@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0918: (2018-01-01 )
MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQDITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQNPDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGAGMGAILETQRELREVLNDGVKPCDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAFPGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTAELKFELK
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110......--.120-.........130.......140.......150.......160.......170.......180.....-...190........--------200.......210...--..--..220.......230.......240.......250.......260.......270.......280.......290.......300.......310...--......320.......330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
G
Y
T
V
A
V
VGAT
G
A
V
G
A
Q
M
I
K
M
L
E
E
STL
P
I
D
K
I
R
Y
L
A
S
A
R
SAGKSLKFKDQ
D
I
T
I
EETTETAFEG
V
D
I
A
L
F
SAGSSTSAKYA
P
Y
A
V
K
A
G
V
V
V
VDN
T
S
Y
FRQNPDV
P
L
V
V
PEVN
A
H
A
LDA--HN---
G
I
I
ACPNC
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
KWGL
D
R
I
I
V
S
T
Y
Q
A
VSGAG
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
NDGV-KPC
D
L
H
-
A
E
ILP-SGGDK
K
H
Y
--------
P
I
A
FNALP
Q
I
D
V
FTDN--DY--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
MEDD
S
I
A
V
S
A
T
C
V
R
I
P
V
LSAHS
E
S
V
Y
I
E
TKEVA
P
I
E
E
V
K
A
A
I
A
AFPG
A
V
LE
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
AVGSR
D
T
F
V
G
R
I
R
K
D
--LDA--EK
G
I
H
M
W
V
VSDNLLKGAAWN
S
V
Q
I
A
E
T
L
H
ERGLVRP
T
A
E
L
K
F
ELK
24
PsiBlast_CBE
97.93
100%
-92
- C3 -
-
4R4J
7
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
22
PsiBlast_CBE
97.68
100%
-95
- C3 -
-
4R54
2
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
35
PsiBlast_CBE
97.57
100%
-98
- C3 -
-
3PYL
1
?
B:
[2-355]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
---
5
PsiBlast_PDB
97.56
100%
-95
- C3 -
-
3PWK
7
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
21
PsiBlast_CBE
97.47
100%
-93
- C3 -
-
4R5H
6
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
12
PsiBlast_PDB
97.45
100%
-95
- C3 -
-
4R3N
4
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
37
PsiBlast_CBE
97.37
100%
-95
- C3 -
-
3PWK
7
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
31
PsiBlast_CBE
97.35
100%
-91
- C3 -
-
3Q11
5
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
8
PsiBlast_PDB
97.31
100%
-92
- C3 -
-
3PYX
5
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
16
PsiBlast_PDB
97.28
100%
-97
- C3 -
-
4R51
9
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
14
PsiBlast_PDB
97.24
100%
-93
- C3 -
-
4R41
8
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
29
PsiBlast_CBE
97.09
100%
-96
- C3 -
-
3Q1L
1
?
C:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
15
PsiBlast_PDB
96.99
100%
-90
- C3 -
-
4R4J
5
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
13
PsiBlast_PDB
96.93
100%
-94
- C3 -
-
4R3W
6
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
3
PsiBlast_PDB
96.85
100%
-95
- C3 -
-
2GZ2
1
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
34
PsiBlast_CBE
96.81
100%
-95
- C3 -
-
3PYL
1
?
C:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
23
PsiBlast_CBE
96.78
100%
-99
- C3 -
-
4R51
7
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
6
PsiBlast_PDB
96.71
100%
-95
- C3 -
-
3PWS
2
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
32
PsiBlast_CBE
96.70
100%
-93
- C3 -
-
3PZB
5
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
17
PsiBlast_PDB
96.53
100%
-94
- C3 -
-
4R54
2
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
9
PsiBlast_PDB
96.50
100%
-92
- C3 -
-
3PZB
5
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
10
PsiBlast_PDB
96.46
100%
-93
- C3 -
-
3Q11
5
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
18
PsiBlast_PDB
96.40
100%
-93
- C3 -
-
4R5H
7
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
36
PsiBlast_CBE
96.19
100%
-94
- C3 -
-
3PWS
2
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
33
PsiBlast_CBE
96.14
100%
-90
- C3 -
-
3PYX
6
?
B:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
27
PsiBlast_CBE
96.06
100%
-100
- C3 -
-
4R3N
7
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
26
PsiBlast_CBE
96.05
100%
-96
- C3 -
-
4R3W
6
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
25
PsiBlast_CBE
95.30
100%
-96
- C3 -
-
4R41
7
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
-
K
P
C
D
L
H
-
A
E
I
L
P
-
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
50
HHSearch
89.90
98%
-47
- C3 -
-
4R3N
4
?
A:
[2-358]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
R
S
A
G
K
S
L
K
F
K
D
Q
D
I
T
I
E
E
T
T
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
A
H
A
L
D
A
--
H
N
---
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
A
--
E
I
L
P
S
G
G
-
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
A
H
Q
I
Y
P
Q
A
I
N
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
43
PsiBlast_CBE
66.48
39%
-36
- C3 -
-
3TZ6
4
DHAS_MYCTU
A:
[1-340]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
R
S
Q
G
R
K
L
A
F
R
G
Q
E
I
E
V
E
D
A
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
R
-
D
A
--
H
R
RPK
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
---------
G
-
A
E
Q
L
V
-
Y
D
G
G
A
L
E
F
PPPNTYVA
P
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
--
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
------
V
P
T
P
L
A
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
PG
V
P
D
--
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
-----------------
64
HHSearch
66.06
40%
-28
- C3 -
-
3TZ6
4
DHAS_MYCTU
A:
[1-342]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
R
S
Q
G
R
K
L
A
F
R
G
Q
E
I
E
V
E
D
A
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
R
D
A
H
RR
P
K
---
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
G
A
E
-
Q
L
V
Y
D
G
G
A
L
E
F
P
-
P
P
-
N
T
Y
V
A
--------
P
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
GS
G
E
--
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
------
V
P
T
P
L
A
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
--
P
G
V
PD
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
---------------
44
PsiBlast_CBE
65.19
39%
-34
- C3 -
-
3VOS
3
DHAS_MYCTU
A:
[19-358]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
R
----
K
L
A
F
R
G
Q
E
I
E
V
E
D
A
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
R
-
D
A
--
H
R
RPK
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
---------
G
-
A
E
Q
L
V
-
Y
D
G
G
A
L
E
F
PPPNTYVA
P
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
--
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
------
V
P
T
P
L
A
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
PG
V
P
D
--
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
-----------------