@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0741: (2017-12-28 )
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVEAFAHQVWTSINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70.....----..----.80........90........100.......110.......120.......130.......140.......150.......160-.-.-.....170.......180.......190.......200-----.-----.-----.....210.......220.......230.......240.......250.......260.......270.......280.......290.......300....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTNE
F
L
H
F
E
K
I
S
R
Q
T
W
Q
S
L
HRKTTPPL
T
E
E
E
L
E
S
I
K
S
FNDQIS
L
Q
D
V
T
D
I
Y
L
P
L
A
H
L
I
Q
I
Y
K
R
T
K
E
D
LAFSK
G
I
F
L
----
Q
R----ESKSQ
P
F
I
I
GVSG
S
V
AVGK
S
T
T
S
R
L
L
Q
I
L
L
S
RTFTD
A
T
V
E
L
V
TTDGFLYP
N
Q
T
L
I
E
QGILNRKGFPESY
D
M
E
A
L
L
N
F
L
D
R
IKNG-Q-D-VD
I
P
VYSHE
V
Y
DIVPEEKQSVKAA
D
F
V
I
V
EG
I
N
V
FQNP-----Q-----N-----
D
R
L
Y
I
T
D
FF
D
F
S
I
Y
V
DAG
V
D
D
I
E
S
W
Y
L
D
R
F
L
K
M
L
S
L
AQNDPD
S
Y
Y
Y
R
F
TQMP
I
G
E
V
E
A
F
A
H
Q
V
W
TSI
N
L
T
N
L
Q
N
Y
I
E
PTRNR
A
E
V
I
L
HKSKNHE
I
D
E
I
YLKK
84
HHSearch
84.51
46%
-40
- C3 -
-
3TQC
1
COAA_COXBU
B:
[13-319]
----
I
T
P
Y
L
Q
F
N
R
Q
Q
W
G
N
F
----
P
L
T
L
T
E
S
D
L
D
K
L
Q
G
Q
I
E
I
V
S
L
K
E
V
T
E
I
Y
L
P
L
S
R
L
L
S
F
Y
V
T
A
R
Q
T
L
Q
Q
A
T
Y
Q
F
L
----
G
K
----
P
E
P
K
V
P
Y
I
I
G
I
A
G
S
V
A
V
G
K
S
T
T
S
R
V
L
K
A
L
L
S
R
W
P
D
H
P
N
V
E
V
I
T
T
D
G
F
L
Y
S
N
A
K
L
E
K
Q
G
L
M
K
R
K
G
F
P
E
S
Y
D
M
P
S
L
L
R
V
L
N
A
I
K
S
G
-
Q
R
N
-
V
R
I
P
V
Y
S
H
H
Y
Y
D
I
V
R
G
Q
Y
E
I
V
D
Q
P
D
I
V
I
L
E
G
L
N
I
L
Q
T
G
-----
V
-----
R
KTLQ
Q
L
Q
V
F
V
S
D
F
F
D
F
S
L
F
V
D
A
Q
A
Q
V
I
Q
K
W
Y
I
D
R
V
L
S
F
W
R
T
T
F
K
D
P
H
S
Y
F
H
Y
L
T
Q
M
S
E
T
E
V
A
A
F
A
K
H
V
W
N
E
I
N
K
V
N
L
M
E
N
I
L
P
Y
K
N
R
A
Q
L
I
L
E
K
A
A
D
H
S
I
Q
K
V
Y
L
R
-
3
PsiBlast_PDB
83.91
44%
-6
- C3 -
-
3AVQ
10
COAA_MYCTU
A:
[25-321]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
79
HHSearch
83.87
42%
-29
* C3 *
-
4NE2
2
COAA_KLEP3
A:
[26-334]
---
L
M
T
P
Y
L
Q
F
N
R
H
Q
W
A
A
L
R
-----
T
L
T
E
D
E
I
T
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
H
V
E
L
I
T
T
D
G
F
L
H
P
N
S
V
L
K
E
R
G
L
M
K
K
K
G
F
P
Q
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
-
V
P
Q
-
A
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
A
Q
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
-----
D
YPHDP
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
E
L
L
K
S
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
S
K
E
E
A
V
D
I
A
T
S
L
W
N
E
I
N
L
M
N
L
K
E
N
I
L
P
T
R
E
R
A
S
L
I
M
T
K
S
A
N
H
S
V
N
Q
V
R
L
R
K
21
PsiBlast_CBE
83.61
45%
-35
- C3 -
-
3TQC
1
COAA_COXBU
B:
[13-320]
----
I
T
P
Y
L
Q
F
N
R
Q
Q
W
G
N
F
----
P
L
T
L
T
E
S
D
L
D
K
L
Q
G
Q
I
E
I
V
S
L
K
E
V
T
E
I
Y
L
P
L
S
R
L
L
S
F
Y
V
T
A
R
Q
T
L
Q
Q
A
T
Y
Q
F
L
----
G
K
----
P
E
P
K
V
P
Y
I
I
G
I
A
G
S
V
A
V
G
K
S
T
T
S
R
V
L
K
A
L
L
S
R
W
P
D
H
P
N
V
E
V
I
T
T
D
G
F
L
Y
S
N
A
K
L
E
K
Q
G
L
M
K
R
K
G
F
P
E
S
Y
D
M
P
S
L
L
R
V
L
N
A
I
K
S
G
-
Q
R
N
-
V
R
I
P
V
Y
S
H
H
Y
Y
D
I
V
R
G
Q
Y
E
I
V
D
Q
P
D
I
V
I
L
E
G
L
N
I
L
Q
T
G
V
RKTL
Q
-----
Q
-----
L
Q
V
F
V
S
D
F
F
D
F
S
L
F
V
D
A
Q
A
Q
V
I
Q
K
W
Y
I
D
R
V
L
S
F
W
R
T
T
F
K
D
P
H
S
Y
F
H
Y
L
T
Q
M
S
E
T
E
V
A
A
F
A
K
H
V
W
N
E
I
N
K
V
N
L
M
E
N
I
L
P
Y
K
N
R
A
Q
L
I
L
E
K
A
A
D
H
S
I
Q
K
V
Y
L
R
K
1
PsiBlast_PDB
83.16
45%
-34
- C3 -
-
3TQC
1
COAA_COXBU
A:
[13-320]
----
I
T
P
Y
L
Q
F
N
R
Q
Q
W
G
N
------
L
T
L
T
E
S
D
L
D
K
L
Q
G
Q
I
E
I
V
S
L
K
E
V
T
E
I
Y
L
P
L
S
R
L
L
S
F
Y
V
T
A
R
Q
T
L
Q
Q
A
T
Y
Q
F
L
----
G
K
----
P
E
P
K
V
P
Y
I
I
G
I
A
G
S
V
A
V
G
K
S
T
T
S
R
V
L
K
A
L
L
S
R
W
P
D
H
P
N
V
E
V
I
T
T
D
G
F
L
Y
S
N
A
K
L
E
K
Q
G
L
M
K
R
K
G
F
P
E
S
Y
D
M
P
S
L
L
R
V
L
N
A
I
K
S
G
-
Q
R
N
-
V
R
I
P
V
Y
S
H
H
Y
Y
D
I
V
R
G
Q
Y
E
I
V
D
Q
P
D
I
V
I
L
E
G
L
N
I
L
Q
T
G
V
RKTL
Q
-----
Q
-----
L
Q
V
F
V
S
D
F
F
D
F
S
L
F
V
D
A
Q
A
Q
V
I
Q
K
W
Y
I
D
R
V
L
S
F
W
R
T
T
F
K
D
P
H
S
Y
F
H
Y
L
T
Q
M
S
E
T
E
V
A
A
F
A
K
H
V
W
N
E
I
N
K
V
N
L
M
E
N
I
L
P
Y
K
N
R
A
Q
L
I
L
E
K
A
A
D
H
S
I
Q
K
V
Y
L
R
K
83
HHSearch
83.12
46%
-39
- C3 -
-
3TQC
1
COAA_COXBU
A:
[13-319]
----
I
T
P
Y
L
Q
F
N
R
Q
Q
W
G
N
------
L
T
L
T
E
S
D
L
D
K
L
Q
G
Q
I
E
I
V
S
L
K
E
V
T
E
I
Y
L
P
L
S
R
L
L
S
F
Y
V
T
A
R
Q
T
L
Q
Q
A
T
Y
Q
F
L
----
G
K
----
P
E
P
K
V
P
Y
I
I
G
I
A
G
S
V
A
V
G
K
S
T
T
S
R
V
L
K
A
L
L
S
R
W
P
D
H
P
N
V
E
V
I
T
T
D
G
F
L
Y
S
N
A
K
L
E
K
Q
G
L
M
K
R
K
G
F
P
E
S
Y
D
M
P
S
L
L
R
V
L
N
A
I
K
S
G
-
Q
R
N
-
V
R
I
P
V
Y
S
H
H
Y
Y
D
I
V
R
G
Q
Y
E
I
V
D
Q
P
D
I
V
I
L
E
G
L
N
I
L
Q
T
G
-----
V
-----
R
KTLQQ
L
Q
V
F
V
S
D
F
F
D
F
S
L
F
V
D
A
Q
A
Q
V
I
Q
K
W
Y
I
D
R
V
L
S
F
W
R
T
T
F
K
D
P
H
S
Y
F
H
Y
L
T
Q
M
S
E
T
E
V
A
A
F
A
K
H
V
W
N
E
I
N
K
V
N
L
M
E
N
I
L
P
Y
K
N
R
A
Q
L
I
L
E
K
A
A
D
H
S
I
Q
K
V
Y
L
R
-
80
HHSearch
83.04
43%
-35
- C3 -
-
1SQ5
2
COAA_ECOLI
D:
[1-308]
----
M
T
P
Y
L
Q
F
D
R
N
Q
W
A
A
L
R
D
---
M
T
L
S
E
D
E
I
A
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
R
V
E
L
I
T
T
D
G
F
L
H
P
N
Q
V
L
K
E
R
G
L
M
K
K
K
G
F
P
E
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
-
V
P
N
-
V
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
V
-
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
DYPHD
P
-----
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
D
L
L
Q
T
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
T
K
E
E
A
I
K
T
A
M
T
L
W
K
E
I
N
W
L
N
L
K
Q
N
I
L
P
T
R
E
R
A
S
L
I
L
T
K
S
A
N
H
A
V
E
E
V
R
L
R
K
16
PsiBlast_PDB
82.92
44%
-4
- C3 -
-
3AEZ
15
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
5
PsiBlast_PDB
82.91
44%
-4
- C3 -
-
2GET
3
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
10
PsiBlast_PDB
82.83
44%
-4
- C3 -
-
2ZS9
10
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
39
PsiBlast_CBE
82.80
42%
-35
- C3 -
-
1SQ5
2
COAA_ECOLI
D:
[4-308]
----
Y
L
Q
F
D
---
R
N
Q
W
A
A
L
R
D
---
M
T
L
S
E
D
E
I
A
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
R
V
E
L
I
T
T
D
G
F
L
H
P
N
Q
V
L
K
E
R
G
L
M
K
K
K
G
F
P
E
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
V
P
-
N
-
V
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
V
-
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
-----
D
YPHDP
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
D
L
L
Q
T
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
T
K
E
E
A
I
K
T
A
M
T
L
W
K
E
I
N
W
L
N
L
K
Q
N
I
L
P
T
R
E
R
A
S
L
I
L
T
K
S
A
N
H
A
V
E
E
V
R
L
R
K
14
PsiBlast_PDB
82.68
44%
-2
- C3 -
-
2ZSE
13
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
48
PsiBlast_CBE
82.66
41%
-28
- C3 -
-
4GI7
2
COAA_KLEP3
C:
[32-334]
---------
Q
F
N
R
H
Q
W
A
A
L
R
D
S
V
P
M
T
L
T
E
D
E
I
T
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
H
V
E
L
I
T
T
D
G
F
L
H
P
N
S
V
L
K
E
R
G
L
M
K
K
K
G
F
P
Q
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
V
P
-
Q
-
A
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
A
Q
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
-----
D
YPHDP
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
E
L
L
K
S
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
S
K
E
E
A
V
D
I
A
T
S
L
W
N
E
I
N
L
M
N
L
K
E
N
I
L
P
T
R
E
R
A
S
L
I
M
T
K
S
A
N
H
S
V
N
Q
V
R
L
R
K
8
PsiBlast_PDB
82.44
44%
-2
- C3 -
-
2ZS7
11
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
G
E
P
Q
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
42
PsiBlast_CBE
82.39
41%
-29
- C3 -
-
4NE2
2
COAA_KLEP3
A:
[32-334]
---------
Q
F
N
R
H
Q
W
A
A
L
R
-----
T
L
T
E
D
E
I
T
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
H
V
E
L
I
T
T
D
G
F
L
H
P
N
S
V
L
K
E
R
G
L
M
K
K
K
G
F
P
Q
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
V
P
-
Q
-
A
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
A
Q
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
-----
D
YPHDP
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
E
L
L
K
S
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
S
K
E
E
A
V
D
I
A
T
S
L
W
N
E
I
N
L
M
N
L
K
E
N
I
L
P
T
R
E
R
A
S
L
I
M
T
K
S
A
N
H
S
V
N
Q
V
R
L
R
K
15
PsiBlast_PDB
82.37
44%
-5
- C3 -
-
2ZSF
7
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
20
PsiBlast_PDB
82.31
44%
-1
- C3 -
-
3AF3
11
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
19
PsiBlast_PDB
82.21
44%
-0
- C3 -
-
3AF2
12
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
36
PsiBlast_CBE
82.20
44%
-16
- C3 -
-
4BFS
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEP---------
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
11
PsiBlast_PDB
82.20
44%
-1
- C3 -
-
2ZSA
13
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
81
HHSearch
82.19
44%
-7
- C3 -
-
2GES
1
COAA_MYCTU
A:
[5-311]
--
S
E
P
S
P
Y
V
E
F
D
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
----
G
E
PQQN
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
D
Y
-
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
G
-----
P
------------
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
9
PsiBlast_PDB
82.18
44%
-6
- C3 -
-
2ZS8
6
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
32
PsiBlast_CBE
82.09
44%
-0
- C3 -
-
4BFU
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
24
PsiBlast_CBE
82.04
44%
3
- C3 -
-
4BFY
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
2
PsiBlast_PDB
82.04
44%
-7
- C3 -
-
3AVO
9
COAA_MYCTU
A:
[25-321]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
37
PsiBlast_CBE
81.91
44%
-6
- C3 -
-
3AVP
12
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
4
PsiBlast_PDB
81.81
44%
-3
- C3 -
-
2GES
1
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
18
PsiBlast_PDB
81.71
44%
-4
- C3 -
-
3AF1
13
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
38
PsiBlast_CBE
81.66
44%
-3
- C3 -
-
3AF4
14
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
12
PsiBlast_PDB
81.50
44%
-3
- C3 -
-
2ZSB
7
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
22
PsiBlast_CBE
81.46
44%
4
- C3 -
-
4BFZ
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
13
PsiBlast_PDB
81.38
44%
-5
- C3 -
-
2ZSD
12
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
6
PsiBlast_PDB
81.35
44%
-13
- C3 -
-
2GEU
1
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEP-------
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
28
PsiBlast_CBE
81.27
44%
-1
- C3 -
-
4BFW
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
7
PsiBlast_PDB
81.17
44%
-2
- C3 -
-
2GEV
8
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
27
PsiBlast_CBE
81.16
44%
-0
- C3 -
-
4BFX
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
25
PsiBlast_CBE
81.10
44%
-3
- C3 -
-
4BFY
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
17
PsiBlast_PDB
81.10
44%
-6
- C3 -
-
3AF0
10
COAA_MYCTU
A:
[15-311]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
29
PsiBlast_CBE
81.03
44%
-1
- C3 -
-
4BFW
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
30
PsiBlast_CBE
80.97
44%
0
- C3 -
-
4BFV
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
33
PsiBlast_CBE
80.66
44%
3
- C3 -
-
4BFU
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
34
PsiBlast_CBE
80.63
44%
4
- C3 -
-
4BFT
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
31
PsiBlast_CBE
80.63
44%
2
- C3 -
-
4BFV
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
26
PsiBlast_CBE
80.56
44%
4
- C3 -
-
4BFX
1
COAA_MYCTU
B:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
82
HHSearch
80.46
44%
-3
- C3 -
-
4BFZ
1
COAA_MYCTU
A:
[14-317]
-----
S
P
Y
V
E
F
D
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
----
G
E
PQQN
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
D
Y
-
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
G
-----
P
------------
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
40
PsiBlast_CBE
80.30
42%
-33
- C3 -
-
1SQ5
2
COAA_ECOLI
B:
[4-308]
----
Y
L
Q
F
D
---
R
N
Q
W
A
A
L
R
------
L
S
E
D
E
I
A
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
R
V
E
L
I
T
T
D
G
F
L
H
P
N
Q
V
L
K
E
R
G
L
M
K
K
K
G
F
P
E
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
V
P
-
N
-
V
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
V
Q
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
-----
D
YPHDP
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
D
L
L
Q
T
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
T
K
E
E
A
I
K
T
A
M
T
L
W
K
E
I
N
W
L
N
L
K
Q
N
I
L
P
T
R
E
R
A
S
L
I
L
T
K
S
A
N
H
A
V
E
E
V
R
L
R
K
23
PsiBlast_CBE
80.03
44%
1
- C3 -
-
4BFZ
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
35
PsiBlast_CBE
79.06
44%
-0
- C3 -
-
4BFT
1
COAA_MYCTU
A:
[21-317]
------------
R
R
Q
W
R
A
L
R
M
S
T
P
L
A
L
T
E
E
E
L
V
G
L
R
G
L
G
E
Q
I
D
L
L
E
V
E
E
V
Y
L
P
L
A
R
L
I
H
L
Q
V
A
A
R
Q
R
L
F
A
A
T
A
E
F
L
GEPQ
Q
N
----
P
D
R
P
V
P
F
I
I
G
V
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
A
R
W
D
H
H
P
R
V
D
L
V
T
T
D
G
F
L
Y
P
N
A
E
L
Q
R
R
N
L
M
H
R
K
G
F
P
E
S
Y
N
R
R
A
L
M
R
F
V
T
S
V
K
S
G
-
S
-
D
Y
A
C
A
P
V
Y
S
H
L
H
Y
D
I
I
P
G
A
E
Q
V
V
R
H
P
D
I
L
I
L
E
G
L
N
V
L
Q
T
------------
G
-----
P
T
L
M
V
S
D
L
F
D
F
S
L
Y
V
D
A
R
I
E
D
I
E
Q
W
Y
V
S
R
F
L
A
M
R
T
T
A
F
A
D
P
E
S
H
F
H
H
Y
A
A
F
S
D
S
Q
A
V
V
A
A
R
E
I
W
R
T
I
N
R
P
N
L
V
E
N
I
L
P
T
R
P
R
A
T
L
V
L
R
K
D
A
D
H
S
I
N
R
L
R
L
R
K
41
PsiBlast_CBE
78.20
41%
-25
- C3 -
-
4NE2
2
COAA_KLEP3
B:
[32-334]
---------
Q
F
N
R
H
Q
W
A
A
L
R
-------
T
E
D
E
I
T
R
L
K
G
I
N
E
D
L
S
L
E
E
V
A
E
I
Y
L
P
L
S
R
L
L
N
F
Y
I
S
S
N
L
R
R
Q
A
V
L
E
Q
F
L
----
G
T
----
N
G
Q
R
I
P
Y
I
I
S
I
A
G
S
V
A
V
G
K
S
T
T
A
R
V
L
Q
A
L
L
S
R
W
P
E
H
R
H
V
E
L
I
T
T
D
G
F
L
H
P
N
S
V
L
K
E
R
G
L
M
K
K
K
G
F
P
Q
S
Y
D
M
H
R
L
V
K
F
V
S
D
L
K
S
G
V
P
-
Q
-
A
T
A
P
V
Y
S
H
L
I
Y
D
V
I
P
D
G
D
K
T
V
A
Q
P
D
I
L
I
L
E
G
L
N
V
L
Q
S
G
-----
M
-----
D
YPHDP
H
H
V
F
V
S
D
F
V
D
F
S
I
Y
V
D
A
P
E
E
L
L
K
S
W
Y
I
N
R
F
L
K
F
R
E
G
A
F
T
D
P
D
S
Y
F
H
N
Y
A
K
L
S
K
E
E
A
V
D
I
A
T
S
L
W
N
E
I
N
L
M
N
L
K
E
N
I
L
P
T
R
E
R
A
S
L
I
M
T
K
S
A
N
H
S
V
N
Q
V
R
L
R
K