@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0928: (2018-01-01 )
MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVMAAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQANCAAYMSLIEPGDTVMGMDLAAGGHLTHGAPVSFSGQTYNFLSYSVDPETELLDFDAILKQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPVPYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFKEVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQNLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKNSENEAVLEEVRSAVKELTDAFPLYED
Atome Classification :
(72 SA)
--------.........10........20........30........40........50........60........70........80......----..----90---.----........100.......110.......120.......130---..-----.-----......140.....--..150.......160.......170.......180.......190.......200.......210.......220.......230.......240----------.-----------.-----..---.------..-----------.-------250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380....---------..----------------.------------390----------------------...---..------------------------...400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MIFDKDD
F
K
A
Y
D
A
D
L
W
N
A
I
A
K
E
E
E
R
QQN
N
I
E
L
I
ASE
N
V
V
S
K
A
V
M
A
AQG
S
I
L
T
N
KYAEGYPGRRYYGG
T
D
V
V
D
V
V
E
T
L
A
I
E
R
A
K
E
I
FG----AK----F----A----NVQPHSGSQ
A
N
C
A
A
Y
M
S
LIEPGD
T
V
M
G
M
D
LAAGGHLTHG-----AP-----V-----SFSG
Q
T
Y
N
F
L
S
Y
SV--DPETELL
D
F
D
A
I
L
K
Q
A
Q
EVKP
K
L
I
V
A
G
A
S
A
Y
S
Q
I
I
D
F
S
K
F
R
E
I
A
D
A
V
G
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
AGLHPSPV
P
Y
A
H
I
T
TTTTHKTLRGPRG
G
L
I
L
-----------T-----------
N
-----
D
E
---
E
------
L
A
-----------
K
-------
K
I
N
S
A
IFPGIQGG
P
L
E
H
V
V
A
A
K
A
V
S
F
K
E
V
L
D
P
A
F
K
E
Y
A
A
N
V
I
KNSK
A
M
A
D
V
F
LQDP
D
F
R
I
ISGGTE
N
H
L
F
L
V
D
V
T
K
V
VEN
G
K
V
A
Q
N
L
L
D
E
V
N
I
T
LNKNSIPYETLSPFKTS
G
I
R
I
G
A
A
A
I
T
ARGFG
E
E
E
S
R
K
V
A
E
L
I
---------
I
K
----------------
T
------------LK-----------------------NSE---
N
E
------------------------
A
V
L
E
E
V
R
S
A
V
K
E
L
T
D
AFPLYED
1
PsiBlast_PDB
96.19
81%
-75
- C1 -
-
4WXG
3
GLYA_STRT1
A:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
21
PsiBlast_CBE
95.69
81%
-76
- C1 -
-
4WXG
2
GLYA_STRT1
C:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
22
PsiBlast_CBE
95.66
81%
-75
- C1 -
-
4WXF
2
GLYA_STRT1
C:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
3
PsiBlast_PDB
95.10
81%
-76
- C1 -
-
4WXB
3
GLYA_STRT1
A:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
23
PsiBlast_CBE
95.02
81%
-77
- C1 -
-
4WXB
3
GLYA_STRT1
D:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
2
PsiBlast_PDB
94.82
81%
-76
- C1 -
-
4WXF
4
GLYA_STRT1
A:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
25
PsiBlast_CBE
94.16
81%
-84
- C1 -
-
4WXB
3
GLYA_STRT1
B:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
---------------
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
24
PsiBlast_CBE
93.67
81%
-81
- C1 -
-
4WXB
3
GLYA_STRT1
C:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
---------------
P
-----
V
-----
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
--
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
16
PsiBlast_PDB
87.52
63%
-85
- C1 -
-
2VGT
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
41
PsiBlast_CBE
87.23
63%
-84
- C1 -
-
2VMT
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
9
PsiBlast_PDB
87.07
63%
-86
- C1 -
-
2VI8
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
15
PsiBlast_PDB
86.81
63%
-84
- C1 -
-
2VGS
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
20
PsiBlast_PDB
86.76
63%
-87
- C1 -
-
2W7D
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
47
PsiBlast_CBE
86.73
63%
-84
- C1 -
-
2VMX
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
49
PsiBlast_CBE
86.66
63%
-84
- C1 -
-
2VMV
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
31
PsiBlast_CBE
86.66
63%
-84
- C1 -
-
2VMQ
5
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
19
PsiBlast_PDB
86.65
63%
-84
- C1 -
-
2VGU
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
32
PsiBlast_CBE
86.56
63%
-85
- C1 -
-
2VMP
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
4
PsiBlast_PDB
86.51
64%
-83
- C1 -
-
1KKJ
1
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
45
PsiBlast_CBE
86.47
63%
-83
- C1 -
-
2VMY
7
?
B:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
46
PsiBlast_CBE
86.27
63%
-85
- C1 -
-
2VMY
7
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
28
PsiBlast_CBE
86.26
63%
-83
- C1 -
-
2W7G
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
43
PsiBlast_CBE
86.15
63%
-85
- C1 -
-
2VMR
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
40
PsiBlast_CBE
86.06
63%
-84
- C1 -
-
2VMU
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
29
PsiBlast_CBE
86.02
63%
-82
- C1 -
-
2W7F
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
27
PsiBlast_CBE
85.99
63%
-85
- C1 -
-
2W7H
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
44
PsiBlast_CBE
85.96
63%
-85
- C1 -
-
2VMZ
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
33
PsiBlast_CBE
85.95
63%
-84
- C1 -
-
2VMO
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
10
PsiBlast_PDB
85.92
63%
-84
- C1 -
-
2VIB
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
5
PsiBlast_PDB
85.90
64%
-81
- C1 -
-
1KKP
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
48
PsiBlast_CBE
85.89
63%
-82
- C1 -
-
2VMW
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
34
PsiBlast_CBE
85.89
63%
-83
- C1 -
-
2VMN
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
38
PsiBlast_CBE
85.88
63%
-83
- C1 -
-
2W7J
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
12
PsiBlast_PDB
85.87
63%
-83
- C1 -
-
2VI9
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
35
PsiBlast_CBE
85.82
63%
-84
- C1 -
-
2W7M
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
26
PsiBlast_CBE
85.76
64%
-82
- C1 -
-
1KL2
6
?
B:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
6
PsiBlast_PDB
85.65
64%
-84
- C1 -
-
1KL1
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
30
PsiBlast_CBE
85.62
63%
-83
- C1 -
-
2W7E
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
42
PsiBlast_CBE
85.60
63%
-85
- C1 -
-
2VMS
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
14
PsiBlast_PDB
85.60
63%
-86
- C1 -
-
1YJZ
1
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
17
PsiBlast_PDB
85.52
63%
-84
- C1 -
-
2VGV
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
18
PsiBlast_PDB
85.45
63%
-82
- C1 -
-
2VGW
3
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
8
PsiBlast_PDB
85.40
63%
-84
- C1 -
-
1YJS
1
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
Q
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
13
PsiBlast_PDB
85.37
63%
-86
- C1 -
-
1YJY
1
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
121
HHSearch
85.35
61%
-77
- C1 -
-
2DKJ
2
GLYA_THET8
B:
[6-407]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
----
A
A
----
W
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-----
V
-----
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
--
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
S
-----------
N
-----
D
P
---
E
------
L
G
-----------
K
-------
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
A
R
-
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
I
---------
D
R
----------------
A
------------
L
L
-----------------------
E
G
P
---
S
----------------------------
E
A
L
R
E
E
V
R
R
L
A
L
A
H
P
M
P
--
11
PsiBlast_PDB
85.29
63%
-82
- C1 -
-
2VIA
4
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
36
PsiBlast_CBE
85.24
63%
-85
- C1 -
-
2W7L
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
7
PsiBlast_PDB
85.23
64%
-81
- C1 -
-
1KL2
6
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
39
PsiBlast_CBE
84.91
63%
-83
- C1 -
-
2W7I
1
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
37
PsiBlast_CBE
84.75
63%
-83
- C1 -
-
2W7K
2
?
A:
[8-405]
-------------------
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
--
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
------
E
---
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
-
L
Q
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
51
PsiBlast_CBE
84.23
63%
-77
- C1 -
-
2DKJ
2
GLYA_THET8
A:
[8-398]
-------------------
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
----
A
A
----
W
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-----
V
-----
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
--
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
S
-----------
N
-----
D
P
---
E
------
L
G
-----------
K
-------
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
A
R
R
-
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
I
---------
D
R
----------------
A
------------
L
L
-----------------------
E
G
P
---
S
E
------------------------
A
L
R
E
E
V
R
---------------
50
PsiBlast_CBE
83.48
63%
-77
- C1 -
-
2DKJ
2
GLYA_THET8
B:
[8-398]
-------------------
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
----
A
A
----
W
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
-----
S
R
-----
V
-----
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
--
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
S
-----------
N
-----
D
P
---
E
------
L
G
-----------
K
-------
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
A
R
R
-
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
P
E
E
M
P
L
V
A
E
L
I
---------
D
R
----------------
A
------------
L
L
-----------------------
E
G
P
---
S
E
------------------------
A
L
R
E
E
V
R
---------------
103
HHSearch
78.67
80%
16
- C1 -
-
4WXG
2
GLYA_STRT1
C:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
----
A
K
----
F
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
-----
A
P
-----
V
-----
S
F
S
G
--
K
T
Y
N
F
V
S
Y
NV
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
L
-----------
T
-----------
D
-----
D
E
---
D
------
I
A
-----------
K
-------
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
E
A
E
S
R
Q
I
A
E
W
M
---------
V
E
----------------
A
------------
L
E
-----------------------
N
H
D
---
K
P
------------------------
E
V
L
E
R
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
--
62
PsiBlast_CBE
73.53
58%
-18
- C1 -
-
3G8M
1
GLYA_ECOLI
A:
[11-416]
------------------
Y
D
A
E
L
W
Q
A
M
E
Q
E
K
V
R
Q
E
E
H
I
E
L
I
A
S
E
N
Y
T
S
P
R
V
M
Q
A
Q
G
S
Q
L
T
N
K
F
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
Q
L
A
I
D
R
A
K
E
L
F
G
----
A
D
----
Y
----
A
----
N
V
Q
P
H
S
G
S
Q
A
N
F
A
V
Y
T
A
L
L
E
P
G
D
T
V
L
G
M
N
L
A
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
K
L
Y
N
I
V
P
Y
G
I
--
D
-
A
T
G
H
I
D
Y
A
D
L
E
K
Q
A
K
E
H
K
P
K
M
I
I
G
G
F
S
A
Y
S
G
V
V
D
W
A
K
M
R
E
I
A
D
S
I
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
A
G
V
Y
P
N
P
V
P
H
A
H
V
V
T
T
T
T
H
K
T
L
A
G
P
R
G
G
L
I
L
-----------
A
K
G---------
G
-----
S
E
---
E
------
L
Y
-----------
K
-------
K
L
N
S
A
V
F
P
G
G
Q
G
G
P
L
M
H
V
I
A
G
K
A
V
A
L
K
E
A
M
E
P
E
F
K
T
Y
Q
Q
Q
V
A
K
N
A
K
A
M
V
E
V
F
L
E
R
-
G
Y
K
V
V
S
G
G
T
D
N
H
L
F
L
V
D
L
V
D
K
N
L
T
G
K
E
A
D
A
A
L
G
R
A
N
I
T
V
N
K
N
S
V
P
N
D
P
K
S
P
F
V
T
S
G
I
R
V
G
T
P
A
I
T
R
R
G
F
K
E
A
E
A
K
E
L
A
G
W
M
---------
C
D
----------------
V
------------
L
D
-----------------------
S
I
N
---
D
E
------------------------
A
V
I
E
R
I
K
G
K
V
L
D
I
C
A
R
Y
P
V
Y
--
117
HHSearch
71.39
62%
3
- C1 -
-
2VI8
3
?
A:
[3-405]
--------------
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
--
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
-----
E
----
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
-
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
120
HHSearch
70.52
62%
5
* C1 *
-
2VMN
3
?
A:
[5-405]
----------------
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
----
A
E
----
H
----
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
-----
S
P
-----
V
-----
N
F
S
G
--
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
L
-----------
C
-----------
Q
-----
E
----
Q
------
F
A
-----------
K
-------
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
Q
N
-
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
L
E
E
M
D
E
I
A
A
I
I
---------
G
L
----------------
V
------------
L
K
-----------------------
N
V
G
---
S
E
------------------------
Q
A
L
E
E
A
R
Q
R
V
A
A
L
T
D
-------
106
HHSearch
64.37
44%
-8
- C1 -
-
1RV3
2
GLYC_RABIT
B:
[21-479]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
----
L
D
----
P
QC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
-----
F
M
-----
T
DKKKI
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
-----------
Y
-----------
R
-----
R
G
----------
V
R
SVDK
E
I
L
Y
N
L
E
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------
L
T
V
---
Q
I
Q
D
D
T
GPRAT
L
K
E
F
K
E
K
L
A
GD
E
K
H
Q
R
A
V
R
A
L
R
Q
E
V
E
S
F
A
A
L
F
P
L
P
G
-
97
PsiBlast_CBE
62.82
40%
-19
- C1 -
-
1BJ4
1
GLYC_HUMAN
A:
[16-467]
---------------
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
V
--
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
K
G
VKSVDPA
T
-----------
G
-----
K
E
I
L
Y
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
-
L
T
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
R
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
G
I
E
L
T
L
Q
I
Q
S
D
T
GVAA
T
------------
L
K
E
F
K
E
R
L
A
----------------
G
D
K
---
Y
Q
------------------------
A
A
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
P
L
---
102
HHSearch
61.41
44%
6
- C1 -
-
4PVF
3
GLYM_HUMAN
A:
[27-479]
--------------
S
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
----
L
D
----
P
AQ
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
-----
Y
M
S
DVKR
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
--
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
-----------
Y
-----------
R
-----
K
G
---
V
KAIPY
T
F
E
-----------
D
-------
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
L
E
-
R
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
P
G
D
R
-
S
A
I
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
I
---------
D
E
----------------
G
------------
V
N
-----------------------
I
G
L
E
V
K
S
K
TA
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
T
S
------
Q
R
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
P
G
-
90
PsiBlast_CBE
61.00
43%
-12
- C1 -
-
1RVY
2
GLYC_RABIT
A:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------------------
E
ILY
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
92
PsiBlast_CBE
60.83
43%
-12
- C1 -
-
1RVU
2
GLYC_RABIT
A:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------------------
E
ILY
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
96
PsiBlast_CBE
60.14
43%
-13
- C1 -
-
1RV3
2
GLYC_RABIT
A:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------------------
E
ILY
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
89
PsiBlast_CBE
59.67
43%
-2
- C1 -
-
1RVY
2
GLYC_RABIT
B:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD--------------------
K
E
I
L
Y
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
91
PsiBlast_CBE
59.66
43%
-2
- C1 -
-
1RVU
2
GLYC_RABIT
B:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD--------------------
K
E
I
L
Y
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
126
Fugue
59.60
43%
6
- C1 -
-
1BJ4
1
GLYC_HUMAN
A:
[1-470]
DA
D
L
W
S
S
H
D
A
M
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
----
L
D
PQC
W
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
V
--
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
-----------
Y
R
K
G
VKSVDPAT
G
-----
K
E
---
I
L
Y
N---
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
T
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
R
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
L
T
L
Q
I
Q
S
D
T
GVAAT
L
K
E
F
K
E
R
L
A
G
D
K
---
Y
Q
------------------------
A
A
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
P
L
P
G
L
94
PsiBlast_CBE
59.54
43%
-13
- C1 -
-
1RV4
2
GLYC_RABIT
A:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------------------
E
ILY
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
83
PsiBlast_CBE
58.83
42%
-6
- C1 -
-
4PVF
3
GLYM_HUMAN
A:
[32-477]
-------------------
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
----
L
D
----
P
----
A
Q
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
Y
M
S
DV
K
R
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
--
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
-----------
Y
-----------
R
K
GVKA--------------------------IPY
T
F
E
D
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
L
E
R
-
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
P
G
D
R
-
S
A
I
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
I
D
E
G
V
N
I
G
L
E
V
K
----------------
S
K
TA
K
L
Q
D
F
K
S
F
L
L
K
-----------------------
D
S
E
---
T
S
------------------------
Q
R
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
---
82
PsiBlast_CBE
58.70
42%
-5
- C1 -
-
4PVF
2
GLYM_HUMAN
B:
[32-477]
-------------------
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
----
L
D
----
P
----
A
QWGV
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
YMSDV
K
R
-----
I
-----
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
--
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
F
-----------
Y
-----------
R
KGVKA--------------------------IPYTFED
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
L
E
R
-
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
--------
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
E
D
D
F
R
R
V
V
D
F
I
DEGVNIGLE
V
K
----------------
S
KTAKLQDFKSFL
L
K
-----------------------
D
S
E
---
T
S
------------------------
Q
R
L
A
N
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
---
95
PsiBlast_CBE
58.58
43%
-3
- C1 -
-
1RV3
2
GLYC_RABIT
B:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD--------------------
K
E
I
L
Y
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
85
PsiBlast_CBE
58.39
43%
-10
- C1 -
-
1CJ0
2
GLYC_RABIT
A:
[12-416]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD----------------------ILY
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
93
PsiBlast_CBE
57.36
43%
-3
- C1 -
-
1RV4
2
GLYC_RABIT
B:
[25-429]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD--------------------
K
E
I
L
Y
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------
84
PsiBlast_CBE
56.84
43%
-1
- C1 -
-
1CJ0
2
GLYC_RABIT
B:
[12-416]
---------------
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
LDPQ
C
W
----
G
----
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DK
K
K
-----
I
-----
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
--
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
V
RSVD--------------------
K
E
I
L
Y
N
------
L
E
-----------
S
-------
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
V
E
-
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
E
K
D
F
Q
K
V
A
H
F
I
---------
H
R
----------------
G
------------
I
E
-----------------------------------------------------------------------------