@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0734: (2017-12-28 )
MTFLNKIHETATFLKEKGIAAPEFGLILGSGLGELAEEIENPVVVDYAEIPNWGRSTVVGHAGKLVYGELAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKVLGCEGVIVTNAAGGIGFGPGTLMAISDHINMTGQNPLMGENLDDFGPRFPDMSRAYTPEYRATAHEVAKKLNIKLDEGVYIGVTGPTYETPAEIRSYKTLGADAVGMSTVPEVIVAAHSGLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGDFKGLLKAILAEL
Atome Classification :
(72 SA)
.........10.......------.20........30........40--..-.......50........60........70........80........90........100...-....110.....--.--.120.......130.---.---.---.---...140.......150.......160.......170.--..--.--...180.......190.......200.......210.......220.......230.---......--------------240---.......250.......260.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
F
L
N
K
I
H
E
T
A
T
F
L
K
EKG------IAAP
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
IE---N
P
-
V
V
V
D
YAEIPNWGRSTVVGHAG
K
L
V
Y
GELAG
R
K
V
L
A
LQ
G
R
F
H
FYEGN
P
L
E
V
V
T
F
P
V
R
V
M
K
V
LGC-E
G
V
I
V
TNAAGGI--G--FGPG
T
L
M
A
I
S
DHINM---T---G---Q---NPLMGEN
L
D
DFGPRFPDMSRAYTP
E
Y
R
A
T
A
H
E
V
A
K
KL--N
I
--
K
--LDE
G
V
Y
I
G
VTGPTYE
T
P
A
E
I
R
S
Y
KTLGADAVG
M
S
T
V
P
E
V
I
V
A
A
HSG
L
K
V
L
G
I
S
C
I
T
N
---
F
A
A
G
F
Q
--------------
E
EL---
N
H
E
E
V
V
E
V
T
E
R
V
K
G
D
F
K
G
L
L
K
A
I
L
AEL
128
HHSearch
96.63
80%
-126
- C4 -
-
3LBA
1
?
A:
[35-303]
M
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
------
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
---
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
-
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
L
---
T
---
G
---
A
---
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
G
F
Q
--------------
S
E
L
---
N
---
V
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
2
PsiBlast_PDB
96.34
79%
-126
- C4 -
-
3LBA
1
?
A:
[35-303]
M
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
------
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
---
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
-
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
L
---
T
---
G
---
A
---
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
G
F
Q
--------------
S
E
L
---
N
---
V
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
127
HHSearch
94.26
80%
-139
- C4 -
-
3LA8
-
?
A:
[36-303]
-
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
------
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
---
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
-
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
L
---
T
---
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
G
F
--------------------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
1
PsiBlast_PDB
93.99
79%
-139
- C4 -
-
3LA8
-
?
A:
[36-303]
-
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
------
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
---
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
-
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
L
---
T
---
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
G
F
--------------------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
131
HHSearch
81.34
49%
-81
- C4 -
-
4NSN
1
?
C:
[25-295]
-
L
Q
E
Q
H
Y
H
E
A
A
S
F
L
S
S
R
L
------
P
G
D
A
K
T
A
I
I
L
G
S
G
L
G
E
L
A
E
K
I
E
---
N
K
-
T
V
I
P
Y
N
E
I
P
H
F
A
Q
A
T
A
V
G
H
K
G
N
I
I
G
G
I
L
G
G
T
P
V
V
A
M
Q
G
R
F
H
Y
Y
E
G
Y
S
M
D
Q
V
T
F
P
I
R
V
M
K
L
L
G
I
-
E
N
L
F
V
S
N
A
A
G
G
I
--
N
TS
F
K
V
G
D
L
M
I
I
C
D
H
I
N
N
---
L
---
P
-------
N
P
L
I
G
P
N
M
D
M
F
G
V
R
F
P
D
M
T
R
A
Y
D
R
E
F
I
A
K
A
K
G
I
A
Q
E
L
--
N
I
--
P
--
V
K
E
G
V
Y
V
G
L
T
G
P
S
Y
E
T
P
A
E
Y
K
F
W
G
Q
V
G
G
D
A
I
G
M
S
T
V
P
E
V
I
V
A
R
H
T
G
I
R
V
F
G
M
S
V
I
T
N
---
E
G
Y
H
F
A
DD------------
F
V
N
---
D
E
Q
D
V
I
R
A
A
N
A
A
S
E
K
M
G
A
I
F
A
R
L
I
A
A
V
125
HHSearch
81.03
45%
-82
- C4 -
-
4M1E
3
?
D:
[25-295]
-
E
L
K
S
R
I
D
Q
A
T
A
K
I
S
Q
L
W
------
Q
G
E
P
A
V
G
M
I
L
G
T
G
L
G
G
L
A
E
Q
I
E
---
Q
D
-
I
A
I
P
Y
S
D
I
P
H
F
P
T
S
T
V
K
S
H
A
G
R
L
V
C
G
R
L
R
G
I
P
I
V
A
M
E
G
R
F
H
Y
Y
E
G
Y
S
L
E
Q
V
T
F
P
V
R
V
M
K
A
M
G
V
-
K
T
L
L
V
T
N
A
A
G
G
I
--
N
PQ
L
D
L
S
D
V
L
I
I
E
D
H
I
N
L
---
M
---
P
---
E
---
N
P
L
R
G
P
N
D
E
E
L
G
P
R
F
P
D
M
S
H
P
Y
D
C
Q
H
M
E
V
A
R
Q
V
A
L
E
L
--
G
I
--
H
--
C
P
K
G
V
F
V
A
V
S
G
P
N
L
E
T
R
A
E
Y
R
M
L
K
L
M
G
A
D
V
V
G
M
S
T
V
P
E
V
L
V
A
V
H
A
G
L
R
V
L
G
F
S
V
V
T
D
---
L
C
L
P
D
A
L-------------
E
P
V
---
E
L
N
K
I
L
E
V
A
A
R
G
G
A
K
L
A
R
L
I
P
E
I
L
P
R
I
126
HHSearch
80.97
45%
-83
- C4 -
-
4M1E
3
?
A:
[25-295]
-
E
L
K
S
R
I
D
Q
A
T
A
K
I
S
Q
L
W
------
Q
G
E
P
A
V
G
M
I
L
G
T
G
L
G
G
L
A
E
Q
I
E
---
Q
D
-
I
A
I
P
Y
S
D
I
P
H
F
P
T
S
T
V
K
S
H
A
G
R
L
V
C
G
R
L
R
G
I
P
I
V
A
M
E
G
R
F
H
Y
Y
E
G
Y
S
L
E
Q
V
T
F
P
V
R
V
M
K
A
M
G
V
-
K
T
L
L
V
T
N
A
A
G
G
I
--
N
PQ
L
D
L
S
D
V
L
I
I
E
D
H
I
N
L
---
M
---
P
---
E
---
N
P
L
R
G
P
N
D
E
E
L
G
P
R
F
P
D
M
S
H
P
Y
D
C
Q
H
M
E
V
A
R
Q
V
A
L
E
L
--
G
I
--
H
--
C
P
K
G
V
F
V
A
V
S
G
P
N
L
E
T
R
A
E
Y
R
M
L
K
L
M
G
A
D
V
V
G
M
S
T
V
P
E
V
L
V
A
V
H
A
G
L
R
V
L
G
F
S
V
V
T
D
---
L
C
L
P
D
A
L-------------
E
P
V
---
E
L
N
K
I
L
E
V
A
A
R
G
G
A
K
L
A
R
L
I
P
E
I
L
P
R
I
82
PsiBlast_CBE
77.78
47%
-71
- C4 -
-
4EB8
3
PNPH_HUMAN
B:
[48-317]
---------
T
A
E
Y
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
33
PsiBlast_CBE
77.69
48%
-76
- C4 -
-
3K8O
1
PNPH_HUMAN
Y:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
-
L
M
A
S
I
122
HHSearch
77.25
43%
-74
- C4 -
-
2P4S
2
?
C:
[90-367]
-
Y
T
Y
D
T
L
Q
E
I
A
T
Y
L
L
E
R
T
------
E
L
R
P
K
V
G
I
I
C
G
S
G
L
G
T
L
A
E
Q
L
T
---
D
V
-
D
S
F
D
Y
E
T
I
P
H
F
P
V
S
T
V
A
G
H
V
G
R
L
V
F
G
Y
L
A
G
V
P
V
M
C
M
Q
G
R
F
H
H
Y
E
G
Y
P
L
A
K
C
A
M
P
V
R
V
M
H
L
I
G
C
-
T
H
L
I
A
T
N
A
A
G
G
A
--
N
PK
Y
R
V
G
D
I
M
L
I
K
D
H
I
N
L
---
M
---
G
FAG
N
---
N
P
L
Q
G
P
N
D
E
R
F
G
P
R
F
F
G
M
A
N
T
Y
D
P
K
L
N
Q
Q
A
K
V
I
A
R
Q
I
--
G
I
EN
E
--
L
R
E
G
V
Y
T
C
L
G
G
P
N
F
E
T
V
A
E
V
K
M
L
S
M
L
G
V
D
A
I
G
M
S
T
V
H
E
I
I
T
A
R
H
C
G
M
T
C
F
A
F
S
L
I
T
N
---
M
C
T
M
S
Y
EEE-----------
E
E
H
---
C
H
D
S
I
V
G
V
G
K
N
R
E
K
T
L
G
E
F
V
S
R
I
V
K
H
I
20
PsiBlast_PDB
77.17
48%
-67
- C4 -
-
3K8O
2
PNPH_HUMAN
E:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
130
HHSearch
77.00
44%
-85
- C4 -
-
4LNA
2
?
A:
[22-293]
-
S
M
F
E
Q
I
Q
E
T
T
Q
F
I
Q
S
K
I
------
T
L
R
P
A
I
G
I
I
L
G
T
G
L
G
A
L
T
N
E
L
D
---
I
D
-
T
T
I
P
Y
E
T
I
P
H
F
P
L
S
T
V
---
S
G
K
L
L
I
G
T
L
G
G
K
S
V
V
V
M
Q
G
R
F
H
Y
Y
E
G
Y
T
M
Q
Q
V
T
Y
P
V
R
V
M
H
A
L
G
I
-
Q
T
L
L
V
S
N
A
A
G
G
M
--
N
PT
F
Q
T
S
D
L
M
V
I
D
D
H
I
S
L
---
L
L--
P
---
Q
---
N
P
L
I
C
P
N
P
P
I
F
G
D
R
F
P
D
M
S
E
P
Y
R
K
S
L
I
D
L
A
F
S
V
A
A
E
L
--
D
I
--
P
--
L
K
R
G
V
Y
V
S
V
T
G
P
Q
L
E
T
R
A
E
Y
R
M
L
R
Q
W
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
N
Q
L
G
M
D
V
F
G
I
S
V
I
T
D
---
L
C
F
P
D
T
L-------------
E
K
A
---
E
L
V
K
I
L
A
T
A
A
Q
A
E
P
K
L
T
M
L
I
R
E
M
I
G
R
L
121
HHSearch
76.92
48%
-62
- C4 -
-
5UGF
2
?
C:
[36-313]
-
Y
T
Y
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
---
P
---
G
F
S
G
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
Y
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
--
G
E
QR
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
ESL-----------
E
K
A
---
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
26
PsiBlast_CBE
76.82
47%
-69
- C4 -
-
1LVU
2
PNPH_BOVIN
B:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
Y
E
-----------------------
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
56
PsiBlast_CBE
76.65
48%
-68
- C4 -
-
3PHB
2
PNPH_HUMAN
E:
[48-317]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
52
PsiBlast_CBE
76.63
48%
-67
- C4 -
-
3PHB
2
PNPH_HUMAN
U:
[48-317]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
54
PsiBlast_CBE
76.56
48%
-65
- C4 -
-
3PHB
2
PNPH_HUMAN
S:
[48-317]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
51
PsiBlast_CBE
76.56
48%
-67
- C4 -
-
3PHB
2
PNPH_HUMAN
Y:
[48-317]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
34
PsiBlast_CBE
76.52
48%
-67
- C4 -
-
3K8O
2
PNPH_HUMAN
U:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
133
HHSearch
76.40
47%
-63
* C4 *
-
3FUC
2
PNPH_BOVIN
A:
[4-282]
G
Y
T
Y
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
--
N
PN
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
---
P
---
G
F
S
G
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
--
G
E
Q
R
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
ESQ-----------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
81
PsiBlast_CBE
76.40
47%
-70
- C4 -
-
4EB8
2
PNPH_HUMAN
C:
[48-317]
---------
T
A
E
Y
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
9
PsiBlast_PDB
75.64
47%
-49
- C4 -
-
1A9T
2
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
47
PsiBlast_CBE
75.62
47%
-49
- C4 -
-
1A9S
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
59
PsiBlast_CBE
75.53
47%
-58
- C4 -
-
3FUC
2
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
92
PsiBlast_CBE
75.50
47%
-67
- C4 -
-
2ON6
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
----
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
F
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
61
PsiBlast_CBE
75.42
47%
-54
- C4 -
-
1B8N
1
PNPH_BOVIN
A:
[11-279]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
---
60
PsiBlast_CBE
75.34
47%
-52
- C4 -
-
1B8O
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
8
PsiBlast_PDB
75.21
47%
-52
- C4 -
-
1A9R
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
94
PsiBlast_CBE
75.16
47%
-78
- C4 -
-
3GGS
2
PNPH_HUMAN
C:
[35-304]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
7
PsiBlast_PDB
75.16
47%
-51
- C4 -
-
1A9Q
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
T
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
83
PsiBlast_CBE
75.14
47%
-63
- C4 -
-
4EB8
2
PNPH_HUMAN
A:
[48-317]
---------
T
A
E
Y
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
58
PsiBlast_CBE
75.11
47%
-57
- C4 -
-
3FUC
2
PNPH_BOVIN
B:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
57
PsiBlast_CBE
75.11
47%
-54
- C4 -
-
3FUC
2
PNPH_BOVIN
C:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
17
PsiBlast_PDB
75.10
48%
-64
- C4 -
-
3BGS
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
93
PsiBlast_CBE
74.79
47%
-63
- C4 -
-
2A0X
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
F
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
64
PsiBlast_CBE
74.58
47%
-54
- C4 -
-
2AI1
2
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
3
PsiBlast_PDB
74.57
47%
-48
- C4 -
-
1FXU
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
-----------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
32
PsiBlast_CBE
74.50
48%
-66
- C4 -
-
3K8Q
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
48
PsiBlast_CBE
74.48
47%
-47
- C4 -
-
1A9P
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
19
PsiBlast_PDB
74.42
48%
-70
- C4 -
-
3D1V
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
41
PsiBlast_CBE
74.35
48%
-65
- C4 -
-
1V3Q
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
100
PsiBlast_CBE
74.31
47%
-64
- C4 -
-
2A0W
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
G
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
13
PsiBlast_PDB
74.25
48%
-61
- C4 -
-
1RT9
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
12
PsiBlast_PDB
74.23
48%
-62
- C4 -
-
1RSZ
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
18
PsiBlast_PDB
74.21
48%
-63
- C4 -
-
2Q7O
1
PNPH_HUMAN
E:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
63
PsiBlast_CBE
74.16
47%
-53
- C4 -
-
2AI2
2
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
99
PsiBlast_CBE
74.15
47%
-66
- C4 -
-
2OC9
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
------
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
G
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
44
PsiBlast_CBE
74.12
48%
-62
- C4 -
-
1RCT
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
11
PsiBlast_PDB
73.98
48%
-61
- C4 -
-
1RR6
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
10
PsiBlast_PDB
73.98
48%
-59
- C4 -
-
1PF7
1
PNPH_HUMAN
E:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
84
PsiBlast_CBE
73.95
47%
-62
- C4 -
-
2OC4
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
D
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
85
PsiBlast_CBE
73.79
47%
-59
- C4 -
-
2A0Y
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
D
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
40
PsiBlast_CBE
73.33
48%
-58
- C4 -
-
1V41
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
62
PsiBlast_CBE
73.26
47%
-50
- C4 -
-
2AI3
2
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
Y
------------------
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
96
PsiBlast_CBE
73.17
47%
-74
- C4 -
-
3GGS
2
PNPH_HUMAN
A:
[35-304]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
14
PsiBlast_PDB
73.12
48%
-62
- C4 -
-
1YRY
1
PNPH_HUMAN
E:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
124
HHSearch
73.09
42%
-68
- C4 -
-
3KHS
2
?
B:
[1-279]
M
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
------
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
---
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
-
K
I
V
V
L
T
N
A
A
G
G
L
--
N
PS
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
---
P
G
L
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
---
V
I
A
S
N
C
E----------------------
E
V
L
R
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
43
PsiBlast_CBE
73.09
48%
-60
- C4 -
-
1RFG
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
38
PsiBlast_CBE
73.01
48%
-64
- C4 -
-
3INY
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
65
PsiBlast_CBE
72.84
47%
-73
- C4 -
-
1V48
1
PNPH_BOVIN
A:
[11-282]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
E
---------------------------------
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
39
PsiBlast_CBE
72.66
48%
-60
- C4 -
-
1V45
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
42
PsiBlast_CBE
72.28
48%
-60
- C4 -
-
1V2H
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
45
PsiBlast_CBE
71.99
48%
-59
- C4 -
-
1PWY
1
PNPH_HUMAN
E:
[12-281]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
PGF
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
EKA
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
16
PsiBlast_PDB
71.32
48%
-61
- C4 -
-
1ULB
1
PNPH_HUMAN
A:
[13-282]
---------
T
A
E
W
L
L
S
H
T
------
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
---
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
-
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
M
D
Y
--------------
E
S
L
E
K
A
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
21
PsiBlast_CBE
71.19
49%
-93
- C4 -
-
1VMK
1
?
C:
[19-270]
--------
E
A
R
T
F
I
S
E
R
T
------
N
L
S
P
D
I
L
I
I
L
G
-----
F
I
E
K
V
E
---
D
P
-
V
I
I
D
Y
K
D
I
P
H
F
P
--------
G
K
L
V
F
G
R
I
S
D
K
P
V
M
I
M
A
G
R
F
H
L
Y
E
G
H
D
P
A
T
V
A
F
P
V
Y
L
A
K
Y
V
G
V
-
K
G
V
V
V
T
N
A
A
G
A
I
--
N
PE
F
K
P
G
E
I
I
L
V
R
D
I
I
N
F
---
M
---
F
---
R
---
N
P
L
R
G
P
N
D
E
K
I
G
P
R
F
P
D
M
S
S
V
V
D
P
E
W
---
A
R
K
I
Q
E
R
L
--
S
L
--
K
----
E
G
V
Y
I
G
V
L
G
P
S
Y
E
T
P
A
E
I
R
V
F
E
K
L
G
A
D
L
V
G
M
S
T
V
P
E
V
I
A
A
K
H
C
G
L
K
V
V
V
F
S
C
V
T
N
---
M
A
A
G
I
T
---------------------------
T
T
K
M
A
Q
G
K
I
E
K
A
L
-------
135
HHSearch
71.08
40%
-72
- C4 -
-
1TCV
2
?
A:
[7-284]
-
A
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
------
S
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
---
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
-
K
I
L
M
V
S
N
A
A
G
G
L
--
N
RS
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
L
---
P
---
G
---
L
G
LN
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
--
G
F
GN
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
V
ESD-------------------------
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
4
PsiBlast_PDB
71.01
47%
-48
- C4 -
-
1VFN
1
PNPH_BOVIN
A:
[8-279]
-------
Q
D
T
A
K
W
L
L
S
H
T
------
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
---
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
-------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
-
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
---
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
--
S
Q
--------------
G
K
A
---
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
123
HHSearch
70.14
42%
-69
- C4 -
-
3KHS
1
?
D:
[1-279]
M
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
------
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
---
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-------
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
-
K
I
V
V
L
T
N
A
A
G
G
L
--
N
PS
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
---
P
GLA
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
---
V
I
A
S
N
C
E--------------------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
141
HHSearch
68.95
43%
-29
- C4 -
-
5IFK
1
?
B:
[8-306]
-
E
Q
R
A
L
I
K
S
A
H
R
Y
I
S
E
K
L
E
D
H
F
S
S
E
F
L
P
K
A
L
V
I
C
G
S
G
L
S
G
I
S
T
K
I
A
DEP
K
P
-
L
I
L
S
Y
S
T
I
P
G
F
---------
G
E
L
I
F
G
Y
M
N
G
A
P
V
V
L
M
N
G
R
L
H
S
Y
E
G
H
S
L
A
E
T
V
H
P
I
R
A
L
H
L
L
G
S
I
N
V
L
I
V
T
N
A
A
G
G
I
--
N
AS
F
K
A
G
D
L
M
C
V
Y
D
H
I
N
F
---
P
---
G
---
L
C
GF
H
P
L
R
G
A
N
F
D
E
F
G
P
R
F
L
A
T
S
D
A
Y
D
L
E
L
R
K
L
L
F
S
K
K
K
E
L
--
N
I
ER
K
--
I
H
E
G
T
Y
S
Y
V
H
G
P
T
F
E
S
R
A
E
S
R
F
L
R
L
A
G
T
D
A
V
G
M
S
T
V
P
E
V
V
T
A
R
H
C
G
W
R
V
L
A
L
S
L
I
T
N
---
E
C
V
V
D
P
PASAHDENPVPIQE
G
K
A
---
T
H
E
E
V
L
E
N
S
A
K
A
S
K
D
V
Q
E
L
I
F
S
V
V
A
E
I
140
HHSearch
68.95
43%
-33
- C4 -
-
5IFK
1
?
A:
[8-306]
-
E
Q
R
A
L
I
K
S
A
H
R
Y
I
S
E
K
L
E
D
H
FS
S
E
F
L
P
K
A
L
V
I
C
G
S
G
L
S
G
I
S
T
K
I
A
DEP
K
P
-
L
I
L
S
Y
S
T
I
P
G
F
K
V
-------
G
E
L
I
F
G
Y
M
N
G
A
P
V
V
L
M
N
G
R
L
H
S
Y
E
G
H
S
L
A
E
T
V
H
P
I
R
A
L
H
L
L
G
S
I
N
V
L
I
V
T
N
A
A
G
G
I
--
N
AS
F
K
A
G
D
L
M
C
V
Y
D
H
I
N
F
---
P
---
G
---
L
C
GF
H
P
L
R
G
A
N
F
D
E
F
G
P
R
F
L
A
T
S
D
A
Y
D
L
E
L
R
K
L
L
F
S
K
K
K
E
L
--
N
I
ER
K
--
I
H
E
G
T
Y
S
Y
V
H
G
P
T
F
E
S
R
A
E
S
R
F
L
R
L
A
G
T
D
A
V
G
M
S
T
V
P
E
V
V
T
A
R
H
C
G
W
R
V
L
A
L
S
L
I
T
N
---
E
C
V
V
D
P
PASAHDENPVPIQE
G
K
A
---
T
H
E
E
V
L
E
N
S
A
K
A
S
K
D
V
Q
E
L
I
F
S
V
V
A
E
I
138
HHSearch
62.96
40%
-34
- C4 -
-
1G2O
2
PUNA_MYCTU
A:
[8-268]
--
P
D
E
L
A
R
R
A
A
Q
V
I
A
D
R
T
G-----
I
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
---
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
-
Q
I
M
V
L
T
N
A
A
G
G
L
--
R
AD
L
Q
V
G
Q
P
V
L
I
S
D
H
L
N
L
---
T
---
A
---
R
---
S
P
L
V
G
-------
G
E
F
V
D
L
T
D
A
Y
S
P
R
L
R
E
L
A
R
Q
S
D
------
P
--
Q
--
L
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
E
I
R
M
L
Q
T
L
G
A
D
L
V
G
M
S
T
V
H
E
T
I
A
A
R
A
A
G
A
E
V
L
G
V
S
L
V
T
N
---
L
A
A
G
I
T
G-------------
E
P
L
---
S
H
A
E
V
L
A
A
G
A
A
S
A
T
R
M
G
A
L
L
A
D
V
I
A
R
F
137
HHSearch
62.57
40%
-37
- C4 -
-
1I80
2
PUNA_MYCTU
A:
[8-268]
--
P
D
E
L
A
R
R
A
A
Q
V
I
A
D
R
T
G-----
I
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
---
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
-
Q
I
M
V
L
T
N
A
A
G
G
L
--
R
AD
L
Q
V
G
Q
P
V
L
I
S
D
H
L
N
L
---
T
---
A
---
R
---
S
P
L
V
G
-------
G
E
F
V
D
L
T
D
A
Y
S
P
R
L
R
E
L
A
R
Q
S
D
------
P
--
Q
--
L
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
E
I
R
M
L
Q
T
L
G
A
D
L
V
G
M
S
T
V
H
E
T
I
A
A
R
A
A
G
A
E
V
L
G
V
S
L
V
T
N
---
L
A
A
G
I
T
G-------------
E
P
L
---
S
H
A
E
V
L
A
A
G
A
A
S
A
T
R
M
G
A
L
L
A
D
V
I
A
R
F