@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0744: (2017-12-28 )
MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVNKHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKADKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70.-.-.--.--....80........-90........100.......110.......120.......130.......140.......150-.....--..160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....----...270.......280-----......----.----290.----..-..----..300.......310...---..-----.-.--320.--------..-.....---.330--..---------.......340.......350.......360.......370.......380.......390.....-..400.......410.......--420...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
A
V
D
L
I
Q
KKRDGQEL
T
S
S
E
I
E
W
L
V
E
G
Y
VSGTVP
D
Y
Q
M
S
A
F
A
M
A
V
Y
FKGMTT
R
E
I
S
D
L
T
M
N
M
V
KTGQEFDLS-A-I--D--
G
V
K
VNKHSTGGVG
D
-
K
V
T
L
I
L
V
P
L
V
A
SFGVP
V
A
KMSGRGLGHTGG
T
I
D
K
L
E
SIKG
Y
Q
VER
S
Q
E
D
F
I
R
Q
V
Q
D
I
G
V
S
V
IG-QSD
Q
L
--
V
K
A
D
K
L
L
Y
A
L
R
D
V
T
ATV
D
T
I
P
L
I
A
S
S
V
M
S
K
K
IAAGA
D
A
I
L
L
D
V
TVGE
G
A
F
M
K
T
V
D
E
A
R
E
L
A
Q
T
M
V
D
L
G
K
V
VGR
K
T
V
A
V
ITD
M
S
Q
P
L
G
R
A
I
G
N
R
L
E
I
L
E
A
L
E
I
L
-QGQGR
Q
----
D
I
T
H
F
I
C
E
L
A
Q
I
M
L
G
L-----AN
V
N
K
T
----
V
----
E
E
V
R
----
Q
H
-
L
E----N
G
Q
A
L
A
K
F
E
E
M
V
Q
AQGG
D
---
L
E
-----
D
-
L
--Y--R--------PV-N
V
A
H
V
---
V
E----IP---------AQETG
V
I
S
A
L
P
A
M
D
F
G
L
Y
A
M
RLGAGRAVKSDALDYET
G
I
V
F
E
K
KIGDSVQK
G
E
I
V
A
K
V
YTNEKI
P
-
P
Q
L
V
T
D
F
Q
K
C
V
K
I
S
D
E
V
K
K
I
R
E
--
I
V
E
IIS
21
PsiBlast_CBE
96.08
59%
-61
- C5 -
-
1BRW
1
PDP_GEOSE
A:
[1-400]
M
R
M
V
D
L
I
A
K
K
R
D
G
K
A
L
T
K
E
E
I
E
W
I
V
R
G
Y
T
N
G
D
I
P
D
Y
Q
M
S
A
L
A
M
A
I
Y
F
R
G
M
T
E
E
E
T
A
A
L
T
M
A
M
V
Q
S
G
E
M
L
D
L
S
-
S
-
I
--
R
--
G
V
K
V
D
K
H
S
T
G
G
V
G
D
-
T
T
T
L
V
L
G
P
L
V
A
S
V
G
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
S
V
P
G
F
H
V
E
I
S
K
D
E
F
I
R
L
V
N
E
N
G
I
A
I
I
G
-
Q
T
G
D
L
--
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
A
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
K
L
D
E
A
R
R
L
A
R
V
M
V
D
I
G
K
R
V
G
R
R
T
M
A
V
I
S
D
M
S
Q
P
L
G
Y
A
V
G
N
A
L
E
V
K
E
A
I
E
T
L
-
K
G
N
G
P
H
----
D
L
T
E
L
C
L
T
L
G
S
H
M
V
Y
L
-----
A
E
K
A
P
S
----
L
----
D
E
A
R
----
R
L
-
L
E
E
A
I
R
S
G
A
A
I
A
A
F
K
T
F
L
A
A
Q
G
G
D
ASV
V
D
-----
D
-
L
--
D
--
K
--------
L
P
-
K
A
A
Y
T
---
S
T
----
V
T
---------
A
A
A
D
G
Y
V
A
E
M
A
A
D
D
I
G
T
A
A
M
W
L
G
A
G
R
A
K
K
E
D
V
I
D
L
A
V
G
I
V
L
H
K
K
I
G
D
R
V
Q
K
G
E
A
L
A
T
I
H
S
N
-----------------------------------
36
HHSearch
95.44
55%
-47
- C5 -
-
1BRW
1
PDP_GEOSE
A:
[1-433]
M
R
M
V
D
L
I
A
K
K
R
D
G
K
A
L
T
K
E
E
I
E
W
I
V
R
G
Y
T
N
G
D
I
P
D
Y
Q
M
S
A
L
A
M
A
I
Y
F
R
G
M
T
E
E
E
T
A
A
L
T
M
A
M
V
Q
S
G
E
M
L
D
L
S
-
S
-
I
--
R
--
G
V
K
V
D
K
H
S
T
G
G
V
G
D
-
T
T
T
L
V
L
G
P
L
V
A
S
V
G
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
S
V
P
G
F
H
V
E
I
S
K
D
E
F
I
R
L
V
N
E
N
G
I
A
I
I
G
-
Q
T
G
D
L
--
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
A
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
K
L
D
E
A
R
R
L
A
R
V
M
V
D
I
G
K
R
V
G
R
R
T
M
A
V
I
S
D
M
S
Q
P
L
G
Y
A
V
G
N
A
L
E
V
K
E
A
I
E
T
L
-
K
G
N
G
P
H
----
D
L
T
E
L
C
L
T
L
G
S
H
M
V
Y
L
-----
A
E
K
A
P
S
----
L
D
E
A
R
R
L
L
E
----
E
A
-
I
R
----
S
G
A
A
I
A
A
F
K
T
F
L
A
A
Q
G
G
D
---
A
S
-----
V
V
D
--
D
L-
D
--------
K
L
P
K
A
A
Y
T
---
S
T
----
V
T
---------
A
A
A
D
G
Y
V
A
E
M
A
A
D
D
I
G
T
A
A
M
W
L
G
A
G
R
A
K
K
E
D
V
I
D
L
A
V
G
I
V
L
H
K
K
I
G
D
R
V
Q
K
G
E
A
L
A
T
I
H
S
N
R
P
D
V
-
L
D
V
K
E
K
I
E
A
A
I
R
L
S
P
Q
P
V
A
R
P
P
L-
I
Y
E
T
I
V
1
PsiBlast_PDB
93.33
59%
-60
- C5 -
-
1BRW
2
PDP_GEOSE
B:
[1-400]
M
R
M
V
D
L
I
A
K
K
R
D
G
K
A
L
T
K
E
E
I
E
W
I
V
R
G
Y
T
N
G
D
I
P
D
Y
Q
M
S
A
L
A
M
A
I
Y
F
R
G
M
T
E
E
E
T
A
A
L
T
M
A
M
V
Q
S
G
E
M
L
D
L
S
-
S
-
I
--
R
--
G
V
K
V
D
K
H
S
T
G
G
V
G
D
-
T
T
T
L
V
L
G
P
L
V
A
S
V
G
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
S
V
P
G
F
H
V
E
I
S
K
D
E
F
I
R
L
V
N
E
N
G
I
A
I
I
G
-
Q
T
G
D
L
--
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
A
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
K
L
D
E
A
R
R
L
A
R
V
M
V
D
I
G
K
R
V
G
R
R
T
M
A
V
I
S
D
M
S
Q
P
L
G
Y
A
V
G
N
A
L
E
V
K
E
A
I
E
T
L
-
K
G
N
G
P
H
----
D
L
T
E
L
C
L
T
L
G
S
H
M
V
Y
L
-----
A
E
K
A
P
S
----
L
----
D
E
A
R
----
R
L
-
L
E
EAIR
S
G
A
A
I
A
A
F
K
T
F
L
A
A
Q
G
G
D
ASV
V
D
-----
D
-
L
--
D
--
K
--------
L
P
-
K
A
A
Y
T
---
S
T
----
V
T
---------
A
A
A
D
G
Y
V
A
E
M
A
A
D
D
I
G
T
A
A
M
W
L
G
A
G
R
A
K
K
E
D
V
I
D
L
A
V
G
I
V
L
H
K
K
I
G
D
R
V
Q
K
G
E
A
L
A
T
I
H
S
N
-----------------------------------
3
PsiBlast_PDB
90.24
48%
-43
- C5 -
-
3H5Q
1
PDP_STAAC
A:
[5-435]
-
R
M
I
D
I
I
E
K
K
R
D
G
H
T
L
T
T
E
E
I
N
F
F
I
G
G
Y
V
K
G
D
I
P
D
Y
Q
A
S
S
L
A
M
A
I
Y
F
Q
D
M
N
D
D
E
R
V
A
L
T
M
A
M
V
N
S
G
D
M
I
D
L
S
-
D
-
I
--
K
--
G
V
K
V
D
K
H
S
T
G
G
V
G
D
-
T
T
T
L
V
L
A
P
L
V
A
A
V
D
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
A
I
D
G
F
H
V
E
I
D
E
A
T
F
V
K
L
V
N
E
N
K
V
A
V
V
G
-
Q
S
G
N
L
--
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
G
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
S
G
A
F
M
K
T
L
E
D
A
E
A
L
A
H
A
M
V
R
I
G
N
N
V
G
R
N
T
M
A
I
I
S
D
M
N
Q
P
L
G
R
A
I
G
N
A
L
E
L
Q
E
A
I
D
T
L
-
K
G
Q
G
P
K
----
D
L
T
E
L
V
L
T
L
G
S
Q
M
V
V
L
-----
A
N
K
A
E
T
----
L
----
E
E
A
R
A
L
L
I
E
A
-
I
N
----
S
G
A
A
L
E
K
F
K
T
F
I
K
N
Q
G
G
D
---
E
T
-----
V
-
I
--
D
--
H
--------
P
E
-
R
L
P
Q
A
Q
Y
Q
I
E
----
Y
K
---------
A
K
K
S
G
Y
V
T
E
L
V
S
N
D
I
G
V
A
S
M
M
L
G
A
G
R
L
T
K
E
D
D
I
D
L
A
V
G
I
V
L
N
K
K
I
G
D
K
V
E
E
G
E
S
L
L
T
I
H
S
N
R
Q
D
V
-
D
D
V
V
K
K
L
D
S
S
I
T
I
A
D
H
V
V
S
P
T
L
--
I
H
K
I
I
T
2
PsiBlast_PDB
88.73
53%
-37
- C5 -
-
5EP8
-
PDP_BACSU
A:
[1-432]
M
R
M
V
D
I
I
I
K
K
Q
N
G
K
E
L
T
T
E
E
I
Q
F
F
V
N
G
Y
T
D
G
S
I
P
D
Y
Q
A
S
A
L
A
M
A
I
F
F
R
D
M
S
D
R
E
R
A
D
L
T
M
A
M
V
N
S
G
E
T
I
D
L
S
-
A
-
I
--
E
--
G
I
K
V
D
K
H
S
T
G
G
V
G
D
-
T
T
T
L
V
L
A
P
L
V
A
A
L
D
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
A
I
D
G
F
H
V
E
L
T
K
R
E
F
I
K
L
V
N
R
D
K
V
A
V
I
G
-
Q
S
G
N
L
--
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
G
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
A
G
A
F
M
K
T
E
E
D
A
A
E
L
A
K
A
M
V
R
I
G
N
N
V
G
R
Q
T
M
A
V
I
S
D
M
S
Q
P
L
G
F
A
I
G
N
A
L
E
V
K
E
A
I
D
T
L
-
K
G
E
G
P
E
----
D
L
H
E
L
V
L
T
L
G
S
Q
M
V
V
L
-----
A
K
K
A
D
T
----
L
----
D
E
A
R
----
A
K
-
L
E
E
V
M
K
N
G
K
A
L
E
K
F
K
D
F
L
K
N
Q
G
G
D
S
S
I
V
D
-----
D
-
P
--
S
--
K
--------
L
P
-
Q
A
A
Y
Q
---
I
D
----
V
P
---------
A
K
E
A
G
V
V
S
E
I
V
A
D
E
I
G
V
A
A
M
L
L
G
A
G
R
A
T
K
E
D
E
I
D
L
A
V
G
I
M
L
R
K
K
V
G
D
K
V
E
K
G
E
P
L
V
T
L
Y
A
N
R
E
N
V
-
D
E
V
I
A
K
V
Y
D
N
I
R
I
A
A
E
A
K
A
P
K
L
--
I
H
T
L
I
T
38
HHSearch
86.78
43%
-37
- C5 -
-
2DSJ
-
?
B:
[1-423]
M
N
P
V
A
F
I
R
E
K
R
E
G
K
K
H
R
R
E
D
L
E
A
F
L
L
G
Y
L
R
D
E
V
P
D
Y
Q
V
S
A
W
L
M
A
A
F
L
R
G
L
D
P
E
E
T
L
W
L
T
E
T
M
A
R
S
G
K
V
L
D
L
S
-
G
----
L
--
P
H
P
V
D
K
H
S
S
G
G
V
G
D
-
K
V
S
L
V
V
G
P
I
L
A
A
S
G
C
T
F
A
K
M
S
G
R
G
L
A
H
T
G
G
T
I
D
K
L
E
S
V
P
G
W
R
G
E
M
T
E
A
E
F
L
E
R
A
R
R
V
G
L
V
I
A
A
-
Q
S
P
D
L
--
A
P
L
D
G
K
L
Y
A
L
R
D
V
T
A
T
V
E
S
V
P
L
I
A
S
S
I
M
S
K
K
L
A
A
G
A
R
S
I
V
L
D
V
K
V
G
R
G
A
F
M
K
T
L
E
E
A
R
L
L
A
K
T
M
V
A
I
G
Q
G
A
G
R
R
V
R
A
L
L
T
S
M
E
A
P
L
G
R
A
V
G
N
A
I
E
V
R
E
A
I
E
A
L
-
K
G
E
G
P
G
----
D
L
L
E
V
A
L
A
L
A
E
E
A
L
R
L
-----
E
G
L
D
P
----------
A
L
A
R
----
K
A
-
L
E
----
G
G
A
A
L
E
K
F
R
A
F
L
E
A
Q
G
G
D
---
P
R
-----
A
V
E
--
D
--
F
--------
S
L
L
P
L
A
E
E
---
H
P
----
L
R
---------
A
E
R
E
G
V
V
R
E
V
D
A
Y
K
V
G
L
A
V
L
A
L
G
G
G
R
K
R
K
G
E
P
I
D
H
G
V
G
V
Y
L
L
K
K
P
G
D
R
V
E
R
G
E
A
L
A
L
V
Y
H
R
R
R
G
L
-
E
E
A
L
G
H
L
R
E
A
Y
A
L
G
E
E
A
-
H
P
A
P
L-
V
L
E
A
I
-
4
PsiBlast_PDB
86.65
42%
-40
- C5 -
-
2DSJ
-
?
A:
[1-423]
M
N
P
V
A
F
I
R
E
K
R
E
G
K
K
H
R
R
E
D
L
E
A
F
L
L
G
Y
L
R
D
E
V
P
D
Y
Q
V
S
A
W
L
M
A
A
F
L
R
G
L
D
P
E
E
T
L
W
L
T
E
T
M
A
R
S
G
K
V
L
D
L
S
-
G
-
L
--
P
--
H
-
P
V
D
K
H
S
S
G
G
V
G
D
-
K
V
S
L
V
V
G
P
I
L
A
A
S
G
C
T
F
A
K
M
S
G
R
G
L
A
H
T
G
G
T
I
D
K
L
E
S
V
P
G
W
R
G
E
M
T
E
A
E
F
L
E
R
A
R
R
V
G
L
V
I
A
A
-
Q
S
P
D
L
--
A
P
L
D
G
K
L
Y
A
L
R
D
V
T
A
T
V
E
S
V
P
L
I
A
S
S
I
M
S
K
K
L
A
A
G
A
R
S
I
V
L
D
V
K
V
G
R
G
A
F
M
K
T
L
E
E
A
R
L
L
A
K
T
M
V
A
I
G
Q
G
A
G
R
R
V
R
A
L
L
T
S
M
E
A
P
L
G
R
A
V
G
N
A
I
E
V
R
E
A
I
E
A
L
-
K
G
E
G
P
G
----
D
L
L
E
V
A
L
A
L
A
E
E
A
L
R
L
-----
E
G
L
D
P
A
----
L
------
A
R
----
K
A
-
L
E
----
G
G
A
A
L
E
K
F
R
A
F
L
E
A
Q
G
G
D
PRA
V
E
-----
D
----
F
--
S
--------
L
L
-
P
L
A
E
E
---
H
P
----
L
R
---------
A
E
R
E
G
V
V
R
E
V
D
A
Y
K
V
G
L
A
V
L
A
L
G
G
G
R
K
R
K
G
E
P
I
D
H
G
V
G
V
Y
L
L
K
K
P
G
D
R
V
E
R
G
E
A
L
A
L
V
Y
H
R
R
R
G
L
-
E
E
A
L
G
H
L
R
E
A
Y
A
L
G
E
E
A
H
P
A
P
L
--
V
L
E
A
I
-
37
HHSearch
81.43
51%
-1
- C5 -
-
3H5Q
1
PDP_STAAC
A:
[4-435]
M
R
M
I
D
I
I
E
K
K
R
D
G
H
T
L
T
T
E
E
I
N
F
F
I
G
G
Y
V
K
G
D
I
P
D
Y
Q
A
S
S
L
A
M
A
I
Y
F
Q
D
M
N
D
D
E
R
V
A
L
T
M
A
M
V
N
S
G
D
M
I
D
L
S
-
D
-
I
--
K
--
G
V
K
V
D
K
H
S
T
G
G
V
G
D
-
T
T
T
L
V
L
A
P
L
V
A
A
V
D
V
P
V
A
K
M
S
G
R
G
L
G
H
T
G
G
T
I
D
K
L
E
A
I
D
G
F
H
V
E
I
D
E
A
T
F
V
K
L
V
N
E
N
K
V
A
V
V
G
Q
S
-
G
N
L
--
T
P
A
D
K
K
L
Y
A
L
R
D
V
T
G
T
V
N
S
I
P
L
I
A
S
S
I
M
S
K
K
I
A
A
G
A
D
A
I
V
L
D
V
K
T
G
S
G
A
F
M
K
T
L
E
D
A
E
A
L
A
H
A
M
V
R
I
G
N
N
V
G
R
N
T
M
A
I
I
S
D
M
N
Q
P
L
G
R
A
I
G
N
A
L
E
L
Q
E
A
I
D
T
L
-
K
G
Q
G
P
K
----
D
L
T
E
L
V
L
T
L
G
S
Q
M
V
V
L
-----
A
N
K
A
E
T
----
L
E
E
A
R
A
L
L
I
----
E
A
-
I
N
----
S
G
A
A
L
E
K
F
K
T
F
I
K
N
Q
G
G
D
---
E
T
-----
V
I
D
--
H
--
P
E-------
R
L
P
Q
A
Q
Y
Q
---
I
E
----
Y
K
---------
A
K
K
S
G
Y
V
T
E
L
V
S
N
D
I
G
V
A
S
M
M
L
G
A
G
R
L
T
K
E
D
D
I
D
L
A
V
G
I
V
L
N
K
K
I
G
D
K
V
E
E
G
E
S
L
L
T
I
H
S
N
R
Q
D
V
-
D
D
V
V
K
K
L
D
S
S
I
T
I
A
D
H
-
V
V
S
P
T
L-
I
H
K
I
I
T
32
PsiBlast_CBE
78.27
38%
-64
- C5 -
-
2WK5
1
TYPH_HUMAN
B:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
---
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
Q
A
Q
G
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
R
R
Q
L
L
P
RAR
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
39
HHSearch
74.96
37%
-17
- C5 -
-
1UOU
1
TYPH_HUMAN
A:
[28-469]
K
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
-
E
A
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
--
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
----
Q
A
Q
G
A
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
---
P
G
-----
L
A
R
A
L
C
--
S
GS
P
A
E
R
R
Q
L
L
P
R
A
R
E
Q
---
E
E
----
L
L
---------
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
--------
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
G
P
A
L
S
G
P
Q
S
R
A
L
Q
E
A
L
V
L
S
D
R
A
P
F
A
A
P
L
P
F
A
E
L
V
-
35
HHSearch
72.42
37%
-12
- C5 -
-
2WK5
-
TYPH_HUMAN
A:
[34-477]
K
Q
L
P
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
-
E
A
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
----
Q
A
Q
G
A
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
---
P
G
-----
L
A
R
A
L
C
--
S
GS
P
A
E
R
R
Q
L
L
P
R
A
R
E
Q
---
E
E
----
L
L
---------
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
G
P
A
L
S
G
P
Q
S
R
A
L
Q
E
A
L
V
L
S
D
R
A
P
F
A
A
P
SP
F
A
E
L
V
-
20
PsiBlast_PDB
70.99
38%
-21
- C5 -
-
1UOU
1
TYPH_HUMAN
A:
[32-435]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
--
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
Q
A
Q
G
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
R
R
Q
L
L
P
RAR
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
--------
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
17
PsiBlast_PDB
70.46
38%
-13
- C5 -
-
2J0F
1
TYPH_HUMAN
A:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
A
G
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
Q
A
Q
G
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
R
R
Q
L
L
P
RAR
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
19
PsiBlast_PDB
69.36
38%
-11
- C5 -
-
2WK6
1
TYPH_HUMAN
A:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
Q
A
Q
G
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
R
R
Q
L
L
P
RAR
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
31
PsiBlast_CBE
69.28
38%
-11
- C5 -
-
2WK6
1
TYPH_HUMAN
B:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
QAQG
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
RRQL
L
P
RAREQEELL
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
30
PsiBlast_CBE
69.14
38%
-13
- C5 -
-
2J0F
1
TYPH_HUMAN
B:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
A
G
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
QAQG
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
RRQL
L
P
RAREQEELL
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
29
PsiBlast_CBE
69.05
38%
-13
- C5 -
-
2J0F
1
TYPH_HUMAN
C:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
A
G
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
QAQG
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
RRQL
L
P
RAREQEELL
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
41
HHSearch
68.38
30%
-20
* C5 *
-
4GA5
-
AMPPA_THEKO
A:
[86-492]
-
E
S
V
R
Y
I
K
K
K
M
H
G
E
K
L
R
K
V
E
I
E
A
I
V
R
D
I
V
D
R
K
L
R
D
I
E
I
S
S
F
V
T
A
L
E
I
N
G
L
D
M
D
E
I
A
A
L
T
I
A
M
A
E
T
G
D
M
L
D
I
D
-
R
-------
K
P
I
M
D
V
H
S
I
G
G
V
P
G
N
K
T
N
I
L
V
V
P
I
V
A
A
A
G
L
T
I
P
K
T
S
S
R
A
I
T
S
A
A
G
T
A
D
V
V
E
V
F
-
A
-
D
V
S
F
S
L
D
E
I
K
R
I
V
E
K
V
G
A
C
L
V
W
-
G
-
G
A
L
NL
A
P
A
D
D
I
T
I
K
A
E
R
A
L
-
S
I
D
P
T
G
L
M
L
A
S
I
M
S
K
K
Y
A
M
G
S
Q
Y
V
L
I
D
I
P
T
G
K
G
V
K
V
E
T
V
E
E
A
R
S
L
A
R
D
F
I
E
L
G
K
R
L
G
Q
Y
V
E
V
A
I
T
Y
G
G
Q
P
I
G
H
T
V
G
P
A
L
E
A
R
E
A
L
S
A
L
M
T
G
K
G
P
G
----
S
L
I
E
K
A
T
G
L
A
G
I
L
L
E
M
-----
G
G
V
A
-
P
----
A
GT
G
K
K
M
A
K
----
E
I
-
L
E
----
S
G
K
A
W
E
K
M
K
E
I
I
E
A
Q
G
G
D
---
P
N
-----
I
K
P
--
E
-----------
E
I
P
I
G
D
K
T
---
Y
T
----
F
T
---------
A
A
T
S
G
Y
V
T
A
I
D
N
R
A
I
T
A
I
A
R
A
A
G
A
P
E
D
-------
K
G
A
G
I
E
L
Y
V
K
V
G
E
K
V
K
E
G
D
P
L
F
T
I
H
A
E
H
E
A
R
L
D
Q
A
I
V
L
A
R
R
T
E
P
I
R
I
---------------
18
PsiBlast_PDB
68.28
38%
-11
- C5 -
-
2WK5
-
TYPH_HUMAN
A:
[38-443]
----
E
L
I
R
M
K
R
D
G
G
R
L
S
E
A
D
I
R
G
F
V
A
A
V
V
N
G
S
A
Q
G
A
Q
I
G
A
M
L
M
A
I
R
L
R
G
M
D
L
E
E
T
S
V
L
T
Q
A
L
A
Q
S
G
Q
Q
L
E
W
P
E
A
-
W
--
R
--
Q
Q
L
V
D
K
H
S
T
G
G
V
G
D
-
K
V
S
L
V
L
A
P
A
L
A
A
C
G
C
K
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
N
V
I
Q
S
P
E
Q
M
Q
V
L
L
D
Q
A
G
C
C
I
V
G
-
Q
S
E
Q
L
--
V
P
A
D
G
I
L
Y
A
A
R
D
V
T
A
T
V
D
S
L
P
L
I
T
A
S
I
L
S
K
K
L
V
E
G
L
S
A
L
V
V
D
V
K
F
G
G
A
A
V
F
P
N
Q
E
Q
A
R
E
L
A
K
T
L
V
G
V
G
A
S
L
G
L
R
V
A
A
A
L
T
A
M
D
K
P
L
G
R
C
V
G
H
A
L
E
V
E
E
A
L
L
C
M
-
D
G
A
G
P
P
----
D
L
R
D
L
V
T
T
L
G
G
A
L
L
W
L
-----
S
G
H
A
G
T
Q
A
Q
G
A
----
A
R
V
A
----
A
A
-
L
D
----
D
G
S
A
L
G
R
F
E
R
M
L
A
A
Q
G
V
D
----
P
-----
G
-
L
--
A
--
R
--------
A
L
-
C
S
G
S
P
---
A
E
R
R
Q
L
L
P
RAR
E
Q
E
E
L
L
A
P
A
D
G
T
V
E
L
V
R
A
L
P
L
A
L
V
L
H
E
L
G
A
G
R
S
R
A
G
E
P
L
R
L
G
V
G
A
E
L
L
V
D
V
G
Q
R
L
R
R
G
T
P
W
L
R
V
H
R
D
-----------------------------------
16
PsiBlast_PDB
66.95
38%
3
- C5 -
-
4LHM
3
TYPH_ECOLI
A:
[4-407]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
HL
N
--
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
P
R
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
TDF
V
E
-----
N
-
Y
--
A
--
K
--------
Y
L
-
P
T
A
M
L
---
T
K
A
---
V
Y
---------
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
---------------------------------
14
PsiBlast_PDB
66.59
38%
4
- C5 -
-
4EAD
5
TYPH_ECOLI
A:
[4-407]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
HL
N
--
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
P
R
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
TDF
V
E
-----
N
-
Y
--
A
--
K
--------
Y
L
-
P
T
A
M
L
---
T
K
A
---
V
Y
---------
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
---------------------------------
24
PsiBlast_CBE
65.96
39%
4
- C5 -
-
4YYY
3
TYPH_SALTY
B:
[4-411]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
--
N
LN
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
A
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
Q
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
G
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
PRLF
D
V
T
M
A
L
C
V
E
M
L
I
S
G
Q
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
---
S
D
FVENY
D
-
K
--
Y
--
L
--------
P
T
-
A
M
L
S
K
---
A
-----
V
Y
---------
A
D
T
E
G
F
I
S
A
M
D
T
R
A
L
G
M
A
V
V
S
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
S
I
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
A
S
-
W
Q
----------------------------
7
PsiBlast_PDB
65.70
39%
2
- C5 -
-
4YEK
6
TYPH_SALTY
A:
[4-411]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
--
N
LN
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
A
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
Q
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
G
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
P
R
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
Q
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
---
S
D
FVENY
D
-
K
--
Y
--
L
--------
P
T
-
A
M
L
S
K
---
A
-----
V
Y
---------
A
D
T
E
G
F
I
S
A
M
D
T
R
A
L
G
M
A
V
V
S
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
S
I
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
A
S
-
W
Q
----------------------------
8
PsiBlast_PDB
65.60
39%
0
- C5 -
-
4YYY
3
TYPH_SALTY
A:
[4-411]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
--
N
LN
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
A
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
Q
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
G
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
P
R
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
Q
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
---
S
D
FVENY
D
-
K
--
Y
--
L
--------
P
T
-
A
M
L
S
K
---
A
-----
V
Y
---------
A
D
T
E
G
F
I
S
A
M
D
T
R
A
L
G
M
A
V
V
S
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
S
I
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
A
S
-
W
Q
----------------------------
25
PsiBlast_CBE
63.81
39%
5
- C5 -
-
4YEK
4
TYPH_SALTY
B:
[4-411]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
--
N
LN
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
A
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
Q
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
G
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
PRLF
D
V
T
M
A
L
C
V
E
M
L
I
S
G
Q
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
---
S
D
FVENY
D
-
K
--
Y
--
L
--------
P
T
-
A
M
L
S
K
---
A
-----
V
Y
---------
A
D
T
E
G
F
I
S
A
M
D
T
R
A
L
G
M
A
V
V
S
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
S
I
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
A
S
-
W
Q
----------------------------
5
PsiBlast_PDB
63.48
39%
7
- C5 -
-
4X46
3
TYPH_SALTY
A:
[4-411]
--
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
--
N
LN
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
V
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
A
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
Q
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
G
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
N
P
R
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
Q
L
-----
A
K
D
D
A
E
----
A
----
R
A
K
L
----
Q
A
V
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
---
S
D
FVENY
D
-
K
--
Y
--
L
--------
P
T
-
A
M
L
S
K
---
A
-----
V
Y
---------
A
D
T
E
G
F
I
S
A
M
D
T
R
A
L
G
M
A
V
V
S
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
S
I
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
A
S
-
W
Q
----------------------------
40
HHSearch
62.78
36%
15
- C5 -
-
4EAD
5
TYPH_ECOLI
A:
[2-439]
F
L
A
Q
E
I
I
R
K
K
R
D
G
H
A
L
S
D
E
E
I
R
F
F
I
N
G
I
R
D
N
T
I
S
E
G
Q
I
A
A
L
A
M
T
I
F
F
H
D
M
T
M
P
E
R
V
S
L
T
M
A
M
R
D
S
G
T
V
L
D
W
K
-
S
-
L
HL
N
--
G
P
I
V
D
K
H
S
T
G
G
V
G
D
-
V
T
S
L
M
L
G
P
M
V
A
A
C
G
G
Y
I
P
M
I
S
G
R
G
L
G
H
T
G
G
T
L
D
K
L
E
S
I
P
G
F
D
I
F
P
D
D
N
R
F
R
E
I
I
K
D
V
G
V
A
I
I
G
-
Q
T
S
S
L
--
A
P
A
D
K
R
F
Y
A
T
R
D
I
T
A
T
V
D
S
I
P
L
I
T
A
S
I
L
A
K
K
L
A
E
G
L
D
A
L
V
M
D
V
K
V
G
S
G
A
F
M
P
T
Y
E
L
S
E
A
L
A
E
A
I
V
G
V
A
N
G
A
G
V
R
T
T
A
L
L
T
D
M
N
Q
V
L
A
S
S
A
G
N
A
V
E
V
R
E
A
V
Q
F
L
-
T
G
E
Y
R
--------
N
P
R
L
F
D
V
T
M
A
L
C
V
E
M
L
I
S
G
K
L
A
K
D
----
D
A
E
A
R
A
K
L
Q
----
A
V
-
L
D
----
N
G
K
A
A
E
V
F
G
R
M
V
A
A
Q
K
G
P
---
T
D
-----
F
V
E
--
N
YA
K
--------
Y
L
P
T
A
M
L
T
---
K
A
----
V
Y
---------
A
D
T
E
G
F
V
S
E
M
D
T
R
A
L
G
M
A
V
V
A
M
G
G
G
R
R
Q
A
S
D
T
I
D
Y
S
V
G
F
T
D
M
A
R
L
G
D
Q
V
D
G
Q
R
P
L
A
V
I
H
A
K
D
E
N
N
W
Q
E
A
A
K
A
V
K
A
A
I
K
L
A
D
K
A
P
E
S
T
P
T-
V
Y
R
R
I
S