
E
N
A
I
N
A
I
P
G
V
V
T
V
G
L
F
A
N
-
R
-
G
-
A
D
V
-
A
L
I
G
T
P
D
-
G
V
K
--------
34
PsiBlast_CBE
62.33
37%
-5
- C9 -
-
3ENV
1
RPIA_VIBVY
B:
[21-233]
-
D
E
M
K
K
A
A
G
W
A
A
L
K
Y
----
V
E
K
----
G
S
I
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
---
M
S
E
E
I
K
-
G
------
A
V
S
S
S
V
A
S
T
E
K
L
E
A
L
G
I
K
I
F
D
C
N
E
V
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
L
G
-
T
-
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
----
K
L
G
------
G
D
P
C
Y
R
---
E
-
G
--------
V
I
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
A
H
-
R
-
G
-
A
D
V
-
V
I
T
G
T
P
E
-
G
A
K
I
-------
14
PsiBlast_PDB
59.83
36%
-4
- C9 -
-
5UF2
10
RPIA_NEIG2
A:
[13-220]
-
D
E
L
K
R
I
A
A
E
K
A
V
E
F
----
V
P
E
----
N
E
Y
I
G
I
G
T
G
S
T
I
N
F
F
I
E
A
L
G
K
--------
S
-
G
K
K
-
I
K
G
A
V
S
T
S
K
K
S
G
E
L
L
A
R
Y
D
I
P
V
V
S
L
N
E
V
S
G
L
A
V
Y
I
D
G
A
D
E
V
-
N
H
-
A
L
Q
M
I
K
G
G
G
G
A
H
L
N
E
K
I
V
A
S
A
S
E
K
F
V
C
I
A
D
E
S
K
Y
V
S
R
L
G
-
K
-
F
P
L
P
V
E
A
V
E
S
A
R
S
L
V
S
R
K
L
L
----
A
M
G
------
G
Q
P
E
L
R
----------
I
G
--
Y
T
T
F
Y
G
N
Q
I
V
D
V
H
G
L
N
I
D
Q
P
L
T
M
E
D
E
I
N
K
I
T
G
V
L
E
N
G
I
F
-
A
-
R
-
D
-
A
A
D
-
V
L
I
L
G
T
E
------------
39
PsiBlast_CBE
58.34
34%
11
- C9 -
-
3KWM
1
RPIA_FRATT
D:
[12-219]
---
L
K
K
L
A
A
T
E
A
A
K
S
----
I
T
T
----
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
E
E
L
V
N
YRD
K
I
K
---------
T
-
V
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
L
G
-
N
-
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
----
K
L
G
------
G
Q
P
V
Y
R
---
E
-
Q
--
T
------
I
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
-
A
L
K
-
P
-
A
D
T
-
V
I
M
A
T
K
D
-
S
----------
40
PsiBlast_CBE
58.07
34%
12
- C9 -
-
3KWM
4
RPIA_FRATT
C:
[12-219]
---
L
K
K
L
A
A
T
E
A
A
K
S
----
I
T
T
----
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
E
E
L
V
N
YRD
K
I
K
---------
T
-
V
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
L
G
-
N
-
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
----
K
L
G
------
G
Q
P
V
Y
R
---
E
-
Q
--
T
------
I
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
-
A
L
K
-
P
-
A
D
T
-
V
I
M
A
T
K
D
-
S
----------
20
PsiBlast_PDB
56.95
34%
16
- C9 -
-
4M8L
15
RPIA_FRATW
A:
[12-219]
---
L
K
K
L
A
A
T
E
A
A
K
S
----
I
T
T
----
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
E
E
L
V
N
YRD
K
I
K
---------
T
-
V
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
L
G
-
N
-
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
----
K
L
G
------
G
Q
P
V
Y
R
---
E
-
Q
--
T
------
I
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
-
A
L
K
-
P
-
A
D
T
-
V
I
M
A
T
K
D
-
S
----------
48
PsiBlast_CBE
56.67
38%
26
- C9 -
-
3UW1
1
?
A:
[12-217]
-
D
E
L
K
R
L
V
G
E
A
A
A
R
Y
----
V
T
D
NVPQ
G
A
V
I
G
V
G
T
G
S
T
A
N
C
F
I
D
A
L
A
A
----
V
K
D
-
R
---
Y
-
R
G
-
A
V
S
S
S
V
A
T
T
E
R
L
K
S
H
G
I
R
V
F
D
L
N
E
I
E
S
L
Q
V
Y
V
D
G
A
D
E
I
-
D
E
-
S
G
A
M
I
K
G
G
G
G
A
L
T
R
E
K
I
V
A
S
V
A
E
T
F
V
C
I
A
D
A
S
K
R
V
A
M
L
G
-
Q
-
F
P
L
P
V
E
V
V
P
M
A
R
T
A
I
G
R
R
L
A
----
A
L
G
------
G
V
P
V
L
R
---
V
-
K
Q-
D
G
T
P
--
Y
V
T
D
N
G
N
E
I
L
D
V
K
G
L
R
I
D
D
P
R
A
L
E
A
A
I
N
G
W
P
G
V
V
T
V
G
L
F
-
A
-
Q
--------------------------
37
PsiBlast_CBE
56.38
34%
18
- C9 -
-
4M8L
5
RPIA_FRATW
B:
[12-219]
---
L
K
K
L
A
A
T
E
A
A
K
S
----
I
T
T
----
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
E
E
L
V
N
YRD
K
I
K
---------
T
-
V
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
L
G
-
N
-
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
----
K
L
G
------
G
Q
P
V
Y
R
---
E
-
Q
--
T
------
I
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
-
A
L
K
-
P
-
A
D
T
-
V
I
M
A
T
K
D
-
S
----------
49
PsiBlast_CBE
55.30
38%
21
- C9 -
-
3U7J
5
?
A:
[12-217]
-
D
E
L
K
R
L
V
G
E
A
A
A
R
Y
----
V
T
D
NVPQ
G
A
V
I
G
V
G
T
G
S
T
A
N
C
F
I
D
A
L
A
A
----
V
K
D
-
R
---
Y
-
R
G
-
A
V
S
S
S
V
A
T
T
E
R
L
K
S
H
G
I
R
V
F
D
L
N
E
I
E
S
L
Q
V
Y
V
D
G
A
D
E
I
-
D
E
-
S
G
A
M
I
K
G
G
G
G
A
L
T
R
E
K
I
V
A
S
V
A
E
T
F
V
C
I
A
D
A
S
K
R
V
A
M
L
G
-
Q
-
F
P
L
P
V
E
V
V
P
M
A
R
T
A
I
G
R
R
L
A
----
A
L
G
------
G
V
P
V
L
R
---
V
-
K
Q-
D
G
T
P
--
Y
V
T
D
N
G
N
E
I
L
D
V
K
G
L
R
I
D
D
P
R
A
L
E
A
A
I
N
G
W
P
G
V
V
T
V
G
L
F
-
A
-
Q
--------------------------